Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hexosyltransferase activity	EXTL3 COLGALT1 UGT2B4 UGT2B7 UGT2B10 WDFY3 FUT1	1.51e-04	211	108	7	GO:0016758
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	EXTL3 COLGALT1 UGT2B4 UGT2B7 UGT2B10 WDFY3	1.85e-04	153	108	6	GO:0008194
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity, type I	BMPR1A BMPR1B	2.87e-04	5	108	2	GO:0005025
GeneOntologyMolecularFunction	dATP binding	ST13 ST13P5	2.87e-04	5	108	2	GO:0032564
GeneOntologyMolecularFunction	adenyl deoxyribonucleotide binding	ST13 ST13P5	4.29e-04	6	108	2	GO:0032558
GeneOntologyMolecularFunction	retinoic acid binding	CYP26A1 UGT2B4 UGT2B7	4.57e-04	28	108	3	GO:0001972
GeneOntologyMolecularFunction	purine deoxyribonucleotide binding	ST13 ST13P5	5.98e-04	7	108	2	GO:0032554
GeneOntologyMolecularFunction	unfolded protein binding	ST13 CDC37L1 SYVN1 ST13P5 HSPA8	6.13e-04	126	108	5	GO:0051082
GeneOntologyMolecularFunction	calcium channel activity	CACNA1S RYR1 ITPR3 ORAI1 CHRNA10	6.82e-04	129	108	5	GO:0005262
GeneOntologyMolecularFunction	BMP receptor activity	BMPR1A BMPR1B	7.94e-04	8	108	2	GO:0098821
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1S TMC7 CHRNA4 RYR1 ITPR3 ORAI1 SLC17A8 ANO7 CHRNA10	8.69e-04	459	108	9	GO:0005216
GeneOntologyMolecularFunction	lipid binding	ABCA1 ICA1 CYP26A1 MAP3K1 ITPR3 SPTBN4 ARAP3 PIK3C2G NISCH UGT2B4 UGT2B7 WDFY3 HSPA8 MITD1	8.80e-04	988	108	14	GO:0008289
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B4 UGT2B7 UGT2B10	8.88e-04	35	108	3	GO:0015020
GeneOntologyMolecularFunction	glycosyltransferase activity	EXTL3 COLGALT1 UGT2B4 UGT2B7 UGT2B10 WDFY3 FUT1	9.73e-04	288	108	7	GO:0016757
GeneOntologyMolecularFunction	deoxyribonucleotide binding	ST13 ST13P5	1.02e-03	9	108	2	GO:0032552
GeneOntologyMolecularFunction	protein carrier chaperone	IPO9 ASF1B HSPA8	1.13e-03	38	108	3	GO:0140597
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1S RYR1 ITPR3 ORAI1 CHRNA10	1.38e-03	151	108	5	GO:0015085
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2G PIK3C3	1.54e-03	11	108	2	GO:0016303
GeneOntologyMolecularFunction	protein-folding chaperone binding	ST13 CDC37L1 SYVN1 ST13P5 HSPA8	1.83e-03	161	108	5	GO:0051087
GeneOntologyMolecularFunction	heat shock protein binding	ST13 CDC37L1 CLTC ST13P5 HSPA8	1.93e-03	163	108	5	GO:0031072
GeneOntologyMolecularFunction	transforming growth factor beta receptor activity	BMPR1A BMPR1B	2.17e-03	13	108	2	GO:0005024
GeneOntologyMolecularFunction	channel activity	CACNA1S TMC7 CHRNA4 RYR1 ITPR3 ORAI1 SLC17A8 ANO7 CHRNA10	2.19e-03	525	108	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1S TMC7 CHRNA4 RYR1 ITPR3 ORAI1 SLC17A8 ANO7 CHRNA10	2.22e-03	526	108	9	GO:0022803
GeneOntologyMolecularFunction	retinoid binding	CYP26A1 UGT2B4 UGT2B7	2.23e-03	48	108	3	GO:0005501
GeneOntologyMolecularFunction	gated channel activity	CACNA1S TMC7 CHRNA4 RYR1 ITPR3 ANO7 CHRNA10	2.27e-03	334	108	7	GO:0022836
GeneOntologyMolecularFunction	isoprenoid binding	CYP26A1 UGT2B4 UGT2B7	2.37e-03	49	108	3	GO:0019840
GeneOntologyMolecularFunction	monocarboxylic acid binding	ACACB CYP26A1 UGT2B4 UGT2B7	2.72e-03	107	108	4	GO:0033293
GeneOntologyMolecularFunction	protein domain specific binding	DOCK1 STRN3 ICA1 ST13 PTPN6 KIDINS220 CEP250 CLTC PRKDC ST13P5 HSPA8 MITD1	2.73e-03	875	108	12	GO:0019904
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA1 ERCC6 DNAH10 DYNC2H1 YTHDC2 EIF4A2 MTREX HSPA8	2.73e-03	441	108	8	GO:0016887
GeneOntologyMolecularFunction	histone chaperone activity	IPO9 ASF1B	2.91e-03	15	108	2	GO:0140713
GeneOntologyMolecularFunction	phospholipid binding	ABCA1 ITPR3 SPTBN4 ARAP3 PIK3C2G NISCH WDFY3 HSPA8 MITD1	2.92e-03	548	108	9	GO:0005543
GeneOntologyMolecularFunction	GTPase binding	DOCK1 ATG16L1 STRN3 ABCA1 MYCBP2 IPO9 FGD6	3.44e-03	360	108	7	GO:0051020
GeneOntologyBiologicalProcess	regulation of protein refolding	ST13 ST13P5 HSPA8	2.46e-06	6	104	3	GO:0061083
GeneOntologyBiologicalProcess	biphenyl catabolic process	UGT2B4 UGT2B7 UGT2B10	6.85e-06	8	104	3	GO:0070980
GeneOntologyBiologicalProcess	biphenyl metabolic process	UGT2B4 UGT2B7 UGT2B10	1.46e-05	10	104	3	GO:0018879
GeneOntologyBiologicalProcess	positive regulation by host of viral genome replication	YTHDC2 PIK3C3 HSPA8	2.00e-05	11	104	3	GO:0044829
GeneOntologyBiologicalProcess	xenobiotic glucuronidation	UGT2B4 UGT2B7 UGT2B10	2.65e-05	12	104	3	GO:0052697
GeneOntologyBiologicalProcess	regulation of protein folding	ST13 ST13P5 HSPA8	4.35e-05	14	104	3	GO:1903332
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	ABCA1 CAD CYP26A1 ANKRD1 UGT2B4 UGT2B7 UGT2B10	1.34e-04	222	104	7	GO:0071466
GeneOntologyBiologicalProcess	estrogen metabolic process	BMPR1B UGT2B4 UGT2B7 UGT2B10	1.37e-04	52	104	4	GO:0008210
GeneOntologyBiologicalProcess	modulation by host of viral process	YTHDC2 PIK3C2G PIK3C3 HSPA8	1.37e-04	52	104	4	GO:0044788
GeneOntologyBiologicalProcess	positive regulation of collagen fibril organization	COLGALT1 TNXB	1.50e-04	4	104	2	GO:1904028
GeneOntologyBiologicalProcess	cellular glucuronidation	UGT2B4 UGT2B7 UGT2B10	1.55e-04	21	104	3	GO:0052695
GeneOntologyBiologicalProcess	response to caffeine	CACNA1S CAD RYR1	1.55e-04	21	104	3	GO:0031000
GeneOntologyBiologicalProcess	positive regulation by host of viral process	YTHDC2 PIK3C3 HSPA8	2.05e-04	23	104	3	GO:0044794
GeneOntologyBiologicalProcess	protein localization to microtubule cytoskeleton	CEP250 MAPRE2 PCM1 GOLGB1	2.24e-04	59	104	4	GO:0072698
GeneOntologyBiologicalProcess	negative regulation of protein refolding	ST13 ST13P5	2.49e-04	5	104	2	GO:0061084
GeneOntologyBiologicalProcess	protein localization to cytoskeleton	CEP250 MAPRE2 PCM1 GOLGB1	2.89e-04	63	104	4	GO:0044380
GeneOntologyBiologicalProcess	glucuronate metabolic process	UGT2B4 UGT2B7 UGT2B10	2.98e-04	26	104	3	GO:0019585
GeneOntologyBiologicalProcess	uronic acid metabolic process	UGT2B4 UGT2B7 UGT2B10	2.98e-04	26	104	3	GO:0006063
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	ABCA1 CAD ACACB CYP26A1 ANKRD1 UGT2B4 UGT2B7 UGT2B10 SMPD1 HSPA8	3.22e-04	525	104	10	GO:0009410
GeneOntologyBiologicalProcess	modulation by host of viral genome replication	YTHDC2 PIK3C3 HSPA8	3.72e-04	28	104	3	GO:0044827
GeneOntologyBiologicalProcess	neuromuscular junction development	CACNA1S MYCBP2 PPFIBP2 SPTBN4	3.88e-04	68	104	4	GO:0007528
GeneOntologyCellularComponent	nuclear outer membrane	ITPR3 UGT2B4 UGT2B7 UGT2B10	5.15e-05	40	107	4	GO:0005640
GeneOntologyCellularComponent	Atg12-Atg5-Atg16 complex	ATG16L1 WDFY3	3.84e-04	6	107	2	GO:0034274
GeneOntologyCellularComponent	nuclear membrane	APEH TMEM43 ITPR3 UGT2B4 UGT2B7 UGT2B10 WDFY3 PCM1	4.33e-04	349	107	8	GO:0031965
GeneOntologyCellularComponent	endolysosome	ATG16L1 CLTC SMPD1	4.79e-04	30	107	3	GO:0036019
GeneOntologyCellularComponent	nuclear envelope	APEH TMEM43 ITPR3 IPO9 PIK3C2G UGT2B4 UGT2B7 UGT2B10 WDFY3 PCM1	6.03e-04	560	107	10	GO:0005635
GeneOntologyCellularComponent	HFE-transferrin receptor complex	BMPR1A BMPR1B	7.12e-04	8	107	2	GO:1990712
MousePheno	decreased cochlear inner hair cell number	TMEM43 MAP3K1 TMPRSS3 SLC17A8	3.13e-06	17	87	4	MP:0004396
MousePheno	abnormal hearing physiology	ERCC6 TMEM43 CDC37L1 MAP3K1 SPTBN4 PTCHD1 CEP78 NISCH CEP250 TMPRSS3 SLC17A8 TTI1 CHRNA10 PADI3 ZNF445	8.96e-06	643	87	15	MP:0001963
MousePheno	abnormal auditory brainstem response	ERCC6 TMEM43 CDC37L1 MAP3K1 SPTBN4 PTCHD1 CEP78 NISCH CEP250 TMPRSS3 SLC17A8 TTI1 PADI3 ZNF445	1.17e-05	576	87	14	MP:0004738
MousePheno	abnormal hearing electrophysiology	ERCC6 TMEM43 CDC37L1 MAP3K1 SPTBN4 PTCHD1 CEP78 NISCH CEP250 TMPRSS3 SLC17A8 TTI1 PADI3 ZNF445	1.65e-05	594	87	14	MP:0006335
MousePheno	abnormal ear physiology	ERCC6 TMEM43 CDC37L1 MAP3K1 SPTBN4 PTCHD1 CEP78 NISCH CEP250 TMPRSS3 SLC17A8 TTI1 CHRNA10 PADI3 ZNF445	1.86e-05	684	87	15	MP:0003878
MousePheno	abnormal cochlear inner hair cell number	TMEM43 MAP3K1 TMPRSS3 SLC17A8	3.39e-05	30	87	4	MP:0004394
MousePheno	increased or absent threshold for auditory brainstem response	ERCC6 TMEM43 MAP3K1 SPTBN4 CEP78 NISCH TMPRSS3 SLC17A8	1.09e-04	236	87	8	MP:0011967
MousePheno	abnormal cochlear inner hair cell morphology	ERCC6 TMEM43 MAP3K1 TMPRSS3 SLC17A8 CHRNA10	1.21e-04	124	87	6	MP:0004393
MousePheno	hearing/vestibular/ear phenotype	ERCC6 RPS20 TMEM43 CDC37L1 MAP3K1 SPTBN4 PTCHD1 CEP78 NISCH CEP250 TMPRSS3 SLC17A8 TTI1 CHRNA10 PADI3 ZNF445	1.28e-04	905	87	16	MP:0005377
Domain	PKK	SLK STK10	3.44e-05	2	110	2	IPR022165
Domain	PKK	SLK STK10	3.44e-05	2	110	2	PF12474
Domain	WD40_repeat_CS	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDFY3 TBL2	5.28e-05	164	110	7	IPR019775
Domain	PI3/4_kinase_CS	PIK3C2G PIK3C3 PRKDC	8.59e-05	15	110	3	IPR018936
Domain	-	PIK3C2G PIK3C3 PRKDC	1.05e-04	16	110	3	1.10.1070.11
Domain	PI3Kc	PIK3C2G PIK3C3 PRKDC	1.05e-04	16	110	3	SM00146
Domain	PI3_PI4_kinase	PIK3C2G PIK3C3 PRKDC	1.52e-04	18	110	3	PF00454
Domain	PI3_4_KINASE_1	PIK3C2G PIK3C3 PRKDC	1.52e-04	18	110	3	PS00915
Domain	PI3_4_KINASE_2	PIK3C2G PIK3C3 PRKDC	1.52e-04	18	110	3	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3C2G PIK3C3 PRKDC	1.52e-04	18	110	3	IPR000403
Domain	PI3_4_KINASE_3	PIK3C2G PIK3C3 PRKDC	1.52e-04	18	110	3	PS50290
Domain	ARM-type_fold	DOCK1 MAP3K1 IPO9 PIK3C2G PIK3C3 CLTC TTI1 PRKDC WDFY3	1.79e-04	339	110	9	IPR016024
Domain	WD40	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	1.88e-04	268	110	8	SM00320
Domain	WD40_repeat	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	2.08e-04	272	110	8	IPR001680
Domain	WD_REPEATS_1	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	2.41e-04	278	110	8	PS00678
Domain	UDPGT	UGT2B4 UGT2B7 UGT2B10	2.45e-04	21	110	3	PF00201
Domain	UDPGT	UGT2B4 UGT2B7 UGT2B10	2.45e-04	21	110	3	PS00375
Domain	UDP_glucos_trans	UGT2B4 UGT2B7 UGT2B10	2.45e-04	21	110	3	IPR002213
Domain	WD_REPEATS_2	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	2.47e-04	279	110	8	PS50082
Domain	WD_REPEATS_REGION	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	2.47e-04	279	110	8	PS50294
Domain	CPSASE_1	CAD ACACB	3.40e-04	5	110	2	PS00866
Domain	DDE_Tnp_1_7	ERCC6 PGBD2	3.40e-04	5	110	2	PF13843
Domain	PGBD	ERCC6 PGBD2	3.40e-04	5	110	2	IPR029526
Domain	WD40_repeat_dom	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	3.75e-04	297	110	8	IPR017986
Domain	RIH_assoc-dom	RYR1 ITPR3	5.08e-04	6	110	2	IPR013662
Domain	Ins145_P3_rec	RYR1 ITPR3	5.08e-04	6	110	2	PF08709
Domain	RIH_assoc	RYR1 ITPR3	5.08e-04	6	110	2	PF08454
Domain	RIH_dom	RYR1 ITPR3	5.08e-04	6	110	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR3	5.08e-04	6	110	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR3	5.08e-04	6	110	2	IPR015925
Domain	CPSASE_2	CAD ACACB	5.08e-04	6	110	2	PS00867
Domain	-	RYR1 ITPR3	5.08e-04	6	110	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 ITPR3	5.08e-04	6	110	2	PF01365
Domain	GS_dom	BMPR1A BMPR1B	7.08e-04	7	110	2	IPR003605
Domain	GS	BMPR1A BMPR1B	7.08e-04	7	110	2	PS51256
Domain	CbamoylP_synth_lsu-like_ATP-bd	CAD ACACB	7.08e-04	7	110	2	IPR005479
Domain	BC-like_N	CAD ACACB	7.08e-04	7	110	2	IPR005481
Domain	TGF_beta_GS	BMPR1A BMPR1B	7.08e-04	7	110	2	PF08515
Domain	GS	BMPR1A BMPR1B	7.08e-04	7	110	2	SM00467
Domain	CPSase_L_D2	CAD ACACB	7.08e-04	7	110	2	PF02786
Domain	Biotin_carb_N	CAD ACACB	7.08e-04	7	110	2	PF00289
Domain	-	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	7.95e-04	333	110	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	ATG16L1 STRN3 LRWD1 BRWD3 NWD2 WDR87 WDFY3 TBL2	8.27e-04	335	110	8	IPR015943
Domain	WD40	ATG16L1 STRN3 LRWD1 BRWD3 WDR87 WDFY3 TBL2	8.60e-04	259	110	7	PF00400
Domain	DHC_N1	DNAH10 DYNC2H1	9.40e-04	8	110	2	PF08385
Domain	PI3K_C2	PIK3C2G PIK3C3	9.40e-04	8	110	2	SM00142
Domain	PI3K_C2_dom	PIK3C2G PIK3C3	9.40e-04	8	110	2	IPR002420
Domain	PI3K_C2	PIK3C2G PIK3C3	9.40e-04	8	110	2	PF00792
Domain	PI3K_C2	PIK3C2G PIK3C3	9.40e-04	8	110	2	PS51547
Domain	Dynein_heavy_dom-1	DNAH10 DYNC2H1	9.40e-04	8	110	2	IPR013594
Domain	PI3Ka	PIK3C2G PIK3C3	1.20e-03	9	110	2	PF00613
Domain	PI3Ka	PIK3C2G PIK3C3	1.20e-03	9	110	2	SM00145
Domain	-	PIK3C2G PIK3C3	1.20e-03	9	110	2	1.25.40.70
Domain	MIR	RYR1 ITPR3	1.50e-03	10	110	2	PF02815
Domain	STI1	ST13 ST13P5	1.50e-03	10	110	2	SM00727
Domain	MIR_motif	RYR1 ITPR3	1.50e-03	10	110	2	IPR016093
Domain	PI_Kinase	PIK3C2G PIK3C3	1.50e-03	10	110	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2G PIK3C3	1.50e-03	10	110	2	IPR001263
Domain	Activin_recp	BMPR1A BMPR1B	1.50e-03	10	110	2	PF01064
Domain	MIR	RYR1 ITPR3	1.50e-03	10	110	2	PS50919
Domain	MIR	RYR1 ITPR3	1.50e-03	10	110	2	SM00472
Domain	Activin_recp	BMPR1A BMPR1B	1.50e-03	10	110	2	IPR000472
Domain	PIK_HELICAL	PIK3C2G PIK3C3	1.50e-03	10	110	2	PS51545
Domain	STI1_HS-bd	ST13 ST13P5	1.50e-03	10	110	2	IPR006636
Domain	DHR-1_domain	DOCK1 DOCK6	1.83e-03	11	110	2	IPR027007
Domain	DHR_2	DOCK1 DOCK6	1.83e-03	11	110	2	PS51651
Domain	DHR_1	DOCK1 DOCK6	1.83e-03	11	110	2	PS51650
Domain	DHR-2	DOCK1 DOCK6	1.83e-03	11	110	2	PF06920
Domain	DOCK	DOCK1 DOCK6	1.83e-03	11	110	2	IPR026791
Domain	DOCK_C	DOCK1 DOCK6	1.83e-03	11	110	2	IPR010703
Domain	DOCK-C2	DOCK1 DOCK6	1.83e-03	11	110	2	PF14429
Domain	DHR-2	DOCK1 DOCK6	1.83e-03	11	110	2	IPR027357
Domain	TGFB_receptor	BMPR1A BMPR1B	2.18e-03	12	110	2	IPR000333
Domain	-	CAD ACACB	2.57e-03	13	110	2	3.40.50.20
Domain	TPR_REGION	ST13P4 DNAH10 ST13 PRKDC ST13P5	2.94e-03	165	110	5	PS50293
Domain	TPR	ST13P4 DNAH10 ST13 PRKDC ST13P5	2.94e-03	165	110	5	PS50005
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC2H1	2.99e-03	14	110	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC2H1	2.99e-03	14	110	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC2H1	2.99e-03	14	110	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC2H1	2.99e-03	14	110	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC2H1	2.99e-03	14	110	2	IPR011704
Domain	ATP_GRASP	CAD ACACB	2.99e-03	14	110	2	PS50975
Domain	ATP-grasp	CAD ACACB	2.99e-03	14	110	2	IPR011761
Domain	PreATP-grasp_dom	CAD ACACB	2.99e-03	14	110	2	IPR016185
Domain	MT	DNAH10 DYNC2H1	2.99e-03	14	110	2	PF12777
Domain	AAA_8	DNAH10 DYNC2H1	2.99e-03	14	110	2	PF12780
Domain	AAA_5	DNAH10 DYNC2H1	2.99e-03	14	110	2	PF07728
Domain	DHC_fam	DNAH10 DYNC2H1	3.43e-03	15	110	2	IPR026983
Domain	Dynein_heavy	DNAH10 DYNC2H1	3.43e-03	15	110	2	PF03028
Domain	Dynein_heavy_dom	DNAH10 DYNC2H1	3.43e-03	15	110	2	IPR004273
Domain	-	CAD ACACB	3.43e-03	15	110	2	3.30.1490.20
Domain	Helicase_C	ERCC6 YTHDC2 EIF4A2 MTREX	3.69e-03	107	110	4	PF00271
Domain	HELICc	ERCC6 YTHDC2 EIF4A2 MTREX	3.69e-03	107	110	4	SM00490
Domain	Helicase_C	ERCC6 YTHDC2 EIF4A2 MTREX	3.82e-03	108	110	4	IPR001650
Domain	Nicotinic_acetylcholine_rcpt	CHRNA4 CHRNA10	3.91e-03	16	110	2	IPR002394
Domain	HELICASE_CTER	ERCC6 YTHDC2 EIF4A2 MTREX	3.94e-03	109	110	4	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6 YTHDC2 EIF4A2 MTREX	3.94e-03	109	110	4	PS51192
Domain	DEXDc	ERCC6 YTHDC2 EIF4A2 MTREX	3.94e-03	109	110	4	SM00487
Domain	Helicase_ATP-bd	ERCC6 YTHDC2 EIF4A2 MTREX	4.07e-03	110	110	4	IPR014001
Domain	ATP_grasp_subdomain_1	CAD ACACB	4.95e-03	18	110	2	IPR013815
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRWD1 MYCBP2 APEH LAMB3 EXTL3 RYR1 ITPR3 STK10 ORAI1 ARAP3 KLHL36 NISCH CSPG4 PRKDC WDFY3 FUT1 SYVN1 DOCK6 ABTB2	2.55e-09	1105	112	19	35748872
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	STRN3 MYCBP2 THTPA YTHDC2 TMEM43 COLGALT1 CEP250 TOLLIP TTI1 MTREX DOCK6 PCM1 GOLGB1	1.00e-06	754	112	13	33060197
Pubmed	Defining the membrane proteome of NK cells.	CAD MYCBP2 RPS20 COLGALT1 ITPR3 ORAI1 IPO9 KIDINS220 PIK3C3 NISCH CLTC PRKDC SYVN1 HSPA8 PCM1 GOLGB1	1.09e-06	1168	112	16	19946888
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B4 UGT2B7 UGT2B10	1.13e-06	7	112	3	26074487
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B4 UGT2B7 UGT2B10	1.80e-06	8	112	3	32093886
Pubmed	Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.	UGT2B4 UGT2B7 UGT2B10	1.80e-06	8	112	3	10748067
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CAD MYCBP2 PIK3C3 CEP250 CLTC PRKDC FGD6 HSPA8	1.84e-06	255	112	8	15324660
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	ATG16L1 CAD TMEM43 CLTC PRKDC TBL2 HSPA8 PCM1	2.67e-06	268	112	8	33024031
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	ST13P4 SLK RPS20 ST13 CKS2 IPO9 EIF4A2 CEP250 CLTC PRKDC ST13P5 HSPA8 GOLGB1	3.58e-06	847	112	13	35235311
Pubmed	Connexins modulate autophagosome biogenesis.	ATG16L1 PIK3C3 CLTC	3.84e-06	10	112	3	24705551
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	SLK CAD LRWD1 MYCBP2 APEH TMEM43 COLGALT1 KIDINS220 PIK3C3 EIF4A2 CLTC TOLLIP PRKDC ST13P5 HSPA8 PCM1	4.19e-06	1297	112	16	33545068
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK1 CAD ITPR3 ARAP3 CLTC PRKDC DOCK6	4.35e-06	202	112	7	33005030
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CAD LRWD1 ERCC6 MYCBP2 EXOC3 RPS20 COLGALT1 IPO9 ARAP3 CLTC AKAP10 PRKDC WDFY3 MTREX MAPRE2 HSPA8	7.13e-06	1353	112	16	29467282
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	RNF121 ATG16L1 CLTC WDFY3 SYVN1 HSPA8	9.56e-06	150	112	6	32423001
Pubmed	Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.	CACNA1S RYR1	1.03e-05	2	112	2	12954602
Pubmed	Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.	UGT2B4 UGT2B7	1.03e-05	2	112	2	10222050
Pubmed	Investigating the genetic susceptibility to exertional heat illness.	CACNA1S RYR1	1.03e-05	2	112	2	32054689
Pubmed	Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping.	BMPR1A BMPR1B	1.03e-05	2	112	2	9730621
Pubmed	Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.	CACNA1S RYR1	1.03e-05	2	112	2	21575570
Pubmed	Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues.	BMPR1A BMPR1B	1.03e-05	2	112	2	10850425
Pubmed	Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling.	BMPR1A BMPR1B	1.03e-05	2	112	2	28357470
Pubmed	Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.	CACNA1S RYR1	1.03e-05	2	112	2	12496092
Pubmed	A molecular chaperone complex at the lysosomal membrane is required for protein translocation.	ST13 HSPA8	1.03e-05	2	112	2	11559757
Pubmed	Clinical utility gene card for: malignant hyperthermia.	CACNA1S RYR1	1.03e-05	2	112	2	21248738
Pubmed	Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.	CACNA1S RYR1	1.03e-05	2	112	2	24013571
Pubmed	Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families.	CACNA1S RYR1	1.03e-05	2	112	2	25735680
Pubmed	Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2).	BMPR1A BMPR1B	1.03e-05	2	112	2	15322331
Pubmed	Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.	CACNA1S RYR1	1.03e-05	2	112	2	21262876
Pubmed	Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.	UGT2B4 UGT2B7	1.03e-05	2	112	2	17263731
Pubmed	Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.	SMPD1 PRKDC	1.03e-05	2	112	2	20924105
Pubmed	Increasing the number of diagnostic mutations in malignant hyperthermia.	CACNA1S RYR1	1.03e-05	2	112	2	19191329
Pubmed	BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation.	BMPR1A BMPR1B	1.03e-05	2	112	2	32764110
Pubmed	Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle.	CACNA1S RYR1	1.03e-05	2	112	2	9199552
Pubmed	[BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell].	BMPR1A BMPR1B	1.03e-05	2	112	2	20673479
Pubmed	Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.	UGT2B4 UGT2B7	1.03e-05	2	112	2	15319348
Pubmed	Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells.	MAP3K1 STK10	1.03e-05	2	112	2	11903060
Pubmed	Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation.	CACNA1S RYR1	1.03e-05	2	112	2	35509066
Pubmed	St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.	ST13 ST13P5	1.03e-05	2	112	2	35562743
Pubmed	Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) α(1S) subunit.	CACNA1S RYR1	1.03e-05	2	112	2	23071115
Pubmed	Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development.	BMPR1A BMPR1B	1.03e-05	2	112	2	15102710
Pubmed	Comparison of pathogenicity prediction tools on missense variants in RYR1 and CACNA1S associated with malignant hyperthermia.	CACNA1S RYR1	1.03e-05	2	112	2	27147545
Pubmed	The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.	CACNA1S RYR1	1.03e-05	2	112	2	18556650
Pubmed	Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.	CACNA1S RYR1	1.03e-05	2	112	2	26910427
Pubmed	BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.	BMPR1A BMPR1B	1.03e-05	2	112	2	31769494
Pubmed	Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.	CACNA1S RYR1	1.03e-05	2	112	2	12023238
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	1.03e-05	2	112	2	21150295
Pubmed	SYVN1-MTR4-MAT2A Signaling Axis Regulates Methionine Metabolism in Glioma Cells.	MTREX SYVN1	1.03e-05	2	112	2	33859984
Pubmed	Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness.	CACNA1S RYR1	1.03e-05	2	112	2	25658027
Pubmed	A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.	DYNC2H1 GOLGB1	1.03e-05	2	112	2	24046448
Pubmed	Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres.	CACNA1S RYR1	1.03e-05	2	112	2	30689883
Pubmed	RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.	CACNA1S RYR1	1.03e-05	2	112	2	30325262
Pubmed	BMP signaling mutant mice exhibit glial cell maturation defects.	BMPR1A BMPR1B CSPG4	1.15e-05	14	112	3	17391983
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	DOCK1 CAD RPS20 CLTC PRKDC HSPA8 PCM1	1.17e-05	235	112	7	30258100
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STRN3 SLK CAD MYCBP2 EMSY SPTBN4 NISCH EIF4A2 CLTC WDFY3 HSPA8 PCM1 GOLGB1	1.41e-05	963	112	13	28671696
Pubmed	Identification of potential protein interactors of Lrrk2.	CLTC PRKDC HSPA8	1.44e-05	15	112	3	17400507
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	STRN3 CAD TMEM43 IPO9 NISCH EIF4A2 PRKDC HSPA8 PCM1 GOLGB1	1.50e-05	564	112	10	21565611
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	SLK RPS20 IPO9 KIDINS220 NISCH CLTC PRKDC MAPRE2 GOLGB1	1.56e-05	449	112	9	31732153
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SLK KIDINS220 CLTC PRKDC HSPA8 PCM1 GOLGB1	2.02e-05	256	112	7	33397691
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CAD DYNC2H1 EXOC3 ST13 EMSY CKS2 CLTC MTREX PCM1 GOLGB1	2.14e-05	588	112	10	38580884
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	CAD EXOC3 LAMB3 RPS20 COLGALT1 IPO9 CEP78 CLTC PRKDC HSPA8	2.57e-05	601	112	10	33658012
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	CAD IPO9 CLTC PRKDC MTREX GOLGB1	2.60e-05	179	112	6	36261009
Pubmed	Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice.	CLTC SYVN1 HSPA8	3.03e-05	19	112	3	32888949
Pubmed	Age-Associated Increase in BMP Signaling Inhibits Hippocampal Neurogenesis.	BMPR1A BMPR1B	3.08e-05	3	112	2	25538007
Pubmed	Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.	BMPR1A BMPR1B	3.08e-05	3	112	2	24048844
Pubmed	Distinct developmental programs require different levels of Bmp signaling during mouse retinal development.	BMPR1A BMPR1B	3.08e-05	3	112	2	15673568
Pubmed	Mitsugumin 53 regulates extracellular Ca2+ entry and intracellular Ca2+ release via Orai1 and RyR1 in skeletal muscle.	RYR1 ORAI1	3.08e-05	3	112	2	27841305
Pubmed	cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.	UGT2B4 UGT2B10	3.08e-05	3	112	2	8333863
Pubmed	Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.	CACNA1S RYR1	3.08e-05	3	112	2	16357209
Pubmed	Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .	UGT2B4 UGT2B7	3.08e-05	3	112	2	29138287
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1S RYR1	3.08e-05	3	112	2	11206130
Pubmed	Expression patterns of BMPRs in the developing mouse molar.	BMPR1A BMPR1B	3.08e-05	3	112	2	16432712
Pubmed	Analysis of the native murine bone morphogenetic protein serine threonine kinase type I receptor (ALK-3).	BMPR1A BMPR1B	3.08e-05	3	112	2	8707881
Pubmed	The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.	BMPR1A BMPR1B	3.08e-05	3	112	2	11714695
Pubmed	Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling.	BMPR1A BMPR1B	3.08e-05	3	112	2	23831617
Pubmed	The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development.	BMPR1A BMPR1B	3.08e-05	3	112	2	25413979
Pubmed	Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development.	BMPR1A BMPR1B	3.08e-05	3	112	2	20363875
Pubmed	BMP signaling specifies the development of a large and fast CNS synapse.	BMPR1A BMPR1B	3.08e-05	3	112	2	23708139
Pubmed	Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.	BMPR1A BMPR1B	3.08e-05	3	112	2	7750489
Pubmed	BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury.	BMPR1A BMPR1B	3.08e-05	3	112	2	20130193
Pubmed	Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.	ITPR3 KIDINS220	3.08e-05	3	112	2	18539593
Pubmed	Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.	CACNA1S RYR1	3.08e-05	3	112	2	8943043
Pubmed	Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.	BMPR1A BMPR1B	3.08e-05	3	112	2	8605097
Pubmed	Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of RYR1, CACNA1S and STAC3 variants.	CACNA1S RYR1	3.08e-05	3	112	2	31559918
Pubmed	Role of type I receptors for anti-Müllerian hormone in the SMAT-1 Sertoli cell line.	BMPR1A BMPR1B	3.08e-05	3	112	2	15897891
Pubmed	Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.	BMPR1A BMPR1B	3.08e-05	3	112	2	26584636
Pubmed	Expression of bone morphogenetic protein receptors in the developing mouse metanephros.	BMPR1A BMPR1B	3.08e-05	3	112	2	11701996
Pubmed	Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13.	UGT2B4 UGT2B7	3.08e-05	3	112	2	7835904
Pubmed	Malignant Hyperthermia Susceptibility	CACNA1S RYR1	3.08e-05	3	112	2	20301325
Pubmed	Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70.	PRKDC HSPA8	3.08e-05	3	112	2	8940078
Pubmed	Interactions of the scid or beige mutations with the viable motheaten mutation.	PTPN6 PRKDC	3.08e-05	3	112	2	8781712
Pubmed	ORAI1 deficiency impairs activated T cell death and enhances T cell survival.	ORAI1 PRKDC	3.08e-05	3	112	2	21873530
Pubmed	Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1.	RYR1 ORAI1	3.08e-05	3	112	2	18772199
Pubmed	STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor.	CACNA1S RYR1	3.08e-05	3	112	2	30071129
Pubmed	The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors.	BMPR1A BMPR1B	3.08e-05	3	112	2	19726563
Pubmed	STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function.	CACNA1S RYR1	3.08e-05	3	112	2	30543836
Pubmed	The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain.	CLTC HSPA8	3.08e-05	3	112	2	26345367
Pubmed	Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels.	CACNA1S RYR1	3.08e-05	3	112	2	25548159
Pubmed	Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.	SLK STK10	3.08e-05	3	112	2	23209304
Pubmed	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.	UGT2B4 UGT2B7	3.08e-05	3	112	2	22092298
Pubmed	Protein phosphatase 6 dissociates the Beclin 1/Vps34 complex and inhibits autophagy.	PTPN6 PIK3C3	3.08e-05	3	112	2	33751937
Interaction	ST13 interactions	ST13P4 SLK RPS20 ST13 IPO9 ASF1B CLTC ST13P5 HSPA8	1.33e-06	195	111	9	int:ST13
Interaction	ST13P4 interactions	ST13P4 ST13 ST13P5 HSPA8	3.17e-06	19	111	4	int:ST13P4
Interaction	TOP3B interactions	CAD LRWD1 MYCBP2 APEH LAMB3 RPS20 EXTL3 RYR1 ITPR3 STK10 ORAI1 ARAP3 KLHL36 NISCH EIF4A2 CSPG4 PRKDC WDFY3 FUT1 SYVN1 DOCK6 ABTB2	1.44e-05	1470	111	22	int:TOP3B
Interaction	CLTC interactions	ATG16L1 SLK CAD COLGALT1 ST13 BMPR1A IPO9 KIDINS220 CLTC TOLLIP SYVN1 HSPA8 PCM1 MITD1	1.47e-05	655	111	14	int:CLTC
Interaction	ST13P5 interactions	ST13P4 ST13 ST13P5	3.45e-05	12	111	3	int:ST13P5
Interaction	YWHAQ interactions	CACNA1S ATG16L1 SLK CAD MYCBP2 PPFIBP2 MAP3K1 BMPR1A IPO9 PIK3C3 CEP250 CLTC PRKDC MTREX FGD6 HSPA8 PCM1 GOLGB1	3.81e-05	1118	111	18	int:YWHAQ
Interaction	TRIM33 interactions	SLK CAD RUNX1T1 ST13 IPO9 CEP78 CLTC PRKDC MTREX HSPA8 GOLGB1	4.12e-05	453	111	11	int:TRIM33
Interaction	BGLT3 interactions	CAD CLTC PRKDC TBL2 HSPA8	5.88e-05	75	111	5	int:BGLT3
Interaction	ATG16L1 interactions	ATG16L1 ACACB MYCBP2 EXOC3 YTHDC2 ITPR3 IPO9 ARAP3 CEP78 PIK3C3 CEP250 CLTC AKAP10 WDFY3 MTREX TBL2 PCM1 GOLGB1	6.22e-05	1161	111	18	int:ATG16L1
GeneFamily	WD repeat domain containing	ATG16L1 STRN3 LRWD1 BRWD3 WDR87 WDFY3 TBL2	8.17e-05	262	72	7	362
GeneFamily	UDP glucuronosyltransferases	UGT2B4 UGT2B7 UGT2B10	2.76e-04	32	72	3	363
GeneFamily	Type 1 receptor serine/threonine kinases	BMPR1A BMPR1B	3.24e-04	7	72	2	345
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2G PIK3C3	4.31e-04	8	72	2	831
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA4 CHRNA10	1.81e-03	16	72	2	173
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#5_top-relative-expression-ranked_500	KLHL6 SLK ICA1 PTPN6 ARAP3 DOCK6 FGD6 HSPA8	5.68e-06	193	106	8	DevelopingKidney_e15.5_Endothelial cells_emap-29977_k5_500
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_200	ABCA1 EXTL3 RUNX1T1 ARAP3 PDE5A ELAC1 MAPRE2	1.58e-05	160	106	7	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_200
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#4_top-relative-expression-ranked_500	KLHL6 ABCA1 ICA1 PTPN6 ARAP3 DOCK6 HSPA8	1.09e-04	217	106	7	gudmap_developingKidney_e15.5_Endothelial cells_500_k4
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_1000	KLHL6 DOCK1 ABCA1 SLK MYCBP2 ICA1 STK10 PTPN6 ARAP3 AKAP10 DOCK6 FGD6 HSPA8	1.12e-04	764	106	13	DevelopingKidney_e15.5_Endothelial cells_emap-29977_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29965_top-relative-expression-ranked_500	KLHL6 DOCK1 ABCA1 ICA1 STK10 PTPN6 ARAP3 DOCK6 HSPA8	1.32e-04	384	106	9	gudmap_developingKidney_e15.5_Endothelial cells_500
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_500	KLHL6 DOCK1 SLK ICA1 PTPN6 ARAP3 DOCK6 FGD6 HSPA8	1.32e-04	384	106	9	DevelopingKidney_e15.5_Endothelial cells_emap-29977_500
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 MYCBP2 DYNC2H1 CARMIL3 NISCH CLTC PDE5A PCM1 GOLGB1	1.43e-09	195	110	9	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 MYCBP2 DYNC2H1 CARMIL3 NISCH CLTC PCM1 GOLGB1	3.03e-08	195	110	8	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACB PPFIBP2 THTPA PTCHD1 BMPR1B PRKDC FGD6	1.90e-07	166	110	7	35db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCell	Biopsy_IPF-Epithelial-KRT5-/KRT17+\|Biopsy_IPF / Sample group, Lineage and Cell type	TMC7 LAMB3 SYCE1L ITPR3 TMEM132D ANKRD1 FGD6	6.67e-07	200	110	7	2fc7a3b3aea711ad3d96fd9513f4b40533056d86
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|Epithelial / Disease state, Lineage and Cell class	LAMB3 SYCE1L TMEM132D ANKRD1 FGD6 ABTB2	7.57e-06	189	110	6	4178be3292ff4a8a1d8098f638d4b8d15164d2c6
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	ICA1 EXTL3 BMPR1B PXDNL ANKRD1 UGT2B7	7.80e-06	190	110	6	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 COLGALT1 KIDINS220 NISCH EIF4A2 CLTC	7.80e-06	190	110	6	1d92be1b41cff59e834a9d28868f554bd1f3e471
Drug	2-AF	APEH UGT2B4 UGT2B7 UGT2B10 SMPD1	1.50e-06	41	109	5	CID000005800
Drug	2-hydroxyestriol	UGT2B4 UGT2B7 UGT2B10	2.11e-06	6	109	3	CID000014688
Drug	N'-nitrosoanabasine	UGT2B4 UGT2B7 UGT2B10 SMPD1	3.40e-06	22	109	4	CID000014335
Drug	Theobromine [83-67-0]; Up 200; 22.2uM; MCF7; HT_HG-U133A	ACACB ICA1 YTHDC2 TMPRSS3 WDFY3 CHRNA10 TBL2 PADI3	4.91e-06	197	109	8	3334_UP
Drug	Ticarcillin sodium [4697-14-7]; Up 200; 9.4uM; HL60; HT_HG-U133A	LAMB3 EXTL3 RUNX1T1 CHRNA4 RYR1 KLHL36 CEP250 UGT2B4	5.09e-06	198	109	8	6146_UP
Drug	Urapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; MCF7; HT_HG-U133A	DYNC2H1 JMJD4 EXTL3 CDC37L1 EMSY ITPR3 STK10 IPO9	5.09e-06	198	109	8	5295_UP
Drug	S)-cotinine	RUNX1T1 CHRNA4 UGT2B4 UGT2B7 UGT2B10 CHRNA10	7.27e-06	97	109	6	CID000000408
Drug	amiloride	CACNA1S CHRNA4 RYR1 ORAI1 CLTC SLC17A8 PDE5A SMPD1 CHRNA10	2.10e-05	315	109	9	CID000016230
Drug	Piretanide [55837-27-9]; Up 200; 11uM; HL60; HT_HG-U133A	ACACB CPN1 EXTL3 RUNX1T1 CHRNA4 KLHL36 ANKRD1	3.92e-05	192	109	7	6144_UP
Drug	Niclosamide [50-65-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	STRN3 CYP26A1 YTHDC2 EXTL3 EMSY KIDINS220 WDFY3	4.05e-05	193	109	7	4136_DN
Drug	Florfenicol [73231-34-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	DOCK1 ICA1 LAMB3 EXTL3 EMSY SMPD1 PCM1	4.62e-05	197	109	7	5300_UP
Drug	Colchicine [64-86-8]; Down 200; 10uM; MCF7; HT_HG-U133A	ABCA1 CYP26A1 YTHDC2 EXTL3 MAP3K1 TMPRSS3 PCM1	4.62e-05	197	109	7	5675_DN
Drug	cADPR	CACNA1S EXTL3 RYR1 ITPR3 SMPD1	4.67e-05	82	109	5	CID000123847
Drug	Austricine [10180-88-8]; Up 200; 14.2uM; HL60; HT_HG-U133A	STRN3 ACACB LAMB3 YTHDC2 RPS20 SMPD1 ELAC1	4.77e-05	198	109	7	2157_UP
Drug	Enalapril maleate [76095-16-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	DYNC2H1 YTHDC2 MAP3K1 ITPR3 IPO9 DOCK6 MAPRE2	4.77e-05	198	109	7	7428_UP
Disease	HMG CoA reductase inhibitor use measurement	ABCA1 CYP26A1 ITPR3 BMPR1B UGT2B7 UGT2B10 DOCK6 MAPRE2	4.63e-07	189	107	8	EFO_0009932
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B4 UGT2B7 UGT2B10	3.83e-06	9	107	3	EFO_0600040
Disease	Malignant hyperthermia, susceptibility to	CACNA1S RYR1	1.30e-05	2	107	2	cv:C5437603
Disease	Malignant hyperthermia	CACNA1S RYR1	1.30e-05	2	107	2	cv:C5779784
Disease	Cone-rod dystrophy and hearing loss	CEP78 CEP250	1.30e-05	2	107	2	cv:CN263092
Disease	Malignant hyperpyrexia due to anesthesia	CACNA1S RYR1	1.30e-05	2	107	2	C0024591
Disease	malignant hyperthermia (is_implicated_in)	CACNA1S RYR1	3.90e-05	3	107	2	DOID:8545 (is_implicated_in)
Disease	Familial Colorectal Cancer Type X	RPS20 BMPR1A	3.90e-05	3	107	2	C3896578
Disease	Rare disease with malignant hyperthermia	CACNA1S RYR1	7.78e-05	4	107	2	cv:C5681128
Disease	angina pectoris	DYNC2H1 BRWD3 BMPR1B IPO9 FGD6	9.48e-05	125	107	5	EFO_0003913
Disease	vanillylmandelate (VMA) measurement	UGT2B4 UGT2B10	2.70e-04	7	107	2	EFO_0800119
Disease	deoxycholic acid glucuronide measurement	UGT2B7 UGT2B10	3.60e-04	8	107	2	EFO_0800575
Disease	pantothenate measurement	ABCA1 CAD	3.60e-04	8	107	2	EFO_0021034
Disease	high density lipoprotein particle size measurement	ABCA1 DNAH10 CYP26A1 NISCH DOCK6	3.96e-04	170	107	5	EFO_0008592
Disease	serum gamma-glutamyl transferase measurement	ICA1 CYP26A1 CPN1 EMSY UGT2B4 UGT2B7 UGT2B10 SLC17A8 FUT1 MAPRE2 TBL2	4.92e-04	914	107	11	EFO_0004532
Disease	total lipids in lipoprotein particles measurement	ABCA1 FUT1 DOCK6	7.12e-04	48	107	3	EFO_0022309
Disease	Congenital myopathy (disorder)	CACNA1S RYR1	8.40e-04	12	107	2	C0270960
Disease	Autosomal Dominant Myotubular Myopathy	RYR1 ORAI1	9.90e-04	13	107	2	C3661489
Disease	Centronuclear myopathy	RYR1 ORAI1	9.90e-04	13	107	2	C0175709
Disease	juvenile polyposis syndrome (implicated_via_orthology)	BMPR1A BMPR1B	9.90e-04	13	107	2	DOID:0050787 (implicated_via_orthology)
Disease	X-linked centronuclear myopathy	RYR1 ORAI1	9.90e-04	13	107	2	C0410203
Disease	Myopathy, Centronuclear, 1	RYR1 ORAI1	9.90e-04	13	107	2	C4551952
Disease	X-19141 measurement	UGT2B4 UGT2B7	9.90e-04	13	107	2	EFO_0800799
Disease	Congenital Structural Myopathy	RYR1 ORAI1	9.90e-04	13	107	2	C0752282
Disease	Myopathy, Centronuclear, Autosomal Dominant	RYR1 ORAI1	1.15e-03	14	107	2	C1834558
Disease	Tubular Aggregate Myopathy	RYR1 ORAI1	1.15e-03	14	107	2	C0410207
Disease	Autosomal Recessive Centronuclear Myopathy	RYR1 ORAI1	1.33e-03	15	107	2	C3645536
Disease	vitamin D measurement	ABCA1 CYP26A1 ST13 UGT2B4 UGT2B7 UGT2B10	1.44e-03	336	107	6	EFO_0004631
Disease	Eye Abnormalities	BMPR1A BMPR1B	1.71e-03	17	107	2	C0015393
Disease	diverticular disease	BMPR1B NISCH TMPRSS3 UGT2B4 UGT2B7	1.72e-03	236	107	5	EFO_0009959
Disease	neuritic plaque measurement	DOCK1 DYNC2H1 PXDNL UGT2B4 UGT2B7 MAPRE2	1.74e-03	349	107	6	EFO_0006798
Disease	Sclerocystic Ovaries	CARMIL3 EMSY SPTBN4 CKS2	1.90e-03	144	107	4	C1136382
Disease	Polycystic Ovary Syndrome	CARMIL3 EMSY SPTBN4 CKS2	1.90e-03	144	107	4	C0032460
Disease	Congenital Fiber Type Disproportion	RYR1 ORAI1	1.92e-03	18	107	2	C0546264
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	ABCA1 ACACB DNAH10 CYP26A1 DOCK6	1.95e-03	243	107	5	EFO_0004612, EFO_0020944
Disease	rheumatoid arthritis, ulcerative colitis	APEH EMSY	2.62e-03	21	107	2	EFO_0000685, EFO_0000729
Disease	X-24947 measurement	UGT2B4 UGT2B7	2.87e-03	22	107	2	EFO_0800910
Disease	cholesterol in large HDL measurement	ABCA1 CYP26A1 DOCK6	3.11e-03	80	107	3	EFO_0021900
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	ABCA1 ACACB DNAH10 CYP26A1	3.18e-03	166	107	4	EFO_0004530, EFO_0004611
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	ABCA1 ACACB CYP26A1 UGT2B10 DOCK6	3.28e-03	274	107	5	EFO_0004530, EFO_0004612
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	ABCA1 ACACB DNAH10 CYP26A1 DOCK6	3.38e-03	276	107	5	EFO_0004612, EFO_0020943
Disease	HDL cholesterol change measurement	ABCA1 DOCK6	3.41e-03	24	107	2	EFO_0007805

Protein segments in the cluster

Peptide	Gene	Start	Entry
HEDWKRLARVMDRFF	CHRNA10	416	Q9GZZ6
LVNMHSRVDQLDFWE	CHRNA4	191	P43681
MWREVRREVQQTHAV	EGFL8	81	Q99944
MDLWVTFEIREHGEL	ARAP3	1161	Q8WWN8
SWRMVEEQLIRYVHD	CSPG4	1421	Q6UVK1
RRMEHLVKFWLEAES	AKAP10	146	O43572
FRDMLESTAIHWASR	ANKRD1	181	Q15327
IVHLFEDDMVEVWRR	SMPD1	136	P17405
IRFWDIRSESIVREM	ATG16L1	471	Q676U5
EVMSRARVFDWHKRF	GVQW3	36	Q3ZCU0
VRMLLDSRDNDHFWE	ABCA1	436	O95477
RRISALMWEVRYIEH	BRWD3	1201	Q6RI45
KYQTMRRHEETWAES	CEP78	201	Q5JTW2
WFRETEIYQTVLMRH	BMPR1B	241	O00238
SVLHTEEMRFLREWV	ST13P5	21	Q8NFI4
SVLHTEEMRFLREWV	ST13	21	P50502
MFVNLTFREVRHWRS	NWD2	611	Q9ULI1
WDERTVSEMHTILRR	PIK3C2G	701	O75747
SFLHNEMEWQRKLRS	ITPR3	2176	Q14573
EFTQWRVRMISEELV	LRWD1	186	Q9UFC0
SHVHIQSMLRRWFVE	ACACB	2351	O00763
MHRTWRETFLDNLRA	ANO7	136	Q6IWH7
LTRWEMHRTQTKFED	ANO7	571	Q6IWH7
RRMFWEQRTDVHNVL	ERCC6	666	P0DP91
WHLFRSTVLEMRNAE	KIDINS220	1266	Q9ULH0
YDHRTDVWEERRPMT	KLHL36	466	Q8N4N3
EEAQVFETVMSWVRH	KLHL6	231	Q8WZ60
RTLTWEAMEQIRYLH	NGRN	81	Q9NPE2
RQEEMIDHRLTDREW	RUNX1T1	336	Q06455
SAMRRAEATWHIAEE	CARMIL3	1216	Q8ND23
ADMLEWLQDIERHYR	C1orf109	136	Q9NX04
ERMHRHIELAWAFST	ORAI1	166	Q96D31
SIVDNELWSEMRRHE	PCM1	816	Q15154
REMVNAWFAERVHTI	PDE5A	51	O76074
DIRHQMALDWVSREQ	LIX1L	271	Q8IVB5
RRWRFDATLEIIVVM	PADI3	66	Q9ULW8
WETMHRQDVVRIVGE	PDP1	421	Q9P0J1
HRVMEWLRSVDLAEY	PPFIBP2	721	Q8ND30
HTLWFREHNRMATEL	PXDNL	971	A1KZ92
EFLMNWHDRLRKVEE	DYNC2H1	1161	Q8NCM8
WHDRLRKVEEHSVMT	DYNC2H1	1166	Q8NCM8
VTRFHINWDNNMDRL	ASF1B	146	Q9NVP2
LRDSDHKFEWTRMEF	HENMT1	176	Q5T8I9
SQVEPETRAVIRWMH	CPN1	191	P15169
ETRAVIRWMHSFNFV	CPN1	196	P15169
RSVRHMIYDLIEWRS	DOCK1	116	Q14185
AAVEMYIEDWVIVHR	DOCK6	111	Q96HP0
MQIELRHREWVHSDF	CACNA1S	981	Q13698
HDEIMFGFRVWREAR	EXTL3	751	O43909
WMDRETRALADSHFR	JMJD4	46	Q9H9V9
WREVVTFRRHFLEMK	CEP250	181	Q9BV73
WFRETEIYQTVLMRH	BMPR1A	271	P36894
VDWLTEKMHARDFTV	EIF4A2	286	Q14240
ETMSRHDIIAWVNDI	MAPRE2	56	Q15555
LEFVMAEWTSRQHLF	IPO9	836	Q96P70
LGDFWTRMEELRHQA	LAMB3	1036	Q13751
EHSWERGERLDMQAL	CYP26A1	276	O43174
ASRRQDWSEHEIAME	EMSY	741	Q7Z589
DTRESDKMWLVRHLE	EXOC3	266	O60645
RERTALWVATDHNMD	COLGALT1	81	Q8NBJ5
RASDVDHMVRWYLAI	DNAH10	821	Q8IVF4
ELVSHMVVRWAQEDF	RYR1	2096	P21817
MLSRWDDSQRFLSDH	CDC37L1	171	Q7L3B6
RRFDDAVVQSDMKHW	HSPA8	76	P11142
HRAISDTWLTVNRME	ICA1	146	Q05084
ERRMKWHSEDEIRIT	NXF2	86	Q9GZY0
NWNVREMALRRLSHD	MAP3K1	576	Q13233
MDWFRARHEAPVFVV	FUT1	246	P19526
TWDRFQMRIHKRLID	RPS20	76	P60866
FHWLAEDRVDFMERS	SYVN1	116	Q86TM6
SILHTQEMRFLREWV	ST13P4	21	Q8IZP2
WARFEMERAHWEVER	STRN3	76	Q13033
MERAHWEVERAELQA	STRN3	81	Q13033
TNHNIRLFEDVRSWM	TRIM43	296	Q96BQ3
RRHVEMYQWVETEES	TMEM43	116	Q9BTV4
MRAREAAIWELEERH	SLK	1001	Q9H2G2
QVLFHIMGRDWDDRS	TMEM132D	146	Q14C87
SIHDREIRFNNGWMI	MITD1	191	Q8WV92
EMLSSWRKTREDQHV	PTCHD1	346	Q96NR3
HMVKVDWLDRLTFRE	PIK3C3	186	Q8NEB9
FTWNINHARLMVVEE	PRELID1	96	Q9Y255
AIRMEATRVREEWEH	MYCBP2	3976	O75592
DLWEFHMLEQRLARE	SYCE1L	136	A8MT33
VHTEWTQRDLERMEN	APEH	46	P13798
FRWMVDTRISVRIHE	ABTB2	211	Q8N961
KMREHLELFWSRVNI	CLTC	1331	Q00610
HLMSEEEWRRLGVQQ	CKS2	36	P33552
LETESRFDMIGHWII	PGBD2	541	Q6P3X8
RVTSFLDWIHEQMER	TMPRSS3	436	P57727
EMRIIDFFWTLTNHL	TAS2R7	81	Q9NYW3
EISQWMFTHIAVVRD	WDFY3	2306	Q8IZQ1
EVMREVAWVIFDEIH	MTREX	241	P42285
PLDRAVFWIEFVMRH	UGT2B4	456	P06133
LRDREAALWEMEEHQ	STK10	736	O94804
RMHLLEETTVRTEWT	TNXB	756	P22105
DERAFSMDDRIAWTH	TOLLIP	121	Q9H0E2
ERMLHWTEQQRIADI	FGD6	941	Q6ZV73
EELRHLMWSSVVFYQ	NISCH	1156	Q9Y2I1
SLMQADHWLRRREDS	THTPA	46	Q9BU02
MEQARDHLHLRWTTE	SNURFL	1	B1AK76
AQRFDHKVAMRESWL	SPTBN4	431	Q9H254
DLSPEEQWRVEHARM	RNF121	26	Q9H920
DFIWRTMELSHTELV	ELAC1	101	Q9H777
LRLDSVVQWMEHFET	CAD	1566	P27708
NALEEWSIYIDRHVM	PRKDC	771	P78527
MVRWFHRDLSGLDAE	PTPN6	1	P29350
PTDWLIYDEMTRAHR	YTHDC2	1031	Q9H6S0
WRSNFTRHMRLHEEE	ZNF445	636	P59923
LDRAVFWIEFVMRHK	UGT2B10	456	P36537
TNHNIRLFEDVRSWM	TRIM43B	296	A6NCK2
PLDRAVFWIEFVMRH	UGT2B7	456	P16662
SLSDVEWIRHVLERM	WDR87	2521	Q6ZQQ6
IWSTKDFLQREHRSM	TBL2	116	Q9Y4P3
REMTTHLELWREDIR	TMC7	136	Q7Z402
HRVAELMVYREADWV	TTI1	266	O43156
MTRHKTREEWQNVFL	SLC17A8	471	Q8NDX2
QLRMEKSSWEIHERR	GOLGB1	2951	Q14789