Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell adhesion molecule binding	TENM1 NLGN4X PTPRF TENM2 NLGN4Y SPTAN1 PKP4	3.08e-04	599	44	7	GO:0050839
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN4X NLGN4Y	5.58e-04	16	44	2	GO:0042043
GeneOntologyMolecularFunction	chloride ion binding	NLGN4X NLGN4Y	5.58e-04	16	44	2	GO:0031404
GeneOntologyBiologicalProcess	territorial aggressive behavior	NLGN4X NLGN4Y	1.33e-05	3	44	2	GO:0002124
GeneOntologyBiologicalProcess	male courtship behavior	NLGN4X NLGN4Y	2.66e-05	4	44	2	GO:0008049
GeneOntologyBiologicalProcess	courtship behavior	NLGN4X NLGN4Y	9.28e-05	7	44	2	GO:0007619
GeneOntologyBiologicalProcess	brainstem development	NLGN4X NLGN4Y	1.24e-04	8	44	2	GO:0003360
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN4X NLGN4Y	1.98e-04	10	44	2	GO:0097105
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN4X NLGN4Y	2.42e-04	11	44	2	GO:0097104
GeneOntologyBiologicalProcess	aggressive behavior	NLGN4X NLGN4Y	3.42e-04	13	44	2	GO:0002118
GeneOntologyBiologicalProcess	presynaptic membrane organization	NLGN4X NLGN4Y	3.42e-04	13	44	2	GO:0097090
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN4Y	2.83e-05	4	46	2	GO:0098983
GeneOntologyCellularComponent	symmetric synapse	NLGN4X NLGN4Y	3.64e-04	13	46	2	GO:0032280
GeneOntologyCellularComponent	postsynaptic density membrane	GRIK4 NLGN4X PTPRF NLGN4Y	3.91e-04	157	46	4	GO:0098839
GeneOntologyCellularComponent	postsynaptic density	CRTC1 GRIK4 NLGN4X PTPRF NLGN4Y PKP4	4.40e-04	451	46	6	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	CRTC1 GRIK4 NLGN4X PTPRF NLGN4Y PKP4	5.91e-04	477	46	6	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	CRTC1 GRIK4 NLGN4X PTPRF NLGN4Y PKP4	7.80e-04	503	46	6	GO:0099572
GeneOntologyCellularComponent	glycinergic synapse	NLGN4X NLGN4Y	8.78e-04	20	46	2	GO:0098690
GeneOntologyCellularComponent	neuron to neuron synapse	CRTC1 GRIK4 NLGN4X PTPRF NLGN4Y PKP4	9.55e-04	523	46	6	GO:0098984
GeneOntologyCellularComponent	postsynaptic specialization membrane	GRIK4 NLGN4X PTPRF NLGN4Y	9.87e-04	201	46	4	GO:0099634
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	NLGN4X NLGN4Y	1.27e-03	24	46	2	GO:0098985
GeneOntologyCellularComponent	postsynapse	CRTC1 GRIK4 NLGN4X PTPRF TENM2 NLGN4Y SPTAN1 PKP4	1.54e-03	1018	46	8	GO:0098794
GeneOntologyCellularComponent	excitatory synapse	NLGN4X PTPRF NLGN4Y	1.69e-03	107	46	3	GO:0060076
GeneOntologyCellularComponent	desmosome	DSG4 PKP4	1.73e-03	28	46	2	GO:0030057
GeneOntologyCellularComponent	postsynaptic membrane	GRIK4 NLGN4X PTPRF TENM2 NLGN4Y	1.90e-03	405	46	5	GO:0045211
GeneOntologyCellularComponent	glutamatergic synapse	CRTC1 GRIK4 PPP3CB NLGN4X TENM2 NLGN4Y SPTAN1	1.92e-03	817	46	7	GO:0098978
GeneOntologyCellularComponent	inhibitory synapse	NLGN4X NLGN4Y	2.12e-03	31	46	2	GO:0060077
GeneOntologyCellularComponent	site of polarized growth	FKBP15 FRYL PTPRF TENM2	2.29e-03	253	46	4	GO:0030427
GeneOntologyCellularComponent	axon	PYGB FKBP15 GRIK4 PTPRF TENM2 DYNC1H1 SPTAN1	3.13e-03	891	46	7	GO:0030424
Domain	NLGN4	NLGN4X NLGN4Y	5.42e-06	2	44	2	IPR030025
Domain	Tox-GHH_dom	TENM1 TENM2	3.24e-05	4	44	2	IPR028916
Domain	Ten_N	TENM1 TENM2	3.24e-05	4	44	2	IPR009471
Domain	Ten_N	TENM1 TENM2	3.24e-05	4	44	2	PF06484
Domain	TENEURIN_N	TENM1 TENM2	3.24e-05	4	44	2	PS51361
Domain	Tox-GHH	TENM1 TENM2	3.24e-05	4	44	2	PF15636
Domain	Nlgn	NLGN4X NLGN4Y	5.40e-05	5	44	2	IPR000460
Domain	YD	TENM1 TENM2	5.40e-05	5	44	2	IPR006530
Domain	CRAL_TRIO_N	CLVS1 CLVS2	2.94e-04	11	44	2	PF03765
Domain	CRAL-bd_toc_tran	CLVS1 CLVS2	3.53e-04	12	44	2	IPR001071
Domain	CRAL_TRIO_N	CLVS1 CLVS2	3.53e-04	12	44	2	SM01100
Domain	NHL	TENM1 TENM2	4.16e-04	13	44	2	PS51125
Domain	Carboxylesterase_B_CS	NLGN4X NLGN4Y	4.16e-04	13	44	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN4X NLGN4Y	4.85e-04	14	44	2	PS00941
Domain	COesterase	NLGN4X NLGN4Y	4.85e-04	14	44	2	PF00135
Domain	CarbesteraseB	NLGN4X NLGN4Y	4.85e-04	14	44	2	IPR002018
Domain	CRAL/TRIO_N_dom	CLVS1 CLVS2	5.59e-04	15	44	2	IPR011074
Domain	-	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	9.66e-04	679	44	7	3.30.160.60
Domain	zf-C2H2	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	1.09e-03	693	44	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	1.10e-03	694	44	7	IPR013087
Domain	CRAL_TRIO	CLVS1 CLVS2	1.11e-03	21	44	2	PF00650
Domain	-	CLVS1 CLVS2	1.33e-03	23	44	2	3.40.525.10
Domain	SEC14	CLVS1 CLVS2	1.57e-03	25	44	2	SM00516
Domain	CRAL_TRIO	CLVS1 CLVS2	1.83e-03	27	44	2	PS50191
Domain	CRAL-TRIO_dom	CLVS1 CLVS2	1.97e-03	28	44	2	IPR001251
Domain	ZINC_FINGER_C2H2_2	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	2.07e-03	775	44	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	2.10e-03	777	44	7	PS00028
Domain	Znf_C2H2-like	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	2.40e-03	796	44	7	IPR015880
Domain	Arm	PKP4 ANKAR	2.42e-03	31	44	2	PF00514
Domain	Znf_C2H2	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	2.56e-03	805	44	7	IPR007087
Domain	ZnF_C2H2	ZNF233 DZIP1 ZFHX4 ZNF273 ZNF730 ZFP37 PRDM1	2.62e-03	808	44	7	SM00355
Domain	-	TENM1 TENM2	3.80e-03	39	44	2	2.120.10.30
Domain	ARM_REPEAT	PKP4 ANKAR	4.00e-03	40	44	2	PS50176
Domain	ARM	PKP4 ANKAR	4.00e-03	40	44	2	SM00185
Domain	6-blade_b-propeller_TolB-like	TENM1 TENM2	5.26e-03	46	44	2	IPR011042
Domain	Armadillo	PKP4 ANKAR	5.48e-03	47	44	2	IPR000225
Domain	zf-C2H2_6	ZNF273 ZNF730 ZFP37 PRDM1	6.27e-03	314	44	4	PF13912
Domain	KRAB	ZNF233 ZNF273 ZNF730 ZFP37	9.86e-03	358	44	4	PS50805
Domain	KRAB	ZNF233 ZNF273 ZNF730 ZFP37	9.86e-03	358	44	4	PF01352
Domain	KRAB	ZNF233 ZNF273 ZNF730 ZFP37	1.09e-02	369	44	4	SM00349
Domain	KRAB	ZNF233 ZNF273 ZNF730 ZFP37	1.10e-02	370	44	4	IPR001909
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4X NLGN4Y	1.71e-06	2	46	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4X NLGN4Y	1.71e-06	2	46	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4X NLGN4Y	1.71e-06	2	46	2	24104404
Pubmed	Undifferentiated Round Cell Sarcoma With CRTC1::SS18 Fusion: Expanding Clinicopathologic Features of a Rare Translocation Sarcoma With Prominent Desmoplastic Stroma.	CRTC1 SS18	1.71e-06	2	46	2	38972355
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4X NLGN4Y	1.71e-06	2	46	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4X NLGN4Y	1.71e-06	2	46	2	22989184
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4X NLGN4Y	1.71e-06	2	46	2	18434543
Pubmed	The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.	CLVS1 CLVS2	1.71e-06	2	46	2	19651769
Pubmed	Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion.	CRTC1 SS18	1.71e-06	2	46	2	29533464
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4X NLGN4Y	1.71e-06	2	46	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4X NLGN4Y	1.71e-06	2	46	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4X NLGN4Y	1.71e-06	2	46	2	37001827
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4X NLGN4Y	1.71e-06	2	46	2	37080762
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PPP3CB NLGN4X NLGN4Y DYNC1H1 SPTAN1 PKP4	1.88e-06	281	46	6	28706196
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4X NLGN4Y	5.13e-06	3	46	2	18628683
Pubmed	Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1.	NLRP12 PRDM1	5.13e-06	3	46	2	19234190
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4X NLGN4Y	5.13e-06	3	46	2	32011705
Pubmed	Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1.	NLRP12 PRDM1	5.13e-06	3	46	2	27105524
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN4Y	5.13e-06	3	46	2	21282647
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM1 TENM2	1.03e-05	4	46	2	10225957
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4X NLGN4Y	1.03e-05	4	46	2	16077734
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4X NLGN4Y	1.03e-05	4	46	2	17292328
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN4Y	1.03e-05	4	46	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN4Y	1.03e-05	4	46	2	22671294
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4X NLGN4Y	1.03e-05	4	46	2	20579107
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM1 TENM2	1.03e-05	4	46	2	12000766
Pubmed	PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.	CRTC1 PDK4	1.03e-05	4	46	2	25164809
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4X NLGN4Y	1.71e-05	5	46	2	18923512
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN4Y	1.71e-05	5	46	2	10996085
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN4Y	1.71e-05	5	46	2	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4X NLGN4Y	2.56e-05	6	46	2	21838267
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4X NLGN4Y	2.56e-05	6	46	2	29724786
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM1 TENM2	3.58e-05	7	46	2	12915301
Pubmed	Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.	TENM1 TENM2 DYNC1H1	4.31e-05	51	46	3	16919471
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM1 TENM2	4.77e-05	8	46	2	10331952
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4X NLGN4Y	4.77e-05	8	46	2	30871858
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NLGN4X NLGN4Y	6.12e-05	9	46	2	23010509
Pubmed	Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development.	ID1 PRDM1	6.12e-05	9	46	2	34584102
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	NLGN4X NLGN4Y	6.12e-05	9	46	2	29252214
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	PYGB PPP3CB DYNC1H1 SPTAN1	6.51e-05	163	46	4	16512683
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM1 TENM2	7.65e-05	10	46	2	38713721
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4X NLGN4Y	9.34e-05	11	46	2	32973045
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4X NLGN4Y	9.34e-05	11	46	2	26403076
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	NLRP12 VPS13D ZNF273	9.78e-05	67	46	3	34644545
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8C NLRP12	1.12e-04	12	46	2	32277911
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	NLGN4X NLGN4Y	1.32e-04	13	46	2	27050589
Pubmed	Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract.	CLVS1 CLVS2	1.32e-04	13	46	2	31219639
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4X NLGN4Y	1.78e-04	15	46	2	18227507
Pubmed	Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.	TENM1 ATP10A TENM2	2.42e-04	91	46	3	22610502
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 MYO5C	5.04e-04	25	46	2	30309841
Pubmed	Global gene expression analysis of murine limb development.	ID1 ZFHX4 PRDM1	5.07e-04	117	46	3	22174793
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NLGN4X NLGN4Y	5.45e-04	26	46	2	34848499
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	FRYL DYNC1H1 SPTAN1	5.46e-04	120	46	3	31413325
Pubmed	Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis.	ID1 PRDM1	6.79e-04	29	46	2	30048641
Pubmed	Role of Elavl-like RNA-binding protein in retinal development and signal transduction.	NLGN4X NLGN4Y	7.77e-04	31	46	2	39307290
Pubmed	Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.	ID1 PRDM1	7.77e-04	31	46	2	23469192
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	FRYL ZFHX4 SPTAN1	8.89e-04	142	46	3	11812828
Pubmed	The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.	SS18 PRDM1	9.35e-04	34	46	2	20007774
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	PPP3CB DYNC1H1 SPTAN1	9.83e-04	147	46	3	16959763
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	FRYL DYNC1H1 SPTAN1	1.06e-03	151	46	3	17043677
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	DZIP1 PPP3CB	1.23e-03	39	46	2	22802532
Pubmed	Protein-protein interaction panel using mouse full-length cDNAs.	ID1 FRYL SS18	1.28e-03	161	46	3	11591653
Cytoband	6q22.31	CLVS2 MCM9	3.39e-04	27	46	2	6q22.31
Cytoband	1p36.22	VPS13D SLC25A33	6.40e-04	37	46	2	1p36.22
Cytoband	9q32	FKBP15 ZFP37	1.03e-03	47	46	2	9q32
Cytoband	Ensembl 112 genes in cytogenetic band chr9q32	FKBP15 ZFP37	1.17e-03	50	46	2	chr9q32
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PKP4 ANKAR	2.46e-03	43	31	2	409
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF233 ZNF273 ZNF730 ZFP37 PRDM1	7.02e-03	718	31	5	28
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PYGB DZIP1 NLGN4X GALNT7 PKP4 MYO5C	3.53e-08	184	46	6	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DZIP1 NLGN4X GALNT7 PDK4 PKP4	1.30e-06	184	46	5	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ID1 FRYL PTPRF GALNT7 MYO5C	1.68e-06	194	46	5	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ID1 FRYL PTPRF GALNT7 MYO5C	1.68e-06	194	46	5	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ID1 FRYL PTPRF GALNT7 MYO5C	1.77e-06	196	46	5	c2d17630f7bfc9e727de55e093c17fddac61b61f
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	PYGB DZIP1 NLGN4Y PKP4 MYO5C	1.77e-06	196	46	5	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ID1 FRYL PTPRF GALNT7 MYO5C	1.77e-06	196	46	5	54c30023d04e7265373647f56fc93885804938b0
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ID1 LRRC8C HDX PRDM1	3.11e-05	174	46	4	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TENM2 IQGAP3 PKP4 ANXA10	3.18e-05	175	46	4	9142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	VPS13D GRIK4 DYNC1H1 SPTAN1	3.32e-05	177	46	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DZIP1 NLGN4X GALNT7 PKP4	3.62e-05	181	46	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ID1 DZIP1 NLGN4X ZFHX4	4.20e-05	188	46	4	116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DZIP1 NLGN4X PDK4 PKP4	4.29e-05	189	46	4	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ID1 PTPRF PKP4 MYO5C	5.04e-05	197	46	4	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ID1 PTPRF PKP4 MYO5C	5.04e-05	197	46	4	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium\|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X	ID1 NLGN4X PTPRF ZFHX4	5.24e-05	199	46	4	6cfefd81e8a1a883fb4279ac4ab0b298ed2a0817
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ID1 LRRC8C SPTAN1 PKP4	5.34e-05	200	46	4	b3f93b71589251197cde96b7bc6d065c106f61cd
Drug	Ginkgolide A [15291-75-5]; Up 200; 9.8uM; HL60; HT_HG-U133A	PYGB CRTC1 ZFYVE9 ZFHX4 SS18 PRDM1	2.39e-06	197	45	6	1324_UP
Drug	Benzocaine [94-09-7]; Up 200; 24.2uM; HL60; HT_HG-U133A	PYGB VPS13D SS18 PDK4 ZFP37 PRDM1	2.61e-06	200	45	6	2167_UP
Drug	Sulfamonomethoxine [1220-83-3]; Down 200; 14.2uM; HL60; HT_HG-U133A	CRTC1 VPS13D ZFHX4 PKP4 PRDM1	3.95e-05	194	45	5	2742_DN
Drug	Napelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	CRTC1 ZFHX4 ATP10A PDK4 PRDM1	4.15e-05	196	45	5	6824_UP
Drug	Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; HL60; HT_HG-U133A	PYGB FKBP15 ZFYVE9 PTPRF SS18	4.15e-05	196	45	5	2451_UP
Drug	Nizatidine [76963-41-2]; Up 200; 12uM; PC3; HT_HG-U133A	CRTC1 VPS13D SAMD9 PKP4 ANXA10	4.15e-05	196	45	5	6305_UP
Drug	CGX 0596987; Up 200; 20uM; MCF7; HT_HG-U133A	NLGN4X ZFHX4 ATP10A PDK4 PRDM1	4.15e-05	196	45	5	6364_UP
Drug	Pizotifen malate [5189-11-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	CRTC1 VPS13D DZIP1 SPTAN1 ANXA10	4.15e-05	196	45	5	5072_DN
Drug	Niflumic acid [4394-00-7]; Up 200; 14.2uM; HL60; HT_HG-U133A	CRTC1 ZFYVE9 SS18 PKP4 PRDM1	4.46e-05	199	45	5	2399_UP
Disease	Drug habituation	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0013170
Disease	Substance-Related Disorders	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0236969
Disease	Drug abuse	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0013146
Disease	Drug Use Disorders	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0013222
Disease	Drug Dependence	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C1510472
Disease	Substance Dependence	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0038580
Disease	Substance Use Disorders	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C0029231
Disease	Prescription Drug Abuse	FKBP15 TENM2 MYO5C	6.80e-04	115	44	3	C4316881
Disease	Substance abuse problem	FKBP15 TENM2 MYO5C	6.97e-04	116	44	3	C0740858
Disease	response to vaccine, cytokine measurement	TENM1 ATP10A TENM2	9.91e-04	131	44	3	EFO_0004645, EFO_0004873

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYRVQECNYNRLQHA	PKP4	486	Q99569
QMREAYCLQYSNNLQ	ANXA10	126	Q9UJ72
ACQVYFINQDMQLYD	ATP10A	386	O60312
TNQNLQYFLDRFYMN	PDK4	151	Q16654
NQDYLDICTYQRLQQ	ANKAR	276	Q7Z5J8
QVNVLLYDMNGCYSR	ID1	61	P41134
QRYYENGMTNQSKNC	HDX	16	Q7Z353
QNQIRNCYQNFLDYH	COX6B2	26	Q6YFQ2
SYNRACELAQMVQLY	DSG4	571	Q86SJ6
FQNRDYQCDTVMLLN	FRYL	1196	O94915
LQQYQEVCAQRDAYQ	FKBP15	821	Q5T1M5
MDEQRRQNVAYQYLC	IQGAP3	21	Q86VI3
MTYVQDQNEDCLYLN	NLGN4Y	136	Q8NFZ3
FRNHTACMEEQYNQY	EEF1AKMT4-ECE2	751	P0DPD8
AYDNVYQQLQHCLLM	CCDC63	191	Q8NA47
DAYYEQQMAARQANA	CRTC1	486	Q6UUV9
FRINEANQLMQYDQC	GALNT7	571	Q86SF2
QYQCLWDMQAENIYN	DYNC1H1	1056	Q14204
MNEYYRQRNCNLTQI	GRIK4	726	Q16099
LKYENNVMNIRQFNC	PPP3CB	331	P16298
MTYVQDQNEDCLYLN	NLGN4X	136	Q8N0W4
MVQTEDQYQLCYRAA	PTPRF	1881	P10586
LNYMYNAALEINNAN	KBTBD12	86	Q3ZCT8
LLRYYQMQRQSDCRN	MCM9	546	Q9NXL9
CQYDYFQIKMQNYNN	SAMD9	316	Q5K651
LHEYNQELRMNYNSQ	TENM1	46	Q9UKZ4
NSYQLCNNGTLRVMY	TENM2	1766	Q9NT68
QNLAACQNGMNIYFY	PRDM1	171	O75626
SYQLQAQMNRAVYED	WDR13	116	Q9H1Z4
TQQLMIEAKANYYQC	DZIP1	186	Q86YF9
KQMNTLQCARYVYQT	SLC25A33	166	Q9BSK2
QYFQYRQLNLDMFKN	CLVS1	96	Q8IUQ0
LLAQYFEYRQQNLDM	CLVS2	71	Q5SYC1
TSQQNLYRNVMLDNY	ZNF273	56	Q14593
YCNYNSRDQSRIQMH	ZFHX4	1176	Q86UP3
NERYIRTSNMQYQCK	ZFHX4	2256	Q86UP3
ECSQYQQMLHTNLVY	SS18	46	Q15532
QQYEQCMDLQLFYRD	SPTAN1	461	Q13813
YMQCQAQVDQLYRNP	PYGB	781	P11216
QNLYRNVMLDNYRNL	ZNF730	26	Q6ZMV8
MYLREPQNYQSRCQQ	ZNF233	186	A6NK53
NRETELYQYNILQMN	TTC37	946	Q6PGP7
LYNDVMLENYCNQAS	ZFP37	56	Q9Y6Q3
LQDCNNYNSQSLMDA	ZFYVE9	166	O95405
CNMNDFQDNRQLYYE	VPS13D	3576	Q5THJ4
QQYSFINQMCYERAL	LRRC8C	106	Q8TDW0
NMNIFQKDINCERYY	NLRP12	496	P59046
VLQQLSYFYTTMCQN	MYO5C	1551	Q9NQX4