Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10B ALG10	2.49e-06	2	32	2	GO:0106073
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS2R13 TAS2R60 OR2L3 PTGDR2 OR1S1 ADGRA3 HRH3 GPR75 OR2AJ1	7.01e-06	884	32	9	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TAS2R13 TAS2R60 OR2L3 PTGDR2 OR1S1 ADGRA3 HRH3 GPR75 OR2AJ1 TMEM63A	3.21e-05	1353	32	10	GO:0004888
GeneOntologyMolecularFunction	glucosyltransferase activity	ALG10B ALG10	5.63e-04	22	32	2	GO:0046527
GeneOntologyMolecularFunction	calcium-activated cation channel activity	KCNU1 TMEM63A	8.52e-04	27	32	2	GO:0005227
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R13 TAS2R60	8.52e-04	27	32	2	GO:0033038
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNU1 TMEM63A	1.12e-03	31	32	2	GO:0022839
GeneOntologyMolecularFunction	taste receptor activity	TAS2R13 TAS2R60	1.27e-03	33	32	2	GO:0008527
GeneOntologyMolecularFunction	transmembrane transporter activity	ABCG4 SPNS1 SLC9A3 KCNU1 SLCO6A1 SLC6A19 TMEM63A	2.26e-03	1180	32	7	GO:0022857
GeneOntologyMolecularFunction	transporter activity	ABCG4 SPNS1 SLC9A3 KCNU1 SLCO6A1 SLC6A19 TMEM63A	3.71e-03	1289	32	7	GO:0005215
GeneOntologyMolecularFunction	hexosyltransferase activity	TMTC1 ALG10B ALG10	4.60e-03	211	32	3	GO:0016758
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	TAS2R13 TAS2R60 OR2L3 LMBRD2 PTGDR2 OR1S1 ADGRA3 HRH3 GPR75 OR2AJ1	3.16e-05	1395	32	10	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus	TAS2R13 TAS2R60 LY96 OR2L3 OR1S1 OR2AJ1	1.35e-04	524	32	6	GO:0009593
Domain	Alg10	ALG10B ALG10	2.67e-06	2	31	2	IPR016900
Domain	DIE2_ALG10	ALG10B ALG10	2.67e-06	2	31	2	PF04922
Domain	HAT	PDCD11 TMTC1	1.19e-04	10	31	2	IPR003107
Domain	HAT	PDCD11 TMTC1	1.19e-04	10	31	2	SM00386
Domain	7tm_1	OR2L3 PTGDR2 OR1S1 HRH3 GPR75 OR2AJ1	7.52e-04	677	31	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2L3 PTGDR2 OR1S1 HRH3 GPR75 OR2AJ1	8.00e-04	685	31	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2L3 PTGDR2 OR1S1 HRH3 GPR75 OR2AJ1	8.37e-04	691	31	6	PS50262
Domain	GPCR_Rhodpsn	OR2L3 PTGDR2 OR1S1 HRH3 GPR75 OR2AJ1	8.44e-04	692	31	6	IPR000276
Domain	TAS2R	TAS2R13 TAS2R60	8.45e-04	26	31	2	PF05296
Domain	T2R	TAS2R13 TAS2R60	8.45e-04	26	31	2	IPR007960
Domain	GPCR_Rhodpsn_7TM	OR2L3 PTGDR2 OR1S1 HRH3 GPR75	4.59e-03	670	31	5	IPR017452
Pathway	WP_GPCRS_ODORANT	TAS2R13 TAS2R60 PTGDR2 ADGRA3 GPR75	7.13e-06	157	25	5	MM15872
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	ALG10B ALG10	1.64e-04	11	25	2	M47614
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10B ALG10	2.95e-06	3	35	2	24303013
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10B ALG10	5.90e-06	4	35	2	14525949
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R13 TAS2R60	2.24e-04	22	35	2	12734386
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R13 TAS2R60	2.46e-04	23	35	2	20022913
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10B ALG10	2.46e-04	23	35	2	12955145
Pubmed	Receptors for bitter and sweet taste.	TAS2R13 TAS2R60	2.91e-04	25	35	2	12139982
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	TRIM11 EPB41L3 CDC42BPB	2.92e-04	128	35	3	23858473
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R13 TAS2R60	3.15e-04	26	35	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R13 TAS2R60	3.40e-04	27	35	2	12581520
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R13 TAS2R60	3.66e-04	28	35	2	15744053
Pubmed	Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs.	FAM106C FAM106A	3.93e-04	29	35	2	11997339
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R13 TAS2R60	4.20e-04	30	35	2	12679530
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R13 TAS2R60	5.41e-04	34	35	2	15496549
Cytoband	1q42.13	TMEM78 TRIM11	6.49e-04	49	35	2	1q42.13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q42	TMEM78 TRIM11 TMEM63A	8.16e-04	240	35	3	chr1q42
Cytoband	Ensembl 112 genes in cytogenetic band chr12p11	TMTC1 ALG10	1.94e-03	85	35	2	chr12p11
Cytoband	1q44	OR2L3 OR2AJ1	3.21e-03	110	35	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2L3 OR2AJ1	4.32e-03	128	35	2	chr1q44
Cytoband	17p11.2	FAM106C FAM106A	6.58e-03	159	35	2	17p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr17p11	FAM106C FAM106A	1.05e-02	203	35	2	chr17p11
Cytoband	Ensembl 112 genes in cytogenetic band chr5p15	SLC9A3 SLC6A19	1.06e-02	204	35	2	chr5p15
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10B ALG10	1.69e-06	2	24	2	448
GeneFamily	Taste 2 receptors	TAS2R13 TAS2R60	1.21e-03	39	24	2	1162
GeneFamily	Olfactory receptors, family 2	OR2L3 OR2AJ1	9.77e-03	113	24	2	149
GeneFamily	Solute carriers	SLC9A3 SLCO6A1 SLC6A19	1.49e-02	395	24	3	752
Disease	Long Qt Syndrome 2	ALG10B ALG10	3.20e-06	3	31	2	C3150943
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10B ALG10	1.60e-05	6	31	2	DOID:0050563 (implicated_via_orthology)
Disease	leptin measurement	ALG10B ALG10	3.29e-03	81	31	2	EFO_0005000
Disease	lung disease severity measurement	MMP27 NHSL2	6.84e-03	118	31	2	EFO_0007744
Disease	hypertension (implicated_via_orthology)	SLC9A3 HRH3	8.00e-03	128	31	2	DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLFSGFFVSFKTIPT	ABCG4	546	Q9H172
VFSFVFGATSLSFSA	ADGRA3	1026	Q8IWK6
RFSFAFSFPRGTLSI	FAM106A	56	Q4KMX7
LFTTLAFPVSTFVFL	ADTRP	86	Q96IZ2
SFTLFFSFPHLLSPS	ALG10B	296	Q5I7T1
FLFSFQLPPTLVTSF	ARRDC2	106	Q8TBH0
GTVFLSTTIFLVFPF	OR2L3	196	Q8NG85
LLFLFFITFSSAFPL	MMP27	6	Q9H306
RFSFAFSFPRGTLSI	FAM106C	56	P0CH98
GLSVIIFPFTLSFFS	OR1S1	216	Q8NH92
ALGISFTFFGTSFLF	INPP5E	406	Q9NRR6
AFILSSFVTFFSGLI	KCNU1	26	A8MYU2
LPFIGFTFTTESCFS	CDC42BPB	396	Q9Y5S2
NFTLFLGLFFLTTPS	TMEM63A	426	O94886
SDLLASASLPFFTYF	PTGDR2	76	Q9Y5Y4
FTFVLFFSSASSIPD	GPR75	101	O95800
EFFTPFLSVTFFNLS	HRH3	206	Q9Y5N1
MLPFLFFSTLFSSIF	LY96	1	Q9Y6Y9
FFLLSASFSVPYALT	EPB41L3	641	Q9Y2J2
FSIASFFPAFITLLF	FAM8A1	376	Q9UBU6
GLFSSSPTSVVFFLV	OR2AJ1	16	Q8NGZ0
FSLTPFTVAFISFLL	TAS2R13	186	Q9NYV9
FSSVGLSSFTTILFF	TAS2R60	146	P59551
FFSFSLAFGGLISFS	SLC6A19	276	Q695T7
TFFSTTPVLSLFAVF	LMBRD2	406	Q68DH5
SLVFTPFASSSDAFF	NHSL2	946	Q5HYW2
ASFTLTPTVFFFYLL	SLC9A3	106	P48764
FIAFIFSTLIFSGFS	SLCO6A1	581	Q86UG4
SFTLFFSFPHLLSPS	ALG10	296	Q5BKT4
VTPFGLTLNFLTFFT	PDCD11	291	Q14690
SFYSATDGSLLFIFP	TRIM11	416	Q96F44
FPSTVSPFFLLLSLF	TMTC1	196	Q8IUR5
PSFVLSSLGFTAVAF	SPNS1	271	Q9H2V7
FPVITGSLFVLTFFS	ZDHHC19	61	Q8WVZ1
PAFLSFSTSFSFFLS	TMEM78	56	Q5T7P6
FSTSFSFFLSFLPLS	TMEM78	61	Q5T7P6
SFFLSFLPLSLSLFL	TMEM78	66	Q5T7P6
LSLFLPFFPSFFLSL	TMEM78	76	Q5T7P6
FFLSLSLSPSFLPSF	TMEM78	86	Q5T7P6