Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA helicase activity	ERCC3 DDX12P MCM6 RFC3 DDX11	1.33e-05	62	98	5	GO:0003678
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERCC3 DDX12P POLM POLA1 MCM6 RFC3 POLA2 DDX11	4.49e-05	262	98	8	GO:0140097
GeneOntologyMolecularFunction	ATP hydrolysis activity	MYH8 ERCC3 DDX12P DDX60 RNF213 MCM6 RFC3 DDX11 ABCD1 KIF13A	6.17e-05	441	98	10	GO:0016887
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERCC3 DDX12P POLM POLA1 DDX60 FARSB MCM6 RFC3 POLA2 DDX11 RNASE1 DROSHA	7.49e-05	645	98	12	GO:0140640
GeneOntologyMolecularFunction	DNA replication origin binding	DDX12P POLA1 DDX11	8.87e-05	18	98	3	GO:0003688
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC36A1 SLCO4A1 SLC46A1 SLC38A2 SLC2A6 SLCO1A2 SLC25A13 ABCD1	9.81e-05	293	98	8	GO:0008514
GeneOntologyMolecularFunction	helicase activity	ERCC3 DDX12P DDX60 MCM6 RFC3 DDX11	1.29e-04	158	98	6	GO:0004386
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11	1.42e-04	4	98	2	GO:0045142
GeneOntologyMolecularFunction	DNA-directed DNA polymerase activity	POLM POLA1 POLA2	2.44e-04	25	98	3	GO:0003887
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ERCC3 DDX12P MCM6 RFC3 DDX11	4.07e-04	127	98	5	GO:0008094
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC36A1 SLC46A1 SLC38A2 SLCO1A2 SLC25A13 ABCD1	5.50e-04	207	98	6	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC36A1 SLC46A1 SLC38A2 SLCO1A2 SLC25A13 ABCD1	5.65e-04	208	98	6	GO:0005342
GeneOntologyMolecularFunction	thyroid hormone transmembrane transporter activity	SLCO4A1 SLCO1A2	8.39e-04	9	98	2	GO:0015349
GeneOntologyMolecularFunction	DNA polymerase activity	POLM POLA1 POLA2	8.54e-04	38	98	3	GO:0034061
GeneOntologyMolecularFunction	ATP-dependent activity	MYH8 ERCC3 DDX12P DDX60 RNF213 MCM6 RFC3 DDX11 ABCD1 KIF13A	8.67e-04	614	98	10	GO:0140657
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC36A1 SLC38A2 SLC25A13	1.07e-03	41	98	3	GO:0015175
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX12P DDX11	1.27e-03	11	98	2	GO:0043139
GeneOntologyMolecularFunction	neurotrophin binding	NTRK3 FSTL4	1.52e-03	12	98	2	GO:0043121
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX12P RFC3 DDX11	1.17e-05	10	98	3	GO:0031390
GeneOntologyCellularComponent	DNA polymerase complex	POLA1 POLA2 MAD2L2	1.07e-04	20	98	3	GO:0042575
GeneOntologyCellularComponent	alpha DNA polymerase:primase complex	POLA1 POLA2	2.16e-04	5	98	2	GO:0005658
GeneOntologyCellularComponent	apicolateral plasma membrane	NEDD4 FZD6 CRB2	3.01e-04	28	98	3	GO:0016327
MousePheno	abnormal glossopharyngeal ganglion morphology	NTRK3 NEDD4 ALDH1A2 PRDM12	2.58e-05	32	76	4	MP:0001096
Domain	MBT	L3MBTL1 SCMH1 L3MBTL4	1.08e-05	9	96	3	SM00561
Domain	MBT	L3MBTL1 SCMH1 L3MBTL4	1.08e-05	9	96	3	PS51079
Domain	MBT	L3MBTL1 SCMH1 L3MBTL4	1.54e-05	10	96	3	PF02820
Domain	Mbt	L3MBTL1 SCMH1 L3MBTL4	1.54e-05	10	96	3	IPR004092
Domain	KAZAL	FSTL4 SLCO4A1 IGFBPL1 SLCO1A2	9.06e-05	46	96	4	SM00280
Domain	KAZAL_2	FSTL4 SLCO4A1 IGFBPL1 SLCO1A2	1.26e-04	50	96	4	PS51465
Domain	Kazal_dom	FSTL4 SLCO4A1 IGFBPL1 SLCO1A2	1.36e-04	51	96	4	IPR002350
Domain	Znf_C2HC	L3MBTL1 L3MBTL4	3.87e-04	6	96	2	IPR002515
Domain	zf-C2HC	L3MBTL1 L3MBTL4	3.87e-04	6	96	2	PF01530
Domain	SAM_1	L3MBTL1 SCMH1 SEC23IP L3MBTL4	4.15e-04	68	96	4	PF00536
Domain	ZF_CCHHC	L3MBTL1 L3MBTL4	5.40e-04	7	96	2	PS51802
Domain	C2	FER1L6 NEDD4 PLCD3 ESYT3 PLCE1	5.77e-04	131	96	5	PF00168
Domain	C2	FER1L6 NEDD4 PLCD3 ESYT3 PLCE1	7.07e-04	137	96	5	SM00239
Domain	Kazal_2	FSTL4 SLCO4A1 SLCO1A2	8.31e-04	36	96	3	PF07648
Domain	C2	FER1L6 NEDD4 PLCD3 ESYT3 PLCE1	8.31e-04	142	96	5	PS50004
Domain	Sialidases	NEU3 SORCS3	9.19e-04	9	96	2	IPR011040
Domain	-	FER1L6 NEDD4 PLCD3 ESYT3 PLCE1	1.00e-03	148	96	5	2.60.40.150
Domain	SAM	L3MBTL1 SCMH1 SEC23IP L3MBTL4	1.10e-03	88	96	4	SM00454
Domain	SAM_DOMAIN	L3MBTL1 SCMH1 SEC23IP L3MBTL4	1.46e-03	95	96	4	PS50105
Domain	SAM	L3MBTL1 SCMH1 SEC23IP L3MBTL4	1.58e-03	97	96	4	IPR001660
Domain	C2_dom	FER1L6 NEDD4 PLCD3 ESYT3 PLCE1	1.58e-03	164	96	5	IPR000008
Domain	OA_transporter	SLCO4A1 SLCO1A2	1.67e-03	12	96	2	IPR004156
Domain	OATP	SLCO4A1 SLCO1A2	1.67e-03	12	96	2	PF03137
Domain	-	L3MBTL1 SCMH1 SEC23IP L3MBTL4	2.18e-03	106	96	4	1.10.150.50
Domain	MFS	SLCO4A1 SLC46A1 SLC2A6 SLCO1A2	2.34e-03	108	96	4	PS50850
Domain	EF-hand_like	PLCD3 PLCE1	2.63e-03	15	96	2	PF09279
Domain	PI-PLC-Y	PLCD3 PLCE1	2.63e-03	15	96	2	PF00387
Domain	PLCYc	PLCD3 PLCE1	2.63e-03	15	96	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCD3 PLCE1	2.63e-03	15	96	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCD3 PLCE1	2.63e-03	15	96	2	PS50008
Domain	PI-PLC_fam	PLCD3 PLCE1	2.63e-03	15	96	2	IPR001192
Domain	PLC_EF-hand-like	PLCD3 PLCE1	2.63e-03	15	96	2	IPR015359
Domain	Ig_I-set	NTRK3 FSTL4 IGFBPL1 IGDCC4 IGSF9B	2.99e-03	190	96	5	IPR013098
Domain	I-set	NTRK3 FSTL4 IGFBPL1 IGDCC4 IGSF9B	2.99e-03	190	96	5	PF07679
Domain	SAM/pointed	L3MBTL1 SCMH1 SEC23IP L3MBTL4	3.12e-03	117	96	4	IPR013761
Domain	Aa_trans	SLC36A1 SLC38A2	3.38e-03	17	96	2	PF01490
Domain	AA_transpt_TM	SLC36A1 SLC38A2	3.38e-03	17	96	2	IPR013057
Domain	PI-PLC-X	PLCD3 PLCE1	3.79e-03	18	96	2	PF00388
Domain	PLCXc	PLCD3 PLCE1	3.79e-03	18	96	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCD3 PLCE1	4.22e-03	19	96	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCD3 PLCE1	4.22e-03	19	96	2	IPR000909
Domain	MFS_dom	SLCO4A1 SLC46A1 SLC2A6 SLCO1A2	5.06e-03	134	96	4	IPR020846
Pathway	KEGG_MEDICUS_REFERENCE_ORIGIN_UNWINDING_AND_ELONGATION	POLA1 MCM6 RFC3 POLA2	1.64e-05	30	73	4	M47859
Pathway	REACTOME_DNA_STRAND_ELONGATION	POLA1 MCM6 RFC3 POLA2	2.13e-05	32	73	4	M19312
Pathway	KEGG_DNA_REPLICATION	POLA1 MCM6 RFC3 POLA2	3.44e-05	36	73	4	M16853
Pathway	REACTOME_POLYMERASE_SWITCHING	POLA1 RFC3 POLA2	4.65e-05	14	73	3	M787
Pathway	REACTOME_POLYMERASE_SWITCHING	POLA1 RFC3 POLA2	4.65e-05	14	73	3	MM15372
Pathway	WP_DNA_REPLICATION	POLA1 MCM6 RFC3 POLA2	6.38e-05	42	73	4	M39335
Pathway	REACTOME_LAGGING_STRAND_SYNTHESIS	POLA1 RFC3 POLA2	1.43e-04	20	73	3	M9461
Pathway	REACTOME_LAGGING_STRAND_SYNTHESIS	POLA1 RFC3 POLA2	1.43e-04	20	73	3	MM15374
Pathway	REACTOME_DNA_STRAND_ELONGATION	POLA1 RFC3 POLA2	2.49e-04	24	73	3	MM15375
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE	SBF1 PI4KA	2.62e-04	5	73	2	M26963
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_ER_MEMBRANE	SBF1 PI4KA	2.62e-04	5	73	2	MM14588
Pathway	REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE	POLA1 RFC3 POLA2	2.82e-04	25	73	3	MM14681
Pathway	REACTOME_POLYMERASE_SWITCHING_ON_THE_C_STRAND_OF_THE_TELOMERE	POLA1 RFC3 POLA2	3.18e-04	26	73	3	M29583
Pathway	REACTOME_PEROXISOMAL_LIPID_METABOLISM	CROT ABCD1 ACOXL	3.98e-04	28	73	3	MM15010
Pathway	REACTOME_PEROXISOMAL_LIPID_METABOLISM	CROT ABCD1 ACOXL	4.42e-04	29	73	3	M2286
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	POLA1 MCM6 POLA2	5.93e-04	32	73	3	MM15368
Pathway	PID_WNT_NONCANONICAL_PATHWAY	FLNA FZD6 PRKCZ	5.93e-04	32	73	3	M23
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	DGKQ PLCD3 PI4KA PLCE1	6.41e-04	76	73	4	M9052
Pathway	REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS	POLA1 RFC3 POLA2	6.50e-04	33	73	3	MM14683
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	POLA1 MCM6 POLA2	6.50e-04	33	73	3	M9694
Pathway	REACTOME_TELOMERE_C_STRAND_LAGGING_STRAND_SYNTHESIS	POLA1 RFC3 POLA2	7.10e-04	34	73	3	M27030
Pathway	REACTOME_DNA_REPLICATION_INITIATION	POLA1 POLA2	7.26e-04	8	73	2	MM15367
Pathway	REACTOME_DNA_REPLICATION_INITIATION	POLA1 POLA2	7.26e-04	8	73	2	M27664
Pathway	REACTOME_BETA_OXIDATION_OF_PRISTANOYL_COA	CROT ACOXL	9.30e-04	9	73	2	M27294
Pathway	REACTOME_BETA_OXIDATION_OF_PRISTANOYL_COA	CROT ACOXL	9.30e-04	9	73	2	MM14999
Pathway	REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1	POLA1 POLA2	1.16e-03	10	73	2	MM14509
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO4A1 SLCO1A2	1.41e-03	11	73	2	M930
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FLNA WFS1 NOC2L FARSB MCM6 RFC3 NDUFS3 FZD6 SLC38A2 GLB1 PI4KA SEC23IP ABCD1 CAPN15	4.11e-07	942	98	14	31073040
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLNA STK36 NUP210L RFC3 ESYT3 SCMH1 PI4KA SLC25A13 CPSF1 ABCD1 GALNT5 KIF13A	1.46e-06	754	98	12	35906200
Pubmed	Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA.	POLA1 RFC3 POLA2	1.80e-06	9	98	3	9822671
Pubmed	NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6.	NPTX2 FZD6	7.86e-06	2	98	2	30833544
Pubmed	The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replication.	POLA1 POLA2	7.86e-06	2	98	2	8223465
Pubmed	Regulation of eukaryotic DNA replication at the initiation step.	POLA1 POLA2	7.86e-06	2	98	2	12546699
Pubmed	Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.	DDX12P DDX11	7.86e-06	2	98	2	32855419
Pubmed	SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma.	SLC46A1 SLCO1A2	7.86e-06	2	98	2	33387348
Pubmed	Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA.	DDX12P DDX11	7.86e-06	2	98	2	8833153
Pubmed	Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1.	DDX12P DDX11	7.86e-06	2	98	2	9013641
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DOCK9 FSTL4 SULF1 SORCS3 IGSF9B	1.18e-05	104	98	5	10470851
Pubmed	Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.	GREB1L ALDH1A2 PRKCZ	1.18e-05	16	98	3	37852253
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA STK36 DOCK9 SLCO4A1 DGKQ ATG2A TYK2 PLCD3 SBF1 PI4KA CPSF1 ABCD1 ZNF426	1.38e-05	1105	98	13	35748872
Pubmed	Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.	POLA1 POLA2	2.35e-05	3	98	2	9518481
Pubmed	The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase alpha.	POLA1 POLA2	2.35e-05	3	98	2	9584195
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11	2.35e-05	3	98	2	17611414
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11	2.35e-05	3	98	2	21854770
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	WFS1 NTRK3 SLC25A13 CALCRL	3.52e-05	65	98	4	19598235
Pubmed	DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.	POLA1 POLA2	4.70e-05	4	98	2	8026492
Pubmed	Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.	POLA1 POLA2	4.70e-05	4	98	2	26975377
Pubmed	Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle.	POLA1 POLA2	4.70e-05	4	98	2	8463324
Pubmed	Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase.	POLA1 POLA2	4.70e-05	4	98	2	16935576
Pubmed	Molecular architecture of the mouse DNA polymerase alpha-primase complex.	POLA1 POLA2	4.70e-05	4	98	2	10523676
Pubmed	Alterations in methylation status of immune response genes promoters in cell-free DNA during a hemodialysis procedure.	IL17C TYK2	4.70e-05	4	98	2	22506826
Pubmed	A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.	POLA1 POLA2	4.70e-05	4	98	2	12181327
Pubmed	A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.	POLA1 POLA2	4.70e-05	4	98	2	22593576
Pubmed	Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase α-primase.	POLA1 POLA2	4.70e-05	4	98	2	34719824
Pubmed	The full-ORF clone resource of the German cDNA Consortium.	RNF213 CFAP74 IGSF9B	6.75e-05	28	98	3	17974005
Pubmed	Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.	FLNA PRKCZ	7.82e-05	5	98	2	18667433
Pubmed	Structure and location of the murine adrenoleukodystrophy gene.	FLNA ABCD1	7.82e-05	5	98	2	8838803
Pubmed	Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.	SLCO4A1 SLCO1A2	7.82e-05	5	98	2	10873595
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	ERCC3 POLM RFC3 POLA2	9.62e-05	84	98	4	19237606
Pubmed	HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.	FLNA POLA1 MCM6	1.01e-04	32	98	3	27114546
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA ERCC3 NOC2L POLA1 FARSB MCM6 RFC3 NDUFS3 PLCD3 SBF1 PI4KA SLC25A13 CPSF1	1.10e-04	1353	98	13	29467282
Pubmed	DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.	POLA1 POLA2	1.17e-04	6	98	2	6693436
Pubmed	Direct interaction between cohesin complex and DNA replication machinery.	POLA1 MCM6	1.64e-04	7	98	2	16438930
Pubmed	Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.	POLA1 POLA2	1.64e-04	7	98	2	28757209
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNA NOC2L POLA1 FARSB MCM6 RFC3 NDUFS3 SLC38A2 PI4KA SLC25A13 SEC23IP CPSF1 GALNT5	1.83e-04	1425	98	13	30948266
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX12P DDX11	2.18e-04	8	98	2	22678773
Pubmed	PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.	AFAP1 PRKCZ	2.18e-04	8	98	2	12134071
Pubmed	DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ.	POLA1 POLA2	2.18e-04	8	98	2	22465957
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO4A1 SLCO1A2	2.18e-04	8	98	2	19129463
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	FLNA FARSB MCM6 PI4KA SLC25A13	2.46e-04	197	98	5	31620119
Pubmed	The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.	SLCO4A1 SLCO1A2	2.79e-04	9	98	2	21486766
Pubmed	L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.	MCM6 L3MBTL1	2.79e-04	9	98	2	21149733
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	NRBP1 FLNA MYH8 POLA1 SLCO4A1 MCM6 POLA2 SLC38A2 MTRF1 SLC25A13 CPSF1 CAPN15	3.57e-04	1327	98	12	32694731
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO4A1 SLCO1A2	4.25e-04	11	98	2	14579113
Pubmed	A cell fitness selection model for neuronal survival during development.	NTRK3 ALDH1A2	5.09e-04	12	98	2	31515492
Pubmed	RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.	POLA1 POLA2	5.09e-04	12	98	2	11473323
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	MCM6 ATG2A CAPN15	5.98e-04	58	98	3	26764384
Pubmed	Molecular physiology of renal organic anion transporters.	SLCO4A1 SLCO1A2	6.01e-04	13	98	2	16403838
Pubmed	Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome.	GCM2 ALDH1A2	6.01e-04	13	98	2	16399080
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH8 PRKCZ	6.01e-04	13	98	2	8948582
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RELCH ATG2A SLC38A2 ARHGAP4 AFAP1 SBF1 SULF1	7.60e-04	529	98	7	14621295
Pubmed	CUL2LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.	POLA1 MCM6	8.06e-04	15	98	2	33590678
Pubmed	CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.	ALDH1A2 PRKCZ	8.06e-04	15	98	2	28465335
Pubmed	E3-independent monoubiquitination of ubiquitin-binding proteins.	POLM NEDD4	8.06e-04	15	98	2	17588522
Pubmed	Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.	SLC36A1 SLC38A2	8.06e-04	15	98	2	23506890
Pubmed	Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage.	NTRK3 PRDM12	8.06e-04	15	98	2	38167468
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	NRBP1 POLA1 ATG2A POLA2 PI4KA	8.23e-04	257	98	5	30945288
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	FARSB PI4KA SLC25A13 MAD2L2	8.77e-04	150	98	4	30154076
Pubmed	Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.	NEDD4 PRKCZ	9.19e-04	16	98	2	21920314
Pubmed	MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.	PRKCZ CRB2	1.04e-03	17	98	2	18403412
Pubmed	Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.	FZD6 PRKCZ	1.04e-03	17	98	2	32805026
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	NOC2L FARSB MCM6 RFC3 NDUFS3 GLB1 SLC25A13	1.11e-03	565	98	7	33567341
Pubmed	An investigation into the human serum "interactome".	IGDCC4 CROT SACS SLC25A13	1.17e-03	162	98	4	15174051
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	FZD6 PRKCZ	1.17e-03	18	98	2	29229865
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCD3 PLCE1	1.17e-03	18	98	2	1979339
Pubmed	Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.	ALDH1A2 SULF1	1.30e-03	19	98	2	20185795
Pubmed	Proteostasis is essential during cochlear development for neuron survival and hair cell polarity.	FZD6 PRKCZ	1.30e-03	19	98	2	31321879
Pubmed	The DNA sequence and analysis of human chromosome 13.	LNX2 DOCK9 MTRF1 SACS	1.39e-03	170	98	4	15057823
Pubmed	Biochemistry of mammalian peroxisomes revisited.	CROT ABCD1	1.44e-03	20	98	2	16756494
Pubmed	Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.	NTRK3 PRDM12	1.44e-03	20	98	2	33789102
Pubmed	Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1.	GCM2 ALDH1A2	1.59e-03	21	98	2	16109395
Pubmed	The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions.	NRBP1 PRKCZ	1.75e-03	22	98	2	24447338
Pubmed	Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution.	MYH8 FSTL4	1.75e-03	22	98	2	37468485
Pubmed	The apical complex couples cell fate and cell survival to cerebral cortical development.	PRKCZ CRB2	1.75e-03	22	98	2	20399730
Pubmed	PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.	NTRK3 PRDM12	1.75e-03	22	98	2	30917305
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	FZD6 PRKCZ	1.75e-03	22	98	2	34001891
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	FLNA FARSB MCM6 SLC25A13	1.79e-03	182	98	4	30711629
Pubmed	Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye.	PRKCZ CRB2	1.91e-03	23	98	2	25636444
Pubmed	Essential and supporting host cell factors for HIV-1 budding.	FLNA NEDD4	1.91e-03	23	98	2	22004035
Pubmed	Crumbs3 is essential for proper epithelial development and viability.	PRKCZ CRB2	2.08e-03	24	98	2	24164893
Pubmed	Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification.	NTRK3 IGFBPL1	2.08e-03	24	98	2	35790771
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKCZ PLCE1	2.08e-03	24	98	2	10843712
Pubmed	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	ATG2A CAPN15	2.08e-03	24	98	2	22157746
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	SLCO4A1 NDUFS3 ALDH1A2 ABCD1	2.21e-03	193	98	4	19343046
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNA NOC2L MCM6 RFC3 NDUFS3 SACS PI4KA SLC25A13 CPSF1	2.44e-03	1024	98	9	24711643
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SLCO4A1 TYK2 PLCD3 GLB1 SBF1 DROSHA PLCE1	2.46e-03	650	98	7	38777146
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	FLNA NOC2L FARSB SLC38A2 SLC25A13 SEC23IP	2.52e-03	484	98	6	31995728
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA NOC2L POLA1 MCM6 SBF1 SLC25A13 CPSF1	2.53e-03	653	98	7	22586326
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA DDX60 SBF1 PI4KA	2.61e-03	202	98	4	33005030
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	MCM6 RFC3	2.63e-03	27	98	2	27462463
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PRKCZ PLCE1	2.63e-03	27	98	2	20336759
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	NRBP1 LNX2 GPR35 NDUFS3 FZD6 SLC38A2 PRKCZ ABCD1 MAD2L2 CRB2	2.65e-03	1242	98	10	30973865
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	FLNA ERCC3 NOC2L AFAP1 GLB1 PI4KA CPSF1	2.68e-03	660	98	7	32780723
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	FLNA ERCC3 WFS1 FARSB MCM6 RFC3 NDUFS3 SLC25A13 CPSF1 PRKCZ	2.73e-03	1247	98	10	27684187
Cytoband	2q21	ERCC3 MCM6	4.04e-04	14	98	2	2q21
Cytoband	6p23	GCM2 KIF13A	4.65e-04	15	98	2	6p23
GeneFamily	DNA polymerases	POLM POLA1 POLA2 MAD2L2	1.93e-06	23	72	4	535
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL1 SCMH1 L3MBTL4	5.00e-06	9	72	3	1263
GeneFamily	Solute carriers	SLC36A1 SLCO4A1 SLC46A1 SLC38A2 SLC2A6 SLCO1A2 SLC25A13 SLC25A48	1.71e-04	395	72	8	752
GeneFamily	Sterile alpha motif domain containing	L3MBTL1 SCMH1 SEC23IP L3MBTL4	4.19e-04	88	72	4	760
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NTRK3 FSTL4 IGFBPL1 IGDCC4 IGSF9B	4.55e-04	161	72	5	593
GeneFamily	DEAD-box helicases	DDX12P DDX60 DDX11	6.22e-04	42	72	3	499
GeneFamily	DNA helicases	ERCC3 DDX11	2.05e-03	17	72	2	1167
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCD3 PLCE1	2.56e-03	19	72	2	832
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	FLNA WFS1 ATG2A POLA2 TYK2 ARHGAP4 GLB1 SBF1	9.48e-06	276	98	8	M3063
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DDX60 DOCK9 RNF213 NEDD4 RNASE1 CALCRL L3MBTL4	1.93e-07	187	98	7	f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HLA-DMB DDX60 DOCK9 RNF213 NEDD4 RNASE1 CALCRL	3.03e-07	200	98	7	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPTX2 PCDHB4 MATN4 SLITRK2 SORCS3 PLCE1	1.59e-06	162	98	6	d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPTX2 PCDHB4 MATN4 SLITRK2 SORCS3 PLCE1	1.59e-06	162	98	6	5bbd7130d4dad9035e73a439dda568195c136f31
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPTX2 PCDHB4 MATN4 SLITRK2 SORCS3 PLCE1	1.59e-06	162	98	6	eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPTX2 PCDHB4 MATN4 SLITRK2 SORCS3 PLCE1	1.59e-06	162	98	6	e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK9 FZD6 ARHGAP4 RNASE1 SULF1 CALCRL	2.74e-06	178	98	6	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 SLC46A1 AFAP1 SBF1 SLC25A13 BTNL9	2.93e-06	180	98	6	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK9 FZD6 ARHGAP4 RNASE1 CALCRL BTNL9	3.32e-06	184	98	6	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	LNX2 WFS1 FZD6 PRKCZ GALNT5 PLCE1	3.65e-06	187	98	6	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK9 FSTL4 SLCO4A1 NEDD4 SLITRK2 BTNL9	4.00e-06	190	98	6	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK9 FSTL4 SLCO4A1 SLITRK2 CALCRL BTNL9	4.12e-06	191	98	6	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK9 FSTL4 SLCO4A1 NEDD4 CALCRL BTNL9	4.12e-06	191	98	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOC2L MCM6 POLA2 GLB1 SLC25A13 CALCRL	4.50e-06	194	98	6	c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK9 FSTL4 SLCO4A1 NEDD4 CALCRL BTNL9	4.78e-06	196	98	6	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	DOCK9 FSTL4 SLCO4A1 NEDD4 CALCRL BTNL9	4.78e-06	196	98	6	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	ASK440-Epithelial-Type_1\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	WFS1 FZD6 PLCD3 RNASE1 SLCO1A2 GALNT5	4.92e-06	197	98	6	1eda2c2504451a3d626dda5c2b2b12eeaa6bca54
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	WFS1 ESYT3 SLCO1A2 PRKCZ GALNT5 PLCE1	5.06e-06	198	98	6	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SLCO4A1 RNASE1 SULF1 CALCRL BTNL9	5.06e-06	198	98	6	9e103228ac2cc86eec58bc6b8e142965228e8853
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOCK9 SLCO4A1 RNASE1 SULF1 CALCRL BTNL9	5.06e-06	198	98	6	12697db1e516c2afdb5fa1ca8caa06f4abed3382
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK9 SLCO4A1 ARHGAP4 RNASE1 CALCRL BTNL9	5.21e-06	199	98	6	9735a1dc10910f02f1106b20ae5ab4c09c21305e
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK9 SLCO4A1 RNASE1 SULF1 CALCRL BTNL9	5.36e-06	200	98	6	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK9 SLCO4A1 ARHGAP4 RNASE1 SULF1 CALCRL	5.36e-06	200	98	6	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DOCK9 FZD6 RNASE1 SLITRK2 SULF1 CALCRL	5.36e-06	200	98	6	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	DDX60 DOCK9 RNF213 NEDD4 RNASE1 CALCRL	5.36e-06	200	98	6	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HLA-DMB DOCK9 RNF213 NEDD4 RNASE1 CALCRL	5.36e-06	200	98	6	3585484c7e24e941708bee471ca607d8ccee74e6
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	DOCK9 FZD6 RNASE1 SLITRK2 SULF1 CALCRL	5.36e-06	200	98	6	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DOCK9 FZD6 ARHGAP4 RNASE1 SULF1 CALCRL	5.36e-06	200	98	6	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH8 TMPRSS4 LY6G5B ESYT3	1.07e-05	62	98	4	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH8 TMPRSS4 LY6G5B ESYT3	1.07e-05	62	98	4	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBPL1 LY6G5B ALDH1A2 SLCO1A2 IGSF9B	1.85e-05	147	98	5	989a48bda98fbff398985397a6b1189a4cbc80e7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBPL1 LY6G5B ALDH1A2 SLCO1A2 IGSF9B	1.85e-05	147	98	5	f6681c849c4c06154548bd29a094f202d1c946c2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	POLA1 DOCK9 OR52N4 CALCRL BTNL9	2.31e-05	154	98	5	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SACS IGSF9B CRB2 PLCE1	2.46e-05	156	98	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	HLA-DMB ALDH1A2 SULF1 CRB2 PLCE1	2.46e-05	156	98	5	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	HLA-DMB ALDH1A2 SULF1 CRB2 PLCE1	2.46e-05	156	98	5	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SACS IGSF9B CRB2 PLCE1	2.46e-05	156	98	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	severe-CD4+_T_naive\|World / disease stage, cell group and cell class	GREB1L AFAP1 L3MBTL1 SCMH1 SORCS3	2.54e-05	157	98	5	ccf9abe0b59e9ea728cec4bba1872ffe14c7385c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SACS SLCO1A2 CRB2 CAPN15	2.70e-05	159	98	5	9f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SACS SLCO1A2 CRB2 CAPN15	2.70e-05	159	98	5	c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ESYT3 GALNT5 NLRC3 L3MBTL4	3.25e-05	82	98	4	7f0ee8dafc37c3628506397f88fbb98fc6420bfb
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ESYT3 GALNT5 NLRC3 L3MBTL4	3.25e-05	82	98	4	c8242d273513e99107c154afb489980d11008555
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLA1 MCM6 MATN4 ALDH1A2 ACOXL	3.31e-05	166	98	5	575c325db88d6909cdf0d5e664bd9098b89d4401
ToppCell	severe-CD4+_T_naive\|severe / disease stage, cell group and cell class	GREB1L AFAP1 L3MBTL1 SCMH1 SORCS3	3.41e-05	167	98	5	02a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB4 SLCO4A1 SACS SULF1 CALCRL	3.71e-05	170	98	5	50c6c571591aa4b218caefe5778c570c809f567e
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB4 SLCO4A1 SACS SULF1 CALCRL	3.71e-05	170	98	5	8fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLA1 TMPRSS4 MCM6 ALDH1A2 ACOXL	3.71e-05	170	98	5	4ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHB4 SLCO4A1 SACS SULF1 CALCRL	3.71e-05	170	98	5	3232db50b1a40f861e981a1b9c9073b81af9f832
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR35 MTRF1 SBF1 SLC2A6 SLC25A13	3.71e-05	170	98	5	f3d5678669dcaed1836014cea543758b7ccc6b46
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	FLNA NTRK3 FSTL4 L3MBTL4 PLCE1	3.82e-05	171	98	5	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESYT3 ALDH1A2 SULF1 CRB2 PLCE1	4.03e-05	173	98	5	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC36A1 GPR35 POLA1 RFC3 TYK2	4.03e-05	173	98	5	28c98a9a54aa2cfa67464db4f628c9357ad185b9
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESYT3 ALDH1A2 SULF1 CRB2 PLCE1	4.03e-05	173	98	5	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC36A1 FZD6 SULF1 SORCS3 CALCRL	4.15e-05	174	98	5	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	normal_Lung-Endothelial_cells-EPCs\|normal_Lung / Location, Cell class and cell subclass	DOCK9 NEDD4 RNASE1 CALCRL BTNL9	4.38e-05	176	98	5	71d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK9 RFC3 SULF1 CALCRL BTNL9	4.50e-05	177	98	5	5ff8dcfb030312126695d53a026d2e104a401b83
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLCD3 ESYT3 ALDH1A2 SACS SULF1	4.75e-05	179	98	5	adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LNX2 DPP10 FSTL4 SORCS3 L3MBTL4	4.87e-05	180	98	5	b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LNX2 DPP10 FSTL4 SORCS3 L3MBTL4	4.87e-05	180	98	5	f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPTX2 MATN4 SLITRK2 SORCS3 IGSF9B	5.00e-05	181	98	5	1aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCell	PCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPTX2 MATN4 SLITRK2 SORCS3 IGSF9B	5.00e-05	181	98	5	6aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEU3 ALDH1A2 SULF1 CRB2 PLCE1	5.00e-05	181	98	5	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PCW_10-12-Neuronal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPTX2 MATN4 SLITRK2 SORCS3 IGSF9B	5.00e-05	181	98	5	381b553e2cae65ce6be100662a5f9f963353840c
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	DOCK9 SLCO4A1 NEDD4 CALCRL BTNL9	5.00e-05	181	98	5	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NEU3 ALDH1A2 SULF1 CRB2 PLCE1	5.00e-05	181	98	5	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SLCO1A2 IGSF9B CRB2 PLCE1	5.00e-05	181	98	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ALDH1A2 SLCO1A2 IGSF9B CRB2 PLCE1	5.00e-05	181	98	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Heart-LV-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DMB SLCO4A1 ATG2A SLC38A2 BTNL9	5.13e-05	182	98	5	6dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	POLA2 SLITRK2 SULF1 CRB2 PLCE1	5.13e-05	182	98	5	cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCell	droplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSTL4 MATN4 ALDH1A2 KCNF1 ACOXL	5.13e-05	182	98	5	c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FSTL4 MATN4 ALDH1A2 KCNF1 ACOXL	5.13e-05	182	98	5	3c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LNX2 WFS1 ESYT3 PRKCZ GALNT5	5.27e-05	183	98	5	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	Control-Endothelial-Endothelial-Activated_Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 RNF213 NEDD4 CALCRL KIF13A	5.27e-05	183	98	5	e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	WFS1 FZD6 ABCD1 GALNT5 PLCE1	5.27e-05	183	98	5	6821dca076318115d360ff426eb1218cfe104063
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FSTL4 MATN4 ALDH1A2 KCNF1 ACOXL	5.41e-05	184	98	5	24cbe9f2461ea920954e44bf3b2c2a6a5d4debfb
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FSTL4 MATN4 ALDH1A2 KCNF1 ACOXL	5.41e-05	184	98	5	98079fd048a63b51bbdf3833b6f15bf0ae99ea90
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FSTL4 MATN4 ALDH1A2 KCNF1 ACOXL	5.41e-05	184	98	5	86c1551c4f7c7d0c35c14852b01b1e602fa5092a
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	LNX2 WFS1 FZD6 PRKCZ PLCE1	5.41e-05	184	98	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	droplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU3 FZD6 PRKCZ BTNL9 PLCE1	5.55e-05	185	98	5	6a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCell	droplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD6 PLCD3 RNASE1 SULF1 CALCRL	5.55e-05	185	98	5	eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KCNF1 SORCS3 CRB2 PLCE1	5.55e-05	185	98	5	872720275789d249c9859de825a923803d458875
ToppCell	droplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEU3 FZD6 PRKCZ BTNL9 PLCE1	5.55e-05	185	98	5	64791056cdbb739136dbef08f4b16e2b5427faad
ToppCell	Control-Endothelial-Endothelial-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 NEDD4 RNASE1 CALCRL KIF13A	5.84e-05	187	98	5	ea9d34bcd3bd1f36745846309ede349773de501a
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK9 SLCO4A1 SLITRK2 CALCRL BTNL9	5.84e-05	187	98	5	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK9 RNASE1 IGSF9B CALCRL BTNL9	5.84e-05	187	98	5	106f50ad85a92403037214f0e94702230284837f
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DOCK9 SLC2A6 CALCRL BTNL9 NLRC3	5.84e-05	187	98	5	a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	DOCK9 SLCO4A1 RFC3 CALCRL BTNL9	5.99e-05	188	98	5	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 FZD6 RNASE1 SULF1 CALCRL	6.14e-05	189	98	5	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FZD6 PLCD3 RNASE1 SULF1 CALCRL	6.14e-05	189	98	5	2e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FZD6 ARHGAP4 RNASE1 CALCRL BTNL9	6.30e-05	190	98	5	1307688255a1250fa300edf2c41f1affe31dcc98
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK9 SLCO4A1 RFC3 CALCRL BTNL9	6.30e-05	190	98	5	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS4 MATN4 ALDH1A2 KCNF1 ACOXL	6.30e-05	190	98	5	aaf5f1c1ff7b1454f4e5dacfeb48e1c3627e3372
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS4 MATN4 ALDH1A2 KCNF1 ACOXL	6.30e-05	190	98	5	a20123d5c6cb8c2f0dfd99bbfdb571a73c36234d
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 NEDD4 RNASE1 CALCRL KIF13A	6.30e-05	190	98	5	474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK9 SLCO4A1 NEDD4 SULF1 CALCRL	6.30e-05	190	98	5	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	facs-Marrow-KLS-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOC2L MCM6 NEDD4 GLB1 CALCRL	6.30e-05	190	98	5	20f4f6fe09345878484086047061d6f900f9d476
ToppCell	Control-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	DOCK9 SLCO4A1 NEDD4 CALCRL BTNL9	6.45e-05	191	98	5	c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 NEDD4 RNASE1 CALCRL L3MBTL4	6.45e-05	191	98	5	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DOCK9 FZD6 RNASE1 SLC2A6 BTNL9	6.45e-05	191	98	5	e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK9 IGFBPL1 NEDD4 FZD6 CALCRL	6.61e-05	192	98	5	1990dc8a81594018a5bf596be99d0b5f0af0f58f
Computational	DNA replication.	POLA1 MCM6 RFC3 DDX11	8.05e-05	43	58	4	MODULE_158
Computational	Genes in the cancer module 125.	POLA1 MCM6 RFC3 DDX11	8.82e-05	44	58	4	MODULE_125
Computational	Genes in the cancer module 318.	ERCC3 MCM6 DDX11	4.44e-04	28	58	3	MODULE_318
Drug	phenyl azide	POLA1 POLA2 DROSHA CALCRL	9.43e-07	18	98	4	CID000069319
Drug	5-nitroindole	POLA1 POLA2 ARHGAP4	6.37e-06	9	98	3	CID000022523
Drug	D gap	POLA1 DGKQ POLA2	1.24e-05	11	98	3	CID000126100
Drug	dg-8-AAF	POLA1 POLA2 GLB1	1.24e-05	11	98	3	CID000105028
Drug	Kalzinol	POLM POLA1 POLA2 CROT DROSHA	1.39e-05	71	98	5	CID000105003
Drug	Brn 4268484	POLA1 POLA2	1.83e-05	2	98	2	CID000124859
Drug	2-(p-n-butylanilino)purine	POLA1 POLA2	1.83e-05	2	98	2	CID000496196
Drug	poly 5-methylthiouridylic acid	POLA1 POLA2	1.83e-05	2	98	2	CID000196324
Drug	FIACTP	POLA1 POLA2	1.83e-05	2	98	2	CID000157388
Drug	FMACTP	POLA1 POLA2	1.83e-05	2	98	2	CID000157387
Drug	2-(p-n-butylanilino)adenine	POLA1 POLA2	1.83e-05	2	98	2	CID000127307
Drug	HBGTP	POLA1 POLA2	1.83e-05	2	98	2	CID003010594
Drug	RS)-FPMPApp	POLA1 POLA2	1.83e-05	2	98	2	CID000469033
Drug	Zami 1327	POLA1 POLA2	1.83e-05	2	98	2	CID000119519
Drug	N-AcO-TFA-AF	POLA1 POLA2	1.83e-05	2	98	2	CID000119334
Drug	7-nitroindole	POLA1 POLA2	1.83e-05	2	98	2	CID000023396
Drug	pisiferic acid	POLA1 POLA2	1.83e-05	2	98	2	CID000162209
Drug	CS-92-TP	POLA1 POLA2	1.83e-05	2	98	2	CID000476778
Drug	2-(p-n-Butylanilino)-6-chloropurine	POLA1 POLA2	1.83e-05	2	98	2	CID005466207
Drug	dTTPalphaS	POLA1 POLA2	1.83e-05	2	98	2	CID000161258
Drug	difluorotoluene	STK36 POLA1 POLA2	3.39e-05	15	98	3	CID000067983
Drug	3-ketoaphidicolin	POLA1 POLA2	5.49e-05	3	98	2	CID000128472
Drug	nPrdUTP	POLA1 POLA2	5.49e-05	3	98	2	CID000122101
Drug	O2-Et-dT	POLA1 POLA2	5.49e-05	3	98	2	CID000124683
Drug	butylanilinouracil	POLA1 POLA2	5.49e-05	3	98	2	CID003080854
Drug	deoxyribose triphosphate	POLA1 POLA2	5.49e-05	3	98	2	CID000443781
Drug	N3-Et-dT	POLA1 POLA2	5.49e-05	3	98	2	CID000159912
Drug	AC1L9V70	POLA1 POLA2	5.49e-05	3	98	2	CID000501527
Drug	CdG-TP	POLA1 POLA2	5.49e-05	3	98	2	CID003081176
Drug	5-Propenyl-dutp	POLA1 POLA2	5.49e-05	3	98	2	CID006438406
Drug	ZAMI 1305	POLA1 POLA2	5.49e-05	3	98	2	CID000051665
Drug	nPrearaUTP	POLA1 POLA2	5.49e-05	3	98	2	CID011967938
Drug	AC1L2SWQ	POLA1 POLA2	5.49e-05	3	98	2	CID000127937
Drug	arazide	POLA1 POLA2	5.49e-05	3	98	2	CID000073514
Drug	SKF 101675	POLA1 POLA2	5.49e-05	3	98	2	CID000163686
Drug	isocytidine	POLA1 POLA2	5.49e-05	3	98	2	CID000065031
Drug	NSC 616960	POLA1 POLA2	5.49e-05	3	98	2	CID000092828
Drug	2'-deoxynebularine	POLA1 POLA2	5.49e-05	3	98	2	CID000065148
Drug	PMDTT	POLA1 POLA2	5.49e-05	3	98	2	CID005276920
Drug	aphidicolin-17-monoacetate	POLA1 POLA2	5.49e-05	3	98	2	CID000193852
Drug	dehydroeburiconic acid	POLA1 POLA2	5.49e-05	3	98	2	CID005316446
Drug	poly(2'-fluoro-2'-deoxyadenylic acid	POLA1 POLA2	5.49e-05	3	98	2	CID000125691
Drug	3-deoxyaphidicolin	POLA1 POLA2	5.49e-05	3	98	2	CID000135046
Drug	5-hydroxymethylchrysene sulfate	POLA1 POLA2	5.49e-05	3	98	2	CID000058130
Drug	CEdUTP	POLA1 POLA2	5.49e-05	3	98	2	CID000451675
Drug	TMPNPP	POLA1 POLA2	5.49e-05	3	98	2	CID003081855
Drug	AZTMPPNP	POLA1 POLA2	5.49e-05	3	98	2	CID003081856
Drug	AC1L1BJ2	POLM POLA1 POLA2 RNASE1	6.91e-05	51	98	4	CID000001460
Drug	Y base	FARSB RNASE1 SLCO1A2	7.13e-05	19	98	3	CID000122034
Drug	OXT-ATP	POLM POLA1 POLA2	8.36e-05	20	98	3	CID000454146
Drug	AC1L3V16	POLM POLA1 POLA2	9.72e-05	21	98	3	CID000122664
Drug	aphidicolan-16beta-ol	POLA1 POLA2	1.09e-04	4	98	2	CID000443480
Drug	C-OXT-GTP	POLA1 POLA2	1.09e-04	4	98	2	CID000454144
Drug	5-pyrimidinol	POLA1 POLA2	1.09e-04	4	98	2	CID000565855
Drug	6-nitrobenzimidazole	POLA1 POLA2	1.09e-04	4	98	2	CID000007195
Drug	AzIdUTP	POLA1 POLA2	1.09e-04	4	98	2	CID000461306
Drug	AzBdUTP	POLA1 POLA2	1.09e-04	4	98	2	CID000461305
Drug	5-(3-aminopropyl)-2'-deoxyuridine	POLA1 POLA2	1.09e-04	4	98	2	CID003081165
Drug	peyssonol A	POLA1 POLA2	1.09e-04	4	98	2	CID000460367
Drug	Gsch2cl	POLA1 POLA2	1.09e-04	4	98	2	CID000158382
Drug	FABdCTP	POLA1 POLA2	1.09e-04	4	98	2	CID003036126
Drug	hypophosphoric acid	POLA1 POLA2	1.09e-04	4	98	2	CID000024536
Drug	Bio-19-SS-dUTP	POLA1 POLA2	1.09e-04	4	98	2	CID006436409
Drug	dCTPalphaS	POLA1 POLA2	1.09e-04	4	98	2	CID000125113
Drug	5-aza-dCTP	POLA1 POLA2	1.09e-04	4	98	2	CID000126357
Drug	repandusinic acid A	POLA1 POLA2	1.09e-04	4	98	2	CID006475760
Drug	9-(4-hydroxybutyl)guanine	POLA1 POLA2	1.09e-04	4	98	2	CID000161408
Drug	2HM-HBG	POLA1 POLA2	1.09e-04	4	98	2	CID000129136
Drug	DHdTTP	POLA1 POLA2	1.09e-04	4	98	2	CID000129184
Drug	dTTP-GLY	POLA1 POLA2	1.09e-04	4	98	2	CID000129192
Drug	3'-deoxyuridine	POLA1 POLA2	1.09e-04	4	98	2	CID000145984
Drug	3'-azido-2',3'-dideoxyuridine-5'-triphosphate	POLA1 POLA2	1.09e-04	4	98	2	CID000451665
Drug	BVdUTP	POLM POLA1 POLA2	1.12e-04	22	98	3	CID006438404
Drug	Triton X-114	POLM POLA1 NEU3 MCM6 RNASE1 PI4KA	1.18e-04	177	98	6	CID000024775
Drug	BrVarafUTP	POLM POLA1 POLA2	1.47e-04	24	98	3	CID005273539
Drug	d(A-T	POLA1 POLA2 RNASE1	1.47e-04	24	98	3	CID000161272
Drug	5-formyluracil	STK36 POLA1 POLA2	1.66e-04	25	98	3	CID000304590
Drug	AC1NUK3C	STK36 POLA1 POLA2 GLB1	1.79e-04	65	98	4	CID005481064
Drug	4-aminobenzimidazole	POLA1 POLA2	1.82e-04	5	98	2	CID000020329
Drug	3-HE-dU	POLA1 POLA2	1.82e-04	5	98	2	CID000130680
Drug	2',3'-O-isopropylidenecytidine	POLA1 POLA2	1.82e-04	5	98	2	CID000351235
Drug	HO-221	POLA1 POLA2	1.82e-04	5	98	2	CID000128803
Drug	epoxy ATP	POLA1 POLA2	1.82e-04	5	98	2	CID000194127
Drug	AC1NRU4H	POLA1 POLA2	1.82e-04	5	98	2	CID005272826
Drug	AzBdUrd	POLA1 POLA2	1.82e-04	5	98	2	CID000064978
Drug	AzIdUrd	POLA1 POLA2	1.82e-04	5	98	2	CID000064979
Drug	3'-amino-2',3'-dideoxycytidine	POLA1 POLA2	1.82e-04	5	98	2	CID000073515
Drug	6-nitroso-1,2-benzopyrone	POLA1 POLA2	1.82e-04	5	98	2	CID000001871
Drug	.gamma.-Rubromycin	POLA1 POLA2	1.82e-04	5	98	2	CID005377965
Drug	VaraU	POLA1 POLA2	1.82e-04	5	98	2	CID000126501
Drug	tetrafluorobenzene	POLA1 POLA2	1.82e-04	5	98	2	CID000011084
Drug	hainanensine	POLA1 POLA2	1.82e-04	5	98	2	CID000127616
Drug	3'-thiothymidine	POLA1 POLA2	1.82e-04	5	98	2	CID000124411
Drug	beta-2'-deoxy-6-thioguanylate	POLA1 POLA2	1.82e-04	5	98	2	CID003000543
Drug	ddeCTP	POLA1 POLA2	1.82e-04	5	98	2	CID000451589
Drug	6edDTP	POLA1 POLA2	1.82e-04	5	98	2	CID003081776
Drug	8 Da	POLA1 POLA2	1.82e-04	5	98	2	CID006857701
Drug	rhodium(II) propionate	POLA1 RNASE1	1.82e-04	5	98	2	CID000151765
Drug	Oxolinic acid [14698-29-4]; Down 200; 15.4uM; HL60; HG-U133A	FLNA MOSPD3 ARHGAP4 CPSF1 ABCD1 CAPN15	1.84e-04	192	98	6	1419_DN
Drug	deoxythymidin	STK36 ERCC3 POLA1 POLA2 NEDD4 RNASE1 ABCD1	1.93e-04	276	98	7	CID000001134
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11	3.07e-05	3	95	2	DOID:0060535 (implicated_via_orthology)
Disease	hypertension	FSTL4 RNF213 NDUFS3 PLCD3 ALDH1A2 L3MBTL4 PLCE1	6.23e-05	307	95	7	EFO_0000537
Disease	primary ciliary dyskinesia (is_implicated_in)	STK36 CFAP74	1.53e-04	6	95	2	DOID:9562 (is_implicated_in)
Disease	primary dental caries	LNX2 DPP10 FSTL4	1.80e-04	34	95	3	EFO_0600095
Disease	2-arachidonoyl-GPE (20:4) measurement	ALDH1A2 SLCO1A2	2.84e-04	8	95	2	EFO_0800260
Disease	1-linoleoyl-GPE (18:2) measurement	ALDH1A2 SLCO1A2	2.84e-04	8	95	2	EFO_0800247
Disease	Moyamoya disease	DOCK9 FSTL4 RNF213	2.93e-04	40	95	3	MONDO_0016820
Disease	phosphatidylcholine measurement	NRBP1 DPP10 RFC3 GREB1L ALDH1A2 GLB1	3.20e-04	284	95	6	EFO_0010226
Disease	susceptibility to rubella infection measurement	AOPEP KIF13A L3MBTL4	6.37e-04	52	95	3	EFO_0008418
Disease	level of Phosphatidylcholine (16:1_18:1) in blood serum	GREB1L ALDH1A2	7.82e-04	13	95	2	OBA_2045082
Disease	level of Phosphatidylethanolamine (18:2_0:0) in blood serum	NRBP1 ALDH1A2	9.10e-04	14	95	2	OBA_2045143
Disease	type 1 diabetes mellitus	FSTL4 DGKQ TYK2 PI4KA ACOXL	1.13e-03	242	95	5	MONDO_0005147
Disease	Spondyloepiphyseal Dysplasia	FLNA GLB1	1.20e-03	16	95	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLNA GLB1	1.20e-03	16	95	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	FLNA GLB1	1.20e-03	16	95	2	C4551479
Disease	amyloid-beta measurement, Alzheimer's disease biomarker measurement	RELCH ALDH1A2	1.20e-03	16	95	2	EFO_0005194, EFO_0006514
Disease	Schwartz-Jampel Syndrome	FLNA GLB1	1.20e-03	16	95	2	C0036391
Disease	Melnick-Needles Syndrome	FLNA GLB1	1.20e-03	16	95	2	C0025237
Disease	Van Buchem disease	FLNA GLB1	1.35e-03	17	95	2	C0432272
Disease	retinal vasculature measurement	SLC36A1 MCM6 FZD6 CRB2 ACOXL L3MBTL4 PLCE1	1.43e-03	517	95	7	EFO_0010554
Disease	migraine disorder, systolic blood pressure	RNF213 PLCE1	1.52e-03	18	95	2	EFO_0006335, MONDO_0005277
Disease	Osteochondrodysplasias	FLNA GLB1	1.69e-03	19	95	2	C0029422
Disease	Dyschondroplasias	FLNA GLB1	1.69e-03	19	95	2	C0013366
Disease	Multiple Epiphyseal Dysplasia	FLNA GLB1	1.88e-03	20	95	2	C0026760
Disease	neuroimaging measurement, brain volume measurement	NDUFS3 ALDH1A2 AFAP1 CALCRL CRB2	2.35e-03	286	95	5	EFO_0004346, EFO_0006930
Disease	Hodgkins lymphoma	DDX12P ESYT3 AOPEP	2.38e-03	82	95	3	EFO_0000183
Disease	Renal glomerular disease	CRB2 PLCE1	2.48e-03	23	95	2	C0268731
Disease	Glomerulopathy Assessment	CRB2 PLCE1	2.48e-03	23	95	2	C4521256
Disease	aspartate aminotransferase measurement	FSTL4 RNF213 MCM6 CROT ALDH1A2 GLB1 CALCRL ACOXL PLCE1	2.56e-03	904	95	9	EFO_0004736
Disease	cortical thickness	NUP210L DOCK9 ALDH1A2 PI4KA SLCO1A2 PRKCZ CALCRL KIF13A CRB2 PLCE1	3.11e-03	1113	95	10	EFO_0004840
Disease	lysophosphatidylethanolamine 16:0 measurement	ALDH1A2 SORCS3	3.17e-03	26	95	2	EFO_0010366
Disease	amygdala volume change measurement, age at assessment	FZD6 AOPEP	3.17e-03	26	95	2	EFO_0008007, EFO_0021490
Disease	brain cancer (implicated_via_orthology)	L3MBTL1 L3MBTL4	3.17e-03	26	95	2	DOID:1319 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPLPCGVIRVHLLEA	ESYT3	301	A0FGR9
PILALVGEEVEFPCH	BTNL9	46	Q6UXG8
FTRHEPIGVCGQIIP	ALDH1A2	171	O94788
ALHRTVPAAVPGICF	ALDOB	256	P05062
HIVSIPLRGCEVIPG	AFAP1	386	Q8N556
VAPSLVRVPVAHCFG	DGKQ	111	P52824
EIIPHRVFAPVCLTG	AOPEP	396	Q8N6M6
LFCEGPRVPVVSLHS	DPP10	491	Q8N608
CSLEVILPSVHIFLP	ATG2A	811	Q2TAZ0
RSQGPHCFIVPVRDE	ACOXL	151	Q9NUZ1
AGQPVPVECRHRLEV	POLM	111	Q9NP87
RFECHIEGLPAPIIT	IGDCC4	161	Q8TDY8
GFPPLAGHCTLLVEV	PCDHA9	326	Q9Y5H5
LCQILGEAVAPAHVP	ABCD1	716	P33897
ALVVPEVVAPAGFHV	CAPN15	181	O75808
HVGPTRVEAELLPQC	RELCH	591	Q9P260
PVHPELVSGTFLCLD	MCM6	146	Q14566
FGEHIIPPSCHIIVA	OR52N4	266	Q8NGI2
AAAVLCRGPVEPLVF	SLC46A1	16	Q96NT5
PRCHTGPLDLVFVID	MATN4	26	O95460
VLDHNPPGCTFTVLV	MAD2L2	136	Q9UI95
TICTPGEVRDIRPLH	NEDD4	331	P46934
DRLICSVFPHVGEPS	NLRC3	191	Q7RTR2
RLEHCIEFVVRGNPP	NTRK3	316	Q16288
PLAATCIPIFESGVH	CRB2	406	Q5IJ48
IFVTSVPPHGCLARD	LNX2	496	Q8N448
PELCAVTFVDRPVIG	GLB1	631	P16278
ITVPACFEILLLAPH	DDX60	861	Q8IY21
HFIPVDLGAPIVQCA	CPSF1	636	Q10570
HFVRCIIPNETKTPG	MYH8	671	P13535
LDVSCFPREPIHVGA	L3MBTL1	36	Q9Y468
CEFAPVVVVPPRSVH	IGFBPL1	151	Q8WX77
RLCERFPVVVHSVTP	PI4KA	491	P42356
EGIDPRHPSVFCVLS	L3MBTL4	91	Q8NA19
EFIHVPVGCTCVLPR	IL17C	181	Q9P0M4
PFTGRVIAPEHVDIC	PRDM12	116	Q9H4Q4
AERVVEFSCGHVIPP	DDX11	641	Q96FC9
EARAPHVCRPITVAL	SLC2A6	266	Q9UGQ3
FVVCFLPLHVGLTVR	GPR35	226	Q9HC97
IGPEVAICYISSRPH	GREB1L	1821	Q9C091
SQAHCIGFPELVLPV	NOC2L	536	Q9Y3T9
IHPVVARICEPIDGI	POLA1	1216	P09884
CLHVVRIHPEPVIRF	SBF1	386	O95248
PPIIHGNLTCDTIFI	NRBP1	196	Q9UHY1
GPIEPCVLHFQVFLE	PCDHB4	96	Q9Y5E5
LRGHSLFTCEPITVP	FZD6	16	O60353
TCVVEHTGAPEPILR	HLA-DMB	191	P28068
VTCPHPDIFLVARIE	DOCK9	466	Q9BZ29
LVGVHGPRTPCEEIL	FLNA	2591	P21333
GPRTPCEEILVKHVG	FLNA	2596	P21333
GEIEIIPCSRVGHIF	GALNT5	711	Q7Z7M9
TVLTCAVHGDLRPPI	FSTL4	266	Q6MZW2
IPFIVLCHPDTIRSI	CYP4F12	96	Q9HCS2
ERVVEFSCGHVIPPD	DDX12P	661	Q92771
TVGKVPVPDIRTCHF	LY6G5B	16	Q8NDX9
VAIAEPVCRPTHVHE	ERCC3	101	P19447
VLRVTPCIPCSLEGH	SACS	2091	Q9NZJ4
GFPLIPACIHAIARS	CALCRL	261	Q16602
CPTLHFRVVGVAIDV	CFAP74	786	Q9C0B2
FVFDVIHEGCLVTPP	CROT	201	Q9UKG9
PAVEVLQVRFICAHP	NUP210L	746	Q5VU65
AVRVPAPSIEDICHV	RFC3	181	P40938
QPARGFCPREVTVEH	KIF13A	1711	Q9H1H9
VGCRLVPEHIETRPL	FER1L6	1541	Q2WGJ9
VITFPIIVHFGIRPA	DROSHA	766	Q9NRR4
VTRALHIPGCKVVPF	PLCE1	691	Q9P212
VCPVEHVHLRVPFVA	SORCS3	911	Q9UPU3
VCIHPDGVIPVLTFL	NDUFS3	86	O75489
AGDCRAIRPTVAIPH	GCM2	451	O75603
VFVGEIVCETPFRLH	SLITRK2	236	Q9H156
HTFCTRVFAGIPAPI	SLCO1A2	551	P46721
LVFVVHGIGPVCDLR	SEC23IP	446	Q9Y6Y8
PAYQGPVHCITTIVR	SLC25A48	156	Q6ZT89
VINHDRPDVCILFGP	POLA2	366	Q14181
RFVCTALPPEAVHAG	NPTX2	26	P47972
AVRLVHIPTGLVVEC	MTRF1	321	O75570
GRCKPVNTFVHEPLV	RNASE1	66	P07998
IPPTRADIIHACDIV	FARSB	351	Q9NSD9
VLEVHATVFCPPLRF	ARHGAP4	321	P98171
PHGSEFLPVVVLSVC	STK36	971	Q9NRP7
PHFICPATIGEVRGS	SCMH1	181	Q96GD3
LLGILVFSLHCPSVP	SLCO4A1	466	Q96BD0
RPHVLTPFVEECLVA	SLC25A13	191	Q9UJS0
GSVVSFRPLEIPHRC	NEU3	281	Q9UQ49
DVVTCDRGLPPVVFL	RNF213	4566	Q63HN8
EIIIPFFVSRAPEHC	SLC36A1	356	Q7Z2H8
VVLRCDVIHPVTGQP	IGSF9B	41	Q9UPX0
PLVRIEIHGVPADCA	PLCD3	686	Q8N3E9
VPILIFSFVCHPAVL	SLC38A2	296	Q96QD8
CIDIVIRHVAPIPSH	MOSPD3	91	O75425
HCVKSFPEGPAVAVR	TMPRSS4	91	Q9NRS4
LVEPVPDTHLRGITC	MID2	181	Q9UJV3
VGPPTTVRVTHKCFI	SULF1	606	Q8IWU6
PVCLHEEKTPAGRIV	ZNF426	16	Q9BUY5
RRPFLHCSTVIPVVV	TMEM267	111	Q0VDI3
LAPRFGTERVPVCHL	TYK2	266	P29597
VPVGHLVVLNVSVPC	WFS1	491	O76024
FLCGVIAIALPIHPI	KCNF1	391	Q9H3M0
CRDEGLIIHVFPSTP	PRKCZ	86	Q05513