Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranslation activator activity

DAZ4 DAZ1 DAZ3 DAZ2

6.87e-0815554GO:0008494
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A

8.02e-077585512GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A

1.29e-067935512GO:0015075
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A SLC19A3 NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A SLC22A12

2.60e-0611805514GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A1 SLC6A18 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 TMEM87A

4.58e-06465559GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A1 SLC6A18 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A

7.09e-066275510GO:0022890
GeneOntologyMolecularFunctiontransporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A SLC19A3 NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A SLC22A12

7.24e-0612895514GO:0005215
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A1 SLC6A18 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L TMEM87A

1.17e-056645510GO:0008324
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A1 SLC6A18 SCN4A SLC5A9 GRIK3

1.07e-04171555GO:0015081
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

DAZ4 DAZ1 DAZ3 DAZ2

2.57e-04112554GO:0090079
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7

3.90e-04125554GO:0015108
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7

7.94e-04151554GO:0008509
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A1 SLC6A18

9.87e-0417552GO:0015378
GeneOntologyMolecularFunctionmagnesium ion transmembrane transporter activity

NIPAL1 NIPA2

1.11e-0318552GO:0015095
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A1 SLC6A18

1.24e-0319552GO:0015373
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7

1.26e-03171554GO:0015103
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A1 SLC6A18 CLCN3 SLC26A7 SLC5A9

1.31e-03296555GO:0015291
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A1 SLC6A18 SLC5A9

1.45e-0381553GO:0015370
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CLCN3 SLC26A7 PKD1L1 SCN4A GRIK3 TMEM87A

1.60e-03459556GO:0005216
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A1 SLC6A18

1.82e-0323552GO:0015377
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A1 SLC6A18

1.82e-0323552GO:0005283
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A1 SLC6A18

2.32e-0326552GO:0015296
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC6A1 SLC26A7 SLC19A3 GRIK3

2.53e-03207554GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC6A1 SLC26A7 SLC19A3 GRIK3

2.58e-03208554GO:0005342
GeneOntologyMolecularFunctionintramolecular transferase activity

PGM2L1 LSS

2.88e-0329552GO:0016866
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A1 SLC6A18

2.88e-0329552GO:0005416
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A1 SLC6A18 GRIK3

3.04e-03105553GO:0015171
GeneOntologyMolecularFunctionchannel activity

CLCN3 SLC26A7 PKD1L1 SCN4A GRIK3 TMEM87A

3.13e-03525556GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CLCN3 SLC26A7 PKD1L1 SCN4A GRIK3 TMEM87A

3.15e-03526556GO:0022803
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A1 SLC6A18 SLC5A9

4.32e-03119553GO:0015294
GeneOntologyMolecularFunctionmRNA 3'-UTR binding

DAZ4 DAZ1 DAZ3 DAZ2

7.01e-03276554GO:0003730
GeneOntologyMolecularFunctionsymporter activity

SLC6A1 SLC6A18 SLC5A9

8.19e-03150553GO:0015293
GeneOntologyBiologicalProcessfemale meiosis II

DAZ4 DAZ1 DAZ3 DAZ2

6.76e-106554GO:0007147
GeneOntologyBiologicalProcessmeiosis II

DAZ4 DAZ1 DAZ3 DAZ2

6.76e-106554GO:0007135
GeneOntologyBiologicalProcessmeiosis II cell cycle process

DAZ4 DAZ1 DAZ3 DAZ2

6.76e-106554GO:0061983
GeneOntologyBiologicalProcesspositive regulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

6.47e-0726554GO:0045836
GeneOntologyBiologicalProcesspositive regulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

1.02e-0629554GO:0045948
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-0631554GO:0070935
GeneOntologyBiologicalProcesspositive regulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

2.80e-0637554GO:0051446
GeneOntologyBiologicalProcessregulation of meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

6.21e-0645554GO:0040020
GeneOntologyBiologicalProcessoocyte maturation

DAZ4 DAZ1 DAZ3 DAZ2

7.41e-0647554GO:0001556
GeneOntologyBiologicalProcessfemale meiotic nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

1.11e-0552554GO:0007143
GeneOntologyBiologicalProcesspositive regulation of nuclear division

DAZ4 DAZ1 DAZ3 DAZ2

4.78e-0575554GO:0051785
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 ACE DMAC2L SLC22A12

5.00e-0513745513GO:0006811
GeneOntologyBiologicalProcessmRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

5.30e-0577554GO:0048255
GeneOntologyBiologicalProcessregulation of meiotic cell cycle

DAZ4 DAZ1 DAZ3 DAZ2

6.78e-0582554GO:0051445
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

8.55e-0587554GO:1902373
GeneOntologyBiologicalProcessRNA stabilization

DAZ4 DAZ1 DAZ3 DAZ2

8.93e-0588554GO:0043489
GeneOntologyBiologicalProcessregulation of nuclear division

DAZ4 PRMT5 DAZ1 DAZ3 DAZ2

9.45e-05172555GO:0051783
GeneOntologyBiologicalProcessregulation of translational initiation

DAZ4 DAZ1 DAZ3 DAZ2

1.02e-0491554GO:0006446
GeneOntologyBiologicalProcessoocyte development

DAZ4 DAZ1 DAZ3 DAZ2

1.41e-0499554GO:0048599
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 GRIK3 DMAC2L

1.46e-0411155511GO:0034220
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

DAZ4 DAZ1 DAZ3 DAZ2

1.52e-04101554GO:1902369
GeneOntologyBiologicalProcessdevelopmental maturation

SHANK1 GHRHR CLCN3 DAZ4 DAZ1 DAZ3 DAZ2

1.58e-04439557GO:0021700
GeneOntologyBiologicalProcessoocyte differentiation

DAZ4 DAZ1 DAZ3 DAZ2

1.64e-04103554GO:0009994
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

DAZ4 DAZ1 DAZ3 DAZ2

2.51e-04115554GO:1903312
GeneOntologyBiologicalProcesspositive regulation of reproductive process

DAZ4 DAZ1 DAZ3 DAZ2

2.77e-04118554GO:2000243
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A1 SLC6A18 CLCN3 SLC26A7 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 DMAC2L

3.14e-0410175510GO:0098660
GeneOntologyBiologicalProcesstranslational initiation

DAZ4 DAZ1 DAZ3 DAZ2

4.25e-04132554GO:0006413
GeneOntologyBiologicalProcesspostsynaptic density organization

SHANK1 NRXN3 LRRC4B

4.99e-0458553GO:0097106
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A1 SLC6A18 CLCN3 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 DMAC2L

6.84e-04922559GO:0098662
GeneOntologyBiologicalProcesspositive regulation of translation

DAZ4 DAZ1 DAZ3 DAZ2

7.04e-04151554GO:0045727
GeneOntologyBiologicalProcesscell maturation

GHRHR DAZ4 DAZ1 DAZ3 DAZ2

7.18e-04267555GO:0048469
GeneOntologyBiologicalProcessoogenesis

DAZ4 DAZ1 DAZ3 DAZ2

7.96e-04156554GO:0048477
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A1 SLC6A18 CLCN3 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 DMAC2L

7.97e-04942559GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A1 SLC6A18 CLCN3 PKD1L1 SCN4A NIPAL1 SLC5A9 NIPA2 ACE DMAC2L

8.62e-0411575510GO:0006812
GeneOntologyBiologicalProcesspostsynaptic specialization organization

SHANK1 NRXN3 LRRC4B

9.02e-0471553GO:0099084
GeneOntologyBiologicalProcessmagnesium ion transmembrane transport

NIPAL1 NIPA2

1.04e-0318552GO:1903830
GeneOntologyBiologicalProcessmagnesium ion transport

NIPAL1 NIPA2

1.16e-0319552GO:0015693
HumanPhenoY-linked inheritance

DAZ1 KDM5D DAZ3 DAZ2

7.68e-0718224HP:0001450
MousePhenoabsent ovarian follicles

MCPH1 DAZ4 DAZ1 DAZ3 DAZ2

5.78e-0751455MP:0002777
DomainGPR107-like

TMEM87B TMEM87A

5.28e-054562IPR009637
DomainLung_7-TM_R

TMEM87B TMEM87A

5.28e-054562PF06814
DomainMg_trans_NIPA

NIPAL1 NIPA2

1.31e-046562IPR008521
DomainMg_trans_NIPA

NIPAL1 NIPA2

1.31e-046562PF05653
DomainLH2

PKD1L1 ALOX12B

1.31e-0318562SM00308
DomainNA_NEUROTRAN_SYMP_2

SLC6A1 SLC6A18

1.31e-0318562PS00754
DomainSNF

SLC6A1 SLC6A18

1.46e-0319562PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A1 SLC6A18

1.46e-0319562PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A1 SLC6A18

1.46e-0319562PS50267
DomainNa/ntran_symport

SLC6A1 SLC6A18

1.46e-0319562IPR000175
DomainIG

IGSF10 CD300LF LRRC24 CD300LB LRRC4B CD300E

1.59e-03421566SM00409
DomainIg_sub

IGSF10 CD300LF LRRC24 CD300LB LRRC4B CD300E

1.59e-03421566IPR003599
DomainPLAT

PKD1L1 ALOX12B

1.79e-0321562PS50095
Domain-

PKD1L1 ALOX12B

1.79e-03215622.60.60.20
DomainPLAT

PKD1L1 ALOX12B

1.79e-0321562PF01477
DomainPLAT/LH2_dom

PKD1L1 ALOX12B

1.79e-0321562IPR001024
DomainCys-rich_flank_reg_C

IGSF10 LRRC24 LRRC4B

2.49e-0390563IPR000483
DomainLRRCT

IGSF10 LRRC24 LRRC4B

2.49e-0390563SM00082
DomainIg_V-set

IGSF10 CD300LF CD300LB CD300E

2.98e-03199564IPR013106
DomainLRRNT

IGSF10 LRRC24 LRRC4B

3.17e-0398563IPR000372
DomainLRRNT

IGSF10 LRRC24 LRRC4B

3.17e-0398563SM00013
DomainIG_LIKE

IGSF10 CD300LF LRRC24 CD300LB LRRC4B CD300E

3.42e-03491566PS50835
DomainRRM_1

DAZ4 DAZ1 DAZ3 DAZ2

3.49e-03208564PF00076
DomainIg-like_dom

IGSF10 CD300LF LRRC24 CD300LB LRRC4B CD300E

3.85e-03503566IPR007110
DomainRRM

DAZ4 DAZ1 DAZ3 DAZ2

4.06e-03217564SM00360
DomainRRM_dom

DAZ4 DAZ1 DAZ3 DAZ2

4.76e-03227564IPR000504
DomainRRM

DAZ4 DAZ1 DAZ3 DAZ2

4.99e-03230564PS50102
Domain-

DAZ4 DAZ1 DAZ3 DAZ2

6.13e-032445643.30.70.330
PathwayWP_OVARIAN_INFERTILITY

DAZ4 DAZ1 DAZ3 DAZ2

5.26e-0635474MM15948
Pubmed

Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457415066457
Pubmed

Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-1245747670487
Pubmed

Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457411694340
Pubmed

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-1245749321470
Pubmed

Polymorphic expression of DAZ proteins in the human testis.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457419223287
Pubmed

Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457411095434
Pubmed

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457426232607
Pubmed

[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457411688365
Pubmed

Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457412752250
Pubmed

A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457411883873
Pubmed

Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457410936047
Pubmed

[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457416963411
Pubmed

Partial DAZ deletions in a family with five infertile brothers.

DAZ4 DAZ1 DAZ3 DAZ2

6.48e-12457412801575
Pubmed

PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

DAZ4 PRMT5 DAZ1 DAZ3 DAZ2

1.96e-111457525457166
Pubmed

Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557423579190
Pubmed

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557422021443
Pubmed

The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155749288969
Pubmed

The dazzle in germ cell differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557420008336
Pubmed

Co-culture of spermatogonial stem cells with sertoli cells in the presence of testosterone and FSH improved differentiation via up-regulation of post meiotic genes.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557423456578
Pubmed

Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748679003
Pubmed

In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557410903443
Pubmed

Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155749143498
Pubmed

Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557422699882
Pubmed

A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748845845
Pubmed

DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557411058556
Pubmed

AZFc partial deletions in Chilean men with severe spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557417416365
Pubmed

Dazl promotes germ cell differentiation from embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557419783541
Pubmed

Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557422293198
Pubmed

DAZL protein expression in mouse preimplantation embryo.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557417761180
Pubmed

Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557419468308
Pubmed

Partial rescue of the Dazl knockout mouse by the human DAZL gene.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557412200456
Pubmed

Nature of the spermatogenic arrest in Dazl -/- mice.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557411514340
Pubmed

Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557411089564
Pubmed

Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557423298641
Pubmed

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557422223682
Pubmed

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557410393944
Pubmed

The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748968756
Pubmed

A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748968755
Pubmed

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557430380414
Pubmed

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557426411291
Pubmed

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557423223451
Pubmed

Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557434985827
Pubmed

Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557411804965
Pubmed

Expression profiling of the developing testis in wild-type and Dazl knockout mice.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557414648873
Pubmed

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748896558
Pubmed

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155749700189
Pubmed

Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-11557421270429
Pubmed

Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-1155748661148
Pubmed

Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657415066460
Pubmed

DAZL binds to the transcripts of several Tssk genes in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657418452650
Pubmed

A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657424086306
Pubmed

DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657419247806
Pubmed

DAZL is a master translational regulator of murine spermatogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657431355046
Pubmed

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657423417416
Pubmed

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657432170089
Pubmed

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657416278232
Pubmed

Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657420157580
Pubmed

A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657417219433
Pubmed

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657428496037
Pubmed

DAZL regulates Tet1 translation in murine embryonic stem cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657426077710
Pubmed

The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657416001084
Pubmed

Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657432962040
Pubmed

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657417526644
Pubmed

Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-1165741869307
Pubmed

A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657411390979
Pubmed

BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657427632217
Pubmed

The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-1165741638086
Pubmed

Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

9.70e-11657414611632
Pubmed

Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757410857750
Pubmed

The RNA-binding specificity of the mouse Dazl protein.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757411410654
Pubmed

Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757415081113
Pubmed

Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757422699423
Pubmed

Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757411604102
Pubmed

The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-1075749588208
Pubmed

DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757426826184
Pubmed

Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

DAZ4 DAZ1 DAZ3 DAZ2

2.26e-10757416946704
Pubmed

Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857410951504
Pubmed

Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857432339196
Pubmed

Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857433749946
Pubmed

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857423204224
Pubmed

Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857429883445
Pubmed

A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857410823932
Pubmed

Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857422621333
Pubmed

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857432686646
Pubmed

A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.

DAZ4 DAZ1 DAZ3 DAZ2

4.51e-10857411869379
Pubmed

Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.

DAZ4 DAZ1 DAZ3 DAZ2

8.12e-10957416310179
Pubmed

Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

8.12e-10957420159962
Pubmed

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.

DAZ4 DAZ1 DAZ3 DAZ2

8.12e-10957426378784
Pubmed

Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.

DAZ4 DAZ1 DAZ3 DAZ2

8.12e-10957419695304
Pubmed

The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

8.12e-10957428235998
Pubmed

Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development.

DAZ4 PRMT5 DAZ1 DAZ3 DAZ2

9.43e-102857525810472
Pubmed

Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057410601091
Pubmed

Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057431234534
Pubmed

Tesmin transcription is regulated differently during male and female meiosis.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057414648882
Pubmed

MAX controls meiotic entry in sexually undifferentiated germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057438433229
Pubmed

Knockout mouse model and gametogenic failure.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-09105749922113
Pubmed

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057423810942
Pubmed

The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.

DAZ4 DAZ1 DAZ3 DAZ2

1.35e-091057412837688
Pubmed

NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells.

DAZ4 DAZ1 DAZ3 DAZ2

2.12e-091157434401671
Pubmed

ZGLP1 is a determinant for the oogenic fate in mice.

DAZ4 DAZ1 DAZ3 DAZ2

3.18e-091257432054698
CytobandYq11.223

DAZ4 DAZ1 DAZ3 DAZ2

5.74e-0693574Yq11.223
CytobandEnsembl 112 genes in cytogenetic band chrYq11

DAZ4 DAZ1 KDM5D DAZ3 DAZ2

4.33e-05311575chrYq11
Cytoband17q25.1

CD300LF CD300LB CD300E

1.45e-048157317q25.1
Cytoband3q13.33

POPDC2 POLQ

6.44e-04305723q13.33
Cytoband17q23.3

SCN4A ACE

6.44e-043057217q23.3
Cytoband3p25.3

SLC6A1 LINC00312

1.45e-03455723p25.3
CytobandEnsembl 112 genes in cytogenetic band chr3q13

PLA1A POPDC2 POLQ

2.66e-03221573chr3q13
GeneFamilySolute carriers

SLC6A1 SLC6A18 SLC26A7 SLC19A3 SLC5A9 SLC22A12

2.14e-04395406752
GeneFamilyRNA binding motif containing

DAZ4 DAZ1 DAZ3 DAZ2

1.23e-03213404725
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

CD163L1 LY75

1.62e-03274021253
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IGSF10 LRRC24 LRRC4B

5.38e-03161403593
GeneFamilyAdenosine receptors|V-set domain containing

CD300LF CD300LB CD300E

5.57e-03163403590
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

KDM5D LY75

5.68e-0351402870
GeneFamilySterile alpha motif domain containing

SHANK1 SGMS1

1.62e-0288402760
CoexpressionTESAR_JAK_TARGETS_MOUSE_ES_D3_DN

DAZ4 DAZ1 DAZ3 DAZ2

8.48e-0912554MM742
CoexpressionSASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN

DAZ4 DAZ1 DAZ3 DAZ2

8.48e-0912554MM781
CoexpressionWAGSCHAL_EHMT2_TARGETS_UP

DAZ4 DAZ1 DAZ3 DAZ2

1.49e-0723554MM1293
CoexpressionMATZUK_SPERMATOGONIA

DAZ4 DAZ1 DAZ3 DAZ2

5.23e-0731554MM765
CoexpressionCHEN_ETV5_TARGETS_TESTIS

DAZ4 DAZ1 DAZ3 DAZ2

6.78e-0733554MM701
CoexpressionMADAN_DPPA4_TARGETS

DAZ4 DAZ1 DAZ3 DAZ2

3.24e-0586554MM1312
CoexpressionJACKSON_DNMT1_TARGETS_UP

DAZ4 DAZ1 DAZ3 DAZ2

4.41e-0593554MM1185
Drugboron trichloride

DAZ4 DAZ1 DAZ3 DAZ2

5.27e-106574CID000025135
DrugAZFd

DAZ4 DAZ1 KDM5D DAZ3 DAZ2

2.67e-0923575CID000196489
Drugd-gluconhydroximo-1,5-lactam

MAN2A1 DAZ4 DAZ1 DAZ3 DAZ2

1.33e-0831575CID000003479
Drugdesmethylazelastine

DAZ4 DAZ1 DAZ3 DAZ2

6.28e-0816574CID000162558
Drugmolybdenum disulfide

PLA1A DAZ4 DAZ1 DAZ3 DAZ2

7.36e-0843575CID000014823
Drug2-chlorodideoxyadenosine

DAZ4 DAZ1 KDM5D DAZ3 DAZ2

7.36e-0843575CID000072194
Drugpropham

SGMS1 DAZ4 DAZ1 DAZ3 DAZ2

8.28e-0844575CID000024685
Drugdazmegrel

DAZ4 DAZ1 DAZ3 DAZ2

1.33e-0719574CID000053555
DrugYM 026

DAZ4 DAZ1 DAZ3 DAZ2

1.33e-0719574CID000004443
Drugdansylaziridine

DAZ4 DAZ1 DAZ3 DAZ2

3.02e-0723574CID000104008
Drugazafagomine

DAZ4 DAZ1 KDM5D DAZ3 DAZ2

3.12e-0757575CID011957435
Drugcarbonyl sulfide

SGMS1 DAZ4 DAZ1 KDM5D DAZ3 DAZ2

4.51e-07116576CID000010039
Drugazelastine

DAZ4 DAZ1 DAZ3 DAZ2 ALOX12B

1.16e-0674575CID000002267
Drugp11-13

DAZ4 DAZ1 KDM5D DAZ3 DAZ2

1.24e-0675575CID000015759
DrugVistar

DAZ4 DAZ1 DAZ3 DAZ2

1.96e-0636574CID000040896
Drug3-bromo-7-nitroindazole

DAZ4 DAZ1 DAZ3 DAZ2

1.96e-0636574CID000001649
DrugBW755C

DAZ4 DAZ1 DAZ3 DAZ2 ALOX12B

3.61e-0693575CID000047795
Drugbipy

DAZ4 LSS DAZ1 DAZ3 DAZ2

4.44e-0697575CID000001474
Drugridogrel

DAZ4 DAZ1 DAZ3 DAZ2

8.74e-0652574CID005362391
DrugTXB2 (thromboxane B2

DAZ4 DAZ1 DAZ3 DAZ2 ALOX12B

1.16e-05118575CID000005461
DrugNSC56408

DAZ4 DAZ1 DAZ3 DAZ2

1.77e-0562574CID000005604
Drugthromboxane

DAZ4 DAZ1 DAZ3 DAZ2 ACE ALOX12B

1.97e-05223576CID000114873
Drugkt S

DAZ4 DAZ1 DAZ3 DAZ2

2.27e-0566574CID006399216
Drugfluorocyclobutane

SCN4A GRIK3

1.28e-047572CID011051569
DiseaseMale sterility due to Y-chromosome deletions

DAZ4 DAZ1 DAZ3 DAZ2

6.46e-108534C2931163
DiseasePartial chromosome Y deletion

DAZ4 DAZ1 DAZ3 DAZ2

6.46e-108534C1507149
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

DAZ1 KDM5D DAZ3 DAZ2

1.66e-0816534C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

DAZ1 KDM5D DAZ3 DAZ2

1.66e-0816534415000
DiseaseSpermatogenic failure, Y-linked, 2

DAZ1 KDM5D DAZ3 DAZ2

1.66e-0816534cv:C1839071
DiseaseCoronary heart disease

ACE DNAH11

8.52e-0424532C0010068
DiseaseAlcoholic Intoxication, Chronic

SLC6A1 NRXN3 GRIK3 ACE

1.37e-03268534C0001973

Protein segments in the cluster

PeptideGeneStartEntry
YWWKNCKMWAIGITV

VAMP3

71

Q15836
WVKTASGWALALCRW

AAAS

106

Q9NRG9
SGLWWTLALFCWISD

ACER2

181

Q5QJU3
TSRKYEDLLWAWEGW

ACE

776

P12821
SYWCKIQTVWVLDSW

CD300E

101

Q496F6
TWLTWQDDCWGYIER

DNAH11

801

Q96DT5
LWSQYWTLLWAACAQ

CCDC142

301

Q17RM4
GGEASLWDCIRWEWK

CD163L1

761

Q9NR16
KLPWSCDSRYFWGWL

DMAC2L

31

Q99766
WTEAYKWWYLVCLIQ

DAZ2

541

Q13117
RNLWTEAYKWWYLVC

DAZ3

466

Q9NR90
WKPQTWDYGWSYCLA

GSG1L2

196

A8MUP6
LGWRDKATWLFSWLD

DNAJC14

356

Q6Y2X3
IARGCWVLSYDWVLW

MCPH1

701

Q8NEM0
WVLSYDWVLWSLELG

MCPH1

706

Q8NEM0
FIWSEISYLSKWWDI

MAN2A1

211

Q16706
WVGLRKINVSYWCWE

ATRN

856

O75882
SSPLLAWWEWDTKFL

KDM5D

1216

Q9BY66
GSFLIWLLLCWNSWY

LINC00312

36

Q9Y6C7
WLLLCWNSWYHLRTL

LINC00312

41

Q9Y6C7
ELAALFGWWMFDCWK

PGM2L1

356

Q6PCE3
SWGKFWLAVLNVYSW

LSS

191

P48449
HAYLKEWLWWAGLLS

NIPA2

51

Q8N8Q9
WRCDCALHWLGAWIK

LRRC24

206

Q50LG9
WIGLRWTAYEKINKW

LY75

1011

O60449
LLQWYLRLKSWWASN

CPT1C

216

Q8TCG5
LRLKSWWASNYVSDW

CPT1C

221

Q8TCG5
WTCDCHLKWLSDWIQ

IGSF10

221

Q6WRI0
LWTEAYKWWYLVCLI

DAZ1

726

Q9NQZ3
WETYLKWWCRGAIWR

CD300LF

46

Q8TDQ1
WTTIDWYRFFCLWEK

POLQ

661

O75417
RFWRCSNSKKVWYEW

PRMT5

601

O14744
ACWDLDDTSPYWWII

GHRHR

271

Q02643
WDWLLAKTWVRYAEF

ALOX12B

376

O75342
WNKSLEWSPWNCILL

IQUB

701

Q8NA54
LWTEAYKWWYLVCLI

DAZ4

561

Q86SG3
LVWEYWAGLLVCAFW

GRIK3

11

Q13003
LCFLYSWWLAESARW

SLC22A12

271

Q96S37
ECYSSKRLFYWSLWW

SLC19A3

271

Q9BZV2
DWWDWSLTTLLDGLY

PKD1L1

2336

Q8TDX9
YLKEWLWWVGLLSMG

NIPAL1

111

Q6NVV3
NCDVLWLSWWLKETV

LRRC4B

316

Q9NT99
AWILVYFCIWKGVGW

SLC6A1

221

P30531
PWWYKCAHKVLIWNC

SCN4A

546

P35499
AWTLGIWFLFWGCIV

NRXN3

16

Q9HDB5
WALSTWEKLGKLYWL

SIRT4

126

Q9Y6E7
RSWGKLLWSWFCGLS

SLC5A9

616

Q2M3M2
QLKSCIVWSWTYLWT

ST7

11

Q9NRC1
VYWRLWGTINWLTCS

SANBR

386

Q6NSI8
WWLLICLAASWAVVY

SLC6A18

181

Q96N87
GFWTKFDVADWLEWL

SHANK1

2096

Q9Y566
GWETYIKWWCRGVRW

CD300LB

41

A8K4G0
WEMTKSLYDAWSGWL

CLCN3

116

P51790
WESCFWVGGLILWLS

PLA1A

6

Q53H76
WYHWICWLLSVVGIF

SGMS1

306

Q86VZ5
LWGWFSACGLDIVLW

POPDC2

66

Q9HBU9
LSSKSGFWTIWLWNK

TRIM21

371

P19474
GILWLTWSACYWKDI

TMEM87B

231

Q96K49
WNVDKIDWGIWVSTY

SLC26A7

431

Q8TE54
GVLWLAWSACYWRDL

TMEM87A

241

Q8NBN3