Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.90e-09111085GO:0008503
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.42e-08181085GO:0022851
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.62e-08191085GO:0004890
GeneOntologyMolecularFunctionGABA receptor activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.03e-07221085GO:0016917
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.36e-06501085GO:0099095
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GABRA1 GABRA2 GABRA3 GABRA5

7.91e-06241084GO:0099507
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.41e-05571085GO:1904315
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.82e-05601085GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.69e-05651085GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.69e-05651085GO:0022824
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.39e-05751085GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.11e-05771085GO:0005230
GeneOntologyMolecularFunctionchloride channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.04e-04861085GO:0005254
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.11e-041001085GO:0030594
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.42e-041031085GO:0005253
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ETV3 POU4F2 ZBTB26 PPARA NFATC2 ZNF43 ZBTB5 ZFHX3

3.50e-043201088GO:0001227
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN5A SCN9A

3.65e-04261083GO:0005248
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ETV3 POU4F2 ZBTB26 PPARA NFATC2 ZNF43 ZBTB5 ZFHX3

3.96e-043261088GO:0001217
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.91e-041251085GO:0015108
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.38e-031511085GO:0008509
GeneOntologyMolecularFunctionaxon guidance receptor activity

ROBO1 EPHB1

2.17e-03131082GO:0008046
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.38e-031711085GO:0015103
GeneOntologyMolecularFunctionaminoacyl-tRNA editing activity

TARS2 LARS2

2.53e-03141082GO:0002161
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN9A

2.53e-03141082GO:0031402
GeneOntologyMolecularFunctionsodium channel activity

SCN2A SCN5A SCN9A

2.80e-03521083GO:0005272
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHA4 EPHB1

2.91e-03151082GO:0005005
GeneOntologyBiologicalProcessinhibitory synapse assembly

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.04e-07301105GO:1904862
GeneOntologyBiologicalProcesssynapse organization

LGMN FRMPD4 RAPGEF4 ADGRB3 SRGAP3 ROBO1 SRGAP2B IGSF21 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

7.05e-0768511016GO:0050808
GeneOntologyBiologicalProcesssynapse assembly

ADGRB3 SRGAP3 ROBO1 SRGAP2B CAPRIN1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

7.91e-0730811011GO:0007416
GeneOntologyBiologicalProcessgamma-aminobutyric acid signaling pathway

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.12e-06351105GO:0007214
GeneOntologyBiologicalProcesscell junction organization

LGMN FRMPD4 RAPGEF4 ADGRB3 SRGAP3 ROBO1 MACF1 SRGAP2B IGSF21 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

1.54e-0597411017GO:0034330
GeneOntologyBiologicalProcesssynaptic transmission, GABAergic

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.73e-05741105GO:0051932
GeneOntologyBiologicalProcesscell junction assembly

ADGRB3 SRGAP3 ROBO1 MACF1 SRGAP2B CAPRIN1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

5.21e-0556911012GO:0034329
GeneOntologyBiologicalProcesspositive regulation of nervous system development

FZD3 ADGRB3 POU4F2 ASPM ROBO1 MACF1 PLAG1 CAPRIN1 EPHA4 EPHB1

8.11e-0541811010GO:0051962
GeneOntologyBiologicalProcessregulation of dendrite development

RAPGEF4 ADGRB3 CRTC1 ROBO1 CAPRIN1 EPHA4

1.54e-041501106GO:0050773
GeneOntologyCellularComponentGABA-A receptor complex

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.04e-08191105GO:1902711
GeneOntologyCellularComponentGABA receptor complex

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.00e-08211105GO:1902710
GeneOntologyCellularComponentleading edge membrane

KSR1 ROBO1 MACF1 ARHGEF4 ARHGAP45 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.65e-0721011010GO:0031256
GeneOntologyCellularComponentpostsynaptic specialization

FRMPD4 RAPGEF4 ADGRB3 CRTC1 SYN2 MACF1 IGSF21 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

2.46e-0650311013GO:0099572
GeneOntologyCellularComponentneuron projection membrane

ROBO1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.68e-06821106GO:0032589
GeneOntologyCellularComponentpostsynaptic specialization membrane

ADGRB3 IGSF21 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

1.13e-052011108GO:0099634
GeneOntologyCellularComponentdendrite membrane

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.14e-05561105GO:0032590
GeneOntologyCellularComponentchloride channel complex

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.24e-05571105GO:0034707
GeneOntologyCellularComponentcell projection membrane

KSR1 ROBO1 MACF1 ARHGEF4 EFCAB7 ARHGAP45 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.72e-0543111011GO:0031253
GeneOntologyCellularComponentcell leading edge

KSR1 ROBO1 MACF1 ARHGEF4 ARHGAP45 CAPRIN1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.64e-0550011011GO:0031252
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN5A SCN9A

9.14e-05171103GO:0001518
GeneOntologyCellularComponentdendrite

FRMPD4 FZD3 RAPGEF4 CRTC1 CNNM1 ROBO1 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

1.64e-0485811014GO:0030425
GeneOntologyCellularComponentdendritic tree

FRMPD4 FZD3 RAPGEF4 CRTC1 CNNM1 ROBO1 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

1.68e-0486011014GO:0097447
GeneOntologyCellularComponentintegrator complex

INTS3 INTS9 SAGE1

1.76e-04211103GO:0032039
GeneOntologyCellularComponentpostsynapse

FRMPD4 RAPGEF4 ADGRB3 CRTC1 SRGAP3 SYN2 MACF1 IGSF21 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

2.86e-04101811015GO:0098794
GeneOntologyCellularComponentglutamatergic synapse

FRMPD4 FZD3 RAPGEF4 ADGRB3 CRTC1 ATP8A1 SRGAP3 SCN2A SYN2 SRGAP2B CAPRIN1 EPHA4 EPHB1

3.63e-0481711013GO:0098978
GeneOntologyCellularComponentsodium channel complex

SCN2A SCN5A SCN9A

4.69e-04291103GO:0034706
GeneOntologyCellularComponentpresynaptic membrane

FZD3 SCN2A IGSF21 EPHA4 GABRA2 GABRA3 GABRA5

6.62e-042771107GO:0042734
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN2A SCN5A SCN9A GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

8.76e-043781108GO:0034702
GeneOntologyCellularComponentsynaptic membrane

FZD3 ADGRB3 SCN2A IGSF21 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

1.02e-0358311010GO:0097060
GeneOntologyCellularComponentinner dynein arm

DNAH2 DNAH6

1.20e-03101102GO:0036156
GeneOntologyCellularComponentpostsynaptic membrane

ADGRB3 IGSF21 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

1.36e-034051108GO:0045211
GeneOntologyCellularComponentGABA-ergic synapse

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.76e-031641105GO:0098982
GeneOntologyCellularComponenttransporter complex

ATP8A1 SCN2A SCN5A SCN9A GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.50e-035501109GO:1990351
GeneOntologyCellularComponentruffle membrane

KSR1 MACF1 ARHGEF4 ARHGAP45

2.56e-031081104GO:0032587
GeneOntologyCellularComponentpostsynaptic density

FRMPD4 RAPGEF4 ADGRB3 CRTC1 SYN2 MACF1 IGSF21 EPHA4

2.66e-034511108GO:0014069
GeneOntologyCellularComponentasymmetric synapse

FRMPD4 RAPGEF4 ADGRB3 CRTC1 SYN2 MACF1 IGSF21 EPHA4

3.73e-034771108GO:0032279
HumanPhenoEpilepsia partialis continua

POLG SCN2A SCN9A GABRA1

1.25e-0612384HP:0012847
HumanPhenoDysgenesis of the hippocampus

SCN2A SCN9A MACF1 GABRA1

4.50e-0616384HP:0025101
HumanPhenoFocal motor status epilepticus

POLG SCN2A SCN9A GABRA1

5.85e-0617384HP:0032663
HumanPhenoPhotosensitive myoclonic seizure

SCN2A SCN9A GABRA1

2.09e-058383HP:0001327
HumanPhenoCyanotic episode

SCN2A SCN9A GABRA1

2.09e-058383HP:0200048
HumanPhenoStatus epilepticus without prominent motor symptoms

POLG SCN2A SCN9A GABRA1

4.09e-0527384HP:0031475
HumanPhenoStatus epilepticus with prominent motor symptoms

POLG SCN2A SCN9A GABRA1

5.47e-0529384HP:0032658
HumanPhenoLimited neck range of motion

SCN2A SCN9A GABRA1

6.07e-0511383HP:0000466
HumanPhenoProgressive gait ataxia

POLG SCN2A SCN9A GABRA1

6.28e-0530384HP:0007240
HumanPhenoProgressive ataxia

POLG SCN2A SCN9A GABRA1

6.28e-0530384HP:0001329
HumanPhenoCogwheel rigidity

POLG SCN2A SCN9A GABRA1

8.15e-0532384HP:0002396
HumanPhenoObsessive-compulsive trait

SCN2A SCN9A SLC45A1 GABRA1

9.23e-0533384HP:0008770
HumanPhenoLimitation of neck motion

MYH7 SCN2A SCN9A GABRA1

1.31e-0436384HP:0005986
HumanPhenoAbnormal neck physiology

MYH7 SCN2A SCN9A GABRA1

1.31e-0436384HP:0025669
HumanPhenoFacial tics

SCN2A SCN9A GABRA1

1.64e-0415383HP:0011468
HumanPhenoSecond degree atrioventricular block

LARS2 SCN5A GABRA3

1.64e-0415383HP:0011706
HumanPhenoPhotosensitive tonic-clonic seizure

SCN2A SCN9A GABRA1

1.64e-0415383HP:0007207
HumanPhenoComplex febrile seizure

SCN2A SCN9A GABRA1

2.01e-0416383HP:0011172
HumanPhenoVisually-induced seizure

SCN2A SCN9A GABRA1

2.89e-0418383HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

POLG SCN2A SCN9A

2.89e-0418383HP:0032860
HumanPhenoDisordered formal thought process

NAT8L NSD2 POLG HUWE1 ASXL3 SCN2A SCN9A MACF1 SLC45A1 GABRA1

3.82e-043863810HP:0025769
HumanPhenoNon-convulsive status epilepticus without coma

POLG SCN2A SCN9A

4.00e-0420383HP:0032671
HumanPhenoAbnormal hippocampus morphology

SCN2A SCN9A MACF1 GABRA1

4.05e-0448384HP:0025100
HumanPhenoAbnormal morphology of the limbic system

SCN2A SCN9A MACF1 GABRA1

4.39e-0449384HP:0007343
HumanPhenoAllodynia

POLG SCN9A

5.34e-045382HP:0012533
HumanPhenoReflex seizure

SCN2A SCN9A GABRA1

5.35e-0422383HP:0020207
HumanPhenoBilateral tonic-clonic seizure with generalized onset

SCN2A SCN9A GABRA1 GABRA5

5.52e-0452384HP:0025190
MousePhenoabnormal GABA-mediated receptor currents

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.68e-0818875MP:0004008
MousePhenoshortened circadian behavior period

POU4F2 ADCYAP1R1 ZFHX3 ANKFN1

1.88e-0526874MP:0020470
MousePhenoabnormal circadian behavior period

POU4F2 ADCYAP1R1 ZFHX3 ANKFN1

7.08e-0536874MP:0020468
MousePhenoabnormal CNS synaptic transmission

LGMN FZD3 PPARA ADCYAP1R1 KSR1 SRGAP3 SCN2A SCN9A SYN2 IGSF21 CAPRIN1 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5

1.02e-049858717MP:0002206
DomainGABAAa_rcpt

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.35e-1161075IPR001390
DomainGABAA/Glycine_rcpt

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.74e-07231075IPR006028
DomainNa_trans_cytopl

SCN2A SCN5A SCN9A

3.61e-0661073PF11933
DomainNa_trans_cytopl

SCN2A SCN5A SCN9A

3.61e-0661073IPR024583
DomainNeurotransmitter_ion_chnl_CS

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.72e-06451075IPR018000
DomainNeur_chan_memb

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.39e-06461075PF02932
DomainNeurotrans-gated_channel_TM

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-06471075IPR006029
Domain-

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-064710752.70.170.10
DomainNeur_chan_LBD

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-06471075PF02931
DomainNEUROTR_ION_CHANNEL

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-06471075PS00236
DomainNeur_channel

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-06471075IPR006201
DomainNeur_chan_lig-bd

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

7.12e-06471075IPR006202
DomainNa_channel_asu

SCN2A SCN5A SCN9A

2.13e-05101073IPR001696
DomainNa_trans_assoc

SCN2A SCN5A SCN9A

2.13e-05101073IPR010526
DomainNa_trans_assoc

SCN2A SCN5A SCN9A

2.13e-05101073PF06512
DomainIQ

MYH7 SCN2A SCN5A SCN9A ASPM

1.02e-04811075SM00015
DomainIQ_motif_EF-hand-BS

MYH7 SCN2A SCN5A SCN9A ASPM

1.68e-04901075IPR000048
DomainIQ

MYH7 SCN2A SCN5A SCN9A ASPM

1.96e-04931075PS50096
DomainFCH

SRGAP3 SRGAP2B ARHGAP45

2.60e-04221073SM00055
DomainFCH_dom

SRGAP3 SRGAP2B ARHGAP45

2.98e-04231073IPR001060
DomainF_BAR

SRGAP3 SRGAP2B ARHGAP45

3.84e-04251073IPR031160
DomainF_BAR

SRGAP3 SRGAP2B ARHGAP45

3.84e-04251073PS51741
DomainIGv

BTN3A2 BTN3A1 BTN3A3 ROBO1

9.05e-04751074SM00406
Domain-

ADAMTSL3 BTN3A2 BTN3A1 BTN3A3 NFATC2 ROBO1 OSMR IGSF21 ANKFN1 EPHA4 EPHB1

1.47e-03663107112.60.40.10
DomainIg-like_fold

ADAMTSL3 BTN3A2 BTN3A1 BTN3A3 NFATC2 ROBO1 OSMR IGSF21 ANKFN1 EPHA4 EPHB1

2.40e-0370610711IPR013783
Domainfn3

ROBO1 OSMR ANKFN1 EPHA4 EPHB1

2.41e-031621075PF00041
DomainRECEPTOR_TYR_KIN_V_2

EPHA4 EPHB1

2.83e-03141072PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHA4 EPHB1

2.83e-03141072PS00790
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH6

2.83e-03141072IPR024317
DomainTyr_kinase_rcpt_V_CS

EPHA4 EPHB1

2.83e-03141072IPR001426
DomainDynein_HC_stalk

DNAH2 DNAH6

2.83e-03141072IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH6

2.83e-03141072IPR013602
DomainDHC_N2

DNAH2 DNAH6

2.83e-03141072PF08393
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH6

2.83e-03141072IPR011704
DomainEphA2_TM

EPHA4 EPHB1

2.83e-03141072PF14575
DomainEphrin_rcpt_lig-bd_dom

EPHA4 EPHB1

2.83e-03141072IPR001090
DomainEph_TM

EPHA4 EPHB1

2.83e-03141072IPR027936
DomainEPH_lbd

EPHA4 EPHB1

2.83e-03141072SM00615
DomainEphrin_lbd

EPHA4 EPHB1

2.83e-03141072PF01404
DomainMT

DNAH2 DNAH6

2.83e-03141072PF12777
DomainAAA_8

DNAH2 DNAH6

2.83e-03141072PF12780
DomainTyr_kinase_ephrin_rcpt

EPHA4 EPHB1

2.83e-03141072IPR016257
DomainEPH_LBD

EPHA4 EPHB1

2.83e-03141072PS51550
DomainAAA_5

DNAH2 DNAH6

2.83e-03141072PF07728
DomainDHC_fam

DNAH2 DNAH6

3.25e-03151072IPR026983
DomainDynein_heavy

DNAH2 DNAH6

3.25e-03151072PF03028
DomainDynein_heavy_dom

DNAH2 DNAH6

3.25e-03151072IPR004273
DomainARM-type_fold

PPP4R1 CUL9 NCBP1 HUWE1 ARFGEF3 ASPM LRBA

3.38e-033391077IPR016024
DomainFN3

ROBO1 OSMR ANKFN1 EPHA4 EPHB1

4.25e-031851075SM00060
DomainChannel_four-helix_dom

SCN2A SCN5A SCN9A

4.27e-03571073IPR027359
Domain-

SCN2A SCN5A SCN9A

4.27e-035710731.20.120.350
DomainGPCR_2_secretin-like

FZD3 ADGRB3 ADCYAP1R1

4.94e-03601073IPR000832
DomainGPCR_2-like

FZD3 ADGRB3 ADCYAP1R1

4.94e-03601073IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD3 ADGRB3 ADCYAP1R1

5.17e-03611073PS50261
DomainMyosin-like_IQ_dom

MYH7 ASPM

5.22e-03191072IPR027401
Domain-

MYH7 ASPM

5.22e-031910724.10.270.10
PathwayBIOCARTA_FLUMAZENIL_PATHWAY

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.11e-099895M22034
PathwayBIOCARTA_GABA_PATHWAY

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.20e-0910895M477
PathwayBIOCARTA_GABA_PATHWAY

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.20e-0910895MM1401
PathwayWP_GABA_RECEPTOR_SIGNALING

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.34e-0631895M39369
PathwayWP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.81e-0638895M39854
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.72e-0560895MM15708
PathwayREACTOME_GABA_RECEPTOR_ACTIVATION

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.72e-0560895M976
PathwayREACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS

BTN3A2 BTN3A1 BTN3A3

5.14e-0512893M27738
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

GLS2 SYN2 PLCB2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.51e-05211898MM14502
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

PLCB2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.96e-04144896MM14501
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

GLS2 SYN2 PLCB2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.02e-04270898M15514
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GLS2 SCN2A SCN5A SCN9A GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.06e-04367899M48346
Pubmed

GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in mice.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.98e-126113520457185
Pubmed

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.

GABRA1 GABRA2 GABRA3 GABRA5

1.06e-104113425865415
Pubmed

Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.51e-101111359924185
Pubmed

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.51e-1011113538894703
Pubmed

Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.17e-1013113522569571
Pubmed

Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.17e-1013113522640814
Pubmed

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

GABRA1 GABRA2 GABRA3 GABRA5

5.27e-105113430104684
Pubmed

Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5.

GABRA1 GABRA2 GABRA3 GABRA5

1.58e-096113415033447
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.74e-0918113519078961
Pubmed

Developmental changes in the expression of gamma-aminobutyric acidA/benzodiazepine receptor subunit mRNAs in the murine inferior olivary complex.

GABRA2 GABRA3 GABRA4 GABRA5

3.67e-09711347560270
Pubmed

Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia.

GABRA1 GABRA2 GABRA3 GABRA5

3.67e-097113420843900
Pubmed

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO).

GABRA1 GABRA2 GABRA3 GABRA5

3.67e-097113435228700
Pubmed

Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.46e-0921113525708312
Pubmed

gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.

GABRA1 GABRA2 GABRA3 GABRA4

7.32e-09811348175718
Pubmed

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.

GABRA1 GABRA3 GABRA4 GABRA5

7.32e-098113418185516
Pubmed

Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons.

GABRA1 GABRA2 GABRA3 GABRA5

2.19e-0810113436733270
Pubmed

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.

GABRA1 GABRA2 GABRA3 GABRA4

2.19e-0810113421789198
Pubmed

Specific GABAA circuits for visual cortical plasticity.

GABRA1 GABRA2 GABRA3

3.34e-083113315017002
Pubmed

Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.

GABRA1 GABRA2 GABRA3

3.34e-083113316835366
Pubmed

Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits.

GABRA1 GABRA2 GABRA3

3.34e-083113315304513
Pubmed

The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.

GABRA1 GABRA2 GABRA3

3.34e-08311331356407
Pubmed

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.

BTN3A2 BTN3A1 BTN3A3

3.34e-083113322767497
Pubmed

The biochemical anatomy of cortical inhibitory synapses.

GABRA1 GABRA3 GABRA4 GABRA5

1.03e-0714113422768092
Pubmed

The α1, α2, α3, and γ2 subunits of GABAA receptors show characteristic spatial and temporal expression patterns in rhombencephalic structures during normal human brain development.

GABRA1 GABRA2 GABRA3

1.33e-074113326518133
Pubmed

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.

BTN3A2 BTN3A1 BTN3A3

1.33e-074113339142074
Pubmed

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.

GABRA1 GABRA2 GABRA3

1.33e-074113325080596
Pubmed

Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex.

GABRA1 GABRA3 GABRA5

1.33e-074113320692323
Pubmed

GABA(A) receptor downregulation in brains of subjects with autism.

GABRA1 GABRA2 GABRA3

1.33e-074113318821008
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

ADCYAP1R1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.74e-0781113622723691
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

GABRA1 GABRA2 GABRA3 GABRA4

3.12e-0718113418985723
Pubmed

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

BTN3A2 BTN3A1 BTN3A3

3.32e-075113329339503
Pubmed

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.

GABRA1 GABRA2 GABRA5

6.63e-076113321751815
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PPP4R1 ZCCHC8 POLG RAPGEF4 ADGRB3 CUL9 NCBP1 NCAPH2 STAM HUWE1 CRYL1 KHDRBS1 ZBTB5 ROBO1 MACF1 LRBA CAPRIN1

8.93e-0712851131735914814
Pubmed

Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.

GABRA2 GABRA4 GABRA5

1.16e-067113316080114
Pubmed

Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.

GABRA1 GABRA2 GABRA5

1.16e-067113317021187
Pubmed

Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.

GABRA1 GABRA2 GABRA3

1.16e-067113316101898
Pubmed

The cluster of BTN genes in the extended major histocompatibility complex.

BTN3A2 BTN3A1 BTN3A3

1.16e-067113311170752
Pubmed

GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.

GABRA1 GABRA2 GABRA3

1.85e-068113311528422
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN5A SCN9A

2.77e-069113316382098
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

NAT8L ZCCHC8 NCBP1 KHDRBS1 ASPM INTS9 NDUFAF6 CAPRIN1 GABRA1 GABRA4

2.85e-064621131031138677
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

FRMPD4 ADGRB3 ARFGEF3 MACF1 GABRA1 GABRA2 GABRA3

3.91e-06197113736604605
Pubmed

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

GABRA1 GABRA2 GABRA3

7.19e-061211332561974
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN5A SCN9A

9.33e-0613113315123669
Pubmed

GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study.

GABRA3 GABRA5

1.05e-052113211378843
Pubmed

Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward.

GABRA2 GABRA3

1.05e-052113222763624
Pubmed

Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

GABRA2 GABRA3

1.05e-052113223147414
Pubmed

α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations.

GABRA1 GABRA2

1.05e-052113223109109
Pubmed

Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala.

GABRA2 GABRA3

1.05e-052113222666188
Pubmed

Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice.

GABRA1 GABRA5

1.05e-052113227155990
Pubmed

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.

GABRA2 GABRA3

1.05e-05211328391122
Pubmed

GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.

GABRA1 GABRA2

1.05e-052113218973555
Pubmed

Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies.

GABRA1 GABRA5

1.05e-052113231056671
Pubmed

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

NFATC2 SCN5A

1.05e-052113232778883
Pubmed

Reversal of pathological pain through specific spinal GABAA receptor subtypes.

GABRA2 GABRA3

1.05e-052113218202657
Pubmed

Novel variants in GABAA receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy.

GABRA2 GABRA5

1.05e-052113236469977
Pubmed

Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference.

GABRA2 GABRA5

1.05e-052113226446222
Pubmed

Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.

SCN2A SCN5A

1.05e-052113216847056
Pubmed

Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.

GABRA1 GABRA3

1.05e-05211329655866
Pubmed

Transient expression of GABAA receptor alpha2 and alpha3 subunits in differentiating cerebellar neurons.

GABRA2 GABRA3

1.05e-052113214766194
Pubmed

Molecular and neuronal substrate for the selective attenuation of anxiety.

GABRA2 GABRA3

1.05e-052113211021797
Pubmed

Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.

BTN3A2 BTN3A1

1.05e-052113221918970
Pubmed

The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.

BTN3A2 BTN3A1

1.05e-052113222846996
Pubmed

The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.

GABRA1 GABRA5

1.05e-052113219457072
Pubmed

Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.

SCN5A SCN9A

1.05e-052113226861708
Pubmed

Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of alpha1 and alpha2 subunits of GABA(A) receptor in newborn rat.

GABRA1 GABRA2

1.05e-052113218085262
Pubmed

Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice.

PPARA HUWE1

1.05e-052113236933792
Pubmed

Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.

GABRA2 GABRA3

1.05e-052113224553732
Pubmed

Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling.

GABRA1 GABRA2

1.05e-052113221073549
Pubmed

Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.

GABRA1 GABRA3

1.05e-052113223744069
Pubmed

Functional mapping of GABA A receptor subtypes in the amygdala.

GABRA2 GABRA3

1.05e-052113215341600
Pubmed

Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

GABRA1 GABRA2

1.05e-052113221056629
Pubmed

CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.

BTN3A2 BTN3A1

1.05e-052113221113407
Pubmed

Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

GABRA2 GABRA4

1.05e-052113219207358
Pubmed

Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist.

GABRA1 GABRA5

1.05e-052113216253225
Pubmed

Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat.

GABRA2 GABRA3

1.05e-052113223067879
Pubmed

Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.

GABRA2 GABRA3

1.05e-052113226973458
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NSD2 POLG MAML1 CUL9 PPARA HUWE1 LARS2 BTN3A2 MICALL1 SCN5A NLRC5 ARHGEF4 SLC45A1 LRBA

1.45e-0511051131435748872
Pubmed

A 1.1-Mb transcript map of the hereditary hemochromatosis locus.

BTN3A2 BTN3A1 BTN3A3

2.63e-051811339149941
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN9A

3.13e-053113219284629
Pubmed

The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis.

ZCCHC8 NCBP1

3.13e-053113225578728
Pubmed

Diagnostic outcomes for genetic testing of 70 genes in 8565 patients with epilepsy and neurodevelopmental disorders.

SCN2A GABRA1

3.13e-053113229655203
Pubmed

Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.

PPARA HUWE1

3.13e-053113229331071
Pubmed

PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα.

PPARA HUWE1

3.13e-053113234474167
Pubmed

Investigation of autism and GABA receptor subunit genes in multiple ethnic groups.

GABRA1 GABRA4

3.13e-053113216770606
Pubmed

The effects of the nonselective benzodiazepine lorazepam and the α2 /α3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels.

GABRA2 GABRA3

3.13e-053113227128218
Pubmed

Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system of the mouse.

EPHA4 EPHB1

3.13e-05311327609620
Pubmed

De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.

GABRA2 GABRA5

3.13e-053113229961870
Pubmed

Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.

GABRA2 GABRA4

3.13e-053113229135068
Pubmed

Gene expression meta-analysis reveals the down-regulation of three GABA receptor subunits in the superior temporal gyrus of patients with schizophrenia.

GABRA1 GABRA2

3.13e-053113232376074
Pubmed

Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.

NSD2 NLRC5

3.13e-053113235230972
Pubmed

Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus.

GABRA1 GABRA4

3.13e-053113224027285
Pubmed

Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis.

RNF213 NFATC2

3.13e-053113234584155
Pubmed

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.

GABRA1 GABRA2

3.13e-053113218063661
Pubmed

Calmodulin mediates Ca2+ sensitivity of sodium channels.

SCN2A SCN5A

3.13e-053113215316014
Pubmed

Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.

GABRA2 GABRA4

3.13e-053113218482426
Pubmed

GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.

GABRA1 GABRA2

3.13e-053113218818659
Pubmed

Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.

GABRA2 GABRA4

3.13e-053113224948817
Pubmed

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.

GABRA2 GABRA4

3.13e-053113221722213
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN5A SCN9A

3.13e-053113220038812
Pubmed

GABAA receptor subunits in the human amygdala and hippocampus: Immunohistochemical distribution of 7 subunits.

GABRA1 GABRA3

3.13e-053113229023704
InteractionGABRA5 interactions

GABRA1 GABRA3 GABRA5

1.44e-0651073int:GABRA5
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.00e-0819835563
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN5A SCN9A

7.68e-0698331203
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN3A2 BTN3A1 BTN3A3

4.08e-0515833458
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP3 SRGAP2B ARHGAP45

1.55e-04238331288
GeneFamilyFibronectin type III domain containing

ROBO1 OSMR ANKFN1 EPHA4 EPHB1

8.49e-04160835555
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHA4 EPHB1

1.83e-03148321095
GeneFamilyIntegrator complex

INTS3 INTS9

2.10e-03158321366
GeneFamilyDyneins, axonemal

DNAH2 DNAH6

2.71e-0317832536
CoexpressionMARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6

NSD2 KHDRBS1 PLCB2 SLC45A1 MBNL3

1.73e-06471125M1652
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

NSD2 ST8SIA1 CNNM1 ATP8A1 SRGAP3 MACF1 CDC25B

1.27e-051801127M8239
CoexpressionAtlasBM Top 100 - frontal lobe

RAPGEF4 SCN2A SYN2 GABRA1 GABRA2 GABRA4 GABRA5

8.12e-08721087BM Top 100 - frontal lobe
CoexpressionAtlasBM Top 100 - temporal lobe

RAPGEF4 SCN2A SYN2 GABRA1 GABRA2 GABRA4 GABRA5

9.84e-08741087BM Top 100 - temporal lobe
CoexpressionAtlasBM Top 100 - amygdala

RAPGEF4 SCN2A SYN2 GABRA1 GABRA2 GABRA5

1.94e-06731086BM Top 100 - amygdala
CoexpressionAtlascerebral cortex

NAT8L SCHIP1 FRMPD4 RAPGEF4 ADGRB3 ADCYAP1R1 ARFGEF3 CNNM1 SRGAP3 SCN2A SYN2 PLPP4 ARHGEF4 SLC45A1 IGSF21 GABRA1 EPHA4 GABRA2 GABRA3 GABRA4 GABRA5 EPHB1

2.49e-06142810822cerebral cortex
CoexpressionAtlasBM Top 100 - hippocampus

RAPGEF4 SCN2A SYN2 EPHA4 GABRA2 GABRA5

2.87e-06781086BM Top 100 - hippocampus
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_1000

CA12 LGMN SCHIP1 GBP7 FZD3 ST8SIA1 HUWE1 ATP8A1 KHDRBS1 ASXL3 OSMR VEGFD EPHA4 GABRA4 EPHB1

2.16e-0583610815gudmap_developingKidney_e15.5_Podocyte cells_1000
CoexpressionAtlasBM Top 100 - occipital lobe

SCN2A SYN2 GABRA1 GABRA2 GABRA4

3.54e-05731085BM Top 100 - occipital lobe
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#3_top-relative-expression-ranked_1000

ADGRB3 ST8SIA1 KHDRBS1 ASXL3 SCN2A OSMR VEGFD GABRA1

4.22e-052501088gudmap_developingKidney_e13.5_podocyte cells_1000_k3
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_500

ST8SIA1 HUWE1 FIGN ATP8A1 KHDRBS1 ASXL3 OSMR VEGFD MBNL3 GABRA1

5.80e-0542110810gudmap_developingKidney_e15.5_Peripheral blastema_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

RAPGEF4 ADGRB3 ST8SIA1 HUWE1 ATP8A1 ASXL3 ASPM SYN2 ROBO1 PLAG1 CAPRIN1 GABRA1 EPHA4 GABRA3

6.90e-0581810814DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_1000

CA12 LGMN ADGRB3 ST8SIA1 HUWE1 INTS3 KHDRBS1 ASXL3 SCN2A OSMR VEGFD GABRA1 GABRA4 EPHB1

1.10e-0485510814gudmap_developingKidney_e13.5_podocyte cells_1000
CoexpressionAtlasdev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#3_top-relative-expression-ranked_1000

RNF213 ST8SIA1 SRGAP3 MBNL3 GABRA4

1.38e-04971085gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#3_top-relative-expression-ranked_500

FIGN ASXL3 ROBO1 EPHA4 GABRA4

1.83e-041031085gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000

ETV3 NCBP1 HUWE1 FIGN KHDRBS1 OGFOD1 ROBO1 ZFHX3 EPHA4 GABRA4

2.07e-0449210810gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_500

CA12 LGMN SCHIP1 ST8SIA1 KHDRBS1 OSMR EPHA4 GABRA4 EPHB1

2.71e-044151089gudmap_developingKidney_e15.5_Podocyte cells_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#3_top-relative-expression-ranked_500

ETV3 NCBP1 KHDRBS1 ROBO1 ZFHX3 EPHA4 GABRA4

2.86e-042491087gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500_k3
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000

RNF213 ST8SIA1 PPP2R3A KHDRBS1 SRGAP3 ASXL3 SCN2A ASPM ROBO1 PLAG1 VEGFD MBNL3 GABRA4

3.07e-0483110813gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_500

CA12 ADGRB3 ST8SIA1 INTS3 KHDRBS1 ASXL3 SCN2A OSMR EPHB1

3.58e-044311089gudmap_developingKidney_e13.5_podocyte cells_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000

ETV3 NCBP1 STAM HUWE1 FIGN KHDRBS1 ASXL3 OGFOD1 ROBO1 ZFHX3 GABRA1 EPHA4 GABRA4

3.81e-0485010813gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

RNF213 SRGAP3 SCN2A MBNL3 GABRA4

4.48e-041251085gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k1_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#5_top-relative-expression-ranked_500

RAPGEF4 ETV3 HUWE1 GABRA4

4.48e-04701084gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

HUWE1 FIGN ASXL3 ROBO1 ZFHX3 GABRA1

4.63e-041931086gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000_k1
CoexpressionAtlasBM Top 100 - cerebral cortex

SCN2A SYN2 GABRA1 GABRA2

4.99e-04721084BM Top 100 - cerebral cortex
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000

PPP4R1 LGMN SCHIP1 FZD3 RAPGEF4 RNF213 ST8SIA1 CRYL1 ATP8A1 SRGAP3 ROBO1 PLCB2 ARHGEF4

5.28e-0488010813gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlaskidney_adult_RenalCapsule_k-means-cluster#3_top-relative-expression-ranked_100

OSMR VEGFD

5.29e-0471082gudmap_kidney_adult_RenalCapsule_k3_100
ToppCellhealthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 NLRC5 MACF1 CDC25B

3.89e-081961138af00c31612e4fe068e5fccae05368edba46bbd20
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 NLRC5 MACF1 CDC25B

4.05e-081971138836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellhealthy_donor-Lymphocytic|healthy_donor / Disease condition, Lineage, Cell class and subclass

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 NLRC5 MACF1 CDC25B

4.38e-0819911382841e16d54acd344ba454f024e285c28abc37319
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1 ARHGAP45

3.52e-071771137d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1 ARHGAP45

3.52e-071771137f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1 ARHGAP45

3.52e-0717711376978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1 ARHGAP45

3.52e-071771137936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1 ARHGAP45

3.52e-071771137d5aeda113afaa2425874394610344570c9078478
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RNF213 ST8SIA1 HUWE1 ATP8A1 MACF1 SRGAP2B LRBA

4.09e-071811137f2315414e714ac86211546a935660c4be6e85f1b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRMPD4 FIGN ARFGEF3 ASXL3 SCN2A SCN9A ROBO1

4.57e-0718411372cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRMPD4 FIGN ARFGEF3 ASXL3 SCN2A SCN9A ROBO1

4.57e-071841137ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRMPD4 FIGN ARFGEF3 ASXL3 SCN2A SCN9A ROBO1

4.57e-0718411372b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

4.92e-071861137a07694caf7fede06a47636725bcc7f09909cdf07
ToppCellcontrol-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

5.10e-071871137c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

5.29e-07188113726405ef1b934744e672c642db78834c21d3ba28f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SCN2A SCN9A ROBO1 ZFHX3 GABRA1 EPHA4 GABRA5

5.68e-0719011376e92c78799f34b31d098854503c796edb0dc7f80
ToppCell(011)_pDC|World / immune cells in Peripheral Blood (logTPM normalization)

LGMN NAT8L FZD3 ADGRB3 SCN9A PROC EPHB1

5.88e-071911137d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCellMNPs-Dendritic_Cells|MNPs / lung cells shred on cell class, cell subclass, sample id

RAPGEF4 TLR10 NFATC2 SRGAP3 ARHGAP45 IGSF21 PROC

6.31e-0719311370e6b8e179bfe1c6e93137c76c76a91c7782a4989
ToppCellPosterior_cortex-Neuronal|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ST8SIA1 ARFGEF3 CNNM1 SCN2A SYN2 SLC45A1 GABRA1

6.31e-071931137b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCellcontrol-pDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

6.31e-07193113730a6559c9a9e8941861cb259b4836acccc427e68
ToppCellsevere-pDC|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

7.49e-07198113722da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCellsevere-pDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LGMN NAT8L SCHIP1 FZD3 SCN9A PROC EPHB1

7.49e-0719811373c4820a8391088682fb3e47b914f872533bae227
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RNF213 GSAP BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

7.74e-071991137df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

RNF213 GSAP BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

7.74e-071991137ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

RNF213 HUWE1 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

8.01e-0720011372281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ADGRB3 NCBP1 SCN9A PLAG1 NOP2 PROC

1.21e-0613411360e3f37ef041b751ed45060b5ce39385a2731370b
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

CA12 CCDC168 SRGAP3 SCN2A SCN9A OSMR

2.25e-061491136d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

RNF213 BTN3A1 ATP8A1 NFATC2 NLRC5 MACF1

2.94e-061561136afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellInfluenza_Severe-pDC|Influenza_Severe / Disease group and Cell class

LGMN FZD3 ADGRB3 SCN9A PROC EPHB1

4.20e-061661136b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCellmild_COVID-19_(asymptomatic)-pDC|World / disease group, cell group and cell class (v2)

LGMN NAT8L ADGRB3 SCN9A PROC EPHB1

4.35e-061671136bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

LGMN NAT8L ADGRB3 SCN9A PROC EPHB1

4.50e-061681136968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

FRMPD4 ADGRB3 ADAMTSL3 ADCYAP1R1 SCN9A VEGFD

4.66e-06169113641cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCellTCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue|TCGA-Colorectal / Sample_Type by Project: Shred V9

FRMPD4 ADGRB3 ADAMTSL3 ADCYAP1R1 SCN9A VEGFD

4.66e-06169113691f4b6a14708e701b2af22989004282041777491
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

LGMN NAT8L SCHIP1 SCN9A PROC EPHB1

5.88e-0617611365de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST8SIA1 SCN5A ASPM DNAH6 GABRA1 EPHB1

6.48e-061791136c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ERICH1 PPARA ARFGEF3 PPP2R3A LRBA

6.68e-0618011369e09b3dfe344b5d50520711513d389865d73a861
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L FZD3 SCN9A PROC EPHB1

7.12e-0618211369bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L FZD3 SCN9A PROC EPHB1

7.12e-0618211364602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 PPARA ARFGEF3 CRYL1 PPP2R3A LRBA

7.82e-06185113603f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L SCHIP1 SCN9A PROC EPHB1

7.82e-0618511363091870a5bf8ecb963e560b47c8502bae367416c
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

LGMN NAT8L FZD3 SCN9A PROC EPHB1

7.82e-0618511367fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 PPP2R3A SRGAP3 SCN2A PLPP4 GABRA2

8.06e-06186113608632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 PPARA ARFGEF3 CRYL1 PPP2R3A LRBA

8.06e-0618611361850583d23903d08226aeb0edb3e07b0994330e4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ERICH1 NAT8L PPARA ARFGEF3 CRYL1

8.31e-06187113685e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ERICH1 NAT8L PPARA ARFGEF3 CRYL1

8.31e-06187113652b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GBP7 RAPGEF4 RNF213 SCN9A NLRC5 CDC25B

8.31e-061871136f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

LGMN NAT8L FZD3 SCN9A PROC EPHB1

8.31e-061871136aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL3 SRGAP3 SCN2A PLPP4 GABRA2 EPHB1

8.31e-061871136e3095455d2f255854f339f6b05fa87852af0700f
ToppCell(0)_Myeloid-(011)_pDC|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)

LGMN NAT8L FZD3 SCN9A PROC EPHB1

8.57e-061881136a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RNF213 HUWE1 ATP8A1 OTULIN MACF1 LRBA

8.57e-061881136ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19_Mild-pDC|COVID-19_Mild / Disease condition and Cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

8.57e-06188113662d33d2990d4a2d32bd0863147e47f656df1966e
ToppCellCOVID-19_Mild-pDC-|COVID-19_Mild / Disease condition and Cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

8.57e-061881136a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCellMS-pDC-|MS / Condition, Cell_class and T cell subcluster

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.10e-061901136f56ec302d556ace4f7609017a35c311cf43aa8a5
ToppCellMS-pDC|MS / Condition, Cell_class and T cell subcluster

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.10e-061901136f41d7ab7d7fbcd73fddb6c3533c6a3e642e3d07f
ToppCellCOVID-19_Moderate-pDC|World / disease group, cell group and cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.38e-06191113693adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.38e-0619111368c487704cbbb5eeff54e8c6fb6fffa1472b5351f
ToppCellControl-pDC|Control / Disease condition and Cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.38e-061911136543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCellsystemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.38e-06191113678d523f562d32fc408a20d99b0c61cc103241bc0
ToppCellControl-pDC-|Control / Disease condition and Cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.38e-0619111361d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NSD2 LARS2 MACF1 ZFHX3 ARHGAP45 CAPRIN1

9.66e-0619211361ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellHealthy-pDC|Healthy / disease group, cell group and cell class

LGMN NAT8L FZD3 SCN9A PROC EPHB1

9.66e-06192113633d695a28d22b4af111df9591830a33bb7ef7b2d
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRMPD4 ADGRB3 ST8SIA1 ASXL3 ROBO1 VEGFD

9.95e-061931136fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRMPD4 ADGRB3 ST8SIA1 ASXL3 ROBO1 OSMR

1.02e-05194113689b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell3'_v3-Lung-Myeloid_Dendritic|Lung / Manually curated celltypes from each tissue

ETV3 TLR10 SCN9A IGSF21 PROC EPHB1

1.06e-051951136b748cb15846345363e8c2ee5936bb42bba3ba9a7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN NFATC2 PLCB2 SRGAP2B ARHGAP45 IGSF21

1.06e-05195113642bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.06e-0519511369990440bda7fac5d00ef80444fab07459be625e1
ToppCellcritical-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RNF213 BTN3A2 ATP8A1 OTULIN SRGAP3 MACF1

1.09e-051961136c861f017aa9050282aa81c5a445bae399df00e4f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD4 RAPGEF4 ADGRB3 SCN2A SYN2 GABRA1

1.09e-051961136676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.09e-051961136418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.09e-051961136581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.09e-0519611366beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 PPARA CRYL1 PPP2R3A SRGAP3 LRBA

1.09e-051961136eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.09e-051961136c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

LGMN NFATC2 SRGAP3 SCN9A ARHGAP45 IGSF21

1.09e-051961136e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCellT_cells-CTLs|World / Immune cells in Kidney/Urine in Lupus Nephritis

BTN3A2 BTN3A1 NFATC2 NLRC5 MACF1 CDC25B

1.12e-0519711362de34e20915a247bee75aa40495e23c20bb23e18
ToppCellCOVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.12e-051971136d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD4 RAPGEF4 ADGRB3 SCN2A SYN2 GABRA1

1.15e-051981136c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD4 RAPGEF4 SCN2A SYN2 GABRA1 GABRA4

1.15e-0519811366d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD4 RAPGEF4 SCN2A SYN2 GABRA1 GABRA4

1.15e-0519811364ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellBAL-Severe-cDC_10|Severe / Compartment, Disease Groups and Clusters

ERICH1 ETV3 NEU3 ST8SIA1 ATP8A1 TBC1D10A

1.18e-05199113654bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GLS2 FRMPD4 CNNM1 SCN2A GABRA1 GABRA5

1.22e-0520011362f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GLS2 FRMPD4 CNNM1 SCN2A GABRA1 GABRA5

1.22e-052001136bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCellControl-Control-Lymphocyte-T/NK-CD8+_Tem|Control / Disease, condition lineage and cell class

RNF213 BTN3A2 BTN3A1 ATP8A1 NFATC2 CDC25B

1.22e-052001136fddb3df5b90eb97ef8ed80fac320c1a90903f012
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GLS2 FRMPD4 CNNM1 SCN2A GABRA1 GABRA5

1.22e-052001136dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T|COVID-19_Severe / Disease, condition lineage and cell class

RNF213 BTN3A2 BTN3A1 BTN3A3 NFATC2 MACF1

1.22e-052001136f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD8-positive,_alpha-beta_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ST8SIA1 NFATC2 ASPM PLAG1 LRBA

2.53e-0513611359d7080f695de4ef183e3dbdc18ba464a3b8e3469
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ZBTB26 CNNM1 SRGAP3 OR51I2 ANKFN1

2.62e-05137113548c21e6938a46e3cd74ac10b8ace0a4751741af7
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DRC7 ST8SIA1 ROPN1L ANKFN1 DNAH6

4.18e-0515111359d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ADAMTSL3 PPP2R3A SCN2A PLPP4

4.31e-051521135eee86b508b8f140ea44e21d8c04c409a7b689e39
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 DNAH2 ROPN1L ANKFN1 DNAH6

4.59e-0515411354e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 DNAH2 ROPN1L ANKFN1 DNAH6

4.59e-0515411357556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellAdult-Epithelial-basal_cell-D122|Adult / Lineage, Cell type, age group and donor

FRMPD4 SRGAP3 ASXL3 GABRA1 GABRA5

4.59e-05154113538d346402417960044ae999e61f0092b46f2b591
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 DNAH2 ROPN1L ANKFN1 DNAH6

4.73e-0515511355f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 DNAH2 ROPN1L ANKFN1 DNAH6

4.73e-0515511350944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

TLR10 ZNF43 SCN9A PROC EPHB1

4.88e-05156113519472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

ST8SIA1 ATP8A1 LRBA OSMR ANKFN1

4.88e-05156113510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellBronchus_Control_(B.)-Endothelial-TX-Endothelial-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

BTN3A2 TBC1D10A ZBTB5 EFCAB7

5.41e-05811134a1193b2cfb84a6b6593779fef5f54a61567a12d7
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP8A1 NFATC2 ASXL3 LRBA GABRA4

5.50e-0516011358e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Lung / Manually curated celltypes from each tissue

FZD3 ZBTB26 FSIP2 PLAG1 NOP2

5.50e-0516011359f7f24a52a24fb926df69c8e5aad64ee75a66ef1
ToppCelldroplet-Liver-Npc-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN NAT8L FZD3 GDF3 ADCYAP1R1

5.50e-05160113585205dc68369d3e04df3460c1f3861ee2dc242a9
ComputationalNeighborhood of CASP8

BTN3A2 BTN3A1 BTN3A3 ARHGAP45

3.22e-0527744GNF2_CASP8
ComputationalGenes in the cancer module 141.

GABRA1 GABRA2 GABRA5

1.64e-0416743MODULE_141
DrugMeprobamate

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.57e-1161125DB00371
DrugEthchlorvynol

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.27e-1091125DB00189
DrugFlumazenil

GABRA1 GABRA2 GABRA3 GABRA5

5.55e-1041124DB01205
DrugSecobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00418
DrugChlordiazepoxide

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00475
DrugMetharbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00463
DrugPentobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00312
DrugTalbutal

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00306
DrugClobazam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00349
DrugButalbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00241
DrugButabarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00237
DrugBromazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01558
DrugBarbituric acid derivative

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01496
DrugBarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01483
DrugHexobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01355
DrugAprobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01352
DrugAmobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01351
DrugHeptabarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01354
DrugButethal

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01353
DrugMethylphenobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00849
DrugOxazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00842
DrugPrimidone

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00794
DrugMidazolam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00683
DrugFlurazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB00690
DrugClonazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.50e-10101125DB01068
DrugThiopental

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00599
DrugAlprazolam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00404
DrugTemazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00231
DrugNitrazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB01595
DrugLorazepam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00186
DrugPhenobarbital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB01174
DrugTriazolam

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00897
DrugClorazepate

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.19e-09111125DB00628
DrugEszopiclone

GABRA1 GABRA2 GABRA3 GABRA5

2.76e-0951124DB00402
DrugZopiclone

GABRA1 GABRA2 GABRA3 GABRA5

2.76e-0951124DB01198
DrugLorazepam

GABRA1 GABRA2 GABRA3 GABRA4

2.76e-0951124ctd:D008140
Drug3-isothujone

SAGE1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.68e-09301126CID000011027
DrugFlunitrazepam

GABRA2 GABRA3 GABRA4 GABRA5

8.26e-0961124DB01544
Drugdihydroxyaflavinine

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.55e-08171125CID000156857
DrugQuazepam

GABRA1 GABRA2 GABRA3 GABRA5

1.92e-0871124DB01589
Druggamma-Aminobutyric Acid

PPARA SYN2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

2.27e-08621127ctd:D005680
Drugzaleplon

GBP7 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.54e-08391126CID000005719
DrugAdinazolam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB00546
DrugFludiazepam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB01567
DrugClotiazepam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB01559
DrugCinolazepam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB01594
DrugPrazepam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB01588
DrugEstazolam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB01215
DrugHalazepam

GABRA1 GABRA2 GABRA3 GABRA5

3.83e-0881124DB00801
Drugzolpidem

GBP7 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

6.51e-08431126CID000005732
DrugDiazepam

GABRA1 GABRA2 GABRA3 GABRA5

6.86e-0891124DB00829
Drugthymol

SAGE1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

9.88e-08461126CID000006989
Drugheptachlor epoxide

NCBP1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

9.88e-08461126CID000013930
Drugmethohexital

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

1.04e-07241125CID000009034
DrugAC1L1FKW

GABRA1 GABRA2 GABRA4 GABRA5

1.14e-07101124CID000003281
DrugZolpidem

GABRA1 GABRA2 GABRA3

1.16e-0731123DB00425
Drugisonipecotic acid

PPARA GABRA1 GABRA2 GABRA4 GABRA5

1.29e-07251125CID000003773
Drugfosazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000037114
DrugC19H18ClN3O

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000027452
Drugflutoprazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000003400
DrugArfendazam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000065803
Drugcamazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000037367
DrugBu-1014

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID015942721
DrugZapizolam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000068832
DrugReclazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID003052777
Drugiclazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000068777
Drugmenitrazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000189875
DrugSerin hydrazid

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000041637
Drugsulazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000017931
Drugelfazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000065445
Drugtriflubazam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000031157
Druguldazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000034274
Druggidazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000121919
Drugfletazepam

GABRA1 GABRA2 GABRA4 GABRA5

1.78e-07111124CID000036834
DrugSB-205384

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000197690
DrugU-93631

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000197626
Drughaloxazolam

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000003563
Drugdoxefazepam

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000038668
Drugpivoxazepam

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000068722
Drugrazobazam

GABRA1 GABRA2 GABRA4 GABRA5

2.66e-07121124CID000071228
Drugallylglycine

LARS2 GABRA1 GABRA2 GABRA4 GABRA5

3.40e-07301125CID000014044
Drugnerisopam

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000065875
Drugflutazolam

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000003398
Drug4-PIOL

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000125520
DrugAC1MVFYM

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID003707225
DrugRo 11-3128

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000093364
Drugcinolazepam

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID003033621
Drugalpha IMGBL

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000131516
Drugmetaclazepam

GABRA1 GABRA2 GABRA4 GABRA5

3.83e-07131124CID000071272
Drugflunitrazepam

LGMN GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.51e-07591126CID000003380
Drugetizolam

GABRA2 GABRA3 GABRA5

4.62e-0741123ctd:C044610
DrugAC1L1BIT

SCN2A GABRA1 EPHA4 GABRA2 GABRA4 GABRA5

4.99e-07601126CID000001457
Drug5 beta-pregnanediol

PPARA GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

4.99e-07601126CID000012547
Drugbeta-CCt

GABRA1 GABRA2 GABRA4 GABRA5

5.35e-07141124CID000124514
DrugMe-lex

GABRA1 GABRA2 GABRA4 GABRA5

5.35e-07141124CID000004177
Drugethyl loflazepate

GABRA1 GABRA2 GABRA4 GABRA5

5.35e-07141124CID000003299
DrugCGS 8216

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.60e-07331125CID000104916
DrugAC1L2FYN

GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

5.60e-07331125CID000071333
DrugXylometazoline hydrochloride [1218-35-5]; Down 200; 14.2uM; PC3; HT_HG-U133A

NSD2 NCBP1 GSAP TRMU BTN3A3 ZNF43 MACF1 OSMR CAPRIN1

6.02e-0719811292107_DN
DrugSR 95103

GABRA1 GABRA2 GABRA4 GABRA5

7.26e-07151124CID000125958
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN5A SCN9A

5.01e-06101043DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN5A SCN9A

5.01e-06101043DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN5A SCN9A

9.14e-06121043DOID:0060170 (implicated_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN2A SCN9A GABRA1

1.19e-05131043C0751122
DiseaseAutistic Disorder

ROBO1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5

3.33e-042611046C0004352
Diseaseaspartate aminotransferase measurement

DNAH2 ERVK13-1 RNF213 STAM CNNM1 NLRC5 ROBO1 PLAG1 LRBA ARHGAP45 IGSF21

3.51e-0490410411EFO_0004736
Diseasevaline measurement

GLS2 ADCYAP1R1 PPP2R3A

3.82e-04401043EFO_0009792
Diseasemean arterial pressure

RNF213 FIGN ROPN1L NFATC2 ROBO1 ZFHX3 NDUFAF6 LRBA

3.94e-044991048EFO_0006340
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN2A SCN9A

4.36e-0491042C3502809
Diseaseautistic disorder (is_implicated_in)

RAPGEF4 GABRA2 GABRA4

4.42e-04421043DOID:12849 (is_implicated_in)
Diseaseage of onset of depressive disorder, wellbeing measurement

ARHGAP45 ANKFN1

5.44e-04101042EFO_0007869, OBA_2040166
DiseaseEpilepsy

POLG ASXL3 SCN2A SCN9A

6.10e-041091044C0014544
Diseasesitting height ratio

ADAMTSL3 NFATC2 EPHB1

7.83e-04511043EFO_0007118
Diseaseautistic disorder (is_marker_for)

GABRA4 GABRA5

7.94e-04121042DOID:12849 (is_marker_for)
Diseaseneuroticism measurement, cognitive function measurement

FIGN ASXL3 SCN2A ZFHX3 PROC GABRA1 GABRA2 EPHB1

8.97e-045661048EFO_0007660, EFO_0008354
Diseaseasthma, Eczema, allergic rhinitis

GSAP TLR10 OTULIN NFATC2

9.02e-041211044EFO_0005854, HP_0000964, MONDO_0004979
Diseasesevere acute respiratory syndrome, COVID-19

FRMPD4 CRTC1 MICALL1 KSR1 SRGAP3 ZFHX3 EFCAB7

1.05e-034471047EFO_0000694, MONDO_0100096
DiseaseSchizophrenia

FZD3 PPARA LARS2 ADAMTSL3 ADCYAP1R1 SRGAP3 SYN2 GABRA1 GABRA4 GABRA5

1.13e-0388310410C0036341
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

CA12 BTN3A2 NLRC5 MACF1 LRBA

1.16e-032221045EFO_0008317, EFO_0020943
DiseaseTremor, Rubral

GABRA1 GABRA4

1.43e-03161042C0750940
DiseaseAtaxia, Appendicular

GABRA1 GABRA4

1.43e-03161042C0750937
DiseaseAtaxia, Motor

GABRA1 GABRA4

1.43e-03161042C0278161
DiseaseAtaxia, Sensory

GABRA1 GABRA4

1.43e-03161042C0240991
DiseaseAbnormal coordination

GABRA1 GABRA4

1.43e-03161042C0520966
DiseaseAtaxia, Truncal

GABRA1 GABRA4

1.43e-03161042C0427190
Diseasecortical thickness

GLS2 FZD3 CUL9 ADAMTSL3 MICALL1 SRGAP3 ROBO1 MACF1 OSMR ANKFN1 EPHA4

1.90e-03111310411EFO_0004840
Diseasecardiomyopathy (is_implicated_in)

MYH7 POLG

2.02e-03191042DOID:0050700 (is_implicated_in)
Diseaseexecutive function measurement

ADGRB3 CUL9 ST8SIA1 NLRC5 IGSF21 EPHB1

2.19e-033761046EFO_0009332
Diseaseleucine measurement

GLS2 LARS2 PPP2R3A

2.21e-03731043EFO_0009770
Diseaseheart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer

DNAH2 ZFHX3

2.24e-03201042EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
DiseaseHematochezia, response to radiation

ERICH1 PLPP4

2.24e-03201042GO_0009314, HP_0002573
DiseaseParoxysmal atrial fibrillation

MYH7 PPP2R3A SCN5A ZFHX3

2.29e-031561044C0235480
Diseasefamilial atrial fibrillation

MYH7 PPP2R3A SCN5A ZFHX3

2.29e-031561044C3468561
DiseasePersistent atrial fibrillation

MYH7 PPP2R3A SCN5A ZFHX3

2.29e-031561044C2585653
DiseaseAtrial Fibrillation

MYH7 PPP2R3A SCN5A ZFHX3

2.51e-031601044C0004238
Diseaseepilepsy (implicated_via_orthology)

SCN2A SCN5A SCN9A SYN2

2.69e-031631044DOID:1826 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN9A

2.71e-03221042DOID:2030 (implicated_via_orthology)
DiseaseMood Disorders

POLG CRTC1 GABRA1 GABRA5

3.00e-031681044C0525045
DiseaseEpilepsy, Cryptogenic

POLG ASXL3 SCN2A

3.08e-03821043C0086237
DiseaseAwakening Epilepsy

POLG ASXL3 SCN2A

3.08e-03821043C0751111
DiseaseAura

POLG ASXL3 SCN2A

3.08e-03821043C0236018
DiseaseAtaxia

GABRA1 GABRA4

3.50e-03251042C0004134

Protein segments in the cluster

PeptideGeneStartEntry
LMDKPHSAPCLMSLS

FAM223B

11

A6NKX1
HALEMFPEHCTMPPD

ERICH1

406

Q86X53
GNIIMMPDAQTIECH

ERVK13-1

216

Q9NX77
PCHLFPTMSAETMEL

BTN3A3

51

O00478
PCHLFPTMSAETMEL

BTN3A1

51

O00481
LHMPMSMNELSNPCL

ADGRB3

1256

O60242
MVPPLQCQMHPEEST

ETV3

326

P41162
HMEPAQKPCFTTDMV

ARHGEF4

21

Q9NR80
MDMPQLVCPPVHSES

CAPRIN1

401

Q14444
PAMINHSDMSNTIPD

ASPM

1231

Q8IZT6
HPTAPIICEFLTMMA

ATP8A1

471

Q9Y2Q0
SCVMMNDVLETLPHI

ASXL3

501

Q9C0F0
PVEAPHCSEYKMQMA

OSMR

936

Q99650
EMVKMVLSRPCHPDD

INTS3

856

Q68E01
AQSHRMDLMIDCQPP

INTS9

481

Q9NV88
PGVMDNPLVMHQLRC

MYH7

681

P12883
PMDCPAALHQLMLDC

EPHB1

846

P54762
CPMAEFALPRHSAVM

MAML1

6

Q92585
MDMDPFLHCVIPNFI

OGFOD1

56

Q8N543
HPMVAESPSCLVATM

NFATC2

711

Q13469
EPREMAAMCLGLAHS

NOP58

131

Q9Y2X3
HAMPATDLSAIMPSQ

FIGN

706

Q5HY92
PNIIDHFLCDMDPLM

OR11H4

181

Q8NGC9
AHNCRQSVMQEPHMP

ARHGAP45

321

Q92619
NCHVIAAPSMVAMFE

NCBP1

136

Q09161
EPPAALVRDKMMECH

TRMU

316

O75648
PMDCPIALHQLMLDC

EPHA4

846

P54764
KNSMPHTLDPMCDIA

FSIP2

806

Q5CZC0
TVQAECPMHLEDFPM

GABRA2

161

P47869
CPMHLEDFPMDAHSC

GABRA2

166

P47869
AFMQALMHAVDPEIP

GDF3

311

Q9NR23
ALYCTHMDDPSPREM

CA12

256

O43570
HENVVLFMGACMNPP

KSR1

666

Q8IVT5
HPDMMRLACADISIN

OR51I2

181

Q9H344
LPMDICMLHGVSQED

NDUFAF6

231

Q330K2
LMDKPHSAPCLMSLS

FAM223A

11

Q8IWN6
MLMFECHPQVCPAGE

NSD2

1036

O96028
ERCPHPVTLAGMLEM

POLG

416

P54098
VALMSEHPNSMIPAF

LRBA

701

P50851
LCMDSPSPMDPHMAE

CDC25B

111

P30305
DPNDMVSMSVPDCLS

MICALL1

81

Q8N3F8
MASEIHMPGPVCLTE

GBP7

1

Q8N8V2
TIHAECPMHLEDFPM

GABRA3

186

P34903
CPMHLEDFPMDVHAC

GABRA3

191

P34903
TVRAECPMHLEDFPM

GABRA1

161

P14867
CPMHLEDFPMDAHAC

GABRA1

166

P14867
ECPMRLVDFPMDGHA

GABRA4

171

P48169
AECPMQLEDFPMDAH

GABRA5

171

P31644
MMCLSPPLDKLGNSH

GLS2

431

Q9UI32
CIQAMIDPSMDPYPH

HUWE1

366

Q7Z6Z7
MGIEPLPFHDLLCQM

PPP2R3A

1011

Q06190
VMNSEMHCTGDPDLV

PLPP4

121

Q5VZY2
LPACLPAEAAMVHML

NLRC5

351

Q86WI3
NLKSICIPDVMPHMQ

MACF1

1921

Q9UPN3
CIPDVMPHMQLADSA

MACF1

1926

Q9UPN3
DHFPPIFMQAHECME

MAGEA13P

141

A6NCF6
ALLLLPMAPAMHSDC

ADCYAP1R1

11

P41586
PVVPHNECSEVMSNM

PROC

366

P04070
PRPEMQCPAEHEEDM

OTULIN

41

Q96BN8
FLTGNNEMIDMLPHC

GSAP

371

A4D1B5
NEMIDMLPHCPLQSL

GSAP

376

A4D1B5
SMLCLPMPSEHSLKQ

DNAH6

2231

Q9C0G6
CEVKHPALSMPMQAE

IGSF21

321

Q96ID5
PKSTMVCQHVMPLNE

EFCAB7

601

A8K855
HMLNDPDMVLADPAT

CRTC1

611

Q6UUV9
QTEGMCPRMTVPALH

FRMPD4

1281

Q14CM0
IQMHLDLENCMEEPP

ARFGEF3

1916

Q5TH69
PCHLFPTMSAETMEL

BTN3A2

51

P78410
PDMCISFEVEPMEHT

DRC7

651

Q8IY82
LCMAPASNIVPMMHG

MBNL3

311

Q9NUK0
PGVMHSSCPQEMAAV

LYPLA2

206

O95372
QTAALAMEPFHPMVN

FZD3

56

Q9NPG1
AMEPFHPMVNLDCSR

FZD3

61

Q9NPG1
PPCEAYALMAHAMEE

KHDRBS1

236

Q07666
GALDLLMHMLCNPEP

CUL9

166

Q8IWT3
NQDMCMKVPDDPEHL

CRYL1

281

Q9Y2S2
NLGSMACPIMEPLHL

CCDC168

3031

Q8NDH2
AEPMQLVCLMPTIHF

DNAH2

4351

Q9P225
NPSHAYMMDVCSPAD

SLC45A1

246

Q9Y2W3
NPPFVIHDMETLCMA

PPARA

236

Q07869
MLQVLQSCDHPGPDM

MAP3K15

346

Q6ZN16
TLALKPMNCPAHCLM

TARS2

401

Q9BW92
EVMDCSMPLIGEHQV

SYN2

386

Q92777
MHCVFMPNTQLCPAL

RAPGEF4

536

Q8WZA2
CLPMDQFAVHLMPHL

PPP4R1

856

Q8TF05
TMPICEEAGNMSHLE

TLR10

131

Q9BXR5
LCALMVMAAPLAPHV

LARS2

781

Q15031
ADLLPHMPHISECLM

SCHIP1

396

P0DPB3
LPSHMGCMSDVDADP

POU4F2

241

Q12837
INMDLPMVSGDRIHC

SCN5A

1836

Q14524
MLPVNGKMHSAVDCN

SCN9A

611

Q15858
CDPAHLFAMTKMNSP

ST8SIA1

86

Q92185
PHMGDMASQLCAQQP

SRGAP2B

346

P0DMP2
ASSMLPVMALAPQEH

NOP2

371

P46087
EHARAPEMPTNVCLM

ANKFN1

266

Q8N957
MNTCVPHPRGAFMLE

NCAPH2

181

Q6IBW4
TACHMDSSPQSPDME

CNNM1

791

Q9NRU3
LMEATLPGHRTMNPC

NEU3

76

Q9UQ49
LPLGMTCPIDMDTVH

PLAG1

311

Q6DJT9
MPLELICSDEHMQGS

RNF213

3891

Q63HN8
EHQMKDCPMPRNAAR

ZCCHC8

236

Q6NZY4
SHFVRPMQEVMGLPC

ZBTB5

476

O15062
HTVMDMCNQVFCPPL

SRGAP3

316

O43295
MPLPDTMFCAQQIHI

ROPN1L

1

Q96C74
ELINMTGHCMPPNAL

SAGE1

746

Q9NXZ1
PILPMNGKMHSAVDC

SCN2A

636

Q99250
HLEAMCHQMGPLIDE

STAM

331

Q92783
LQPMLQDCPEETGHM

ROBO1

1271

Q9Y6N7
CLHSESNMPLTMPAL

PLCB2

781

Q00722
MVAKPPVMCSHFTQD

ZNF43

71

P17038
HLQEPALCGPHMMFD

VEGFD

251

O43915
CQAQAPIAAVLLMHM

TBC1D10A

196

Q9BXI6
MATELQCPDSMPCHN

UPRT

1

Q96BW1
QDSPCIHPSEDSMDM

ZBTB26

161

Q9HCK0
HAMTQHSVQPMLRCP

ZFHX3

1241

Q15911
HSVQPMLRCPLCQDM

ZFHX3

1246

Q15911
NDSLCDMVHRPPAMS

ADAMTSL3

681

P82987
DMVHRPPAMSQACNT

ADAMTSL3

686

P82987
ALHIMAMLHPEVCEP

GEMIN4

986

P57678
IEACESGSMMNHLPD

LGMN

186

Q99538
MHCGPPDMVCETKIV

NAT8L

1

Q8N9F0