Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	recombination hotspot binding	PRDM9 PRDM7	1.88e-05	2	87	2	GO:0010844
GeneOntologyMolecularFunction	cytoskeleton-nuclear membrane anchor activity	SUN2 SUN1	1.86e-04	5	87	2	GO:0140444
GeneOntologyBiologicalProcess	cerebral cortex radial glia-guided migration	DAB2IP RELN SUN2 SUN1 LAMB1	1.65e-07	30	88	5	GO:0021801
GeneOntologyBiologicalProcess	telencephalon glial cell migration	DAB2IP RELN SUN2 SUN1 LAMB1	1.65e-07	30	88	5	GO:0022030
GeneOntologyBiologicalProcess	forebrain cell migration	DAB2IP RELN AXL SUN2 SUN1 LAMB1	8.07e-07	75	88	6	GO:0021885
GeneOntologyBiologicalProcess	cerebral cortex radially oriented cell migration	DAB2IP RELN SUN2 SUN1 LAMB1	9.47e-07	42	88	5	GO:0021799
GeneOntologyBiologicalProcess	cell motility involved in cerebral cortex radial glia guided migration	DAB2IP SUN2 SUN1	2.59e-06	7	88	3	GO:0021814
GeneOntologyBiologicalProcess	cerebral cortex cell migration	DAB2IP RELN SUN2 SUN1 LAMB1	4.06e-06	56	88	5	GO:0021795
GeneOntologyBiologicalProcess	telencephalon cell migration	DAB2IP RELN SUN2 SUN1 LAMB1	1.41e-05	72	88	5	GO:0022029
GeneOntologyBiologicalProcess	glial cell migration	DAB2IP RELN SUN2 SUN1 LAMB1	2.36e-05	80	88	5	GO:0008347
GeneOntologyBiologicalProcess	negative regulation of vascular endothelial growth factor receptor signaling pathway	DAB2IP NIBAN2 EPN2	2.64e-05	14	88	3	GO:0030948
GeneOntologyBiologicalProcess	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	SUN2 SUN1	5.38e-05	3	88	2	GO:0021817
GeneOntologyBiologicalProcess	negative regulation of NAD(P)H oxidase activity	INS INS-IGF2	5.38e-05	3	88	2	GO:0033861
GeneOntologyBiologicalProcess	nuclear matrix anchoring at nuclear membrane	SUN2 SUN1	5.38e-05	3	88	2	GO:0090292
GeneOntologyBiologicalProcess	negative regulation of glycogen catabolic process	INS INS-IGF2	1.07e-04	4	88	2	GO:0045818
GeneOntologyBiologicalProcess	nuclear matrix organization	SUN2 SUN1	1.07e-04	4	88	2	GO:0043578
GeneOntologyBiologicalProcess	positive regulation of reciprocal meiotic recombination	PRDM9 PRDM7	1.07e-04	4	88	2	GO:0010845
GeneOntologyBiologicalProcess	positive regulation of nitric oxide mediated signal transduction	INS INS-IGF2	1.07e-04	4	88	2	GO:0010750
GeneOntologyBiologicalProcess	regulation of reciprocal meiotic recombination	PRDM9 PRDM7	1.07e-04	4	88	2	GO:0010520
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SUN2 SUN1	1.78e-04	5	88	2	GO:0021815
GeneOntologyBiologicalProcess	nuclear migration along microtubule	SUN2 SUN1	1.78e-04	5	88	2	GO:0030473
GeneOntologyBiologicalProcess	positive regulation of lipid kinase activity	INS INS-IGF2	1.78e-04	5	88	2	GO:0090218
GeneOntologyBiologicalProcess	vascular endothelial growth factor receptor signaling pathway	DAB2IP AXL NIBAN2 EPN2	2.16e-04	69	88	4	GO:0048010
GeneOntologyBiologicalProcess	negative regulation of respiratory burst involved in inflammatory response	INS INS-IGF2	2.67e-04	6	88	2	GO:0060266
GeneOntologyBiologicalProcess	regulation of NAD(P)H oxidase activity	INS INS-IGF2	2.67e-04	6	88	2	GO:0033860
GeneOntologyBiologicalProcess	neutrophil clearance	AXL XKR8	2.67e-04	6	88	2	GO:0097350
GeneOntologyBiologicalProcess	positive regulation of nuclear division	PRDM9 INS PRDM7 INS-IGF2	2.98e-04	75	88	4	GO:0051785
GeneOntologyBiologicalProcess	cell-substrate adhesion	NID2 AXL PKD1 PKHD1 LAMB1 UNC13D TESK1 TNXB	3.66e-04	410	88	8	GO:0031589
GeneOntologyBiologicalProcess	positive regulation of dendritic spine maintenance	INS INS-IGF2	3.73e-04	7	88	2	GO:1902952
GeneOntologyBiologicalProcess	cerebral cortex development	DAB2IP RELN SUN2 SUN1 LAMB1	4.18e-04	147	88	5	GO:0021987
GeneOntologyBiologicalProcess	centrosome localization	SUN2 SUN1 PKHD1	4.45e-04	35	88	3	GO:0051642
GeneOntologyBiologicalProcess	microtubule organizing center localization	SUN2 SUN1 PKHD1	4.84e-04	36	88	3	GO:0061842
GeneOntologyBiologicalProcess	negative regulation of respiratory burst	INS INS-IGF2	4.96e-04	8	88	2	GO:0060268
GeneOntologyBiologicalProcess	positive regulation of respiratory burst	INS INS-IGF2	7.92e-04	10	88	2	GO:0060267
GeneOntologyBiologicalProcess	positive regulation of synapse maturation	DAB2IP RELN	7.92e-04	10	88	2	GO:0090129
Domain	AMOP	ISM1 ISM2	1.31e-04	4	88	2	SM00723
Domain	AMOP	ISM1 ISM2	1.31e-04	4	88	2	PF03782
Domain	AMOP_dom	ISM1 ISM2	1.31e-04	4	88	2	IPR005533
Domain	AMOP	ISM1 ISM2	1.31e-04	4	88	2	PS50856
Domain	SUN	SUN2 SUN1	3.25e-04	6	88	2	PS51469
Domain	SUN_dom	SUN2 SUN1	4.54e-04	7	88	2	IPR012919
Domain	Sad1_UNC	SUN2 SUN1	4.54e-04	7	88	2	PF07738
Domain	SSXRD	PRDM9 PRDM7	6.03e-04	8	88	2	PF09514
Domain	SSXRD_motif	PRDM9 PRDM7	6.03e-04	8	88	2	IPR019041
Domain	Transglut_N	TGM5 EPB42	7.73e-04	9	88	2	PF00868
Domain	TRANSGLUTAMINASES	TGM5 EPB42	7.73e-04	9	88	2	PS00547
Domain	Transglutaminase_N	TGM5 EPB42	7.73e-04	9	88	2	IPR001102
Domain	Transglut_C	TGM5 EPB42	7.73e-04	9	88	2	PF00927
Domain	-	TGM5 EPB42	7.73e-04	9	88	2	3.90.260.10
Domain	Gln_gamma-glutamylTfrase_euk	TGM5 EPB42	7.73e-04	9	88	2	IPR023608
Domain	Transglutaminase_AS	TGM5 EPB42	7.73e-04	9	88	2	IPR013808
Domain	-	INS INS-IGF2	7.73e-04	9	88	2	1.10.100.10
Domain	EGF	TPO NID2 RELN BRINP2 LAMB1 TNXB	8.54e-04	235	88	6	SM00181
Domain	Insulin	INS INS-IGF2	9.64e-04	10	88	2	PF00049
Domain	Transglutaminase_C	TGM5 EPB42	9.64e-04	10	88	2	IPR008958
Domain	TGc	TGM5 EPB42	1.17e-03	11	88	2	SM00460
Domain	Transglut_core	TGM5 EPB42	1.17e-03	11	88	2	PF01841
Domain	KRAB_RELATED	PRDM9 PRDM7	1.17e-03	11	88	2	PS50806
Domain	Insulin	INS INS-IGF2	1.17e-03	11	88	2	IPR004825
Domain	Transglutaminase-like	TGM5 EPB42	1.17e-03	11	88	2	IPR002931
Domain	Insulin-like	INS INS-IGF2	1.17e-03	11	88	2	IPR016179
Domain	IlGF	INS INS-IGF2	1.17e-03	11	88	2	SM00078
Domain	Krueppel-associated_box-rel	PRDM9 PRDM7	1.66e-03	13	88	2	IPR003655
Domain	Ig_I-set	AXL SIGLEC6 CNTN3 CEACAM20 LRIT1	2.05e-03	190	88	5	IPR013098
Domain	ig	AXL SIGLEC6 CNTN3 CEACAM20 LRIT1	2.05e-03	190	88	5	PF00047
Domain	Immunoglobulin	AXL SIGLEC6 CNTN3 CEACAM20 LRIT1	2.05e-03	190	88	5	IPR013151
Domain	I-set	AXL SIGLEC6 CNTN3 CEACAM20 LRIT1	2.05e-03	190	88	5	PF07679
Domain	-	AXL SIGLEC6 PKHD1 CNTN3 CEACAM20 TNXB TGM5 EPB42 LRIT1	3.99e-03	663	88	9	2.60.40.10
Pubmed	Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells.	INS SYT7 INS-IGF2	6.69e-08	4	90	3	26216970
Pubmed	Expression and role of laminin-1 in mouse pancreatic organogenesis.	INS LAMB1 INS-IGF2	3.33e-07	6	90	3	10866045
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	NID2 CELA3B RELN INS LAMB1 TNXB INS-IGF2	3.81e-07	175	90	7	28071719
Pubmed	Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.	INS PKD1 PKHD1 INS-IGF2	2.32e-06	36	90	4	25715395
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	RELN SUN2 SUN1	5.97e-06	14	90	3	19874786
Pubmed	Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.	INS INS-IGF2	6.62e-06	2	90	2	9593767
Pubmed	SGLT1/2 inhibition improves glycemic control and multi-organ protection in type 1 diabetes.	INS INS-IGF2	6.62e-06	2	90	2	37520739
Pubmed	Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.	INS INS-IGF2	6.62e-06	2	90	2	19111542
Pubmed	Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis.	INS INS-IGF2	6.62e-06	2	90	2	35830687
Pubmed	Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes.	INS INS-IGF2	6.62e-06	2	90	2	26733677
Pubmed	Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.	INS INS-IGF2	6.62e-06	2	90	2	37628852
Pubmed	Proinsulin I and II gene expression in inbred mouse strains.	INS INS-IGF2	6.62e-06	2	90	2	2608062
Pubmed	Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling.	INS INS-IGF2	6.62e-06	2	90	2	27335233
Pubmed	Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice.	INS INS-IGF2	6.62e-06	2	90	2	14688305
Pubmed	Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.	INS INS-IGF2	6.62e-06	2	90	2	30480744
Pubmed	The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.	INS INS-IGF2	6.62e-06	2	90	2	34845324
Pubmed	SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.	INS INS-IGF2	6.62e-06	2	90	2	24226524
Pubmed	Genetic control of insulin receptors.	INS INS-IGF2	6.62e-06	2	90	2	7031649
Pubmed	UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.	SUN2 SUN1	6.62e-06	2	90	2	10375507
Pubmed	Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.	INS INS-IGF2	6.62e-06	2	90	2	16289958
Pubmed	Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertility.	INS INS-IGF2	6.62e-06	2	90	2	22522616
Pubmed	Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq.	INS INS-IGF2	6.62e-06	2	90	2	27855634
Pubmed	Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization.	INS INS-IGF2	6.62e-06	2	90	2	1346376
Pubmed	Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.	INS INS-IGF2	6.62e-06	2	90	2	26203118
Pubmed	Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice.	INS INS-IGF2	6.62e-06	2	90	2	23552863
Pubmed	Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways.	INS INS-IGF2	6.62e-06	2	90	2	27782077
Pubmed	Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice.	INS INS-IGF2	6.62e-06	2	90	2	16283623
Pubmed	Sun1 deficiency leads to cerebellar ataxia in mice.	SUN2 SUN1	6.62e-06	2	90	2	26035387
Pubmed	Type 1 diabetic Akita mice have low bone mass and impaired fracture healing.	INS INS-IGF2	6.62e-06	2	90	2	33662611
Pubmed	Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells.	INS INS-IGF2	6.62e-06	2	90	2	29995913
Pubmed	Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.	INS INS-IGF2	6.62e-06	2	90	2	15718275
Pubmed	Insulin-Deficient Mouse β-Cells Do Not Fully Mature but Can Be Remedied Through Insulin Replacement by Islet Transplantation.	INS INS-IGF2	6.62e-06	2	90	2	29029025
Pubmed	Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.	INS INS-IGF2	6.62e-06	2	90	2	20948967
Pubmed	Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.	INS INS-IGF2	6.62e-06	2	90	2	20520806
Pubmed	Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.	INS INS-IGF2	6.62e-06	2	90	2	16799061
Pubmed	Prevalence and Clinical Characteristics of PDX1 Variant Induced Diabetes in Chinese Early-Onset Type 2 Diabetes.	INS INS-IGF2	6.62e-06	2	90	2	37279936
Pubmed	An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.	INS INS-IGF2	6.62e-06	2	90	2	19778534
Pubmed	Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.	INS INS-IGF2	6.62e-06	2	90	2	26696124
Pubmed	In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye.	INS INS-IGF2	6.62e-06	2	90	2	35138346
Pubmed	Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets.	INS INS-IGF2	6.62e-06	2	90	2	25686499
Pubmed	Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.	INS INS-IGF2	6.62e-06	2	90	2	23209676
Pubmed	Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.	INS INS-IGF2	6.62e-06	2	90	2	27055260
Pubmed	Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells.	INS INS-IGF2	6.62e-06	2	90	2	12059784
Pubmed	Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.	INS INS-IGF2	6.62e-06	2	90	2	19801494
Pubmed	Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.	INS INS-IGF2	6.62e-06	2	90	2	33667544
Pubmed	Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.	INS INS-IGF2	6.62e-06	2	90	2	7729600
Pubmed	Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.	INS INS-IGF2	6.62e-06	2	90	2	25428948
Pubmed	Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.	SUN2 SUN1	6.62e-06	2	90	2	28747499
Pubmed	Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.	INS INS-IGF2	6.62e-06	2	90	2	26595448
Pubmed	Tyrosine nitration of prostacyclin synthase is associated with enhanced retinal cell apoptosis in diabetes.	INS INS-IGF2	6.62e-06	2	90	2	22015457
Pubmed	Altered Gut Microbiota Activate and Expand Insulin B15-23-Reactive CD8+ T Cells.	INS INS-IGF2	6.62e-06	2	90	2	30796028
Pubmed	Impact of genetic background on nephropathy in diabetic mice.	INS INS-IGF2	6.62e-06	2	90	2	16118394
Pubmed	High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.	INS INS-IGF2	6.62e-06	2	90	2	23391566
Pubmed	Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.	INS INS-IGF2	6.62e-06	2	90	2	28700945
Pubmed	Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.	INS INS-IGF2	6.62e-06	2	90	2	23275337
Pubmed	Novel diabetic mouse models as tools for investigating diabetic retinopathy.	INS INS-IGF2	6.62e-06	2	90	2	23251343
Pubmed	The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice.	INS INS-IGF2	6.62e-06	2	90	2	25789863
Pubmed	A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.	INS INS-IGF2	6.62e-06	2	90	2	17151334
Pubmed	Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice.	INS INS-IGF2	6.62e-06	2	90	2	21593201
Pubmed	Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.	INS INS-IGF2	6.62e-06	2	90	2	36170671
Pubmed	Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells.	INS INS-IGF2	6.62e-06	2	90	2	21723250
Pubmed	Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes.	INS INS-IGF2	6.62e-06	2	90	2	34675883
Pubmed	The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.	INS INS-IGF2	6.62e-06	2	90	2	15005713
Pubmed	Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?	INS INS-IGF2	6.62e-06	2	90	2	23228931
Pubmed	Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages.	INS INS-IGF2	6.62e-06	2	90	2	23894189
Pubmed	Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage.	INS INS-IGF2	6.62e-06	2	90	2	29439088
Pubmed	Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.	INS INS-IGF2	6.62e-06	2	90	2	22449801
Pubmed	Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.	INS INS-IGF2	6.62e-06	2	90	2	19874548
Pubmed	The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.	INS INS-IGF2	6.62e-06	2	90	2	29434227
Pubmed	Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy.	INS INS-IGF2	6.62e-06	2	90	2	35234250
Pubmed	Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.	INS INS-IGF2	6.62e-06	2	90	2	16936198
Pubmed	Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.	INS INS-IGF2	6.62e-06	2	90	2	19542201
Pubmed	SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness.	SUN2 SUN1	6.62e-06	2	90	2	37828059
Pubmed	Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.	INS INS-IGF2	6.62e-06	2	90	2	30019207
Pubmed	Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.	INS INS-IGF2	6.62e-06	2	90	2	27620487
Pubmed	Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney.	INS INS-IGF2	6.62e-06	2	90	2	31040360
Pubmed	Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.	INS INS-IGF2	6.62e-06	2	90	2	9465295
Pubmed	The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.	INS INS-IGF2	6.62e-06	2	90	2	15972000
Pubmed	Circulating sphingolipid biomarkers in models of type 1 diabetes.	INS INS-IGF2	6.62e-06	2	90	2	21068007
Pubmed	Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.	INS INS-IGF2	6.62e-06	2	90	2	28837672
Pubmed	Inducing Specific Immune Tolerance to Prevent Type 1 Diabetes in NOD Mice.	INS INS-IGF2	6.62e-06	2	90	2	26784909
Pubmed	Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.	INS INS-IGF2	6.62e-06	2	90	2	20153322
Pubmed	Noninvasive temporal detection of early retinal vascular changes during diabetes.	INS INS-IGF2	6.62e-06	2	90	2	33060607
Pubmed	Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.	SUN2 SUN1	6.62e-06	2	90	2	22863315
Pubmed	Transgenic Expression of miR-133a in the Diabetic Akita Heart Prevents Cardiac Remodeling and Cardiomyopathy.	INS INS-IGF2	6.62e-06	2	90	2	31069235
Pubmed	High fat diet induces brain insulin resistance and cognitive impairment in mice.	INS INS-IGF2	6.62e-06	2	90	2	27771511
Pubmed	Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.	INS INS-IGF2	6.62e-06	2	90	2	26552047
Pubmed	Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.	INS INS-IGF2	6.62e-06	2	90	2	22915034
Pubmed	Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes.	INS INS-IGF2	6.62e-06	2	90	2	34462258
Pubmed	Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.	INS INS-IGF2	6.62e-06	2	90	2	20825366
Pubmed	Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.	INS INS-IGF2	6.62e-06	2	90	2	19880509
Pubmed	Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions.	SUN2 SUN1	6.62e-06	2	90	2	25963820
Pubmed	Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.	INS INS-IGF2	6.62e-06	2	90	2	22065673
Pubmed	Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model.	INS INS-IGF2	6.62e-06	2	90	2	18788099
Pubmed	Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.	INS INS-IGF2	6.62e-06	2	90	2	17459508
Pubmed	Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.	INS INS-IGF2	6.62e-06	2	90	2	15889095
Pubmed	Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.	INS INS-IGF2	6.62e-06	2	90	2	7911222
Pubmed	GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney.	INS INS-IGF2	6.62e-06	2	90	2	28883608
Pubmed	Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.	INS INS-IGF2	6.62e-06	2	90	2	12540615
Pubmed	Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element.	INS INS-IGF2	6.62e-06	2	90	2	12914928
GeneFamily	Transglutaminases	TGM5 EPB42	2.35e-04	9	47	2	773
GeneFamily	Fibronectin type III domain containing	AXL CNTN3 TNXB LRIT1	7.83e-04	160	47	4	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SIGLEC6 CNTN3 CEACAM20 LRIT1	8.02e-04	161	47	4	593
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM9 PRDM7	8.77e-04	17	47	2	1197
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NID2 RELN SASH1 F2RL3 GDF3 F8	1.41e-06	173	90	6	7dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCell	droplet-Fat-Mat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 AQP8 CEACAM20 TGM5 SLC6A14	1.63e-05	156	90	5	cfd7f56f3155db677684827607e9008e975dbe70
ToppCell	droplet-Fat-Mat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 AQP8 CEACAM20 TGM5 SLC6A14	1.63e-05	156	90	5	0d79b4172896574b00faf00e87254f68d76f5512
ToppCell	droplet-Fat-Mat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 AQP8 CEACAM20 TGM5 SLC6A14	1.63e-05	156	90	5	f09150aacb6121f913648ed3918f9cd4f22c61f2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHBG KLK9 TNXB SLC6A14 LRIT1	1.68e-05	157	90	5	7fdc0094dd5729990a91a30c1982a14c74650b52
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-microglial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHBG KLK9 TNXB SLC6A14 LRIT1	1.68e-05	157	90	5	c762b03e254c73222094725ca8ac1c8eb428bccb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHBG KLK9 TNXB SLC6A14 LRIT1	1.68e-05	157	90	5	6b5b08bb5520fcf6f4c0560f7ed7645ec179806d
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	SHD NID2 AXL MRC2 LAMB1	2.33e-05	168	90	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN SASH1 F2RL3 GDF3 F8	2.99e-05	177	90	5	b1775e05c28883a15c56628028770bc59d3233fb
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACC1 URB1 BAZ2B SUN1 SLC6A14	3.15e-05	179	90	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 MACC1 RGL3 PKHD1 UNC13D	3.15e-05	179	90	5	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OVOL3 INS RGL3 SYT7 INS-IGF2	3.24e-05	180	90	5	0c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TPO NID2 LAMB1 TNXB F8	3.41e-05	182	90	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 RGL3 PKHD1 UNC13D NIBAN2	3.59e-05	184	90	5	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACC1 KLK9 NIBAN2 TGM5 SLC6A14	3.69e-05	185	90	5	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DLGAP1 SASH1 PKHD1 LAMB1	3.78e-05	186	90	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 DLGAP1 SASH1 PKHD1 LAMB1	3.88e-05	187	90	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 RGL3 PKHD1 UNC13D NIBAN2	3.88e-05	187	90	5	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Lymphatic\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	TPO RELN F2RL3 GDF3 TNXB	4.19e-05	190	90	5	8d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 AXL MRC2 LAMB1 TNXB	4.40e-05	192	90	5	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 AXL MRC2 LAMB1 TNXB	4.40e-05	192	90	5	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 AXL MRC2 LAMB1 TNXB	4.40e-05	192	90	5	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 AXL MRC2 LAMB1 TNXB	4.40e-05	192	90	5	ac1477433704573f95111eee6263b93668d2845e
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	NID2 SASH1 MRC2 LAMB1 TNXB	4.40e-05	192	90	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	facs-Lung-3m-Mesenchymal\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AXL MRC2 ISM1 LAMB1 TNXB	4.40e-05	192	90	5	8df15085b35b86f39debd933284cb703c5dd63c2
ToppCell	LAM-Endothelial-LymEndo\|LAM / Condition, Lineage and Cell class	NID2 RELN F2RL3 TNXB F8	4.51e-05	193	90	5	68eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	SASH1 AXL MRC2 LAMB1 TNXB	4.51e-05	193	90	5	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AXL MRC2 ISM1 LAMB1 TNXB	4.85e-05	196	90	5	d4676a6b0d9e417795fc9a6bcb1762d3dd656ca9
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 INS AXL ISM1 LAMB1	4.85e-05	196	90	5	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 INS AXL ISM1 LAMB1	4.85e-05	196	90	5	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ST6GALNAC1 NID2 F2RL3 ISM1 LAMB1	5.09e-05	198	90	5	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ST6GALNAC1 NID2 F2RL3 ISM1 LAMB1	5.09e-05	198	90	5	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	facs-Trachea-nan-3m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AXL MRC2 ISM1 LAMB1 TNXB	5.09e-05	198	90	5	0dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	RELN SASH1 F2RL3 TNXB F8	5.22e-05	199	90	5	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RELN SASH1 F2RL3 TNXB F8	5.22e-05	199	90	5	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RELN F2RL3 GDF3 TNXB F8	5.22e-05	199	90	5	1587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RELN F2RL3 GDF3 TNXB F8	5.22e-05	199	90	5	a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RELN SASH1 F2RL3 TNXB F8	5.22e-05	199	90	5	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	Control-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	AXL PKHD1 ADAMTSL4-AS1 CUEDC1	1.03e-04	120	90	4	840d0ac995e2fa41996514753e4e03c4aa4a26d0
ToppCell	\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SIGLEC6 SHBG BRINP2 CNTN3	1.06e-04	121	90	4	da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCell	Club-club-1\|World / Class top	ST6GALNAC1 TBC1D13 LAMB1	1.78e-04	54	90	3	48f80b20b1c4995a0f7084d31666781dce4009a9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	NID2 URB1 FAM120C LAMB1	2.49e-04	151	90	4	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	NID2 URB1 FAM120C LAMB1	2.49e-04	151	90	4	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELA3B INS AQP8 CEACAM20	2.49e-04	151	90	4	a306e8dac653bc785d805d8d2d94feec3cb01727
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	URB1 RPP21 MRC2 ISM2	2.62e-04	153	90	4	65641cc82883716dba0fefb749a30174a63f4da5
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F2RL3 FAM53A TDRD6 GDF3	3.10e-04	160	90	4	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	NID2 SYNJ2 TNXB MOCS1	3.18e-04	161	90	4	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	ST6GALNAC1 ISM1 CCDC187 LRRC7	3.25e-04	162	90	4	91cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN GDF3 TNXB F8	3.57e-04	166	90	4	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELA3B LAMB1 MOCS1 CUEDC1	3.57e-04	166	90	4	c22b0f3bf990d94b615a3aacee5de548da2db628
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	RELN GDF3 TNXB F8	3.57e-04	166	90	4	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	facs-Marrow-T_cells-18m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELA3B LAMB1 MOCS1 CUEDC1	3.57e-04	166	90	4	0975fc165bcc7e85f053d9d0244fffe407c23571
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	F2RL3 FAM53A CCDC187 TDRD6	3.57e-04	166	90	4	c11dcf9705b85ac3da6ae86358f5ffd64ae8327e
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN F2RL3 GDF3 TNXB	3.57e-04	166	90	4	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	NID2 SYNJ2 BRINP2 TNXB	3.65e-04	167	90	4	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	Sigmoid-Macrophage-Macrophage\|Macrophage / Region, Cell class and subclass	MACC1 SASH1 AXL SGPL1	3.73e-04	168	90	4	bb16e135b6ae0d66615420b61edd6f62f2a3233c
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INS SUN2 AQP8 CEACAM20	3.73e-04	168	90	4	03896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NID2 DLGAP1 ISM1 PKHD1	3.73e-04	168	90	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	INS RGL3 PKHD1 TDRD6	3.90e-04	170	90	4	985c2d5962100fab0d95bee39f382ccbe799331e
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	ENTPD7 SHD AXL SIGLEC6	3.90e-04	170	90	4	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	Endothelial-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	RELN F2RL3 GDF3 TNXB	3.99e-04	171	90	4	07ff7059071da83da1d8f266a586573920d75b58
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-CMP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TPO EEF2 OVOL3 AQP8	4.08e-04	172	90	4	f18d9f061df3da96e389616abd5edfc269d3adeb
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC2 ISM1 TNXB TGM5	4.08e-04	172	90	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Endothelial-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	RELN F2RL3 GDF3 TNXB	4.08e-04	172	90	4	d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell	wk_15-18-Hematologic-Myeloid-Mast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	F2RL3 SIGLEC6 UNC13D AQP8	4.08e-04	172	90	4	a7146c255031207e64682ef767884b11c96e0d59
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	RELN FAM120C AXL LAMB1	4.08e-04	172	90	4	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 AXL ISM1 LAMB1	4.17e-04	173	90	4	f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM120C INS AXL GDF3	4.17e-04	173	90	4	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 AXL ISM1 LAMB1	4.17e-04	173	90	4	cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TPO TDRD6 TGM5 CUEDC1	4.26e-04	174	90	4	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 INS AXL TNXB	4.26e-04	174	90	4	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	ENTPD7 URB1 ARID2 SUN1	4.45e-04	176	90	4	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Klk6_(Klk6)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SHBG CCDC187 TDRD6	4.53e-04	74	90	3	88d6112e16d537bbbb73f206f3388b5a951e68b4
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Klk6_(Klk6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SHBG CCDC187 TDRD6	4.53e-04	74	90	3	b61bfa778b295a05db58b231d1fca7cb69aab8c3
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	ENTPD7 URB1 ARID2 SUN1	4.54e-04	177	90	4	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID2 ISM1 LAMB1 MOCS1	4.64e-04	178	90	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN SASH1 TNXB F8	4.64e-04	178	90	4	ad3de3e03a401dac64431a541899445262246347
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SHBG KLK9 TDRD6	4.71e-04	75	90	3	574ed1836f6bf5fa38a53af0a05fa4437f68f36b
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SHBG KLK9 TDRD6	4.71e-04	75	90	3	45f7861bfeb1c6371b73cf2ea527801342e534bc
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	NID2 RELN AXL ISM1	4.74e-04	179	90	4	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MACC1 XIAP MLXIP MOCS1	4.74e-04	179	90	4	06d412fc096d88de168969466ce422f0ab5553b2
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RELN SASH1 TNXB F8	4.74e-04	179	90	4	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SYNJ2 MRC2 KCTD15 F8	4.74e-04	179	90	4	d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 AXL MRC2 TNXB	4.84e-04	180	90	4	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NID2 AXL ISM1 LAMB1	4.94e-04	181	90	4	dff264815a3569f5666d0bbc3867c0496cd78774
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	RELN F2RL3 GDF3 F8	4.94e-04	181	90	4	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	RELN F2RL3 GDF3 F8	4.94e-04	181	90	4	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 CNTN3 TNXB EPB42	4.94e-04	181	90	4	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MACC1 NIBAN2 SLC6A14 EPN2	4.94e-04	181	90	4	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MACC1 SASH1 PKHD1	4.94e-04	181	90	4	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN SASH1 F2RL3 F8	5.05e-04	182	90	4	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INS AXL MRC2 TNXB	5.05e-04	182	90	4	f4b74c2756989812abe4e7055ec8918f69d56025
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK9 CCDC187 TDRD6	5.09e-04	77	90	3	4d6e2486dd7702c4e0115567dd0a2c16617816aa
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	KLK9 CCDC187 TDRD6	5.09e-04	77	90	3	ddd54a5ef6a1fc8be1e852c2192204a749b819c1
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SASH1 F2RL3 GDF3 F8	5.15e-04	183	90	4	2d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ENTPD7 NID2 DLGAP1 URB1	5.15e-04	183	90	4	1464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 RGL3 PKHD1 UNC13D	5.15e-04	183	90	4	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	10x5'v1-week_17-19-Hematopoietic-erythroid\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ST6GALNAC1 STRADB RELN EPB42	5.26e-04	184	90	4	0efc757d9512d6a8fe8176e977a94e4494ed9778
ToppCell	(6)_Endothelial-F_(Lymphatics)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	RELN F2RL3 GDF3 F8	5.26e-04	184	90	4	03ea613e00b45c81b752c14505a0538d698f551e
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN GDF3 TNXB F8	5.26e-04	184	90	4	15cbddea9efb2346a2028d77edfe9ba32923568f
Disease	Malformation of cortical development	RELN LAMB1	1.14e-04	6	82	2	cv:C1955869
Disease	Lissencephaly	RELN LAMB1	1.14e-04	6	82	2	cv:C0266463
Disease	latent autoimmune diabetes in adults, type 2 diabetes mellitus	INS INS-IGF2	2.71e-04	9	82	2	EFO_0009706, MONDO_0005148
Disease	Malignant neoplasm of breast	NID2 EEF2 LMF2 SYNJ2 NUP133 PUS1 LRRC7 AQP8 TESK1 MAMDC4	7.79e-04	1074	82	10	C0006142
Disease	hearing loss	NID2 SYNJ2 SLC22A7	8.72e-04	67	82	3	EFO_0004238
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 PKHD1	8.93e-04	16	82	2	DOID:0110861 (implicated_via_orthology)
Disease	Metabolic Syndrome X	INS SHBG	1.55e-03	21	82	2	C0524620
Disease	Neoplasm Invasiveness	EEF2 INS AXL SHBG	1.75e-03	184	82	4	C0027626
Disease	age-related hearing impairment	NID2 LMF2 SASH1 SYNJ2 SLC6A14	2.12e-03	324	82	5	EFO_0005782
Disease	myeloperoxidase measurement	NUP133 TNXB	2.37e-03	26	82	2	EFO_0005243
Disease	HIV-1 infection	MACC1 SASH1 TNXB	2.60e-03	98	82	3	EFO_0000180

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGHFVLLDPTDPLAW	MAMDC4	691	Q6UXC1
RPALPQGYDGWQILH	EPB42	336	P16452
LNRAWNHAETLDPPG	CCDC187	746	A0A096LP49
FLQLWNPAPHTSNGR	ADAMTSL4-AS1	111	Q5T5F5
LAAHPQLASFPGAEW	BAZ2B	101	Q9UIF8
QWFLSGQPLLPSEHL	CEACAM20	286	Q6UY09
WESLFHPPRKLGIND	ARID2	266	Q68CP9
LHNPALFEGRSPAVW	DUS1L	236	Q6P1R4
AHPRPTSQDLAGFWD	DLGAP1	861	O14490
PARAFGPAVVANHWN	AQP8	211	O94778
LWGPDPAAAFVNQHL	INS	16	P01308
PNLHLLAEGAPIDWG	NIBAN2	576	Q96TA1
PNALDGNRDTPLHWA	ASB8	111	Q9H765
PWPHPGQSQLFADLS	AOC2	46	O75106
WGEHFEFHNLPPLRT	DAB2IP	256	Q5VWQ8
ELQLPPSDFHWSADL	NUP133	141	Q8WUM0
FWPRHNGNPHDLLDI	ENTPD7	101	Q9NQZ7
GVPWEYHDSNPNRSL	LRRC7	891	Q96NW7
PHLGLASRPNGDWSQ	EPN2	231	O95208
SVPWPQGAVHFNLLD	GDF3	171	Q9NR23
DWSRLHAVLPPNNGR	ISM2	536	Q6H9L7
HPDLPGLWLHQAFFS	TPO	511	P07202
RNWNPPLLGNLPDDF	CUEDC1	171	Q9NWM3
DWRFNEFPNPAAHAL	MED23	1091	Q9ULK4
WHPFEPNNFRDSLED	MRC2	466	Q9UBG0
YHDLPWRPAEGRNSN	LAMB1	316	P07942
LDPLAWDNHYGTQIP	F8	1581	P00451
WLQDHPQDFRDPPAH	RGL3	151	Q3MIN7
DLVHLLDGWAPNLAF	LRIT1	211	Q9P2V4
NPSIFSWDPLHVQGL	MOCS1	396	Q9NZB8
DDFNGNLHPDLWPEV	RELN	1806	P78509
NLHPDLWPEVYGAER	RELN	1811	P78509
DNGLAFPLKHPDSWR	PI4K2A	346	Q9BTU6
NWGHLPDQLRGDAYI	OVOL3	16	O00110
ALPLDAQASHWQPAF	F2RL3	231	Q96RI0
LFPHGESWGDQLLQE	NID2	36	Q14112
WNEASDLPLGLHFGP	PRDM9	261	Q9NQV7
AWPNPREIAHLGNAD	MLXIP	296	Q9HAP2
AFRNLSWPGLGLEDH	RGL4	91	Q8IZJ4
RPPDLAHDGRSLWLN	HDAC10	516	Q969S8
RLSGDWNPLHIDPNF	HSD17B4	506	P51659
WNPLHIDPNFASLAG	HSD17B4	511	P51659
PDEDLAAFHWSLLGP	FAM120C	321	Q9NX05
PINSGDLFVHPLWNR	CELA3B	101	P08861
QDPDLLHNWPDAFTL	MACC1	41	Q6ZN28
PNSQPWQAGLFHLTR	KLK9	31	Q9UKQ9
HWQILPGDPFDNSSR	EEF2	816	P13639
LDRWDLHAEPNPEAG	DGKZ	416	Q13574
LPGAPANFSHQDVWL	SLC22A7	51	Q9Y694
PSYHWDLAELLPNQS	SLC22A15	46	Q8IZD6
DSNFLNPPRGWDHTA	ISM1	186	B1AKI9
PSPHYRWQLNGSDID	CNTN3	56	Q9P232
LWGPDPAAAFVNQHL	INS-IGF2	16	F8WCM5
RNQWALVAPLPHSFL	KBTBD6	461	Q86V97
NASSWLPHLPAQLEG	PKD1	746	P98161
HALRGELYRPAWEPQ	PKD1	4111	P98161
LNPHWNETFLFEGFP	SYT7	196	O43581
EKQPWFHGPLNRADA	SHD	236	Q96IW2
PPQHWPADAVDFLSN	TDRD6	146	O60522
PLLGDYQDPFWNLLH	SYNJ2	1406	O15056
RQAGALPHEDLPFWL	LMF2	156	Q9BU23
FQRAPRGIPSWNDHG	SPATA31A6	891	Q5VVP1
RFGNDGLHEPLDWAQ	PUS1	346	Q9Y606
WNEASDLPLGLHFGP	PRDM7	261	Q9NQW5
NLRDIPQPHAEPWAF	SHBG	236	P04278
FLNDPGHLLWGDRPE	RPP21	101	Q9H633
PAHLSWFQGFPALNA	SIGLEC6	281	O43699
NQSEWDRLEHFAPPF	ST6GALNAC1	311	Q9NSC7
PNGIDHFFRDSWPLL	OR6T1	171	Q8NGN1
THSWFPERLPQDGDN	PKHD1	1931	P08F94
GWFLALEQQALPPHT	URB1	1021	O60287
DFAWSNPLHPDIFPG	SGPL1	166	O95470
GQHPLDWLLTDRGPF	BRINP2	51	Q9C0B6
HFAQDLWPQPGIKDS	ZNF738	111	Q8NE65
ADGPGFHSLEPWAQL	WDR90	306	Q96KV7
QNWPDYAHLTPRELA	XIAP	171	P98170
PPRSSLEELHGDANW	SUN2	81	Q9UH99
NAGWNQDPTHVIRFP	KCTD15	206	Q96SI1
LRLNWEAPPGAFDSF	TNXB	3671	P22105
GSQAFVHWQEPRAPL	AXL	346	P30530
LDPPSWLNDHIIGFA	SENP8	21	Q96LD8
QHRQSAALDPADWPD	SASH1	216	O94885
TFEDHPLNPNPDSRW	TBC1D13	96	Q9NVG8
GEPWNRAQHSLPRAA	TESK1	531	Q15569
QSLLHDGSPLSPFWQ	TGM5	546	O43548
PEPHPLQDNGSFLWF	ZBED9	181	Q6R2W3
PWLSPELLRQDLHGY	STRADB	231	Q9C0K7
LKQPLQGDSEAFPWH	SUN1	346	O94901
RPASNWGPYLEQHRG	SLC6A14	601	Q9UN76
ALDNFHRWFQPAIPS	UNC13D	581	Q70J99
LRWKLFHAELAPPQG	TEX13B	146	Q9BXU2
LWLRADPAGLHGSQP	XKR8	66	Q9H6D3
SGRLFPLELNDQSPW	FAM53A	36	Q6NSI3
SAPQGHFPRIPWANL	NLRP13	46	Q86W25