Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentparaspeckles

PSPC1 NONO

2.30e-0410482GO:0042382
DomainNOPS

PSPC1 NONO

1.78e-053462PF08075
DomainNOPS

PSPC1 NONO

1.78e-053462IPR012975
DomainArrestin_C

ARRDC4 ARRDC2

1.65e-048462IPR014752
DomainArrestin-like_N

ARRDC4 ARRDC2

2.64e-0410462IPR011021
DomainArrestin_C-like

ARRDC4 ARRDC2

2.64e-0410462IPR011022
DomainArrestin_C

ARRDC4 ARRDC2

2.64e-0410462PF02752
DomainArrestin_N

ARRDC4 ARRDC2

2.64e-0410462PF00339
DomainArrestin_C

ARRDC4 ARRDC2

2.64e-0410462SM01017
DomainIg_E-set

ARRDC4 ARRDC2 PLXNB2

2.14e-03104463IPR014756
DomainCyt_P450_E_grp-I

CYP4V2 CYP4F22

5.49e-0345462IPR002401
DomainCyt_P450_CS

CYP4V2 CYP4F22

7.55e-0353462IPR017972
DomainQuinoprotein_ADH-like_supfam

NWD1 UTP4

7.55e-0353462IPR011047
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2L3 HLTF PRKDC

1.41e-0445323MM15508
PathwayREACTOME_E3_UBIQUITIN_LIGASES_UBIQUITINATE_TARGET_PROTEINS

UBE2L3 HLTF PRKDC

3.17e-0459323M27763
PathwayREACTOME_PROTEIN_UBIQUITINATION

UBE2L3 HLTF PRKDC

4.22e-0465323MM15490
Pubmed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.

PRKDC PSPC1 NONO

2.94e-071048328712728
Pubmed

Paraspeckles: a novel nuclear domain.

PSPC1 NONO

1.87e-06248211790299
Pubmed

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.

PSPC1 NONO

1.87e-06248232844195
Pubmed

Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog.

PSPC1 NONO

1.87e-06248225100870
Pubmed

Crystallization of a paraspeckle protein PSPC1-NONO heterodimer.

PSPC1 NONO

1.87e-06248222102035
Pubmed

Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.

PSPC1 NONO

1.87e-06248222416126
Pubmed

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.

CYP4V2 CYP4F22

1.87e-06248221540472
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

TNRC18 DNAJC10 XPO5 HLTF PRKDC PSPC1 NONO SAP130

2.95e-0665548835819319
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

UTP4 HLTF PRKDC MSI1 SSR1 PSPC1 NONO

4.47e-0648648730940648
Pubmed

P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.

PSPC1 NONO

5.59e-06348216148043
Pubmed

An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles.

PSPC1 NONO

5.59e-06348219217333
Pubmed

Synergistic upregulation of NONO and PSPC1 regulates Sertoli cell response to MEHP via modulation of ALDH1A1 signaling.

PSPC1 NONO

5.59e-06348228117896
Pubmed

PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription.

PSPC1 NONO

5.59e-06348216641145
Pubmed

Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA.

PSPC1 NONO

5.59e-06348219716791
Pubmed

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.

PRKDC PSPC1 NONO

9.76e-063048334017080
Pubmed

A genome-wide association study of neuroticism in a population-based sample.

ARRDC4 GPC6

1.12e-05448220634892
Pubmed

RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.

UBE2L3 PRKDC

1.12e-05448224979766
Pubmed

Role of Na(v)1.9 in activity-dependent axon growth in motoneurons.

SCN11A GRM7

1.12e-05448222641814
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

FRAS1 DNAJC10 PRKDC PSPC1 NONO

1.30e-0521948531353912
Pubmed

Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.

PRKDC GRM7

1.86e-05548230010942
Pubmed

Dynamic paraspeckle component localisation during spermatogenesis.

PSPC1 NONO

1.86e-05548231299635
Pubmed

The mitotic phosphorylation of p54(nrb) modulates its RNA binding activity.

PSPC1 NONO

1.86e-05548221819346
Pubmed

p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.

PSPC1 NONO

1.86e-05548212810069
Pubmed

The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange.

ARRDC4 ARRDC2

1.86e-05548216766796
Pubmed

Distinct roles of DBHS family members in the circadian transcriptional feedback loop.

PSPC1 NONO

1.86e-05548222966205
Pubmed

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.

PSPC1 NONO

5.19e-05848230550788
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

ZNF24 B4GAT1 LGALSL EFHD1 PDZD8 SSR1 PSPC1 CDKAL1

6.49e-05100748834597346
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

NUDT19 DNAJC10 ARRDC4 ARRDC2 PLXNB2

7.13e-0531348538270169
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

EFHD1 PRKDC SSR1 NONO DNAH9

9.54e-0533348532665550
Pubmed

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

TNRC18 PRKDC SAP130

9.69e-056448322865885
Pubmed

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

HLTF PSPC1 NONO

1.06e-046648332051553
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

ZNF24 DNAJC10 PRKDC PSPC1

1.18e-0418248432239614
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

ZNF24 TNRC18 XPO5 HLTF PRKDC PSPC1 NONO SAP130

1.22e-04110348834189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FRAS1 TNRC18 PDZD8 PRKDC ATG2A ARRDC2 TTC3 PLXNB2

1.24e-04110548835748872
Pubmed

IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.

PRKDC NONO

1.44e-041348230725116
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NUDT19 FRAS1 DNAJC10 UTP4 PDZD8 SSR1 TTC3 PLXNB2 CDKAL1

1.73e-04148748933957083
Pubmed

Defining the membrane proteome of NK cells.

DNAJC10 HLTF PDZD8 KIF5A PRKDC PARP14 NONO CDKAL1

1.81e-04116848819946888
Pubmed

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.

DNAJC10 XPO5 PRKDC PSPC1 NONO

1.83e-0438348529331416
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

ARRDC4 ARRDC2

1.94e-041548223236378
Pubmed

GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.

UBE2L3 PRKDC

1.94e-041548231417184
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF24 DNAJC10 XPO5 UTP4 PRKDC GPC6 PLXNB2 NONO

2.21e-04120348829180619
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

XPO5 PRKDC PSPC1 NONO

2.44e-0422048435785414
Pubmed

LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression.

PSPC1 NONO

2.50e-041748231868085
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

FRAS1 ZNF24 XPO5 PRKDC PSPC1 NONO

2.69e-0465348633742100
Pubmed

Nucleolar proteome dynamics.

UTP4 HLTF PRKDC PSPC1 NONO

2.77e-0441948515635413
Pubmed

Gestational folate deficiency alters embryonic gene expression and cell function.

MSI1 CUBN

2.81e-041848233302058
Pubmed

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

DNAJC10 B4GAT1 SSR1 CUBN PLXNB2

3.12e-0443048516303743
Pubmed

Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.

PSPC1 NONO

3.14e-041948234467244
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

XPO5 GNPTAB PARP14

3.96e-0410348310574462
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

XPO5 UTP4 HLTF PRKDC PSPC1 NONO SAP130 CDKAL1

4.07e-04131848830463901
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

DNAJC10 PSPC1 NONO SAP130 CDKAL1

4.12e-0445748532344865
Pubmed

An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.

PRKDC NONO

4.23e-042248221209461
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

UTP4 HLTF PRKDC PSPC1

4.52e-0425948430404004
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

PDZD8 SSR1 ATG2A PLXNB2 CDKAL1

4.59e-0446848531056421
Pubmed

Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.

PSPC1 NONO

4.63e-042348221670149
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

TNRC18 XPO5 SAP130

4.80e-0411048326841866
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

ZNF24 PRKDC NONO

5.60e-0411648321549307
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

ZNF24 UBE2L3 HLTF PRKDC PSPC1

5.71e-0449148536273042
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

EPS8 TNRC18 XPO5 SAP130

6.22e-0428248423667531
Pubmed

The functional interactome landscape of the human histone deacetylase family.

TNRC18 UTP4 PRKDC SAP130

6.81e-0428948423752268
Pubmed

Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.

PRKDC NONO

6.89e-042848219596686
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SCN11A TNRC18 DNAJC10 KIF5A PRKDC TTC3 PSPC1 NONO

7.37e-04144248835575683
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

XPO5 HLTF PRKDC

7.63e-0412948323022380
Pubmed

Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.

PRKDC SAP130

7.92e-043048216449650
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

PRKDC PSPC1 NONO

7.98e-0413148334551306
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

PRKDC NONO

8.45e-043148212171929
Pubmed

Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis.

NUDT19 CDKAL1

9.01e-043248217332066
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

ZNF24 PRKDC MSI1 SSR1 CDKAL1

9.26e-0454748537267103
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

NUDT19 UTP4 PDZD8 MSI1 TTC3 PSPC1 PLXNB2 CDKAL1

9.35e-04149648832877691
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EPS8 ZNF24 EFHD1 UTP4 HLTF SSR1 PSPC1 NONO

9.39e-04149748831527615
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

DNAJC10 XPO5 KIF5A PRKDC MSI1 GPC6 NONO

9.71e-04115348729845934
Pubmed

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

UBE2L3 XPO5 PRKDC SSR1

9.95e-0432048428685749
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

XPO5 UTP4 HLTF MSI1 SAP130

1.03e-0356048535241646
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

XPO5 UTP4 FAM161B PRKDC SSR1

1.06e-0356448521565611
Pubmed

USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.

DNAJC10 UTP4 TCEAL2 PRKDC SSR1

1.07e-0356548533567341
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

TNRC18 PRKDC PARP14 TTC3

1.14e-0333248437433992
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FRAS1 DNAJC10 B4GAT1 GNPTAB SSR1 PLXNB2 CDKAL1

1.23e-03120148735696571
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ZNF24 HLTF PRKDC NONO SAP130

1.23e-0358348529844126
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

HLTF PRKDC PARP14 NONO

1.24e-0334048424332808
Pubmed

ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.

PSPC1 NONO

1.27e-033848230629181
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

HLTF PSPC1 NONO

1.27e-0315448316055720
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

DNAJC10 SSR1 PSPC1 NONO

1.33e-0334648425324306
InteractionTMPRSS2 interactions

B4GAT1 XPO5 EFHD1 PDZD8 PRKDC PLXNB2 CDKAL1

1.05e-05337467int:TMPRSS2
InteractionWWP1 interactions

UBE2L3 ARRDC4 PRKDC ARRDC2 NONO LDLRAD4

2.65e-05260466int:WWP1
Cytoband19p13.11

NWD1 MPV17L2 ARRDC2

6.74e-057349319p13.11
GeneFamilyAlpha arrestins

ARRDC4 ARRDC2

5.12e-0563421311
GeneFamilyCytochrome P450 family 4

CYP4V2 CYP4F22

2.08e-03363421003
GeneFamilyUbiquitin conjugating enzymes E2

UBE2L3 UBE2L5

2.69e-0341342102
GeneFamilyRNA binding motif containing

MSI1 PSPC1 NONO

7.37e-03213343725
GeneFamilyEF-hand domain containing

EFHD1 GNPTAB PPP2R3B

7.96e-03219343863
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000

TNRC18 MSI1 GPC6 GRM7 NONO CDKAL1

3.47e-05281476gudmap_developingGonad_e18.5_epididymis_1000_k3
Diseasepsoriasis vulgaris

TRAF3IP2 UBE2L3 CDKAL1

1.28e-0461473EFO_1001494
DiseaseBilateral Wilms Tumor

XPO5 NONO

9.81e-0429472C2930471
Diseasexanthurenate measurement

GRM7 CDKAL1

9.81e-0429472EFO_0010551
DiseaseNephroblastoma

XPO5 NONO

1.51e-0336472C0027708
Diseasedentate gyrus volume measurement

TRAF3IP2 ARRDC4

1.77e-0339472EFO_0010083
Diseaseurate measurement, bone density

FRAS1 PRKDC DNAH9 LDLRAD4 CDKAL1

2.96e-03619475EFO_0003923, EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
EQDQYFEFFPPSPRS

B4GAT1

41

O43505
GPFFAYIQEFRYRPP

ARRDC2

371

Q8TBH0
PPDQQPIYFREFRFT

ATG2A

1656

Q2TAZ0
CIQEFRFQPPPLYSE

ARRDC4

386

Q8NCT1
AFAAIFDPRRYPQAP

C17orf113

516

A0A1B0GUU1
RYFQRDENAFPPTYV

NWD1

106

Q149M9
PTFYFPRGRPQDSVN

PPP2R3B

126

Q9Y5P8
SAIPYFPFIPDQPFR

LGALSL

111

Q3ZCW2
REQPPRFAQPGSFEY

NONO

251

Q15233
YDRPFQFDPSVREPK

FRAS1

3406

Q86XX4
FVNFLFVPPQFRVTY

MPV17L2

156

Q567V2
FPIPSQFELPREYRN

GNPTAB

1176

Q3T906
LPPPQFYEVRRLANF

NUDT19

256

A8MXV4
VRIYKQRPFQAPEFP

KIAA2026

481

Q5HYC2
FFTYRENPVLRAFEP

PLXNB2

976

O15031
AQFFLLYRRQPEPPA

PDZD8

21

Q8NEN9
NFRFQPRVNPVVPDY

FAM161B

361

Q96MY7
YQFPEFRVERTPLPS

MSI1

241

O43347
QDPRSPSRFLVFFYP

PARP14

46

Q460N5
PSRFLVFFYPEDVRQ

PARP14

51

Q460N5
VIRSPFFPNVYPGER

CUBN

826

O60494
APENFNTRFRPYNPE

GPC6

356

Q9Y625
FPSLFINQFYPRPGT

CDKAL1

386

Q5VV42
RYFPNPEEFQPERFF

CYP4V2

431

Q6ZWL3
RVFNPYTEFPEFSRR

EFHD1

76

Q9BUP0
PYVFDRVFPPNTTQE

KIF5A

46

Q12840
RYDFFSRVVPPDSFQ

GRM7

191

Q14831
PKEQFIPPYVPRFRN

EPS8

421

Q12929
IRPYLQDPEFNPEFV

DNAH9

3241

Q9NYC9
PRLSYPTFFPRFEFQ

HLTF

26

Q14527
PTFFPRFEFQDVIPP

HLTF

31

Q14527
ENVQRYPEIRFFPPK

DNAJC10

626

Q8IXB1
QVIYFPIRFPDVSRF

GTDC1

161

Q4AE62
LFRDPLQPQFPFCYT

ERVFC1

291

P60507
VYNPYRFDPDNPQQR

CYP4F22

446

Q6NT55
YNPFPPTNESDVIRR

UTP4

621

Q969X6
VPPQRQATFEYSFIP

SSR1

146

P43307
EPFFIYRARTPPIIN

TMEM132B

71

Q14DG7
RSREFPQFEPQRYPA

TRAF3IP2

241

O43734
FQALFSDIPPRYPFQ

TNRC18

1071

O15417
YRFPPFFTLQPNVDT

VPS25

11

Q9BRG1
PDPEIFRQRFRQFGY

ZNF24

46

P17028
QPPRFAQPGTFEFEY

PSPC1

261

Q8WXF1
FRIEINFPAEYPFKP

UBE2L5

51

A0A1B0GUS4
DNRPSVPVQFQYFLP

SAP130

476

Q9H0E3
PFVTYRPEFLPQVFS

XPO5

561

Q9HAV4
LPFQRFDITQTPPAY

TTC3

1321

P53804
RNLQDPFYPRGPREF

TCEAL2

196

Q9H3H9
SREFPPGTPRFNNYV

PRKDC

1726

P78527
YPVIFPDERNFRPFT

SCN11A

6

Q9UI33
FRIEINFPAEYPFKP

UBE2L3

51

P68036
FIQRDRFSRFQPTYP

LDLRAD4

146

O15165