Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PPP1R3B PLCXD2 XRN2 NT5M	1.92e-03	807	14	4	GO:0016788
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PPP1R3B PLCXD2 NT5M	2.23e-03	386	14	3	GO:0042578
GeneOntologyBiologicalProcess	transition between fast and slow fiber	GTF2IRD2 GTF2IRD2B	3.32e-05	13	14	2	GO:0014883
GeneOntologyBiologicalProcess	regulation of skeletal muscle adaptation	GTF2IRD2 GTF2IRD2B	8.07e-05	20	14	2	GO:0014733
GeneOntologyBiologicalProcess	skeletal muscle adaptation	GTF2IRD2 GTF2IRD2B	2.10e-04	32	14	2	GO:0043501
GeneOntologyBiologicalProcess	mRNA cis splicing, via spliceosome	PRPF39 PRPF40A	4.54e-04	47	14	2	GO:0045292
GeneOntologyBiologicalProcess	glycogen biosynthetic process	GBE1 PPP1R3B	6.22e-04	55	14	2	GO:0005978
GeneOntologyBiologicalProcess	glucan biosynthetic process	GBE1 PPP1R3B	6.22e-04	55	14	2	GO:0009250
GeneOntologyBiologicalProcess	striated muscle adaptation	GTF2IRD2 GTF2IRD2B	1.09e-03	73	14	2	GO:0014888
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	GBE1 PPP1R3B	1.18e-03	76	14	2	GO:0000271
GeneOntologyCellularComponent	U2-type prespliceosome	PRPF39 PRPF40A	6.33e-05	18	14	2	GO:0071004
GeneOntologyCellularComponent	prespliceosome	PRPF39 PRPF40A	6.33e-05	18	14	2	GO:0071010
GeneOntologyCellularComponent	U1 snRNP	PRPF39 PRPF40A	2.17e-04	33	14	2	GO:0005685
GeneOntologyCellularComponent	spliceosomal snRNP complex	PRPF39 PRPF40A	1.83e-03	96	14	2	GO:0097525
GeneOntologyCellularComponent	U2-type spliceosomal complex	PRPF39 PRPF40A	1.87e-03	97	14	2	GO:0005684
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	PRPF39 PRPF40A	2.27e-03	107	14	2	GO:0030532
GeneOntologyCellularComponent	Sm-like protein family complex	PRPF39 PRPF40A	2.80e-03	119	14	2	GO:0120114
MousePheno	abnormal mean corpuscular volume	CYBB PRPF39 PRPF40A CSNK1G2	9.11e-05	487	8	4	MP:0000226
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.68e-06	4	13	2	PS51139
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.68e-06	4	13	2	IPR004212
Domain	-	GTF2IRD2 GTF2IRD2B	2.68e-06	4	13	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2 GTF2IRD2B	2.68e-06	4	13	2	PF02946
Domain	RNaseH-like_dom	GTF2IRD2 GTF2IRD2B	1.02e-03	69	13	2	IPR012337
Domain	Ser/Thr_kinase_AS	CSNK1G2 LIMK2	2.47e-02	357	13	2	IPR008271
Domain	PROTEIN_KINASE_ST	CSNK1G2 LIMK2	2.54e-02	362	13	2	PS00108
Domain	Protein_kinase_ATP_BS	CSNK1G2 LIMK2	2.76e-02	379	13	2	IPR017441
Domain	Pkinase	CSNK1G2 LIMK2	2.79e-02	381	13	2	PF00069
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	1.50e-07	2	14	2	15388857
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2 GTF2IRD2B	4.51e-07	3	14	2	15100712
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2 GTF2IRD2B	9.02e-07	4	14	2	21328569
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2 GTF2IRD2B	9.02e-07	4	14	2	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2 GTF2IRD2B	9.02e-07	4	14	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2 GTF2IRD2B	9.02e-07	4	14	2	22899722
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	GTF2IRD2 GTF2IRD2B	2.56e-05	19	14	2	30228200
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	GBE1 PRPF40A XRN2	8.63e-05	220	14	3	35785414
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	PRPF39 PRPF40A XRN2	1.65e-04	274	14	3	34244482
Pubmed	Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.	PRPF40A XRN2	1.97e-04	52	14	2	24591637
Interaction	GTF2IRD2 interactions	GTF2IRD2 GTF2IRD2B	2.53e-05	12	13	2	int:GTF2IRD2
Interaction	GTF2IRD2B interactions	GTF2IRD2 GTF2IRD2B	4.01e-05	15	13	2	int:GTF2IRD2B
Cytoband	7q11.23	GTF2IRD2 GTF2IRD2B	3.95e-04	97	14	2	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	GTF2IRD2 GTF2IRD2B	3.01e-03	271	14	2	chr7q11
Drug	NSC294864	GTF2IRD2 GTF2IRD2B LIMK2	9.59e-06	75	13	3	CID000325714
Disease	obsolete_red blood cell distribution width	GTF2IRD2 CSNK1G2 GTF2IRD2B LIMK2 XRN2	1.19e-04	1347	12	5	EFO_0005192
Disease	Liver Cirrhosis, Experimental	CYBB PPP1R3B LIMK2	3.31e-03	774	12	3	C0023893
Disease	retinal vasculature measurement	GBE1 XRN2	1.80e-02	517	12	2	EFO_0010554

Protein segments in the cluster

Peptide	Gene	Start	Entry
YYEKDGKLYCPKDYW	LIMK2	51	P53671
LYWKDPEYAKYLKYP	MED31	56	Q9Y3C7
FVFDYEYDWAGKPLP	CSNK1G2	321	P78368
PYCYGYWKKYADLEK	PRPF39	126	Q86UA1
PWKEYKSDSGKPYYY	PRPF40A	186	O75400
GWNPFSYPYKKLDYG	GBE1	106	Q04446
FVWYYRVYDIPPKFF	CYBB	26	P04839
GIPEFYKYLWGSYPK	GTF2IRD2	886	Q86UP8
GIPEFYKYLWGSYPK	GTF2IRD2B	886	Q6EKJ0
YGLFPEWPSYLGYEK	PPP1R3B	266	Q86XI6
YEKYAWVEKYFGPDF	NT5M	141	Q9NPB1
IFYHCPFYKQYPFLW	PLCXD2	211	Q0VAA5
KWYYPFHYAPFASDF	XRN2	561	Q9H0D6
FDYFLWYKKYPAEGP	TRAV29DV5	56	P04437