Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	clearance of foreign intracellular DNA	APOBEC3D APOBEC3B	8.24e-05	6	49	2	GO:0044355
GeneOntologyBiologicalProcess	clearance of foreign intracellular nucleic acids	APOBEC3D APOBEC3B	8.24e-05	6	49	2	GO:0099046
GeneOntologyBiologicalProcess	renal system vasculature morphogenesis	NOTCH2 NRP1	1.15e-04	7	49	2	GO:0061438
GeneOntologyBiologicalProcess	kidney vasculature morphogenesis	NOTCH2 NRP1	1.15e-04	7	49	2	GO:0061439
Domain	ZF_PHD_1	KMT2C PHF20L1 PHF14 KMT2E	1.07e-04	96	48	4	PS01359
Domain	Notch_dom	PAPPA2 NOTCH2	1.35e-04	7	48	2	IPR000800
Domain	Notch	PAPPA2 NOTCH2	1.35e-04	7	48	2	PF00066
Domain	NL	PAPPA2 NOTCH2	1.35e-04	7	48	2	SM00004
Domain	APOBEC_N	APOBEC3D APOBEC3B	4.20e-04	12	48	2	PF08210
Domain	APOBEC_N	APOBEC3D APOBEC3B	4.20e-04	12	48	2	IPR013158
Domain	WD40	WDR37 EML3 HIRA FBXW11 WDR48	5.19e-04	259	48	5	PF00400
Domain	Znf_FYVE_PHD	KMT2C PHF20L1 PHF14 KMT2E	5.48e-04	147	48	4	IPR011011
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3B	5.77e-04	14	48	2	IPR016192
Domain	WD40	WDR37 EML3 HIRA FBXW11 WDR48	6.06e-04	268	48	5	SM00320
Domain	Cadherin_2	PCDH10 PCDH8 PCDH9	6.22e-04	65	48	3	PF08266
Domain	Zinc_finger_PHD-type_CS	PHF20L1 PHF14 KMT2E	6.22e-04	65	48	3	IPR019786
Domain	Cadherin_N	PCDH10 PCDH8 PCDH9	6.22e-04	65	48	3	IPR013164
Domain	WD40_repeat	WDR37 EML3 HIRA FBXW11 WDR48	6.48e-04	272	48	5	IPR001680
Domain	WD_REPEATS_1	WDR37 EML3 HIRA FBXW11 WDR48	7.15e-04	278	48	5	PS00678
Domain	WD_REPEATS_2	WDR37 EML3 HIRA FBXW11 WDR48	7.27e-04	279	48	5	PS50082
Domain	WD_REPEATS_REGION	WDR37 EML3 HIRA FBXW11 WDR48	7.27e-04	279	48	5	PS50294
Domain	WD40_repeat_CS	WDR37 HIRA FBXW11 WDR48	8.25e-04	164	48	4	IPR019775
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3B	8.58e-04	17	48	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3B	8.58e-04	17	48	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3B	8.58e-04	17	48	2	IPR002125
Domain	PHD	KMT2C PHF14 KMT2E	9.45e-04	75	48	3	PF00628
Domain	WD40_repeat_dom	WDR37 EML3 HIRA FBXW11 WDR48	9.62e-04	297	48	5	IPR017986
Domain	Znf_PHD-finger	KMT2C PHF14 KMT2E	1.10e-03	79	48	3	IPR019787
Domain	MetalloPept_cat_dom	PAPPA2 ADAMTS7 ADAM20	1.18e-03	81	48	3	IPR024079
Domain	-	PAPPA2 ADAMTS7 ADAM20	1.18e-03	81	48	3	3.40.390.10
Domain	G-protein_beta_WD-40_rep	WDR37 FBXW11 WDR48	1.36e-03	85	48	3	IPR020472
Domain	EPHD	KMT2C PHF14	1.45e-03	22	48	2	PS51805
Domain	PHD	KMT2C PHF14 KMT2E	1.55e-03	89	48	3	SM00249
Domain	-	WDR37 EML3 HIRA FBXW11 WDR48	1.60e-03	333	48	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR37 EML3 HIRA FBXW11 WDR48	1.64e-03	335	48	5	IPR015943
Domain	Znf_PHD	KMT2C PHF14 KMT2E	1.65e-03	91	48	3	IPR001965
Domain	ZF_PHD_2	KMT2C PHF14 KMT2E	1.87e-03	95	48	3	PS50016
Domain	ZINC_PROTEASE	PAPPA2 ADAMTS7 ADAM20	2.04e-03	98	48	3	PS00142
Domain	Cadherin_CS	PCDH10 PCDH8 PCDH9	2.76e-03	109	48	3	IPR020894
Domain	CADHERIN_1	PCDH10 PCDH8 PCDH9	3.06e-03	113	48	3	PS00232
Domain	Cadherin	PCDH10 PCDH8 PCDH9	3.06e-03	113	48	3	PF00028
Domain	CADHERIN_2	PCDH10 PCDH8 PCDH9	3.14e-03	114	48	3	PS50268
Domain	-	PCDH10 PCDH8 PCDH9	3.14e-03	114	48	3	2.60.40.60
Domain	CA	PCDH10 PCDH8 PCDH9	3.21e-03	115	48	3	SM00112
Domain	Cadherin-like	PCDH10 PCDH8 PCDH9	3.29e-03	116	48	3	IPR015919
Domain	Cadherin	PCDH10 PCDH8 PCDH9	3.46e-03	118	48	3	IPR002126
Domain	Peptidase_M12B_N	ADAMTS7 ADAM20	4.51e-03	39	48	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS7 ADAM20	4.51e-03	39	48	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS7 ADAM20	4.74e-03	40	48	2	PS00427
Domain	Reprolysin	ADAMTS7 ADAM20	4.74e-03	40	48	2	PF01421
Domain	ADAM_MEPRO	ADAMTS7 ADAM20	4.74e-03	40	48	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS7 ADAM20	4.74e-03	40	48	2	PS50214
Domain	Peptidase_M12B	ADAMTS7 ADAM20	4.74e-03	40	48	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS7 ADAM20	4.98e-03	41	48	2	PS00546
Domain	SET	KMT2C KMT2E	4.98e-03	41	48	2	PF00856
Domain	Disintegrin_dom	ADAMTS7 ADAM20	4.98e-03	41	48	2	IPR001762
Pathway	REACTOME_MRNA_EDITING_C_TO_U_CONVERSION	APOBEC3D APOBEC3B	1.11e-04	7	33	2	MM15412
Pathway	REACTOME_MRNA_EDITING	APOBEC3D APOBEC3B	1.89e-04	9	33	2	MM15445
Pubmed	Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	32641479
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	27602762
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	286744
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	22691411
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	22666481
Pubmed	APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	24577894
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	24725948
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	16648136
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	23533681
Pubmed	The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	20702647
Pubmed	Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	1541833
Pubmed	In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	27356895
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	23315078
Pubmed	Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	20980520
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	25589647
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	284359
Pubmed	Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	20617165
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	31801862
Pubmed	Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	39208378
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	31943071
Pubmed	Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	23671100
Pubmed	Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	31518043
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	20566830
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	31595054
Pubmed	APOBEC3 signature mutations in chronic lymphocytic leukemia.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	24840555
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	17967065
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	20335265
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	29593034
Pubmed	Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	31830125
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	9765497
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	21998583
Pubmed	Biochemical and biological studies of mouse APOBEC3.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	24453360
Pubmed	Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	38115583
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	23449789
Pubmed	USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.	MAP3K7 WDR48	6.07e-06	3	50	2	33461373
Pubmed	Effects of zidovudine on Friend virus complex infection in Rfv-3r/s genotype-containing mice used as a model for HIV infection.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	2157836
Pubmed	Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	35458563
Pubmed	Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	22275865
Pubmed	APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	18434399
Pubmed	Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	19153238
Pubmed	Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	18772436
Pubmed	Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	293683
Pubmed	Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	19150103
Pubmed	Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	18786991
Pubmed	Initial sequencing and comparative analysis of the mouse genome.	APOBEC3D APOBEC3B	6.07e-06	3	50	2	12466850
Pubmed	Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	24821801
Pubmed	Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	20363737
Pubmed	Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	18983852
Pubmed	Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	29343743
Pubmed	APOBEC3 regulates keratinocyte differentiation and expression of Notch3.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	31400166
Pubmed	APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	15674295
Pubmed	Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	21873525
Pubmed	Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	23725696
Pubmed	APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	21985787
Pubmed	APOBEC3A functions as a restriction factor of human papillomavirus.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	25355878
Pubmed	Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	26253512
Pubmed	APOBEC3 enzymes restrict marginal zone B cells.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	25501566
Pubmed	Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	18702815
Pubmed	HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	20538015
Pubmed	Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	17020885
Pubmed	Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	20375169
Pubmed	APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	21147467
Pubmed	Mice deficient in APOBEC2 and APOBEC3.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	16055735
Pubmed	The incorporation of APOBEC3 proteins into murine leukemia viruses.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	18572219
Pubmed	The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	38049664
Pubmed	Restriction of foamy viruses by APOBEC cytidine deaminases.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	16378963
Pubmed	Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	26846717
Pubmed	Vaccinia virus replication is not affected by APOBEC3 family members.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	17052331
Pubmed	Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	28415995
Pubmed	Immunity to retroviral infection: the Friend virus model.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	9223268
Pubmed	Species-specific restriction of apobec3-mediated hypermutation.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	18032489
Pubmed	Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	32893454
Pubmed	Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	25303118
Pubmed	APOBEC3 inhibits mouse mammary tumour virus replication in vivo.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	17259974
Pubmed	HIV restriction by APOBEC3 in humanized mice.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	23555255
Pubmed	The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	36480186
Pubmed	Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14.	PCDH8 PCDH9	1.21e-05	4	50	2	9787079
Pubmed	Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.	APOBEC3D APOBEC3B	1.21e-05	4	50	2	15269786
Pubmed	Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.	PCDH10 PCDH8 PCDH9	1.77e-05	35	50	3	25977363
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF438 ZNF131 PHF20L1 PHF14 HBP1 ZNF318 EXOC2 ZNF786	1.86e-05	808	50	8	20412781
Pubmed	APOBEC3 inhibits DEAD-END function to regulate microRNA activity.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	23890083
Pubmed	Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	21659520
Pubmed	HIV-1 Vif, APOBEC, and intrinsic immunity.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	18577210
Pubmed	Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	24851906
Pubmed	IFN-α and lipopolysaccharide upregulate APOBEC3 mRNA through different signaling pathways.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	22972924
Pubmed	The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.	APOBEC3D APOBEC3B	2.02e-05	5	50	2	18304004
Pubmed	Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).	APOBEC3D APOBEC3B	2.02e-05	5	50	2	18509452
Pubmed	SERINC5 Potently Restricts Retrovirus Infection In Vivo.	APOBEC3D APOBEC3B	3.03e-05	6	50	2	32665269
Pubmed	Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.	APOBEC3D APOBEC3B	3.03e-05	6	50	2	22912627
Pubmed	Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.	MAP3K7 NOTCH2	3.03e-05	6	50	2	29228365
Pubmed	APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.	APOBEC3D APOBEC3B	3.03e-05	6	50	2	22720156
Pubmed	APOBEC3 proteins mediate the clearance of foreign DNA from human cells.	APOBEC3D APOBEC3B	4.23e-05	7	50	2	20062055
Pubmed	An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.	APOBEC3D APOBEC3B	4.23e-05	7	50	2	11863358
Pubmed	APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.	APOBEC3D APOBEC3B	4.23e-05	7	50	2	16527742
Pubmed	DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection.	APOBEC3D APOBEC3B	4.23e-05	7	50	2	29871919
Pubmed	Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.	APOBEC3D APOBEC3B	4.23e-05	7	50	2	21835787
Pubmed	Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.	LRP10 PCDH8 PCDH9	4.92e-05	49	50	3	21795542
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2E	5.64e-05	8	50	2	23130995
Interaction	UMODL1 interactions	ZNF318 MAP3K7 NOTCH2	7.87e-06	16	50	3	int:UMODL1
GeneFamily	Non-clustered protocadherins	PCDH10 PCDH8 PCDH9	1.71e-06	12	37	3	21
GeneFamily	PHD finger proteins	KMT2C PHF20L1 PHF14 KMT2E	3.34e-05	90	37	4	88
GeneFamily	WD repeat domain containing	WDR37 EML3 HIRA FBXW11 WDR48	1.83e-04	262	37	5	362
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	2.66e-04	12	37	2	406
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2E	2.19e-03	34	37	2	487
Coexpression	GSE40068_BCL6_POS_VS_NEG_CXCR5_POS_TFH_DN	KMT2C IQSEC1 PHF14 HBP1 KMT2E CLIP1	2.20e-06	200	50	6	M9260
Coexpression	GSE37416_0H_VS_48H_F_TULARENSIS_LVS_NEUTROPHIL_UP	PHF20L1 LRP10 EML3 NOTCH2 HIRA	3.67e-05	197	50	5	M5351
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	KMT2C PHF20L1 KMT2E CTSW HIRA	3.94e-05	200	50	5	M9439
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1B PCDH10 PCDH9 DIRAS3 KHDC1	2.76e-06	197	50	5	3a0e97bfebe82f9687d518baaad7f20d0ffea8a1
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; HL60; HG-U133A	ZNF131 MAP3K7 CLIP1 NOTCH2 HIRA WDR48	4.37e-06	196	50	6	1987_DN
Drug	GSK-3 Inhibitor IX; Down 200; 0.5uM; MCF7; HT_HG-U133A	HBP1 RB1CC1 MAP3K7 NOTCH2 FBXW11 WDR48	4.50e-06	197	50	6	7101_DN
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ZNF318 MAP3K7 CLIP1 FBXW11 WDR48	6.00e-05	190	50	5	7439_DN
Drug	Fluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; HL60; HG-U133A	DNAJC10 IQSEC1 HBP1 ZNF318 WDR48	6.46e-05	193	50	5	1577_UP
Drug	Canrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; MCF7; HT_HG-U133A	CLIP1 PCDH9 EML3 NOTCH2 HIRA	6.46e-05	193	50	5	6783_DN
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ZNF318 PCDH9 NOTCH2 HIRA WDR48	6.62e-05	194	50	5	7214_DN
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	TRAPPC13 HBP1 RB1CC1 NRP1 WDR48	6.62e-05	194	50	5	1001_UP
Drug	Seneciphylline [480-81-9]; Down 200; 12uM; MCF7; HT_HG-U133A	TRAPPC13 DNAJC10 NOTCH2 HIRA NRP1	6.62e-05	194	50	5	4822_DN
Drug	Pyrilamine maleate [59-33-6]; Down 200; 10uM; MCF7; HT_HG-U133A	ZNF318 NOTCH2 HIRA FBXW11 WDR48	6.62e-05	194	50	5	3184_DN
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; PC3; HG-U133A	ZNF318 MAP3K7 CLIP1 NOTCH2 WDR48	6.78e-05	195	50	5	1960_UP
Drug	Cisapride [81098-60-4]; Down 200; 8.6uM; PC3; HT_HG-U133A	MAP3K7 CLIP1 NOTCH2 FBXW11 NRP1	6.78e-05	195	50	5	6706_DN
Drug	Norethynodrel [68-23-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A	IQSEC1 ZNF318 APOBEC3B EML3 HIRA	6.95e-05	196	50	5	1696_DN
Drug	Mafenide hydrochloride [138-37-4]; Up 200; 18uM; HL60; HG-U133A	ZNF318 RB1CC1 NOTCH2 HIRA NRP1	7.12e-05	197	50	5	1441_UP
Drug	Azathioprine [446-86-6]; Up 200; 14.4uM; HL60; HG-U133A	PAPPA2 ACADVL EML3 FBXW11 WDR48	7.47e-05	199	50	5	2028_UP
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; HL60; HG-U133A	DNAJC10 PHF20L1 EML3 HIRA WDR48	7.47e-05	199	50	5	1738_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; HL60; HG-U133A	DNAJC10 PHF20L1 ACADVL MAP3K7 CLIP1	7.47e-05	199	50	5	1588_DN
Drug	Mephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; PC3; HT_HG-U133A	PAPPA2 TRAPPC13 EML3 NOTCH2 NRP1	7.47e-05	199	50	5	7384_UP
Disease	Global developmental delay	CACNA1B IQSEC1 KMT2E WDR37 FBXW11	2.27e-06	133	47	5	C0557874
Disease	Abnormality of the eye	WDR37 FBXW11	5.19e-05	7	47	2	C4316870
Disease	AUTISM, SUSCEPTIBILITY TO, 15	WDR37 FBXW11	6.91e-05	8	47	2	C2677504
Disease	Intellectual Disability	CACNA1B KMT2C IQSEC1 KMT2E WDR37 FBXW11	7.42e-05	447	47	6	C3714756
Disease	migraine disorder, endometriosis	ZNF438 EXOC2 NRP1	2.18e-04	73	47	3	EFO_0001065, MONDO_0005277
Disease	cortical thickness	ZNF438 PHYH ADAMTS7 FSD2 ZNF318 EXOC2 MAP3K7 NRP1	3.39e-04	1113	47	8	EFO_0004840
Disease	descending aortic diameter	PAPPA2 ADAMTS7 PI15	3.78e-04	88	47	3	EFO_0021788
Disease	cervical cancer	APOBEC3B NOTCH2	1.35e-03	34	47	2	C4048328
Disease	Uterine Cervical Neoplasm	APOBEC3B NOTCH2	1.43e-03	35	47	2	C0007873
Disease	Bladder Neoplasm	KMT2C APOBEC3B NOTCH2	1.45e-03	140	47	3	C0005695
Disease	Malignant neoplasm of breast	ZNF438 ZNF318 RB1CC1 CLIP1 PCDH8 APOBEC3B NOTCH2	1.46e-03	1074	47	7	C0006142
Disease	Malignant neoplasm of urinary bladder	KMT2C APOBEC3B NOTCH2	1.48e-03	141	47	3	C0005684
Disease	lung adenocarcinoma (is_implicated_in)	KMT2C IQSEC1	2.78e-03	49	47	2	DOID:3910 (is_implicated_in)
Disease	Prostatic Neoplasms	KMT2C DNAJC10 MAP3K7 PCDH8 NRP1	2.90e-03	616	47	5	C0033578
Disease	Malignant neoplasm of prostate	KMT2C DNAJC10 MAP3K7 PCDH8 NRP1	2.90e-03	616	47	5	C0376358
Disease	dental caries	PHF14 EXOC2 PCDH9	3.31e-03	187	47	3	EFO_0003819
Disease	Diffuse Large B-Cell Lymphoma	BCAS2 NOTCH2	3.49e-03	55	47	2	C0079744

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENHAEMCFLSWFCGN	APOBEC3D	76	Q96AK3
HAEMCFLSWFCGNQL	APOBEC3B	66	Q9UH17
HNLGMQHDTQWCVCE	ADAM20	346	O43506
DHGMELICCFGNTSW	BCDIN3D	241	Q7Z5W3
DDLNCTGMESHLWQC	CD163L1	1101	Q9NR16
ENDGSDIWMTSEHCI	CC2D2B	1161	Q6DHV5
AWHEIMLSCLSNQAC	CACNA1B	1656	Q00975
EDMDNVCHTLWCSVG	ADAMTS7	486	Q9UKP4
QHQGWAAIMANLEDC	RB1CC1	146	Q8TDY2
HACQWDGGDCSLTME	NOTCH2	1446	Q04721
MFSDNSHCPDCGQQW	TOR1AIP2	1	Q9H496
DLCMTLDLQWLCHGN	KIAA0100	1206	Q14667
CDRWMHAVCQNLNTE	KMT2C	1106	Q8NEZ4
DWLMCLQEEFQCLNH	LRP10	136	Q7Z4F1
MWCLHCNSERTQSLL	IQSEC1	1	Q6DN90
MHDQDVDSCEKWLNC	ISM2	396	Q6H9L7
LTICGHNCLLTAEWM	EXOC2	41	Q96KP1
INHMQSGLWACTAEC	PCDH8	941	O95206
QECLVLGHSDNCWMP	PCDH9	1131	Q9HC56
SLWLGCANLVESMCA	FBXW11	21	Q9UKB1
TAAHAMSWCLQCSQG	MAP3K7	126	O43318
DKCSVWQHIDCMGID	KMT2E	136	Q8IZD2
TEECKALGHSDRCWM	PCDH10	941	Q9P2E7
WQCSECDQAGSSDME	PHF14	771	O94880
CACWHNGMSERNLSA	NRP1	881	O14786
WNRRDGLCHVECNNM	PAPPA2	621	Q9BXP8
NCCWAMAAAGNIETL	CTSW	151	P56202
LHCMEADGWTDVNSA	ITIH6	351	Q6UXX5
RQWLLHMFCCVGSQD	KHDC1	151	Q4VXA5
CMSSLSDDDDLGWCN	HBP1	191	O60381
DSNEHMLSVWDCSRG	EML3	381	Q32P44
WMDCATQDNLCKSLD	DNAJC10	291	Q8IXB1
MDNHLACVNCVRWSN	HIRA	66	P54198
VALNDGATCAMEWNC	DIRAS3	161	O95661
ICEMFGHWATNCNDD	CLIP1	1421	P30622
CAWTAMEHISRNNGC	PHYH	191	O14832
CLCWQHSVCMGLLEE	PHF20L1	701	A8MW92
STDWLCNGELSHDCD	SAMD8	106	Q96LT4
QEDLGANCLSWCMRH	FSD2	646	A1L4K1
IENLELMSQHGCNAW	BCAS2	121	O75934
AQHEKMLCDTWCIEA	ACADVL	596	P49748
LSDWHTGLTDCCNDM	CNFN	21	Q9BYD5
MEHHTDWVNDIVLCC	WDR48	71	Q8TAF3
WDNCLSEDMAENICS	SPATA46	126	Q5T0L3
VCGESCWENNHLVMH	ZNF786	191	Q8N393
QGHRRMVCCSAWSED	WDR37	451	Q9Y2I8
HCTLCDLWFMQGNEL	ZNF131	421	P52739
CAIHTCQNMNVWGSV	PI15	186	O43692
LEMCNTNSIHWCGIS	TRAPPC13	341	A5PLN9
WSHSGFNCLLCAEML	ZNF438	771	Q7Z4V0
HWCKDCNTICGTMFD	ZNF318	1066	Q5VUA4