| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | I-SMAD binding | 9.59e-07 | 17 | 92 | 4 | GO:0070411 | |
| GeneOntologyMolecularFunction | ubiquitin protein ligase binding | 1.65e-04 | 337 | 92 | 8 | GO:0031625 | |
| GeneOntologyMolecularFunction | R-SMAD binding | 2.28e-04 | 26 | 92 | 3 | GO:0070412 | |
| GeneOntologyMolecularFunction | ubiquitin-like protein ligase binding | 2.48e-04 | 358 | 92 | 8 | GO:0044389 | |
| GeneOntologyMolecularFunction | aldo-keto reductase (NADPH) activity | 4.26e-04 | 32 | 92 | 3 | GO:0004033 | |
| GeneOntologyMolecularFunction | SMAD binding | 6.72e-04 | 86 | 92 | 4 | GO:0046332 | |
| GeneOntologyMolecularFunction | DEAD/H-box RNA helicase binding | 7.40e-04 | 9 | 92 | 2 | GO:0017151 | |
| GeneOntologyMolecularFunction | olfactory receptor activity | 8.45e-04 | 431 | 92 | 8 | GO:0004984 | |
| GeneOntologyCellularComponent | heteromeric SMAD protein complex | 2.32e-08 | 8 | 91 | 4 | GO:0071144 | |
| GeneOntologyCellularComponent | SMAD protein complex | 6.92e-08 | 10 | 91 | 4 | GO:0071141 | |
| GeneOntologyCellularComponent | activin responsive factor complex | 5.61e-05 | 3 | 91 | 2 | GO:0032444 | |
| HumanPheno | Chronic fatigue | 9.87e-06 | 25 | 29 | 4 | HP:0012432 | |
| HumanPheno | Cardiomegaly | 8.20e-05 | 133 | 29 | 6 | HP:0001640 | |
| HumanPheno | Abnormal carotid artery morphology | 1.45e-04 | 92 | 29 | 5 | HP:0005344 | |
| HumanPheno | Mucoid extracellular matrix accumulation | 1.51e-04 | 19 | 29 | 3 | HP:0200146 | |
| HumanPheno | Medial degeneration | 1.51e-04 | 19 | 29 | 3 | HP:0032079 | |
| HumanPheno | Cystic medial necrosis | 1.51e-04 | 19 | 29 | 3 | HP:0012180 | |
| HumanPheno | Descending thoracic aorta aneurysm | 1.51e-04 | 19 | 29 | 3 | HP:0004959 | |
| HumanPheno | Paroxysmal dyspnea | 1.77e-04 | 20 | 29 | 3 | HP:0012763 | |
| HumanPheno | Descending aortic dissection | 2.06e-04 | 21 | 29 | 3 | HP:0012499 | |
| HumanPheno | Hypokinesia | 2.20e-04 | 54 | 29 | 4 | HP:0002375 | |
| HumanPheno | Juvenile gastrointestinal polyposis | 3.10e-04 | 5 | 29 | 2 | HP:0004784 | |
| HumanPheno | Duodenal polyposis | 3.10e-04 | 5 | 29 | 2 | HP:0004783 | |
| HumanPheno | Small intestinal polyposis | 3.10e-04 | 5 | 29 | 2 | HP:0030256 | |
| HumanPheno | Dural ectasia | 3.10e-04 | 24 | 29 | 3 | HP:0100775 | |
| HumanPheno | Carotid artery dilatation | 3.10e-04 | 24 | 29 | 3 | HP:0012163 | |
| HumanPheno | Abnormal spinal meningeal morphology | 3.51e-04 | 25 | 29 | 3 | HP:0010303 | |
| MousePheno | abnormal visceral endoderm morphology | 1.55e-05 | 66 | 67 | 5 | MP:0011186 | |
| MousePheno | abnormal embryonic-extraembryonic boundary morphology | 2.01e-05 | 34 | 67 | 4 | MP:0003890 | |
| Domain | Dwarfin | 3.32e-08 | 8 | 89 | 4 | IPR013790 | |
| Domain | DWB | 3.32e-08 | 8 | 89 | 4 | SM00524 | |
| Domain | MH2 | 3.32e-08 | 8 | 89 | 4 | PS51076 | |
| Domain | MH1 | 3.32e-08 | 8 | 89 | 4 | PS51075 | |
| Domain | - | 3.32e-08 | 8 | 89 | 4 | 3.90.520.10 | |
| Domain | MAD_homology_MH1 | 3.32e-08 | 8 | 89 | 4 | IPR013019 | |
| Domain | MH2 | 3.32e-08 | 8 | 89 | 4 | PF03166 | |
| Domain | SMAD_dom_Dwarfin-type | 3.32e-08 | 8 | 89 | 4 | IPR001132 | |
| Domain | MAD_homology1_Dwarfin-type | 2.32e-07 | 12 | 89 | 4 | IPR003619 | |
| Domain | DWA | 2.32e-07 | 12 | 89 | 4 | SM00523 | |
| Domain | MH1 | 2.32e-07 | 12 | 89 | 4 | PF03165 | |
| Domain | SMAD_dom-like | 8.39e-07 | 16 | 89 | 4 | IPR017855 | |
| Domain | - | 8.39e-07 | 16 | 89 | 4 | 2.60.200.10 | |
| Domain | - | 5.60e-05 | 16 | 89 | 3 | 3.20.20.100 | |
| Domain | zf-RNPHF | 6.72e-05 | 3 | 89 | 2 | PF08080 | |
| Domain | Znf_CHHC | 6.72e-05 | 3 | 89 | 2 | IPR012996 | |
| Domain | NADP_OxRdtase_dom | 6.78e-05 | 17 | 89 | 3 | IPR023210 | |
| Domain | Aldo_ket_red | 6.78e-05 | 17 | 89 | 3 | PF00248 | |
| Domain | Aldo/ket_red/Kv-b | 6.78e-05 | 17 | 89 | 3 | IPR001395 | |
| Domain | Olfact_rcpt | 1.06e-04 | 393 | 89 | 9 | IPR000725 | |
| Domain | SMAD_FHA_domain | 1.10e-04 | 52 | 89 | 4 | IPR008984 | |
| Domain | Hr1 | 4.64e-04 | 7 | 89 | 2 | SM00742 | |
| Domain | HR1 | 6.17e-04 | 8 | 89 | 2 | PF02185 | |
| Domain | ALDOKETO_REDUCTASE_1 | 9.86e-04 | 10 | 89 | 2 | PS00798 | |
| Domain | Aldo/ket_reductase_CS | 9.86e-04 | 10 | 89 | 2 | IPR018170 | |
| Domain | Aldo/keto_reductase | 9.86e-04 | 10 | 89 | 2 | IPR020471 | |
| Domain | ALDOKETO_REDUCTASE_2 | 9.86e-04 | 10 | 89 | 2 | PS00062 | |
| Domain | ALDOKETO_REDUCTASE_3 | 9.86e-04 | 10 | 89 | 2 | PS00063 | |
| Domain | 7tm_1 | OR10A3 OR5M9 OR9K2 OR4S2 GPR182 OR4E2 OR2D3 OR4B1 OR14C36 OR3A4P | 1.41e-03 | 677 | 89 | 10 | PF00001 |
| Domain | G_PROTEIN_RECEP_F1_1 | OR10A3 OR5M9 OR9K2 OR4S2 GPR182 OR4E2 OR2D3 OR4B1 OR14C36 OR3A4P | 1.54e-03 | 685 | 89 | 10 | PS00237 |
| Domain | G_PROTEIN_RECEP_F1_2 | OR10A3 OR5M9 OR9K2 OR4S2 GPR182 OR4E2 OR2D3 OR4B1 OR14C36 OR3A4P | 1.65e-03 | 691 | 89 | 10 | PS50262 |
| Domain | GPCR_Rhodpsn | OR10A3 OR5M9 OR9K2 OR4S2 GPR182 OR4E2 OR2D3 OR4B1 OR14C36 OR3A4P | 1.66e-03 | 692 | 89 | 10 | IPR000276 |
| Domain | PIN_domain-like | 1.97e-03 | 14 | 89 | 2 | IPR029060 | |
| Domain | BRCT | 3.64e-03 | 19 | 89 | 2 | PF00533 | |
| Domain | GPCR_Rhodpsn_7TM | 4.61e-03 | 670 | 89 | 9 | IPR017452 | |
| Domain | BRCT | 4.87e-03 | 22 | 89 | 2 | SM00292 | |
| Domain | - | 5.32e-03 | 23 | 89 | 2 | 3.40.50.10190 | |
| Domain | SH3_9 | 6.15e-03 | 78 | 89 | 3 | PF14604 | |
| Domain | HR1_rho-bd | 6.27e-03 | 25 | 89 | 2 | IPR011072 | |
| Domain | BRCT | 6.77e-03 | 26 | 89 | 2 | PS50172 | |
| Domain | BRCT_dom | 7.83e-03 | 28 | 89 | 2 | IPR001357 | |
| Pathway | BIOCARTA_TGFB_PATHWAY | 1.42e-06 | 17 | 72 | 4 | MM1509 | |
| Pathway | BIOCARTA_TGFB_PATHWAY | 2.29e-06 | 19 | 72 | 4 | M18933 | |
| Pathway | REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION | 2.53e-06 | 6 | 72 | 3 | MM15534 | |
| Pathway | REACTOME_SIGNALING_BY_NODAL | 2.53e-06 | 6 | 72 | 3 | MM14517 | |
| Pathway | REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION | 4.41e-06 | 7 | 72 | 3 | M27807 | |
| Pathway | REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER | 4.41e-06 | 7 | 72 | 3 | M29623 | |
| Pathway | REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES | 4.41e-06 | 7 | 72 | 3 | MM15661 | |
| Pathway | KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY | 7.02e-06 | 8 | 72 | 3 | M47415 | |
| Pathway | KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY | 7.02e-06 | 8 | 72 | 3 | M47849 | |
| Pathway | KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY | 7.02e-06 | 8 | 72 | 3 | M47846 | |
| Pathway | REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER | 7.02e-06 | 8 | 72 | 3 | M27246 | |
| Pathway | WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS | 1.35e-05 | 29 | 72 | 4 | M39516 | |
| Pathway | KEGG_COLORECTAL_CANCER | 1.56e-05 | 62 | 72 | 5 | M14631 | |
| Pathway | WP_TGFB_SMAD_SIGNALING | 2.72e-05 | 12 | 72 | 3 | M48091 | |
| Pathway | WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER | 3.46e-05 | 73 | 72 | 5 | M39758 | |
| Pathway | REACTOME_SIGNALING_BY_ACTIVIN | 5.56e-05 | 15 | 72 | 3 | MM14593 | |
| Pathway | PID_SMAD2_3PATHWAY | 6.82e-05 | 16 | 72 | 3 | M228 | |
| Pathway | REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM | 8.25e-05 | 17 | 72 | 3 | M48030 | |
| Pathway | REACTOME_SIGNALING_BY_ACTIVIN | 8.25e-05 | 17 | 72 | 3 | M26965 | |
| Pathway | REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION | 8.25e-05 | 17 | 72 | 3 | M45017 | |
| Pathway | WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING | 8.25e-05 | 17 | 72 | 3 | M39686 | |
| Pathway | REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES | 8.25e-05 | 17 | 72 | 3 | M27946 | |
| Pathway | WP_ENDODERM_DIFFERENTIATION | 8.84e-05 | 143 | 72 | 6 | M39591 | |
| Pathway | WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION | 1.17e-04 | 19 | 72 | 3 | M39370 | |
| Pathway | WP_TGFBETA_SIGNALING_PATHWAY | 1.52e-04 | 53 | 72 | 4 | MM15880 | |
| Pathway | WP_TGFBETA_RECEPTOR_SIGNALING | 1.75e-04 | 55 | 72 | 4 | M39351 | |
| Pathway | WP_PROGERIAASSOCIATED_LIPODYSTROPHY | 1.83e-04 | 22 | 72 | 3 | M42534 | |
| Pathway | REACTOME_FOXO_MEDIATED_TRANSCRIPTION | 1.83e-04 | 22 | 72 | 3 | MM15656 | |
| Pathway | REACTOME_SIGNALING_BY_NODAL | 2.10e-04 | 23 | 72 | 3 | M511 | |
| Pathway | WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS | 2.30e-04 | 59 | 72 | 4 | M39886 | |
| Pathway | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | 2.39e-04 | 24 | 72 | 3 | MM14877 | |
| Pathway | REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION | 2.55e-04 | 5 | 72 | 2 | M27825 | |
| Pathway | WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE | 2.71e-04 | 25 | 72 | 3 | M39713 | |
| Pathway | PID_MYC_REPRESS_PATHWAY | 2.97e-04 | 63 | 72 | 4 | M254 | |
| Pathway | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | 3.05e-04 | 26 | 72 | 3 | MM14878 | |
| Pathway | REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES | 4.70e-04 | 30 | 72 | 3 | M27941 | |
| Pathway | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | 5.18e-04 | 31 | 72 | 3 | M669 | |
| Pathway | KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY | 5.31e-04 | 7 | 72 | 2 | M47845 | |
| Pathway | KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS | 6.26e-04 | 135 | 72 | 5 | M15247 | |
| Pathway | KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY | 7.06e-04 | 8 | 72 | 2 | M47847 | |
| Pathway | KEGG_OLFACTORY_TRANSDUCTION | 8.01e-04 | 389 | 72 | 8 | M14091 | |
| Pathway | WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING | 8.08e-04 | 36 | 72 | 3 | M39569 | |
| Pathway | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | 8.08e-04 | 36 | 72 | 3 | M633 | |
| Pathway | WP_NEOVASCULARIZATION_PROCESSES | 8.76e-04 | 37 | 72 | 3 | M39506 | |
| Pathway | BIOCARTA_ALK_PATHWAY | 8.76e-04 | 37 | 72 | 3 | M17400 | |
| Pathway | WP_BENZOAPYRENE_METABOLISM | 9.05e-04 | 9 | 72 | 2 | M39344 | |
| Pathway | KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY | 9.05e-04 | 9 | 72 | 2 | M47844 | |
| Pathway | KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY | 9.05e-04 | 9 | 72 | 2 | M47822 | |
| Pathway | KEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY | 9.05e-04 | 9 | 72 | 2 | M47817 | |
| Pathway | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS | 9.48e-04 | 38 | 72 | 3 | MM14874 | |
| Pathway | KEGG_TGF_BETA_SIGNALING_PATHWAY | 9.69e-04 | 86 | 72 | 4 | M2642 | |
| Pathway | KEGG_WNT_SIGNALING_PATHWAY | 1.04e-03 | 151 | 72 | 5 | M19428 | |
| Pathway | WP_CANCER_PATHWAYS | 1.06e-03 | 507 | 72 | 9 | M48302 | |
| Pathway | WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA | 1.10e-03 | 40 | 72 | 3 | M48337 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER | 1.18e-03 | 41 | 72 | 3 | MM14876 | |
| Pathway | REACTOME_OLFACTORY_SIGNALING_PATHWAY | 1.25e-03 | 417 | 72 | 8 | M4072 | |
| Pathway | KEGG_PATHWAYS_IN_CANCER | 1.32e-03 | 325 | 72 | 7 | M12868 | |
| Pathway | PID_ALK2_PATHWAY | 1.37e-03 | 11 | 72 | 2 | M203 | |
| Pathway | KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY | 1.37e-03 | 11 | 72 | 2 | M47848 | |
| Pathway | KEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM | 1.37e-03 | 11 | 72 | 2 | M47812 | |
| Pathway | REACTOME_SENSORY_PERCEPTION | OR10A3 OR5M9 OR9K2 OR4S2 OTOGL OR4E2 AKR1C3 OR2D3 OR4B1 OR14C36 | 1.39e-03 | 636 | 72 | 10 | M41834 |
| Pathway | WP_MIR127_IN_MESENDODERM_DIFFERENTIATION | 1.64e-03 | 12 | 72 | 2 | MM15910 | |
| Pathway | WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY | 1.66e-03 | 46 | 72 | 3 | M39828 | |
| Pathway | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS | 1.76e-03 | 47 | 72 | 3 | M646 | |
| Pathway | WP_INTEGRATED_CANCER_PATHWAY | 1.87e-03 | 48 | 72 | 3 | M39628 | |
| Pathway | WP_ID_SIGNALING_PATHWAY | 2.11e-03 | 50 | 72 | 3 | MM15817 | |
| Pathway | REACTOME_DEUBIQUITINATION | 2.18e-03 | 262 | 72 | 6 | MM15286 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER | 2.23e-03 | 51 | 72 | 3 | M665 | |
| Pathway | REACTOME_FORMATION_OF_AXIAL_MESODERM | 2.25e-03 | 14 | 72 | 2 | M46441 | |
| Pathway | WP_WNT_SIGNALING_PATHWAY | 2.40e-03 | 110 | 72 | 4 | MM15977 | |
| Pathway | PID_TGFBR_PATHWAY | 2.63e-03 | 54 | 72 | 3 | M286 | |
| Pathway | WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER | 2.63e-03 | 54 | 72 | 3 | M42568 | |
| Pathway | WP_ESC_PLURIPOTENCY_PATHWAYS | 2.91e-03 | 116 | 72 | 4 | MM15863 | |
| Pathway | WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA | 2.92e-03 | 56 | 72 | 3 | M39413 | |
| Pathway | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | 2.95e-03 | 16 | 72 | 2 | MM14873 | |
| Pathway | REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS | 2.95e-03 | 16 | 72 | 2 | M46428 | |
| Pathway | WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS | 3.00e-03 | 117 | 72 | 4 | M39530 | |
| Pathway | WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES | 3.07e-03 | 57 | 72 | 3 | M39877 | |
| Pathway | REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS | 3.10e-03 | 118 | 72 | 4 | MM15588 | |
| Pathway | WP_CELL_CYCLE | 3.29e-03 | 120 | 72 | 4 | M39650 | |
| Pathway | KEGG_CELL_CYCLE | 3.81e-03 | 125 | 72 | 4 | M7963 | |
| Pathway | BIOCARTA_TOB1_PATHWAY | 4.16e-03 | 19 | 72 | 2 | M18215 | |
| Pathway | WP_HYPOXIADEPENDENT_PROLIFERATION_OF_MYOBLASTS | 4.16e-03 | 19 | 72 | 2 | MM15811 | |
| Pathway | BIOCARTA_TOB1_PATHWAY | 4.16e-03 | 19 | 72 | 2 | MM1490 | |
| Pathway | REACTOME_DEUBIQUITINATION | 4.19e-03 | 299 | 72 | 6 | M27574 | |
| Pathway | WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY | 4.33e-03 | 301 | 72 | 6 | MM15983 | |
| Pathway | WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT | 4.61e-03 | 20 | 72 | 2 | MM15907 | |
| Pathway | KEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY | 4.61e-03 | 20 | 72 | 2 | M47843 | |
| Pathway | WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT | 4.61e-03 | 20 | 72 | 2 | M39624 | |
| Pathway | REACTOME_FOXO_MEDIATED_TRANSCRIPTION | 4.64e-03 | 66 | 72 | 3 | M27938 | |
| Pubmed | Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. | 4.79e-11 | 4 | 93 | 4 | 10708952 | |
| Pubmed | TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. | 2.39e-10 | 5 | 93 | 4 | 15735739 | |
| Pubmed | 7.16e-10 | 6 | 93 | 4 | 10400677 | ||
| Pubmed | 7.16e-10 | 6 | 93 | 4 | 11169847 | ||
| Pubmed | 7.16e-10 | 6 | 93 | 4 | 11850197 | ||
| Pubmed | Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. | 1.67e-09 | 7 | 93 | 4 | 14699069 | |
| Pubmed | 1.67e-09 | 7 | 93 | 4 | 10376010 | ||
| Pubmed | Negative regulation of BMP/Smad signaling by Tob in osteoblasts. | 1.67e-09 | 7 | 93 | 4 | 11163184 | |
| Pubmed | 1.67e-09 | 7 | 93 | 4 | 12370310 | ||
| Pubmed | A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. | 3.33e-09 | 8 | 93 | 4 | 19211612 | |
| Pubmed | 3.33e-09 | 8 | 93 | 4 | 10647776 | ||
| Pubmed | 3.33e-09 | 8 | 93 | 4 | 10531362 | ||
| Pubmed | 3.33e-09 | 8 | 93 | 4 | 10708949 | ||
| Pubmed | 5.97e-09 | 9 | 93 | 4 | 9759503 | ||
| Pubmed | 5.97e-09 | 9 | 93 | 4 | 10708948 | ||
| Pubmed | TGF-β signaling inhibits canonical BMP signaling pathway during palate development. | 9.94e-09 | 10 | 93 | 4 | 29247325 | |
| Pubmed | 9.94e-09 | 10 | 93 | 4 | 23620745 | ||
| Pubmed | Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. | 9.94e-09 | 10 | 93 | 4 | 12543979 | |
| Pubmed | 1.56e-08 | 11 | 93 | 4 | 24008158 | ||
| Pubmed | 1.85e-08 | 3 | 93 | 3 | 15166010 | ||
| Pubmed | 1.85e-08 | 3 | 93 | 3 | 16322555 | ||
| Pubmed | TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines. | 1.85e-08 | 3 | 93 | 3 | 12618756 | |
| Pubmed | 1.85e-08 | 3 | 93 | 3 | 35359452 | ||
| Pubmed | Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. | 1.85e-08 | 3 | 93 | 3 | 31582430 | |
| Pubmed | Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. | 1.85e-08 | 3 | 93 | 3 | 12191474 | |
| Pubmed | 1.85e-08 | 3 | 93 | 3 | 23139211 | ||
| Pubmed | 1.85e-08 | 3 | 93 | 3 | 29924446 | ||
| Pubmed | Structural basis of heteromeric smad protein assembly in TGF-beta signaling. | 1.85e-08 | 3 | 93 | 3 | 15350224 | |
| Pubmed | 2.33e-08 | 12 | 93 | 4 | 14656760 | ||
| Pubmed | Endoglin is required for myogenic differentiation potential of neural crest stem cells. | 3.36e-08 | 13 | 93 | 4 | 17628518 | |
| Pubmed | Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture. | 4.70e-08 | 14 | 93 | 4 | 33248111 | |
| Pubmed | 4.70e-08 | 14 | 93 | 4 | 25274628 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 9111321 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 19247629 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 14612439 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 32371398 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 9702197 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 17142805 | ||
| Pubmed | Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4. | 7.39e-08 | 4 | 93 | 3 | 14555988 | |
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 18024957 | ||
| Pubmed | Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. | 7.39e-08 | 4 | 93 | 3 | 16007227 | |
| Pubmed | Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. | 7.39e-08 | 4 | 93 | 3 | 17591701 | |
| Pubmed | Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter. | 7.39e-08 | 4 | 93 | 3 | 10823886 | |
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 14502566 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 11114293 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 22418736 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 21095583 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 22442258 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 10878024 | ||
| Pubmed | Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. | 7.39e-08 | 4 | 93 | 3 | 21724602 | |
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 19420158 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 19768112 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 17053951 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 12419246 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 12097320 | ||
| Pubmed | Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis. | 7.39e-08 | 4 | 93 | 3 | 31591477 | |
| Pubmed | Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-cadherin. | 7.39e-08 | 4 | 93 | 3 | 25105734 | |
| Pubmed | TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. | 7.39e-08 | 4 | 93 | 3 | 12531695 | |
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 30653987 | ||
| Pubmed | 7.39e-08 | 4 | 93 | 3 | 28240243 | ||
| Pubmed | Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. | 7.39e-08 | 4 | 93 | 3 | 10549282 | |
| Pubmed | Differential ubiquitination defines the functional status of the tumor suppressor Smad4. | 7.39e-08 | 4 | 93 | 3 | 12794086 | |
| Pubmed | Nuclear targeting of transforming growth factor-beta-activated Smad complexes. | 7.39e-08 | 4 | 93 | 3 | 15799969 | |
| Pubmed | Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. | 1.11e-07 | 17 | 93 | 4 | 27398409 | |
| Pubmed | 1.42e-07 | 18 | 93 | 4 | 23546880 | ||
| Pubmed | Cellular response to hypoxia involves signaling via Smad proteins. | 1.84e-07 | 5 | 93 | 3 | 12411310 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 35811497 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 15647271 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 12808092 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 27383203 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 17283070 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 11231077 | ||
| Pubmed | Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. | 1.84e-07 | 5 | 93 | 3 | 12917407 | |
| Pubmed | TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. | 1.84e-07 | 5 | 93 | 3 | 9679056 | |
| Pubmed | FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct. | 1.84e-07 | 5 | 93 | 3 | 27164167 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 14729983 | ||
| Pubmed | Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture. | 1.84e-07 | 5 | 93 | 3 | 25207745 | |
| Pubmed | USP15 is a deubiquitylating enzyme for receptor-activated SMADs. | 1.84e-07 | 5 | 93 | 3 | 21947082 | |
| Pubmed | Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. | 1.84e-07 | 5 | 93 | 3 | 17429065 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 15467747 | ||
| Pubmed | The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. | 1.84e-07 | 5 | 93 | 3 | 17251190 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 14764653 | ||
| Pubmed | Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. | 1.84e-07 | 5 | 93 | 3 | 10531062 | |
| Pubmed | Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. | 1.84e-07 | 5 | 93 | 3 | 15150278 | |
| Pubmed | Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. | 1.84e-07 | 5 | 93 | 3 | 18184786 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 22045334 | ||
| Pubmed | Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. | 1.84e-07 | 5 | 93 | 3 | 17591695 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 18566469 | ||
| Pubmed | Carboxy-terminally truncated Gli3 proteins associate with Smads. | 1.84e-07 | 5 | 93 | 3 | 9843199 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 12672795 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 12732634 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 19819941 | ||
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 25141865 | ||
| Pubmed | A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis. | 1.84e-07 | 5 | 93 | 3 | 36213818 | |
| Pubmed | Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. | 1.84e-07 | 5 | 93 | 3 | 16362038 | |
| Pubmed | TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling. | 1.84e-07 | 5 | 93 | 3 | 23788427 | |
| Pubmed | Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. | 1.84e-07 | 5 | 93 | 3 | 17099224 | |
| Pubmed | 1.84e-07 | 5 | 93 | 3 | 11387330 | ||
| Pubmed | TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. | 1.84e-07 | 5 | 93 | 3 | 18568018 | |
| Pubmed | Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. | 1.84e-07 | 5 | 93 | 3 | 9732876 | |
| Interaction | FOXO3 interactions | 6.37e-08 | 124 | 87 | 8 | int:FOXO3 | |
| Interaction | WWP1 interactions | TRAF4 FAM120A PRKN DDB1 CLUH HNRNPH1 SMAD2 SMAD3 SMAD4 SMAD5 | 1.80e-07 | 260 | 87 | 10 | int:WWP1 |
| Interaction | COL3A1 interactions | 6.85e-07 | 39 | 87 | 5 | int:COL3A1 | |
| Interaction | FHL2 interactions | TRAF4 BRCA1 SREBF2 APC E2F7 PRKN EMSY SMAD2 SMAD3 SMAD4 REV1 | 1.08e-06 | 396 | 87 | 11 | int:FHL2 |
| Interaction | CSNK1D interactions | 1.52e-06 | 254 | 87 | 9 | int:CSNK1D | |
| Interaction | OGFR interactions | 1.97e-06 | 48 | 87 | 5 | int:OGFR | |
| Interaction | MAU2 interactions | 2.03e-06 | 136 | 87 | 7 | int:MAU2 | |
| Interaction | PRPF39 interactions | 2.68e-06 | 51 | 87 | 5 | int:PRPF39 | |
| Interaction | PSMD11 interactions | BRCA1 UBE2Q1 DLD PRKN HNRNPF HNRNPH1 SMAD2 SMAD3 SMAD4 SMAD5 | 2.90e-06 | 353 | 87 | 10 | int:PSMD11 |
| Interaction | RNMT interactions | 3.47e-06 | 95 | 87 | 6 | int:RNMT | |
| Interaction | SMURF1 interactions | TRAF4 RHPN2 COPB2 SREBF2 E2F7 PRKN HNRNPF HNRNPH1 SMAD2 SMAD3 SMAD4 SMAD5 | 3.73e-06 | 544 | 87 | 12 | int:SMURF1 |
| Interaction | TMEM184A interactions | 4.96e-06 | 101 | 87 | 6 | int:TMEM184A | |
| Interaction | ZNF326 interactions | 5.65e-06 | 224 | 87 | 8 | int:ZNF326 | |
| Interaction | HNRNPH2 interactions | 8.10e-06 | 312 | 87 | 9 | int:HNRNPH2 | |
| Interaction | PIAS4 interactions | 9.98e-06 | 173 | 87 | 7 | int:PIAS4 | |
| Interaction | ZNF8 interactions | 1.30e-05 | 70 | 87 | 5 | int:ZNF8 | |
| Interaction | NUP214 interactions | 2.17e-05 | 195 | 87 | 7 | int:NUP214 | |
| Interaction | STRAP interactions | 2.19e-05 | 270 | 87 | 8 | int:STRAP | |
| Interaction | KPNB1 interactions | CAND1 BRCA1 SREBF2 TMEM209 DLD PRKN HNRNPH1 SOAT1 SMAD2 SMAD3 SMAD4 | 2.20e-05 | 544 | 87 | 11 | int:KPNB1 |
| Interaction | CSH2 interactions | 3.41e-05 | 15 | 87 | 3 | int:CSH2 | |
| Interaction | CDK9 interactions | BRCA1 COPB2 NGEF APC AKR1C3 DLD PRKN DDB1 HNRNPH1 SMAD2 SMAD3 SMAD4 | 3.72e-05 | 685 | 87 | 12 | int:CDK9 |
| Interaction | TOB1 interactions | 3.85e-05 | 44 | 87 | 4 | int:TOB1 | |
| Interaction | ACO1 interactions | 4.60e-05 | 46 | 87 | 4 | int:ACO1 | |
| Interaction | PRAME interactions | 5.15e-05 | 93 | 87 | 5 | int:PRAME | |
| Interaction | PTCHD1 interactions | 5.51e-05 | 3 | 87 | 2 | int:PTCHD1 | |
| Interaction | PIAS3 interactions | 5.70e-05 | 95 | 87 | 5 | int:PIAS3 | |
| Interaction | CSH1 interactions | 6.05e-05 | 18 | 87 | 3 | int:CSH1 | |
| Interaction | RHEBL1 interactions | 6.05e-05 | 18 | 87 | 3 | int:RHEBL1 | |
| Interaction | LMO4 interactions | 6.54e-05 | 159 | 87 | 6 | int:LMO4 | |
| Interaction | BUB3 interactions | 6.54e-05 | 232 | 87 | 7 | int:BUB3 | |
| Interaction | BRCA1 interactions | SETX CAND1 MDN1 FAM120A BRCA1 COPB2 PDS5A PRKN DDB1 HNRNPF EMSY HNRNPH1 SMAD2 SMAD3 SMAD4 REV1 | 7.81e-05 | 1249 | 87 | 16 | int:BRCA1 |
| Interaction | TGFB1I1 interactions | 8.07e-05 | 53 | 87 | 4 | int:TGFB1I1 | |
| Interaction | APOBEC1 interactions | 8.40e-05 | 20 | 87 | 3 | int:APOBEC1 | |
| Interaction | RASL12 interactions | 8.40e-05 | 20 | 87 | 3 | int:RASL12 | |
| Interaction | USP9X interactions | 8.62e-05 | 422 | 87 | 9 | int:USP9X | |
| Interaction | UBAP2 interactions | 9.47e-05 | 170 | 87 | 6 | int:UBAP2 | |
| Interaction | NOTCH4 interactions | 9.77e-05 | 21 | 87 | 3 | int:NOTCH4 | |
| Interaction | STIP1 interactions | CAND1 MAPK15 MDN1 BRCA1 COPB2 DLD PDS5A APPL1 PRKN NEB DDB1 HNRNPF HNRNPH1 TNS3 | 9.78e-05 | 1006 | 87 | 14 | int:STIP1 |
| Interaction | UBR5 interactions | 9.92e-05 | 533 | 87 | 10 | int:UBR5 | |
| Interaction | SMAD6 interactions | 1.00e-04 | 56 | 87 | 4 | int:SMAD6 | |
| Interaction | ARHGEF39 interactions | 1.00e-04 | 56 | 87 | 4 | int:ARHGEF39 | |
| Interaction | CEP72 interactions | 1.00e-04 | 107 | 87 | 5 | int:CEP72 | |
| Interaction | HSP90B1 interactions | CAND1 MAPK15 BRCA1 ANPEP MGST3 DLD PRKN ERN2 CLUH HNRNPH1 SOAT1 | 1.09e-04 | 650 | 87 | 11 | int:HSP90B1 |
| Interaction | FOXH1 interactions | 1.10e-04 | 109 | 87 | 5 | int:FOXH1 | |
| Interaction | EYS interactions | 1.10e-04 | 4 | 87 | 2 | int:EYS | |
| Interaction | TTC34 interactions | 1.10e-04 | 4 | 87 | 2 | int:TTC34 | |
| Interaction | DDIT4 interactions | 1.13e-04 | 22 | 87 | 3 | int:DDIT4 | |
| Interaction | TMPRSS12 interactions | 1.29e-04 | 23 | 87 | 3 | int:TMPRSS12 | |
| Interaction | USP7 interactions | FZD6 TRAF4 MDN1 BRCA1 GJB4 ZGRF1 NGEF SREBF2 APC PRKN NEB HNRNPF HNRNPH1 SMAD2 SMAD3 SMAD4 | 1.40e-04 | 1313 | 87 | 16 | int:USP7 |
| Interaction | DZIP3 interactions | 1.42e-04 | 183 | 87 | 6 | int:DZIP3 | |
| Interaction | EID2 interactions | 1.47e-04 | 24 | 87 | 3 | int:EID2 | |
| Interaction | ZNF510 interactions | 1.47e-04 | 24 | 87 | 3 | int:ZNF510 | |
| Interaction | SMURF2 interactions | 1.50e-04 | 185 | 87 | 6 | int:SMURF2 | |
| Interaction | MECOM interactions | 1.58e-04 | 358 | 87 | 8 | int:MECOM | |
| Interaction | RASD2 interactions | 1.67e-04 | 25 | 87 | 3 | int:RASD2 | |
| Interaction | DMKN interactions | 1.67e-04 | 25 | 87 | 3 | int:DMKN | |
| Interaction | ZMYM2 interactions | 1.72e-04 | 271 | 87 | 7 | int:ZMYM2 | |
| Interaction | ITGBL1 interactions | 1.83e-04 | 5 | 87 | 2 | int:ITGBL1 | |
| Interaction | AKAP8 interactions | 1.89e-04 | 193 | 87 | 6 | int:AKAP8 | |
| Interaction | NME1 interactions | 1.89e-04 | 193 | 87 | 6 | int:NME1 | |
| Interaction | GANAB interactions | 1.91e-04 | 368 | 87 | 8 | int:GANAB | |
| Interaction | ANAPC10 interactions | 2.14e-04 | 68 | 87 | 4 | int:ANAPC10 | |
| Interaction | NEK2 interactions | 2.24e-04 | 127 | 87 | 5 | int:NEK2 | |
| Interaction | ETV4 interactions | 2.26e-04 | 69 | 87 | 4 | int:ETV4 | |
| Interaction | LPCAT1 interactions | 2.41e-04 | 129 | 87 | 5 | int:LPCAT1 | |
| Interaction | SMARCC1 interactions | 2.54e-04 | 384 | 87 | 8 | int:SMARCC1 | |
| Interaction | NAP1L4 interactions | 2.69e-04 | 206 | 87 | 6 | int:NAP1L4 | |
| Interaction | HK2 interactions | 2.98e-04 | 135 | 87 | 5 | int:HK2 | |
| Interaction | TELO2 interactions | 2.98e-04 | 135 | 87 | 5 | int:TELO2 | |
| Interaction | CCDC180 interactions | 3.20e-04 | 31 | 87 | 3 | int:CCDC180 | |
| Interaction | DFFB interactions | 3.20e-04 | 31 | 87 | 3 | int:DFFB | |
| Interaction | MEF2A interactions | 3.28e-04 | 76 | 87 | 4 | int:MEF2A | |
| Interaction | RBBP7 interactions | 3.39e-04 | 507 | 87 | 9 | int:RBBP7 | |
| Interaction | SUPV3L1 interactions | 3.41e-04 | 139 | 87 | 5 | int:SUPV3L1 | |
| Interaction | CDKN2AIP interactions | 3.52e-04 | 140 | 87 | 5 | int:CDKN2AIP | |
| Interaction | SERPINH1 interactions | 3.60e-04 | 306 | 87 | 7 | int:SERPINH1 | |
| Interaction | SNW1 interactions | CAND1 MDN1 UBE2Q1 ANAPC1 NIBAN2 DDB1 HNRNPF HNRNPH1 SMAD2 SMAD3 SMAD4 | 3.63e-04 | 747 | 87 | 11 | int:SNW1 |
| Interaction | WWOX interactions | CAND1 BRCA1 COPB2 DHRS13 DLD PRKN HNRNPF HNRNPH1 SMAD3 SMAD4 | 3.67e-04 | 627 | 87 | 10 | int:WWOX |
| Interaction | RAB34 interactions | 3.80e-04 | 79 | 87 | 4 | int:RAB34 | |
| Interaction | CDK8 interactions | 4.01e-04 | 222 | 87 | 6 | int:CDK8 | |
| Interaction | EED interactions | FCF1 SETX CAND1 BRCA1 MGST3 RHPN2 COPB2 SREBF2 PDS5A PRKN NIBAN2 DDB1 CLUH HNRNPF HNRNPH1 SOAT1 | 4.13e-04 | 1445 | 87 | 16 | int:EED |
| Interaction | ERCC2 interactions | 4.18e-04 | 81 | 87 | 4 | int:ERCC2 | |
| Interaction | STAG2 interactions | 4.21e-04 | 224 | 87 | 6 | int:STAG2 | |
| Interaction | ALKBH4 interactions | 4.22e-04 | 34 | 87 | 3 | int:ALKBH4 | |
| Interaction | UBE2T interactions | 4.38e-04 | 82 | 87 | 4 | int:UBE2T | |
| Interaction | PKNOX1 interactions | 4.38e-04 | 82 | 87 | 4 | int:PKNOX1 | |
| Interaction | SMU1 interactions | 4.52e-04 | 227 | 87 | 6 | int:SMU1 | |
| Interaction | REV1 interactions | 4.60e-04 | 35 | 87 | 3 | int:REV1 | |
| Interaction | YARS1 interactions | 4.69e-04 | 149 | 87 | 5 | int:YARS1 | |
| Interaction | FLNA interactions | 4.75e-04 | 648 | 87 | 10 | int:FLNA | |
| Interaction | BTRC interactions | CAND1 MDN1 FAM120A APC DLD PRKN DDB1 HNRNPF HNRNPH1 SMAD3 SMAD4 | 4.95e-04 | 775 | 87 | 11 | int:BTRC |
| Interaction | DVL1 interactions | 4.98e-04 | 151 | 87 | 5 | int:DVL1 | |
| Interaction | DNAJC7 interactions | 5.00e-04 | 425 | 87 | 8 | int:DNAJC7 | |
| Interaction | SCUBE3 interactions | 5.07e-04 | 8 | 87 | 2 | int:SCUBE3 | |
| Interaction | HNRNPUL2-BSCL2 interactions | 5.07e-04 | 8 | 87 | 2 | int:HNRNPUL2-BSCL2 | |
| Interaction | TGM2 interactions | 5.42e-04 | 235 | 87 | 6 | int:TGM2 | |
| Interaction | ZCCHC8 interactions | 5.45e-04 | 154 | 87 | 5 | int:ZCCHC8 | |
| Interaction | RANBP9 interactions | 5.65e-04 | 433 | 87 | 8 | int:RANBP9 | |
| Interaction | PBK interactions | 5.78e-04 | 156 | 87 | 5 | int:PBK | |
| Interaction | USP15 interactions | 5.79e-04 | 546 | 87 | 9 | int:USP15 | |
| Cytoband | 19q13.11 | 1.11e-04 | 45 | 94 | 3 | 19q13.11 | |
| Cytoband | 9q34.13 | 8.49e-04 | 21 | 94 | 2 | 9q34.13 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr15q22 | 2.57e-03 | 132 | 94 | 3 | chr15q22 | |
| Cytoband | 18q21.1 | 2.78e-03 | 38 | 94 | 2 | 18q21.1 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr9q34 | 4.56e-03 | 325 | 94 | 4 | chr9q34 | |
| GeneFamily | SMAD family | 1.34e-08 | 8 | 69 | 4 | 750 | |
| GeneFamily | Aldo-keto reductases | 2.34e-05 | 15 | 69 | 3 | 399 | |
| GeneFamily | UPF1 like RNA helicases | 7.72e-04 | 11 | 69 | 2 | 1169 | |
| Coexpression | TURJANSKI_MAPK1_AND_MAPK2_TARGETS | 8.71e-06 | 12 | 91 | 3 | M15804 | |
| Disease | Benign tumor of pancreas | 7.94e-06 | 13 | 91 | 3 | C0347284 | |
| Disease | Pancreatic carcinoma | 2.65e-05 | 19 | 91 | 3 | C0235974 | |
| Disease | ovarian cancer (is_implicated_in) | 2.75e-05 | 56 | 91 | 4 | DOID:2394 (is_implicated_in) | |
| Disease | Hereditary Diffuse Gastric Cancer | 3.52e-05 | 293 | 91 | 7 | C1708349 | |
| Disease | Stomach Neoplasms | 3.83e-05 | 297 | 91 | 7 | C0038356 | |
| Disease | Malignant neoplasm of stomach | 4.09e-05 | 300 | 91 | 7 | C0024623 | |
| Disease | Lynch syndrome (is_implicated_in) | 5.48e-05 | 24 | 91 | 3 | DOID:3883 (is_implicated_in) | |
| Disease | lumbar disc degeneration | 8.79e-05 | 28 | 91 | 3 | EFO_0004994 | |
| Disease | mucinous adenocarcinoma (is_marker_for) | 9.35e-05 | 5 | 91 | 2 | DOID:3030 (is_marker_for) | |
| Disease | nasopharyngeal neoplasm | 1.07e-04 | 151 | 91 | 5 | EFO_0004252 | |
| Disease | endometrial cancer (is_marker_for) | 1.73e-04 | 35 | 91 | 3 | DOID:1380 (is_marker_for) | |
| Disease | cervical cancer (is_marker_for) | 1.88e-04 | 36 | 91 | 3 | DOID:4362 (is_marker_for) | |
| Disease | Loeys-Dietz Syndrome | 1.96e-04 | 7 | 91 | 2 | C2697932 | |
| Disease | colon cancer (biomarker_via_orthology) | 2.39e-04 | 39 | 91 | 3 | DOID:219 (biomarker_via_orthology) | |
| Disease | Pancreatic carcinoma, familial | 3.34e-04 | 9 | 91 | 2 | C2931038 | |
| Disease | pancreatic cancer (is_implicated_in) | 4.08e-04 | 112 | 91 | 4 | DOID:1793 (is_implicated_in) | |
| Disease | prostate cancer (is_implicated_in) | 4.81e-04 | 117 | 91 | 4 | DOID:10283 (is_implicated_in) | |
| Disease | Familial thoracic aortic aneurysm and aortic dissection | 5.95e-04 | 53 | 91 | 3 | C4707243 | |
| Disease | endometrial carcinoma (is_implicated_in) | 6.08e-04 | 12 | 91 | 2 | DOID:2871 (is_implicated_in) | |
| Disease | metabolite measurement, body weight gain | 6.08e-04 | 12 | 91 | 2 | EFO_0004566, EFO_0004725 | |
| Disease | juvenile polyposis syndrome (implicated_via_orthology) | 7.18e-04 | 13 | 91 | 2 | DOID:0050787 (implicated_via_orthology) | |
| Disease | unipolar depression, mood disorder | 8.01e-04 | 134 | 91 | 4 | EFO_0003761, EFO_0004247 | |
| Disease | ceramide measurement | 8.19e-04 | 235 | 91 | 5 | EFO_0010222 | |
| Disease | basophil count, eosinophil count | 9.16e-04 | 241 | 91 | 5 | EFO_0004842, EFO_0005090 | |
| Disease | acute graft vs. host disease, donor genotype effect measurement | 9.62e-04 | 15 | 91 | 2 | EFO_0004599, EFO_0007892 | |
| Disease | HSV2 virologic severity measurement | 9.62e-04 | 15 | 91 | 2 | EFO_0009010 | |
| Disease | breast carcinoma (is_marker_for) | 1.13e-03 | 66 | 91 | 3 | DOID:3459 (is_marker_for) | |
| Disease | rhinitis | 1.24e-03 | 17 | 91 | 2 | EFO_0008521 | |
| Disease | asthma, age at onset | 1.34e-03 | 70 | 91 | 3 | EFO_0004847, MONDO_0004979 | |
| Disease | Left Ventricle Remodeling | 1.90e-03 | 21 | 91 | 2 | C0600520 | |
| Disease | Ventricular Remodeling | 1.90e-03 | 21 | 91 | 2 | C0600519 | |
| Disease | Neoplasm of the genitourinary tract | 2.48e-03 | 24 | 91 | 2 | cv:C0042065 | |
| Disease | breast cancer (is_marker_for) | 2.61e-03 | 185 | 91 | 4 | DOID:1612 (is_marker_for) | |
| Disease | breast cancer (implicated_via_orthology) | 2.69e-03 | 25 | 91 | 2 | DOID:1612 (implicated_via_orthology) |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| FRLHLQNCHYQTIPP | 206 | P41238 | |
| PVCNQVECHPYFNRS | 186 | P42330 | |
| YIRCIAVHPTQPFIL | 101 | P35606 | |
| NPIHPNLRSTVYCNA | 786 | P15144 | |
| NVNYFCRVNPLHFPS | 411 | A6NK59 | |
| CRVNPLHFPSALQYT | 416 | A6NK59 | |
| RAHTPYINIYNCEPA | 156 | P11836 | |
| QEPCYHEIITPEQFQ | 901 | Q29RF7 | |
| TFCHLRPGTPYQAQV | 931 | O95153 | |
| AEVCVRNHVQPYIPS | 331 | Q96TA1 | |
| ACFLVYHSVPAPQHL | 1886 | Q9H1A4 | |
| PRVHLYILPCASQQV | 6 | Q8NGE7 | |
| VFERCHATVNPAPFY | 601 | Q6W4X9 | |
| HYAIVTPNIEPCASQ | 36 | Q8NA72 | |
| LNFHPSYNINRPSIC | 121 | Q5BN46 | |
| DRFAAICHPLNYPVI | 121 | P58181 | |
| FCLYHTPVTPQELRD | 2976 | Q9NU22 | |
| VQYQEFPTASRHLPF | 1846 | Q5T1H1 | |
| SYEHVQPCFIIRPAK | 476 | Q6A163 | |
| TQALQHPYVQRFHCP | 296 | Q8TD08 | |
| PCYLTHTNPRVDEIV | 281 | Q9Y2Z2 | |
| PPVCEQAEYHLFQRE | 261 | Q14722 | |
| HPNVLRYFCTERGPQ | 571 | Q76MJ5 | |
| FPLPCVVLYATHQEN | 566 | Q9UKG1 | |
| LCEIPYRVSQNSHPI | 571 | Q99665 | |
| LYVILCNHSPQVFHP | 501 | Q86VP6 | |
| AYIQHQDFCRAPDPA | 636 | Q3V5L5 | |
| HQIAYCNLLPRDQFP | 656 | Q9Y4D7 | |
| YVAVCQPLHYPVIVN | 121 | Q8NHC7 | |
| VINHFYCDLPQPFQL | 176 | P47883 | |
| VVQLPFCGPNEIDHY | 161 | Q8NH73 | |
| CRLVQRYPGHVPNFL | 586 | A6NGR9 | |
| FQDYIEKHCPSAVVP | 6 | Q9NZB2 | |
| YNFFSPLNPVRVHIE | 306 | P31943 | |
| CIQRAHQNTLEVYPP | 56 | O14880 | |
| YIECNRPQPAHRFLF | 376 | O75469 | |
| GQNIINHYFCEPPAL | 186 | Q8NGH3 | |
| HIPVSCYVQRRFPII | 106 | A0A2R8YFL7 | |
| TRALPCPAHVVFRYQ | 466 | Q86WN1 | |
| QCQELDTYLIPQIPH | 1846 | P38398 | |
| LQYCDETVPVTFDPH | 126 | O60353 | |
| EYCVNPLAHPVFSVA | 491 | Q96AV8 | |
| QHRNCSFSIIYPVVI | 201 | P24387 | |
| REVPQHPSCLFFQYN | 46 | Q9Y324 | |
| PNVCYDEFFPVSHVR | 61 | Q9NTQ9 | |
| YNCVPSVIYTHPEVA | 386 | P09622 | |
| RFSCFQEEAPQPHYQ | 266 | Q16610 | |
| IIQAIPQYAIPCHSS | 1256 | Q7Z589 | |
| PIVQHCDNPPFYRFT | 1506 | Q5TBA9 | |
| VYAPEHKVLQFPCRQ | 96 | A4D1Z8 | |
| PTICFVYQDPQGRHV | 176 | Q16531 | |
| YFANCHVEEVPPAAR | 281 | Q6UX07 | |
| RQHQLYHCQRDEYPP | 171 | Q6J272 | |
| IHQELFAPCHIYISP | 681 | Q3ZCN5 | |
| FPEPQARFYVACVVL | 656 | Q6P5Z2 | |
| IIQLPFCGPNVIDHY | 161 | Q8NGF8 | |
| IRVPAPCQYAHKLAF | 826 | Q96J94 | |
| YNFFSPLNPVRVHIE | 306 | P52597 | |
| QHCPLKNPTFLDYVR | 526 | P35610 | |
| QFVHDPQLGYSLPCV | 276 | O60260 | |
| TYRAPFLIPITCHQI | 1066 | Q4G0N8 | |
| QVPRPGFNYTFAHIC | 126 | Q96NR3 | |
| LHCVINPILYNFLSP | 311 | O15218 | |
| TIPFECLQTGYRHVP | 846 | Q9UPR0 | |
| VCVNPYHYERVVSPG | 126 | Q13485 | |
| LLDCPQVQCVHPYVA | 611 | Q8N5V2 | |
| CQSISRPVPVRFHNY | 1726 | Q7Z333 | |
| GAQCVHSPRFPAQYL | 1011 | Q15477 | |
| RHYPVNSVIFCALDP | 1371 | Q68CZ2 | |
| EINHFYCADPPLIQI | 171 | Q8NGP3 | |
| RGNAPVQVHFLDPYC | 531 | Q8IUC4 | |
| VCINPYHYKRVESPV | 121 | Q99717 | |
| ASVRPAVLQVECHPY | 176 | P14550 | |
| PHFGQQECVSPYRSR | 1091 | P25054 | |
| PESYLIRLPHDCFQN | 406 | O75339 | |
| QRHPFERIATPFQVY | 306 | O75153 | |
| NFYHFTRPLIKPQCA | 466 | Q9NR97 | |
| AHQRSHFEPERPYQC | 381 | P98169 | |
| DRYVAICTPLHYPNV | 121 | Q8NGC2 | |
| QLCPNLQAVPYDFHA | 531 | Q9UBZ9 | |
| QDPTHVIRFPLNGYC | 211 | Q96SI1 | |
| CVNPYHYQRVETPVL | 161 | Q15796 | |
| CVNPYHYQRVETPVL | 121 | P84022 | |
| NTDHLCIIPRFYVHP | 166 | Q9Y458 | |
| YCAQRNPADPIAQVH | 786 | Q12772 | |
| VEVPIVSPICRFTYH | 941 | Q9UQG0 | |
| TIQSHQYQCPRLPVA | 206 | Q9BUZ4 | |
| PNRCHPTRISLVFYQ | 1681 | O43151 | |
| QRPVLSFHVDPYVCN | 136 | Q96L94 | |
| ENVFCIYQSAINPPH | 491 | Q96SK2 | |
| VHSIYIVPFQCPKCE | 286 | Q6IQ21 | |
| RQPYQCPICEHIADN | 666 | Q8TCN5 | |
| SAYLPQRQIHIPAVF | 1276 | Q86YA3 | |
| PVRIHCNITESYPAV | 101 | Q7Z7E8 | |
| CAAPVYPQIINTFHI | 186 | Q15911 | |
| YCASPPRFQEHKVQD | 196 | Q8N145 | |
| PYTPQVIHCRYVGDI | 5071 | P20929 |