Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	nodal receptor complex assembly	LEFTY2 LEFTY1	4.00e-05	2	131	2	GO:0038099
GeneOntologyBiologicalProcess	negative regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.00e-05	2	131	2	GO:1900124
GeneOntologyBiologicalProcess	regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.00e-05	2	131	2	GO:1900123
GeneOntologyBiologicalProcess	neuron development	SALL3 HECW1 HTRA2 INPPL1 ITSN1 NCKIPSD SCYL1 PCDHAC2 PTK2 LRP8 GRIP1 BMPR1B LLGL1 CELSR3 UGDH CD44 LRP1 LRP4 ROBO1 CTNNB1 CDH1 EP300 TBCD	4.57e-05	1463	131	23	GO:0048666
GeneOntologyCellularComponent	intercalated disc	ANK2 PTK2 SLC8A1 SCN5A CTNNB1	8.12e-05	68	136	5	GO:0014704
GeneOntologyCellularComponent	basal plasma membrane	ANK2 INPPL1 PTK2 SLC8A1 LLGL1 PROM2 CD44 LRP1 CTNNB1 CDH1	1.10e-04	354	136	10	GO:0009925
GeneOntologyCellularComponent	cyclin D2-CDK4 complex	CCND2 CDK4	1.26e-04	3	136	2	GO:0097129
GeneOntologyCellularComponent	lamellipodium	INPPL1 ITSN1 DYSF PTK2 SYNE2 CD44 CTNNB1 CDH1	1.34e-04	230	136	8	GO:0030027
GeneOntologyCellularComponent	basal part of cell	ANK2 INPPL1 PTK2 SLC8A1 LLGL1 PROM2 CD44 LRP1 CTNNB1 CDH1	1.87e-04	378	136	10	GO:0045178
GeneOntologyCellularComponent	basolateral plasma membrane	ANK2 PTK2 SLC8A1 LLGL1 PROM2 CD44 LRP1 CTNNB1 CDH1	2.52e-04	320	136	9	GO:0016323
GeneOntologyCellularComponent	cell-cell contact zone	ANK2 PTK2 SLC8A1 SCN5A CTNNB1	3.74e-04	94	136	5	GO:0044291
GeneOntologyCellularComponent	Z disc	ANK2 SLC8A1 PDLIM3 SYNE2 SCN5A CTNNB1	4.67e-04	151	136	6	GO:0030018
GeneOntologyCellularComponent	membrane microdomain	DYSF LRP8 GRIP1 PROM2 SCN5A CD44 LRP4 CTNNB1 CDH1	6.41e-04	364	136	9	GO:0098857
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CCNY CCND2 BRD4 CDK4	6.71e-04	61	136	4	GO:0000307
GeneOntologyCellularComponent	I band	ANK2 SLC8A1 PDLIM3 SYNE2 SCN5A CTNNB1	7.69e-04	166	136	6	GO:0031674
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	POLR2A DAPK1 TRRAP CCNY CCND2 BRD4 POLG2 CDK4	1.60e-03	335	136	8	GO:0061695
GeneOntologyCellularComponent	anchoring junction	STARD8 ANK2 ARHGEF5 PTK2 SLC8A1 LLGL1 PDLIM3 SYNE2 SCN5A CD44 LRP1 CTNNB1 CDH1 TBCD CDK4	1.74e-03	976	136	15	GO:0070161
GeneOntologyCellularComponent	T-tubule	ANK2 DYSF SLC8A1 SCN5A	1.77e-03	79	136	4	GO:0030315
GeneOntologyCellularComponent	flotillin complex	CTNNB1 CDH1	1.83e-03	10	136	2	GO:0016600
HumanPheno	Subglottic stenosis	FRAS1 GRIP1 TONSL ROBO1	1.16e-05	17	45	4	HP:0001607
Domain	LRDF	LEFTY2 LEFTY1	5.03e-05	2	133	2	IPR003942
Domain	Ldl_recept_b	LRP8 LRP1 LRP4	1.21e-04	14	133	3	PF00058
Domain	LDLRB	LRP8 LRP1 LRP4	1.21e-04	14	133	3	PS51120
Domain	LY	LRP8 LRP1 LRP4	1.51e-04	15	133	3	SM00135
Domain	LDLR_classB_rpt	LRP8 LRP1 LRP4	1.51e-04	15	133	3	IPR000033
Domain	Peptidase_S1C	HTRA2 HTRA3	2.99e-04	4	133	2	IPR001940
Domain	PDZ_2	HTRA2 HTRA3	2.99e-04	4	133	2	PF13180
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	ANK2 INPPL1 ITSN1 NCKIPSD TMPRSS5 DENND1C ACOX3 LRP8 ESYT2 CSNK1G2 LRP1 LRP4	1.28e-05	381	98	12	M48063
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	CCND2 PTPA NKD1 CD44 CTNNB1 EP300	7.20e-05	101	98	6	M39387
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	CCND2 PTPA NKD1 CD44 CTNNB1 EP300	7.20e-05	101	98	6	MM15829
Pathway	BIOCARTA_PITX2_PATHWAY	TRRAP CTNNB1 EP300	1.40e-04	15	98	3	MM1439
Pathway	KEGG_MEDICUS_REFERENCE_P300_P21_CELL_CYCLE_G1_S	CCND2 EP300 CDK4	1.40e-04	15	98	3	M47524
Pathway	WP_OVARIAN_INFERTILITY	CCND2 BMPR1B SYNE2 CDK4	1.50e-04	39	98	4	M39458
Pathway	WP_H19_RBE2F1_AND_CDKBETACATENIN_IN_COLORECTAL_CANCER	CTNNB1 CDH1 CDK4	1.71e-04	16	98	3	M39472
Pathway	BIOCARTA_PITX2_PATHWAY	TRRAP CTNNB1 EP300	1.71e-04	16	98	3	M8516
Pathway	PID_BETA_CATENIN_NUC_PATHWAY	TRRAP CCND2 CTNNB1 CDH1 EP300	2.33e-04	80	98	5	M223
Pathway	PID_FOXO_PATHWAY	RAN CSNK1G2 CTNNB1 EP300	3.66e-04	49	98	4	M136
Pathway	WP_TROP2_REGULATORY_SIGNALING	PTK2 CTNNB1 CDH1 CDK4	3.66e-04	49	98	4	M46458
Pathway	REACTOME_DRUG_MEDIATED_INHIBITION_OF_CDK4_CDK6_ACTIVITY	CCND2 CDK4	4.72e-04	5	98	2	M45016
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CTNNB1 EP300	4.72e-04	5	98	2	M27228
Pathway	REACTOME_DRUG_MEDIATED_INHIBITION_OF_CDK4_CDK6_ACTIVITY	CCND2 CDK4	4.72e-04	5	98	2	MM15696
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING	LEFTY2 LEFTY1 CTNNB1 EP300	5.71e-04	55	98	4	M39351
Pathway	REACTOME_GLUCURONIDATION	UGT2A3 UGT2A1 UGDH	5.93e-04	24	98	3	MM14599
Pathway	REACTOME_GLUCURONIDATION	UGT2A3 UGT2A1 UGDH	6.71e-04	25	98	3	M17787
Pathway	WP_GLUCURONIDATION	UGT2A3 UGT2A1 UGDH	6.71e-04	25	98	3	MM15820
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2A3 UGT2A1 UGDH	6.71e-04	25	98	3	M605
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	LEFTY2 LEFTY1 CTNNB1 EP300	7.46e-04	59	98	4	M39886
Pathway	WP_GLUCURONIDATION	UGT2A3 UGT2A1 UGDH	7.54e-04	26	98	3	M39404
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	TRRAP CTNNB1 EP300	7.54e-04	26	98	3	MM14793
Pathway	WP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM	FRAS1 GRIP1 ROBO1 CTNNB1	7.95e-04	60	98	4	M40048
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FRAS1 B4GALNT4 RAPGEF6 VWA8 INPPL1 POLR2A DYSF TRRAP HDAC7 ACOX3 CELSR3 SBF1 PROM2 CSNK1G2 BRD4 SCN5A LRP4 DEPDC5 EP300 TBCD	1.43e-08	1105	137	20	35748872
Pubmed	Differential immunohistochemical expression of CD44s, E-cadherin and β-catenin among hyperplastic and neoplastic lesions of the prostate gland.	CD44 CTNNB1 CDH1	5.98e-08	3	137	3	23220849
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RAPGEF6 ARHGEF5 INPPL1 ITSN1 SCYL1 PTK2 USF3 BNIP3L NUP155 TONSL INAVA MGA	1.51e-07	430	137	12	35044719
Pubmed	Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells.	LEFTY2 LEFTY1 CTNNB1	2.38e-07	4	137	3	23592333
Pubmed	p68/DdX5 supports β-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.	POLR2A DDX5 CTNNB1	2.38e-07	4	137	3	23349811
Pubmed	Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.	POLR2A DDX5 EP300	2.38e-07	4	137	3	12527917
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 RAPGEF6 ARHGEF5 DPM1 PTK2 TMEM177 LLGL1 NUP155 SBF1 TONSL UGDH XRN1 CARD6 AP4B1	3.17e-07	650	137	14	38777146
Pubmed	Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.	LEFTY2 LEFTY1 CTNNB1 CDH1	4.04e-07	16	137	4	16256739
Pubmed	Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation.	PTK2 CDH1 CDK4	5.95e-07	5	137	3	35525274
Pubmed	Calpain induces N-terminal truncation of β-catenin in normal murine liver development: diagnostic implications in hepatoblastomas.	PTK2 CTNNB1 CDH1	5.95e-07	5	137	3	22613727
Pubmed	Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model.	HDAC7 EP300 CDK4	5.95e-07	5	137	3	23880157
Pubmed	Tcf3: a transcriptional regulator of axis induction in the early embryo.	LEFTY2 LEFTY1 CTNNB1 CDH1	6.75e-07	18	137	4	14668413
Pubmed	Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.	CCND2 CTNNB1 CDH1 CDK4	8.53e-07	19	137	4	17596282
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	RAPGEF6 INPPL1 CCNY LRP8 GRIP1 ESYT2 LLGL1 NUP155 SBF1 ROBO1 CTNNB1	9.71e-07	421	137	11	36976175
Pubmed	Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription.	GRIP1 CTNNB1 EP300	1.19e-06	6	137	3	16990252
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	LEFTY2 LEFTY1 NKD1 CTNNB1	1.31e-06	21	137	4	16291790
Pubmed	Disruption of early proximodistal patterning and AVE formation in Apc mutants.	LEFTY2 LEFTY1 CTNNB1 CDH1	1.93e-06	23	137	4	16887818
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ANK2 DAPK1 ATP10D CCNY LRP8 BLMH ESYT2 LLGL1 PROM2 CSNK1G2 CD44 CTNNB1	2.85e-06	569	137	12	30639242
Pubmed	Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos.	CCND2 CTNNB1 CDH1	3.30e-06	8	137	3	29445069
Pubmed	APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.	LRP8 LRP1 LRP4	4.94e-06	9	137	3	23986861
Pubmed	Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline.	LEFTY2 LEFTY1 CDH1	4.94e-06	9	137	3	20678497
Pubmed	Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.	PTK2 CTNNB1 CDH1	4.94e-06	9	137	3	19820184
Pubmed	N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.	BMPR1B CD44 CTNNB1 CDH1	5.83e-06	30	137	4	20534673
Pubmed	Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.	TRRAP DDX5 EP300	7.03e-06	10	137	3	12738788
Pubmed	Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.	PTK2 CTNNB1 CDH1	7.03e-06	10	137	3	11113628
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	ZBTB47 NLRP1 BRD4 UGDH CTNNB1 CDH1 EP300 CDK4	8.77e-06	257	137	8	30945288
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	EPHX1 RAN INPPL1 POLR2A ADAR DPM1 ESYT2 NUP155 UGDH XRN1 CTNNB1	9.37e-06	534	137	11	35032548
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	EPHX1 VWA8 POLR2A SCYL1 TRRAP DDX5 SYNE2 UGT2A1 UGDH CD44 MGA EP300 PCID2	9.59e-06	754	137	13	35906200
Pubmed	Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.	LRP4 CTNNB1 CDH1	9.64e-06	11	137	3	20454682
Pubmed	Role of LGR5-positive mesenchymal cells in craniofacial development.	NKD1 CTNNB1 CDH1	9.64e-06	11	137	3	36133922
Pubmed	β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development.	CD44 CTNNB1 CDH1	9.64e-06	11	137	3	37639482
Pubmed	Genomic analysis of mouse retinal development.	DDAH1 SALL3 POLR2A ADAR PTK2 LRP8 CCND2 BNIP3L NKD1 BRD4 TONSL ROBO1 CTNNB1 PCID2 CDK4	1.09e-05	1006	137	15	15226823
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RAN FRAS1 POLR2A SCYL1 ADAR DPM1 DDX5 ESYT2 CTNNB1 CPSF3 EP300 DNPEP	1.14e-05	653	137	12	33742100
Pubmed	Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.	CCND2 CTNNB1 CDH1 CDK4	1.23e-05	36	137	4	32703236
Pubmed	Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo.	LEFTY2 LEFTY1 CDH1	1.28e-05	12	137	3	22342906
Pubmed	The loop-tail mouse model displays open and closed caudal neural tube defects.	CD44 CTNNB1 CDH1	1.28e-05	12	137	3	37589570
Pubmed	Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.	LEFTY2 LEFTY1 CDH1	1.28e-05	12	137	3	19706528
Pubmed	Roundabout receptors are critical for foregut separation from the body wall.	ROBO1 CTNNB1 CDH1	1.28e-05	12	137	3	23328398
Pubmed	AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression.	LEFTY2 LEFTY1 CTNNB1	1.28e-05	12	137	3	25910836
Pubmed	Influence of focal adhesion kinase on the mechanical behavior of cell populations.	PTK2 CDH1	1.54e-05	2	137	2	23726908
Pubmed	Immunoexpression of beta-catenin--E-cadherin complex in primary serous ovarian tumors.	CTNNB1 CDH1	1.54e-05	2	137	2	18655368
Pubmed	Distribution of E-cadherin and beta-catenin in relation to cell maturation and cell extrusion in rat and mouse small intestines.	CTNNB1 CDH1	1.54e-05	2	137	2	16733663
Pubmed	β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.	CTNNB1 CDH1	1.54e-05	2	137	2	24268141
Pubmed	Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.	LRP8 LRP1	1.54e-05	2	137	2	12871934
Pubmed	Study on the role of G1 cyclins in Epstein-Barr virus-associated human lymphomas maintained in severe combined immune deficiency (SCID) mice.	CCND2 CDK4	1.54e-05	2	137	2	11291051
Pubmed	Relation of E-cadherin and beta-catenin expression to pit pattern in colorectal cancer.	CTNNB1 CDH1	1.54e-05	2	137	2	15289833
Pubmed	Exchange of catenins in cadherin-catenin complex.	CTNNB1 CDH1	1.54e-05	2	137	2	12606944
Pubmed	[Leukemia cell surface expression of E-cadherin and its correlation with membrane localization of beta-catenin].	CTNNB1 CDH1	1.54e-05	2	137	2	19175984
Pubmed	[The specific features of the expression of E-cadherin and beta-catenin in adenomyosis].	CTNNB1 CDH1	1.54e-05	2	137	2	19137776
Pubmed	SHIP2 associates with intersectin and recruits it to the plasma membrane in response to EGF.	INPPL1 ITSN1	1.54e-05	2	137	2	18692052
Pubmed	Correlation between E-cadherin and CD44 adhesion molecules expression and cervical lymph node metastasis in oral tongue SCC: Predictive significance or not.	CD44 CDH1	1.54e-05	2	137	2	21632186
Pubmed	beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells.	CTNNB1 CDH1	1.54e-05	2	137	2	17909039
Pubmed	FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression.	CD44 CDH1	1.54e-05	2	137	2	30963578
Pubmed	Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.	CTNNB1 CDH1	1.54e-05	2	137	2	27600761
Pubmed	Enhanced beta-catenin expression and inflammation are associated with human ectopic tubal pregnancy.	CTNNB1 CDH1	1.54e-05	2	137	2	23787212
Pubmed	Immunohistochemical assessment of E-cadherin and β-catenin in the histological differentiations of oral squamous cell carcinoma.	CTNNB1 CDH1	1.54e-05	2	137	2	25374218
Pubmed	O-GlcNAcylation affects β-catenin and E-cadherin expression, cell motility and tumorigenicity of colorectal cancer.	CTNNB1 CDH1	1.54e-05	2	137	2	29391154
Pubmed	Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.	CTNNB1 CDH1	1.54e-05	2	137	2	23954158
Pubmed	LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.	LEFTY2 LEFTY1	1.54e-05	2	137	2	20056823
Pubmed	Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.	LEFTY2 LEFTY1	1.54e-05	2	137	2	10053005
Pubmed	Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.	LEFTY2 LEFTY1	1.54e-05	2	137	2	11100524
Pubmed	The cadherin-catenin complex in nasopharyngeal carcinoma.	CTNNB1 CDH1	1.54e-05	2	137	2	21240516
Pubmed	Alteration of the E-cadherin/β-catenin complex predicts poor response to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment.	CTNNB1 CDH1	1.54e-05	2	137	2	23579873
Pubmed	Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.	SETMAR CD44	1.54e-05	2	137	2	23964856
Pubmed	Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone.	CTNNB1 CDH1	1.54e-05	2	137	2	18008331
Pubmed	Biomarkers of epithelial-mesenchymal transition: E-cadherin and beta-catenin in malignant transformation of oral lesions.	CTNNB1 CDH1	1.54e-05	2	137	2	38974823
Pubmed	Expression of E-cadherin and β-catenin in basaloid and conventional squamous cell carcinoma of the oral cavity: are potential prognostic markers?	CTNNB1 CDH1	1.54e-05	2	137	2	24893577
Pubmed	E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis.	CD44 CDH1	1.54e-05	2	137	2	12511569
Pubmed	Expression and significance of E-cadherin and β-catenins in pituitary adenoma.	CTNNB1 CDH1	1.54e-05	2	137	2	23349466
Pubmed	Invasive meningioma is associated with a low expression of E-cadherin and beta-catenin.	CTNNB1 CDH1	1.54e-05	2	137	2	15696778
Pubmed	Profiling of E-cadherin, beta-catenin and Ca(2+) in embryo-uterine interactions at implantation.	CTNNB1 CDH1	1.54e-05	2	137	2	17011554
Pubmed	Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta-catenin-based adherens junctions.	CTNNB1 CDH1	1.54e-05	2	137	2	17429067
Pubmed	Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis.	CTNNB1 CDH1	1.54e-05	2	137	2	12219004
Pubmed	Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation.	CTNNB1 CDH1	1.54e-05	2	137	2	18332139
Pubmed	Loss of expression of E-cadherin and beta-catenin is associated with progression of pulmonary adenocarcinoma.	CTNNB1 CDH1	1.54e-05	2	137	2	15660698
Pubmed	Trans-repression of beta-catenin activity by nuclear receptors.	CTNNB1 EP300	1.54e-05	2	137	2	12972427
Pubmed	Impact of the Canonical Wnt Pathway Activation on the Pathogenesis and Prognosis of Adamantinomatous Craniopharyngiomas.	CTNNB1 CDH1	1.54e-05	2	137	2	29625497
Pubmed	Invasive Micropapillary Carcinoma of the Breast: Immunophenotypic Analysis and Role of Cell Adhesion Molecules (CD44 and E-Cadherin) in Nodal Metastasis.	CD44 CDH1	1.54e-05	2	137	2	26200840
Pubmed	CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion.	CD44 CDH1	1.54e-05	2	137	2	22069487
Pubmed	[Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells].	CTNNB1 CDH1	1.54e-05	2	137	2	12839684
Pubmed	E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance.	CTNNB1 CDH1	1.54e-05	2	137	2	17663505
Pubmed	Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis.	COL6A6 COL6A5	1.54e-05	2	137	2	22226732
Pubmed	Alterations of E-cadherin and beta-catenin in gastric cancer.	CTNNB1 CDH1	1.54e-05	2	137	2	11747475
Pubmed	Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification.	HDAC7 CTNNB1	1.54e-05	2	137	2	25389289
Pubmed	Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer.	CTNNB1 CDH1	1.54e-05	2	137	2	29879416
Pubmed	Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis.	POLR2A PTK2	1.54e-05	2	137	2	25270220
Pubmed	N-terminal nesprin-2 variants regulate β-catenin signalling.	SYNE2 CTNNB1	1.54e-05	2	137	2	27321956
Pubmed	Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide.	CTNNB1 CDH1	1.54e-05	2	137	2	33688971
Pubmed	LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.	CD44 LRP1	1.54e-05	2	137	2	22711991
Pubmed	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	LEFTY2 LEFTY1	1.54e-05	2	137	2	33409963
Pubmed	Inhibition of CD44 sensitizes cisplatin-resistance and affects Wnt/β-catenin signaling in HNSCC cells.	CD44 CTNNB1	1.54e-05	2	137	2	31953176
Pubmed	Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1.	FRAS1 GRIP1	1.54e-05	2	137	2	18155042
Pubmed	Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing β-Catenin Activity.	CTNNB1 CDH1	1.54e-05	2	137	2	30401720
Pubmed	Regulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes.	CCND2 CDK4	1.54e-05	2	137	2	8543804
Pubmed	Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.	LEFTY2 LEFTY1	1.54e-05	2	137	2	17038673
Pubmed	Nuclear translocation of β-catenin induced by E-cadherin endocytosis causes recurrent erosion of diabetic cornea.	CTNNB1 CDH1	1.54e-05	2	137	2	33554651
Pubmed	Expression of the collagen VI α5 and α6 chains in normal human skin and in skin of patients with collagen VI-related myopathies.	COL6A6 COL6A5	1.54e-05	2	137	2	20882040
Pubmed	Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor.	CCND2 CDK4	1.54e-05	2	137	2	15797629
Pubmed	Usefulness and limitations of E-cadherin and β-catenin in the classification of breast carcinomas in situ with mixed pattern.	CTNNB1 CDH1	1.54e-05	2	137	2	23837653
Pubmed	Association of Genetic Polymorphisms in CDH1 and CTNNB1 with Breast Cancer Susceptibility and Patients' Prognosis among Chinese Han Women.	CTNNB1 CDH1	1.54e-05	2	137	2	26285011
Interaction	EPHA2 interactions	RAPGEF6 ARHGEF5 INPPL1 CYP2S1 PTK2 CCNY LRP8 CCND2 GRIP1 ESYT2 LLGL1 NUP155 SBF1 CSNK1G2 CD44 ROBO1 CTNNB1 CDH1 CDK4	2.62e-07	719	133	19	int:EPHA2
Cytoband	1q42.1	EPHX1 LEFTY2 LEFTY1	5.61e-06	12	137	3	1q42.1
Cytoband	3p21	NCKIPSD SCN5A CTNNB1	1.33e-04	33	137	3	3p21
GeneFamily	Low density lipoprotein receptors	LRP8 LRP1 LRP4	3.18e-05	13	89	3	634
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF135 SALL3 ZBTB47 ZNF300 ZIC4 ZNF594 ZNF28 ZNF550 ZNF565 ZNF468 ZNF791	7.82e-04	718	89	11	28
GeneFamily	PDZ domain containing	RAPGEF6 HTRA2 HTRA3 GRIP1 PDLIM3	9.25e-04	152	89	5	1220
Coexpression	CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_UP	RAN FRAS1 HDAC7 PTK2 ATP10D LRP8 CCND2 BLMH YEATS2 LLGL1 NKD1 CELSR3 PGAP1 SCN5A LRP4 ROBO1 CTNNB1 CDK4	7.82e-07	891	135	18	M45033
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNA1E ANK2 DYSF ACOX3 GRIP1 SLC8A1 PDLIM3 SCN5A	1.19e-07	188	136	8	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 DAPK1 GRIP1 BMPR1B PROM2 SYNE2 INAVA FAM149A	1.58e-07	195	136	8	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 CYP2S1 BMPR1B SLC8A1 TMEM45B PROM2 CDH1	1.48e-06	182	136	7	fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCell	Myeloid-Myeloid-B_(Activated_Macrophage)\|Myeloid / shred on cell class and cell subclass (v4)	RAN CCND2 BNIP3L CD44 LRP1 CSTB CTNNB1	2.05e-06	191	136	7	7bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	CACNA1E ANK2 DYSF GRIP1 SLC8A1 PDLIM3 SCN5A	2.05e-06	191	136	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FRAS1 ANK2 COL6A6 NKD1 PDLIM3 PGAP1 ROBO1	2.05e-06	191	136	7	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FRAS1 ANK2 COL6A6 NKD1 PDLIM3 PGAP1 ROBO1	2.12e-06	192	136	7	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 ANK2 GRIP1 TMEM45B SLAIN1 CDH1 FAM149A	2.12e-06	192	136	7	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ANK2 DAPK1 SLC8A1 PROM2 PGAP1 CDH1	2.12e-06	192	136	7	6fb56d062c35617b18b927704bf5fba894faed81
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ANK2 DAPK1 SLC8A1 PROM2 PGAP1 CDH1	2.19e-06	193	136	7	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	DDAH1 SALL3 CCND2 NKD1 UGDH INAVA CDK4	2.78e-06	200	136	7	439265194cb08d1373296bf8684cc31294cecb20
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-OPC_related-OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	DDAH1 SALL3 CCND2 NKD1 UGDH INAVA CDK4	2.78e-06	200	136	7	0450a79c5fae5ccacdb990ae674e4734ef0c3691
ToppCell	facs-Large_Intestine-Proximal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDAH1 ADCK5 SLC8A1 UGDH CD44 LRP1	1.30e-05	168	136	6	23e0e1592d7400012d289adb10c7598285bae2e9
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	SETMAR HMBS GRIP1 LLGL1 TONSL DEPDC5	1.30e-05	168	136	6	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF5 SLC8A1 SYNE2 UGDH CD44 LRP1	1.54e-05	173	136	6	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF5 SLC8A1 SYNE2 UGDH CD44 LRP1	1.54e-05	173	136	6	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDAH1 CYP2S1 SLC8A1 UGDH CD44 CTNNB1	1.70e-05	176	136	6	1dd54bfaa58541de51e5a8328651d390833bd480
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1E CCND2 GRIP1 BNIP3L CD44 CSTB	1.87e-05	179	136	6	6624a2e731ab2d6c2eec19445e3dc509f581a8a9
ToppCell	facs-Heart-RA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2S1 TMEM45B PROM2 TONSL INAVA CDH1	1.99e-05	181	136	6	c68d272eb41f81bd8ea4d0360733a2396bc87037
ToppCell	facs-Heart-RA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2S1 TMEM45B PROM2 TONSL INAVA CDH1	1.99e-05	181	136	6	5e5eb89f224ee48065a328ade030cbc4dcdcac12
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	DAPK1 PTK2 GRIP1 BMPR1B CDH1 FAM149A	1.99e-05	181	136	6	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 GRIP1 BMPR1B INAVA CDH1 FAM149A	2.05e-05	182	136	6	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 GRIP1 BMPR1B SLC8A1 TMEM45B CDH1	2.12e-05	183	136	6	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	3'_v3-GI_small-bowel-Myeloid_Dendritic\|GI_small-bowel / Manually curated celltypes from each tissue	STARD8 DAPK1 CYP2S1 PTK2 SLC8A1 ROBO1	2.12e-05	183	136	6	6109199cf25b28831193a5ed7925b5bf38c6eb43
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL6A5 ZNF385D NKD1 LRP4 ROBO1 CDK4	2.12e-05	183	136	6	f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell	3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1\|GI_small-bowel / Manually curated celltypes from each tissue	STARD8 DAPK1 CYP2S1 PTK2 SLC8A1 ROBO1	2.18e-05	184	136	6	8e393eea7240584a3cef718bee094e2705ec1891
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DDAH1 DAPK1 PTK2 GRIP1 CDH1 FAM149A	2.25e-05	185	136	6	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 GRIP1 BMPR1B SLC8A1 CDH1	2.32e-05	186	136	6	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	VWA3A ANK2 HTRA3 NKD1 PDLIM3 ROBO1	2.39e-05	187	136	6	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL6A6 BNIP3L PGAP1 UGDH LRP1 ROBO1	2.39e-05	187	136	6	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	FRAS1 COL6A6 NKD1 PDLIM3 PGAP1 ROBO1	2.39e-05	187	136	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 GRIP1 BMPR1B SLC8A1 TMEM45B CDH1	2.39e-05	187	136	6	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX1 CCND2 GRIP1 BMPR1B PROM2 CDH1	2.46e-05	188	136	6	6fb37e3b139955e6ee6be26ab6cd3ce85d765ca6
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 ITSN1 HDAC7 GRIP1 NKD1 CD44	2.46e-05	188	136	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ANK2 DAPK1 SLC8A1 PROM2 CDH1	2.54e-05	189	136	6	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 ANK2 DAPK1 SLC8A1 PROM2 CDH1	2.54e-05	189	136	6	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HECW1 ZNF385D FAH NKD1 LRP4 ROBO1	2.61e-05	190	136	6	d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 GRIP1 BMPR1B TMEM45B PGAP1 CDH1	2.61e-05	190	136	6	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SALL3 BMPR1B SLC8A1 TMEM45B PROM2 CDH1	2.61e-05	190	136	6	d4910c37045a8b8bb53b37625263bc0a47b6e3f8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 GRIP1 BMPR1B TMEM45B PROM2 CDH1	2.69e-05	191	136	6	0a0719a0a49ae0099d61e22585ac74c10c24b4a2
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 ANK2 COL6A6 HTRA3 COL6A5 PDLIM3	2.69e-05	191	136	6	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 ANK2 COL6A6 HTRA3 COL6A5 PDLIM3	2.69e-05	191	136	6	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	COVID-19-kidney-CNT\|kidney / Disease (COVID-19 only), tissue and cell type	FRAS1 SALL3 GRIP1 ZNF385D BMPR1B SLC8A1	2.77e-05	192	136	6	d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 COL6A6 COL6A5 PDLIM3 LRP1 ROBO1	2.77e-05	192	136	6	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 COL6A6 COL6A5 NKD1 LRP1 ROBO1	2.85e-05	193	136	6	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRIP1 BMPR1B SLC8A1 TMEM45B CDH1	2.94e-05	194	136	6	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DAPK1 GRIP1 BMPR1B SLC8A1 TMEM45B CDH1	2.94e-05	194	136	6	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 COL6A6 COL6A5 NKD1 LRP1 ROBO1	2.94e-05	194	136	6	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	FRAS1 ANK2 ACOX3 GRIP1 SLC8A1 PDLIM3	2.94e-05	194	136	6	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANK2 COL6A6 COL6A5 PDLIM3 LRP1 ROBO1	2.94e-05	194	136	6	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ANK2 DAPK1 GRIP1 TMEM45B CDH1	3.11e-05	196	136	6	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DDAH1 CCND2 LEFTY1 PROM2 PGAP1 CDH1	3.11e-05	196	136	6	97324c9e93f833e1f218e81fb53066d44c6892df
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DDAH1 CCND2 LEFTY1 PROM2 PGAP1 CDH1	3.20e-05	197	136	6	c0250509836f1be04f5e54386191d7bb1e1da652
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A6 COL6A5 LEFTY2 LEFTY1 NKD1 PDLIM3	3.20e-05	197	136	6	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 DAPK1 GRIP1 BMPR1B SYNE2 FAM149A	3.29e-05	198	136	6	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 HTRA3 LEFTY2 LEFTY1 NKD1 PDLIM3	3.39e-05	199	136	6	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 HTRA3 LEFTY2 LEFTY1 NKD1 PDLIM3	3.39e-05	199	136	6	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 HTRA3 LEFTY2 LEFTY1 NKD1 PDLIM3	3.39e-05	199	136	6	9a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCell	distal-mesenchymal-Alveolar_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 HTRA3 COL6A5 LEFTY2 LEFTY1 NKD1	3.39e-05	199	136	6	fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A6 HTRA3 COL6A5 LEFTY2 NKD1 PDLIM3	3.39e-05	199	136	6	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	distal-mesenchymal-Alveolar_Fibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL6A6 HTRA3 COL6A5 LEFTY2 LEFTY1 PDLIM3	3.39e-05	199	136	6	655d07cf9a2fd9b945a2ed4f824cba0297de72a8
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 COL6A6 NKD1 PDLIM3 LRP1 ROBO1	3.48e-05	200	136	6	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 COL6A6 NKD1 PDLIM3 LRP1 ROBO1	3.48e-05	200	136	6	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CACNA1E ANK2 TMEM177 PDLIM3 KCTD3	7.29e-05	141	136	5	7ae8ead02e5aeb4106c4a30c08a7a061da3a5d6a
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF385D LEFTY1 NKD1 PDLIM3 SCN5A	1.04e-04	152	136	5	621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADCK5 GDPD4 ZNF385D NKD1 PDLIM3	1.14e-04	155	136	5	cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTK2 BMPR1B UGT2A1 DHX35 FAM149A	1.21e-04	157	136	5	c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A6 DAPK1 CD44 LRP1 CSTB	1.25e-04	158	136	5	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	PBMC-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	ZNF300 HDAC7 LRP8 TMEM177 SLAIN1	1.32e-04	160	136	5	4dac64e58d9366c399f3d830848ccb720d400be7
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A6 DAPK1 CD44 LRP1 CSTB	1.40e-04	162	136	5	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GRIP1 PROM2 UGT2A1 TTLL10 CDH1	1.40e-04	162	136	5	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LRP8 ZNF385D CELSR3 HYAL3 CARD6	1.40e-04	162	136	5	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr\|Thalamus / BrainAtlas - Mouse McCarroll V32	TULP2 NXF3 INAVA CDH1	1.46e-04	87	136	4	0c3a3ed1f279ed29a0113cc73ae590157a4b7334
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	TULP2 NXF3 INAVA CDH1	1.46e-04	87	136	4	5d1dbbd86d82cbce4f2a3365242eb92d9c821a9e
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2\|Thalamus / BrainAtlas - Mouse McCarroll V32	TULP2 NXF3 INAVA CDH1	1.46e-04	87	136	4	a93dbe73b337cc2d93208822728b9badf30b6870
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)\|Thalamus / BrainAtlas - Mouse McCarroll V32	TULP2 NXF3 INAVA CDH1	1.46e-04	87	136	4	45ef27ba84f731e4b2188813cd6931950e5164ac
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 GRIP1 BMPR1B SLC8A1	1.48e-04	164	136	5	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	droplet-Fat-Scat-21m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A6 POLR2A HTRA3 COL6A5 CDH1	1.53e-04	165	136	5	3f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NCKIPSD DAPK1 PAOX DHX35 ARHGEF37	1.53e-04	165	136	5	94a5211072464fc24592bb107a853ce832e816fe
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FRAS1 DAPK1 BMPR1B PROM2 CDH1	1.53e-04	165	136	5	f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD8 NLRP1 DYSF ARID5A ZNF385D	1.57e-04	166	136	5	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	facs-Marrow-KLS-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETMAR ZBTB47 HTRA3 CDH1 ZNF791	1.61e-04	167	136	5	2812353ff66e76f10bd327ceb0e6b009502a5258
ToppCell	facs-Marrow-KLS-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETMAR ZBTB47 HTRA3 CDH1 ZNF791	1.61e-04	167	136	5	d15168f46c1599d9fc68a05a7b822c4b439f2987
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B4GALNT4 DENND1C TONSL CARD6 SLAIN1	1.66e-04	168	136	5	6c758eb120faf06ff72d157b495e399191c79ec9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	INPPL1 NKD1 TMEM45B INAVA CDK4	1.71e-04	169	136	5	29db25e7c5f31d98a08a35d7ec5ade203242bc50
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related-Oligodendrocyte/OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	INPPL1 NKD1 TMEM45B INAVA CDK4	1.71e-04	169	136	5	b1611e61f635f8f9b87250e026ad30999cbee041
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SALL3 GRIP1 SLC8A1 CDH1	1.71e-04	169	136	5	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STARD8 DAPK1 DYSF SLC8A1 SCN5A	1.71e-04	169	136	5	da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 COL6A6 ZNF385D PDLIM3 ROBO1	1.71e-04	169	136	5	559e98216720e4babf0b0941100f1b485c35b11b
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 DAPK1 PTK2 SYNE2 FAM149A	1.75e-04	170	136	5	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1E CCND2 GRIP1 BNIP3L CD44	1.85e-04	172	136	5	965a9f62b73a7e3531c343121a7c507b7e1bfe05
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NCKIPSD CCND2 PTPA CELSR3 SYNE2	1.85e-04	172	136	5	eee45759284baa3ed77da6a5fbcc4f8f6c553106
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 COL6A6 CYP2S1 GRIP1 SYNE2	1.90e-04	173	136	5	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITSN1 SLC8A1 CELSR3 CD44 LRP1	1.90e-04	173	136	5	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FRAS1 COL6A6 CYP2S1 GRIP1 SYNE2	1.90e-04	173	136	5	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAN GRIP1 BMPR1B SLC8A1 CDH1	2.06e-04	176	136	5	b942227abf9902ba13fac6c3e9efb0cacc82af94
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 COL6A6 COL6A5 LEFTY1 NKD1	2.11e-04	177	136	5	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 COL6A6 COL6A5 LEFTY1 NKD1	2.11e-04	177	136	5	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NCKIPSD TINF2 HYAL3 INAVA CPSF3	2.17e-04	178	136	5	89f0537459a321ded956bf70ad56fefc0854f8b0
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	FRAS1 GRIP1 BMPR1B PROM2 SYNE2	2.17e-04	178	136	5	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
Drug	tubulin polymerization inhibitor	RAN HMBS TRRAP DDX5 PAOX LEFTY1 BRD4 TONSL CDK4	1.78e-07	142	135	9	CID010125800
Drug	nafenopin	EPHX1 ACOX3 LEFTY2 FAH LEFTY1 CSTB CDK4	2.14e-07	71	135	7	CID000019592
Drug	Clark 2	NLRP1 CTNNB1 CDH1	4.02e-06	6	135	3	CID000064506
Drug	HMBA	RAN HMBS TRRAP DDX5 LEFTY1 BRD4 CD44 CDK4	4.51e-06	157	135	8	CID000003616
Disease	invasive lobular carcinoma (is_implicated_in)	CCND2 CD44 CDH1	3.41e-07	4	131	3	DOID:3457 (is_implicated_in)
Disease	nephroblastoma (is_marker_for)	CCND2 CD44 CTNNB1 CDK4	1.55e-05	34	131	4	DOID:2154 (is_marker_for)
Disease	thyroid gland papillary carcinoma (is_marker_for)	BRD4 CTNNB1 CDH1	3.00e-05	14	131	3	DOID:3969 (is_marker_for)
Disease	Gastric Adenocarcinoma	TRRAP BMPR1B WEE2 CTNNB1	4.80e-05	45	131	4	C0278701
Disease	Cryptophthalmos syndrome	FRAS1 GRIP1	5.85e-05	3	131	2	C0265233
Disease	glycosyl ceramide (d16:1/24:1, d18:1/22:1) measurement	ATP10D SYNE2	5.85e-05	3	131	2	EFO_0800530
Disease	FRASER SYNDROME 1	FRAS1 GRIP1	5.85e-05	3	131	2	C4551480
Disease	nephrocalcinosis (implicated_via_orthology)	BRD4 POLG2	5.85e-05	3	131	2	DOID:12679 (implicated_via_orthology)
Disease	Mammary Neoplasms, Experimental	EPHX1 RAN PTK2 CD44 CDH1 CDK4	6.94e-05	155	131	6	C0024668
Disease	epilepsy (implicated_via_orthology)	CACNA1E ANK2 SBF1 SCN5A LRP1 DEPDC5	9.16e-05	163	131	6	DOID:1826 (implicated_via_orthology)
Disease	Fraser syndrome (implicated_via_orthology)	FRAS1 GRIP1	1.17e-04	4	131	2	DOID:0090001 (implicated_via_orthology)
Disease	sick sinus syndrome (is_implicated_in)	ANK2 SCN5A	1.94e-04	5	131	2	DOID:13884 (is_implicated_in)
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	EPHX1 CD44 CDH1	2.06e-04	26	131	3	C0009405
Disease	Hereditary Nonpolyposis Colorectal Cancer	EPHX1 CD44 CDH1	2.87e-04	29	131	3	C1333990
Disease	clubfoot (implicated_via_orthology)	FRAS1 GRIP1	2.90e-04	6	131	2	DOID:11836 (implicated_via_orthology)
Disease	Ovarian neoplasm	CTNNB1 CDH1	4.05e-04	7	131	2	cv:C0919267
Disease	long QT syndrome (is_implicated_in)	ANK2 SCN5A	4.05e-04	7	131	2	DOID:2843 (is_implicated_in)
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	ATP10D SYNE2	4.05e-04	7	131	2	EFO_0800551
Disease	invasive lobular carcinoma (is_marker_for)	CTNNB1 CDH1	4.05e-04	7	131	2	DOID:3457 (is_marker_for)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1E SCYL1	4.05e-04	7	131	2	DOID:0050951 (implicated_via_orthology)
Disease	Prostatic Neoplasms	EPHX1 ARHGEF5 ITSN1 CCND2 BMPR1B BRD4 ROBO1 CTNNB1 MGA CDH1	4.40e-04	616	131	10	C0033578
Disease	Malignant neoplasm of prostate	EPHX1 ARHGEF5 ITSN1 CCND2 BMPR1B BRD4 ROBO1 CTNNB1 MGA CDH1	4.40e-04	616	131	10	C0376358
Disease	Liver carcinoma	EPHX1 PTK2 ZIC4 CELSR3 TONSL ROBO1 DEPDC5 CTNNB1 CDK4	4.52e-04	507	131	9	C2239176
Disease	Nerve Degeneration	LRP8 CD44 CTNNB1 CDH1	5.20e-04	83	131	4	C0027746
Disease	lung squamous cell carcinoma (is_marker_for)	PTK2 CTNNB1 CDK4	5.49e-04	36	131	3	DOID:3907 (is_marker_for)
Disease	Malignant neoplasm of brain	DAPK1 CTNNB1 CDK4	6.44e-04	38	131	3	C0153633
Disease	prostate cancer (is_marker_for)	HTRA2 PTK2 CTNNB1 CDH1 EP300	6.75e-04	156	131	5	DOID:10283 (is_marker_for)
Disease	Brain Neoplasms	DAPK1 CTNNB1 CDK4	6.95e-04	39	131	3	C0006118
Disease	Cutaneous Melanoma	TRRAP CTNNB1 CDK4	8.06e-04	41	131	3	C0151779
Disease	Adenocarcinoma of large intestine	TRRAP NEK4 CTNNB1 EP300	8.99e-04	96	131	4	C1319315
Disease	Adenoid Cystic Carcinoma	DAPK1 MGA CDH1 EP300	1.05e-03	100	131	4	C0010606
Disease	Pancreatic Neoplasm	CD44 CTNNB1 CDH1 EP300	1.05e-03	100	131	4	C0030297
Disease	Macrocephaly	CACNA1E CCND2	1.05e-03	11	131	2	C0221355
Disease	Leukemia, Myelocytic, Acute	EPHX1 DAPK1 CCND2 CD44 EP300	1.07e-03	173	131	5	C0023467
Disease	Malignant neoplasm of pancreas	CD44 CTNNB1 CDH1 EP300	1.13e-03	102	131	4	C0346647
Disease	Colorectal Carcinoma	STARD8 SALL3 ANK2 CCND2 ZNF385D LRP1 CTNNB1 TTLL10 CDH1 EP300	1.19e-03	702	131	10	C0009402
Disease	Salivary Gland Neoplasms	DAPK1 CTNNB1 CDH1	1.20e-03	47	131	3	C0036095
Disease	cancer (implicated_via_orthology)	HMBS DDX5 LLGL1 DEPDC5 CTNNB1 CDK4	1.29e-03	268	131	6	DOID:162 (implicated_via_orthology)
Disease	urinary bladder cancer (is_marker_for)	HMBS CD44 CTNNB1 CDH1	1.35e-03	107	131	4	DOID:11054 (is_marker_for)
Disease	Glioblastoma Multiforme	PTK2 BRD4 CSTB STKLD1	1.54e-03	111	131	4	C1621958
Disease	urinary bladder cancer (biomarker_via_orthology)	CDH1 CDK4	1.72e-03	14	131	2	DOID:11054 (biomarker_via_orthology)
Disease	familial atrial fibrillation (is_implicated_in)	NUP155 SCN5A	1.72e-03	14	131	2	DOID:0050650 (is_implicated_in)
Disease	Metastatic melanoma	SCYL1 PTK2 BMPR1B	1.80e-03	54	131	3	C0278883
Disease	Polydactyly	FRAS1 CCND2 GRIP1 LRP4	1.87e-03	117	131	4	C0152427
Disease	prostate cancer (is_implicated_in)	CCND2 CD44 CDH1 CDK4	1.87e-03	117	131	4	DOID:10283 (is_implicated_in)
Disease	hepatoblastoma (is_marker_for)	CTNNB1 CDH1	1.98e-03	15	131	2	DOID:687 (is_marker_for)
Disease	Romano-Ward Syndrome	ANK2 SCN5A	2.25e-03	16	131	2	C0035828
Disease	T-Cell Lymphoma	MGA EP300	2.25e-03	16	131	2	C0079772
Disease	Acute Myeloid Leukemia, M1	EPHX1 DAPK1 CCND2 CD44	2.38e-03	125	131	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	EPHX1 DAPK1 CCND2 CD44	2.38e-03	125	131	4	C1879321
Disease	CCL2 measurement	NCKIPSD ZBTB47 HDAC7 FAM149A	2.45e-03	126	131	4	EFO_0004749
Disease	Multiple congenital anomalies	LEFTY2 CTNNB1	2.55e-03	17	131	2	C0000772
Disease	schizophrenia, irritable bowel syndrome	LRP8 EP300	2.55e-03	17	131	2	EFO_0000555, MONDO_0005090
Disease	caudal anterior cingulate cortex volume measurement	HECW1 ZNF385D	2.55e-03	17	131	2	EFO_0010289
Disease	obsolete_red blood cell distribution width	AVL9 ITSN1 ST7L PTK2 PTPA BNIP3L CSNK1G2 BRD4 UGT2A3 SYNE2 SLC15A5 STKLD1 CDH1 EP300	2.69e-03	1347	131	14	EFO_0005192
Disease	transitional cell carcinoma (is_marker_for)	BRD4 CTNNB1 CDK4	2.80e-03	63	131	3	DOID:2671 (is_marker_for)
Disease	carcinoma (implicated_via_orthology)	SALL3 LLGL1 CTNNB1	2.92e-03	64	131	3	DOID:305 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	STARD8 ANK2 DYSF ADAR HDAC7 LLGL1 SYNE2 ROBO1 CTNNB1 CDH1 CPSF3 EP300	3.05e-03	1074	131	12	C0006142
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	EPHX1 CDH1	3.18e-03	19	131	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	EPHX1 CDH1	3.18e-03	19	131	2	C2936783
Disease	Microcephaly	TRRAP BRD4 TBCD	3.33e-03	67	131	3	C0025958
Disease	Animal Mammary Neoplasms	EPHX1 RAN CDH1 CDK4	3.76e-03	142	131	4	C0024667
Disease	stomach cancer (is_marker_for)	HTRA2 ADAR CCND2 CTNNB1	3.76e-03	142	131	4	DOID:10534 (is_marker_for)
Disease	Mammary Carcinoma, Animal	EPHX1 RAN CDH1 CDK4	3.76e-03	142	131	4	C1257925
Disease	hepatitis B (is_marker_for)	CCND2 CTNNB1	3.89e-03	21	131	2	DOID:2043 (is_marker_for)
Disease	ulcerative colitis	ZNF300 HDAC7 CCNY CELSR3 INAVA DNPEP	3.91e-03	335	131	6	EFO_0000729
Disease	Endometrial Carcinoma	CTNNB1 CDH1 EP300	4.08e-03	72	131	3	C0476089
Disease	hemorrhoid	HDAC7 ACOX3 BMPR1B UGDH	4.25e-03	147	131	4	EFO_0009552
Disease	seminoma (is_marker_for)	HMBS CCND2	4.26e-03	22	131	2	DOID:4440 (is_marker_for)
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	NUP155 SCN5A	4.26e-03	22	131	2	C1843687
Disease	transitional cell carcinoma (is_implicated_in)	CCND2 CD44	4.26e-03	22	131	2	DOID:2671 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KAVINHTFGVPLPHR	ZNF385D	61	Q9H6B1
HTFGVPLPHRRKQII	ZNF385D	66	Q9H6B1
PVPKGVLRIHFIEAQ	ESYT2	381	A0FGR8
NHLVHKLVQAIFPTP	EP300	581	Q09472
HLTPFPCGIFHKVQV	DAPK1	1136	P53355
ERHTPIERVPHLGFK	ARID5A	71	Q03989
PHGAQVPRLKAALTH	C9orf50	241	Q5SZB4
LVLPHPELEVGKHVV	CACNA1E	1006	Q15878
IRALKPPHVILVHGE	CPSF3	406	Q9UKF6
ENHRPLFHKGPVIKV	DNPEP	371	Q9ULA0
HGLHPFIVQIRDPKT	ACOX3	221	O15254
VFDPIGHFTQPILHL	BRD4	816	O60885
LPHHHVPEPAFRKLV	ARHGEF37	446	A1IGU5
GQARQPEKPSHLHLE	ARHGEF5	986	Q12774
FPHVQTDVLVRVKGP	AP4B1	266	Q9Y6B7
HLRVFQSLPHENKPL	CSTB	66	P04080
FIHSDPHPGNVLVRK	ADCK5	356	Q3MIX3
RKSLFINHHPPGQIA	CCNY	81	Q8ND76
VHIPAAVGHPVKLRV	AADACL3	31	Q5VUY0
KPGAPLQAFHRRAVH	DENND1C	366	Q8IV53
PPLKNRDFVDGPIHH	BMPR1B	111	O00238
LSHHPKFIPEFIRKQ	DPM1	121	O60762
LSGRHRIVVPHIQPF	ATP10D	46	Q9P241
EAIHIPHRKPQGVDP	NKD1	301	Q969G9
EVHPLVFHTNRGPIK	RAN	46	P62826
DVHVFSVPGLRPQVH	LLGL1	886	Q15334
PVIVEIPHFAALRGK	ANK2	1076	Q01484
PHDFIEHILRKLPQQ	CCND2	156	P30279
PHIKLGDIVEIAHPN	DEPDC5	31	O75140
EQPLHAVPLFKLHNR	DEPDC5	371	O75140
NPAGIPHFVHRELKS	NXF3	186	Q9H4D5
RLHYGLPVVVKLLHP	CTNNB1	486	P35222
RPPQHGVLLKHTAEF	FRAS1	1636	Q86XX4
FQEPVPKAALHRHGR	LEFTY1	121	O75610
GKAEPHVLGRVFIHP	MGA	146	Q8IWI9
LKVAGNRFPHVLVPH	FAM149A	491	A5PLN7
FHQHEVRFDKPPLRL	ERVFC1-1	51	P60608
FPALPHHGQERRSKI	HECW1	241	Q76N89
LEQPHGLVVHPLRGK	LRP1	1701	Q07954
PGTKRQHAIHIIDFG	CSNK1G2	176	P78368
PAIVHINHQPFLERG	DDX5	151	P17844
LHLRPFPVDHKGVLS	C9orf131	286	Q5VYM1
LGSILHDPNIFKHPE	CYP2S1	396	Q96SQ9
IGLSVIHRFGKQAPH	OR51G2	261	Q8NGK0
IEKQGRIHPDLQPHN	NEK4	511	P51957
KPARVELHHIVLENP	NLRP1	1196	Q9C000
FREQVFPVDALHHKP	POLG2	121	Q9UHN1
PPKHPLRHTFVRQVV	GDPD4	336	Q6W3E5
KPKAGIFQPHVRHLL	NUP155	151	O75694
RIHPEPVIRFHKAAF	SBF1	391	O95248
ARIPHGLKVQPHFIE	PCDHAC2	766	Q9Y5I4
AELVSFKHPHVANPR	PCID2	26	Q5JVF3
HIQFPKPHPGHEVRL	EFCAB5	916	A4FU69
EPSFPDVQHGVLIHK	HTRA2	381	O43464
APAVVHIELFLRHPL	HTRA3	151	P83110
EGLDIHFIHVKPPQL	EPHX1	121	P07099
GLRHEVLKHENTVPP	CARD6	91	Q9BX69
IPRPKLLQHYLHAGV	C3orf84	176	H3BNL1
FEDGLRHPFIVNHPK	ADAR	1091	P55265
RHPFIVNHPKVGRVS	ADAR	1096	P55265
FIEGHVVIPRIHPNS	CD44	81	P16070
PHSGHFVALKSVRVP	CDK4	26	P11802
FVVPPNQKSHAIRVH	DHX35	521	Q9H5Z1
VPRGPVLHIVVVGFH	AVL9	11	Q8NBF6
PLDHHLVQLGRTHKP	COL6A5	2461	A8TX70
GRLFHQHQEPAKPAV	ITSN1	706	Q15811
ALVGHRHPLPVLAYV	HYAL3	271	O43820
IPPKEFHFRHPKRSV	BNIP3L	151	O60238
HVFQHAVPQEGKPIT	BLMH	51	Q13867
FQEPVPKAALHRHGR	LEFTY2	121	O00292
INHNTPGLPKIYIHR	DDX49	321	Q9Y6V7
RLGEPIPISKAHEHI	FAH	211	P16930
ELKNGFAVVRPPGHH	HDAC7	656	Q8WUI4
RENPHDAVVFHPKFV	HMBS	116	P08397
LPSDFLIRHHGPKPV	CELSR3	171	Q9NYQ7
EILPHHQTRLALKGP	GRIP1	331	Q9Y3R0
IHRKHFPAVEQPLSG	SLC15A5	406	A6NIM6
FGVHRAKPPLRVQHS	SALL3	726	Q9BXA9
LIQREKPAIHHIPGF	DYSF	1276	O75923
KPAIHHIPGFEVQET	DYSF	1281	O75923
VPAGSRELVAHHPKL	INAVA	496	Q3KP66
PVDPRKVLIVAGHHN	KCTD3	181	Q9Y597
NIPNKGHVLLHRTPE	DDAH1	226	O94760
KRPLRFHNPQIHFLV	CDH1	86	P12830
PLDHHLVQLGRIHKP	COL6A6	2136	A6NMZ7
NPHDIVIFHELKQPR	LRP8	671	Q14114
DRFPAHHVIVTVPLG	PAOX	276	Q6QHF9
KHLESFPKQGPIRHF	MRPS31	336	Q92665
QRHNLQPFHPKLGDV	RAPGEF6	1571	Q8TEU7
PGNFVLKELHPFDLH	SYNE2	1281	Q8WXH0
PHVVHGFLDTNPAIR	SCYL1	391	Q96KG9
RHEGREPLLVVKPTH	FAM90A12P	216	A8MX19
RQFDHPHIVKLIGVI	PTK2	476	Q05397
RIITHPDFEKLHPFG	PRSS47P	156	A8MTI9
PFHPIRRAAVKILVH	SCN5A	116	Q14524
HSVGHFPVSIRQPLK	SLAIN1	461	Q8ND83
KVAITVPAPQLGHHR	INPPL1	1016	O15357
KGPILLHDNARPHVA	SETMAR	581	Q53H47
IRHPSKHFEENPAII	PGAP1	326	Q75T13
EHKHNIRPKPFVIPG	PDLIM3	116	Q53GG5
ELLGHPVEKPVVLHR	PHAF1	356	Q9BSU1
VRIFKHEPQPPHSVL	NCKIPSD	601	Q9NZQ3
GQHVFGVPPLIHVQR	STARD8	566	Q92502
LHIHFPPNILDGIRK	B4GALNT4	916	Q76KP1
ILAEQFVPDGPHLHL	TMEM45B	61	Q96B21
IHKEFLELARDPQPH	UBE2DNL	6	Q8IWF7
GAHLHIYDPKVPREQ	UGDH	361	O60701
QLTEHQRIHPGIKPY	ZNF565	501	Q8N9K5
KHQEHLVLQFGRVGP	TULP2	481	O00295
PAFRVHVRVHTGEKP	ZNF791	341	Q3KP31
PLIQHQRIHTGEKPY	ZNF135	536	P52742
VPSVDHVLHQLKGVP	PROM2	326	Q8N271
LLGQALVHHPEAKAP	STKLD1	396	Q8NE28
IQHFKFGSLLPIHPV	PTPA	341	Q15257
KALNHHFPESGPIVR	TINF2	81	Q9BSI4
RVQVQDHLFLIPVPH	TONSL	936	Q96HA7
QKIFHINPRLPSDLH	POLR2A	991	P24928
LIPQGIVKLDHPRIH	TUSC2	86	O75896
IVKLDHPRIHVDFPV	TUSC2	91	O75896
KPHLLYRPLEQQHGV	XRN1	1081	Q8IZH2
HQGALVERIIPHPLY	TMPRSS5	286	Q9H3S3
EAIHRAVEFNPHVPK	ST7L	401	Q8TDW4
QTFGGKHLVHILPRP	USF3	626	Q68DE3
GRPHHDLPVILVGNK	REM2	216	Q8IYK8
PHFVVKPRDQVVALG	ROBO1	351	Q9Y6N7
LVPQRSVFPAHKGVL	ZBTB47	21	Q9UFB7
LLPIQHVPGADFLHV	nan	131	Q0VFX4
LVNHIRVHTGEKPFP	ZIC4	191	Q8N9L1
LGHRVPKPELVHLLE	ZNF550	51	Q7Z398
IHHDQPVKPLDRAVF	UGT2A3	446	Q6UWM9
SHLPELHIFQPEGKI	ZNF28	146	P17035
HLVPHQRIHTGEKPL	ZNF594	281	Q96JF6
IPHVPHRGELEKLFP	TBCD	936	Q9BTW9
HHIRKGNFPDVPQEL	WEE2	441	P0C1S8
PVETHHIDIKGPALI	VWA8	1066	A3KMH1
GNIVPRHLFRIKHLP	TMEM177	276	Q53S58
IHHDQPVKPLDRAVF	UGT2A1	446	P0DTE4
PIHHKTPFRGPQARV	TTLL10	346	Q6ZVT0
LHLPEPHIFQSEGKI	ZNF468	146	Q5VIY5
KQFRPPITQEIHHFL	TRRAP	141	Q9Y4A5
SPLIIHQRIHTGEKP	ZNF300	366	Q96RE9
HDGTVKNIHVDPPFL	VWA3A	461	A6NCI4
QEILEKNPRFHHLTP	YEATS2	1206	Q9ULM3
YIVQHRPPQEAKGVH	ZDHHC1	281	Q8WTX9
HRKAVISQGLPHPFA	LRP4	631	O75096
FGQPVFRKVHAREHP	SLC8A1	656	P32418