Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	UBA-like	UBQLN1 RNF31 UBAP2L CBL OTUD7B	6.16e-07	64	48	5	IPR009060
Domain	UBA	UBQLN1 RNF31 UBAP2L CBL	2.13e-06	36	48	4	PF00627
Domain	UBA	UBQLN1 RNF31 UBAP2L CBL	4.83e-06	44	48	4	IPR015940
Domain	UBA	UBQLN1 RNF31 UBAP2L CBL	6.31e-06	47	48	4	PS50030
Domain	UBA	UBQLN1 UBAP2L CBL	6.16e-05	30	48	3	SM00165
Domain	TIL	MUC19 TECTA	4.20e-04	12	48	2	PF01826
Domain	C8	MUC19 TECTA	4.20e-04	12	48	2	PF08742
Domain	PDZ	AHNAK DLG3 SCRIB ARHGEF11	4.68e-04	141	48	4	PF00595
Domain	Unchr_dom_Cys-rich	MUC19 TECTA	4.95e-04	13	48	2	IPR014853
Domain	C8	MUC19 TECTA	4.95e-04	13	48	2	SM00832
Domain	LBP_BPI_CETP	BPIFB4 BPIFA1	4.95e-04	13	48	2	PF01273
Domain	BPI/LBP/Plunc	BPIFB4 BPIFA1	4.95e-04	13	48	2	IPR032942
Domain	Bactericidal_perm-incr_a/b_dom	BPIFB4 BPIFA1	4.95e-04	13	48	2	IPR017943
Domain	Lipid-bd_serum_glycop_N	BPIFB4 BPIFA1	4.95e-04	13	48	2	IPR017942
Domain	PDZ	AHNAK DLG3 SCRIB ARHGEF11	5.62e-04	148	48	4	SM00228
Domain	TIL_dom	MUC19 TECTA	5.77e-04	14	48	2	IPR002919
Domain	-	AHNAK DLG3 SCRIB ARHGEF11	5.91e-04	150	48	4	2.30.42.10
Domain	PDZ	AHNAK DLG3 SCRIB ARHGEF11	6.06e-04	151	48	4	PS50106
Domain	PDZ	AHNAK DLG3 SCRIB ARHGEF11	6.21e-04	152	48	4	IPR001478
Domain	VWD	MUC19 TECTA	7.58e-04	16	48	2	SM00216
Domain	VWF_type-D	MUC19 TECTA	7.58e-04	16	48	2	IPR001846
Domain	VWFD	MUC19 TECTA	7.58e-04	16	48	2	PS51233
Domain	VWD	MUC19 TECTA	7.58e-04	16	48	2	PF00094
Domain	VWC_out	MUC19 TECTA	1.08e-03	19	48	2	SM00215
Domain	Tetraspanin	TSPAN10 ROM1	3.05e-03	32	48	2	IPR000301
Domain	Tetraspanin_EC2	TSPAN10 ROM1	3.05e-03	32	48	2	IPR008952
Domain	Tetraspannin	TSPAN10 ROM1	3.25e-03	33	48	2	PF00335
Domain	Tetraspanin/Peripherin	TSPAN10 ROM1	3.25e-03	33	48	2	IPR018499
Domain	VWC	MUC19 TECTA	4.29e-03	38	48	2	SM00214
Domain	VWFC_2	MUC19 TECTA	4.29e-03	38	48	2	PS50184
Domain	VWF_dom	MUC19 TECTA	5.22e-03	42	48	2	IPR001007
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	UBQLN1 AP5B1 NUP98 PEX5 MAML2 AJUBA OTUD7B SYNGAP1	1.48e-07	430	49	8	35044719
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	UBAP2L PEX5 DLG3 ZNF318 SCRIB CCDC6 ARHGEF11 CNOT1 KCNT1 SYNGAP1	7.80e-07	963	49	10	28671696
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	SALL2 NUP98 MUC19 ZNF318 CNOT1	8.58e-07	123	49	5	26912792
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNB KRT78 UBAP2L AHNAK NUP98 PEX5 ZNF318 SCRIB HEATR5B CNOT1	1.36e-06	1024	49	10	24711643
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FLNB UBAP2L AHNAK NUP98 ZNF318 SCRIB	1.61e-06	256	49	6	33397691
Pubmed	Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.	NTRK1 CBL	1.94e-06	2	49	2	21570973
Pubmed	SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.	DLG3 SYNGAP1	5.83e-06	3	49	2	9581761
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNB KRT78 UBAP2L AHNAK CNOT1	9.74e-06	202	49	5	33005030
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NEK1 UBAP2L AHNAK ZNF318 SCRIB CBL CNOT1	1.14e-05	549	49	7	38280479
Pubmed	The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation.	UBQLN1 CBL	1.16e-05	4	49	2	22451666
Pubmed	The roles of inflammation, STAT transcription factors, and nerve growth factor in viral reactivation and herpes keratitis.	NTRK1 STAT2	1.16e-05	4	49	2	12167251
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	GTPBP2 AHNAK NUP98 PEX5 DLG3 ZNF318 SCRIB OTUD7B	1.20e-05	777	49	8	35844135
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	NEK1 UBAP2L PEX5 CCDC6 HEATR5B AJUBA CBL CNOT1 STAT2	1.27e-05	1038	49	9	26673895
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	FLNB CDSN KRT78 UBAP2L AHNAK NUP98 SCRIB PEX11B CNOT1 MVK	1.73e-05	1367	49	10	32687490
Pubmed	Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.	NUP98 CBL	1.94e-05	5	49	2	18566322
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FLNB NEK1 SALL2 AHNAK ZNF318 CNOT1	2.63e-05	418	49	6	34709266
Pubmed	ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.	FLNB SCRIB ARHGEF11	2.90e-05	42	49	3	29107558
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG1 UBAP2L NUP98 ZNF318 SCRIB CCDC6	3.50e-05	440	49	6	34244565
Pubmed	MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma.	MEX3A CNOT1	4.07e-05	7	49	2	36112059
Pubmed	Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein.	NTRK1 CBL	4.07e-05	7	49	2	17548467
Pubmed	PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.	BPIFB4 BPIFA1	4.07e-05	7	49	2	11971875
Pubmed	Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.	FLNB SCRIB ARHGEF11	4.08e-05	47	49	3	32253237
Pubmed	Characterization of the piRNA complex from rat testes.	SCRIB CBL GBA2 OTUD7B	4.63e-05	140	49	4	16778019
Pubmed	Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers.	DLG3 SCRIB	5.42e-05	8	49	2	23397623
Pubmed	EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.	FLNB GTPBP2 KRT78	6.20e-05	54	49	3	35474131
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	FLNB UBAP2L AHNAK	6.20e-05	54	49	3	25631074
Pubmed	Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.	PEX5 PEX11B	6.96e-05	9	49	2	12096124
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FLNB AHNAK MUC19 LAMB3 SCRIB PTGER1 CNOT1	7.33e-05	736	49	7	29676528
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	FLNB UBAP2L NUP98 SCRIB CCDC6 CBL	7.33e-05	503	49	6	16964243
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	FLNB MEX3A UBAP2L NUP98 CNOT1	8.12e-05	315	49	5	26777405
Pubmed	mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.	MGMT CNOT1	8.69e-05	10	49	2	27618784
Pubmed	PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.	PEX5 PEX11B	8.69e-05	10	49	2	14709540
Pubmed	Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.	NEK1 CBL	8.69e-05	10	49	2	29891719
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MGMT UBAP2L NUP98 ZNF318 SCRIB CCDC6 OTUD7B	1.00e-04	774	49	7	15302935
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNB MEX3A AHNAK SCRIB CNOT1	1.04e-04	332	49	5	37433992
Pubmed	Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis.	PEX5 MVK	1.06e-04	11	49	2	11792727
Pubmed	Phylogenetic and evolutionary analysis of the PLUNC gene family.	BPIFB4 BPIFA1	1.06e-04	11	49	2	14739326
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	FLNB UBAP2L AHNAK NUP98 PEX11B GBA2	1.42e-04	568	49	6	37774976
Pubmed	Zellweger Spectrum Disorder	PEX5 PEX11B	1.50e-04	13	49	2	20301621
Pubmed	Agrin has a pathological role in the progression of oral cancer.	FLNB KRT78 RNF31 NUP98	1.73e-04	197	49	4	29872149
Pubmed	Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry.	RNF31 CBL	1.75e-04	14	49	2	28319114
Pubmed	Genome-wide association study in Han Chinese identifies three novel loci for human height.	MAML2 STAT2	1.75e-04	14	49	2	23456168
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	FLNB UBAP2L AHNAK CNOT1	1.94e-04	203	49	4	22083510
Pubmed	Comparative mapping of two adjacent regions of MMU19 with their human counterpart on HSA11q13.	AHNAK ROM1	2.02e-04	15	49	2	9730611
Pubmed	Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.	BPIFB4 BPIFA1	2.02e-04	15	49	2	21787333
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CDSN UBQLN1 RNF31 UBAP2L BPIFA1 AJUBA	2.06e-04	608	49	6	16713569
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	NEK1 PEX5 SCRIB CCDC6	2.17e-04	209	49	4	36779422
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	UBQLN1 UBAP2L AHNAK ZNF318 SCRIB	2.44e-04	399	49	5	35987950
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	KRT78 UBQLN1 DLG3 BPIFA1 PRDM6 SYNGAP1	2.49e-04	630	49	6	36949045
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	UBAP2L AHNAK NUP98 SCRIB CCDC6 ARHGEF11 AJUBA	2.81e-04	916	49	7	32203420
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 GTPBP2 RNF31 AP5B1 LAMB3 SCRIB	2.94e-04	650	49	6	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNB UBAP2L AHNAK NUP98 ZNF318 CNOT1	3.01e-04	653	49	6	22586326
Pubmed	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.	KLF1 STAT2	3.27e-04	19	49	2	34360789
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MEX3A RNF31 CBL	3.32e-04	95	49	3	29643511
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	NTRK1 CCDC6 STAT2	3.75e-04	99	49	3	19730683
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	UBQLN1 RNF31 UBAP2L	3.75e-04	99	49	3	31723608
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	UBAP2L AHNAK ZNF318 SCRIB	3.79e-04	242	49	4	34011540
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	CDSN SALL2 UBAP2L AHNAK ZNF318	3.98e-04	444	49	5	34795231
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	SALL2 TECTA	4.01e-04	21	49	2	32492250
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	SCRIB AJUBA	4.41e-04	22	49	2	27521426
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	SMG1 UBAP2L CNOT1	4.71e-04	107	49	3	30995489
Pubmed	p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.	LAMB3 AJUBA	5.26e-04	24	49	2	28604778
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT78 AHNAK CBL CNOT1	5.41e-04	266	49	4	19380743
Pubmed	An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.	RNF31 SCRIB	5.71e-04	25	49	2	37589075
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	DLG3 SYNGAP1	5.71e-04	25	49	2	27480238
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	FLNB CDSN KRT78 AHNAK LAMB3	6.11e-04	488	49	5	31324722
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SMG1 FLNB UBAP2L AHNAK SCRIB	6.70e-04	498	49	5	36634849
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	FLNB SALL2 UBAP2L AHNAK LAMB3	7.00e-04	503	49	5	36217030
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	KRT78 UBAP2L	7.18e-04	28	49	2	20975687
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNB KRT78 UBAP2L DLG3 SCRIB ARHGEF11 CNOT1 SYNGAP1	8.08e-04	1431	49	8	37142655
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	RNF31 AHNAK CNOT1 OTUD7B	8.68e-04	302	49	4	30561431
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	UBAP2L SCRIB CCDC6	8.86e-04	133	49	3	15144186
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FLNB UBQLN1 AHNAK NUP98 PEX5 CCDC6 CNOT1 MVK	9.00e-04	1455	49	8	22863883
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	FLNB UBQLN1 NUP98 SCRIB CNOT1	9.15e-04	534	49	5	35032548
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	FLNB UBAP2L	9.39e-04	32	49	2	27114546
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	UBAP2L HEATR5B CBL CNOT1	1.10e-03	322	49	4	39098523
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	CDSN KRT78 UBQLN1 RNF31 AHNAK	1.11e-03	558	49	5	27591049
Pubmed	Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.	MGMT MAML2	1.12e-03	35	49	2	23192594
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	FLNB AHNAK SCRIB CBL STAT2	1.18e-03	565	49	5	25468996
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	DLG3 SCRIB	1.19e-03	36	49	2	26053890
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	KRT78 DLG3 CNOT1	1.23e-03	149	49	3	22664934
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NEK1 KRT78 AHNAK SCRIB CCDC6 CBL	1.28e-03	861	49	6	36931259
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	FLNB UBAP2L AHNAK	1.30e-03	152	49	3	16009940
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	FLNB AHNAK NUP98 FAAH	1.34e-03	340	49	4	29478914
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	AHNAK ZNF318 CNOT1	1.40e-03	156	49	3	32850835
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNB UBAP2L ARHGEF11 CBL	1.40e-03	344	49	4	30333137
Interaction	FMR1 interactions	SMG1 MEX3A UBAP2L NTRK1 AHNAK SCRIB CNOT1 KCNT1 SYNGAP1	4.96e-06	536	49	9	int:FMR1
Interaction	TDRD3 interactions	SMG1 MEX3A UBQLN1 UBAP2L CCDC6 CNOT1	1.21e-05	212	49	6	int:TDRD3
Interaction	CNOT9 interactions	NEK1 UBAP2L NTRK1 PEX5 ZNF318 CNOT1	1.97e-05	231	49	6	int:CNOT9
Interaction	SQSTM1 interactions	SMG1 FLNB RNF31 UBAP2L NTRK1 AHNAK PEX5 HEATR5B AJUBA CBL CNOT1 OTUD7B	3.51e-05	1257	49	12	int:SQSTM1
Interaction	MEX3A interactions	FLNB MEX3A UBAP2L NTRK1 AHNAK SCRIB CNOT1	3.72e-05	384	49	7	int:MEX3A
Interaction	UNK interactions	SMG1 MEX3A UBQLN1 UBAP2L NUP98 CCDC6 CNOT1	5.46e-05	408	49	7	int:UNK
Interaction	PRRC2C interactions	FLNB MEX3A UBQLN1 UBAP2L NTRK1 AHNAK	7.01e-05	290	49	6	int:PRRC2C
Interaction	EP300 interactions	MEX3A UBQLN1 MGMT KLF1 NUP98 MAML2 SCRIB CCDC6 AJUBA CBL PRDM6 STAT2	1.00e-04	1401	49	12	int:EP300
Interaction	SMG7 interactions	SMG1 SALL2 UBAP2L ZNF318 CCDC6 CNOT1	1.18e-04	319	49	6	int:SMG7
Interaction	RNF214 interactions	SMG1 UBAP2L NTRK1 CNOT1	1.19e-04	104	49	4	int:RNF214
Interaction	ITPRIPL1 interactions	CDSN MEX3A UBQLN1	1.25e-04	40	49	3	int:ITPRIPL1
Interaction	LRRC31 interactions	FLNB KRT78 UBAP2L AHNAK CNOT1	1.37e-04	205	49	5	int:LRRC31
Interaction	CNOT3 interactions	MEX3A UBAP2L NTRK1 CCDC6 CNOT1	1.44e-04	207	49	5	int:CNOT3
Interaction	PHLPP1 interactions	FLNB UBAP2L AHNAK NUP98 ZNF318 SCRIB	1.50e-04	333	49	6	int:PHLPP1
Interaction	CDKL5 interactions	MGMT UBAP2L DLG3 SYNGAP1	1.63e-04	113	49	4	int:CDKL5
Interaction	CCDC8 interactions	FLNB KRT78 AHNAK PEX5 ZNF318 SCRIB HEATR5B CNOT1	1.67e-04	656	49	8	int:CCDC8
Interaction	INPPL1 interactions	NTRK1 AHNAK CCDC6 CBL STAT2	1.68e-04	214	49	5	int:INPPL1
Interaction	ZC3H7A interactions	SMG1 MEX3A UBAP2L NTRK1 CNOT1	1.72e-04	215	49	5	int:ZC3H7A
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	CDSN GTPBP2 ZNF318 SYNGAP1	2.04e-03	503	49	4	chr6p21
GeneFamily	PDZ domain containing	AHNAK DLG3 SCRIB ARHGEF11	1.83e-04	152	34	4	1220
GeneFamily	AAA ATPases\|Peroxins	PEX5 PEX11B	4.05e-04	16	34	2	957
GeneFamily	BPI fold containing	BPIFB4 BPIFA1	4.05e-04	16	34	2	456
GeneFamily	CD molecules\|Tetraspanins	TSPAN10 ROM1	1.75e-03	33	34	2	768
Drug	Pentoxifylline [6493-05-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A	NEK1 PEX5 LAMB3 DLG3 ARHGEF11 CBL	3.76e-06	195	49	6	2290_DN
Drug	3-hydroxy-3-methylglutaric acid	FLNB UBQLN1 PTGER1 FAAH	1.03e-05	63	49	4	CID000001662
Disease	BPI fold-containing family B member 1 measurement	BPIFB4 BPIFA1	5.64e-05	7	49	2	EFO_0801429
Disease	benign neoplasm (implicated_via_orthology)	DLG3 SCRIB	7.52e-05	8	49	2	DOID:0060072 (implicated_via_orthology)
Disease	carcinoma (implicated_via_orthology)	SALL2 DLG3 SCRIB	1.67e-04	64	49	3	DOID:305 (implicated_via_orthology)
Disease	Infantile Refsum Disease (disorder)	PEX5 PEX11B	2.08e-04	13	49	2	C0282527
Disease	Peroxisome biogenesis disorders	PEX5 PEX11B	2.80e-04	15	49	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX5 PEX11B	2.80e-04	15	49	2	C0282525
Disease	Zellweger Syndrome	PEX5 PEX11B	3.19e-04	16	49	2	C0043459
Disease	p-tau:beta-amyloid 1-42 ratio measurement	KRT78 PRDM6	4.54e-04	19	49	2	EFO_0007709
Disease	cancer (implicated_via_orthology)	TSPAN10 DLG3 SCRIB MVK	1.02e-03	268	49	4	DOID:162 (implicated_via_orthology)
Disease	Child Development Disorders, Specific	CBL KCNT1	1.07e-03	29	49	2	C0085997
Disease	Child Development Deviations	CBL KCNT1	1.07e-03	29	49	2	C0085996
Disease	Developmental Disabilities	CBL KCNT1	1.14e-03	30	49	2	C0008073
Disease	atopic dermatitis (is_marker_for)	CDSN NTRK1	1.55e-03	35	49	2	DOID:3310 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQGLGKAAGPGGTGQ	nan	76	Q6ZR03
VATGAVGPGGLLGTG	BPIFB4	161	P59827
GSDGTPGPGKGRLSG	AJUBA	26	Q96IF1
ILKGSGGGEPLGFLG	ABCA9	1351	Q8IUA7
GGGPAVGGTLKARGA	GTPBP2	16	Q9BX10
KSLGGESSGGTTPVG	ARHGEF11	1451	O15085
GATGEIKGPTVGGGL	AHNAK	5466	Q09666
GGGGKSGGIVISPFR	CCDC6	41	Q16204
GVQLCGGGSTGSKGP	CDSN	376	Q15517
HSKGSKPGGVGTGLG	OTUD7B	526	Q6GQQ9
KPGGVGTGLGGSSGT	OTUD7B	531	Q6GQQ9
LGGSSLSPTEGKGSG	NTRK1	471	P04629
PGTLGTGLGAGFGTA	NUP98	426	P52948
GGSGEVKAPFLGSGG	NEK1	416	Q96PY6
GKGAGGPRGSSETVG	GPIHBP1	151	Q8IV16
LGKPGLGGSSGLAGA	MGMT	176	P16455
KTAVSGLTPGSGGLG	KIAA1109	4171	Q2LD37
QSGGGGGGSKLALPT	KCNT1	666	Q5JUK3
KGAGTGGLGLTVEGP	FLNB	1066	O75369
VGVTGTTGPASKGLG	MUC19	2901	Q7Z5P9
GIKGLSAGVTGTTGP	MUC19	5121	Q7Z5P9
GKTGPSAGVTGTTGL	MUC19	5781	Q7Z5P9
GAKGGPAGLGLTPSA	PTGER1	371	P34995
GAGGAGLGPSKRILG	PEX5	446	P50542
IGGKSPVAGVGNGGS	FAM214B	196	Q7L5A3
LGSTCGLGSGKGSPG	KRT78	451	Q8N1N4
GLGGLLTDKVSPTGG	AP5B1	206	Q2VPB7
GAGPLKGSGAAGLLS	PRDM6	31	Q9NQX0
GASGAGLLGGGSVTP	MAML2	16	Q8IZL2
LGEGGDSGGLIPGKS	HEATR5B	1696	Q9P2D3
LSCLGPGTVGTGLGG	KLF1	236	Q13351
ILKPGGGTSGGLLGG	BPIFA1	76	Q9NP55
GGTSGGLLGGLLGKV	BPIFA1	81	Q9NP55
GCPLGGIGGGTITRG	GBA2	151	Q9HCG7
KGPKGLGFSIAGGIG	DLG3	231	Q92796
AGGGGGTGSPKLVAL	LAMB3	756	Q13751
GSGGSGSGGLIGLMK	CBL	16	P22681
EGALIGSGGSPLGLG	FAAH	221	O00519
RLKGSGGGVPGGSET	PEX11B	156	O96011
GTAAGGGGGLILASP	SALL2	131	Q9Y467
GGGGLILASPKLGAT	SALL2	136	Q9Y467
APRQGGLGVVGGKGS	CCDC184	96	Q52MB2
GTKGGAAVAGGRPTG	RXFP3	301	Q9NSD7
GGSGKGSNKGPLGVT	STAT2	411	P52630
PGSRLSSGGGGGGTK	SMG1	6	Q96Q15
GGLGISIAGGKGSTP	SCRIB	736	Q14160
LPVGGLGTGSLTGIG	CNOT1	776	A5YKK6
GLGLGTEGPQGTGGL	RNF31	331	Q96EP0
GTASGGDPLTGLGGV	TECTA	191	O75443
GLDGTKSGGPSGRGT	UBAP2L	156	Q14157
SGGGGGGGLKPSITK	SYNGAP1	1121	Q96PV0
GPLLVAGTAGGGGLL	ROM1	101	Q03395
LTGAGGGGCGITLLK	MVK	331	Q03426
GFSKLGGGGLRSPGG	MEX3A	451	A1L020
PFGLGGLGGLAGLSS	UBQLN1	146	Q9UMX0
GLAVKGSLGSDLGGP	TSPAN10	101	Q9H1Z9
GVDGGGTGCSIPGLS	ZNF318	341	Q5VUA4