Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of protein deubiquitination	ZC3H12A TANK	2.47e-05	5	33	2	GO:1903003
MousePheno	abnormal interleukin-6 secretion	TRIM8 IRAK3 ZC3H12A SLFN11 TANK	1.69e-05	186	25	5	MP:0008704
MousePheno	increased interleukin-6 secretion	TRIM8 IRAK3 ZC3H12A TANK	1.91e-05	91	25	4	MP:0008705
MousePheno	increased tumor necrosis factor secretion	TRIM8 IRAK3 ZC3H12A TANK	5.50e-05	119	25	4	MP:0008560
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	9.07e-06	3	33	2	PF04579
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	1.81e-05	4	33	2	PD010562
Domain	Keratin_matx	KRTAP3-3 KRTAP3-2	3.02e-05	5	33	2	IPR007659
Domain	NPIP	NPIPA7 NPIPA2	2.72e-04	14	33	2	IPR009443
Domain	ZINC_FINGER_C2H2_2	ZNF398 TANK ZNF524 ZNF280D ZNF592 ZBTB18	2.12e-03	775	33	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF398 TANK ZNF524 ZNF280D ZNF592 ZBTB18	2.15e-03	777	33	6	PS00028
Domain	Znf_C2H2	ZNF398 TANK ZNF524 ZNF280D ZNF592 ZBTB18	2.57e-03	805	33	6	IPR007087
Domain	zf-C2H2	ZNF398 ZNF524 ZNF280D ZNF592 ZBTB18	6.95e-03	693	33	5	PF00096
Domain	EGF_CA	CRTAC1 LTBP1	1.01e-02	86	33	2	PF07645
Domain	Znf_C2H2-like	ZNF398 ZNF524 ZNF280D ZNF592 ZBTB18	1.22e-02	796	33	5	IPR015880
Domain	EGF_Ca-bd_CS	CRTAC1 LTBP1	1.27e-02	97	33	2	IPR018097
Domain	ZnF_C2H2	ZNF398 ZNF524 ZNF280D ZNF592 ZBTB18	1.30e-02	808	33	5	SM00355
Domain	EGF_CA	CRTAC1 LTBP1	1.32e-02	99	33	2	PS01187
Domain	EGF_CA	CRTAC1 LTBP1	1.96e-02	122	33	2	SM00179
Pubmed	KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant.	CUL3 DRD4	3.30e-06	3	37	2	26717573
Pubmed	BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.	CUL3 DRD4	6.60e-06	4	37	2	18303015
Pubmed	TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.	ZC3H12A TANK	1.10e-05	5	37	2	25861989
Pubmed	Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins.	CUL3 DRD4	1.65e-05	6	37	2	27155323
Pubmed	Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.	UBE2F CUL3	8.53e-05	13	37	2	23201271
Pubmed	The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.	UBE2F CUL3	8.53e-05	13	37	2	29958295
Pubmed	Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.	UBE2F CUL3	2.51e-04	22	37	2	30587576
Pubmed	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.	UBE2F CUL3	2.75e-04	23	37	2	19250909
Pubmed	Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.	KRTAP3-3 KRTAP3-2	3.52e-04	26	37	2	15454262
Pubmed	Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.	CRISPLD2 LTBP1 ZBTB18	4.49e-04	140	37	3	26930384
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52B4 OR10AG1 OR51H1 OR10A5	4.59e-04	340	37	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52B4 OR10AG1 OR51H1 OR10A5	4.59e-04	340	37	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52B4 OR10AG1 OR51H1 OR10A5	4.75e-04	343	37	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52B4 OR10AG1 OR51H1 OR10A5	4.91e-04	346	37	4	14611657
Pubmed	Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.	KRTAP3-3 KRTAP3-2	7.16e-04	37	37	2	11279113
Interaction	TRAF5 interactions	TRIM8 CUL3 TANK ENOX2	1.16e-05	92	31	4	int:TRAF5
Cytoband	17q12-q21	KRTAP3-3 KRTAP3-2	3.09e-04	32	37	2	17q12-q21
Cytoband	11p15.4	OR52B4 OR51H1 OR10A5	5.67e-04	200	37	3	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52B4 DRD4 OR51H1 OR10A5	1.08e-03	564	37	4	chr11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	SLFN11 GPR179	6.47e-03	149	37	2	chr17q12
GeneFamily	Olfactory receptors, family 10	OR10AG1 OR10A5	3.44e-03	66	24	2	157
GeneFamily	Keratin associated proteins	KRTAP3-3 KRTAP3-2	9.12e-03	109	24	2	619
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF398 ZNF524 ZNF592 ZBTB18	1.39e-02	718	24	4	28
Disease	bipolar disorder, anorexia nervosa	MAU2 ZNF592	1.93e-05	6	34	2	MONDO_0004985, MONDO_0005351
Disease	schizophrenia, anorexia nervosa	CUL3 MAU2 ZNF592	2.33e-05	48	34	3	MONDO_0005090, MONDO_0005351
Disease	triacylglycerol 58:8 measurement	LTBP1 MAU2	7.49e-04	35	34	2	EFO_0010442
Disease	hypertrophic cardiomyopathy	P2RX3 ZNF592	5.06e-03	92	34	2	EFO_0000538
Disease	autism spectrum disorder, schizophrenia	TRIM8 CUL3 ZNF592	6.26e-03	327	34	3	EFO_0003756, MONDO_0005090
Disease	Global developmental delay	TRIM8 ZBTB18	1.03e-02	133	34	2	C0557874

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPFPRACPKCNIHFN	ZNF280D	236	Q6N043
CKFHEILCSFPLIPQ	CMTR2	116	Q8IYT2
VCCAVCNKIIPPAPF	C6orf163	11	Q5TEZ5
QKVCLCPFLPAHPLH	DTWD2	76	Q8NBA8
NHFFCDIPPILKLAC	OR10AG1	166	Q8NH19
TCVPVQLHPSSFPKC	FER1L6-AS1	101	Q8NA97
FFPTAPEKPLCLLVH	GPR179	2266	Q6PRD1
IHCKSCTLFPPNPNL	ENOX2	101	Q16206
HFVTKCAFQPPPSCL	FLT3LG	106	P49771
CPPNFTGKLCQIPVH	LTBP1	421	Q14766
CVVFPVPFLIKCLPF	OR51H1	156	Q8NH63
VPFLIKCLPFCHSNV	OR51H1	161	Q8NH63
PPCIHIPLANVCILA	OR52B4	271	Q8NGK2
AQLCPFEKPATHCPR	CRISPLD2	396	Q9H0B8
HIPQPCVPTCFLLNS	KRTAP3-2	56	Q9BYR7
HIPQPCVPTCFLLNS	KRTAP3-3	56	Q9BYR6
KVPPCPRNFSAKLFC	IRAK3	406	Q9Y616
NLKTPPKCVCSLPFH	NPIPA2	346	E9PIF3
PFFVVHITQALCPAC	DRD4	361	P21917
KCNIPPAPRHAFEIF	CUL3	521	Q13618
FPFVCPRDKPVCVNT	CRTAC1	566	Q9NQ79
FFSLQHPPKCIPKRC	FAM172BP	191	A6NC97
LCVHCLQAVFPFKPP	MAU2	46	Q9Y6X3
KTCRFHPDKDPFCPI	P2RX3	201	P56373
NHFFCDSPPVLKLVC	OR10A5	176	Q9H207
NLKTPPECVCSLPFH	NPIPA7	346	E9PJI5
NLKTPPECVCSLPFH	NPIPA8	346	P0DM63
ANLPCTCKVHFPDPN	UBE2F	46	Q969M7
LPCVHFCQPQRPITF	SLFN11	281	Q7Z7L1
HIPRVCEFCQAVFPP	TANK	391	Q92844
SCPVPCAHFLLPAIF	SLCO2A1	506	Q92959
FAFQKDVHVPVCPLC	ZFAND2A	46	Q8N6M9
LFPFTERKECPPSCH	WFDC8	156	Q8IUA0
IKCRFFHPERPSCPQ	ZC3H12A	316	Q5D1E8
PCAQCPKHFTPQADL	ZNF398	371	Q8TD17
MCPLCNKVFPSPHIL	ZBTB18	371	Q99592
VFKCPECPLLFVQKP	ZNF592	891	Q92610
KAPHFCPVCLRAFPY	ZNF524	111	Q96C55
PICLHVFVEPVQLPC	TRIM8	16	Q9BZR9
VFVEPVQLPCKHNFC	TRIM8	21	Q9BZR9