Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidase activity	USP17L7 ADAMTS19 TPSAB1 USP17L4 USP17L2 USP17L1 USP17L3 ADAMTS20 KLK9 TMPRSS5 PSMD14 TPSB2 USP17L8	8.41e-08	654	62	13	GO:0008233
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 USP17L8	1.11e-07	124	62	7	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 USP17L8	2.20e-07	137	62	7	GO:0019783
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.44e-06	114	62	6	GO:0004843
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	2.87e-05	192	62	6	GO:0008234
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS19 TPSAB1 ADAMTS20 KLK9 TMPRSS5 PSMD14 TPSB2	3.62e-04	430	62	7	GO:0004175
GeneOntologyMolecularFunction	kinase binding	TRIM64B PTPN6 NBEAL1 NTRK1 PXN DGKD SPG11 TRIM64 TSKS TRIM64C	7.47e-04	969	62	10	GO:0019900
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM64B UBR1 RAG2 CUL9 TRIM64 TRIM64C	1.02e-03	372	62	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM64B UBR1 RAG2 CUL9 TRIM64 TRIM64C	1.45e-03	398	62	6	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	TRIM64B UBR1 RAG2 CUL9 TRIM64 ZDHHC1 TRIM64C TAFAZZIN	2.63e-03	775	62	8	GO:0016746
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TPSAB1 KLK9 TMPRSS5 TPSB2	2.88e-03	190	62	4	GO:0004252
GeneOntologyMolecularFunction	transition metal ion binding	TRIM64B UBR1 RAG2 KDM5A CYP8B1 ADAMTS20 CUL9 TRIM64 TRIM64C HEPH	3.42e-03	1189	62	10	GO:0046914
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM64B UBR1 RAG2 CUL9 TRIM64 TRIM64C	3.43e-03	473	62	6	GO:0004842
GeneOntologyMolecularFunction	serine-type peptidase activity	TPSAB1 KLK9 TMPRSS5 TPSB2	3.91e-03	207	62	4	GO:0008236
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 USP17L8	8.43e-08	125	61	7	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 USP17L8	2.22e-07	144	61	7	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L7 TRIM64B UBR1 USP17L4 USP17L2 USP17L1 USP17L3 CUL9 TRIM64 PSMD14 TRIM64C USP17L8	3.33e-05	1009	61	12	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L7 TRIM64B UBR1 USP17L4 USP17L2 USP17L1 USP17L3 CUL9 TRIM64 PSMD14 TRIM64C USP17L8	6.10e-05	1074	61	12	GO:0043687
Domain	UCH	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.39e-07	71	63	6	PF00443
Domain	USP_2	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.39e-07	71	63	6	PS00973
Domain	USP_3	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.52e-07	72	63	6	PS50235
Domain	USP_dom	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.52e-07	72	63	6	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.52e-07	72	63	6	IPR001394
Domain	USP_CS	USP17L7 USP17L2 USP17L1 USP17L3 USP17L8	2.83e-06	66	63	5	IPR018200
Domain	USP_1	USP17L7 USP17L4 USP17L2 USP17L3 USP17L8	3.80e-06	70	63	5	PS00972
Domain	HABP4_PAI-RBP1	USP17L7 USP17L2 USP17L3	1.99e-05	16	63	3	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L7 USP17L2 USP17L3	1.99e-05	16	63	3	IPR006861
Domain	TSP_1	ADAMTS19 SBSPON ADAMTS20 ISM2	6.03e-05	63	63	4	PF00090
Domain	TSP1	ADAMTS19 SBSPON ADAMTS20 ISM2	6.82e-05	65	63	4	SM00209
Domain	TSP1_rpt	ADAMTS19 SBSPON ADAMTS20 ISM2	6.82e-05	65	63	4	IPR000884
Domain	TSP1	ADAMTS19 SBSPON ADAMTS20 ISM2	6.82e-05	65	63	4	PS50092
Domain	TRYPSIN_SER	TPSAB1 KLK9 TMPRSS5 TPSB2	2.42e-04	90	63	4	IPR033116
Domain	TRYPSIN_HIS	TPSAB1 KLK9 TMPRSS5 TPSB2	4.05e-04	103	63	4	IPR018114
Domain	TRYPSIN_SER	TPSAB1 KLK9 TMPRSS5 TPSB2	4.51e-04	106	63	4	PS00135
Domain	TRYPSIN_HIS	TPSAB1 KLK9 TMPRSS5 TPSB2	4.68e-04	107	63	4	PS00134
Domain	Peptidase_S1A	TPSAB1 KLK9 TMPRSS5 TPSB2	5.75e-04	113	63	4	IPR001314
Domain	TRYPSIN_DOM	TPSAB1 KLK9 TMPRSS5 TPSB2	6.14e-04	115	63	4	PS50240
Domain	Tryp_SPc	TPSAB1 KLK9 TMPRSS5 TPSB2	6.55e-04	117	63	4	SM00020
Domain	Trypsin	TPSAB1 KLK9 TMPRSS5 TPSB2	7.43e-04	121	63	4	PF00089
Domain	Trypsin_dom	TPSAB1 KLK9 TMPRSS5 TPSB2	7.43e-04	121	63	4	IPR001254
Domain	Peptidase_S1_PA	TPSAB1 KLK9 TMPRSS5 TPSB2	7.90e-04	123	63	4	IPR009003
Domain	ADAM_spacer1	ADAMTS19 ADAMTS20	2.71e-03	23	63	2	IPR010294
Domain	ADAM_spacer1	ADAMTS19 ADAMTS20	2.71e-03	23	63	2	PF05986
Domain	JmjC	KDM5A JMJD4	2.95e-03	24	63	2	PF02373
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTS20	2.95e-03	24	63	2	IPR013273
Domain	JMJC	KDM5A JMJD4	5.20e-03	32	63	2	PS51184
Domain	JmjC_dom	KDM5A JMJD4	5.20e-03	32	63	2	IPR003347
Domain	JmjC	KDM5A JMJD4	5.53e-03	33	63	2	SM00558
Domain	Peptidase_M12B_N	ADAMTS19 ADAMTS20	7.66e-03	39	63	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS19 ADAMTS20	7.66e-03	39	63	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS20	8.04e-03	40	63	2	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS20	8.04e-03	40	63	2	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS20	8.04e-03	40	63	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS20	8.04e-03	40	63	2	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS20	8.04e-03	40	63	2	IPR001590
Domain	Disintegrin_dom	ADAMTS19 ADAMTS20	8.44e-03	41	63	2	IPR001762
Pathway	REACTOME_RAS_PROCESSING	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.55e-09	45	45	6	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 TRRAP USP17L8	1.38e-07	191	45	8	MM15289
Pathway	REACTOME_DEUBIQUITINATION	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 TRRAP USP17L8	1.52e-06	262	45	8	MM15286
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 TRRAP USP17L8	5.79e-06	221	45	7	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 TRRAP USP17L8	4.09e-05	299	45	7	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 PSMD14 USP17L8	6.05e-05	318	45	7	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L7 ADAMTS19 USP17L4 USP17L2 USP17L1 NUP37 SBSPON USP17L3 JMJD4 ADAMTS20 SEC31A PSMD14 TRRAP USP17L8	6.75e-05	1389	45	14	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS19 USP17L4 USP17L2 USP17L1 NUP37 SBSPON USP17L3 JMJD4 ADAMTS20 CUL9 SEC31A PSMD14 TRRAP USP17L8	1.30e-04	1475	45	14	M19806
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SBSPON ADAMTS20	2.56e-04	39	45	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SBSPON ADAMTS20	2.56e-04	39	45	3	MM15165
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	7.02e-15	10	65	6	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	3.08e-14	12	65	6	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	9.98e-14	14	65	6	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	8.95e-13	19	65	6	28067227
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.78e-12	21	65	6	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	2.45e-12	22	65	6	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.41e-12	24	65	6	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.79e-12	25	65	6	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	7.52e-12	26	65	6	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.54e-11	29	65	6	32527007
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	3.58e-11	33	65	6	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	4.34e-11	34	65	6	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.23e-11	35	65	6	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.23e-11	35	65	6	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	6.27e-11	36	65	6	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	7.47e-11	37	65	6	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.01e-10	50	65	6	31806660
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	9.78e-09	81	65	6	12838346
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L7 USP17L4 USP17L1 USP17L3 USP17L8	3.14e-08	48	65	5	16421571
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM64B TRIM64 TRIM64C	2.79e-06	15	65	3	19703589
Pubmed	The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.	TPSAB1 TPSB2	3.44e-06	2	65	2	10500112
Pubmed	Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.	TPSAB1 TPSB2	3.44e-06	2	65	2	8434231
Pubmed	Cloning and characterization of a second complementary DNA for human tryptase.	TPSAB1 TPSB2	3.44e-06	2	65	2	2203827
Pubmed	Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.	TPSAB1 TPSB2	3.44e-06	2	65	2	10898108
Pubmed	Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.	TPSAB1 TPSB2	3.44e-06	2	65	2	9521329
Pubmed	Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.	TPSAB1 TPSB2	3.44e-06	2	65	2	2187193
Pubmed	Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.	TPSAB1 TPSB2	3.44e-06	2	65	2	15567416
Pubmed	Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft.	TPSAB1 TPSB2	3.44e-06	2	65	2	10391906
Pubmed	The human mast cell tryptase tetramer: a fascinating riddle solved by structure.	TPSAB1 TPSB2	3.44e-06	2	65	2	10708850
Pubmed	Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.	TPSAB1 TPSB2	3.44e-06	2	65	2	17449330
Pubmed	Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.	TPSAB1 TPSB2	3.44e-06	2	65	2	31337736
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 TMPRSS5 CATSPERG USP17L8 TBX5	4.44e-06	674	65	9	37196079
Pubmed	Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer.	PTPN6 NTRK1	1.03e-05	3	65	2	23948750
Pubmed	Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice.	RAG2 IL23A	1.03e-05	3	65	2	22089030
Pubmed	Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.	TPSAB1 TPSB2	1.03e-05	3	65	2	9920877
Pubmed	Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.	PTPN6 NTRK1	1.03e-05	3	65	2	19749791
Pubmed	Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.	TPSAB1 TPSB2	1.03e-05	3	65	2	19748655
Pubmed	Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5.	PXN NUDT16L1	2.06e-05	4	65	2	11805099
Pubmed	CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells.	RAG2 IL23A	2.06e-05	4	65	2	22355103
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SULF2 USP17L1 KDM5A BMS1 MIOS RCC1 NUDT16L1 SEC31A CATSPERG TRRAP	3.09e-05	1082	65	10	38697112
Pubmed	TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.	PTPN6 NTRK1	3.43e-05	5	65	2	29715200
Pubmed	A THEMIS:SHP1 complex promotes T-cell survival.	RAG2 PTPN6	3.43e-05	5	65	2	25535246
Pubmed	Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families.	TPSAB1 TPSB2	3.43e-05	5	65	2	10843716
Pubmed	The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.	RAG2 PTPN6	3.43e-05	5	65	2	27548433
Pubmed	IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.	RAG2 IL23A	5.13e-05	6	65	2	20083652
Pubmed	New developments in the genetics and activation of mast cell proteases.	TPSAB1 TPSB2	5.13e-05	6	65	2	12217407
Pubmed	Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.	RAG2 PTPN6	5.13e-05	6	65	2	19647226
Pubmed	Deubiquitinating enzyme USP9X regulates metastasis and chemoresistance in triple-negative breast cancer by stabilizing Snail1.	USP17L2 PSMD14	5.13e-05	6	65	2	35506169
Pubmed	IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization.	RAG2 IL23A	5.13e-05	6	65	2	23319736
Pubmed	Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures.	ADAMTS20 HEPH	5.13e-05	6	65	2	2289471
Pubmed	Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.	RAG2 IL23A	7.18e-05	7	65	2	34433045
Pubmed	Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.	RAG2 PTPN6	7.18e-05	7	65	2	25769611
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPN6 NTRK1 PXN	9.53e-05	47	65	3	19167335
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM64B TRIM64 TRIM64C	1.52e-04	55	65	3	19468303
Pubmed	The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.	NUP37 SEC31A	1.53e-04	10	65	2	15146057
Pubmed	Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.	PTPN6 NTRK1	1.87e-04	11	65	2	21364532
Pubmed	The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.	RAG2 PTPN6	2.24e-04	12	65	2	31204070
Pubmed	Murine models of Pneumocystis infection recapitulate human primary immune disorders.	RAG2 IL23A	2.65e-04	13	65	2	29925696
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS19 ADAMTS20 ISM2	3.82e-04	75	65	3	20637190
Pubmed	Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.	RAG2 IL23A	4.06e-04	16	65	2	32632165
Pubmed	A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.	RAG2 ADGRE1	4.59e-04	17	65	2	28634350
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	TRIM64B TRIM64 TRIM64C	4.62e-04	80	65	3	16554811
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM64B TRIM64	5.76e-04	19	65	2	22144910
Pubmed	ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.	RCC1 TRRAP	6.39e-04	20	65	2	16407974
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	SULF2 NTRK1 TRRAP	9.64e-04	103	65	3	22623531
Pubmed	Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.	TPSAB1 ADGRE1	1.00e-03	25	65	2	36458554
Pubmed	Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.	RAG2 ADGRE1	1.09e-03	26	65	2	20978081
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	SEC31A TRRAP	1.26e-03	28	65	2	29653964
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	PXN TBX5	1.26e-03	28	65	2	27256596
Pubmed	Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis.	RAG2 IL23A	1.54e-03	31	65	2	31132747
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	ADAMTS19 TBX5	1.65e-03	32	65	2	31434798
Cytoband	8p23.1	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	9.06e-08	154	65	6	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.06e-06	234	65	6	chr8p23
Cytoband	11q14.3	TRIM64B TRIM64	9.53e-04	32	65	2	11q14.3
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS19 ADAMTS20	8.37e-04	19	41	2	50
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM64B TRIM64 TRIM64C	1.30e-03	95	41	3	59
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 KLK9 USP17L8	1.09e-08	112	64	7	MM1095
Coexpression	MADAN_DPPA4_TARGETS	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	6.73e-08	86	64	6	MM1312
Coexpression	GERY_CEBP_TARGETS	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	2.64e-06	160	64	6	MM1155
ToppCell	wk_15-18-Hematologic-Myeloid-Eosinophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 PTPN6 NTRK1 HYAL3 ADGRE1 TPSB2	2.03e-07	173	65	6	a85cead231e03945fabbc7762540ad21fe4299df
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 PTPN6 NTRK1 HYAL3 TPSB2	5.44e-06	173	65	5	1e4afa020fae682521335b440ccd33c16f37156f
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 PTPN6 NTRK1 HYAL3 TPSB2	5.59e-06	174	65	5	36080fa12497faa752ff07ae52cd3864053eafef
ToppCell	10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 HYAL3 TPSB2	6.42e-06	179	65	5	810972561d1ae5a68389b54ceeac7a49890513a4
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 HYAL3 TPSB2	7.33e-06	184	65	5	ce31684772e47a294155f368e50b49753f7c8e87
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 PTPN6 NTRK1 HYAL3 TPSB2	9.96e-06	196	65	5	ef481eb306350311207f7a29fdfa1ae3feaba4d7
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|hematopoetic_progenitors / Lineage and Cell class	TPSAB1 PTPN6 NTRK1 HYAL3 TPSB2	1.02e-05	197	65	5	6172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCell	10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 HYAL3 TPSB2	1.02e-05	197	65	5	5e4a004052b8560223673a339d4a0d729e533def
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 HYAL3 TPSB2	1.05e-05	198	65	5	2e6630eab77b12a6059682ab5ba465f38e469102
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSAB1 NTRK1 HYAL3 CUL9 TPSB2	1.07e-05	199	65	5	6e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSAB1 NTRK1 HYAL3 CUL9 TPSB2	1.07e-05	199	65	5	5f499595597c10857bba8272f62afe4d32d733ac
ToppCell	TCGA-Brain-Recurrent_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	USP17L7 USP17L2 USP17L3 TRIM64C	1.64e-05	104	65	4	1360c9fcb9a68b385aa28dabd0715e71c4867a5b
ToppCell	LA-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	CYP8B1 DGKD TSKS TPSB2	5.10e-05	139	65	4	9e2a84d5ed7232b70eadbba754d9ca13f2d50fe9
ToppCell	facs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBSPON ADAMTS20 TMPRSS5 CATSPERG	5.25e-05	140	65	4	115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCell	facs-Thymus-nan-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBSPON ADAMTS20 TMPRSS5 CATSPERG	5.25e-05	140	65	4	22d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCell	facs-Thymus-nan-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBSPON ADAMTS20 TMPRSS5 CATSPERG	5.25e-05	140	65	4	62d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte-granulocyte_l26\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPSAB1 LOXHD1 AGXT TPSB2	7.99e-05	156	65	4	da5cfa8fa9595613f04ce9511f8b42bad34d995a
ToppCell	Adult-Immune-mast_cell-D231\|Adult / Lineage, Cell type, age group and donor	SPC24 TPSAB1 TPSB2 TAFAZZIN	8.19e-05	157	65	4	4c63bb91f8708644e6ce2500072a4eeb8e1079dd
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SBSPON ALDH1B1 HEPH TBX5	8.60e-05	159	65	4	7cda111bb98f1241989e49d490bdf51a712ea589
ToppCell	BL-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TPSAB1 SULF2 NTRK1 DGKD	9.24e-05	162	65	4	25ec9df914445b4daae4fd28fd0e60b64797c46d
ToppCell	mild-Myeloid-Eosinophils\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NTRK1 ISM2 ADGRE1 TPSB2	9.46e-05	163	65	4	7c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCell	PND01-03-samps-Myeloid-Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PTPN6 SULF2 PPT2 ADGRE1	9.69e-05	164	65	4	49733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell	10x5'-lymph-node_spleen-Mast-Mast_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSAB1 NTRK1 HYAL3 TPSB2	1.06e-04	168	65	4	650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell	10x5'-lymph-node_spleen-Mast\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSAB1 NTRK1 HYAL3 TPSB2	1.06e-04	168	65	4	e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.09e-04	169	65	4	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	wk_20-22-Hematologic-Myeloid-Eosinophil\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 NTRK1 HYAL3 TPSB2	1.14e-04	171	65	4	fa6e856e62b82ec4972e0098e73f237cc611891f
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TPSAB1 NTRK1 ADGRE1 TPSB2	1.14e-04	171	65	4	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	TPSAB1 ZNF141 NTRK1 TPSB2	1.16e-04	172	65	4	c477008444d2d71071177807870d7455e90c2fad
ToppCell	wk_15-18-Hematologic-Myeloid-Mast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 NTRK1 HYAL3 TPSB2	1.16e-04	172	65	4	a7146c255031207e64682ef767884b11c96e0d59
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 NTRK1 HYAL3 TPSB2	1.16e-04	172	65	4	2ab720a4c96073339a1f8b95ec7699682df98acf
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 NTRK1 TSKS TPSB2	1.19e-04	173	65	4	b9dc42d629d13e63aada5ae49ba0cbb0952c5fe9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TPSAB1 NBEAL1 NTRK1 TPSB2	1.19e-04	173	65	4	3a39c7f290a9914fcf747e6bc6f13a509413b33c
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.22e-04	174	65	4	64d13a7a9757e85f4f4af876c687dd18a7efa01a
ToppCell	3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSAB1 NTRK1 DDX43 TPSB2	1.30e-04	177	65	4	53040dbeb18574a48e352e4bce252c7c3018762c
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HYAL3 JMJD4 DGKD HEPH	1.33e-04	178	65	4	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	TPSAB1 NTRK1 HYAL3 TPSB2	1.39e-04	180	65	4	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 PTPN6 ADGRE1 TPSB2	1.39e-04	180	65	4	1c5515f29ead129bee3b4ca27799796956811a39
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	TPSAB1 NTRK1 HYAL3 TPSB2	1.42e-04	181	65	4	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPC24 RAG2 NUP37 RCC1	1.42e-04	181	65	4	a9f1fc5973cffdbeb7d1f5c41534422d85d596ff
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPC24 RAG2 NUP37 RCC1	1.42e-04	181	65	4	145fae2746c5212640b7b11b04a7759ba8e5c322
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|World / Lineage and Cell class	TPSAB1 NTRK1 HYAL3 TPSB2	1.45e-04	182	65	4	a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPC24 RCC1 DDX43 TSKS	1.48e-04	183	65	4	769a022fe8568ec49e66f792cc5777e713a7571c
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPC24 RCC1 DDX43 TSKS	1.48e-04	183	65	4	aac0695fafa59cabd920ee18b1139d3e00d898e8
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ADAMTS19 SULF2 ALDH1B1 ISM2	1.51e-04	184	65	4	39168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCell	droplet-Marrow-BM-1m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPC24 SULF2 NUP37 ALDH1B1	1.60e-04	187	65	4	028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SBSPON ALDH1B1 HEPH TBX5	1.64e-04	188	65	4	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBSPON PCDH11X KLK9 TMPRSS5	1.64e-04	188	65	4	3b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 ADGRE1 TPSB2	1.64e-04	188	65	4	b4d695c373195d389e0a579e9589e87433286b24
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBSPON PCDH11X KLK9 TMPRSS5	1.64e-04	188	65	4	c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 PTPN6 NTRK1 TPSB2	1.64e-04	188	65	4	ab95a97db1a84bf3e53a4616a83ee81a6ce5ec12
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|World / Lineage and Cell class	TPSAB1 NTRK1 HYAL3 TPSB2	1.74e-04	191	65	4	91327184ca40bfb8c9e904991b1be503aaccd7bc
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 PTPN6 NTRK1 TPSB2	1.74e-04	191	65	4	14b11244c330cc4fe897253aaaf0df80caa01a55
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|hematopoetic_progenitors / Lineage and Cell class	TPSAB1 NTRK1 HYAL3 TPSB2	1.74e-04	191	65	4	3b061dbc10918be7cbbd4453311d2c1ebf18c6b2
ToppCell	10x5'-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	PTPN6 SULF2 ADGRE1 ZDHHC1	1.74e-04	191	65	4	a862a571625ab7238589ff201e5954f602c3bd7e
ToppCell	PCW_10-12-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 PTPN6 NTRK1 TPSB2	1.74e-04	191	65	4	47f20686001f945bc31d5a0b974958e4009edb34
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 TPSB2	1.78e-04	192	65	4	9ad9dce4fcbb133b135079eb4cc32c7ead7f0243
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HYAL3 PCDH11X TSKS TBX5	1.81e-04	193	65	4	e5016959f24370579a8770787e96869f264cf7b3
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.85e-04	194	65	4	d8f367beab16a3186821e42311947b6c9e99978c
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|World / Lineage, cell class and subclass	TPSAB1 HYAL3 ALDH1B1 TPSB2	1.85e-04	194	65	4	f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ToppCell	3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 PTPN6 NTRK1 TPSB2	1.85e-04	194	65	4	a85e98af9dc9a4f0437be3700d63a6d21415199b
ToppCell	erythropoietic-CD34+_Pro-erythroblast\|erythropoietic / Lineage and Cell class	TPSAB1 PTPN6 HYAL3 TPSB2	1.88e-04	195	65	4	cd3d8fa6e18c0508cdfb64bb879d90b211badee5
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.88e-04	195	65	4	fbedb9978ded857fd35c2a8664f7579f42edaa36
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.88e-04	195	65	4	f1f48e2e57b2282572959b152aad4bee05143f03
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRIM64B TPSAB1 NTRK1 HYAL3	1.92e-04	196	65	4	5bb8653af62334ded8aad48b24b64d7b54bc3cd5
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	1.92e-04	196	65	4	e08f90f7a923c2846cac859519b8dc7c0ac7cd03
ToppCell	Caecum-T_cell-Tfh\|T_cell / Region, Cell class and subclass	SPC24 SEC31A ADGRE1 ZDHHC1	1.92e-04	196	65	4	fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	THAP8 KLK9 TMPRSS5	1.95e-04	77	65	3	4d6e2486dd7702c4e0115567dd0a2c16617816aa
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	THAP8 KLK9 TMPRSS5	1.95e-04	77	65	3	ddd54a5ef6a1fc8be1e852c2192204a749b819c1
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TPSAB1 NTRK1 HYAL3 TPSB2	1.96e-04	197	65	4	7619924615a43011b4a86efbe6e7e5445f96722b
ToppCell	distal-3-mesenchymal-Fibromyocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SBSPON PCDH11X ALDH1B1 TBX5	2.00e-04	198	65	4	dc93886439a378a0c71e99acb8081bfb6b6d467b
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	2.04e-04	199	65	4	a24a319d3ba8f4759f742af27610b4d62e359a2d
ToppCell	mLN-(7)_Mast_cell-(70)_Mast\|mLN / shred on region, Cell_type, and subtype	TPSAB1 NTRK1 ZDHHC1 TPSB2	2.08e-04	200	65	4	a6c258cae678be581b1d85cf3446c65c34b13499
ToppCell	mLN-Mast_cell-Mast\|mLN / Region, Cell class and subclass	TPSAB1 NTRK1 ZDHHC1 TPSB2	2.08e-04	200	65	4	81ea6e7a3940277751faf9097b30198159998c7b
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 NTRK1 HYAL3 TPSB2	2.08e-04	200	65	4	cad2d972aa6ea0cc9ebe5ec60fda6e306e9ee2b2
ToppCell	mLN-Mast_cell\|mLN / Region, Cell class and subclass	TPSAB1 NTRK1 ZDHHC1 TPSB2	2.08e-04	200	65	4	9a5f1d99d8d160923d4d0fbbf9ad48a26f8a4fad
ToppCell	mLN-(7)_Mast_cell\|mLN / shred on region, Cell_type, and subtype	TPSAB1 NTRK1 ZDHHC1 TPSB2	2.08e-04	200	65	4	13bca944fbdbc0be6687eca82c62a4d231ab94f0
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SPC24 HYAL3 CATSPERG	2.35e-04	82	65	3	01a4d47d9e0dee68a5277ed1534338cec80f75d1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SPC24 HYAL3 CATSPERG	2.35e-04	82	65	3	c1489097c291f413f3cfa5e26f8182ec872328fd
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	5.32e-10	46	61	6	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	6.57e-09	69	61	6	DOID:1682 (implicated_via_orthology)
Disease	tryptase beta-2 measurement	TPSAB1 TPSB2	1.50e-04	9	61	2	EFO_0008306
Disease	urticaria	TPSAB1 TPSB2	7.80e-04	20	61	2	EFO_0005531
Disease	Ovarian Serous Adenocarcinoma	NTRK1 TRRAP	1.03e-03	23	61	2	C1335177
Disease	Adenocarcinoma of large intestine	PMS2 NTRK1 TRRAP	1.05e-03	96	61	3	C1319315
Disease	Ovarian Mucinous Adenocarcinoma	MAST2 TRRAP	1.88e-03	31	61	2	C1335167
Disease	Inherited neuropathies	NTRK1 SPG11	3.12e-03	40	61	2	C0598589

Protein segments in the cluster

Peptide	Gene	Start	Entry
FHIMSHESPGIEWLC	CATSPERG	996	Q6ZRH7
VHHVTGMWVYPFLEH	AIG1	176	Q9NVV5
WHGKTIPMDGQHFCF	ALDH1B1	156	P30837
YTPQHMHCGAAFWGP	BMS1	971	Q14692
HMHACPADVSWHQEP	ADAMTS20	1411	P59510
CDSLWHNITVVHMPG	NBEAL1	661	Q6ZS30
PAMIYCSHGDGHWVH	RAG2	441	P55895
WVGFSGGQHHTVCMD	RCC1	296	P18754
GLYPHHTEHGRCMAW	RFX6	716	Q8HWS3
HPSCADGLHIMSGEW	ADAMTS19	496	Q8TE59
MHHWCIPFSVDGQPA	NTRK1	296	P04629
NTGMNPGWHCSHVDI	LOXHD1	1176	Q8IVV2
HQHGCWTVTEPAAMT	ISM2	76	Q6H9L7
HFVLHSPGMSVCWHP	NUP37	161	Q8NFH4
YGHSDACWMPASLDH	PCDH11X	1146	Q9BZA7
VVTHMWTAPSFCAEH	KDM5A	1386	P29375
TAMGKTWHPEHFVCT	PXN	371	P49023
CPMAGISHTAWHSNR	PPT2	276	Q9UMR5
HESPSQPHMCGWEDS	GUCA1ANB	6	X6R8D5
QEAGEMVFVPSGWHH	JMJD4	301	Q9H9V9
HYPACGNGWHSMASN	HYAL3	201	O43820
CTLAWSAHPLVGHMD	IL23A	41	Q9NPF7
YTVHHMVWHVEDGGP	MAST2	1131	Q6P0Q8
SGMHNWYACSHARPT	DGKD	161	Q16760
HWAYPGHISDSMLCA	KLK9	176	Q9UKQ9
EAHYPASCGHMSQWV	CUL9	2196	Q8IWT3
MSHHGGAPKASTWVV	DDX43	1	Q9NXZ2
IHHYTMPWGSGVSIC	CYP8B1	426	Q9UNU6
EMVVGWYHSHPGFGC	PSMD14	106	O00487
CGHCPGTWDSAHVHV	RTP5	56	Q14D33
WGCDDQPRMYHHTIP	AGXT	251	P21549
HGPYWMHFCGGSLIH	TPSAB1	51	Q15661
HGPYWMHFCGGSLIH	TPSB2	51	P20231
LQHMGCEHWVPSCHQ	THAP8	41	Q8NA92
QYHSVHGVGMVPEWS	TBX5	501	Q99593
ASNPGTWLMHCHVTD	HEPH	1036	Q9BQS7
GCCVMHSWEGHIRPT	ADGRE1	11	Q14246
AHVACEHPTGWSSME	SPG11	1756	Q96JI7
CTMQAHITWALHSPG	USP17L3	126	A6NCW0
CTMQAHITWALHSPG	USP17L4	126	A6NCW7
AGHMLSWFRDHAECP	MIOS	836	Q9NXC5
SPHWSTHTEDAGYCM	SBSPON	156	Q8IVN8
VSNHQSCMDDPHLWG	TAFAZZIN	66	Q16635
WDYECEPGMVKGIHH	SPC24	151	Q8NBT2
EAMRLGPGWSHSCHA	NUDT16L1	16	Q9BRJ7
GPGWSHSCHAMLYAA	NUDT16L1	21	Q9BRJ7
LCHMEPANHFWHAGD	PSORS1C1	46	Q9UIG5
GWGHTHPSHTYSSDM	TMPRSS5	346	Q9H3S3
TGSCGHVMHAVCWQK	UBR1	1156	Q8IWV7
HGVEPQMSHQPMHWC	TSKS	56	Q9UJT2
CTMQAHITWALHSPG	USP17L1	126	Q7RTZ2
ITHMGEMDHPWNCPH	PMS2	831	P54278
NCSDPTSERWYHGHM	PTPN6	101	P29350
AMCSHFTQDHWPVQG	ZNF141	76	Q15928
CTMQAHITWALHSPG	USP17L7	126	P0C7H9
CTMQAHITWALHSPG	USP17L8	126	P0C7I0
RCDPSSGHMFVHWYR	TRBV17	41	A0A087X0K7
MAHSHSPIGWAAEEC	TRIM64C	121	A6NLI5
MAHSHSPIGWAAEEC	TRIM64	121	A6NGJ6
CDHVPSTLHIMWAGQ	VRTN	211	Q9H8Y1
SNRMHCSGLAWHPDV	SEC31A	211	O94979
MAHSHSPIGWAAEEC	TRIM64B	121	A6NI03
QHHYQGKPTWSGMHS	TRRAP	2996	Q9Y4A5
SMPGLTCFTHDNQHW	SULF2	721	Q8IWU5
CTMQAHITWALHSPG	USP17L2	126	Q6R6M4
HHWVPAGYACMGAIF	ZDHHC1	76	Q8WTX9
KGLSSHMCFHSDQWP	ZNF541	851	Q9H0D2