Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainANK_REPEAT

MUC16 ANKRD30B SNCAIP PPP1R12A ANKS1A

2.29e-05253265PS50088
DomainANK_REP_REGION

MUC16 ANKRD30B SNCAIP PPP1R12A ANKS1A

2.33e-05254265PS50297
DomainAnk_2

ANKRD30B SNCAIP PPP1R12A ANKS1A

2.09e-04215264PF12796
DomainAnk

ANKRD30B SNCAIP PPP1R12A ANKS1A

2.62e-04228264PF00023
Domain-

ANKRD30B SNCAIP PPP1R12A ANKS1A

3.60e-042482641.25.40.20
DomainANK

ANKRD30B SNCAIP PPP1R12A ANKS1A

3.77e-04251264SM00248
DomainAnkyrin_rpt-contain_dom

ANKRD30B SNCAIP PPP1R12A ANKS1A

3.95e-04254264IPR020683
DomainAnkyrin_rpt

ANKRD30B SNCAIP PPP1R12A ANKS1A

4.44e-04262264IPR002110
DomainTUDOR

TDRKH KDM4C

4.63e-0423262PS50304
DomainTUDOR

TDRKH KDM4C

6.40e-0427262SM00333
DomainTudor

TDRKH KDM4C

7.91e-0430262IPR002999
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NUP133 PRRC2A LSG1 DROSHA TOP2B PPP1R12A

3.92e-0584727635850772
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NUP133 PRRC2A LSG1 TOP2B PPP1R12A ANKS1A

6.74e-0593427633916271
Pubmed

PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.

PRRC2A MBP

1.33e-042227238507412
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

MTFR2 LSG1 DROSHA TOP2B

1.71e-0436427424778252
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

PRRC2A LSG1 TOP2B PPP1R12A ZNF292

2.13e-0472427536232890
Pubmed

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.

PRRC2A TOP2B PPP1R12A

2.30e-0415427336490346
Pubmed

Dilated Cardiomyopathy Overview

LDB3 RBM20

2.84e-043227220301486
Pubmed

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

PRRC2A MBP HECTD4

3.30e-0417427335031058
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

NUP133 LSG1 TOP2B HECTD4

3.52e-0444027434244565
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NFE2L3 KDM4C PRRC2A DROSHA ZNF292 HECTD4

3.82e-04128527635914814
Pubmed

A comprehensive resource of interacting protein regions for refining human transcription factor networks.

LONRF3 PRRC2A PPP1R12A

4.33e-0419127320195357
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

NUP133 MTFR2 TOP2B ANKS1A

4.48e-0446927427634302
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

PRRC2A LSG1 TOP2B DMXL1

4.70e-0447527431040226
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

NFE2L3 ANKRD30B LSG1 TOP2B PPP1R12A ZNF292

7.03e-04144227635575683
CytobandEnsembl 112 genes in cytogenetic band chr5q23

SNCAIP DMXL1

2.17e-03117272chr5q23
GeneFamilyAnkyrin repeat domain containing

ANKRD30B SNCAIP PPP1R12A ANKS1A

8.27e-05242184403
GeneFamilyTudor domain containing

TDRKH KDM4C

6.11e-0437182780
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

LDB3 PRRC2A RBM20

5.16e-051202733b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MUC16 TDRKH MTFR2

9.82e-05149273a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MUC16 TDRKH MTFR2

1.00e-041502737a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

MUC16 RBM20 CFAP65

1.13e-0415627310d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

NUP133 ANKS1A HECTD4

1.35e-0416627332d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NFE2L3 MUC16 UNC13C

1.35e-04166273545f6c91102568791443717e522f89cb3bd1a070
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.38e-041672737abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.38e-04167273d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDB3 LONRF3 MIEF2

1.38e-04167273b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NFE2L3 MUC16 UNC13C

1.50e-041722739a256db817c1af1802203cc88a55d608fb328c63
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.53e-041732733725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

1.53e-04173273fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.53e-04173273ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

1.53e-04173273901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUP133 PPP1R12A ZNF292

1.58e-04175273a2adaa09f37e3db5d819e56ed402fe04b72abeb2
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUP133 PPP1R12A ZNF292

1.58e-0417527359a8481a3b4ed63b137baea25bc02f2078dc3ac7
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.66e-04178273c413861148129be1ee94f2ceb5999840217eebe5
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NFE2L3 MUC16 UNC13C

1.66e-04178273bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

MUC16 TDRKH MTFR2

1.69e-0417927368511e87b12b8253de7771e5ccfc5869248b8450
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NFE2L3 MUC16 UNC13C

1.72e-041802732ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C LDB3 PPP1R12A

1.95e-04188273d534ed9870405a3c1075962308f72b460aed17bf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

1.98e-041892732cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

1.98e-04189273127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

LDB3 RBM20 PPP1R12A

2.04e-041912732da83c493e60ad0278848957645277d76737a188
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD30B UNC13C SNCAIP

2.08e-04192273342842378c20267c5044bdd622515e8b9f895623
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LDB3 RBM20 PPP1R12A

2.11e-041932735ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SNCAIP KDM4C ZNF292

2.11e-041932739337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LDB3 RBM20 PPP1R12A

2.11e-041932735260ac95a15cc43a19909badad0c7e3854da920d
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L3 SNCAIP RBM20

2.11e-0419327355eab7d2574e9cc2ed8f08e0a7ca7cbf90fb5818
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

2.14e-04194273ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UNC13C RAB11FIP2 MBP

2.14e-0419427369bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UNC13C RAB11FIP2 MBP

2.14e-0419427304bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 RBM20 PPP1R12A

2.14e-041942735c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

SNCAIP ZNF292 HECTD4

2.20e-04196273721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

SNCAIP ZNF292 HECTD4

2.20e-0419627338da0751941adca650fe9b383d9f343153978eb5
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SNCAIP KDM4C ZNF292

2.24e-0419727357ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCelltumor_Lung-Fibroblasts-Smooth_muscle_cells|Fibroblasts / Location, Cell class and cell subclass

LDB3 RBM20 PPP1R12A

2.27e-04198273f540f464118edc0fb809ebcb813d0302e6952253
DiseasePrimary familial dilated cardiomyopathy

LDB3 RBM20

2.95e-0430252cv:C0340427
DiseasePrimary dilated cardiomyopathy

LDB3 RBM20

3.80e-0434252cv:C0007193
Diseaseresponse to antihypertensive drug

LDB3 HECTD4

5.54e-0441252EFO_0005405
Diseasedilated cardiomyopathy (is_implicated_in)

LDB3 RBM20

6.09e-0443252DOID:12930 (is_implicated_in)
DiseaseFamilial dilated cardiomyopathy

LDB3 RBM20

6.38e-0444252C0340427
DiseaseCardiomyopathy

LDB3 RBM20

7.28e-0447252cv:C0878544
DiseaseCoronary Arteriosclerosis

ANKS1A HECTD4

1.39e-0365252C0010054
DiseaseCoronary Artery Disease

ANKS1A HECTD4

1.39e-0365252C1956346
Diseaseforced expiratory volume

DROSHA RBM20 TOP2B ANKS1A

4.10e-03789254EFO_0004314
Diseasefactor VIII measurement, coronary artery disease

PRRC2A ANKS1A

4.12e-03113252EFO_0001645, EFO_0004630
Diseasevon Willebrand factor measurement, coronary artery disease

ANKS1A HECTD4

4.48e-03118252EFO_0001645, EFO_0004629
Diseasetea consumption measurement

KDM4C HECTD4

5.33e-03129252EFO_0010091
DiseaseCardiomyopathies

LDB3 RBM20

5.41e-03130252C0878544
Diseasewaist circumference

UNC13C PRRC2A HECTD4

5.53e-03429253EFO_0004342

Protein segments in the cluster

PeptideGeneStartEntry
FPSESKQKDDEENSW

ANKRD30B

561

Q9BXX2
KQKDDEENSWDSESP

ANKRD30B

566

Q9BXX2
KRLEKSPSFASEWDE

ANKS1A

656

Q92625
KLDAREDKSSAVDWS

DMXL1

1911

Q9Y485
SDPENTRTKKEQDWE

RBM20

876

Q5T481
EARATSDSWNEKEKS

MUC16

3861

Q8WXI7
SSNISKWELDDSSEK

NUP133

291

Q8WUM0
KSQNKPEDEADEWAR

LDB3

251

O75112
GPKEEDCSQDWKESS

LSG1

326

Q9H089
EESETSEEKSPNKWG

CFAP65

1651

Q6ZU64
KPDWEAEKTTESRNE

NFE2L3

236

Q9Y4A8
KPDSSNEENDARWET

KDM4C

656

Q9H3R0
SWKSEDSEGKSEDEP

HECTD4

2706

Q9Y4D8
DSKRTADPKNAWQDA

MBP

66

P02686
LDKDSSPKDDVWDSV

IFNGR2

306

P38484
KTEPKARSWDEALSD

PROCA1

16

Q8NCQ7
SPRDEDDTKADSWKE

MIEF2

56

Q96C03
EEEKDRWSDNQSSGK

DROSHA

366

Q9NRR4
KRNPWSDDESKSESD

TOP2B

1331

Q02880
WASKQEQSDPKSSDA

PRRC2A

86

P48634
KSQWKSPDADDDSVA

SNCAIP

571

Q9Y6H5
IKKNNWQSPDDSDED

UNC13C

441

Q8NB66
WEKPSDDSFQKSEAQ

TDRKH

271

Q9Y2W6
RSDAWDKSKAESAVT

ZNF292

886

O60281
KKNPFEESSETWDSS

RAB11FIP2

321

Q7L804
DDSFEKENRSWESSP

MTFR2

326

Q6P444
EEEEKWDATSPKAAS

LONRF3

396

Q496Y0
NRLWAEDSTEKEKDS

PPP1R12A

611

O14974