Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncargo receptor activity

COLEC12 CD44 LRP1

1.05e-0385473GO:0038024
GeneOntologyMolecularFunctionmethylated histone binding

CBX6 CBX4 CBX8

1.09e-0386473GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

CBX6 CBX4 CBX8

1.17e-0388473GO:0140034
GeneOntologyMolecularFunctionfatty-acyl-CoA binding

ACBD4 ACBD5

1.22e-0322472GO:0000062
GeneOntologyMolecularFunctionfatty acid derivative binding

ACBD4 ACBD5

1.45e-0324472GO:1901567
GeneOntologyMolecularFunctionchromatin binding

TICRR SETDB1 CBX6 POLG CBX4 TOP1 CBX8

1.60e-03739477GO:0003682
GeneOntologyMolecularFunctionacyl-CoA binding

ACBD4 ACBD5

1.70e-0326472GO:0120227
GeneOntologyMolecularFunctionscavenger receptor activity

COLEC12 LRP1

1.83e-0327472GO:0005044
GeneOntologyMolecularFunctionsingle-stranded RNA binding

CBX6 CBX4 CBX8

2.27e-03111473GO:0003727
GeneOntologyCellularComponentPRC1 complex

CBX6 CBX4 CBX8

1.01e-0519473GO:0035102
GeneOntologyCellularComponentsecretory granule

ATP11B VPS13A CD44 LRP1 FGB FUCA2 F5 CTSV PGM2 CTSW

6.93e-0510144710GO:0030141
GeneOntologyCellularComponentsecretory vesicle

ATP11B VPS13A CD44 LRP1 FGB FUCA2 FER1L5 F5 CTSV PGM2 CTSW

7.70e-0512464711GO:0099503
GeneOntologyCellularComponentsecretory granule lumen

VPS13A FGB FUCA2 F5 PGM2 CTSW

8.46e-05325476GO:0034774
GeneOntologyCellularComponentcytoplasmic vesicle lumen

VPS13A FGB FUCA2 F5 PGM2 CTSW

9.21e-05330476GO:0060205
GeneOntologyCellularComponentvesicle lumen

VPS13A FGB FUCA2 F5 PGM2 CTSW

9.52e-05332476GO:0031983
GeneOntologyCellularComponentnuclear ubiquitin ligase complex

CBX6 CBX4 CBX8

1.83e-0449473GO:0000152
GeneOntologyCellularComponentPcG protein complex

CBX6 CBX4 CBX8

2.18e-0452473GO:0031519
GeneOntologyCellularComponentlysosome

NAAA ATP11B MYO6 VPS13A LRP1 FUCA2 CTSV CTSW

4.07e-04811478GO:0005764
GeneOntologyCellularComponentlytic vacuole

NAAA ATP11B MYO6 VPS13A LRP1 FUCA2 CTSV CTSW

4.07e-04811478GO:0000323
GeneOntologyCellularComponentvacuole

NAAA ATP11B MYO6 VPS13A LRP1 FUCA2 CTSV CTSW

8.88e-04913478GO:0005773
GeneOntologyCellularComponentmicrovillus

MYO6 CD44 CTSV

2.67e-03123473GO:0005902
DomainCBX7_C

CBX6 CBX4 CBX8

1.59e-075483IPR033773
DomainCBX7_C

CBX6 CBX4 CBX8

1.59e-075483PF17218
DomainChromodomain_CS

CBX6 CBX4 CBX8

1.27e-0518483IPR023779
DomainChromo_domain

CBX6 CBX4 CBX8

3.10e-0524483IPR023780
DomainChromo

CBX6 CBX4 CBX8

3.97e-0526483PF00385
DomainCHROMO_1

CBX6 CBX4 CBX8

4.99e-0528483PS00598
DomainCHROMO_2

CBX6 CBX4 CBX8

4.99e-0528483PS50013
DomainAcyl-CoA-binding_prot_CS

ACBD4 ACBD5

6.44e-055482IPR022408
DomainChromodomain-like

CBX6 CBX4 CBX8

7.50e-0532483IPR016197
DomainChromo/shadow_dom

CBX6 CBX4 CBX8

8.23e-0533483IPR000953
DomainCHROMO

CBX6 CBX4 CBX8

8.23e-0533483SM00298
DomainInhibitor_I29

CTSV CTSW

1.35e-047482PF08246
DomainProt_inhib_I29

CTSV CTSW

1.35e-047482IPR013201
DomainACB_1

ACBD4 ACBD5

1.35e-047482PS00880
DomainInhibitor_I29

CTSV CTSW

1.35e-047482SM00848
DomainACBP

ACBD4 ACBD5

1.35e-047482PF00887
DomainACB_2

ACBD4 ACBD5

1.35e-047482PS51228
DomainAcyl-CoA-binding_protein

ACBD4 ACBD5

1.79e-048482IPR000582
DomainPept_asp_AS

CTSV CTSW

2.87e-0410482IPR025661
DomainChromo_dom_subgr

CBX6 CBX4

2.87e-0410482IPR017984
DomainPept_his_AS

CTSV CTSW

3.51e-0411482IPR025660
DomainPept_C1

CTSV CTSW

4.95e-0413482SM00645
DomainPeptidase_C1A_C

CTSV CTSW

4.95e-0413482IPR000668
DomainPeptidase_C1

CTSV CTSW

4.95e-0413482PF00112
DomainPeptidase_C1A

CTSV CTSW

4.95e-0413482IPR013128
DomainTHIOL_PROTEASE_CYS

CTSV CTSW

2.02e-0326482PS00139
DomainTHIOL_PROTEASE_ASN

CTSV CTSW

2.18e-0327482PS00640
DomainTHIOL_PROTEASE_HIS

CTSV CTSW

2.18e-0327482PS00639
DomainPept_cys_AS

CTSV CTSW

2.34e-0328482IPR000169
PathwayKEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119

CBX6 CBX4 CBX8

5.26e-0526403M47923
PathwayREACTOME_PEROXISOMAL_LIPID_METABOLISM

ACBD4 ACBD5 HACL1

6.60e-0528403MM15010
PathwayREACTOME_PEROXISOMAL_LIPID_METABOLISM

ACBD4 ACBD5 HACL1

7.35e-0529403M2286
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

CBX6 CBX4 CBX8

1.19e-0434403MM15531
PathwayREACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN

CBX6 CBX4 CBX8

1.54e-0437403M27797
PathwayKEGG_MEDICUS_REFERENCE_GENE_SILENCING_BY_METHYLATION_OF_H3K27_AND_UBIQUITINATION_OF_H2AK119

CBX6 CBX4 CBX8

1.94e-0440403M47917
PathwayBIOCARTA_EXTRINSIC_PATHWAY

FGB F5

6.00e-0413402M4470
PathwayBIOCARTA_EXTRINSIC_PATHWAY

FGB F5

6.00e-0413402MM1395
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

CBX6 CBX4 CBX8

6.80e-0461403M27811
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

CBX6 CBX4 CTSV CBX8

9.00e-04153404MM15522
PathwayREACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS

CBX4 CBX8

9.19e-0416402M27403
PathwayREACTOME_FATTY_ACID_METABOLISM

ACBD4 ACBD5 HACL1 ALOX15B

1.33e-03170404MM15573
PathwayREACTOME_FATTY_ACID_METABOLISM

ACBD4 ACBD5 HACL1 ALOX15B

1.51e-03176404M27854
PathwayREACTOME_METABOLISM_OF_LIPIDS

B3GALNT1 ACBD4 ACBD5 HACL1 PTDSS2 ALOX15B ACSS3

1.62e-03620407MM15193
PathwayWP_BLOOD_CLOTTING_CASCADE

FGB F5

1.75e-0322402M39480
PathwayREACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION

FGB F5

1.75e-0322402M17879
PathwayREACTOME_COMMON_PATHWAY_OF_FIBRIN_CLOT_FORMATION

FGB F5

1.75e-0322402MM14558
PathwayBIOCARTA_INTRINSIC_PATHWAY

FGB F5

1.91e-0323402M15997
PathwayBIOCARTA_INTRINSIC_PATHWAY

FGB F5

1.91e-0323402MM1427
PathwayWP_BLOOD_CLOTTING_CASCADE

FGB F5

1.91e-0323402MM15936
Pubmed

Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.

CBX6 CBX4 CBX8

2.19e-07949318927235
Pubmed

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.

CBX6 CBX4 CBX8

3.13e-071049316537902
Pubmed

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.

CBX6 CBX4 CBX8

1.18e-061549320601937
Pubmed

Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.

SETDB1 CBX6 CBX4 CBX8

1.30e-065749417296600
Pubmed

Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism.

ACBD4 ACBD5

1.94e-06249237414147
Pubmed

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.

CD44 TOP1

1.94e-06249224960044
Pubmed

Mesenchymal subtype of glioblastomas with high DNA-PKcs expression is associated with better response to radiotherapy and temozolomide.

CD44 PRKDC

1.94e-06249228070830
Pubmed

LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.

CD44 LRP1

1.94e-06249222711991
Pubmed

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

PRKDC TOP1

1.94e-06249226578593
Pubmed

Identification and analysis of a third mouse Polycomb gene, MPc3.

CBX4 CBX8

1.94e-06249210721694
Pubmed

TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity.

CD44 PRKDC

1.94e-06249223349496
Pubmed

Associations of the beta-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis.

FGB F5

5.83e-06349217582472
Pubmed

Epithelial membrane protein 3 regulates TGF-β signaling activation in CD44-high glioblastoma.

CD44 EMP3

5.83e-06349227527869
Pubmed

Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.

LRP1 F5

5.83e-06349217155964
Pubmed

Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes.

LRP1 F5

5.83e-06349225800007
Pubmed

Genetic variations observed in arterial and venous thromboembolism--relevance for therapy, risk prevention and prognosis.

FGB F5

5.83e-06349212747593
Pubmed

PRC1 components exhibit different binding kinetics in Polycomb bodies.

CBX4 CBX8

5.83e-06349224460908
Pubmed

Advanced age, low left atrial appendage velocity, and factor V promoter sequence variation as predictors of left atrial thrombosis in patients with nonvalvular atrial fibrillation.

FGB F5

5.83e-06349220082208
Pubmed

Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.

CBX6 CBX4 CBX8

1.04e-053049337158107
Pubmed

Influence of Amerindian mitochondrial DNA haplogroups on thrombosis susceptibility and frequency of four genetic prothrombotic variants in Southern Chilean subjects.

FGB F5

1.16e-05449220064497
Pubmed

Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis.

FGB F5

1.16e-05449218253477
Pubmed

PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow.

CD44 FGB

1.16e-05449223056168
Pubmed

The effect of four hemostatic gene polymorphisms on the outcome of septic critically ill patients.

FGB F5

1.16e-05449220051843
Pubmed

-455G/A beta-fibrinogen gene polymorphism, factor V Leiden, prothrombin G20210A mutation and MTHFR C677T, and placental vascular complications.

FGB F5

1.16e-05449215091001
Pubmed

Thrombophilic gene polymorphisms and recurrent pregnancy loss in Greek women.

FGB F5

1.94e-05549228603947
Pubmed

[Associations of hemostasis factors genes with early development of ischemic heart disease and manifestation of myocardial infarction in young age].

FGB F5

1.94e-05549216353042
Pubmed

Polymorphisms in coagulation factors and the risk of recurrent cardiovascular events in men after a first myocardial infarction.

FGB F5

1.94e-05549218284606
Pubmed

Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study.

FGB F5

1.94e-05549214963283
Pubmed

[Genetics of blood coagulation in young stroke patients].

FGB F5

1.94e-05549212122980
Pubmed

PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

CBX6 CBX4 CBX8

2.70e-054149322325352
Pubmed

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.

CBX4 CBX8

2.91e-05649217332741
Pubmed

Connection between genetically determined blood coagulation factors and haemorheology.

FGB F5

2.91e-05649218503143
Pubmed

Spectrum and prevalence of prothrombotic single nucleotide polymorphism profiles in the Greek Cypriot population.

FGB F5

2.91e-05649212518110
Pubmed

Prothrombotic phenotype of protein Z deficiency.

FGB F5

2.91e-05649210829076
Pubmed

[Pharmacogenetics of the local thrombolysis in patients with deep vein thrombosis].

FGB F5

2.91e-05649216466010
Pubmed

USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.

CBX6 CBX4

2.91e-05649228839133
Pubmed

Mutations and polymorphisms in genes affecting haemostasis components in children with thromboembolic events.

FGB F5

2.91e-05649217230042
Pubmed

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

PRKDC TOP1

2.91e-05649228415827
Pubmed

Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss?

FGB F5

2.91e-05649216938111
Pubmed

Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin.

FGB F5

2.91e-05649217994314
Pubmed

Role of thrombophilic gene polymorphisms in branch retinal vein occlusion.

FGB F5

2.91e-05649216157382
Pubmed

Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke.

FGB F5

4.07e-05749216567932
Pubmed

Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population.

FGB F5

4.07e-05749215968394
Pubmed

Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage.

FGB F5

4.07e-05749216635210
Pubmed

Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension.

FGB F5

4.07e-05749218057060
Pubmed

Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia.

FGB F5

4.07e-05749219395327
Pubmed

A role of TNF-alpha gene variant on juvenile ischemic stroke: a case-control study.

FGB F5

4.07e-05749216324093
Pubmed

Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.

PRKDC TOP1

4.07e-05749212519782
Pubmed

Thrombophilic gene polymorphisms are risk factors for unexplained infertility.

FGB F5

4.07e-05749218930220
Pubmed

Replication of findings on the association of genetic variation in 24 hemostasis genes and risk of incident venous thrombosis.

FGB F5

4.07e-05749219682239
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

SETDB1 NAAA MYO6 CBX6 CLK1 ACBD5 VPS13A HACL1 SOCS7

5.20e-05124249930973865
Pubmed

A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.

MYO6 CLK1 PRKDC

5.22e-055149334316707
Pubmed

Recognition and specificity determinants of the human cbx chromodomains.

CBX6 CBX8

5.42e-05849221047797
Pubmed

Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.

UBR5 CBX4

5.42e-05849220351170
Pubmed

Huntingtin facilitates polycomb repressive complex 2.

CBX4 CBX8

5.42e-05849219933700
Pubmed

Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.

PRKDC TOP1

5.42e-05849215640154
Pubmed

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.

POLG SMG6

6.96e-05949216488880
Pubmed

Impact of genetic polymorphisms on platelet function and aspirin resistance.

FGB F5

6.96e-05949219923980
Pubmed

Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis.

FGB F5

6.96e-05949216420563
Pubmed

Candidate genetic markers and the risk of restenosis after coronary angioplasty.

FGB F5

6.96e-05949212899665
Pubmed

No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age.

FGB F5

6.96e-05949212615788
Pubmed

Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study.

FGB F5

8.69e-051049214706682
Pubmed

A prospective case-control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss.

FGB F5

8.69e-051049219906129
Pubmed

Vascular at-risk genotypes and disease severity in Lebanese sickle cell disease patients.

FGB F5

8.69e-051049220425806
Pubmed

Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women.

FGB F5

8.69e-051049219560472
Pubmed

Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.

CBX4 CBX8

8.69e-051049216786585
Pubmed

Prevalence of prothrombotic polymorphisms in Greece.

FGB F5

8.69e-051049219072566
Pubmed

Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction.

FGB F5

8.69e-051049220036902
Pubmed

A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey.

FGB F5

8.69e-051049217111197
Pubmed

MRE11 complex links RECQ5 helicase to sites of DNA damage.

UBR5 PRKDC

1.06e-041149219270065
Pubmed

Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction.

FGB F5

1.27e-041249212514663
Pubmed

Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

CBX4 CBX8

1.27e-041249219636380
Pubmed

Gene variants associated with venous thrombosis: confirmation in the MEGA study.

FGB F5

1.27e-041249220128871
Pubmed

Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.

PRKDC TOP1

1.27e-041249221679440
Pubmed

Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.

CBX6 CBX8

1.27e-041249220543829
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

THSD7A LRP1 PBXIP1

1.40e-047149333541421
Pubmed

Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin.

FGB F5

1.50e-041349218848323
Pubmed

Genetic influences on blood pressure within the Stanislas Cohort.

FGB F5

1.50e-041349215076187
Pubmed

Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population.

FGB F5

1.50e-041349217003923
Pubmed

Genetic cardiovascular risk factors and age-related macular degeneration.

FGB F5

1.50e-041349219860767
Pubmed

BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.

UBR5 CBX4

1.50e-041349227647897
Pubmed

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.

FGB F5

1.75e-041449220078877
Pubmed

Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.

CD44 LRP1

1.75e-041449219299737
Pubmed

Functional proteomics mapping of a human signaling pathway.

SETDB1 THSD7A UBR5 MYO6 LRP1 CBX4

1.77e-0459149615231748
Pubmed

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

CBX4 CBX8

2.30e-041649212167701
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

UBR5 PRKDC TOP1

2.56e-048749317148452
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

MYO6 CD44 PRKDC EMP3 F5 TOP1

3.19e-0466049632780723
Pubmed

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

PRKDC TOP1

3.27e-041949220504901
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SETDB1 MYO6 CLK1 POLG LRP1 PRKDC PBXIP1 TOP1

3.98e-04128549835914814
Pubmed

A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.

CD44 PGM2

4.01e-04214924042679
Pubmed

Candidate genes and cerebral palsy: a population-based study.

FGB F5

4.01e-042149218977990
Pubmed

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.

CBX4 CBX8

4.01e-042149237014752
Pubmed

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.

CBX4 CBX8

4.01e-042149218311137
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

THSD7A ATP11B VPS13A

4.09e-0410249310231032
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

B3GALNT1 FBXO25 POLG LRP1 SOCS7

4.23e-0445049516751776
Pubmed

The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.

UBR5 PRKDC TOP1

4.33e-0410449331365120
Pubmed

Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.

FGB F5

4.41e-042249212871600
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CD44 LRP1 FGB F5

4.75e-0425749416335952
Pubmed

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

CBX6 CBX4 CBX8

5.96e-0411649321282530
Pubmed

Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.

FGB F5

6.18e-042649221054877
Cytoband17p13.1

CYB5D1 GSG1L2 ALOX15B

2.80e-0411849317p13.1
CytobandEnsembl 112 genes in cytogenetic band chr17p13

CYB5D1 GSG1L2 ALOX15B SMG6

5.14e-04346494chr17p13
GeneFamilyChromobox family

CBX6 CBX4 CBX8

2.30e-078303976
GeneFamilyCathepsins

CTSV CTSW

2.76e-0415302470
GeneFamilyGlycosyltransferase family 6|Blood group antigens

B3GALNT1 CD44

1.71e-0337302454
CoexpressionGSE17721_POLYIC_VS_PAM3CSK4_24H_BMDC_UP

COLEC12 NAAA ATP11B CBX6 FUCA2 F5

1.47e-06199476M3846
CoexpressionGSE20500_CTRL_VS_RETINOIC_ACID_TREATED_CD4_TCELL_DN

MYO6 CLK1 FGB CBX4 CTSV

2.77e-05198475M7701
CoexpressionGSE3982_EFF_MEMORY_CD4_TCELL_VS_TH2_UP

MYO6 CD44 PBXIP1 ALOX15B ACSS3

2.77e-05198475M5580
CoexpressionGSE32164_RESTING_DIFFERENTIATED_VS_CMYC_INHIBITED_MACROPHAGE_DN

GPR65 MYO6 CBX6 CD44 CTSV

2.91e-05200475M8531
CoexpressionGSE8621_LPS_STIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN

B3GALNT1 TICRR GPR65 CD44 LRP1

2.91e-05200475M6983
CoexpressionGRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN

BNIP3 NAAA PGM2 CBX8 SPATA13

6.65e-05238475M1098
CoexpressionGRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN

BNIP3 NAAA PGM2 CBX8 SPATA13

8.23e-05249475MM1092
CoexpressionFAN_EMBRYONIC_CTX_BRAIN_EFFECTOR_T_CELL

GPR65 CD44 EMP3 CTSW

9.27e-05132474M39046
CoexpressionBOCHKIS_FOXA2_TARGETS

COLEC12 BNIP3 LRP1 FGB HACL1 PRKDC

1.20e-04434476M1806
CoexpressionGSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD8_TCELL_UP

NAAA HACL1 EMP3 CBX8

1.40e-04147474M6765
CoexpressionGABRIELY_MIR21_TARGETS

B3GALNT1 ATP11B UBR5 ACBD5 VPS13A

1.65e-04289475M2196
CoexpressionCARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP

B3GALNT1 COLEC12 TICRR CBX6 PRKDC CTSV PBXIP1 ALOX15B

1.68e-04891478M45033
CoexpressionJOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN

THSD7A EMP3 SULT1E1

1.72e-0460473M1515
CoexpressionCUI_DEVELOPING_HEART_C9_B_T_CELL

GPR65 CLK1 CD44 CTSW

1.72e-04155474M39306
CoexpressionBOCHKIS_FOXA2_TARGETS

COLEC12 BNIP3 LRP1 FGB HACL1 PRKDC

1.79e-04467476MM1233
CoexpressionNAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN

ATP11B CLK1 CD44 CBX4 PBXIP1 TOP1 SPATA13

1.96e-04680477M41089
CoexpressionDURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_MAST_CELLS

GPR65 CD44 EMP3

3.20e-0474473M39294
CoexpressionLEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP

BNIP3 NAIP CTSV

3.20e-0474473M515
CoexpressionGSE21360_TERTIARY_VS_QUATERNARY_MEMORY_CD8_TCELL_UP

COLEC12 NAAA ACBD5 LRP1

3.24e-04183474M7635
CoexpressionBLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_DN

FGB CTSV PBXIP1

3.47e-0476473M34019
CoexpressionGSE34156_UNTREATED_VS_24H_NOD2_LIGAND_TREATED_MONOCYTE_UP

B3GALNT1 VPS13A PRKDC SMG6

3.81e-04191474M8681
CoexpressionGSE37416_CTRL_VS_3H_F_TULARENSIS_LVS_NEUTROPHIL_DN

FUT11 BNIP3 CLK1 CYB5D1

4.13e-04195474M5330
CoexpressionGSE45365_WT_VS_IFNAR_KO_BCELL_UP

POLG ACBD5 EMP3 ALOX15B

4.13e-04195474M9984
CoexpressionGSE360_T_GONDII_VS_B_MALAYI_LOW_DOSE_DC_UP

BNIP3 THSD7A CLK1 ALOX15B

4.29e-04197474M5217
CoexpressionGSE33292_DN3_THYMOCYTE_VS_TCF1_KO_TCELL_LYMPHOMA_UP

BNIP3 NAAA GPR65 CD44

4.45e-04199474M9424
CoexpressionGSE30083_SP1_VS_SP4_THYMOCYTE_DN

ATP11B CD44 PRKDC CTSW

4.54e-04200474M5030
CoexpressionGSE14308_TH1_VS_TH17_DN

UBR5 CBX6 CD44 PRKDC

4.54e-04200474M3374
CoexpressionGSE11961_MEMORY_BCELL_DAY7_VS_MEMORY_BCELL_DAY40_DN

B3GALNT1 MYO6 EMP3 PGM2

4.54e-04200474M9357
CoexpressionGSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA5_STIM_CD8_TCELL_UP

FBXO25 CLK1 TOP1 SOCS7

4.54e-04200474M8050
CoexpressionGSE27786_BCELL_VS_NKCELL_DN

B3GALNT1 CD44 EMP3 F5

4.54e-04200474M4806
CoexpressionGSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP

FBXO25 UBR5 CD44 SOCS7

4.54e-04200474M4827
CoexpressionGSE3920_UNTREATED_VS_IFNB_TREATED_ENDOTHELIAL_CELL_UP

FUT11 NAAA PBXIP1 SMG6

4.54e-04200474M6686
CoexpressionGSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY7_DN

CBX6 LRP1 CTSW SOCS7

4.54e-04200474M6585
CoexpressionGSE1432_6H_VS_24H_IFNG_MICROGLIA_UP

B3GALNT1 PTDSS2 EMP3 TOP1

4.54e-04200474M3415
CoexpressionGSE18893_CTRL_VS_TNF_TREATED_TREG_2H_UP

UBR5 F5 CTSV SPATA13

4.54e-04200474M7294
CoexpressionGSE17721_CTRL_VS_LPS_0.5H_BMDC_UP

ATP11B FUCA2 EMP3 F5

4.54e-04200474M3679
CoexpressionGSE40274_XBP1_VS_FOXP3_AND_XBP1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

FUT11 ACBD4 EMP3 PBXIP1

4.54e-04200474M9161
CoexpressionDURANTE_ADULT_OLFACTORY_NEUROEPITHELIUM_NK_CELLS

GPR65 EMP3 CTSW

4.65e-0484473M39287
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TICRR NAAA WDR87 CD44 LRP1

9.54e-07162495d712bc31840ad1523e3dbf884acbb428a8995001
ToppCellfacs-Lung-EPCAM|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAAA CD44 LRP1 EMP3 PBXIP1

2.14e-0619149500957dd6077e107722835084d769e84eace0611f
ToppCellfacs-Lung-EPCAM-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 NAAA LRP1 EMP3 PBXIP1

2.26e-06193495b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

TICRR NAIP LRP1 F5

2.12e-05148494de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

B3GALNT1 CD44 USP35 CTSW

2.24e-05150494580ed7733857402345f43ca2623f72cdd1edf22c
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAAA WDR87 CD44 LRP1

2.74e-051584946811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR65 CD44 EMP3 CTSW

2.95e-0516149454eda81a570e422b35fcea799e640c7654122969
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR GPR65 CD44 EMP3

3.41e-0516749441675d15919104c9e20cd97620fe636f3ff33fa9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR GPR65 CD44 EMP3

3.41e-051674943d5a6a4c7d037b1a6a8ec90034d88ef6d256e843
ToppCellMonocytes-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

NAAA NAIP EMP3 F5

3.49e-051684949ea3c682ce4e98f1a3303f99b4c63c2cf8863abc
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-MAIT_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 EMP3 PBXIP1 CTSW

3.65e-05170494059f7ae615342ea19f43b0a405cd7272251a78a9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TICRR GPR65 CD44 EMP3

3.73e-05171494c60313b045cb77c0923ddb81bbd1a654aa1087c5
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-ILC3|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 CD44 PBXIP1 CTSW

3.73e-051714946ab7f103cbdbd49ef687cbb8a42ddc5517af0f7f
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR65 CD44 EMP3 F5

3.82e-05172494e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD44 F5 PBXIP1 CCDC144NL

3.82e-05172494c74c1d47b133eb5d0f762a06e421252a76b4672b
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GPR65 CD44 EMP3 F5

3.82e-0517249483730ea3b240b8e2f2a9fb6c34dd1408050867ff
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR65 CD44 EMP3 CTSW

4.18e-0517649427c5ddd67de52101360ef7de8fcfa041066d97db
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Mast_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 CD44 USP35 EMP3

4.27e-0517749415553c7cd7826c80086daa76af4224f32dde53a6
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Treg|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CBX6 CD44 F5 PBXIP1

4.37e-05178494e37142a84d9713ff1571ce9f976842bf5c17c86f
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COLEC12 LRP1 ACSS3 SULT1E1

4.56e-0518049408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CBX6 NAIP ALOX15B ACSS3

4.56e-0518049466c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCellP28-Mesenchymal-mesenchymal_fibroblast|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COLEC12 LRP1 EMP3 CTSV

4.66e-05181494091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCellP28-Mesenchymal|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COLEC12 LRP1 EMP3 CTSV

4.76e-0518249469f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

THSD7A NAIP FGB F5

4.97e-051844947ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-MAIT_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 CD44 PBXIP1 CTSW

5.07e-051854948314dc608bc837df3037e89afd9db39737374ebc
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILC3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GPR65 CD44 PBXIP1 CTSW

5.18e-05186494ac1d2a94674bd15885e70502abad3a2ff3c21d73
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILC3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GPR65 CD44 PBXIP1 CTSW

5.29e-05187494a037631a01d2cce088e6522dceeb1eee806522a1
ToppCellP15-Mesenchymal|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COLEC12 LRP1 EMP3 CTSV

5.40e-05188494f1ba0b661621a65c91432e62ba73531bdf18e7c1
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Mast_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR65 CD44 EMP3 SPATA13

5.40e-051884943fe9d698ff8f540edebf8609e7d42d3f81271edb
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

B3GALNT1 MYO6 NAIP EMP3

5.40e-051884941aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 LRP1 ACSS3 SULT1E1

5.51e-05189494544d95df910f1b276995624509a7e41b219baca0
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COLEC12 LRP1 ACSS3 SULT1E1

5.51e-05189494a153b83314cf52808f685296cff8c95af3f4983d
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPR65 CLK1 CD44 EMP3

5.51e-05189494d26af19fd7e0c7eb78a5a3a245ca5229c4e9e847
ToppCellfacs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 THSD7A LRP1 SULT1E1

5.63e-05190494dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCellfacs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 THSD7A LRP1 SULT1E1

5.63e-051904940bb06df3d5a50416854370f234718c6cec3d773b
ToppCellfacs-SCAT-Fat-24m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 THSD7A LRP1 SULT1E1

5.63e-05190494008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Tem/emra_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

GPR65 MYO6 EMP3 CTSW

5.63e-0519049466d29f53f129fc18771f6214316a913eeaccd55e
ToppCell(0)_T_CD4|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

GPR65 EMP3 PBXIP1 CTSW

5.74e-05191494ba289658777a2669fda9da9128e87adb60fd8430
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 THSD7A LRP1 EMP3

5.86e-051924945e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COLEC12 LRP1 ACSS3 SULT1E1

5.86e-05192494dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR65 FGB CYB5D1 ALOX15B

5.86e-05192494181d22fbb98a619a7f302c0f6623cee94c49a253
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COLEC12 THSD7A LRP1 EMP3

5.86e-05192494136af0186c70c14c5f2b33ed7a148156de5b478c
ToppCellCOVID-19_Severe-CD8+_T_activated|World / disease group, cell group and cell class

GPR65 MYO6 EMP3 CTSW

5.98e-05193494ddc1db516568e03be8e82b2ca770c67756418185
ToppCellControl-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

COLEC12 CD44 TOP1 ALOX15B

6.10e-05194494a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COLEC12 THSD7A LRP1 SULT1E1

6.22e-051954941cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

WDR87 F5 CTSW

6.31e-05704932121ba6a0beb2a8fdc589ff1063e7d8c2c3c68f6
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

WDR87 F5 CTSW

6.31e-0570493cd6bca68fe52f451716fc8c0b1745984bc9ec057
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

WDR87 F5 CTSW

6.31e-0570493be300c0447735aba89df4c3082b81eb5abf22770
ToppCelllymphoid-T_cell-unlabelled(multiplets)|World / Lineage, cell class and subclass

CLK1 CD44 EMP3 CTSW

6.35e-0519649478b006922307c154622d71fcbc79ae5eed3f4b23
ToppCellhealthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

FUT11 MYO6 CTSW SPATA13

6.35e-05196494af00c31612e4fe068e5fccae05368edba46bbd20
ToppCellPCW_07-8.5-Mesenchymal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

COLEC12 LRP1 EMP3 SULT1E1

6.35e-051964948e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COLEC12 THSD7A LRP1 SULT1E1

6.35e-051964941450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell(1)_T_CD8_MAIT|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

GPR65 EMP3 PBXIP1 CTSW

6.35e-051964945fc99a8e3dde12fd0b0b2e0a2db48ac16b42739e
ToppCell(0)_Myeloid-(000)_CD14+_Monocyte|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)

NAIP CD44 LRP1 F5

6.35e-05196494e9718642ee2751c9d46a1b968547bdcb59cdfd30
ToppCelllymphoid-T_cell-unlabelled(multiplets)|T_cell / Lineage, cell class and subclass

CLK1 CD44 EMP3 CTSW

6.47e-05197494f215435aee15f0ed254104bfd55670144b6d2ac3
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COLEC12 THSD7A LRP1 SULT1E1

6.47e-0519749431a1852911bda38543916585fda34255fd62a134
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COLEC12 GPR65 NAIP LRP1

6.47e-05197494dc56bb758c7c5bd151be66f8f3b7078d085f72c7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COLEC12 GPR65 NAIP LRP1

6.47e-051974942efb5acd56b96e5afd8d72b927f1d53cc443766f
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NAIP CD44 LRP1 EMP3

6.47e-05197494df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCellT/NK_cells-NKT_cell|T/NK_cells / Lineage and Cell class

GPR65 MYO6 EMP3 CTSW

6.47e-0519749410702e61b510bfc7f54047ab3d8c700451a662b2
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NAAA LRP1 EMP3 ALOX15B

6.60e-0519849474591eba5dbb2d77d416309326a26be969e4ad42
ToppCellbackground-T_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

CD44 FGB EMP3 CTSW

6.60e-05198494bf1b249b531f059f7edb4b27ff90c97cfc51bd8a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COLEC12 THSD7A LRP1 SULT1E1

6.60e-0519849417dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

GPR65 NAIP CD44 EMP3

6.60e-05198494684f2dd5db889f118b5218ee23733cc1361272c2
ToppCellControl_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|Control_saline / Treatment groups by lineage, cell group, cell type

GPR65 NAIP CD44 EMP3

6.60e-05198494c15ab0660a6de445a83396cf70860ea39868914d
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COLEC12 LRP1 CBX4 CYB5D1

6.60e-0519849493cc01d91ffc543fd1a717ef47e02e532b50b665
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GPR65 CD44 EMP3 CTSW

6.60e-05198494be4ef274fda0498e3ddac554cf9df1b21cc32ba6
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NAAA LRP1 EMP3 ALOX15B

6.60e-051984943e1e79bb7b13540a06956b59c6a62984efea19ee
ToppCelldistal-Hematologic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR65 CD44 EMP3 CTSW

6.60e-0519849466360d51c19650332a4a982818b668233a7f080b
ToppCellCOVID-19_Mild-Classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

NAIP CD44 LRP1 F5

6.60e-0519849430ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCellSevere_COVID-19-Myeloid-MoAM3|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

NAIP CD44 LRP1 EMP3

6.73e-0519949430523cf08815ca214877e33a2c52197ff8318557
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NAIP CD44 LRP1 EMP3

6.73e-05199494105709b97c55826a852aed27658e3b4af1738c8a
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_3|COVID-19_Severe / Disease condition and Cell class

NAIP CD44 LRP1 F5

6.73e-05199494ffb2ef9b7006cbed0f43637af040719b9776cbd5
ToppCellLPS_only|World / Treatment groups by lineage, cell group, cell type

GPR65 CD44 TOP1 SPATA13

6.73e-05199494852cf595c2255983cff9045f2bb746d4391cf5ba
ToppCellMS-IIF-Lymphocyte-T/NK-NK_CD56bright|IIF / Disease, condition lineage and cell class

B3GALNT1 GPR65 CD44 CTSW

6.73e-051994949eb2b7d4900b118338590db778a47504559e228d
ToppCell15-Trachea-Immune-Hematopoietic,_T_Cells|Trachea / Age, Tissue, Lineage and Cell class

GPR65 CD44 EMP3 CTSW

6.73e-05199494d5dcf7b4f58a075a7f729165556f7666e6b4c104
ToppCellLPS_only-Hematopoietic_Myeloid|LPS_only / Treatment groups by lineage, cell group, cell type

GPR65 CD44 EMP3 SPATA13

6.73e-0519949420523dee39a4c5f6423259920f108127b47525c4
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NAIP CD44 LRP1 EMP3

6.73e-051994940892957a49304ce4b6daa3657d76d8365ce0dd19
ToppCellControl_saline-Hematopoietic_Myeloid|Control_saline / Treatment groups by lineage, cell group, cell type

GPR65 NAIP CD44 EMP3

6.73e-051994946be92062cce049a4c98f7311f2500bf1468fc267
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NAIP CD44 LRP1 EMP3

6.73e-05199494b2dc3d0af6ecd3ab01779aaa1f061cb0f941cae8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COLEC12 GPR65 NAIP LRP1

6.73e-05199494ca0f6526ba0dcf8789dd3b583291519626427f2f
ToppCellCOVID-19_Severe-Classical_Monocyte|COVID-19_Severe / Disease condition and Cell class

NAIP CD44 LRP1 F5

6.73e-05199494ea1e2ccde3930fab6d04a9bf130837455c742474
ToppCell10x3'2.3-week_17-19-Myeloid_monocytic-monocyte-CD14_monocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NAIP CD44 EMP3 F5

6.73e-0519949450a30d5ee99e51743a0dd60144fc341ff68da9af
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NAIP CD44 LRP1 EMP3

6.73e-05199494961ad44199871be8e09d31904d383edc865ba262
ToppCelldistal-3-Hematologic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GPR65 CD44 EMP3 CTSW

6.73e-051994940324eb076ffe6befab03d7a9ea389a94f0644448
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR65 MYO6 EMP3 CTSW

6.73e-0519949400ef3cc5c02639bfb839075ecf5f20026ff81f84
ToppCellBiopsy_Control_(H.)-Immune|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

GPR65 CD44 LRP1 EMP3

6.86e-05200494e1d50556ca116ef4b65ec29ab2ef7341f0d21451
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NAAA GPR65 EMP3 F5

6.86e-052004942200a621da1634728a49b1706e422e3e78b1f3bf
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

NAIP CD44 LRP1 EMP3

6.86e-05200494bffebc281a5c1c2bfdb2696a45343787289fc374
ToppCell10x5'v1-week_14-16-Myeloid_monocytic-monocyte-CD14_monocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NAIP CD44 LRP1 EMP3

6.86e-05200494f65837b51bce94c08125b1a2e1a696a15267f64b
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Radial_glial-RG|6_mon / Sample Type, Dataset, Time_group, and Cell type.

BNIP3 CD44 EMP3 PBXIP1

6.86e-05200494fb7c9c0e4beadad6e41e68f6f889e56650898d22
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Radial_glial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

BNIP3 CD44 EMP3 PBXIP1

6.86e-05200494fff209256805a448393c385b79a70c2e2172e49c
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-5|TCGA-Breast / Sample_Type by Project: Shred V9

CBX4 FUCA2 CBX8

1.88e-04101493f4db710b2510cdbee26dd5c3b581c85fe6f0be00
ToppCellControl-CD8+_T_activated|World / Disease group and Cell class

ACBD4 CYB5D1 CTSW

3.04e-0411949383c3e2bb71b947facbfbef635550901f33c8c26a
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

TICRR POLG LRP1

3.27e-041224931ed865f0ecfe304fb86313ff51c04e9052357270
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular|TCGA-Stomach / Sample_Type by Project: Shred V9

TMEM260 TICRR F5

4.69e-0413849393497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCellSmart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MYO6 CBX6 CTSW

4.79e-04139493a542ef99ba57f364ea9707b3119e11f5a240034c
ToppCelldroplet-Liver-Npc-18m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNIP3 FGB HACL1

5.75e-041484934ccf87f3e0d2c61148285979ae92cd41778fa321
ToppCelldroplet-Liver-Npc-18m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNIP3 FGB HACL1

5.75e-04148493981e205cc8a6f6d2a35dc95c5a93ed9193a236b9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TICRR USP35 CBX8

5.75e-041484936cd7ef4f29d9a0944f724d9d8117d4d25e517fe4
DrugCV-3988

CLK1 CD44 ALOX15B

2.08e-0525493CID000107681
Drug2oym

CD44 LRP1 TOP1

3.29e-0529493CID015959255
DrugE64A

FUCA2 CTSV CTSW

4.04e-0531493CID000173548
Drugdesmedipham

FUCA2 CTSV CTSW

4.04e-0531493CID000024743
DrugKm 201

MYO6 CD44

4.52e-055492CID000089125
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

ATP11B UBR5 POLG CD44 PRKDC

5.57e-051914954168_DN
DrugLiothyronine [6893-02-3]; Down 200; 6.2uM; PC3; HT_HG-U133A

SETDB1 LRP1 EMP3 PBXIP1 SMG6

6.30e-051964956602_DN
DrugFlutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

ACBD4 VPS13A CD44 PTDSS2 SMG6

6.45e-051974953885_DN
DrugTalampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A

NAAA CBX6 CBX4 F5 CBX8

6.45e-051974957014_UP
DrugAzathymine, 6 [932-53-6]; Up 200; 31.4uM; HL60; HT_HG-U133A

THSD7A LRP1 FGB CBX8 SMG6

6.45e-051974952466_UP
DrugGibberellic acid [77-06-5]; Up 200; 11.6uM; HL60; HT_HG-U133A

NAAA ACBD4 CTSV PBXIP1 CBX8

6.61e-051984952910_UP
DrugNisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; HL60; HT_HG-U133A

NAAA POLG CD44 CBX4 CTSV

6.61e-051984953117_DN
DrugCephapirin sodium salt [24356-60-3]; Up 200; 9uM; MCF7; HT_HG-U133A

NAAA VPS13A EMP3 F5 SMG6

6.77e-051994956790_UP
Drugorpanoxin

NAAA ALOX15B

6.77e-056492CID000043382
Diseasegastric adenocarcinoma (is_implicated_in)

UBR5 CD44

1.41e-0411482DOID:3717 (is_implicated_in)
Diseasethrombosis (is_implicated_in)

FGB F5

2.68e-0415482DOID:0060903 (is_implicated_in)
DiseasePolyposis, Adenomatous Intestinal

CD44 F5

3.06e-0416482C2713442
DiseaseFamilial Intestinal Polyposis

CD44 F5

3.06e-0416482C2713443
DiseaseAdenomatous Polyposis Coli

CD44 F5

3.47e-0417482C0032580
Diseasemyocardial infarction (is_implicated_in)

LRP1 FGB F5

5.68e-0499483DOID:5844 (is_implicated_in)
Diseasemigraine disorder, pulse pressure measurement

LRP1 SMG6

8.21e-0426482EFO_0005763, MONDO_0005277
Diseasecancer (implicated_via_orthology)

CBX6 CBX4 TOP1 CBX8

9.46e-04268484DOID:162 (implicated_via_orthology)
DiseaseD dimer measurement

FGB F5

1.09e-0330482EFO_0004507
Diseasesensorineural hearing loss (is_implicated_in)

MYO6 F5

1.32e-0333482DOID:10003 (is_implicated_in)
Diseasepancreatitis (biomarker_via_orthology)

FGB CTSV

1.85e-0339482DOID:4989 (biomarker_via_orthology)
Diseasebreast cancer (is_implicated_in)

UBR5 F5 SULT1E1

1.88e-03150483DOID:1612 (is_implicated_in)
DiseaseMoyamoya disease

FBXO25 LRP1

1.94e-0340482MONDO_0016820
Diseaseend stage renal disease (is_implicated_in)

FGB F5

2.04e-0341482DOID:783 (is_implicated_in)
Diseaseglioblastoma (is_marker_for)

CBX6 CBX8

2.35e-0344482DOID:3068 (is_marker_for)
Diseaseage at menarche

B3GALNT1 COLEC12 MYO6 CBX6 USP35

2.73e-03594485EFO_0004703
Diseasehepatocellular carcinoma (implicated_via_orthology)

POLG CTSV

2.90e-0349482DOID:684 (implicated_via_orthology)
DiseaseProstatic Neoplasms

SETDB1 BNIP3 PRKDC EMP3 SULT1E1

3.19e-03616485C0033578
DiseaseMalignant neoplasm of prostate

SETDB1 BNIP3 PRKDC EMP3 SULT1E1

3.19e-03616485C0376358

Protein segments in the cluster

PeptideGeneStartEntry
NWEEGDDPWKEHAKW

NAIP

206

Q13075
VKVWSDWMLGYPDTW

SMG6

1026

Q86US8
KWKGWAIKYSTWEPE

CBX6

31

O95503
FWDPIGRYKWDAWNS

ACBD4

61

Q8NC06
YWLVKNSWGPEWGSN

CTSV

296

O60911
WDPIGRYKWDAWSSL

ACBD5

91

Q5T8D3
PGDQWSLGFSYSWWK

CCDC144NL

41

Q6NUI1
DWANDFGKPWWQGSY

CYB5D1

111

Q6P9G0
DWDDKDWDYGKWRSS

CLK1

11

P49759
LGPEDWKPQTWDYGW

GSG1L2

191

A8MUP6
WQYPPESKWWKTLRE

HACL1

341

Q9UJ83
VSGDERDKGWWWENA

NAAA

191

Q02083
DPLNGWMYWTDWEED

LRP1

656

Q07954
WMYWTDWEEDPKDSR

LRP1

661

Q07954
AIRVTWGEKKSWWGY

B3GALNT1

96

O75752
WGEKKSWWGYEVLTF

B3GALNT1

101

O75752
TDDGVVWMNWKGSWY

FGB

461

P02675
EWKWLDGTSPDYKNW

COLEC12

676

Q5KU26
GERYKEDPWLWDLEW

POLG

476

P54098
LGWWLFTSWKEKNQD

PGM2

351

Q96G03
QDWRSPGWSWIKTED

FBXO25

6

Q8TCJ0
SEWFWWYWQKEKIPK

FUCA2

71

Q9BTY2
KKNSDWIWDWSSRPE

BNIP3

111

Q12983
KWKGWSQKYSTWEPE

CBX8

31

Q9HC52
TWDWFSWLFLPSESK

CD44

241

P16070
PENDSWKEMWLQDYW

FUT11

441

Q495W5
YWILKNSWGAQWGEK

CTSW

326

P56202
KWRGWSPKYNTWEPE

CBX4

31

O00257
KSWWTLPGKESLNLW

EMP3

26

P54852
PTDDKWDWLLAKTWV

ALOX15B

346

O15296
DWHKELYDWRLGPWN

THSD7A

116

Q9UPZ6
SFKKSWWGDYWEPFR

F5

2086

P12259
ELWQRDFWGKESLWG

FER1L5

1151

A0AVI2
EWLSLKTYKWQGLWN

PTDSS2

266

Q9BVG9
GQLIKTEWEGTWWKS

SETDB1

351

Q15047
FWGKAAEQISWYKPW

ACSS3

76

Q9H6R3
WQAEEKWDEPWYNQK

ATP11B

311

Q9Y2G3
NKDWWWGRSEDKEAW

SPATA13

181

Q96N96
WSKLWESPDHLGYWT

TICRR

216

Q7Z2Z1
VKDPEDNKGWFSWLW

VPS13A

421

Q96RL7
FQNSREWSGKEKWWD

PBXIP1

466

Q96AQ6
WYKHVKSWWEKGKSP

SULT1E1

171

P49888
IDWVSWPLGKNIDKW

USP35

271

Q9P2H5
TLPLWIDYTWNKDNW

GPR65

66

Q8IYL9
EKCGWYWGPMNWEDA

SOCS7

396

O14512
WKKCDSWWAKDSPLE

PRKDC

1626

P78527
IERTPSWQDWKKAWD

WDR87

1451

Q6ZQQ6
QKWKWWEEERYPEGI

TOP1

201

P11387
SKGELYQWKWSESEP

UBR5

386

O95071
TWKKNYSLWPWGSCD

TMEM260

531

Q9NX78
SKKKGWWYAHFDGPW

MYO6

1196

Q9UM54