Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	TOP2A TOP2B	2.11e-05	4	38	2	GO:0003918
GeneOntologyMolecularFunction	protein transporter activity	TOMM7 TIMM29 AP4M1	6.93e-05	42	38	3	GO:0140318
GeneOntologyMolecularFunction	DNA topoisomerase activity	TOP2A TOP2B	9.80e-05	8	38	2	GO:0003916
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 STAB1	4.16e-04	16	38	2	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 STAB1	7.24e-04	21	38	2	GO:0030228
GeneOntologyMolecularFunction	scavenger receptor activity	LRP1 STAB1	1.20e-03	27	38	2	GO:0005044
GeneOntologyMolecularFunction	protein transmembrane transporter activity	TOMM7 AP4M1	1.29e-03	28	38	2	GO:0008320
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	TOMM7 AP4M1	1.90e-03	34	38	2	GO:0022884
GeneOntologyBiologicalProcess	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	TOP2A TOP2B	3.31e-06	2	38	2	GO:0045870
Domain	TOPRIM_C	TOP2A TOP2B	3.82e-06	2	37	2	IPR031660
Domain	TOPRIM_C	TOP2A TOP2B	3.82e-06	2	37	2	PF16898
Domain	-	TOP2A TOP2B	3.82e-06	2	37	2	3.90.199.10
Domain	DNA_topoisoIV	TOP2A TOP2B	3.82e-06	2	37	2	PF00521
Domain	Topo_IIA_A/C_ab	TOP2A TOP2B	3.82e-06	2	37	2	IPR013758
Domain	Topo_IIA_A_a	TOP2A TOP2B	3.82e-06	2	37	2	IPR013757
Domain	Topo_IIA_cen_dom	TOP2A TOP2B	3.82e-06	2	37	2	IPR013759
Domain	-	TOP2A TOP2B	3.82e-06	2	37	2	3.40.50.670
Domain	DTHCT	TOP2A TOP2B	3.82e-06	2	37	2	IPR012542
Domain	TopoIIA_CS	TOP2A TOP2B	3.82e-06	2	37	2	IPR018522
Domain	TOP4c	TOP2A TOP2B	3.82e-06	2	37	2	SM00434
Domain	TOP2c	TOP2A TOP2B	3.82e-06	2	37	2	SM00433
Domain	Topo_IIA-like_dom	TOP2A TOP2B	3.82e-06	2	37	2	IPR013760
Domain	Topo_IIA_bsu_dom2	TOP2A TOP2B	3.82e-06	2	37	2	IPR013506
Domain	DTHCT	TOP2A TOP2B	3.82e-06	2	37	2	PF08070
Domain	DNA_gyraseB	TOP2A TOP2B	3.82e-06	2	37	2	PF00204
Domain	-	TOP2A TOP2B	3.82e-06	2	37	2	1.10.268.10
Domain	Topo_IIA_A/C	TOP2A TOP2B	3.82e-06	2	37	2	IPR002205
Domain	Topo_IIA	TOP2A TOP2B	3.82e-06	2	37	2	IPR001241
Domain	TOPOISOMERASE_II	TOP2A TOP2B	3.82e-06	2	37	2	PS00177
Domain	ABC_tran_Xtn	ABCF2 ABCF1	1.14e-05	3	37	2	PF12848
Domain	-	TOP2A TOP2B	1.14e-05	3	37	2	3.30.1360.40
Domain	Arg_repress_C-like	TOP2A TOP2B	1.14e-05	3	37	2	IPR024946
Domain	ABC_tran_Xtn	ABCF2 ABCF1	1.14e-05	3	37	2	IPR032781
Domain	TOPRIM	TOP2A TOP2B	2.29e-05	4	37	2	PS50880
Domain	Toprim_domain	TOP2A TOP2B	2.29e-05	4	37	2	IPR006171
Domain	Toprim	TOP2A TOP2B	2.29e-05	4	37	2	PF01751
Domain	EGF_3	LRP1 TENM2 TNXB CNTNAP1 STAB1	9.48e-05	235	37	5	PS50026
Domain	EGF	LRP1 TENM2 TNXB CNTNAP1 STAB1	9.48e-05	235	37	5	SM00181
Domain	EGF	LRP1 TNXB CNTNAP1 STAB1	1.10e-04	126	37	4	PF00008
Domain	EGF-like_dom	LRP1 TENM2 TNXB CNTNAP1 STAB1	1.24e-04	249	37	5	IPR000742
Domain	EGF_1	LRP1 TENM2 TNXB CNTNAP1 STAB1	1.39e-04	255	37	5	PS00022
Domain	EGF-like_CS	LRP1 TENM2 TNXB CNTNAP1 STAB1	1.55e-04	261	37	5	IPR013032
Domain	EGF_2	LRP1 TENM2 TNXB CNTNAP1 STAB1	1.66e-04	265	37	5	PS01186
Domain	fn3	OBSCN FNDC7 LRRN4CL TNXB	2.88e-04	162	37	4	PF00041
Domain	FN3	OBSCN FNDC7 LRRN4CL TNXB	4.77e-04	185	37	4	SM00060
Domain	HATPase_c	TOP2A TOP2B	5.73e-04	18	37	2	SM00387
Domain	FN3	OBSCN FNDC7 LRRN4CL TNXB	6.27e-04	199	37	4	PS50853
Domain	HATPase_c	TOP2A TOP2B	6.39e-04	19	37	2	PF02518
Domain	-	TOP2A TOP2B	7.09e-04	20	37	2	3.30.565.10
Domain	FN3_dom	OBSCN FNDC7 LRRN4CL TNXB	7.53e-04	209	37	4	IPR003961
Domain	HATPase_C	TOP2A TOP2B	7.83e-04	21	37	2	IPR003594
Domain	-	TOP2A TOP2B	7.83e-04	21	37	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	TOP2A TOP2B	8.60e-04	22	37	2	IPR014721
Domain	Fibrinogen_C	TNXB CNTNAP1	1.30e-03	27	37	2	PF00147
Domain	FBG	TNXB CNTNAP1	1.50e-03	29	37	2	SM00186
Domain	-	TNXB CNTNAP1	1.60e-03	30	37	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	TNXB CNTNAP1	1.60e-03	30	37	2	IPR014716
Domain	EGF_CA	LRP1 TENM2 STAB1	1.80e-03	122	37	3	SM00179
Domain	Fibrinogen_a/b/g_C_dom	TNXB CNTNAP1	1.82e-03	32	37	2	IPR002181
Domain	FIBRINOGEN_C_2	TNXB CNTNAP1	1.82e-03	32	37	2	PS51406
Domain	FIBRINOGEN_C_1	TNXB CNTNAP1	1.82e-03	32	37	2	PS00514
Domain	EGF-like_Ca-bd_dom	LRP1 TENM2 STAB1	1.88e-03	124	37	3	IPR001881
Domain	Ribosomal_S5_D2-typ_fold	TOP2A TOP2B	2.06e-03	34	37	2	IPR020568
Domain	-	LRP1 TENM2	2.70e-03	39	37	2	2.120.10.30
Domain	ABC_transporter_CS	ABCF2 ABCF1	3.13e-03	42	37	2	IPR017871
Domain	Growth_fac_rcpt_	LRP1 TNXB STAB1	3.61e-03	156	37	3	IPR009030
Domain	6-blade_b-propeller_TolB-like	LRP1 TENM2	3.74e-03	46	37	2	IPR011042
Domain	ABC_TRANSPORTER_2	ABCF2 ABCF1	4.07e-03	48	37	2	PS50893
Domain	ABC_tran	ABCF2 ABCF1	4.07e-03	48	37	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCF2 ABCF1	4.24e-03	49	37	2	PS00211
Domain	ABC_transporter-like	ABCF2 ABCF1	4.41e-03	50	37	2	IPR003439
Pathway	BIOCARTA_DNAFRAGMENT_PATHWAY	TOP2A TOP2B	1.46e-04	10	26	2	M7239
Pathway	BIOCARTA_DNAFRAGMENT_PATHWAY	TOP2A TOP2B	1.78e-04	11	26	2	MM1349
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	SMC4 NEK1 TOP2A PCK1 PDHX TOP2B	1.10e-06	313	38	6	20800603
Pubmed	DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.	TOP2A TOP2B	1.16e-06	2	38	2	24048577
Pubmed	Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.	TOP2A TOP2B	1.16e-06	2	38	2	32218491
Pubmed	Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.	TOP2A TOP2B	1.16e-06	2	38	2	1309226
Pubmed	Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.	TOP2A TOP2B	1.16e-06	2	38	2	19222228
Pubmed	Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.	TOP2A TOP2B	1.16e-06	2	38	2	2555055
Pubmed	Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.	TOP2A TOP2B	1.16e-06	2	38	2	23399433
Pubmed	Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.	TOP2A TOP2B	1.16e-06	2	38	2	30169847
Pubmed	Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.	TOP2A TOP2B	1.16e-06	2	38	2	1331984
Pubmed	Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.	TOP2A TOP2B	1.16e-06	2	38	2	15044480
Pubmed	C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.	TOP2A TOP2B	1.16e-06	2	38	2	17526531
Pubmed	Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.	TOP2A TOP2B	1.16e-06	2	38	2	31106979
Pubmed	A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.	TOP2A TOP2B	1.16e-06	2	38	2	16091284
Pubmed	The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.	TOP2A TOP2B	1.16e-06	2	38	2	9155056
Pubmed	Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.	TOP2A TOP2B	1.16e-06	2	38	2	14596941
Pubmed	Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.	TOP2A TOP2B	1.16e-06	2	38	2	17361331
Pubmed	DNA topoisomerase II distribution in mouse preimplantation embryos.	TOP2A TOP2B	1.16e-06	2	38	2	11835579
Pubmed	Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.	TOP2A TOP2B	1.16e-06	2	38	2	10095062
Pubmed	Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.	TOP2A TOP2B	1.16e-06	2	38	2	14996935
Pubmed	Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.	TOP2A TOP2B	1.16e-06	2	38	2	2556712
Pubmed	A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.	TOP2A TOP2B	1.16e-06	2	38	2	16712776
Pubmed	Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.	TOP2A TOP2B	1.16e-06	2	38	2	8710863
Pubmed	Structural organization of the human TOP2A and TOP2B genes.	TOP2A TOP2B	1.16e-06	2	38	2	9795238
Pubmed	The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues.	TOP2A TOP2B	1.16e-06	2	38	2	8241259
Pubmed	Mining topoisomerase isoforms in gastric cancer.	TOP2A TOP2B	1.16e-06	2	38	2	32535049
Pubmed	Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.	TOP2A TOP2B	1.16e-06	2	38	2	26612825
Pubmed	An inventory of the human ABC proteins.	ABCF2 ABCF1	1.16e-06	2	38	2	10581359
Pubmed	Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.	TOP2A TOP2B	1.16e-06	2	38	2	10473615
Pubmed	Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.	TOP2A TOP2B	1.16e-06	2	38	2	1380833
Pubmed	Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.	TOP2A TOP2B	1.16e-06	2	38	2	11927602
Pubmed	Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.	TOP2A TOP2B	1.16e-06	2	38	2	17182034
Pubmed	Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.	TOP2A TOP2B	1.16e-06	2	38	2	9224616
Pubmed	DNA damage response during chromatin remodeling in elongating spermatids of mice.	TOP2A TOP2B	1.16e-06	2	38	2	18032420
Pubmed	Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.	TOP2A TOP2B	1.16e-06	2	38	2	8299728
Pubmed	Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.	TOP2A TOP2B	1.16e-06	2	38	2	22111588
Pubmed	Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.	TOP2A TOP2B	1.16e-06	2	38	2	17578914
Pubmed	Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.	TOP2A TOP2B	1.16e-06	2	38	2	28700616
Pubmed	Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.	TOP2A TOP2B	1.16e-06	2	38	2	28087392
Pubmed	Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.	TOP2A TOP2B	1.16e-06	2	38	2	28472494
Pubmed	DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.	TOP2A TOP2B	3.48e-06	3	38	2	23466610
Pubmed	Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.	TOP2A TOP2B	3.48e-06	3	38	2	17567603
Pubmed	Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.	TOP2A TOP2B	3.48e-06	3	38	2	11136718
Pubmed	Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.	TOP2A TOP2B	3.48e-06	3	38	2	10666337
Pubmed	Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.	TOP2A TOP2B	3.48e-06	3	38	2	36633090
Pubmed	Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.	TOP2A TOP2B	3.48e-06	3	38	2	16611985
Pubmed	Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).	TOP2A TOP2B	3.48e-06	3	38	2	24808172
Pubmed	Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.	TOP2A TOP2B	3.48e-06	3	38	2	12821127
Pubmed	Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.	TOP2A TOP2B	3.48e-06	3	38	2	9049244
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	SMC4 ABCF2 ABCF1 TOP2A TOP2B	5.20e-06	231	38	5	36597993
Pubmed	SUMO-1 conjugation to human DNA topoisomerase II isozymes.	TOP2A TOP2B	6.96e-06	4	38	2	10862613
Pubmed	Histone deacetylase interacts directly with DNA topoisomerase II.	TOP2A TOP2B	1.16e-05	5	38	2	11062478
Pubmed	Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.	TOP2A TOP2B	1.74e-05	6	38	2	31202577
Pubmed	Topoisomerase II regulates the maintenance of DNA methylation.	TOP2A TOP2B	2.43e-05	7	38	2	25451918
Pubmed	A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation.	TOP2A TOP2B	3.24e-05	8	38	2	33188014
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	TOP2A TOP2B	4.16e-05	9	38	2	18394993
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	SMC4 LRP1 TMEM131L ABCF2 SLC25A1 CNTNAP1	5.00e-05	613	38	6	22268729
Pubmed	Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes.	SMC4 TOP2A	5.20e-05	10	38	2	21795393
Pubmed	Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.	SMC4 TOP2A	6.35e-05	11	38	2	26919979
Pubmed	SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.	SMC4 TOP2A	7.62e-05	12	38	2	28302748
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	SMC4 SLC25A1 TOP2A TOP2B	9.89e-05	221	38	4	29991511
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	SMC4 ABCF2 SLC25A1 TOP2A PDHX TOP2B	1.05e-04	701	38	6	30196744
Pubmed	Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.	TOP2A TOP2B	1.21e-04	15	38	2	12393188
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	TIMM29 ABCF1 SLC25A1 TOP2A	1.27e-04	236	38	4	36339263
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMC4 ABCF2 IFT122 OR10G8 SLC25A1 TOP2A PCK1 TOP2B	1.38e-04	1442	38	8	35575683
Pubmed	Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.	ABCF2 NEK1 TIMM29 ABCF1 SLC25A1	1.44e-04	464	38	5	32457219
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCF2 ABCF1	2.65e-04	22	38	2	8894702
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCF2 ABCF1	2.90e-04	23	38	2	10708515
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SMC4 NEK1 KMT2B SLC25A1 TOP2A	3.14e-04	549	38	5	38280479
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	ABCF2 ABCF1 TOP2A TOP2B	4.40e-04	327	38	4	31409639
Pubmed	FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.	ABCF2 ABCF1 SLC25A1	4.66e-04	138	38	3	26752685
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	ABCF2 ABCF1 SLC25A1 TOP2A TOP2B	4.75e-04	601	38	5	33658012
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	ABCF2 ABCF1 SLC25A1 TOP2A TOP2B	5.27e-04	615	38	5	31048545
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	TOP2A TOP2B	5.65e-04	32	38	2	38060382
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	OBSCN ABCF2 TOP2A	5.82e-04	149	38	3	25184681
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	SMC4 ABCF1 SLC25A1 TOP2A TOP2B	9.67e-04	704	38	5	29955894
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	TOP2A TOP2B	9.74e-04	42	38	2	35705031
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	TOP2A TOP2B	1.02e-03	43	38	2	26030138
GeneFamily	ATP binding cassette subfamily F	ABCF2 ABCF1	5.06e-06	3	24	2	810
GeneFamily	Topoisomerases	TOP2A TOP2B	2.52e-05	6	24	2	1050
GeneFamily	Fibronectin type III domain containing	OBSCN FNDC7 LRRN4CL TNXB	5.47e-05	160	24	4	555
Coexpression	GSE12392_CD8A_POS_VS_NEG_SPLEEN_DC_DN	SMC4 LRATD2 ASXL1 NAPRT TOP2A	1.01e-05	200	38	5	M7143
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SMC4 IFT122 TIMM29 TOP2A	1.34e-05	171	38	4	b113fbebb89056af0b9c775d2fb6552206a80467
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRP1 SLC35G1 NAPRT STAB1	1.47e-05	175	38	4	5a29323d4a848ea544cdd78a0a4b73f9c122dc5e
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TMEM140 DOCK9 STAB1	1.61e-05	179	38	4	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TMEM140 DOCK9 STAB1	1.61e-05	179	38	4	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP1 LRRN4CL TNXB PCK1	1.72e-05	182	38	4	d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TMEM140 DOCK9 STAB1	1.83e-05	185	38	4	3be9e05b929ac4d956b1d53284072f668a6c1959
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TMEM140 DOCK9 STAB1	1.83e-05	185	38	4	c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TNXB TMEM140 DOCK9	2.08e-05	191	38	4	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 DENND2A LRRN4CL TNXB	2.12e-05	192	38	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 DENND2A LRRN4CL TNXB	2.12e-05	192	38	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 DENND2A LRRN4CL TNXB	2.12e-05	192	38	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SMC4 ABCF1 TENM2 TOP2A	2.21e-05	194	38	4	7a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TNXB TMEM140 DOCK9	2.21e-05	194	38	4	bc03d0f8dca9f4ba10db2f2274293f8b119e8951
ToppCell	wk_15-18-Endothelial-Lymph_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LRRN4CL TNXB TMEM140 DOCK9	2.30e-05	196	38	4	ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SMC4 LRATD2 ABCF1 TOP2A	2.34e-05	197	38	4	41bdea47b9b1f6415a866a515d1535ea942fdede
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP1 LRRN4CL TNXB PCK1	2.34e-05	197	38	4	71786e9432e2d649f5d86f639abb25e7102deb67
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A LRRN4CL TENM2 TNXB	2.44e-05	199	38	4	3835452e4848d7f7dd8651c17b746b271ef39688
ToppCell	cellseq2-Mesenchymal-Fibroblastic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LRP1 DENND2A LRRN4CL TNXB	2.48e-05	200	38	4	1c10597edd532bf172ca09870a937d35e2585081
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TNXB TOP2A PRRT3	1.85e-04	130	38	3	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_AB-8\|TCGA-Thymus / Sample_Type by Project: Shred V9	SLC35G1 DENND2A LRRN4CL	2.87e-04	151	38	3	5906562efd36fbcb91f96e0a0d3a8fe999ba1e79
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IFT122 TOP2A PRRT3	3.04e-04	154	38	3	3c9d38709f507e91ec3bcc6184cbbfa9b1250128
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IFT122 TOP2A PRRT3	3.04e-04	154	38	3	1ad4152a3e4bf5912954235fe21c2447e99f3de7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SMC4 IFT122 TOP2A	3.28e-04	158	38	3	d72d6527dc50207ddbada262460d3c4bac249a19
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	3.46e-04	161	38	3	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	3.46e-04	161	38	3	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	3.46e-04	161	38	3	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	3.52e-04	162	38	3	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AP4M1 LRRN4CL TNXB	3.52e-04	162	38	3	56f1789e69a6cb29956e46aba92b290847327c1f
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMC4 TOP2A PDHX	3.59e-04	163	38	3	3efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL TNXB STAB1	3.72e-04	165	38	3	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	DENND2A LRRN4CL TNXB	3.72e-04	165	38	3	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	3.72e-04	165	38	3	f80665b75d43f1bf6919d59fc762e7e0bac653f2
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL TNXB STAB1	3.72e-04	165	38	3	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL TNXB STAB1	3.72e-04	165	38	3	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL TNXB STAB1	3.72e-04	165	38	3	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND2A LRRN4CL STAB1	3.72e-04	165	38	3	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHKA TOP2A STAB1	3.78e-04	166	38	3	43f84d3cd58e93ce00c241656c4cba27604b4932
ToppCell	10x5'-Lung-Hematopoietic_progenitors\|Lung / Manually curated celltypes from each tissue	SMC4 TOP2A STAB1	3.85e-04	167	38	3	dec18caf0475002d4ad3c7bc7fc3050cbc8e6bae
ToppCell	BAL-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	IFT122 TOP2A PRRT3	3.85e-04	167	38	3	6c5aa9077ae7eb8887269d405972bd5b31596b19
ToppCell	10x5'-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Lung / Manually curated celltypes from each tissue	SMC4 TOP2A STAB1	3.85e-04	167	38	3	82739226347d74897be000f429b73543a031af96
ToppCell	Endothelial-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	DENND2A LRRN4CL TNXB	3.92e-04	168	38	3	4977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	3.99e-04	169	38	3	8bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	3.99e-04	169	38	3	bb43abad2c049b7f4d307737347290e01b3339a3
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	3.99e-04	169	38	3	5f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN TENM2 STAB1	4.06e-04	170	38	3	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	4.13e-04	171	38	3	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	4.13e-04	171	38	3	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	4.13e-04	171	38	3	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRN4CL DOCK9 STAB1	4.13e-04	171	38	3	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRP1 LRRN4CL TNXB	4.20e-04	172	38	3	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Endothelial-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	DENND2A LRRN4CL TNXB	4.20e-04	172	38	3	8a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	DENND2A LRRN4CL STAB1	4.20e-04	172	38	3	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	LRP1 TOP2A STAB1	4.27e-04	173	38	3	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SMC4 TMEM131L TOP2A	4.27e-04	173	38	3	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LRRN4CL DOCK9 STAB1	4.34e-04	174	38	3	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	LRRN4CL TNXB PCK1	4.34e-04	174	38	3	0f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3\|TCGA-Breast / Sample_Type by Project: Shred V9	LRRN4CL TNXB PCK1	4.34e-04	174	38	3	7f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCell	TCGA-Breast-Solid_Tissue_Normal\|TCGA-Breast / Sample_Type by Project: Shred V9	LRRN4CL TNXB PCK1	4.34e-04	174	38	3	e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell	droplet-Heart-nan-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TNXB PCK1	4.34e-04	174	38	3	cf4e0567f2a4ebe5534046b1c091af59b55bdc4f
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	LRRN4CL TNXB PCK1	4.34e-04	174	38	3	1aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	4.34e-04	174	38	3	68a6ed81e7e1f95b61f7ee20403980fa3a8db4d0
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRP1 LRRN4CL TNXB	4.34e-04	174	38	3	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	4.49e-04	176	38	3	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	DENND2A TNXB DOCK9	4.49e-04	176	38	3	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	4.49e-04	176	38	3	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	DENND2A TNXB DOCK9	4.49e-04	176	38	3	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	BAL-Mild-cDC_3\|Mild / Compartment, Disease Groups and Clusters	IFT122 CHKA CNTNAP1	4.49e-04	176	38	3	f9b0c3ced391e7ebe6b242d3f12ba14741f88d22
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	IFT122 TOP2A STAB1	4.49e-04	176	38	3	4bba41ebf9dd187c8705a6997ed039878de62b4e
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNXB DOCK9 STAB1	4.56e-04	177	38	3	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNXB DOCK9 STAB1	4.56e-04	177	38	3	66ffa279147961080c104242a08b176e301d80e3
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNXB DOCK9 STAB1	4.56e-04	177	38	3	0cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNXB TOP2A CNTNAP1	4.64e-04	178	38	3	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SMC4 TMEM131L PCK1	4.72e-04	179	38	3	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ABCF2 KMT2B STAB1	4.72e-04	179	38	3	42f3c040f504a91cc69292d39d22b5715c12526f
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRP1 TNXB CNTNAP1	4.72e-04	179	38	3	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABCF2 KMT2B STAB1	4.72e-04	179	38	3	063c05753ef1b4a18bc1ebbcae62c8cd25d11070
ToppCell	droplet-Limb_Muscle-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	4.72e-04	179	38	3	013818e173101efca7625ccd4258e60655815d73
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 LRRN4CL TNXB	4.79e-04	180	38	3	c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1 LRRN4CL TNXB	4.79e-04	180	38	3	32c6a3886428d82fb4355d987c6d2645f333447b
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A LRRN4CL TNXB	4.87e-04	181	38	3	0ec9621a078d004bbd25a587757d24b5cf162959
ToppCell	facs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND2A LRRN4CL TNXB	4.87e-04	181	38	3	c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCell	droplet-Limb_Muscle-nan-21m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	4.95e-04	182	38	3	a51cbdb8d6528a82044be838c70c492fc6370891
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TMEM131L ABCF2 DOCK9	4.95e-04	182	38	3	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMEM131L ABCF2 DOCK9	4.95e-04	182	38	3	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRP1 LRRN4CL TNXB	4.95e-04	182	38	3	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMEM131L ABCF2 DOCK9	4.95e-04	182	38	3	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMEM131L ABCF2 DOCK9	4.95e-04	182	38	3	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SMC4 LRATD2 TOP2A	5.03e-04	183	38	3	52af3c943116073c8ddd207b664342960b88929b
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	TMEM131L ABCF2 DOCK9	5.03e-04	183	38	3	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	5.11e-04	184	38	3	c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	5.11e-04	184	38	3	3bffadb0cb2e0d825bdb6cfc5d23f5436cbc3efd
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	5.19e-04	185	38	3	9954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCell	droplet-Kidney-nan-21m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	5.19e-04	185	38	3	33cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCell	droplet-Lung-nan-21m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN4CL DOCK9 STAB1	5.19e-04	185	38	3	3a4ae836e882e8d29eb0a2dfab5677f10f2d365f
ToppCell	COVID-CD4-CD8_1\|COVID / Condition, Cell_class and T cell subcluster	SLC35G1 ASXL1 TMEM140	5.19e-04	185	38	3	c634bb04a081ae3214b68f6e4a147db5b2b916ed
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCK1 DOCK9 STAB1	5.19e-04	185	38	3	a32d5cb596ebac80eb1ac301055e65d420879ec8
ToppCell	droplet-Lung-nan-21m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN4CL DOCK9 STAB1	5.19e-04	185	38	3	224f0b022c21dd40bf1f7503f00b3107ef958975
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMC4 LRRN4CL TOP2A	5.27e-04	186	38	3	ad55da1dbb173721101126826b6db9d3434cb377
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC35G1 TENM2 PCK1	5.27e-04	186	38	3	246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LRRN4CL TNXB	5.27e-04	186	38	3	a7ab70b049742dfe7ee30557031bfac6412edf52
Computational	DRG (dorsal root ganglia) genes.	LRP1 TNXB SLC25A1 PCK1 STAB1	9.03e-04	384	22	5	MODULE_2
Computational	Genes in the cancer module 3.	SMC4 ABCF1 SLC25A1 TOP2A STAB1	9.03e-04	384	22	5	MODULE_3
Computational	Neighborhood of MSH2	SMC4 TOP2A	1.46e-03	28	22	2	GNF2_MSH2
Computational	Fetal liver genes - metabolism and xenobiotics.	LRP1 TNXB SLC25A1 PCK1 STAB1	1.89e-03	453	22	5	MODULE_24
Computational	Neighborhood of SMC2L1	SMC4 TOP2A	2.03e-03	33	22	2	GNF2_SMC2L1
Computational	Neighborhood of TTK	SMC4 TOP2A	2.83e-03	39	22	2	GNF2_TTK
Computational	Neighborhood of RFC3	SMC4 TOP2A	3.12e-03	41	22	2	GNF2_RFC3
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.09e-03	47	22	2	GAVISH_3CA_METAPROGRAM_B_CELLS_CELL_CYCLE
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.09e-03	47	22	2	GAVISH_3CA_METAPROGRAM_MACROPHAGES_CELL_CYCLE
Computational	Neighborhood of HMMR	SMC4 TOP2A	4.09e-03	47	22	2	GNF2_HMMR
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.44e-03	49	22	2	GAVISH_3CA_METAPROGRAM_CD4_T_CELLS_CELL_CYCLE
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.44e-03	49	22	2	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CELL_CYCLE
Computational	Neighborhood of BUB1B	SMC4 TOP2A	4.44e-03	49	22	2	GNF2_BUB1B
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.44e-03	49	22	2	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CELL_CYCLE
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.62e-03	50	22	2	GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_CELL_CYCLE
Computational	Neighborhood of CKS2	SMC4 TOP2A	4.62e-03	50	22	2	GNF2_CKS2
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SMC4 TOP2A	4.62e-03	50	22	2	GAVISH_3CA_METAPROGRAM_EPITHELIAL_CELL_CYCLE
Computational	Liver genes - metabolism and xenobiotics.	LRP1 TNXB SLC25A1 PCK1 STAB1	4.85e-03	563	22	5	MODULE_23
Computational	Neighborhood of MCM4	SMC4 TOP2A	5.17e-03	53	22	2	GNF2_MCM4
Computational	Neighborhood of FEN1	SMC4 TOP2A	5.76e-03	56	22	2	GNF2_FEN1
Computational	Neighborhood of CDC20	SMC4 TOP2A	5.76e-03	56	22	2	GNF2_CDC20
Computational	Neighborhood of CCNB2	SMC4 TOP2A	5.96e-03	57	22	2	GNF2_CCNB2
Computational	Neighborhood of RFC4	SMC4 TOP2A	6.59e-03	60	22	2	GNF2_RFC4
Computational	Neighborhood of MCM5	SMC4 TOP2A	6.80e-03	61	22	2	GNF2_MCM5
Computational	Immune / stress response genes.	LRP1 CHKA CNTNAP1 STAB1	6.97e-03	383	22	4	MODULE_33
Computational	Neighborhood of CENPF	SMC4 TOP2A	7.02e-03	62	22	2	GNF2_CENPF
Computational	Neighborhood of CDC2	SMC4 TOP2A	7.02e-03	62	22	2	GNF2_CDC2
Computational	Neighborhood of BUB1B	ABCF1 TOP2A	7.92e-03	66	22	2	MORF_BUB1B
Computational	Neighborhood of CCNA2	SMC4 TOP2A	8.39e-03	68	22	2	GNF2_CCNA2
Computational	Neighborhood of PCNA	SMC4 TOP2A	8.39e-03	68	22	2	GNF2_PCNA
Computational	Genes in the cancer module 8.	ABCF1 CHKA SLC25A1 TOP2A	9.69e-03	421	22	4	MODULE_8
Drug	Dexrazoxane	TOP2A TOP2B	2.57e-06	2	37	2	DB00380
Drug	F14512	TOP2A TOP2B	2.57e-06	2	37	2	ctd:C534191
Drug	Daunorubicin	TOP2A TOP2B	2.57e-06	2	37	2	DB00694
Disease	B cell deficiency (implicated_via_orthology)	TOP2A TOP2B	1.45e-06	2	36	2	DOID:2115 (implicated_via_orthology)
Disease	acute myeloid leukemia (implicated_via_orthology)	TOP2A TOP2B	9.48e-05	12	36	2	DOID:9119 (implicated_via_orthology)
Disease	Disease Exacerbation	ABCF2 ABCF1 TOP2A	1.07e-03	165	36	3	C0235874
Disease	Moyamoya disease	LRP1 DOCK9	1.10e-03	40	36	2	MONDO_0016820
Disease	susceptibility to cold sores measurement	ABCF1 TNXB	2.87e-03	65	36	2	EFO_0008402
Disease	FEV/FEC ratio	LRP1 ASXL1 TNXB PDHX TOP2B DOCK9	3.42e-03	1228	36	6	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
IVAGRRYGLVGPNGK	ABCF1	326	Q8NE71
GRRYGLIGLNGIGKS	ABCF2	111	Q9UG63
RGKIGLRLGLYGCPY	CNTNAP1	156	P78357
GGEGLFYKLPGRISL	ASXL1	66	Q8IXJ9
VGKSELRGYGPGIRV	AP4M1	236	O00189
IIFGGRRPAGVPLVY	PCK1	431	P35558
SLIRYIKVIGGPPGR	IFT122	471	Q9HBG6
RRAELKGLKPGGIYV	LRRN4CL	136	Q8ND94
KREIYGRGLPERGIL	NEK1	466	Q96PY6
PLGVKLYRLGPNGIR	FNDC7	631	Q5VTL7
LFLVYGKGRPGIIRG	LRP1	526	Q07954
YLVGFPGRRSVGLVK	PDHX	16	O00330
AGEGFRYIKPVPGLL	PDZD8	41	Q8NEN9
VPGLLLREYLYGGGR	PDZD8	51	Q8NEN9
VPRVGGLLGKYIDRL	FAM217B	171	Q9NTX9
KIGGELRIGKQPYRL	LRATD2	216	Q96KN1
GRGGGLPFVIKFVSR	KMT2B	296	Q9UMN6
FGPGLFIYLRPGSRK	OR10G8	251	Q8NGN5
GRIYPDVIIGKGKTG	MGAT4D	116	A6NG13
LLKGGYIAGALPGLR	OBSCN	6901	Q5VST9
LKCIYGRPGGPVFTR	DOCK9	681	Q9BZ29
FGYCRRLLPGGKGKR	DENND2A	646	Q9ULE3
SLGPKLYGIFPQGRL	CHKA	191	P35790
RLGVRGGLVLYNLPF	PRRT3	531	Q5FWE3
VIGRDRYGVFPLRGK	TOP2B	496	Q02880
RPGRAAVYVGLLGGA	TIMM29	56	Q9BSF4
PRVGLGLARLGVYGS	TMEM140	76	Q9NV12
FGARELLKVGGRLPG	TMEM131L	721	A2VDJ0
GKDALFGVYIRRGLP	TENM2	486	Q9NT68
YGPRIGALYIRGLGE	SCLY	261	Q96I15
FLLYGLSGRKRLGPI	TNXB	3421	P22105
LLYGLLGGKRLGPVS	TNXB	3516	P22105
RFLLYGLHEGKRLGP	TNXB	3621	P22105
GLKAFYKGTVPRLGR	SLC25A1	271	P53007
EKKSGRIPGIYGRLG	SMC4	606	Q9NTJ3
RIPGIYGRLGDLGAI	SMC4	611	Q9NTJ3
GLVAGALYLRARGKP	STAB1	2491	Q9NY15
LGGVYKLVAVGGQPR	NAPRT	391	Q6XQN6
VGRDKYGVFPLRGKI	TOP2A	476	P11388
GGLLPLRAIERIGYK	ZACN	251	Q401N2
LIYRKTGFIGPKGQR	SLC35G1	116	Q2M3R5
GFIPLVIYLGFKRGA	TOMM7	26	Q9P0U1