Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein intermediate chain binding	SPTBN5 DNAH12 DNAH17 DNAH6 DNAH7	6.12e-07	37	89	5	GO:0045505
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH17 DNAH6 DNAH7	1.08e-06	18	89	4	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH12 DNAH17 DNAH6 DNAH7	6.96e-06	28	89	4	GO:0051959
GeneOntologyMolecularFunction	microtubule motor activity	DNAH12 DNAH17 DNAH6 DNAH7	2.70e-04	70	89	4	GO:0003777
GeneOntologyMolecularFunction	translation termination factor activity	GSPT2 GSPT1	4.07e-04	7	89	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	GSPT2 GSPT1	4.07e-04	7	89	2	GO:0003747
GeneOntologyMolecularFunction	aspartic endopeptidase activity, intramembrane cleaving	SPPL2A SPPL2C	5.41e-04	8	89	2	GO:0042500
GeneOntologyBiologicalProcess	cell junction assembly	DOCK1 ACE2 DRD2 NRXN3 SETD5 EPHA2 LRP4 SRGAP2 IL1RAP ECT2 RAB29 CDH1	5.94e-06	569	89	12	GO:0034329
GeneOntologyBiologicalProcess	synapse assembly	DOCK1 DRD2 NRXN3 SETD5 LRP4 SRGAP2 IL1RAP RAB29 CDH1	7.33e-06	308	89	9	GO:0007416
GeneOntologyBiologicalProcess	glial cell-derived neurotrophic factor production	DRD2 SORL1	1.84e-05	2	89	2	GO:0044467
GeneOntologyBiologicalProcess	regulation of glial cell-derived neurotrophic factor production	DRD2 SORL1	1.84e-05	2	89	2	GO:1900166
GeneOntologyBiologicalProcess	positive regulation of glial cell-derived neurotrophic factor production	DRD2 SORL1	1.84e-05	2	89	2	GO:1900168
GeneOntologyBiologicalProcess	cell junction organization	DOCK1 ACE2 DRD2 NRXN3 GPR158 SETD5 EPHA2 LRP4 SPG11 SRGAP2 IL1RAP ECT2 RAB29 CDH1	6.99e-05	974	89	14	GO:0034330
GeneOntologyBiologicalProcess	positive regulation of intracellular protein transport	ECT2 RAB29 CDH1 HYAL2 SORL1	1.47e-04	116	89	5	GO:0090316
GeneOntologyBiologicalProcess	localization within membrane	NRXN3 GPR158 EPHA2 TM9SF3 EXOC6B LRP4 PRPH2 SPG11 RAB29 CDH1 VPS53 SORL1	1.60e-04	798	89	12	GO:0051668
GeneOntologyBiologicalProcess	synapse organization	DOCK1 DRD2 NRXN3 GPR158 SETD5 LRP4 SPG11 SRGAP2 IL1RAP RAB29 CDH1	1.74e-04	685	89	11	GO:0050808
GeneOntologyCellularComponent	axonemal dynein complex	DNAH12 DNAH17 DNAH6 DNAH7	3.79e-06	25	90	4	GO:0005858
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH6 DNAH7	9.06e-06	10	90	3	GO:0036156
GeneOntologyCellularComponent	translation release factor complex	GSPT2 GSPT1	5.48e-05	3	90	2	GO:0018444
GeneOntologyCellularComponent	9+2 motile cilium	DRD2 DNAH12 KCNU1 DNAH17 PGAM4 DNAH6 DNAH7	7.60e-05	238	90	7	GO:0097729
GeneOntologyCellularComponent	dynein complex	DNAH12 DNAH17 DNAH6 DNAH7	8.62e-05	54	90	4	GO:0030286
GeneOntologyCellularComponent	axoneme	SPTBN5 DNAH12 WDR11 DNAH17 DNAH6 DNAH7	2.74e-04	207	90	6	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	SPTBN5 DNAH12 WDR11 DNAH17 DNAH6 DNAH7	2.81e-04	208	90	6	GO:0097014
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	ACE2 CD1B DRD2 SPPL2A PTPRB ATR OTOF ANO6 OSBPL6 OCA2 SNX21 DMD VPS53 SPPL2C SORL1	4.37e-04	1307	90	15	GO:0030659
GeneOntologyCellularComponent	cilium	SPTBN5 ACE2 NPR2 DRD2 DNAH12 KCNU1 WDR11 DNAH17 PGAM4 PRPH2 DNAH6 DNAH7	4.60e-04	898	90	12	GO:0005929
GeneOntologyCellularComponent	vesicle membrane	ACE2 CD1B DRD2 SPPL2A PTPRB ATR OTOF ANO6 OSBPL6 OCA2 SNX21 DMD VPS53 SPPL2C SORL1	5.05e-04	1325	90	15	GO:0012506
GeneOntologyCellularComponent	vacuole	CD1B SPPL2A WDR11 OSBPL7 MIOS PSMD1 SPG11 OCA2 TRAF3IP3 RAB29 SPPL2C HYAL2	5.34e-04	913	90	12	GO:0005773
GeneOntologyCellularComponent	lateral plasma membrane	DRD2 VANGL1 DMD CDH1	6.19e-04	90	90	4	GO:0016328
GeneOntologyCellularComponent	microtubule associated complex	SPTBN5 DNAH12 DNAH17 DNAH6 DNAH7	6.61e-04	161	90	5	GO:0005875
GeneOntologyCellularComponent	GABA-ergic synapse	DRD2 NRXN3 ATR NXPH1 DMD	7.18e-04	164	90	5	GO:0098982
GeneOntologyCellularComponent	lysosomal membrane	CD1B SPPL2A WDR11 MIOS SPG11 OCA2 TRAF3IP3 SPPL2C	8.53e-04	462	90	8	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	CD1B SPPL2A WDR11 MIOS SPG11 OCA2 TRAF3IP3 SPPL2C	8.53e-04	462	90	8	GO:0098852
GeneOntologyCellularComponent	motile cilium	DRD2 DNAH12 KCNU1 DNAH17 PGAM4 DNAH6 DNAH7	8.58e-04	355	90	7	GO:0031514
GeneOntologyCellularComponent	synaptic membrane	DRD2 NRXN3 OTOF GPR158 ANO6 SYNE1 LRP4 SRGAP2 DMD	9.11e-04	583	90	9	GO:0097060
GeneOntologyCellularComponent	membrane raft	AKAP6 ACE2 LRP4 PLD2 DMD CDH1 HYAL2	9.61e-04	362	90	7	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	AKAP6 ACE2 LRP4 PLD2 DMD CDH1 HYAL2	9.92e-04	364	90	7	GO:0098857
GeneOntologyCellularComponent	lumenal side of membrane	SPPL2A DMD SPPL2C	1.16e-03	48	90	3	GO:0098576
GeneOntologyCellularComponent	vacuolar membrane	CD1B SPPL2A WDR11 MIOS SPG11 OCA2 TRAF3IP3 SPPL2C	1.54e-03	507	90	8	GO:0005774
GeneOntologyCellularComponent	trans-Golgi network	WDR11 ST3GAL1 RAB29 CDH1 VPS53 SORL1	2.08e-03	306	90	6	GO:0005802
GeneOntologyCellularComponent	dendritic spine head	SYNE1 SRGAP2	2.12e-03	16	90	2	GO:0044327
GeneOntologyCellularComponent	perinuclear region of cytoplasm	AKAP6 RANBP2 SYNE1 OSBPL7 OSBPL6 DMD RAB29 CDH1 VPS53 HYAL2 SORL1	2.21e-03	934	90	11	GO:0048471
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	SPTBN5 DNAH12 WDR11 DNAH17 DNAH6 DNAH7	2.49e-03	317	90	6	GO:0032838
GeneOntologyCellularComponent	lysosome	CD1B SPPL2A WDR11 MIOS PSMD1 SPG11 OCA2 TRAF3IP3 SPPL2C HYAL2	2.54e-03	811	90	10	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	CD1B SPPL2A WDR11 MIOS PSMD1 SPG11 OCA2 TRAF3IP3 SPPL2C HYAL2	2.54e-03	811	90	10	GO:0000323
GeneOntologyCellularComponent	Golgi apparatus subcompartment	WDR11 GAL3ST4 ST3GAL1 RAB29 CDH1 VPS53 SORL1	3.02e-03	443	90	7	GO:0098791
GeneOntologyCellularComponent	lamellipodium	EPHA2 SRGAP2 PLD2 DMD CDH1	3.18e-03	230	90	5	GO:0030027
GeneOntologyCellularComponent	plasma membrane raft	AKAP6 LRP4 PLD2 CDH1	3.76e-03	147	90	4	GO:0044853
GeneOntologyCellularComponent	cytoplasmic side of endoplasmic reticulum membrane	SPPL2A SPPL2C	4.00e-03	22	90	2	GO:0098554
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	AKAP6 RANBP2 SPPL2A OTOF SYNE1 OSBPL7 OSBPL6 ANO5 OCA2 TRAF3IP3 PLD2 SPPL2C SORL1	4.37e-03	1327	90	13	GO:0042175
GeneOntologyCellularComponent	cytoplasmic region	SPTBN5 DNAH12 WDR11 DNAH17 DNAH6 DNAH7	4.63e-03	360	90	6	GO:0099568
Domain	EGF	MEP1A FCGBP NRXN3 BRINP2 LRP4 NID1 HYAL2 SORL1	1.27e-05	235	86	8	SM00181
Domain	Spectrin/alpha-actinin	AKAP6 SPTBN5 SYNE1 DMD	1.37e-05	32	86	4	IPR018159
Domain	SPEC	AKAP6 SPTBN5 SYNE1 DMD	1.37e-05	32	86	4	SM00150
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH6 DNAH7	3.31e-05	14	86	3	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH6 DNAH7	3.31e-05	14	86	3	IPR013602
Domain	DHC_N2	DNAH12 DNAH6 DNAH7	3.31e-05	14	86	3	PF08393
Domain	AAA_8	DNAH12 DNAH6 DNAH7	3.31e-05	14	86	3	PF12780
Domain	Ldl_recept_b	LRP4 NID1 SORL1	3.31e-05	14	86	3	PF00058
Domain	LDLRB	LRP4 NID1 SORL1	3.31e-05	14	86	3	PS51120
Domain	DHC_fam	DNAH12 DNAH6 DNAH7	4.12e-05	15	86	3	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH6 DNAH7	4.12e-05	15	86	3	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH6 DNAH7	4.12e-05	15	86	3	PF03028
Domain	LY	LRP4 NID1 SORL1	4.12e-05	15	86	3	SM00135
Domain	LDLR_classB_rpt	LRP4 NID1 SORL1	4.12e-05	15	86	3	IPR000033
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD2	6.27e-05	3	86	2	IPR015727
Domain	PH_dom-like	PRKD3 SPTBN5 PRKD2 RANBP2 MTMR11 OSBPL7 OSBPL6 PLD2 ECT2	1.50e-04	426	86	9	IPR011993
Domain	EGF-like_dom	MEP1A FCGBP NRXN3 LRP4 NID1 HYAL2 SORL1	1.51e-04	249	86	7	IPR000742
Domain	Actinin_actin-bd_CS	SPTBN5 SYNE1 DMD	1.56e-04	23	86	3	IPR001589
Domain	Spectrin	SPTBN5 SYNE1 DMD	1.56e-04	23	86	3	PF00435
Domain	ACTININ_2	SPTBN5 SYNE1 DMD	1.56e-04	23	86	3	PS00020
Domain	ACTININ_1	SPTBN5 SYNE1 DMD	1.56e-04	23	86	3	PS00019
Domain	EGF-like_CS	MEP1A NRXN3 EPHA2 LRP4 NID1 HYAL2 SORL1	2.02e-04	261	86	7	IPR013032
Domain	Peptidase_A22B_SPP	SPPL2A SPPL2C	2.08e-04	5	86	2	IPR007369
Domain	Peptidase_A22B	SPPL2A SPPL2C	2.08e-04	5	86	2	PF04258
Domain	EGF_2	MEP1A NRXN3 EPHA2 LRP4 NID1 HYAL2 SORL1	2.21e-04	265	86	7	PS01186
Domain	PH	PRKD3 SPTBN5 PRKD2 OSBPL7 OSBPL6 PLD2 ECT2	2.96e-04	278	86	7	SM00233
Domain	PH_DOMAIN	PRKD3 SPTBN5 PRKD2 OSBPL7 OSBPL6 PLD2 ECT2	3.02e-04	279	86	7	PS50003
Domain	PH_domain	PRKD3 SPTBN5 PRKD2 OSBPL7 OSBPL6 PLD2 ECT2	3.09e-04	280	86	7	IPR001849
Domain	Spectrin_repeat	SPTBN5 SYNE1 DMD	3.16e-04	29	86	3	IPR002017
Domain	Anoct_dimer	ANO6 ANO5	4.34e-04	7	86	2	PF16178
Domain	Anoct_dimer	ANO6 ANO5	4.34e-04	7	86	2	IPR032394
Domain	PSN	SPPL2A SPPL2C	4.34e-04	7	86	2	SM00730
Domain	Preselin/SPP	SPPL2A SPPL2C	4.34e-04	7	86	2	IPR006639
Domain	-	PRKD3 SPTBN5 PRKD2 RANBP2 OSBPL7 OSBPL6 PLD2 ECT2	4.39e-04	391	86	8	2.30.29.30
Domain	Transl_elong_EFTu/EF1A_C	GSPT2 GSPT1	5.76e-04	8	86	2	IPR004160
Domain	GTP_EFTU_D3	GSPT2 GSPT1	5.76e-04	8	86	2	PF03143
Domain	PH	PRKD3 SPTBN5 PRKD2 OSBPL7 OSBPL6 PLD2	6.61e-04	229	86	6	PF00169
Domain	G_TR_CS	GSPT2 GSPT1	7.39e-04	9	86	2	IPR031157
Domain	EGF_3	MEP1A NRXN3 LRP4 NID1 HYAL2 SORL1	7.56e-04	235	86	6	PS50026
Domain	-	LRP4 NID1 SORL1	7.64e-04	39	86	3	2.120.10.30
Domain	Transl_elong_EF1A/Init_IF2_C	GSPT2 GSPT1	9.21e-04	10	86	2	IPR009001
Domain	Anoctamin	ANO6 ANO5	9.21e-04	10	86	2	PF04547
Domain	Anoctamin	ANO6 ANO5	9.21e-04	10	86	2	IPR007632
Domain	6-blade_b-propeller_TolB-like	LRP4 NID1 SORL1	1.24e-03	46	86	3	IPR011042
Domain	Oxysterol-bd	OSBPL7 OSBPL6	1.34e-03	12	86	2	IPR000648
Domain	Oxysterol-bd_CS	OSBPL7 OSBPL6	1.34e-03	12	86	2	IPR018494
Domain	Oxysterol_BP	OSBPL7 OSBPL6	1.34e-03	12	86	2	PF01237
Domain	OSBP	OSBPL7 OSBPL6	1.34e-03	12	86	2	PS01013
Domain	G_TR_1	GSPT2 GSPT1	1.58e-03	13	86	2	PS00301
Domain	Dynein_HC_stalk	DNAH6 DNAH7	1.84e-03	14	86	2	IPR024743
Domain	MT	DNAH6 DNAH7	1.84e-03	14	86	2	PF12777
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH6	1.84e-03	14	86	2	IPR011704
Domain	AAA_5	DNAH12 DNAH6	1.84e-03	14	86	2	PF07728
Domain	EGF	MEP1A NRXN3 LRP4 NID1	2.74e-03	126	86	4	PF00008
Domain	EFTu-like_2	GSPT2 GSPT1	3.06e-03	18	86	2	IPR004161
Domain	GTP_EFTU_D2	GSPT2 GSPT1	3.06e-03	18	86	2	PF03144
Domain	G_TR_2	GSPT2 GSPT1	3.06e-03	18	86	2	PS51722
Domain	CH	SPTBN5 SYNE1 DMD	3.35e-03	65	86	3	SM00033
Domain	TF_GTP-bd_dom	GSPT2 GSPT1	3.41e-03	19	86	2	IPR000795
Domain	PA	SPPL2A SPPL2C	3.41e-03	19	86	2	PF02225
Domain	PA_domain	SPPL2A SPPL2C	3.41e-03	19	86	2	IPR003137
Domain	CH	SPTBN5 SYNE1 DMD	4.13e-03	70	86	3	PF00307
Domain	DAG/PE-bd	PRKD3 PRKD2	4.16e-03	21	86	2	IPR020454
Domain	-	SPTBN5 SYNE1 DMD	4.30e-03	71	86	3	1.10.418.10
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH6 DNAH7	1.25e-05	27	76	4	M47755
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ACE2 ANO6 ANO5	4.14e-05	13	76	3	M46426
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH6 DNAH7	8.21e-05	43	76	4	M47669
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH6 DNAH7	9.83e-05	45	76	4	M47670
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH17 DNAH6 DNAH7	4.11e-08	14	90	4	9373155
Pubmed	Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.	PRKD3 PRKD2	6.62e-06	2	90	2	30841931
Pubmed	Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.	GSPT2 GSPT1	6.62e-06	2	90	2	15987998
Pubmed	Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.	ACE2 ANO6	6.62e-06	2	90	2	35670331
Pubmed	Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.	PRKD3 PRKD2	6.62e-06	2	90	2	37044359
Pubmed	Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis.	EPHA2 CDH1	6.62e-06	2	90	2	19048396
Pubmed	The anaphase promoting complex induces substrate degradation during neuronal differentiation.	SKP2 CDH1	6.62e-06	2	90	2	19047054
Pubmed	Curcumol Reduces Aerobic Glycolysis and Overcomes Chemoresistance by Inducing Cdh1-Mediated Skp2 Ubiquitination.	SKP2 CDH1	6.62e-06	2	90	2	36866798
Pubmed	Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis.	EPHA2 CDH1	6.62e-06	2	90	2	14767510
Pubmed	Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.	PRKD3 PRKD2	6.62e-06	2	90	2	24840177
Pubmed	ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis.	ACE2 DMD	6.62e-06	2	90	2	24695436
Pubmed	Increasing LRP4 diminishes neuromuscular deficits in a mouse model of Duchenne muscular dystrophy.	LRP4 DMD	6.62e-06	2	90	2	33987657
Pubmed	Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.	PRKD3 PRKD2	6.62e-06	2	90	2	25802335
Pubmed	Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.	SPPL2A SPPL2C	6.62e-06	2	90	2	30733281
Pubmed	Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.	PRKD3 PRKD2	6.62e-06	2	90	2	23393329
Pubmed	Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.	GSPT2 GSPT1	6.62e-06	2	90	2	24981173
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DOCK1 PCYOX1L EXOC6B GBE1 SRGAP2 VPS53	8.44e-06	183	90	6	31932471
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RANBP2 NRXN3 GSPT2 SETD5 SYNE1 TM9SF3 PGAM4 DNAJC21 PSMD1 SPG11 DMD CDH1 DNAH6 GSPT1	1.97e-05	1442	90	14	35575683
Pubmed	The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population.	PTPRB TRAF3IP3	1.98e-05	3	90	2	36397361
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD2	1.98e-05	3	90	2	26253275
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD2	1.98e-05	3	90	2	27662904
Pubmed	Polypeptide chain release factor eRF3 is a novel molecular partner of survivin.	GSPT2 GSPT1	1.98e-05	3	90	2	23377885
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD2	1.98e-05	3	90	2	38419169
Pubmed	Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.	GSPT2 GSPT1	1.98e-05	3	90	2	9712840
Pubmed	Immunocytochemical colocalization of clusterin in apoptotic photoreceptor cells in retinal degeneration slow rds mutant mouse retinas.	PRPH2 OCA2	1.98e-05	3	90	2	8769098
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD2	1.98e-05	3	90	2	16377259
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD2	1.98e-05	3	90	2	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD2	1.98e-05	3	90	2	26426580
Pubmed	Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7.	OSBPL7 OSBPL6	1.98e-05	3	90	2	14593528
Pubmed	APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.	ECT2 CDH1	1.98e-05	3	90	2	21886810
Pubmed	The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.	GSPT2 GSPT1	1.98e-05	3	90	2	24569073
Pubmed	Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells.	ACE2 SKP2	3.96e-05	4	90	2	33511555
Pubmed	Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.	DOCK1 PLD2	3.96e-05	4	90	2	23362269
Pubmed	Structural insights into eRF3 and stop codon recognition by eRF1.	GSPT2 GSPT1	3.96e-05	4	90	2	19417105
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD2	3.96e-05	4	90	2	14743217
Pubmed	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.	PRKD3 PRKD2	3.96e-05	4	90	2	27670070
Pubmed	A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.	DOCK1 SRGAP2	3.96e-05	4	90	2	23031429
Pubmed	Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.	SPPL2A SPPL2C	6.59e-05	5	90	2	15385547
Pubmed	SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.	SPPL2A SPPL2C	6.59e-05	5	90	2	16829952
Pubmed	MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation.	SKP2 CDH1	6.59e-05	5	90	2	25651564
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH6 DNAH7	6.59e-05	5	90	2	39056782
Pubmed	Novel class of polytopic proteins with domains associated with putative protease activity.	SPPL2A SPPL2C	6.59e-05	5	90	2	12139484
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP4 SORL1	6.59e-05	5	90	2	19047013
Pubmed	Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.	ECT2 CDH1	6.59e-05	5	90	2	22750944
Pubmed	The dual effects of Cdh1/APC in myogenesis.	SKP2 CDH1	6.59e-05	5	90	2	17601983
Pubmed	Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.	ACTR8 ATR	6.59e-05	5	90	2	29759113
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD2	6.59e-05	5	90	2	22228765
Pubmed	Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.	GSPT2 GSPT1	6.59e-05	5	90	2	14685257
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	DOCK1 VANGL1 PGAM4 PLD2	8.65e-05	89	90	4	27034005
Pubmed	Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.	VANGL1 CDH1	9.87e-05	6	90	2	28599846
Pubmed	Further analysis of the lens of ephrin-A5-/- mice: development of postnatal defects.	EPHA2 CDH1	9.87e-05	6	90	2	23401654
Pubmed	Planar cell polarity governs the alignment of the nasopharyngeal epithelium in mammals.	VANGL1 CDH1	9.87e-05	6	90	2	32452625
Pubmed	Identification and characterization of TMEM16E and TMEM16F genes in silico.	ANO6 ANO5	9.87e-05	6	90	2	15067359
Pubmed	D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.	DRD2 GNAL	9.87e-05	6	90	2	17194762
Pubmed	RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry.	ATR RAET1G	9.87e-05	6	90	2	23166357
Pubmed	Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.	ATR CDH1	9.87e-05	6	90	2	20424596
Pubmed	The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.	GSPT2 GSPT1	9.87e-05	6	90	2	10358005
Pubmed	Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells.	SKP2 CDH1	9.87e-05	6	90	2	20717963
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	ACE2 SPPL2A FCGBP ANO6 PGAM4 GBE1 NID1 GNAL CDH1 LRG1 B3GNT8	1.00e-04	1070	90	11	23533145
Pubmed	Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia.	ANO5 DMD	1.38e-04	7	90	2	17418107
Pubmed	ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.	ANO6 ANO5	1.38e-04	7	90	2	22075693
Pubmed	Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.	ATR SKP2	1.38e-04	7	90	2	20818375
Pubmed	Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.	SPPL2A SPPL2C	1.38e-04	7	90	2	17965014
Pubmed	Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.	NRXN3 NXPH1	1.38e-04	7	90	2	9856994
Pubmed	The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory.	SKP2 CDH1	1.38e-04	7	90	2	19160489
Pubmed	Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes.	NPR2 PRPH2	1.38e-04	7	90	2	10493779
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SETD5 SYNE1 BRINP2 DNAH6	1.47e-04	102	90	4	11214970
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	WDR11 EPHA2 MIOS PSMD1 NID1 DMD	1.67e-04	313	90	6	38270169
Pubmed	Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development.	NID1 CDH1	1.84e-04	8	90	2	16505993
Pubmed	HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.	PTPRB CDH1	1.84e-04	8	90	2	24965120
Pubmed	Expression and function of epithelial anoctamins.	ANO6 ANO5	1.84e-04	8	90	2	20056604
Pubmed	Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.	NID1 CDH1	1.84e-04	8	90	2	24760005
Pubmed	Anoctamins are a family of Ca2+-activated Cl- channels.	ANO6 ANO5	1.84e-04	8	90	2	22946059
Pubmed	A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.	NID1 CDH1	1.84e-04	8	90	2	27354375
Pubmed	Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors.	SKP2 CDH1	1.84e-04	8	90	2	26474281
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PRKD2 RANBP2 VANGL1 EPHA2 TM9SF3 PSMD1 NID1 PLD2 DMD SORL1	2.14e-04	974	90	10	28675297
Pubmed	Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.	ATR CDH1	2.36e-04	9	90	2	20975950
Pubmed	Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.	GPR158 DMD	2.36e-04	9	90	2	30282023
Pubmed	Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing.	GSPT2 GSPT1	2.36e-04	9	90	2	21726813
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RANBP2 PSMD1	2.36e-04	9	90	2	9733766
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO6 ANO5	2.94e-04	10	90	2	23532839
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO6 ANO5	2.94e-04	10	90	2	19015192
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO6 ANO5	2.94e-04	10	90	2	24692353
Pubmed	Integral and associated lysosomal membrane proteins.	SPPL2A WDR11 MIOS SPG11	3.30e-04	126	90	4	17897319
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PRKD3 ANO6 VANGL1 EPHA2 MIOS SPG11 RAB29	3.41e-04	504	90	7	34432599
Pubmed	GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.	NPR2 OTOF	3.59e-04	11	90	2	30275816
Pubmed	Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.	LRP4 CDH1	3.59e-04	11	90	2	20454682
Pubmed	The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.	VANGL1 CDH1	3.59e-04	11	90	2	26517967
Pubmed	Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.	NID1 CDH1	3.59e-04	11	90	2	17023412
Pubmed	The OSBP-related protein family in humans.	OSBPL7 OSBPL6	3.59e-04	11	90	2	11483621
Pubmed	A family of 12 human genes containing oxysterol-binding domains.	OSBPL7 OSBPL6	4.30e-04	12	90	2	11735225
Pubmed	Acetylation-dependent regulation of Skp2 function.	SKP2 CDH1	4.30e-04	12	90	2	22770219
Pubmed	An oxysterol-binding protein family identified in the mouse.	OSBPL7 OSBPL6	4.30e-04	12	90	2	12215260
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	ANO6 VANGL1 EPHA2 SRGAP2 DMD IL1RAP	4.51e-04	377	90	6	38117590
Pubmed	A panel of sputum-based genomic marker for early detection of lung cancer.	SKP2 HYAL2	5.07e-04	13	90	2	20864512
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	RANBP2 ATR DNAJC9 DNAJC21	5.61e-04	145	90	4	28846114
Pubmed	The DNA sequence, annotation and analysis of human chromosome 3.	DNAH12 SETD5 HYAL2	5.67e-04	62	90	3	16641997
Pubmed	Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.	VANGL1 CDH1	5.91e-04	14	90	2	39225402
Pubmed	Cell-fate transition and determination analysis of mouse male germ cells throughout development.	ATR CDH1	5.91e-04	14	90	2	34824237
Pubmed	Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.	GSPT2 GSPT1	5.91e-04	14	90	2	16452507
GeneFamily	Dyneins, axonemal	DNAH12 DNAH17 DNAH6 DNAH7	2.36e-07	17	59	4	536
GeneFamily	Anoctamins	ANO6 ANO5	4.63e-04	10	59	2	865
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL7 OSBPL6	6.77e-04	12	59	2	670
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 DNAH12 SYNE1 OSBPL6 DMD DNAH6 DNAH7	1.52e-07	197	90	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	AKAP6 DNAH12 SYNE1 DMD DNAH6 DNAH7	2.66e-06	193	90	6	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FCGBP SYNE1 OSBPL7 GAL3ST4 B3GNT8 ZNF445	2.74e-06	194	90	6	58046894446cb250814252a23f60fdd59c114d77
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DNAH12 SYNE1 OSBPL6 CDH1 DNAH6 DNAH7	2.82e-06	195	90	6	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DNAH12 SYNE1 OSBPL6 CDH1 DNAH6 DNAH7	2.82e-06	195	90	6	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MEP1A ABHD15 GPR158 ANO5 FAM186B	2.84e-06	109	90	5	0d4128af237afcc0adb4dfdd206fa3ddbe5b0e86
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Interneuron\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	NRXN3 DNAH12 NXPH1 BRINP2	8.68e-06	64	90	4	fefabdf8d72a8f3caf78eb79d759edb475bdb2ad
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NRXN3 RNF146 ANO5 SNX21 ECT2	1.18e-05	146	90	5	1e81ad3d6d5d5ad2f0176d2a9593a954d38fa294
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO6 GAL3ST4 SFI1 PLD2 ECT2	1.68e-05	157	90	5	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO6 GAL3ST4 SFI1 PLD2 ECT2	2.01e-05	163	90	5	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO6 GAL3ST4 SFI1 PLD2 ECT2	2.01e-05	163	90	5	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	normal-na-Lymphocytic_NK-natural_killer_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	SPTBN5 OTOF SYNE1 OSBPL7 HYAL2	2.53e-05	171	90	5	d339840626211a7bf1a9eb8f14d6c9509ab05e1c
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ATR VANGL1 SYNE1 OCA2 RAB29	2.60e-05	172	90	5	68fd03f2c8ee01fe46194400f74ede3830e00f34
ToppCell	Ciliated_cells-A-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	AKAP6 DNAH12 OSBPL6 DNAH6 DNAH7	2.91e-05	176	90	5	1c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMIM9 NRXN3 PTPRB LRG1 HYAL2	3.07e-05	178	90	5	5cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCell	facs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMIM9 NRXN3 PTPRB LRG1 HYAL2	3.07e-05	178	90	5	f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK1 NXPH1 LRP4 GAL3ST4 IL1RAP	3.41e-05	182	90	5	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK1 NXPH1 LRP4 GAL3ST4 IL1RAP	3.41e-05	182	90	5	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 EXOC6B GBE1 ANO5 DMD	4.51e-05	193	90	5	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	RANBP2 ACTR8 ATR VANGL1 GSPT1	4.51e-05	193	90	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH12 SYNE1 OSBPL6 DNAH6 DNAH7	4.51e-05	193	90	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 DNAH12 SYNE1 DNAH6 DNAH7	4.62e-05	194	90	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Secretory\|World / shred by cell class for bronchial biopsy	FCGBP TM9SF3 LRP4 PSMD1 SORL1	4.74e-05	195	90	5	52f8281fe0df67cec3faa780a23ed6343ed5a6ba
ToppCell	mLN-T_cell-gd_T\|T_cell / Region, Cell class and subclass	PRKD3 ABHD15 DNAH12 ASB16 GNAL	4.85e-05	196	90	5	8f476408cd5a4ea9d25c763c66565343d7989b38
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH12 SYNE1 OSBPL6 DNAH6 DNAH7	4.97e-05	197	90	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NRXN3 EPHA2 ST3GAL1 CDH1 LRG1	4.97e-05	197	90	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ANO6 EPHA2 ST3GAL1 IL1RAP LRG1	4.97e-05	197	90	5	d8355f07a53e771052f9ab6b38814365dfe8d9ae
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	NRXN3 EPHA2 ST3GAL1 CDH1 LRG1	5.09e-05	198	90	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	NRXN3 EPHA2 ST3GAL1 CDH1 LRG1	5.22e-05	199	90	5	0447f8f53389fe7c6ddc04a97d86e74122ea16f4
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	GSPT2 SYNE1 LRP4 NID1 DMD	5.22e-05	199	90	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	TM9SF3 GBE1 DNAJC21 ZNFX1 GSPT1	5.34e-05	200	90	5	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GSPT2 GPR158 LRP4 NID1 DMD	5.34e-05	200	90	5	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 PGAM4 GNAL RAB29	9.65e-05	118	90	4	5f72022f4be3fb7ccec86dc05d37572833028886
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 PGAM4 GNAL RAB29	9.65e-05	118	90	4	053c0986051e36fdc4c48b8067c137b6299b2f1b
ToppCell	Control-Lymphoid_T/NK-NK_activated\|Control / Disease group, lineage and cell class	SYNE1 PGAM4 GNAL RAB29	9.97e-05	119	90	4	a258d91ac90d4174b6f203d7f96ba6e57c6003e7
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 PGAM4 GNAL RAB29	9.97e-05	119	90	4	28d6b0e9dda2fe4ca94ae9b95b7261618d0d9877
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 PGAM4 GNAL RAB29	9.97e-05	119	90	4	0fdd5b093ac20a4bda0f7b623808eb3ad0bf68e2
Drug	Betaxolol hydrochloride [63659-19-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	DRD2 NRXN3 PTPRB GAL3ST4 NID1 DMD VPS53	1.16e-05	195	89	7	5669_UP
Drug	Lisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; HL60; HG-U133A	TNK1 ATR CD2BP2 SPATA20 PLD2 ECT2 RAB29	1.19e-05	196	89	7	2046_UP
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; PC3; HT_HG-U133A	AKAP6 PTPRB OSBPL7 MIOS GAL3ST4 GNAL TRAF3IP3	1.32e-05	199	89	7	4076_UP
Drug	Lobeline alpha (-) hydrochoride [134-63-4]; Down 200; 10.6uM; PC3; HT_HG-U133A	PRKD3 NRXN3 SYNE1 EXOC6B SFI1 IL1RAP DNAH7	1.32e-05	199	89	7	5784_DN
Disease	Drug habituation	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0013170
Disease	Substance-Related Disorders	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0236969
Disease	Drug abuse	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0013146
Disease	Drug Use Disorders	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0013222
Disease	Drug Dependence	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C1510472
Disease	Substance Dependence	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0038580
Disease	Substance Use Disorders	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C0029231
Disease	Prescription Drug Abuse	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.36e-05	115	87	5	C4316881
Disease	Substance abuse problem	DOCK1 DRD2 NRXN3 WDR11 SYNE1	2.46e-05	116	87	5	C0740858
Disease	gait measurement	AKAP6 DRD2 NRXN3 SETD5 GNAL	8.39e-05	150	87	5	EFO_0007680
Disease	dystonia (implicated_via_orthology)	KCNU1 GNAL	5.56e-04	12	87	2	DOID:543 (implicated_via_orthology)
Disease	Benign neoplasm of stomach	ATR CDH1	1.14e-03	17	87	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR CDH1	1.14e-03	17	87	2	C0496905
Disease	Carcinoma in situ of stomach	ATR CDH1	1.14e-03	17	87	2	C0154060
Disease	Malignant neoplasm of breast	AKAP6 OTOF SYNE1 DNAJC21 OCA2 PLD2 DMD ECT2 CDH1 SORL1	1.24e-03	1074	87	10	C0006142
Disease	Stomach Carcinoma	ATR CDH1	1.74e-03	21	87	2	C0699791
Disease	short-term memory	DRD2 DNAH12 NXPH1	1.92e-03	83	87	3	EFO_0004335
Disease	infant body height	MTMR11 ZNFX1	2.09e-03	23	87	2	EFO_0006785
Disease	traumatic brain injury (biomarker_via_orthology)	DRD2 GNAL	2.27e-03	24	87	2	DOID:0081292 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQYDKDRWLSTQWRL	VANGL1	451	Q8TAA9
WICDQNLSDLYRWLQ	LRG1	301	P02750
WKQRQARLEYEWDLV	ANO5	401	Q75V66
IWCYLREESEADQWL	CCSMST1	91	Q4G0I0
DTTQELWIYQREWQR	ACTR8	596	Q9H981
EWLEWEDRRRAAAQQ	ASB16	21	Q96NS5
LWRIRWEELQFGNSE	NPR2	491	P20594
WKEDNALWERDRNLL	CCDC70	136	Q6NSX1
WNLEDLAREQQRRWV	FAM186B	521	Q8IYM0
RWIEFCQLLSERLNW	DMD	811	P11532
NANWTWYLRATLDVA	CD1B	256	P29016
SWDTYWDRNDPLRDV	ABHD15	331	Q6UXT9
ERAKLYRWDRDVSQW	RANBP2	2936	P49792
SWEDSSADWERRYLL	OCA2	126	Q04671
WSDYEIVRLQLWDIA	RAB29	51	O14966
EWIYKAWERRNEQDF	ECT2	241	Q9H8V3
WKRRQAELEYEWDTV	ANO6	396	Q4KMQ2
DWTDYNDFELQWLPR	PTPRB	1286	P23467
WVRNWQDKDVYRRLS	HYAL2	141	Q12891
LQLSVWDWDLRYSNA	MTMR11	511	A4FU01
WDWDLRYSNAQILQF	MTMR11	516	A4FU01
QDDLDWYQALVWSLL	GPR158	151	Q5T848
LTLIWYWTRQDRDLE	IL1RAP	66	Q9NPH3
NRETWYLSWALDTNQ	GSPT2	246	Q8IYD1
ADSDYLWRSLSLQRW	FBXW12	36	Q6X9E4
EETDWYLLNLFRLWW	PCYOX1L	121	Q8NBM8
TDSVRGNLYWTDWNR	NID1	1071	P14543
QWARYLRWDASTRSD	NRXN3	36	Q9Y4C0
WLAQLRYYWENENAR	DNAH12	1191	Q6ZR08
WLQEYQTWLDLRELE	PRKD2	806	Q9BZL6
WLQDYQTWLDLREFE	PRKD3	831	O94806
SLDYLQREWRFLWNF	KCNU1	756	A8MYU2
WNLENRFSCWYDADL	PGAM4	16	Q8N0Y7
RQLLDLFIQWDWSTY	EXOC6B	731	Q9Y2D4
WKEEYDTRQASNRWE	DNAJC21	166	Q5F1R6
TARARAWNNLDWALY	GAL3ST4	356	Q96RP7
QREAWVSNDTYWELR	OSBPL6	906	Q9BZF3
WYLSWALDTNQEERD	GSPT1	121	P15170
SLDLFESIWNNRWLR	GNAL	256	P38405
RDAQIRDSWLDNIDW	CD2BP2	111	O95400
RIFLEWRTAVYNWAL	ATR	646	Q13535
FDWQRQLRYYWDIDL	DNAH6	1406	Q9C0G6
RFLLSNIRWWLEEYR	GBE1	336	Q04446
LREWSTIWRQLYVQD	DOCK1	96	Q14185
WYADLLLRIRELEAW	DNAH17	4296	Q9UFH2
LQVSYDWNWRVDVTL	FCGBP	4191	Q9Y6R7
DQDNWLRTNWVYRGE	EPHA2	76	P29317
ELLRQWLDHWNWYDL	DNAH7	2061	Q8WXX0
LDYNERLWAWESWRS	ACE2	156	Q9BYF1
LTQDRDWEAYWRLLF	DNAJC9	91	Q8WXX5
LSWYDDDLERQNWSR	DRD2	6	P14416
WESRRYSDLLLWDFL	B3GNT8	201	Q7Z7M8
ITYRIWRDTANWLEI	CDH1	521	P12830
LEEWWLNVAYLDVRI	CROT	81	Q9UKG9
SWWPDQRRRLYNANI	OTOF	716	Q9HC10
EWWVTNNTYWRLRAE	OSBPL7	816	Q9BZF2
IYFCDWQQAWERRES	SFI1	321	A8K8P3
NEIYWDDWSQLSIFR	SORL1	971	Q92673
ETWRLWQKFLDDYSR	SYNE1	7996	Q8NF91
PYSEQDLWDWLRNST	NXPH1	81	P58417
YEQRLQDQSLWWIFV	RHBDL3	361	P58872
DRDDYVNIWWDQILS	MEP1A	171	Q16819
LRDNLEWLARATNWA	PSMD1	386	Q99460
YRNEDRWAWLLQDTL	SPPL2C	341	Q8IUH8
WENRIRLWTDQYEEA	SETD5	206	Q9C0A6
ALLEDDTYRWWLRLQ	ST3GAL1	91	Q11201
RNGWWQYDERTSREL	RNF146	111	Q9NTX7
RQRLEQAEAWLACWE	SPTBN5	3426	Q9NRC6
ERSLSYWWNRIQSLL	BRINP2	411	Q9C0B6
LLDFDSEYQELWDWL	AKAP6	961	Q13023
RWYRLASDESLWQTL	SKP2	126	Q13309
EALWRYLTARHDWLN	SPG11	881	Q96JI7
EEWRSQYEALKEDWR	TRAF3IP3	316	Q9Y228
EWQLLDCAERTLYWD	ZNF684	21	Q5T5D7
WIENYRNLLDAWRFW	MIOS	696	Q9NXC5
RSWLNNFRDYLWQLI	SMIM9	51	A6NGZ8
FRDWFEIQWISNRYL	PRPH2	171	P23942
SQESAWLEWALRLQD	SPATA20	591	Q8TB22
YREALALWANAWQLQ	SNX21	256	Q969T3
FRNEDRWAWILQDIL	SPPL2A	306	Q8TCT8
LLYQRASDDWWEGRH	SRGAP2	756	O75044
WLLRRVLWSDSYQIA	RAET1G	271	Q6H3X3
DFSQDEWEWLNLAQR	ZNF470	31	Q6ECI4
QDVAWLDKIDRRYAW	VPS53	276	Q5VIR6
DVWQLDLSSRWQLYR	ZNFX1	921	Q9P2E3
DLSSRWQLYRLWLQL	ZNFX1	926	Q9P2E3
LLNAEDYRWQWTSFL	TM9SF3	506	Q9HD45
DEWGWLDSAQRNLYR	ZNF445	246	P59923
RADCWRILEHYQWDL	TNK1	641	Q13470
WLWNQDASRDLLLAI	WDR11	121	Q9BZH6
YRQARWWAQEITELA	PLD2	296	O14939
WEEWNLLSEAQRCLY	ZNF814	26	B7Z6K7
DWVARNLYWTDTGRN	LRP4	1436	O75096