Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoChylothorax

FAT4 RASA1 TSC1 MAP2K1

1.36e-0518444HP:0010310
HumanPhenoNoncommunicating hydrocephalus

DLG5 BICRA TSC1

3.27e-058443HP:0010953
HumanPhenoNeoplasm of striated muscle

NBN TSC1 DICER1 NF1

5.37e-0525444HP:0009728
HumanPhenoAbnormal pulmonary valve physiology

FAT4 KAT6A MUC5B ZEB2 ZNF469 NF1 MAP2K1 KDM6A

6.14e-05163448HP:0031654
HumanPhenoNeoplasm by histology

FAT4 APC2 NBN NLRP1 TSC1 DCC DICER1 ZEB2 BLM NF1 MAP2K1 IL6ST

6.35e-053834412HP:0011792
MousePhenoincreased classified tumor incidence

AIRE NBN TSC1 CHD2 DCC BLM HIVEP3 RINT1 NF1 TPX2 IL6ST TP53BP2

2.31e-0538110312MP:0010273
MousePhenoabnormal classified tumor incidence

AIRE NBN TSC1 CHD2 DCC BLM HIVEP3 RINT1 NF1 TPX2 IL6ST TP53BP2

2.50e-0538410312MP:0020188
MousePhenoincreased lymphoma incidence

AIRE NBN CHD2 BLM RINT1 NF1 TPX2 TP53BP2

2.80e-051641038MP:0012431
MousePhenoincreased muscle tumor incidence

TSC1 RINT1 TP53BP2

3.16e-0591033MP:0010290
MousePhenoabnormal thymus epithelium morphology

AIRE TNFRSF11A LTBR

8.14e-05121033MP:0009544
MousePhenoincreased hemolymphoid system tumor incidence

AIRE NBN CHD2 BLM RINT1 NF1 TPX2 TP53BP2

8.24e-051911038MP:0010296
MousePhenoabnormal heart septum morphology

FAT4 BICRA KAT6A RDH10 ADCY9 NF1 XIRP2 WDFY3 KLK2 KDM6A TP53BP2

1.32e-0438810311MP:0006113
MousePhenoincreased tumor incidence

AIRE SPART NBN TSC1 CHD2 DCC BLM HIVEP3 RINT1 NF1 TPX2 IL6ST TP53BP2

1.36e-0453010313MP:0002020
MousePhenoabnormal adenoma incidence

NBN TSC1 DCC RINT1 TPX2 IL6ST

1.59e-041101036MP:0020189
MousePhenoincreased adenoma incidence

NBN TSC1 DCC RINT1 TPX2 IL6ST

1.59e-041101036MP:0010383
MousePhenoincreased cystadenoma incidence

TSC1 RINT1

1.61e-0431032MP:0013751
MousePhenoincreased leiomyoma incidence

TSC1 RINT1

1.61e-0431032MP:0003569
MousePhenoincreased uterus leiomyoma incidence

TSC1 RINT1

1.61e-0431032MP:0003570
DomainZnf_FYVE_PHD

TCF20 PCLO KAT6A SYTL2 AIRE MTMR4 WDFY3 FGD6

5.84e-061471238IPR011011
DomainSH3

DLG5 RASA1 SH3D21 DOCK5 TJP1 SH3D19 SH3RF3 TP53BP2

9.27e-052161238SM00326
DomainSH3

DLG5 RASA1 SH3D21 DOCK5 TJP1 SH3D19 SH3RF3 TP53BP2

9.27e-052161238PS50002
DomainSH3_domain

DLG5 RASA1 SH3D21 DOCK5 TJP1 SH3D19 SH3RF3 TP53BP2

1.05e-042201238IPR001452
DomainNUT

NUTM2G NUTM2F

4.25e-0451232IPR024310
DomainNUT_N

NUTM2G NUTM2F

4.25e-0451232IPR024309
DomainNUT

NUTM2G NUTM2F

4.25e-0451232PF12881
DomainCLIC

CLIC6 CLIC2

6.34e-0461232IPR002946
DomainPIN_dom

NOB1 DIS3

6.34e-0461232IPR002716
DomainPINc

NOB1 DIS3

6.34e-0461232SM00670
DomainFYVE

MTMR4 WDFY3 FGD6

8.99e-04291233PF01363
DomainFYVE

MTMR4 WDFY3 FGD6

8.99e-04291233SM00064
DomainZnf_FYVE-rel

MTMR4 WDFY3 FGD6

1.44e-03341233IPR017455
DomainDNA/RNA_helicase_DEAH_CS

EP400 CHD2 BLM

1.56e-03351233IPR002464
DomainZnf_FYVE

MTMR4 WDFY3 FGD6

1.99e-03381233IPR000306
DomainDEAH_ATP_HELICASE

EP400 CHD2 BLM

1.99e-03381233PS00690
DomainZF_FYVE

MTMR4 WDFY3 FGD6

2.31e-03401233PS50178
DomainH15

KAT6A HP1BP3

3.20e-03131232SM00526
DomainH15

KAT6A HP1BP3

3.20e-03131232PS51504
DomainHistone_H1/H5_H15

KAT6A HP1BP3

3.72e-03141232IPR005818
DomainRasGAP

RASA1 NF1

3.72e-03141232SM00323
DomainRasGAP_CS

RASA1 NF1

3.72e-03141232IPR023152
DomainRasGAP

RASA1 NF1

4.27e-03151232PF00616
DomainRAS_GTPASE_ACTIV_1

RASA1 NF1

4.27e-03151232PS00509
DomainSpectrin_alpha_SH3

SH3D21 TP53BP2

4.27e-03151232IPR013315
DomainRAS_GTPASE_ACTIV_2

RASA1 NF1

4.27e-03151232PS50018
Domainfn3

ABI3BP SPEG DCC IL6ST MYBPC3

4.39e-031621235PF00041
DomainSH3_1

RASA1 DOCK5 SH3D19 SH3RF3 TP53BP2

4.62e-031641235PF00018
DomainPost-SET_dom

SETD1A SETDB1

4.86e-03161232IPR003616
DomainPostSET

SETD1A SETDB1

4.86e-03161232SM00508
DomainPOST_SET

SETD1A SETDB1

4.86e-03161232PS50868
DomainHelicase_C

EP400 CHD2 DICER1 BLM

5.49e-031071234PF00271
DomainHELICc

EP400 CHD2 DICER1 BLM

5.49e-031071234SM00490
DomainHelicase_C

EP400 CHD2 DICER1 BLM

5.67e-031081234IPR001650
DomainHELICASE_CTER

EP400 CHD2 DICER1 BLM

5.86e-031091234PS51194
DomainHELICASE_ATP_BIND_1

EP400 CHD2 DICER1 BLM

5.86e-031091234PS51192
DomainDEXDc

EP400 CHD2 DICER1 BLM

5.86e-031091234SM00487
DomainHelicase_ATP-bd

EP400 CHD2 DICER1 BLM

6.05e-031101234IPR014001
DomainRasGAP_dom

RASA1 NF1

6.14e-03181232IPR001936
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

USP53 TFEB DLG5 TCF20 KIF26B SEC24A PTK2B VPS13D MTMR4 NF1 DCP1B TJP1 SH3D19 MAP2K1 FGD6 SH3RF3 TP53BP2 MAP3K2

3.03e-098611281836931259
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

USP53 SETD1A EP400 BICRA APC2 NUP214 SH3D21 MS4A10 DOCK5 ZNF469 XIRP2 TPX2 TP53BP2

7.71e-094301281335044719
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

SETD1A NBN BLM KDM6A

5.15e-0718128417500065
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

GNL3L TCF20 EP400 SYTL2 NBN TSC1 NUP214 DICER1 ADCY9 SETDB1 MTMR4 DCP1B TJP1 TPX2

5.74e-077331281434672954
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SETD1A TCF20 EP400 SF3A1 NBN DIS3 HP1BP3 NDC1 TPX2 INTS9

5.87e-073411281032971831
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TFEB SETD1A CRYBG2 MAN2A2 EP400 BICRA SPEG GRK6 KAT6A NOB1 RDH10 NUP214 ADCY9 HIVEP3 WDFY3 MYRF ABCC10

6.78e-0711051281735748872
Pubmed

Human transcription factor protein interaction networks.

SETD1A TCF20 EP400 BICRA SEC24A ZBTB9 GCM1 NBN NUP214 DBN1 ZEB2 HP1BP3 BLM SETDB1 DCP1B TPX2 MRPS15 DLAT KDM6A

1.26e-0614291281935140242
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

TCF20 EP400 ZBTB9 NBN ZNF518A BLM TPX2 SENP6

1.80e-06222128837071664
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GNL3L EP400 SF3A1 SPART NBN TSC1 NUP214 DBN1 DIS3 HP1BP3 TJP1 SH3D19 TPX2 SENP6 TP53BP2

1.92e-069341281533916271
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TCF20 EP400 RBL1 BICRA PCLO NLRP1 ZEB2 ZNF518A NUTM2F KDM6A

2.35e-063981281035016035
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

GNL3L SPEG TSC1 CHD2 NUP214 HP1BP3 BLM VPS13D XIRP2 ASCC2 SH3RF3

2.46e-064971281136774506
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

KAT6A NLRP1 DCC HP1BP3 BLM PTK2B GZMB DLAT TP53BP2

2.58e-06313128920800603
Pubmed

Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

AIRE TNFRSF11A LTBR

2.69e-068128321441458
Pubmed

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.

AIRE TNFRSF11A LTBR

2.69e-068128327401343
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

DLG5 TCF20 POLD2 ZBTB9 SPART NUP214 DICER1 INTS9

3.41e-06242128834011540
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

GNL3L EP400 RBL1 BICRA TPRN KAT6A SPTLC1 ZBTB9 NBN DICER1 ADCY9 ZNF518A SETDB1 ZNF469 DLAT WDFY3

3.66e-0611161281631753913
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TCF20 EP400 SF3A1 NBN NUP214 DBN1 BLM NF1 GZMB TPX2 SENP6 APPL1 KDM6A

6.01e-067741281315302935
Pubmed

p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.

NF1 MAP2K1 KLK2

7.86e-061112839852579
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

USP53 ZNF444 GNL3L RASA1 ERV3-1 BICRA WASF3 KAT6A RDH10 CHD2 HP1BP3 DOCK5 HIVEP3 PTPRE TJP1 LTBR SH3RF3 KDM6A

9.15e-0614891281828611215
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

TFEB DLG5 EP400 TPRN SPART NBN TSC1 DIS3 BLM SETDB1 SENP6

1.20e-055881281138580884
Pubmed

Functional proteomics mapping of a human signaling pathway.

TPRN SYTL2 SPART ZEB2 ZNF518A SETDB1 MTMR4 DCP1B ASCC2 KDM6A TP53BP2

1.26e-055911281115231748
Pubmed

MicroRNAs are indispensable for reprogramming mouse embryonic fibroblasts into induced stem cell-like cells.

KIF26B DICER1

1.34e-052128222737231
Pubmed

Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.

GZMH GZMB

1.34e-05212823485287
Pubmed

RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.

RASA1 NF1

1.34e-052128229127119
Pubmed

Granzyme B in injury, inflammation, and repair.

GZMH GZMB

1.34e-052128223099058
Pubmed

A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice.

GZMH GZMB

1.34e-052128218222115
Pubmed

p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.

RASA1 DCC

1.34e-052128226710849
Pubmed

APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus.

APC2 TP53BP2

1.34e-052128210646860
Pubmed

Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma.

GZMH GZMB

1.34e-052128233737344
Pubmed

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

GZMH GZMB

1.34e-052128222017873
Pubmed

Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.

GZMH GZMB

1.34e-052128218836177
Pubmed

Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).

GZMH GZMB

1.34e-05212822402757
Pubmed

Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells.

GZMH GZMB

1.34e-052128216901729
Pubmed

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.

GZMH GZMB

1.34e-052128215069086
Pubmed

The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.

GZMH GZMB

1.34e-052128221177822
Pubmed

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.

GZMH GZMB

1.34e-052128232696761
Pubmed

Metallophilic macrophages are fully developed in the thymus of autoimmune regulator (Aire)-deficient mice.

AIRE LTBR

1.34e-052128219148669
Pubmed

Requirement of MHC class I on radioresistant cells for granzyme B expression from CD8+ T cells in murine contact hypersensitivity.

GZMH GZMB

1.34e-052128229428817
Pubmed

Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.

GZMH GZMB

1.34e-052128223642129
Pubmed

Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes.

GZMH GZMB

1.34e-05212823518058
Pubmed

Structure and evolutionary origin of the human granzyme H gene.

GZMH GZMB

1.34e-05212822049336
Pubmed

Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.

GZMH GZMB

1.34e-052128225495009
Pubmed

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

GZMH GZMB

1.34e-05212828137431
Pubmed

Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.

GZMH GZMB

1.34e-052128228798348
Pubmed

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

GZMH GZMB

1.34e-052128217661907
Pubmed

A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.

GZMH GZMB

1.34e-052128215356127
Pubmed

Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.

GZMH GZMB

1.34e-052128216405654
Pubmed

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.

NF1 MAP3K2

1.34e-052128233177525
Pubmed

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.

GZMH GZMB

1.34e-052128222792290
Pubmed

Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII.

GZMH GZMB

1.34e-05212823264185
Pubmed

Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells.

GZMH GZMB

1.34e-052128237298408
Pubmed

Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla.

AIRE LTBR

1.34e-052128218056347
Pubmed

Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.

GZMH GZMB

1.34e-052128223663075
Pubmed

Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.

GZMH GZMB

1.34e-05212822193684
Pubmed

Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.

GZMH GZMB

1.34e-052128224113190
Pubmed

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.

GZMH GZMB

1.34e-05212822300587
Pubmed

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

GZMH GZMB

1.34e-052128217179148
Pubmed

Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.

GZMH GZMB

1.34e-052128233674611
Pubmed

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

GZMH GZMB

1.34e-05212827566124
Pubmed

Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease.

GZMH GZMB

1.34e-052128226392464
Pubmed

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.

GZMH GZMB

1.34e-052128232473350
Pubmed

Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity.

GZMH GZMB

1.34e-052128221964027
Pubmed

Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization.

GZMH GZMB

1.34e-052128227716898
Pubmed

Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.

GZMH GZMB

1.34e-052128229445095
Pubmed

Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.

RASA1 NF1

1.34e-052128212730209
Pubmed

Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells.

AIRE LTBR

1.34e-052128218566406
Pubmed

Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.

GZMH GZMB

1.34e-052128229107333
Pubmed

Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.

GZMH GZMB

1.34e-052128225367158
Pubmed

Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.

GZMH GZMB

1.34e-05212822007574
Pubmed

Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.

GZMH GZMB

1.34e-052128232407293
Pubmed

GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.

BICRA TJP1

1.34e-052128235218185
Pubmed

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.

GZMH GZMB

1.34e-052128222236998
Pubmed

Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.

AIRE LTBR

1.34e-052128223585674
Pubmed

Differential expression of granzyme B and C in murine cytotoxic lymphocytes.

GZMH GZMB

1.34e-052128219414782
Pubmed

Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.

GZMH GZMB

1.34e-052128224791744
Pubmed

Activated mouse B cells lack expression of granzyme B.

GZMH GZMB

1.34e-052128222427643
Pubmed

Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.

GZMH GZMB

1.34e-052128216280358
Pubmed

Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.

GZMH GZMB

1.34e-05212827493755
Pubmed

Mediation of the DCC apoptotic signal by DIP13 alpha.

DCC APPL1

1.34e-052128212011067
Pubmed

Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.

GZMH GZMB

1.34e-052128219136373
Pubmed

Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells.

GZMH GZMB

1.34e-052128234183776
Pubmed

Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.

GZMH GZMB

1.34e-052128232504614
Pubmed

Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

GZMH GZMB

1.34e-052128215699143
Pubmed

Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.

TSC1 BLM

1.34e-052128216288003
Pubmed

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression.

GZMH GZMB

1.34e-052128219915065
Pubmed

Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.

GZMH GZMB

1.34e-052128233436591
Pubmed

A human MAP kinase interactome.

USP53 TCF20 ABI3BP KIF26B BICRA NUP214 SETDB1 SH3D19 MAP2K1 MAP3K2

1.35e-054861281020936779
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

SETD1A TCF20 EP400 NBN CHD2 DBN1 BLM TJP1 TPX2

1.63e-05394128927248496
Pubmed

Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.

PTK2B NF1 TJP1 APPL1 MAP2K1

1.71e-0586128510862698
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

APC2 GPR37L1 AIRE CLIC6 ZEB2 SETDB1 HEATR6 TJP1 SH3D19 SENP6 DLAT CD74 APPL1 WDFY3 REPS2 KDM6A

2.10e-0512851281635914814
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

WASF3 DICER1 DIS3 ADCY9 ZNF518A APPL1 WDFY3

2.10e-05225128712168954
Pubmed

FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis.

AIRE TNFRSF11A TJP1

2.14e-0515128331552487
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP53 SETD1A DLG5 EP400 SPART DICER1 DIS3 ADCY9 SENP6 IGSF1

2.78e-055291281014621295
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

TCF20 SF3A1 CHD2 NUP214 DICER1 DIS3 HP1BP3 BLM NF1 TJP1 DLAT

3.14e-056531281122586326
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

TPRN SEC24A NBN TSC1 ADCY9 BLM RINT1 MTMR4 NDC1 PTPRE TJP1 MAPK11 KDM6A TP53BP2

3.39e-0510491281427880917
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SETD1A TCF20 EP400 NBN DBN1 TJP1 SH3D19 TPX2 KDM6A TP53BP2

3.80e-055491281038280479
Pubmed

Wilms Tumor Predisposition

DICER1 BLM NF1

3.82e-0518128320301471
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SETD1A EP400 NUP214 DICER1 BLM SETDB1 NF1 TPX2 ASCC2

3.87e-05440128934244565
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SETD1A GNL3L TCF20 EP400 POLD2 NOB1 TSC1 CHD2 NUP214 DIS3 BLM NF1 MRPS15 DLAT WDFY3 TP53BP2

3.91e-0513531281629467282
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

NLRP1 DICER1 DIS3 WDFY3 MYRF

3.91e-05102128510231032
InteractionYWHAB interactions

TFEB DLG5 KIF26B SEC24A SPEG WASF3 KAT6A TSC1 VPS13D MTMR4 NF1 DCP1B TJP1 SH3D19 CD74 APPL1 MAP2K1 FGD6 SH3RF3 TP53BP2 MAP3K2

1.08e-06101412521int:YWHAB
InteractionYWHAH interactions

USP53 TFEB DLG5 TCF20 KIF26B SEC24A SPEG TSC1 VPS13D MTMR4 NF1 DCP1B TJP1 SH3D19 APPL1 MAP2K1 FGD6 SH3RF3 TP53BP2 MAP3K2

1.44e-05110212520int:YWHAH
InteractionYWHAZ interactions

TFEB DLG5 KIF26B SEC24A SPEG WASF3 KAT6A TSC1 VPS13D MTMR4 NF1 DCP1B TJP1 SH3D19 DLAT CD74 APPL1 WDFY3 MAP2K1 FGD6 TP53BP2 MAP3K2

1.89e-05131912522int:YWHAZ
GeneFamilyChloride intracellular channels

CLIC6 CLIC2

3.01e-046822307
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

MTMR4 WDFY3 FGD6

3.69e-043182381
CoexpressionGSE3982_MAST_CELL_VS_TH1_DN

GNL3L RBL1 HP1BP3 BLM HIVEP3 NF1 GZMB TPX2

5.40e-061981268M5454
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

RASA1 SPEG KAT6A CHD2 FBXL20 KDM6A IL6ST

4.52e-071621287b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CRYBG2 SYTL2 MUC5B CLIC6 DBN1 IGSF1 MYRF

6.77e-0717212870be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

CHD2 ZEB2 NF1 KDM6A IL6ST TP53BP2 MAP3K2

1.23e-061881287ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-062001287a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-062001287dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-0620012873bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-06200128721bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-062001287a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

USP53 ZEB2 HIVEP3 PTPRE CD74 SH3RF3 IL6ST

1.85e-06200128733036d21c1c82109284473a515c4f890b33fdd5c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SETD1A CRYBG2 RDH10 ZEB2 GZMH GZMB

6.73e-06159128657df5c9b678a15eb5e025e1a80de2e6769cc13d5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZEB2 PTPRE KLF1 GZMH GZMB CD74

7.23e-061611286bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCelldroplet-Lung-LUNG-1m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MDM1 DOCK5 PTK2B PTPRE XIRP2 MAP2K1

1.16e-051751286c8cfe0ac0c1ac447c626a623cc49692a0b177a1c
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MDM1 DOCK5 PTK2B PTPRE XIRP2 MAP2K1

1.16e-05175128661fbd8f685d3daad46449e4c0386a38886496566
ToppCellfacs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TPRN SYTL2 ADCY9 MTMR4 MRPS15 REPS2

1.28e-05178128689f0537459a321ded956bf70ad56fefc0854f8b0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 KIF26B PCLO MUC5B DCC XIRP2

1.55e-0518412862cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 KIF26B PCLO MUC5B DCC XIRP2

1.55e-051841286ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 KIF26B PCLO MUC5B DCC XIRP2

1.55e-0518412862b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYTL2 DBN1 ZEB2 DOCK5 GZMH GZMB

1.69e-051871286d17352f769c3c66601b65d060626eecff41b0482
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL15A1 ABI3BP ZEB2 XIRP2 SH3D19 KIAA1755

1.85e-05190128696a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RASA1 ANKUB1 ZEB2 MAP2K1 KDM6A IL6ST

2.03e-051931286779276e775cb2492e8dd36436295a536084a6415
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP53 FAT4 ABI3BP DBN1 SH3D19 KIAA1755

2.15e-051951286f54bc4454270ff06e85596f98199372b50d0179f
ToppCell(1)_T_cells-(1)_T_CD8_CTL|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TFEB ZEB2 GZMH GZMB CD74 MYRF

2.21e-051961286ad9b0651cb2a15b750e453b2dcf782bca08b4fe7
ToppCellmLN-T_cell-gd_T|T_cell / Region, Cell class and subclass

KIF26B SYTL2 ZEB2 SH3D21 BLM TPX2

2.21e-0519612868f476408cd5a4ea9d25c763c66565343d7989b38
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WASF3 DOCK5 PTPRE TJP1 REPS2 MYRF

2.27e-0519712868d5097898dd01cedb04cb694cb480c931e08462c
ToppCellSevere-CD8+_T_activated|Severe / Disease group and Cell class

DBN1 DOCK5 PTK2B GZMH GZMB CD74

2.27e-051971286bb1e3e1d841c2c7141eb1099e7755860b168b6fc
ToppCellSevere-CD8+_T_activated|World / Disease group and Cell class

DBN1 DOCK5 PTK2B GZMH GZMB CD74

2.34e-0519812865ff98c9b6c8c6863767b76c7745f263568f86acc
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_plasma|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DENND5B AMPD1 SEC24A DCC ENAM PTK2B

2.34e-051981286567fcf882c8612356946240843525b786f3c8dbe
ToppCellmyeloid-Dendritic_cell-Conventional_dendritic_cell|World / Lineage, cell class and subclass

ZEB2 ENHO PTPRE CLIC2 CD74 MAP2K1

2.34e-0519812862ec42643200aa9feb33e2b87570f276fbad21cad
ToppCellmyeloid-Dendritic_cell|World / Lineage, cell class and subclass

ZEB2 ENHO PTPRE CLIC2 CD74 MAP2K1

2.34e-051981286240fff8264caeb7d1efcbccb187fe93744559bbc
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

NLRP1 ZEB2 DOCK5 PTK2B PTPRE MAP2K1

2.34e-051981286d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellmLN-T_cell-CD8_T|T_cell / Region, Cell class and subclass

SYTL2 DBN1 ZEB2 GZMH GZMB CD74

2.47e-052001286650916c6d2bcf00315c7a21088cb63f37bf24346
ToppCellTCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9

DLG5 TSC1 ZNF518A DLAT KDM6A

4.44e-051351285ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TFEB ANKUB1 TPRN SPTLC1 MYRF

4.77e-051371285b03f19b233c1c809f2cd2b4a7642eeaf254a6289
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

GZMH GZMB INTS9 ABCC10

7.20e-05771284ebb1a537751739232820a60f88911877fc683855
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL15A1 GRK6 TPX2 MAPK11 MYRF

8.05e-051531285c4dcdcaa672929c1da870e9fb8ada1bb030ad12f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RDH10 PRR22 MUC5B MAPK11 MYBPC3

8.56e-05155128562b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZEB2 DOCK5 KLF1 GZMH GZMB

1.02e-041611285a480107b1c7773f2081afca2657e0b7fc88a5645
ToppCell343B-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AMPD1 ANKUB1 DCC SH3D21 ENAM

1.12e-041641285cf62d34ce9dd220fe61748466c84fd70d9ba697c
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic-dendritic_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DOCK5 ENHO PTPRE CLIC2 REPS2

1.12e-0416412853088d5fa240d2f4a6e21281f7ac932aea2f9af49
ToppCell343B-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AMPD1 ANKUB1 DCC SH3D21 ENAM

1.12e-041641285e00549bc8b3a5566f39031f39d7e698b0b107a7f
ToppCellcontrol-Myeloid-pDC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC168 ZEB2 PTPRE GZMB SH3RF3

1.15e-041651285243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DOCK5 ENHO PTPRE CLIC2 REPS2

1.18e-041661285479391aa6c09aa070b716128ab51b8fec0aea22d
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICRA BLM NDC1 MAPK11 ABCC10

1.21e-041671285bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellControl-Lymphocytic_B-B_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND5B NLRP1 PTK2B CLEC17A CD74

1.21e-041671285a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCellControl-Lymphocytic_B|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND5B NLRP1 PTK2B CLEC17A CD74

1.21e-041671285956da82394fd6a9f45fc2031796f12cc889542cd
ToppCellControl-Lymphocytic_B-B_cells-B-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DENND5B NLRP1 PTK2B CLEC17A CD74

1.21e-04167128569ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCelldroplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MDM1 DOCK5 PTK2B PTPRE MAP2K1

1.25e-041681285d823979335ac6b5d1f062ebb741c759d2f919dbf
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP3 WASF3 RDH10 MUC5B CLIC6

1.25e-041681285b275e951ff7109e36da22fc17bd4516f9b9432c4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP3 WASF3 RDH10 MUC5B CLIC6

1.25e-0416812850757a5af953901a8faed5774ffec4755fc9c0a6e
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENPP3 WASF3 RDH10 MUC5B CLIC6

1.25e-041681285a0dbe2ee697e29b32aa5f8326445e067ff66c154
ToppCell368C-Lymphocytic-NK_cells-NK_cell_C|368C / Donor, Lineage, Cell class and subclass (all cells)

BICRA SPEG BLM DOCK5 GZMH

1.25e-0416812850372c06b70f0ba95bf8cd1363ca7c5f31207f094
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MDM1 NBN DOCK5 PTK2B PTPRE

1.25e-0416812854b5be7c6662eceddf90a65015f12908278d1664e
ToppCellInt-URO-Lymphocyte-B-B_intermediate|Int-URO / Disease, Lineage and Cell Type

DENND5B MS4A10 CD74 ACSM6 MYRF

1.25e-0416812855b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MDM1 NBN DOCK5 PTK2B PTPRE

1.25e-041681285689c41f6e9f65381570991cc311cba49a57ec955
ToppCelldroplet-Lung-30m-Hematologic-myeloid-non-classical_monocyte|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MDM1 DOCK5 PTK2B PTPRE MAP2K1

1.25e-041681285f377ff4c066a9857ad14d245e56325ad220e22e1
ToppCelldroplet-Lung-nan-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MDM1 NBN DOCK5 PTK2B PTPRE

1.28e-041691285ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8|GI_small-bowel / Manually curated celltypes from each tissue

PALMD ZEB2 GZMH CD74 TP53BP2

1.28e-04169128517568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCelldroplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MDM1 NBN DOCK5 PTK2B PTPRE

1.28e-041691285c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

DLG5 BICRA GPR37L1 DICER1 MTMR4

1.32e-0417012850f215911b5880eeffeb43230f7eeaf55b612eaf2
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFEB TNFRSF11A HIVEP3 NDC1 PTPRE

1.36e-041711285d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

ZEB2 GZMH GZMB CD74 NUTM2F

1.43e-0417312851e8a43ff32eab95857c794e0bf4f0b0dba155b4a
ToppCellIIF-Myeloid-pDC|IIF / Disease, Lineage and Cell Type

KIF26B SLC9C2 ENAM PTPRE GZMB

1.51e-04175128535cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCellBAL-Control-cDC_11|Control / Compartment, Disease Groups and Clusters

CRYBG2 DBN1 PTPRE FGD6 FLACC1

1.51e-041751285daf014e15a354956e9149c83fd89d0af0d07eb00
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-DC2|lymph-node_spleen / Manually curated celltypes from each tissue

SH3D21 DOCK5 ENHO CLIC2 CD74

1.55e-04176128572a3bbab0540ae3e3c94b9573cdb9298a024dbc4
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD141+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

DBN1 SH3D21 PTPRE CLIC2 CD74

1.55e-041761285195393b38f1335f2cb96125616d75c164a6026c2
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYTL2 TNFRSF11A PTPRE GZMH GZMB

1.59e-04177128547813ad05527ea583e736b54b7a48f7ad90c3aef
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNPH PCLO MDM1 HEATR6 ENHO

1.64e-041781285fcbbcc44271515de1969b4732b6441c012693d5f
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SETD1A TSC1 BLM TPX2 SH3RF3

1.68e-041791285b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DLG5 SYTL2 RDH10 CHD2 MUC5B

1.68e-0417912856e965e424eebef50f0202cff75f458be395cfca1
ToppCellnormal_Lymph_Node-Myeloid_cells-CD141+_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

DBN1 DOCK5 PTPRE CLIC2 LTBR

1.68e-041791285ec995ccd6e1dbd06287ad836c232d9aed1cf94a8
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPRN SYTL2 ADCY9 MTMR4 REPS2

1.72e-041801285710526abedc8e0f9ba19ad69220df4c9468ada8f
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 ABI3BP PALMD MAPK11 SH3RF3

1.72e-04180128527e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYTL2 ZEB2 PTPRE GZMH GZMB

1.77e-04181128512ff56fa2949c8d53360cdf2cacfd326e65b54aa
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR22 ZEB2 DOCK5 HEATR6 TPX2

1.77e-0418112853fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

FAT4 ABI3BP GCM1 ZEB2 HIVEP3

1.81e-041821285ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DENND5B AMPD1 ENAM CLEC17A CD74

1.81e-0418212855f1f10c845b73d1f69794277925ef847ff23ac2d
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

WASF3 TNFRSF11A ENHO CLIC2 GZMB

1.81e-041821285ee137574b8f0e684a4a7cb26226877c471cae433
ToppCell(00)_Basal-(0)_uninjured|(00)_Basal / shred by cell type and Timepoint

ABI3BP MUC5B CLIC6 PTPRE IL6ST

1.81e-041821285c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP TNFRSF11A DOCK5 HIVEP3 PTPRE

1.81e-04182128541b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP TNFRSF11A DOCK5 HIVEP3 PTPRE

1.81e-0418212855e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABI3BP TNFRSF11A DOCK5 HIVEP3 PTPRE

1.81e-041821285b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCellCOVID-19_Mild-gd_T|COVID-19_Mild / Disease condition and Cell class

SYTL2 DBN1 ZEB2 GZMH GZMB

1.86e-041831285f593a89b0aa8fffdfa403769916facfd30358521
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_int|lung / Disease (COVID-19 only), tissue and cell type

DENND5B SEC24A DCC BLM ENAM

1.91e-041841285480595a0e2e6aa2a77b7daa36490ae3af3d8dfee
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMPD1 DLG5 ABI3BP RDH10 GPR37L1

1.91e-0418412856b0c110d8930df99043c3b99cf4d873985126960
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

FAT4 ABI3BP ZEB2 APPL1 IL6ST

1.91e-04184128567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMPD1 DLG5 ABI3BP RDH10 GPR37L1

1.91e-04184128535928fc5f7bbf8c7b09181a2bd27e22dff42ec16
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B ANKUB1 AIRE ENAM CD74

1.91e-04184128542cadfdb5d29a50bd7e901ddd14d42b39e8474f0
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

CRYBG2 SYTL2 ZEB2 GZMH GZMB

1.91e-041841285791f1bcb954aadc63d4117c400537d036f68734d
ToppCellLeuk-UTI-Other-RBC|Leuk-UTI / Disease, Lineage and Cell Type

SLC9C2 ENAM PTPRE GZMB CD74

1.96e-0418512855b5dd856d6efc0539d92533cff134bbc3f98be45
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DENND5B AMPD1 SEC24A DCC ENAM

1.96e-0418512853b77bc49cd3740acc025e162a36282ac09e12198
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCLO TNFRSF11A PTPRE XIRP2 CLIC2

1.96e-041851285241ea1e178fffef9e7df971de739e794332d5173
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CHD2 HIVEP3 PTK2B CD74 TP53BP2

1.96e-041851285a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellLeuk-UTI-Other|Leuk-UTI / Disease, Lineage and Cell Type

SLC9C2 ENAM PTPRE GZMB CD74

1.96e-041851285895e8087e97ac0eab3446385e6e0dd24bea7f42c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KIF26B SYTL2 DBN1 GZMH GZMB

2.01e-041861285facc1bd8920003ad03d1893c32fc606d82b4d50a
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

DENND5B SEC24A DCC BLM ENAM

2.01e-04186128566676d9395172de5707e204826a1c9f73b448cca
ToppCellChildren_(3_yrs)-Immune-B_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DENND5B TFEB ENAM CLEC17A CD74

2.01e-041861285aa576748921a318798b911a611f05319b95e8d5e
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYTL2 ZEB2 PTPRE GZMH GZMB

2.01e-041861285c984e5729958237b101df96d1c89a236faacded6
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 ABI3BP PALMD MAPK11 SH3RF3

2.06e-041871285e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TCF20 SLC6A16 WDFY3 FGD6 SH3RF3

2.06e-0418712857e376831a11ee72ed87abcdac631ca46ae29c250
ToppCelldroplet-Spleen-nan-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26B NDC1 KLF1 TJP1 REPS2

2.06e-041871285c81d11d9fdc22dc39222f62c2888025c2e8c3e65
DrugIdoxuridine [54-42-2]; Up 200; 11.2uM; PC3; HT_HG-U133A

FAT4 NLRP1 PALMD PTK2B SETDB1 NF1 SENP6 MAPK11 IL6ST

1.57e-0619412894200_UP
Drugtrifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

BICRA MDM1 NUP214 DBN1 ADCY9 SENP6 APPL1 WDFY3 MAPK11

1.63e-0619512891649_DN
DrugAcebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; MCF7; HT_HG-U133A

DENND5B ABI3BP PCLO NUP214 TNFRSF11A DICER1 NF1 ASCC2 IGSF1

1.85e-0619812894976_DN
DrugH-F-V

ERV3-1 HIVEP3 APPL1 IL6ST

9.28e-06241284CID005288549
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A

ABI3BP BICRA DOCK5 HIVEP3 VPS13D NF1 SENP6 IL6ST

1.44e-0519412883539_DN
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A

ZNF444 CRYBG2 KAT6A HIVEP3 VPS13D WDFY3 MYRF IL6ST

1.55e-0519612883789_DN
DrugMethyldopa (L,-) [555-30-6]; Down 200; 19uM; HL60; HG-U133A

GNL3L RASA1 EP400 SEC24A GRK6 HEATR6 MRPS15 DLAT

1.67e-0519812881619_DN
DrugIodipamide [606-17-7]; Down 200; 3.6uM; MCF7; HT_HG-U133A

SETD1A RBL1 GRK6 SPTLC1 SPART HIVEP3 VPS13D KDM6A

1.73e-0519912886490_DN
DrugTalampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; PC3; HT_HG-U133A

RBL1 SPEG GRK6 MUC5B PALMD ADCY9 KDM6A ABCC10

1.73e-0519912887254_DN
DrugAC1NSKHR

GRK6 NLRP1 MAPK11 MAP2K1

3.88e-05341284CID005311362
DrugNocodazole [31430-18-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A

SPART MUC5B DIS3 VPS13D NF1 PTPRE SENP6

9.54e-0518812872239_UP
DrugEthotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A

GNL3L PCLO MDM1 KAT6A SYTL2 IL6ST MAP3K2

9.54e-0518812874545_DN
DrugMometasone furoate [83919-23-7]; Down 200; 7.6uM; PC3; HT_HG-U133A

SNPH GRK6 MUC5B PALMD HIVEP3 NF1 SENP6

9.54e-0518812875116_DN
DrugMepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A

ZNF444 GNL3L KAT6A DICER1 DOCK5 MAPK11 IL6ST

9.86e-0518912874304_DN
Drugpioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A

DLG5 ZNF444 ABI3BP NLRP1 HP1BP3 DOCK5 FGD6

1.02e-0419012877528_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

ABI3BP KAT6A NBN DICER1 HIVEP3 NF1 IL6ST

1.05e-0419112874279_DN
DrugMetanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; PC3; HT_HG-U133A

MAN2A2 SPART SH3D21 ADCY9 CD74 MYRF MYBPC3

1.09e-0419212876734_UP
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A

DENND5B GNL3L MAN2A2 SYTL2 SPTLC1 NF1 WDFY3

1.12e-0419312873667_DN
DrugGlimepiride [93479-97-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A

SETD1A KAT6A TNFRSF11A DOCK5 NF1 PTPRE IGSF1

1.12e-0419312874973_DN
DrugIopanoic acid [96-83-3]; Down 200; 7uM; MCF7; HT_HG-U133A

DLG5 KAT6A SPART NF1 PTPRE WDFY3 MAPK11

1.16e-0419412875448_DN
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A

MAN2A2 PCLO KAT6A DBN1 NF1 WDFY3 MAPK11

1.16e-0419412874411_DN
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A

SETD1A PCLO NBN VPS13D NF1 KDM6A IL6ST

1.16e-0419412874727_DN
DrugDeferoxamine mesylate [138-14-7]; Down 200; 6uM; PC3; HT_HG-U133A

TFEB ZNF444 GNL3L EP400 SETDB1 MAPK11 IL6ST

1.16e-0419412874317_DN
DrugMefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A

GNL3L SETDB1 VPS13D PTPRE SENP6 FGD6 IL6ST

1.16e-0419412871699_DN
DrugLY-171,883; Down 200; 1uM; MCF7; HG-U133A

SLC6A16 SPART PTK2B VPS13D NF1 KLK2 MYRF

1.16e-041941287222_DN
DrugS(+)-Terguride [37686-84-3]; Up 200; 11.8uM; HL60; HT_HG-U133A

USP53 COL15A1 PCLO SYTL2 SPART NLRP1 NUP214

1.20e-0419512873082_UP
DrugCyclopenthiazide [742-20-1]; Down 200; 10.6uM; PC3; HT_HG-U133A

ZNF444 RBL1 BICRA SETDB1 SENP6 REPS2 KDM6A

1.20e-0419512874229_DN
Drug6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; HL60; HT_HG-U133A

MAN2A2 VPS13D NDC1 NF1 SENP6 KDM6A MAP3K2

1.24e-0419612872511_DN
Drug(S)-propranolol hydrochloride [4199-10-4]; Up 200; 13.6uM; HL60; HT_HG-U133A

DENND5B USP53 NLRP1 DOCK5 PTK2B MYRF IL6ST

1.24e-0419612872961_UP
DrugCephalothin sodium salt [58-71-9]; Up 200; 9.6uM; PC3; HT_HG-U133A

SETD1A FAT4 CRYBG2 MAN2A2 NLRP1 MUC5B ADCY9

1.24e-0419612874482_UP
DrugAminophylline [317-34-0]; Down 200; 9.6uM; PC3; HT_HG-U133A

EP400 GRK6 MDM1 NLRP1 PALMD HIVEP3 MAP3K2

1.24e-0419612876295_DN
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

ZNF444 SPEG PCLO HEATR6 FGD6 MYRF ABCC10

1.24e-0419612877369_DN
DrugBudesonide [51333-22-3]; Down 200; 9.2uM; PC3; HT_HG-U133A

SNPH MAN2A2 BICRA KAT6A SETDB1 WDFY3 KDM6A

1.24e-0419612876330_DN
DrugPrednisone [53-03-2]; Up 200; 11.2uM; HL60; HG-U133A

SEC24A SPTLC1 SPART ZEB2 HP1BP3 SENP6 DLAT

1.24e-0419612871978_UP
DrugKhellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A

DENND5B ZNF444 KAT6A NUP214 DICER1 NF1 MAPK11

1.24e-0419612874987_DN
DrugSalbutamol [18559-94-9]; Up 200; 16.8uM; MCF7; HT_HG-U133A

SLC6A16 SPEG AIRE SPART HIVEP3 CD74 IL6ST

1.24e-0419612872306_UP
DrugSulfamethizole [144-82-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

AMPD1 CRYBG2 PCLO MUC5B PTK2B NF1 CLIC2

1.28e-0419712876099_UP
Drughaloperidol; Up 200; 10uM; HL60; HT_HG-U133A

DLG5 CRYBG2 PCLO AIRE GCM1 NLRP1 DICER1

1.28e-0419712876203_UP
DrugIndoprofen [31842-01-0]; Up 200; 14.2uM; PC3; HT_HG-U133A

AIRE NLRP1 PALMD PTK2B NF1 MAPK11 IL6ST

1.28e-0419712874249_UP
DrugCatechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

APC2 AIRE HP1BP3 PTK2B VPS13D NF1 WDFY3

1.28e-0419712873351_UP
DrugBenfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; PC3; HT_HG-U133A

EP400 RBL1 SPEG SYTL2 PALMD SETDB1 NF1

1.28e-0419712876727_DN
DrugCP-944629 [668990-94-1]; Down 200; 10uM; PC3; HT_HG-U133A

BICRA GRK6 WASF3 SPTLC1 MAPK11 MYRF MYBPC3

1.28e-0419712877502_DN
DrugMyosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A

AMPD1 CRYBG2 SEC24A SPART NUP214 HIVEP3 MYBPC3

1.28e-0419712876055_UP
DrugMephenytoin [50-12-4]; Down 200; 18.4uM; PC3; HT_HG-U133A

ZNF444 SNPH GRK6 HIVEP3 VPS13D PTPRE MAPK11

1.28e-0419712875801_DN
DrugClindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A

GNL3L MAN2A2 HIVEP3 NF1 SENP6 KDM6A IL6ST

1.28e-0419712875815_DN
DrugKetoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A

GNL3L GRK6 KAT6A ADCY9 DOCK5 VPS13D SENP6

1.28e-0419712875685_DN
DrugDihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; MCF7; HT_HG-U133A

TFEB CRYBG2 MAN2A2 SEC24A KAT6A NUP214 DOCK5

1.28e-0419712872237_UP
DrugHyoscyamine (L) [101-31-5]; Up 200; 13.8uM; PC3; HT_HG-U133A

TFEB MAN2A2 GRK6 NUP214 HEATR6 NF1 REPS2

1.28e-0419712875099_UP
DrugLincomycin hydrochloride [859-18-7]; Down 200; 9uM; MCF7; HT_HG-U133A

GNL3L ABI3BP RBL1 SPART TNFRSF11A MAPK11 IL6ST

1.32e-0419812875992_DN
DrugTetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; MCF7; HT_HG-U133A

CRYBG2 NUP214 DIS3 HIVEP3 VPS13D NF1 MAPK11

1.32e-0419812877473_UP
Drugtroglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA

RASA1 EP400 NBN DICER1 ADCY9 VPS13D WDFY3

1.32e-0419812871070_DN
DrugICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A

AMPD1 FAT4 SNPH KIF26B BICRA KLF1 MAPK11

1.32e-0419812875598_UP
DrugOleandomycin phosphate [7060-74-4]; Up 200; 5uM; MCF7; HT_HG-U133A

ZNF444 PCLO SPART DOCK5 HIVEP3 VPS13D IL6ST

1.32e-0419812871518_UP
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; PC3; HT_HG-U133A

EP400 RBL1 PALMD ASCC2 REPS2 KDM6A ABCC10

1.32e-0419812877244_DN
DrugDicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; MCF7; HT_HG-U133A

SETD1A ZNF444 SPART HIVEP3 NF1 KDM6A MAP3K2

1.36e-0419912873307_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 1uM; PC3; HT_HG-U133A

SETD1A ZNF444 SPEG SH3D21 SETDB1 MAPK11 MYRF

1.36e-0419912874561_DN
DrugClemizole hydrochloride [1163-36-6]; Down 200; 11uM; MCF7; HT_HG-U133A

GNL3L TNFRSF11A HP1BP3 DOCK5 NF1 PTPRE IL6ST

1.36e-0419912874695_DN
DrugTorsemide [56211-40-6]; Up 200; 11.4uM; HL60; HT_HG-U133A

USP53 AMPD1 KAT6A SPART NLRP1 DOCK5 KLK2

1.36e-0419912872956_UP
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

DENND5B FAT4 CRYBG2 COL15A1 SPEG HIVEP3 MYBPC3

1.36e-0419912876024_UP
DrugAcetaminophen [103-90-2]; Down 200; 26.4uM; PC3; HT_HG-U133A

MAN2A2 SEC24A NLRP1 PALMD HIVEP3 VPS13D WDFY3

1.40e-0420012876284_DN
DrugSaquinavir mesylate [149845-06-7]; Down 200; 5.2uM; HL60; HT_HG-U133A

DENND5B COL15A1 WASF3 NLRP1 ADCY9 REPS2 IL6ST

1.40e-0420012876127_DN
DrugAzacyclonol [115-46-8]; Down 200; 15uM; PC3; HT_HG-U133A

MAN2A2 RBL1 SPEG GRK6 NLRP1 PALMD DOCK5

1.40e-0420012876298_DN
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A

MAN2A2 ABI3BP SPEG AIRE HP1BP3 WDFY3 IL6ST

1.40e-0420012872224_UP
Drugwortmannin; Up 200; 0.01uM; ssMCF7; HG-U133A

SPART CHD2 RSPH6A DCC SH3D21 CD74 MYRF

1.40e-042001287404_UP
DrugFolinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A

ZNF444 BICRA KAT6A DOCK5 VPS13D IGSF1 KDM6A

1.40e-0420012873442_DN
Drugalpha-ketoisovalerate

KAT6A NUP214 HIVEP3 DLAT MAPK11

1.48e-04891285CID000000049
Drugphenylarsine oxide

RASA1 PTK2B TJP1 LTBR FBXL20 MAPK11 IL6ST MYBPC3

1.68e-042751288CID000004778
Diseasegranzyme b measurement

GZMH GZMB

1.08e-0441262EFO_0020418
DiseaseNoonan Syndrome

RASA1 NF1 MAP2K1

1.44e-04241263C0028326
Diseasecreatinine measurement

DENND5B TFEB AMPD1 KIF26B SPEG GRK6 PRR22 CHD2 DBN1 KIAA1755 FBXL20 REPS2 ABCC10

3.43e-0499512613EFO_0004518
Diseasegrapefruit juice consumption measurement

PCLO DCP1B

3.75e-0471262EFO_0010094
DiseaseLEUKEMIA, ACUTE LYMPHOBLASTIC

NBN NUP214

4.98e-0481262613065
DiseaseAcute lymphoid leukemia

NBN NUP214

4.98e-0481262cv:C0023449
Diseaseresponse to risperidone

TNFRSF11A DOCK5 TJP1

5.75e-04381263GO_0097336
DiseaseMalignant neoplasm of breast

APC2 SPTLC1 NBN NUP214 DBN1 ZEB2 NF1 GZMB CD74 APPL1 REPS2 FLACC1 TP53BP2

7.00e-04107412613C0006142
Diseasemelanoma

FAT4 DCC PTK2B SETDB1 NF1 MAP2K1

7.05e-042481266C0025202
Diseaseglucagon-like peptide-1 measurement

BICRA ENAM

7.96e-04101262EFO_0008465
Diseasespleen volume

TJP1 ASCC2 LTBR

8.28e-04431263EFO_0600047
DiseaseColorectal Carcinoma

AMPD1 SF3A1 APC2 DCC ZEB2 HIVEP3 NF1 TPX2 KDM6A IL6ST

8.84e-0470212610C0009402
DiseaseMedulloblastoma

KAT6A NBN KDM6A

1.29e-03501263C0025149
DiseaseProstatic Neoplasms

COL15A1 WASF3 KAT6A NBN SETDB1 SENP6 KLK2 KDM6A IL6ST

1.35e-036161269C0033578
DiseaseMalignant neoplasm of prostate

COL15A1 WASF3 KAT6A NBN SETDB1 SENP6 KLK2 KDM6A IL6ST

1.35e-036161269C0376358
Diseasealcohol use disorder (implicated_via_orthology)

RASA1 GRK6 CLIC6 CLIC2 KDM6A

1.53e-031951265DOID:1574 (implicated_via_orthology)
Diseaseacute lymphoblastic leukemia (is_implicated_in)

NBN NUP214 KDM6A

1.70e-03551263DOID:9952 (is_implicated_in)
DiseaseNeoplasm of uncertain or unknown behavior of bladder

TSC1 KDM6A

1.83e-03151262C0496930
DiseaseBenign neoplasm of bladder

TSC1 KDM6A

1.83e-03151262C0154017
DiseaseCarcinoma in situ of bladder

TSC1 KDM6A

1.83e-03151262C0154091
DiseaseRASopathy

NF1 MAP2K1

1.83e-03151262cv:C5555857
DiseaseRhabdomyosarcoma

NBN DICER1

1.83e-03151262C0035412
DiseaseMalignant Neoplasms

DICER1 BLM MAP2K1 KDM6A

2.25e-031281264C0006826
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

NBN NUP214 BLM

2.28e-03611263C1961102
DiseaseFamilial Progressive Myoclonic Epilepsy

TSC1 CHD2

2.36e-03171262C0751777
DiseaseAtypical Inclusion-Body Disease

TSC1 CHD2

2.36e-03171262C0751776
DiseaseMyoclonic Epilepsies, Progressive

TSC1 CHD2

2.36e-03171262C0751778
DiseaseBiotin-Responsive Encephalopathy

TSC1 CHD2

2.36e-03171262C0751780
DiseaseMay-White Syndrome

TSC1 CHD2

2.36e-03171262C0751782
DiseaseDentatorubral-Pallidoluysian Atrophy

TSC1 CHD2

2.36e-03171262C0751781
DiseaseCarcinoma of bladder

TSC1 KDM6A

2.65e-03181262C0699885
DiseaseAction Myoclonus-Renal Failure Syndrome

TSC1 CHD2

2.65e-03181262C0751779
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RASA1 MAP2K1

2.95e-03191262C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

RASA1 MAP2K1

2.95e-03191262C1843181
DiseaseCardio-facio-cutaneous syndrome

RASA1 MAP2K1

2.95e-03191262C1275081
DiseaseCostello syndrome (disorder)

RASA1 MAP2K1

2.95e-03191262C0587248
DiseaseDiGeorge syndrome (implicated_via_orthology)

KAT6A DICER1

2.95e-03191262DOID:11198 (implicated_via_orthology)
Diseasecitrulline measurement

KIF26B PTPRE

3.27e-03201262EFO_0009777
Diseaselevel of Phosphatidylcholine (18:1_20:4) in blood serum

DCC MYRF

3.60e-03211262OBA_2045104
DiseaseLEOPARD Syndrome

RASA1 MAP2K1

3.95e-03221262C0175704
Diseaseautism spectrum disorder (implicated_via_orthology)

TCF20 TSC1 CHD2 WDFY3

4.17e-031521264DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KPSSLGKPLPPYIVQ

ACSM6

386

Q6P461
SFYEHVNQKLPEPPP

ERV3-1

256

Q14264
EATPIPEAKLPPVYV

EP400

2271

Q96L91
PPPQKPSHEGSYLLQ

ENHO

61

Q6UWT2
PVRPPQLFKPLYSSH

CXorf66

206

Q5JRM2
KPPPKDNIPALVEEY

ASCC2

41

Q9H1I8
QQFIPVKRPIPHPAY

GZMB

86

P10144
VKRPIPHPAYNPKNF

GZMB

91

P10144
QQFIPVKRPIPHPAY

GZMH

86

P20718
VKRPIPHPAYNPKNF

GZMH

91

P20718
DNPPTFLSPKLTYIP

FAT4

2046

Q6V0I7
EAAVSKDEPKPLPYP

AMPD1

221

P23109
KDEPKPLPYPNLDTF

AMPD1

226

P23109
NKPVFYPKPPKTFAP

C7orf31

236

Q8N865
YPKPPKTFAPNTSLN

C7orf31

241

Q8N865
TAKPIPQIPHFPVYT

DICER1

806

Q9UPY3
LAPPRYPKLGTQHPE

CLIC6

551

Q96NY7
PVPTKPKQINLPYFG

TP53BP2

501

Q13625
TLVYKHLPAPPSAAP

AIRE

391

O43918
YPSPGVLFPKKEPDD

HP1BP3

416

Q5SSJ5
YIVNEPPPKLPSGVF

MAP2K1

316

Q02750
PTKVYKPCGPIQPAT

MUC5B

5361

Q9HC84
VKIPAALPVAAAPYP

RASA1

36

P20936
KQSKVYLPEPPFPHA

INTS9

351

Q9NV88
FSPGNLYIPVFPLPK

ABCC10

941

Q5T3U5
LYIPVFPLPKAAPNG

ABCC10

946

Q5T3U5
IAPHSQVYQPAKPTP

PALMD

466

Q9NP74
AIEPKVPYTPLLSQP

DCC

1356

P43146
PSGPKKYFPIPVEHL

PTPRE

106

P23469
PEPCALPEKPAVYTK

KLK2

231

P20151
TYQEVLSFKPPEPPK

MAPK11

341

Q15759
SGFHLPYKPKPPQET

NOB1

126

Q9ULX3
PLVPAPKNHNYLQPT

FLACC1

41

Q96Q35
YKQPLKPSGSEPPAE

HHLA3

6

Q9XRX5
VDKKPVPEPAYPILF

KIAA1755

131

Q5JYT7
VYTQKGVLPSPAPLP

KIF26B

1091

Q2KJY2
LYVPDPDPTKFPVNR

APPL1

261

Q9UKG1
LPKDKLNPPTPSIYL

KDM6A

931

O15550
NLLPQPPRSKYIHPD

POLD2

116

P49005
YCFADLAPQKPAPPL

POLD2

176

P49005
QLAPSPPKSPKVLYS

PCLO

3611

Q9Y6V0
VPYEKPLPDDISPQK

PCLO

3641

Q9Y6V0
YSLPPHQKVPLPSLS

DLAT

86

P10515
QFVRIHKPPPLTPLY

NLRP1

1271

Q9C000
KGLPVEPPPSYQSVI

MS4A10

216

Q96PG2
QPTNPKLPPHVSDYT

MAP3K2

576

Q9Y2U5
ATLPVSKIPKYPTNP

MDM1

611

Q8TC05
PNTFKRPQTPPKIDY

DLG5

976

Q8TDM6
YPTPLPQYDGRTPIK

HEATR6

286

Q6AI08
PTLQEKKVIPCPPFY

NUP214

221

P35658
ELCAKAPPPVFYNKP

DBN1

611

Q16643
PPSLEYIQAKDLFPP

MTMR4

6

Q9NYA4
PPPLPSSQKDYLSNK

MTMR4

676

Q9NYA4
YKDPDNPGRIALPKP

KAT6A

71

Q92794
YDNPNLIKPIPVKPS

DCP1B

191

Q8IZD4
LYNLKFQPPTLGPEP

APC2

86

O95996
PLPAYPATQKVLQDP

CEFIP

1266

Q711Q0
FYPKPTLLAQPGPVV

IGSF1

871

Q8N6C5
HINFDPVYKVKPNPP

IL6ST

211

P40189
APAPEPKALALQPVY

KLF1

156

Q13351
PPKPINRPFLKPSYA

BLM

1401

P54132
SLPPSYKDKPVPEQI

DOCK5

1436

Q9H7D0
YTLANPLNTPPHIKP

MT-CYB

256

P00156
SIYAPPNNRFKDKPP

GCNT7

256

Q6ZNI0
GEYKQPLPPLHPAVS

CHD2

1771

O14647
KPDQHFKPYLTPDLP

ENPP3

431

O14638
EYPRPIHPAGLQPTK

GPR37L1

66

O60883
PEKSDFPLLAPPTNY

CFAP107

126

Q8N1D5
QSHGPIFSKKYIPPP

CRYBG2

91

Q8N1P7
PFYQQLPLEPPAAKT

GCM1

336

Q9NP62
LYKAVTSQQPPPLPL

DENND5B

211

Q6ZUT9
FLKYEAATVPPPPAA

ADCY9

806

O60503
FLPDGEAKPYVPKEP

MAN2A2

816

P49641
PKEYLPYSLDNPSKP

ENAM

696

Q9NRM1
PLKVYPPLKGSFPEN

CD74

151

P04233
IQAYKPDDLKSPPFP

CCDC168

6371

Q8NDH2
KYRPPPQTNLLAPKL

PTK2B

721

Q14289
LEPPFKPDPQAIYCK

GRK6

461

P43250
IQPKPAGVLPPKLYQ

BICRA

351

Q9NZM4
AGVLPPKLYQLTPKP

BICRA

356

Q9NZM4
PKLYQLTPKPFAPAG

BICRA

361

Q9NZM4
LLPPPNPISSANYEK

COL15A1

1201

P39059
PYSKIPIFPLFPNVD

EFCAB3

236

Q8N7B9
ITYPPQKADAPAVSP

C3orf86

26

P0DN24
YPTDFLGPLPANPVK

DPP7

276

Q9UHL4
EQTLAPPRYPHLSPK

CLIC2

91

O15247
QPVYLPSKDGPKAPT

NUTM2F

326

A1L443
QPVYLPSKDGPKAPT

NUTM2G

326

Q5VZR2
DPPPSTLLKDYQNVP

MRPS15

66

P82914
KYSPESFNPALPAPI

RSPH6A

651

Q9H0K4
LQYVPEPVPGKKLPT

SYTL2

776

Q9HCH5
NPAFLKFHPYPPSVL

SPATA48

61

A4D263
SPPPVPGEVLKVQSY

TFEB

61

P19484
PDAKPPVNLLYNPTS

SLC6A16

426

Q9GZN6
FPDNFVLPPPPIKKL

SH3D21

116

A4FU49
PYPPLQEAGSIPVTK

SH3D19

86

Q5HYK7
TQSPGKYVLPPPKLN

TMEM185A

331

Q8NFB2
SKKQPPQIESFYPPL

NBN

186

O60934
IFQNPYEEPPKLPRS

RBL1

146

P28749
GSYPHPIPAKTLNPV

SEC24A

56

O95486
NIKVHAYFAPVTPPP

FBXL20

406

Q96IG2
KISFYIPPPATHTLP

GNL3L

396

Q9NVN8
GIKPPTPEQYLTPLQ

SNPH

66

O15079
KASKPLPPAPAPDEY

SF3A1

396

Q15459
EPFLPPLKPDYCVKQ

RDH10

261

Q8IZV5
HPAPPPSNYEILVKA

DIS3

691

Q9Y2L1
NYALAVKPTPPAPAL

SETD1A

1301

O15047
PPVPKDHPALNYNIV

SPTLC1

71

O15269
PPPQVAYSKERIPGK

SETDB1

701

Q15047
IKNTYLPQVPLPPVS

ANKUB1

441

A6NFN9
DYENSTPPYKDLPPK

CLEC17A

51

Q6ZS10
FCQNLPPPLPPKKYA

USP53

916

Q70EK8
LSQSPKKDSYVEPPP

XIRP2

2966

A4UGR9
LNLYHPPDPEKEVFP

PRR22

46

Q8IZ63
DLQEVPKLYPEFPPK

SPART

106

Q8N0X7
PPPYDHLFEVALPKT

TSC1

601

Q92574
QAVRPYKQEPSSPPL

ZNF444

151

Q8N0Y2
VSTPPVYPPKNVADL

WDFY3

816

Q8IZQ1
PPTLQPEYLQAAFPK

REPS2

361

Q8NFH8
RVPGKLAPPEVPQTY

SPEG

2676

Q15772
EPKQLPEKYSLPASP

RINT1

286

Q6NUQ1
IQPLPHAPPQGKALY

SH3RF3

251

Q8TEJ3
KEFYRPIPNPNPKLT

TEX37

51

Q96LM6
PPPLNILTPYRDDKK

WASF3

131

Q9UPY6
LEIHLVPYTPKFPTP

FGD6

301

Q6ZV73
KPYLPPPVSLFSFQH

HIVEP3

1136

Q5T1R4
PYEAGILDKKPPPRI

NF1

1421

P21359
IFIGPVEKLIVYPPP

SENP6

646

Q9GZR1
NEIFPKPPLYTFLPD

ZNF518A

1086

Q6AHZ1
PQDYAATLPKNPPPK

TCF20

1726

Q9UGU0
LYKKPPPFLELLPSP

nan

541

Q6ZUG5
SLPTHYQPEPAKAFP

ZNF469

656

Q96JG9
QKTVPSDPPYPSFLL

ZNF469

1461

Q96JG9
PKAHPYFPDLVQPLL

LTBR

281

P36941
PALPPKIFYIKQEPF

ZBTB9

276

Q96C00
EKQTPSLPEPKPVYA

TJP1

376

Q07157
APQAAKLPYLPHPAR

TPRN

466

Q4KMQ1
PKAIPPPTPDIYLHN

SLC9C2

851

Q5TAH2
AKPLYTALPPQSAFP

ZEB2

891

O60315
KYLIVVRPAPPPSQK

ABI3BP

91

Q7Z7G0
LLPHKPYPEVSQSEP

ABI3BP

581

Q7Z7G0
RKPPNEPHVYLPGLI

TNFRSF11A

201

Q9Y6Q6
YCPIIPNKSPSKGPL

PP2D1

481

A8MPX8
IKAQPVPHYGVPFKP

TPX2

511

Q9ULW0
KEVQDKDYPLTPPPS

VPS13D

1751

Q5THJ4
PRPGITYEPPNYKAL

MYBPC3

1161

Q14896
PIKAEPKAPYAPGTL

MYRF

121

Q9Y2G1
PKVLNSNPPPIIKYL

NDC1

316

Q9BTX1