Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 ENG PSKH2 PRKX PRKY MAST3	6.85e-11	446	176	22	GO:0004674
GeneOntologyMolecularFunction	protein serine kinase activity	CDK20 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 PRKCH ATM MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	3.79e-09	363	176	18	GO:0106310
GeneOntologyMolecularFunction	protein kinase activity	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 ENG PSKH2 PRKX PRKY MAST3	1.68e-08	600	176	22	GO:0004672
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 GNPTAB OBSCN MAP3K20 HKDC1 TEP1 MAST2 STK16 TPK1 FICD TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 ENG PSKH2 PRKX PRKY MAST3	5.65e-08	938	176	27	GO:0016772
GeneOntologyMolecularFunction	kinase activity	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 HKDC1 MAST2 STK16 TPK1 TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 ENG PSKH2 PRKX PRKY MAST3	6.75e-08	764	176	24	GO:0016301
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 HKDC1 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 ENG PSKH2 PRKX PRKY MAST3	7.31e-08	709	176	23	GO:0016773
GeneOntologyMolecularFunction	sodium,bicarbonate:chloride antiporter activity	SLC4A8 SLC4A10	2.30e-04	3	176	2	GO:0140892
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX10 ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 STOX1 SOX8 ZNF441 STK16 LHX2 ZNF677 ZNF24 ZNF600 ZFHX4 NFATC1 FEZF1 NFATC4 ZNF425 ZNF770 ZNF418 USP3 ZNF791	4.58e-04	1459	176	26	GO:0000977
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9A9 SLC4A8 SLC9A2 SLC4A10	5.50e-04	43	176	4	GO:0140828
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	OGT RPS6KA2 MAP3K20 RICTOR STOX1 MAST2 TLK1 ARRB2 AGT UHMK1 CHEK2 PRKCH ATM MAPK1 PRKX MAST3	8.53e-09	307	175	16	GO:0018105
GeneOntologyBiologicalProcess	peptidyl-serine modification	OGT RPS6KA2 MAP3K20 RICTOR STOX1 MAST2 TLK1 ARRB2 AGT UHMK1 CHEK2 PRKCH ATM MAPK1 PRKX MAST3	1.47e-08	319	175	16	GO:0018209
GeneOntologyBiologicalProcess	protein autophosphorylation	GRK7 OBSCN MAP3K20 STK16 UHMK1 CHEK2 IRAK3 ATM EIF2AK1 PRKX	2.61e-05	228	175	10	GO:0046777
Domain	Ser/Thr_kinase_AS	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	1.47e-10	357	174	20	IPR008271
Domain	PROTEIN_KINASE_ST	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	1.88e-10	362	174	20	PS00108
Domain	Pkinase	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	3.01e-09	381	174	19	PF00069
Domain	S_TKc	CDK20 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	7.39e-09	359	174	18	SM00220
Domain	PROTEIN_KINASE_ATP	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	1.12e-08	459	174	20	PS00107
Domain	Prot_kinase_dom	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	3.21e-08	489	174	20	IPR000719
Domain	Kinase-like_dom	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH ATM MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	3.59e-08	542	174	21	IPR011009
Domain	PROTEIN_KINASE_DOM	CDK20 AMHR2 GRK7 PSKH1 RPS6KA2 OBSCN MAP3K20 MAST2 STK16 TLK1 UHMK1 CHEK2 IRAK3 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX PRKY MAST3	3.67e-08	493	174	20	PS50011
Domain	-	RAG1 ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	1.47e-06	679	174	21	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	RAG1 ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	2.08e-06	694	174	21	IPR013087
Domain	zf-C2H2	ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	7.49e-06	693	174	20	PF00096
Domain	AGC-kinase_C	GRK7 RPS6KA2 MAST2 PRKCH PRKX MAST3	1.32e-05	56	174	6	IPR000961
Domain	AGC_KINASE_CTER	GRK7 RPS6KA2 MAST2 PRKCH PRKX MAST3	1.32e-05	56	174	6	PS51285
Domain	S_TK_X	GRK7 RPS6KA2 MAST2 PRKCH PRKX MAST3	1.32e-05	56	174	6	SM00133
Domain	Znf_C2H2-like	RAG1 ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	1.70e-05	796	174	21	IPR015880
Domain	ZnF_C2H2	RAG1 ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	2.12e-05	808	174	21	SM00355
Domain	ZINC_FINGER_C2H2_2	ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	3.74e-05	775	174	20	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	3.87e-05	777	174	20	PS00028
Domain	zf-C2H2_6	ZNF384 ZNF573 ZNF560 ZSCAN31 ZNF677 ZNF24 ZNF600 FEZF1 ZNF425 ZNF770 ZNF418 ZNF791	3.98e-05	314	174	12	PF13912
Domain	Znf_C2H2	ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 ZFHX4 FEZF1 ZNF425 PRDM13 ZNF770 ZNF418 ZNF791 ZNF653	6.33e-05	805	174	20	IPR007087
Domain	IPT	NFATC1 NFATC4 PLXNA1 PLXNB3	1.08e-04	27	174	4	SM00429
Domain	TIG	NFATC1 NFATC4 PLXNA1 PLXNB3	1.88e-04	31	174	4	PF01833
Domain	IPT	NFATC1 NFATC4 PLXNA1 PLXNB3	2.13e-04	32	174	4	IPR002909
Domain	Sox_N	SOX10 SOX8	2.57e-04	3	174	2	IPR022151
Domain	Sox_N	SOX10 SOX8	2.57e-04	3	174	2	PF12444
Domain	DUF1908	MAST2 MAST3	5.11e-04	4	174	2	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST3	5.11e-04	4	174	2	IPR015022
Domain	MAST_pre-PK_dom	MAST2 MAST3	5.11e-04	4	174	2	IPR023142
Domain	-	MAST2 MAST3	5.11e-04	4	174	2	1.20.1480.20
Domain	KRAB	ZNF383 ZNF573 ZNF560 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF425 ZNF418 ZNF791	5.49e-04	358	174	11	PS50805
Domain	KRAB	ZNF383 ZNF573 ZNF560 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF425 ZNF418 ZNF791	5.49e-04	358	174	11	PF01352
Domain	Pkinase_C	RPS6KA2 MAST2 PRKCH MAST3	6.18e-04	42	174	4	PF00433
Domain	KRAB	ZNF383 ZNF573 ZNF560 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF425 ZNF418 ZNF791	7.04e-04	369	174	11	SM00349
Domain	KRAB	ZNF383 ZNF573 ZNF560 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF425 ZNF418 ZNF791	7.20e-04	370	174	11	IPR001909
Domain	Na/HCO3_transpt	SLC4A8 SLC4A10	8.47e-04	5	174	2	IPR003024
Domain	NFAT	NFATC1 NFATC4	8.47e-04	5	174	2	IPR008366
Domain	Protein_kinase_ATP_BS	CDK20 GRK7 PSKH1 RPS6KA2 OBSCN TLK1 PRKCH MAPK1 EIF2AK1 PSKH2 PRKX	8.76e-04	379	174	11	IPR017441
Domain	ANION_EXCHANGER_2	SLC4A8 SLC4A10	1.76e-03	7	174	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A8 SLC4A10	1.76e-03	7	174	2	PS00219
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RAG1 AMHR2 GRK7 PSKH1 RPS6KA2 MAST2 FBXO24 IRAK3 PRKCH EIF2AK1 PSKH2 PRKX PRKY	6.43e-08	372	176	13	22939624
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIF26A SYNE1 GNPTAB KCNH3 CEMIP MED23 PLXNB3	9.93e-07	103	176	7	10574462
Pubmed	Nf1 has an essential role in endothelial cells.	NF1 NFATC1 MAPK1	1.26e-06	5	176	3	12469121
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	NFATC1 NFATC4 PRKCH PLCD1 MAPK1	1.37e-06	38	176	5	12482669
Pubmed	Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.	CDK20 PPP5C MAPK1	7.00e-06	8	176	3	16954377
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LARGE2 FRAS1 GNPTAB NAGA EMC9 PGAP4 ZZEF1 CDKAL1 GGT7 FAT1 NF1 AGT ATM BMPER ENG PLOD2 CPVL PLXNA1 CA5A	1.21e-05	1201	176	19	35696571
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF384 FRAS1 KIF26A RPS6KA2 INPPL1 OBSCN TEP1 MAST2 ZZEF1 KCNH3 GGT7 TLK1 FAT1 MROH1 CHST15 NFATC1 CPVL PLXNA1	1.41e-05	1105	176	18	35748872
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	DMXL2 AMPD3 MYO9A NAGA DCDC2B MAST2 SIRT3 CDKAL1 NF1 PPP5C HPF1 EHD1 PXYLP1 MAPK1 MED23 USP3 ZNF791 ACTL10 PLXNB3	1.92e-05	1242	176	19	30973865
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TTC21A OBSCN DNAH2 STOX1 ITGAE ZZEF1 FRY RNF123 THYN1 PITPNM3 PRDM13 ATM PLXNB3 CA5A	2.53e-05	736	176	14	29676528
Pubmed	Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells.	CHEK2 ATM	2.55e-05	2	176	2	33607997
Pubmed	Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.	CHEK2 ATM	2.55e-05	2	176	2	16794575
Pubmed	Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome.	RAB3GAP1 RAB3GAP2	2.55e-05	2	176	2	15696165
Pubmed	Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma.	RAG1 ATM	2.55e-05	2	176	2	10346813
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	2.55e-05	2	176	2	9414316
Pubmed	Transcription Factors Sox8 and Sox10 Contribute with Different Importance to the Maintenance of Mature Oligodendrocytes.	SOX10 SOX8	2.55e-05	2	176	2	39201442
Pubmed	A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.	CHEK2 ATM	2.55e-05	2	176	2	20599567
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	2.55e-05	2	176	2	15879576
Pubmed	Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.	CHEK2 ATM	2.55e-05	2	176	2	15361830
Pubmed	Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.	CHEK2 ATM	2.55e-05	2	176	2	25425972
Pubmed	ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire.	RAG1 ATM	2.55e-05	2	176	2	23626787
Pubmed	Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption.	NFATC1 MAPK1	2.55e-05	2	176	2	30078210
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	2.55e-05	2	176	2	9302280
Pubmed	Hypoxia exosome derived CEACAM5 promotes tumor-associated macrophages M2 polarization to accelerate pancreatic neuroendocrine tumors metastasis via MMP9.	CEACAM5 MMP9	2.55e-05	2	176	2	38923643
Pubmed	NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.	NF1 ATM	2.55e-05	2	176	2	31664505
Pubmed	p38 MAP kinase regulates rapid matrix metalloproteinase-9 release from eosinophils.	MAPK1 MMP9	2.55e-05	2	176	2	14766231
Pubmed	Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamics.	CHEK2 ATM	2.55e-05	2	176	2	31845505
Pubmed	Breast cancer screening implications of risk modeling among female relatives of ATM and CHEK2 carriers.	CHEK2 ATM	2.55e-05	2	176	2	31967672
Pubmed	Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.	CHEK2 ATM	2.55e-05	2	176	2	19881958
Pubmed	Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.	CHEK2 ATM	2.55e-05	2	176	2	32220941
Pubmed	Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein.	RAB3GAP1 RAB3GAP2	2.55e-05	2	176	2	9733780
Pubmed	Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.	ARRB2 MAPK1	2.55e-05	2	176	2	15699045
Pubmed	Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice.	NF1 MAPK1	2.55e-05	2	176	2	28673309
Pubmed	Increases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells.	CHEK2 ATM	2.55e-05	2	176	2	22808196
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	2.55e-05	2	176	2	10729225
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	2.55e-05	2	176	2	7633447
Pubmed	Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.	CHEK2 ATM	2.55e-05	2	176	2	12857758
Pubmed	Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression.	CHEK2 ATM	2.55e-05	2	176	2	25872745
Pubmed	K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.	SLC4A8 SLC4A10	2.55e-05	2	176	2	38674160
Pubmed	Clinicopathologic Profile of Breast Cancer in Germline ATM and CHEK2 Mutation Carriers.	CHEK2 ATM	2.55e-05	2	176	2	33919281
Pubmed	Ataxia-telangiectasia group D complementing gene (ATDC) upregulates matrix metalloproteinase 9 (MMP-9) to promote lung cancer cell invasion by activating ERK and JNK pathways.	ATM MMP9	2.55e-05	2	176	2	23681803
Pubmed	Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model.	CHEK2 ATM	2.55e-05	2	176	2	34322652
Pubmed	Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.	CHEK2 ATM	2.55e-05	2	176	2	9836640
Pubmed	Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.	CHEK2 ATM	2.55e-05	2	176	2	22770119
Pubmed	SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma.	SIRT3 ATM	2.55e-05	2	176	2	33273545
Pubmed	NFATc1 induction by an intronic enhancer restricts NKT γδ cell formation.	RAG1 NFATC1	2.55e-05	2	176	2	36926655
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	2.55e-05	2	176	2	21684272
Pubmed	Ethanol metabolism activates cell cycle checkpoint kinase, Chk2.	CHEK2 ATM	2.55e-05	2	176	2	21924579
Pubmed	Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes.	MAPK1 MMP9	2.55e-05	2	176	2	23468369
Pubmed	Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.	LHX2 PLOD2	2.55e-05	2	176	2	34718219
Pubmed	Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor.	SOX10 SOX8	2.55e-05	2	176	2	16822525
Pubmed	Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.	CHEK2 ATM	2.55e-05	2	176	2	19798429
Pubmed	SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects.	SOX10 RAG1	2.55e-05	2	176	2	34879275
Pubmed	Distinct roles of NFATc1 and NFATc4 in human primary myoblast differentiation and in the maintenance of reserve cells.	NFATC1 NFATC4	2.55e-05	2	176	2	28760926
Pubmed	The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.	CHEK2 ATM	2.55e-05	2	176	2	18667510
Pubmed	A human MAP kinase interactome.	USP53 KIF26A MYO9A SYNE1 TLK1 ZNF600 ARRB2 PRKCH ANKRD24 MAPK1 ZNF418	4.10e-05	486	176	11	20936779
Pubmed	Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA.	SOX10 NF1 MAPK1	6.80e-05	16	176	3	28637693
Pubmed	Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.	RAG1 NFATC1	7.61e-05	3	176	2	32986812
Pubmed	Clinicopathological Features and Outcomes in Individuals with Breast Cancer and ATM, CHEK2, or PALB2 Mutations.	CHEK2 ATM	7.61e-05	3	176	2	32996020
Pubmed	Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways.	MAPK1 MMP9	7.61e-05	3	176	2	20359813
Pubmed	Variation in telangiectasia predisposing genes is associated with overall radiation toxicity.	ATM ENG	7.61e-05	3	176	2	22677372
Pubmed	Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells.	RICTOR PRKCH	7.61e-05	3	176	2	30154443
Pubmed	TP53-binding protein variants and breast cancer risk: a case-control study.	CHEK2 ATM	7.61e-05	3	176	2	15987456
Pubmed	Identification of ITGA4/ITGB7 and ITGAE/ITGB7 expressing subsets of decidual dendritic-like cells within distinct microdomains of the pregnant mouse uterus.	ITGA4 ITGAE	7.61e-05	3	176	2	18562709
Pubmed	An ATM-Chk2-INCENP pathway activates the abscission checkpoint.	CHEK2 ATM	7.61e-05	3	176	2	33355621
Pubmed	Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells.	NFATC1 MAPK1	7.61e-05	3	176	2	12594266
Pubmed	Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.	CHEK2 ATM	7.61e-05	3	176	2	18802408
Pubmed	The RAB GTPase RAB18 modulates macroautophagy and proteostasis.	RAB3GAP1 RAB3GAP2	7.61e-05	3	176	2	28342870
Pubmed	T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.	RAG1 RICTOR	7.61e-05	3	176	2	24315998
Pubmed	The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.	ARRB2 ENG	7.61e-05	3	176	2	17540773
Pubmed	Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.	RPS6KA2 MAPK1	7.61e-05	3	176	2	12016217
Pubmed	Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway.	NFATC1 MAPK1	7.61e-05	3	176	2	10748182
Pubmed	Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries.	AGT MAPK1	7.61e-05	3	176	2	19948989
Pubmed	Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro.	NF1 ENG	7.61e-05	3	176	2	29643433
Pubmed	Blockade of αEβ7 integrin suppresses accumulation of CD8+ and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.	ITGA4 ITGAE	7.61e-05	3	176	2	27543429
Pubmed	Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.	CHEK2 ATM	7.61e-05	3	176	2	16574953
Pubmed	Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.	PPP5C ATM	7.61e-05	3	176	2	17376776
Pubmed	The diagnostic value of the measurement of matrix metalloproteinase 9 (MMP-9), squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) in the sera of esophageal cancer patients.	CEACAM5 MMP9	7.61e-05	3	176	2	18155162
Pubmed	Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.	CHEK2 ATM	7.61e-05	3	176	2	21156285
Pubmed	The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.	MAP3K20 CHEK2	7.61e-05	3	176	2	15342622
Pubmed	Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.	CHEK2 ATM	7.61e-05	3	176	2	17132159
Pubmed	Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer.	CEACAM5 CEACAM3	7.61e-05	3	176	2	20373053
Pubmed	Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer.	CHEK2 ATM	7.61e-05	3	176	2	22420423
Pubmed	A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve†.	CHEK2 ATM	7.61e-05	3	176	2	31074776
Pubmed	Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.	ARRB2 MAPK1	7.61e-05	3	176	2	26324936
Pubmed	DNA damage response-related proteins in gastric cancer: ATM, Chk2 and p53 expression and their prognostic value.	CHEK2 ATM	7.61e-05	3	176	2	23969480
Pubmed	The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	CHEK2 ATM	7.61e-05	3	176	2	23333640
Pubmed	RAB3GAP1, RAB3GAP2 and RAB18: disease genes in Micro and Martsolf syndromes.	RAB3GAP1 RAB3GAP2	7.61e-05	3	176	2	23176487
Pubmed	The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism.	SOX10 SOX8	7.61e-05	3	176	2	31194875
Pubmed	Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.	CHEK2 ATM	7.61e-05	3	176	2	12097646
Pubmed	Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.	RAG1 ATM	7.61e-05	3	176	2	19820166
Pubmed	Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.	NF1 MAPK1	7.61e-05	3	176	2	23221339
Pubmed	ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.	CHEK2 ATM	7.61e-05	3	176	2	32187724
Pubmed	Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.	CHEK2 ATM	7.61e-05	3	176	2	26025911
Pubmed	Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk.	CHEK2 ATM	7.61e-05	3	176	2	17164260
Pubmed	Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.	SOX10 SOX8	7.61e-05	3	176	2	18512230
Pubmed	O-GlcNAc modification affects the ATM-mediated DNA damage response.	OGT ATM	7.61e-05	3	176	2	22759405
Pubmed	Factors that differentiate cancer risk management decisions among females with pathogenic/likely pathogenic variants in PALB2, CHEK2, and ATM.	CHEK2 ATM	7.61e-05	3	176	2	37515473
Pubmed	DNA damage signaling is activated during cancer progression in human colorectal carcinoma.	CHEK2 ATM	7.61e-05	3	176	2	20023412
Pubmed	Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.	CHEK2 ATM	7.61e-05	3	176	2	19996108
Pubmed	Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency.	AMHR2 MMP9	7.61e-05	3	176	2	17404209
Cytoband	2q24.2	MAP3K20 SLC4A10 PSMD14	8.08e-05	22	176	3	2q24.2
Cytoband	12q13	AMHR2 LIMA1 KCNH3 MYG1	1.66e-04	71	176	4	12q13
Cytoband	3q24	SLC9A9 GRK7 PLOD2	2.30e-04	31	176	3	3q24
Cytoband	17p13	ITGAE ARRB2 PITPNM3	3.04e-04	34	176	3	17p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF384 ZNF383 ZNF573 ZNF560 ZSCAN31 ZNF337 ZNF460 ZNF213 ZNF441 ZNF677 ZNF24 ZNF600 FEZF1 ZNF425 ZNF770 ZNF418 ZNF791 ZNF653	1.35e-06	718	121	18	28
GeneFamily	Nuclear factors of activated T-cells	NFATC1 NFATC4	4.38e-04	5	121	2	665
GeneFamily	Plexins	PLXNA1 PLXNB3	1.55e-03	9	121	2	683
ToppCell	tumor_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	FRAS1 CEACAM5 TTC21A PYROXD2 OBSCN ADGRB3 SLC9A2 OR52K2 CPVL	7.12e-09	146	176	9	8b2d104fdb0fdb09410450c6c651e1edb00cae44
ToppCell	Immune-monocyte\|World / Lineage, Cell type, age group and donor	SLC9A9 DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	9.94e-08	198	176	9	d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC9A9 DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	1.04e-07	199	176	9	ac866ae110967c5867ff4601939b79861d43df54
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A SYNE1 SLC22A23 CHST9 CDKAL1 TPK1 FAT1 CPVL	5.20e-07	176	176	8	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 CEACAM5 MYO9A CYP4B1 SLC22A23 GSAP PLOD2 FGD3	5.42e-07	177	176	8	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	USP53 DNAH2 RICTOR BRD9 CFAP74 PRKCH ATM	6.03e-07	123	176	7	511b7c20a4a85e49980936d52af7dbca19bb848e
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	AKAP6 TTC21A DNAH2 DCDC2B FAM227A CFAP206 CFAP74 ANKFN1	7.58e-07	185	176	8	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	LAM-Epithelial-AirwayEpi\|LAM / Condition, Lineage and Cell class	CYP4B1 DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206 CFAP74	1.00e-06	192	176	8	7404fc65be3b7bd09447725b43fa31819004dfee
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	AKAP6 CYP4B1 TTC21A DNAH2 CHST9 STOX1 FAM227A CFAP74	1.04e-06	193	176	8	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	SYNE1 GNPTAB GSAP ITGA4 PRKCH ATM MAPK1 PRKX	1.08e-06	194	176	8	7773501e076d470158dbc1d7f10c67152b326eb7
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	ZNF384 OGT SYNE1 TTC8 CROT ATM MED23	1.13e-06	135	176	7	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	Adult-Immune-monocyte\|Adult / Lineage, Cell type, age group and donor	SLC9A9 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	1.17e-06	196	176	8	3ef193c5180de3137daf886492e74fc574bc9767
ToppCell	Adult-Immune-monocyte-D122\|Adult / Lineage, Cell type, age group and donor	SLC9A9 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	1.17e-06	196	176	8	16b0acb6157534938ca83d4e909471e33a7d3c52
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC9A9 DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.17e-06	196	176	8	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	DMXL2 CEACAM3 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	1.22e-06	197	176	8	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 ITGA4 CHST15 IRAK3 PRKCH CPVL HCLS1 FGD3	1.22e-06	197	176	8	c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	AMPD3 SYNE1 CEACAM3 EHD1 IRAK3 ZNF770 MMP9 FGD3	1.31e-06	199	176	8	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1 FGD3	1.36e-06	200	176	8	fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FRAS1 MYO9A CYP4B1 SLC22A23 GSAP PLOD2 PLXNA1 FGD3	1.36e-06	200	176	8	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DMXL2 CEACAM3 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.36e-06	200	176	8	fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 CDK20 TTC21A STOX1 ANO7 ANKFN1 CA5A	3.96e-06	163	176	7	360cd65decda24853124f33a174f5224d7f3ce23
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 CDK20 TTC21A STOX1 ANO7 ANKFN1 CA5A	3.96e-06	163	176	7	b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	IL11RA KIF26A PGAP4 KCNH3 KL PTPRN ENG	6.81e-06	177	176	7	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AKAP6 SLC4A8 TTC21A DNAH2 KCNH3 FAM227A CFAP206	7.07e-06	178	176	7	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR182 PYROXD2 CDKAL1 CEMIP CHST15 CFAP206 MMP9	8.17e-06	182	176	7	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RPS6KA2 GPR182 CEMIP GPR146 CHST15 ENG	1.01e-05	188	176	7	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RPS6KA2 GPR182 CEMIP GPR146 CHST15 ENG	1.01e-05	188	176	7	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RPS6KA2 GPR182 CEMIP GPR146 CHST15 ENG	1.01e-05	188	176	7	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	(7)_Epithelial-F_(Ciliated)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206 CFAP74	1.01e-05	188	176	7	9a8b9f745eed9f129b6c582f48fbbaaacbebb4b3
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.04e-05	189	176	7	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	Ciliated\|World / shred by cell class for parenchyma	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206 CFAP74	1.04e-05	189	176	7	711181ca3b9102fb155168b646b0a9b09ff215b2
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PYROXD2 NAGA TEP1 ATM ENG HCLS1 CA5A	1.08e-05	190	176	7	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Healthy_Control-Epithelial-Epithelial-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206	1.12e-05	191	176	7	28caedb2e448e0c7f494100d714fa7cdcf150691
ToppCell	Healthy_Control-Epithelial-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206	1.12e-05	191	176	7	15b9386b26caaa7d15f704c4a18881e1ce918a21
ToppCell	Healthy_Control-Epithelial\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	CYP4B1 DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206	1.12e-05	191	176	7	fdcdadbfc9ccae175abe4de8c7428ac4f6a67fde
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL11RA LIMA1 COL6A6 ITIH5 ZFHX4 BMPER PLOD2	1.16e-05	192	176	7	11088878043a6ff95ba1970361256a82e434b80a
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	AKAP6 SYNE1 DNAH2 FAM227A CFAP206 CFAP74 ANKFN1	1.20e-05	193	176	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK\|bone_marrow / Manually curated celltypes from each tissue	SYNE1 GNPTAB GSAP ITGA4 PRKCH MAPK1 PRKX	1.20e-05	193	176	7	e790ab76c12f74a13936c231076f1e397283efb3
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH2 DCDC2B STOX1 FAM227A CFAP206 CFAP74 ANKFN1	1.24e-05	194	176	7	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	SLC9A9 DMXL2 GSAP ARRB2 IRAK3 CPVL HCLS1	1.24e-05	194	176	7	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 GNPTAB GSAP ITGA4 PRKCH ATM PRKY	1.24e-05	194	176	7	ae5357e2a276473cde1fc8c43acaf9f69da35fd7
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SYNE1 GNPTAB GSAP ITGA4 PRKCH ATM PRKY	1.24e-05	194	176	7	3a0b8b5d0354c43da57bb951cd8ba878363c3de5
ToppCell	3'-Child04-06-SmallIntestine-Neuronal\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL11RA SOX10 ADGRB3 CHST9 ZFHX4 CAB39L TMEM255A	1.28e-05	195	176	7	8d286622f86c844d1b06a106ee4a3f813eba05bb
ToppCell	3'-Child04-06-SmallIntestine-Neuronal-Glial_mature\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL11RA SOX10 ADGRB3 CHST9 ZFHX4 CAB39L TMEM255A	1.28e-05	195	176	7	4193e58788e90c3d1049ef5cf9800a8c4d8ac354
ToppCell	Adult-Immune-monocyte-D231\|Adult / Lineage, Cell type, age group and donor	SLC9A9 CEACAM3 ITGA4 ARRB2 CHST15 CPVL FGD3	1.28e-05	195	176	7	ea24da6fea1487acb1e56c28c0649858cc0a12bd
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CEACAM3 ADGRB3 F5 EHD1 IRAK3 MMP9 ANKRD7	1.28e-05	195	176	7	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Children_(3_yrs)-Immune-monocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC9A9 DMXL2 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.28e-05	195	176	7	81a28289eda1a8a1a31b7357106f64ac5000e172
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CEACAM3 ADGRB3 F5 EHD1 IRAK3 MMP9 ANKRD7	1.28e-05	195	176	7	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	USP53 FRAS1 COL6A6 ADGRB3 ITIH5 CEMIP BMPER	1.28e-05	195	176	7	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SYNE1 TTC21A DNAH2 DCDC2B STOX1 FAM227A CFAP74	1.28e-05	195	176	7	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	3'-Child04-06-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL11RA SOX10 ADGRB3 CHST9 ZFHX4 CAB39L TMEM255A	1.28e-05	195	176	7	359b9d791e26844675c3c60cf69d8ab69c2cf400
ToppCell	Bronchial-NucSeq-Stromal-Schwann\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX10 KIF26A ADGRB3 SOX8 ZFHX4 CAB39L PLXNB3	1.32e-05	196	176	7	a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 CEACAM3 NAGA ARRB2 CHST15 IRAK3 CPVL	1.32e-05	196	176	7	51fc8bb9a806f8fbf78d5d80d535f1068a9770c2
ToppCell	COVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 ITGA4 ARRB2 IRAK3 CPVL HCLS1 FGD3	1.37e-05	197	176	7	e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCell	COVID-19-kidney-Macrophages\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC9A9 DMXL2 AMPD3 GSAP IRAK3 MMP9 HCLS1	1.37e-05	197	176	7	3912301018d0863144dcfac8d1fa8adc081748d7
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX10 KIF26A ADGRB3 SOX8 ZFHX4 CAB39L PLXNB3	1.37e-05	197	176	7	4a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CDK20 TTC21A STOX1 FBXO24 FAM227A CFAP206 CFAP74	1.37e-05	197	176	7	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 ITGA4 ARRB2 CHST15 IRAK3 HCLS1 FGD3	1.41e-05	198	176	7	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-gd_T\|ICU-SEP / Disease, condition lineage and cell class	LIMA1 SLC4A8 SYNE1 STOX1 PRKCH ANKRD24 TMEM255A	1.41e-05	198	176	7	b40899f8f5f32420fb4574069dd7afd9e7e70d91
ToppCell	distal-Epithelial-Ciliated-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206 CFAP74	1.46e-05	199	176	7	2de1fe124737a6cca4b3805ab3056f9d9d7c16c7
ToppCell	Children_(3_yrs)-Immune-monocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC9A9 DMXL2 ITGA4 ARRB2 CHST15 IRAK3 HCLS1	1.51e-05	200	176	7	881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP74 ANKFN1	1.51e-05	200	176	7	85c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP206 CFAP74	1.51e-05	200	176	7	5abd6d81e1cc354484ae693fcd708d78926e75b5
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP74 ANKFN1	1.51e-05	200	176	7	12bc7d95c4166d12487081a76d210b7abe5991b0
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TTC21A DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP74	1.51e-05	200	176	7	ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Ciliated\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TTC21A DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP74	1.51e-05	200	176	7	a521cf837cadf280505ff9d7e641a205af7d6513
ToppCell	Biopsy_Control_(H.)-Immune-Monocytes\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.51e-05	200	176	7	c58a5dc0a0d74a21ca15ee8b7a0197de32afa045
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC21A DNAH2 DCDC2B CHST9 STOX1 FAM227A CFAP74	1.51e-05	200	176	7	918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCell	Biopsy_Other_PF-Immune-Monocytes\|Biopsy_Other_PF / Sample group, Lineage and Cell type	DMXL2 ITGA4 ARRB2 CHST15 IRAK3 CPVL HCLS1	1.51e-05	200	176	7	83bca55d48aae8885deb83e15b2684910e4c3358
ToppCell	facs-Lung-EPCAM-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX10 RAG1 CYP4B1 STOX1 FADS1 HPF1	3.68e-05	156	176	6	bb64bf520cb74897a01c64924a85a1550df2b801
ToppCell	18-Distal-Epithelial-Basal_cell\|Distal / Age, Tissue, Lineage and Cell class	SLC22A23 PEX12 CHST9 PCDH20 CEMIP KL	3.95e-05	158	176	6	183f445967e09e871c93d8e94781ed9fec894169
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC4A10 PITPNM3 MMP9 PLOD2 CPVL IL27	4.09e-05	159	176	6	210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCell	ICU-SEP-Lymphocyte-T_NK-gdT\|ICU-SEP / Disease, Lineage and Cell Type	LIMA1 SLC4A8 STOX1 PRKCH ANKRD24 TMEM255A	4.24e-05	160	176	6	0a14b1fed54a09c0caf263662b5bd426466c7189
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DNHD1 ZNF383 AMPD3 ZSCAN31 DCDC2B CFAP74	4.24e-05	160	176	6	6de505bfe1fbbe984718740a9cf43d0e02ff452e
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	DNHD1 ZSCAN31 DCDC2B CHST9 FAM227A CFAP74	5.03e-05	165	176	6	731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF383 ZSCAN31 INPPL1 ITIH5 SLC9A2 CHST15	5.03e-05	165	176	6	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AKAP6 ZNF384 UHMK1 FAM227A ZNF770 ENG	5.38e-05	167	176	6	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ZNF383 ZSCAN31 INPPL1 ITIH5 SLC9A2 CHST15	5.56e-05	168	176	6	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 USP53 SOX10 CHST9 SOX8 TMEM255A	5.56e-05	168	176	6	af82e07d1eec51fc6530155f37addbce6221885d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TTC21A DNAH2 DCDC2B FAM227A CFAP74 ANKFN1	5.75e-05	169	176	6	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 SLC4A8 RPS6KA2 ADGRB3 PCDH20 AGT	5.94e-05	170	176	6	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9A9 DMXL2 RPS6KA2 ADGRB3 NFATC1 AGT	6.97e-05	175	176	6	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	droplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A8 CDKAL1 FICD ZNF24 UBA7 ZNF653	7.19e-05	176	176	6	24b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC4A8 CDKAL1 FICD ZNF24 UBA7 ZNF653	7.42e-05	177	176	6	f360f7099570d248531897b96e0de282e58f59e9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A SYNE1 SLC22A23 CDKAL1 TPK1 CPVL	7.42e-05	177	176	6	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHST9 SEC24D KL CHST15 BMPER PRKY	7.42e-05	177	176	6	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM3 NAGA ITGA4 CPVL HCLS1 CA5A	7.66e-05	178	176	6	aa9f68a66e292f331faef881bbd0d028f0f2b0c5
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 COL6A6 RPS6KA2 SLC2A2 SEC24D PITPNM3	7.66e-05	178	176	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	LPS_only-Myeloid-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	7.90e-05	179	176	6	d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCell	LPS_only-Myeloid-Neutrophils-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	7.90e-05	179	176	6	d034651a5a355a58f5e15db627869f4feebdfe35
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AKAP6 SOX10 PCDH20 GGT7 ZFHX4 PLXNB3	8.14e-05	180	176	6	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	LPS-IL1RA-Myeloid-Neutrophils-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	8.14e-05	180	176	6	c0c07937839652e01df10cc1e70aa005800ea6f6
ToppCell	LPS-IL1RA-Myeloid-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	8.14e-05	180	176	6	079c199425dd3c220f03c6dca1823946f07580a1
ToppCell	Thalamus-Macroglia\|Thalamus / BrainAtlas - Mouse McCarroll V32	SOX10 INPPL1 SOX8 ZNF24 FADS1 PLXNB3	8.39e-05	181	176	6	4f62b63854a4e9fea6e839f0340e78392c66fb0e
ToppCell	droplet-Heart-nan-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP4B1 RPS6KA2 GPR182 CHEK2 PRKCH ENG	8.39e-05	181	176	6	859c40889ede2cbf374c4d2efbb72dc3bc6441f5
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	DNAH2 DCDC2B CHST9 FAM227A CFAP74 ANKFN1	8.65e-05	182	176	6	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	DNAH2 CHST9 FAM227A CFAP206 CFAP74 ANKFN1	8.65e-05	182	176	6	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	8.65e-05	182	176	6	243c783675df495ea4112dbf710712c44ea6b4f1
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DMXL2 GSAP EHD1 IRAK3 MMP9 HCLS1	8.65e-05	182	176	6	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AKAP6 SOX10 PCDH20 CEMIP ZFHX4 PLXNB3	8.65e-05	182	176	6	a1c0e4090a9e7aa4941a40c817d178de144888b6
Disease	Martsolf syndrome	RAB3GAP1 RAB3GAP2	3.15e-05	2	166	2	C0796037
Disease	Warburg micro syndrome (implicated_via_orthology)	RAB3GAP1 RAB3GAP2	3.15e-05	2	166	2	DOID:0060237 (implicated_via_orthology)
Disease	renal fibrosis (biomarker_via_orthology)	MAPK1 MMP9 ENG	3.71e-05	12	166	3	DOID:0050855 (biomarker_via_orthology)
Disease	prediabetes syndrome (biomarker_via_orthology)	SLC4A8 SIRT3 AGT	3.71e-05	12	166	3	DOID:11716 (biomarker_via_orthology)
Disease	Squamous cell carcinoma	MRPL13 SIRT3 UBA7 ATM MAPK1 MMP9	7.48e-05	124	166	6	C0007137
Disease	Warburg Sjo Fledelius syndrome	RAB3GAP1 RAB3GAP2	1.87e-04	4	166	2	C1838625
Disease	Warburg micro syndrome	RAB3GAP1 RAB3GAP2	1.87e-04	4	166	2	cv:C5442005
Disease	STROKE, ISCHEMIC	F5 PRKCH	3.11e-04	5	166	2	601367
Disease	Ischemic stroke	F5 PRKCH	3.11e-04	5	166	2	cv:C0948008
Disease	hypertension (biomarker_via_orthology)	KL FADS1 ARRB2 AGT PLCD1 MMP9 ENG	3.13e-04	227	166	7	DOID:10763 (biomarker_via_orthology)
Disease	congestive heart failure (biomarker_via_orthology)	OGT SIRT3 AGT MMP9 ENG	3.55e-04	107	166	5	DOID:6000 (biomarker_via_orthology)
Disease	pre-eclampsia (is_implicated_in)	STOX1 F5 AGT	3.67e-04	25	166	3	DOID:10591 (is_implicated_in)
Disease	portal hypertension (is_marker_for)	F5 ARRB2	4.65e-04	6	166	2	DOID:10762 (is_marker_for)
Disease	level of Phosphatidylcholine (18:2_0:0) in blood serum	FADS1 CAB39L	4.65e-04	6	166	2	OBA_2045105
Disease	Neointima Formation	AGT MMP9	4.65e-04	6	166	2	C2936381
Disease	Neointima	AGT MMP9	4.65e-04	6	166	2	C2936380
Disease	lung small cell carcinoma (is_implicated_in)	RICTOR FAT1 ATM	5.17e-04	28	166	3	DOID:5409 (is_implicated_in)
Disease	pulmonary hypertension (is_implicated_in)	F5 MAPK1 MMP9	6.35e-04	30	166	3	DOID:6432 (is_implicated_in)
Disease	response to platinum based chemotherapy, methylcobalamin deficiency type cblE, cytotoxicity measurement	SLC9A9 PCDH20	6.49e-04	7	166	2	EFO_0004647, EFO_0006952, MONDO_0009354
Disease	arteriovenous malformations of the brain (implicated_via_orthology)	PITPNM3 ENG	6.49e-04	7	166	2	DOID:0060688 (implicated_via_orthology)
Disease	10-undecenoate 11:1n1 measurement	CYP4B1 MAST2	6.49e-04	7	166	2	EFO_0021099
Disease	Aortic Aneurysm	AGT MMP9	6.49e-04	7	166	2	C0003486
Disease	Alzheimer's disease (is_marker_for)	STOX1 SIRT3 AGT PLCD1 ATM MAPK1 MMP9	6.57e-04	257	166	7	DOID:10652 (is_marker_for)
Disease	esophagus squamous cell carcinoma (is_marker_for)	RICTOR FAT1 ATM MMP9	8.18e-04	74	166	4	DOID:3748 (is_marker_for)
Disease	Bone neoplasms	MMP9 PLOD2	8.61e-04	8	166	2	C0005967
Disease	Malignant Bone Neoplasm	MMP9 PLOD2	8.61e-04	8	166	2	C0279530
Disease	circulating alpha-Klotho measurement	CHST9 KL	8.61e-04	8	166	2	EFO_0020102
Disease	female breast cancer (is_implicated_in)	CHEK2 ATM	8.61e-04	8	166	2	DOID:0050671 (is_implicated_in)
Disease	thoracic aortic calcification measurement	COL6A6 CDKAL1	1.10e-03	9	166	2	EFO_0010273
Disease	macrovascular complications of diabetes	RPS6KA2 F5	1.37e-03	10	166	2	EFO_0010977
Disease	Aortic Aneurysm, Abdominal	AGT MMP9	1.37e-03	10	166	2	C0162871
Disease	pleural tuberculosis (is_marker_for)	MMP9 IL27	1.37e-03	10	166	2	DOID:106 (is_marker_for)
Disease	skin microbiome measurement	ADGRB3 LHX2 KL	1.38e-03	39	166	3	EFO_0801228
Disease	creatinine measurement	GRK7 OBSCN MRPL13 MAST2 GGT7 CEMIP FRY RNF123 SLC9A2 FADS1 NFATC1 USP32 MED23 FBXL20	1.55e-03	995	166	14	EFO_0004518
Disease	congestive heart failure (implicated_via_orthology)	PLCD1 MMP9 ENG	1.59e-03	41	166	3	DOID:6000 (implicated_via_orthology)
Disease	HbA1c measurement	AMPD3 HKDC1 GSAP SLC2A2 SIRT3 CDKAL1 RNF123 KL FADS1 PXYLP1 CPVL	1.60e-03	675	166	11	EFO_0004541
Disease	breast cancer (is_implicated_in)	F5 AGT CHEK2 ATM ENG	1.63e-03	150	166	5	DOID:1612 (is_implicated_in)
Disease	aortic valve stenosis (is_marker_for)	OGT NFATC1	1.67e-03	11	166	2	DOID:1712 (is_marker_for)
Disease	Posterior Choroidal Artery Infarction	F5 PRKCH	1.67e-03	11	166	2	C0887799
Disease	Cerebral Infarction, Left Hemisphere	F5 PRKCH	1.67e-03	11	166	2	C0751010
Disease	Anterior Choroidal Artery Infarction	F5 PRKCH	1.67e-03	11	166	2	C0751012
Disease	Cerebral Infarction, Right Hemisphere	F5 PRKCH	1.67e-03	11	166	2	C0751011
Disease	Subcortical Infarction	F5 PRKCH	1.67e-03	11	166	2	C0751014
Disease	Cerebral Infarction	F5 PRKCH	1.67e-03	11	166	2	C0007785
Disease	tuberculosis (is_marker_for)	IRAK3 IL27	1.67e-03	11	166	2	DOID:399 (is_marker_for)
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	AKAP6 DMXL2 SLC22A23 CDKAL1 UBA7 MGAT3 MAST3 IL27	1.94e-03	398	166	8	EFO_0003756, EFO_0003888, EFO_0004337
Disease	intracranial aneurysm (is_implicated_in)	MMP9 ENG	2.00e-03	12	166	2	DOID:10941 (is_implicated_in)
Disease	lymphangioleiomyomatosis (is_marker_for)	RICTOR MMP9	2.00e-03	12	166	2	DOID:3319 (is_marker_for)
Disease	focal segmental glomerulosclerosis (biomarker_via_orthology)	AGT MMP9	2.00e-03	12	166	2	DOID:1312 (biomarker_via_orthology)
Disease	Myocardial Infarction	F5 AGT ATM MMP9	2.07e-03	95	166	4	C0027051
Disease	Colorectal Carcinoma	AKAP6 ZNF560 SYNE1 OBSCN F5 FAT1 KL FADS1 NF1 NFATC1 CHEK2	2.17e-03	702	166	11	C0009402
Disease	skin melanoma (is_marker_for)	AGT MMP9	2.36e-03	13	166	2	DOID:8923 (is_marker_for)
Disease	reticulocyte measurement	AMPD3 PEX12 RICTOR ITGA4 CDKAL1 GGT7 STK16 FAT1 MGAT3 USP32 CHEK2 EIF2AK1 FBXL20 USP3	2.60e-03	1053	166	14	EFO_0010700
Disease	gastric ulcer (implicated_via_orthology)	AGT MAPK1	2.74e-03	14	166	2	DOID:10808 (implicated_via_orthology)
Disease	ventricular septal defect (is_implicated_in)	NFATC1 MMP9	2.74e-03	14	166	2	DOID:1657 (is_implicated_in)
Disease	asymmetric dimethylarginine measurement	PYROXD2 ZZEF1	2.74e-03	14	166	2	EFO_0010463
Disease	type 2 diabetes mellitus (implicated_via_orthology)	OGT SLC2A2 CDKAL1 MAPK1	2.97e-03	105	166	4	DOID:9352 (implicated_via_orthology)
Disease	superior parietal cortex volume measurement	ADGRB3 MAPK1	3.15e-03	15	166	2	EFO_0010330
Disease	anemia (implicated_via_orthology)	SLC4A8 SLC4A10	3.15e-03	15	166	2	DOID:2355 (implicated_via_orthology)
Disease	thrombosis (is_implicated_in)	F5 MMP9	3.15e-03	15	166	2	DOID:0060903 (is_implicated_in)
Disease	Blood Coagulation Disorders	F5 ENG	3.58e-03	16	166	2	C0005779
Disease	Pre-Eclampsia	STOX1 AGT	3.58e-03	16	166	2	C0032914
Disease	diabetic retinopathy (implicated_via_orthology)	ITGA4 AGT	3.58e-03	16	166	2	DOID:8947 (implicated_via_orthology)
Disease	autism spectrum disorder (is_implicated_in)	ITGA4 MMP9	3.58e-03	16	166	2	DOID:0060041 (is_implicated_in)
Disease	Astrocytosis	ITGA4 MAPK1	4.05e-03	17	166	2	C3887640
Disease	pre-eclampsia (biomarker_via_orthology)	ITGA4 ENG	4.05e-03	17	166	2	DOID:10591 (biomarker_via_orthology)
Disease	Gliosis	ITGA4 MAPK1	4.05e-03	17	166	2	C0017639
Disease	Liver Cirrhosis, Experimental	SLC22A23 INPPL1 DAO FRY FAT1 CROT ARRB2 THYN1 AGT MMP9 PLOD2	4.53e-03	774	166	11	C0023893
Disease	glucuronate measurement	CHST9 MAPK1	4.54e-03	18	166	2	EFO_0010486
Disease	Hypertrophy	AGT MAPK1	4.54e-03	18	166	2	C0020564
Disease	Brain Ischemia	F5 MAPK1 MMP9	4.73e-03	60	166	3	C0007786
Disease	polycystic ovary syndrome	SOX8 LHX2 CHEK2	4.73e-03	60	166	3	EFO_0000660
Disease	Cerebral Ischemia	F5 MAPK1 MMP9	4.73e-03	60	166	3	C0917798
Disease	alkaline phosphatase measurement	SLC4A8 ZNF337 PSKH1 PGAP4 TLK1 FADS1 NF1 NFATC1 NFATC4 CHEK2 FAM227A MMP9 FBXL20	5.00e-03	1015	166	13	EFO_0004533
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	CHEK2 ATM	5.05e-03	19	166	2	C1333991
Disease	superior temporal gyrus volume measurement	ITIH5 ANKRD7	5.05e-03	19	166	2	EFO_0010331
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	CHEK2 ATM	5.05e-03	19	166	2	C2936783
Disease	mean platelet volume	SLC9A9 COL6A6 SLC22A23 DAO SIRT3 FRY TLK1 FADS1 NFATC1 SLC35B4 CHEK2 FBXL20 FGD3	5.21e-03	1020	166	13	EFO_0004584
Disease	uterine fibroid	SYNE1 DNAH2 SIRT3 CHEK2 ATM	5.47e-03	199	166	5	EFO_0000731
Disease	leprosy, Crohn's disease	SLC9A2 IL27	5.59e-03	20	166	2	EFO_0000384, EFO_0001054
Disease	Adenocarcinoma of prostate	CHEK2 ATM	5.59e-03	20	166	2	C0007112

Protein segments in the cluster

Peptide	Gene	Start	Entry
HLLICPGFHTNKNIY	nan	596	A8MVM7
AHPHILFMLLKGYEA	CAB39L	121	Q9H9S4
AQHYALLLFRVPKSH	FAM227A	221	F5H4B4
GYAALRPHLVAKHGR	ACTL10	191	Q5JWF8
YPPHQRIAASKALLH	CDK20	271	Q8IZL9
EHFLRQLQRKDPHGF	BRD9	146	Q9H8M2
PHERLLHYKVNPEFN	ADGRB3	1336	O60242
VLLLVHNLPQHLFGY	CEACAM5	51	P06731
RLAVAYKQPIHHNGF	DMXL2	1081	Q8TDJ6
ALGQRLGELHHLYAP	DNHD1	1751	Q96M86
AHYGALAGDKLILHL	ANKRD24	251	Q8TF21
QYLHENGIIHRDLKP	CHEK2	336	O96017
SEHIPLGKFYNNRAH	CEMIP	716	Q8WUJ3
FLHLQALGIPLHLAY	ENG	106	P17813
LRKLGQHAHPFFFTI	ARRB2	106	P32121
LYELPGLQHDHIVRF	AMHR2	246	Q16671
LAAGDRVYIHPFHLV	AGT	21	P01019
NPQDHRELHLFLKYV	AMPD3	506	Q01432
LFTHIQPFLGAHELY	CFAP206	346	Q8IYR0
LRNAEKVLLPGYHHF	RAG1	506	P15918
PEGRLYQHGKLTLLH	RAB3GAP1	616	Q15042
FYRKNPLHLHLVTDA	LARGE2	121	Q8N3Y3
DLSRHHGAAALKYLP	LARGE2	696	Q8N3Y3
GSHYFHKVAGQLLPL	HPF1	301	Q9NWY4
KHFILTHDPERGIYN	DAO	211	P14920
RAVLYHLSGHLQKQP	KCNH3	171	Q9ULD8
HQILFEILAKTPYGH	ANO7	256	Q6IWH7
ELLPEKHGQYGLALH	RAB3GAP2	1366	Q9H2M9
NLHRHALKPFYSLNL	FAT1	2451	Q14517
PIFPGKHYLDQLNHI	MAPK1	226	P28482
LHKDDVNGIRHLYGP	MMP9	431	P14780
GLHRLLVKVSDHGYP	PCDH20	816	Q8N6Y1
HFLLKFRLQYRPAQH	IL11RA	251	Q14626
KKNRHPDFLPYDHAR	PTPRN	736	Q16849
HRNLKPENLLYYHPG	PSKH2	181	Q96QS6
YGCIQPNKHLKHRFL	FRAS1	3746	Q86XX4
SLHGRIYCKPHFNQL	LIMA1	431	Q9UHB6
GQDHFHELYKVILLP	GNPTAB	536	Q3T906
HLYKKPAPFQRHHLG	ITIH5	811	Q86UX2
RHKVLYVFLDHFPPG	MGAT3	266	Q09327
GNRLFPAHKYILAVH	IBTK	571	Q9P2D0
YLHFGHKLLAQLLGT	MYG1	136	Q9HB07
VGVDYILQKLGFHHA	KIAA1109	4946	Q2LD37
LHPVEFAALAHYKLV	FICD	346	Q9BVA6
HRDLKPENLLYYHPG	PSKH1	216	P11801
AGKYVPAIAHLIHSL	CPVL	206	Q9H3G5
PRYKHHGAVFELQKE	ITGAE	481	P38570
LFKLGEPHHRKEHYL	PLXNA1	146	Q9UIW2
LLGDLAAHYVHRNPK	PLXNB3	1426	Q9ULL4
VKGLHEAHQLYGRLP	GGT7	236	Q9UJ14
GHDIPQYIHIFLANL	OR52E6	266	Q96RD3
HYRHVLGVPLDDRKA	SLC2A2	41	P11168
FIHGQHSPKRISFLY	MED23	66	Q9ULK4
TLLDHLGGLYKFHDR	MED23	986	Q9ULK4
LRPHAFYQVHRITGK	NFATC1	486	O95644
HGYRKAVLTPNHVEF	NAXD	196	Q8IW45
RLHFEALLQGEYPAH	LHX2	166	P50458
ALVNGAKHVPYRDHR	KIF26A	666	Q9ULI4
HFLKGLLRAPFRCYH	MMAA	11	Q8IVH4
SIHRFHGQFLLPELK	FGD3	206	Q5JSP0
LLLFHHPNILELAAY	IRAK3	216	Q9Y616
KHIGLFSSLRYNFHP	PGAP4	386	Q9BRR3
LDIHLHTPVYFFLGN	OR13J1	51	Q8NGT2
LRQHDKLAHPYRAAV	MROH1	51	Q8NDA8
VYLPIHLYGQLVHHK	RICTOR	876	Q6R327
HLHEGLPVKNGTRYI	PLOD2	716	O00469
IPLNSLKQGYRHVHL	PLCD1	721	P51178
EYEALKGLRHPHLAQ	OBSCN	7716	Q5VST9
SGGPLENHYRLKQFH	CA5A	116	P35218
VAVYLPGHFFHLLNV	GSAP	346	A4D1B5
ELFQLQIYIHHPKGA	ATM	281	Q13315
GAAHRLGLFYQLLHK	ILVBL	31	A1L0T0
APHFHIDLDGYLLKV	BMPER	451	Q8N8U9
FYIHNMGIVHRDLKP	EIF2AK1	431	Q9BQI3
GFERFHKLHYLPHRG	DCDC2B	81	A2VCK2
AKILNHPRVYAFLHI	CDKAL1	306	Q5VV42
HRFAESHLPGVNLYL	IL27	66	Q8NEV9
LLHRYPQFTASHGKK	ANKRD7	236	Q92527
VLLLVHNLPQHLFGY	CEACAM3	51	P40198
HQHKYFFLIGPPALL	FADS1	261	O60427
KLTHDYINLFHFPPL	MAP3K20	406	Q9NYL2
LLAHGYRRFLPTKDH	FBXO24	131	O75426
YFHPPAHLQARLKAA	MBNL3	231	Q9NUK0
LHNYGIVHRDLKPDN	MAST2	626	Q6P0Q8
LHNYGIVHRDLKPDN	MAST3	481	O60307
HVLLEGLHHQRPKRY	ITGA4	961	P13612
PRLGYLVAHNLLLAH	KL	261	Q9UEF7
QHRKLLTPGFHYDVL	CYP4B1	136	P13584
LHAARYPHAAVNGLF	EMC9	16	Q9Y3B6
LLLHAVFLGLDHYRP	FRY	1666	Q5TBA9
SRGKPVDAHYLGLLH	GPR146	261	Q96CH1
ERGFLGLAFHPKFRH	HHIPL2	271	Q6UWX4
HHFFKTINFPRLEAG	GRK7	451	Q8WTQ7
RILEHAIHFGYPVLL	DNAH2	3426	Q9P225
QKLLPLEEHYRFHEF	EHD1	31	Q9H4M9
LNKHIRLHAEGNTPY	PRDM13	616	Q9H4Q3
FYLILKARRVPAHGH	UTP3	281	Q9NQZ2
GLFILIHKHNLEYPD	NOC4L	311	Q9BVI4
HPPLELSHYQIKFAA	CFAP74	1016	Q9C0B2
LVQLGRIHKPDHSYG	COL6A6	2141	A6NMZ7
QLALQLAYYRLHGHP	CROT	421	Q9UKG9
HYRHALRLKPDFIDG	OGT	111	O15294
KPSIQALIHGLNRHY	PSMD14	186	O00487
APHVHILLANFYLLF	OR52K2	271	Q8NGK3
HYQPLRIFAGHLADV	TAF5	616	Q15542
HSKEALFYNHALPLP	SLC35B4	191	Q969S0
LVEGLHDGHFYALKR	STK16	36	O75716
PIIFHAGYSLKKRHF	SLC9A9	141	Q8IVB4
LQGEAPYHLLHLKID	SYNE1	1011	Q8NF91
GVFAARHIDLKPLYA	TMEM255A	111	Q5JRV8
KNLASRPYSLHAHGL	F5	1661	P12259
HGHFGLFPANYVKLL	HCLS1	471	P14317
GTLYKLHPHFSRILQ	HKDC1	861	Q2TB90
LRPHAFYQVHRITGK	NFATC4	476	Q14934
GPYGHDTNHVLLKLR	NBR1	246	Q14596
APIIELHNQKGYFLH	SLC22A23	586	A1A5C7
LFGFKLLYPDHFHLL	PPP5C	286	P53041
LLYPDHFHLLRGNHE	PPP5C	291	P53041
RTHLPNIKVHAYFAP	FBXL20	401	Q96IG2
LNTHTRIHAGYKPFV	FEZF1	331	A0PJY2
HFRGRLLNAVVHYLP	GPR182	326	O15218
ILAGKLYFPRHLDFH	PRKY	256	O43930
LYFPRHLDFHVKTGR	PRKY	261	O43930
QTHKYAPFIIIGLHL	SGPP1	286	Q9BX95
LYQKHVHTYRILPDG	INPPL1	61	O15357
PNVTHYFLRLLHDKG	SIRT3	206	Q9NTG7
NRKPYHPKLEAFISH	PXYLP1	121	Q8TE99
KHQPDFIYLRHVPLR	SLC4A8	936	Q2Y0W8
ARRKLADQYPHLHNA	SOX8	116	P57073
YILGKAQHHSPLLRL	PEX12	181	O00623
PFYFQHLDHIGRRLD	SEC24D	396	O94855
EHSHRPIQLRKGDFY	AKAP6	2096	Q13023
ILSYHKRSHQRLFPG	ANKFN1	596	Q8N957
KEFIHYLLDSHRPVG	CHST9	331	Q7L1S5
KHFRLRCLPHFYIIG	CHST15	246	Q7LFX5
LRNLEAGYKSHEFHP	USP53	756	Q70EK8
LDRFHNYILPHLRGE	TMEM240	31	Q5SV17
FKDHPTLNERYLLLH	TLK1	446	Q9UKI8
EAGHRYFQDLHSPLK	ZNF653	161	Q96CK0
GPVLHSFRVYDLRHK	ZFHX4	221	Q86UP3
YLAQHLRIHSGAKPY	ZNF384	331	Q8TF68
LILHQRIHSGEKPYG	ZNF24	266	P17028
DLIRHFNIHTGEKPY	ZNF460	406	Q14592
FQIHERPQHGKKLYD	ZNF441	156	Q8N8Z8
LHLGIYPFLLRNKNH	TTC8	216	Q8TAM2
GKTFIYHQPFQRHER	ZNF791	166	Q3KP31
LFQHLRVHTGEKPYQ	ZSCAN31	366	Q96LW9
QLFQHARIHTGEKPY	ZNF383	296	Q8NA42
QLTLHQRFHTGEKPY	ZNF573	176	Q86YE8
HKPAQHVQALLGYRY	TEP1	451	Q99973
ASLAKIGFHLYHKLP	SLC9A2	91	Q9UBY0
FHYGIKQLLRHFPPN	UBA7	681	P41226
KHGLRLHLRNPYSFT	PYROXD2	106	Q8N2H3
FHHFAPLLRKVYLVE	RNF123	321	Q5XPI4
VKPINDDFRGHLFSH	STOX1	571	Q6ZVD7
AKHQPDFIYLRHVPL	SLC4A10	966	Q6U841
QAARRKLADQYPHLH	SOX10	116	P56693
FNFALVGHLLKGYRH	NF1	2386	P21359
FQVRDHPLYHLIKAR	TTC21A	566	Q8NDW8
ILAGKIDFPRHLDFH	PRKX	256	P51817
RAHFPAALGHILIKF	PITPNM3	166	Q9BZ71
SIRLQGLHKPVYHAL	MRPL13	36	Q9BYD1
SPSKLERHYLIHAGQ	ZNF770	636	Q6IQ21
HQYFIHDKPFIRNLL	ZNF677	156	Q86XU0
RFIPLAELKSYHQAH	THYN1	171	Q9P016
RYLLDHLHLELQGGF	USP3	266	Q9Y6I4
HGPLKRLHGDYFIQT	VN1R5	231	Q7Z5H4
HFKHQRLHTRGKPYE	ZNF418	606	Q8TF45
AYLADHQRIHTGEKP	ZNF213	386	O14771
HDALNAPLHILRAIY	ZZEF1	2471	O43149
FYSHLPELHIIQIKG	ZNF600	91	Q6ZNG1
LKVHLYKHSGERPFQ	ZNF425	681	Q6IV72
HEGYVHADLKPRNIL	UHMK1	151	Q8TAS1
GLHEDLNRVHEKPYV	USP32	836	Q8NFA0
LIYLLQPGKHRLHVD	TPK1	161	Q9H3S4
SLFGHLRVHNGEKPY	ZNF560	446	Q96MR9
YAEHVLRPKNLGLAH	ZNF337	86	Q9Y3M9
HSKEDRLAYLNHLPG	TMEM101	161	Q96IK0
DYLHSQGVVHRDLKP	RPS6KA2	521	Q15349
HSLFKKGHQLLDPYL	PRKCH	31	P24723
KRFPHGIPFLADYVH	NAGA	96	P17050
HQLGKLEPHIYAVAD	MYO9A	206	B2RTY4