Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 RXRA ZNF354C RXRB ZNF436 ZFP57 ZNF507

6.78e-0914592613GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF76 IKZF1 ZNF142 ZNF317 ZNF337 ZNF548 RXRA ZNF354C RXRB ZNF436 ZFP57 ZNF507

5.67e-0814122612GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF76 IKZF1 IKZF2 ZNF317 ZNF548 RXRA ZNF354C RXRB ZNF507

1.63e-051244269GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF76 IKZF1 IKZF2 ZNF317 ZNF548 RXRA ZNF354C RXRB ZNF507

1.94e-051271269GO:0000987
GeneOntologyMolecularFunctionretinoic acid-responsive element binding

RXRA RXRB

3.41e-057262GO:0044323
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A6 FBN1 FBN2 FBN3

9.67e-05188264GO:0005201
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

1.07e-0412262GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

1.47e-0414262GO:0097493
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

RXRA RXRB

2.46e-0418262GO:0042809
GeneOntologyMolecularFunctioncalcium ion binding

DGKG CRTAC1 FBN1 FBN2 CAPS2 FBN3

3.30e-04749266GO:0005509
GeneOntologyMolecularFunctionnuclear steroid receptor activity

RXRA RXRB

4.80e-0425262GO:0003707
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

RXRA RXRB

8.91e-0434262GO:0046966
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

RXRA RXRB

2.32e-0355262GO:0042974
GeneOntologyMolecularFunctionnuclear receptor activity

RXRA RXRB

2.75e-0360262GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

RXRA RXRB

2.85e-0361262GO:0098531
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

8.45e-064252GO:0035583
GeneOntologyBiologicalProcessresponse to vitamin D

TRIM25 RXRA RXRB

1.29e-0538253GO:0033280
GeneOntologyBiologicalProcesspositive regulation of vitamin D receptor signaling pathway

RXRA RXRB

2.11e-056252GO:0070564
GeneOntologyBiologicalProcessregulation of response to nutrient levels

FBN1 RXRA RXRB

2.31e-0546253GO:0032107
GeneOntologyBiologicalProcesspositive regulation of bone mineralization

FBN2 RXRA RXRB

2.79e-0549253GO:0030501
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

3.93e-058252GO:0071694
GeneOntologyBiologicalProcesspositive regulation of biomineral tissue development

FBN2 RXRA RXRB

5.14e-0560253GO:0070169
GeneOntologyBiologicalProcessregulation of vitamin D receptor signaling pathway

RXRA RXRB

6.31e-0510252GO:0070562
GeneOntologyBiologicalProcesspositive regulation of ossification

FBN2 RXRA RXRB

6.84e-0566253GO:0045778
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

7.71e-0511252GO:0035581
GeneOntologyBiologicalProcessvitamin D receptor signaling pathway

RXRA RXRB

9.24e-0512252GO:0070561
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

1.09e-0413252GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

1.09e-0413252GO:1900116
GeneOntologyBiologicalProcessregulation of bone mineralization

FBN2 RXRA RXRB

1.78e-0491253GO:0030500
GeneOntologyBiologicalProcessresponse to vitamin

TRIM25 RXRA RXRB

2.35e-04100253GO:0033273
GeneOntologyBiologicalProcessventricular cardiac muscle cell differentiation

RXRA RXRB

2.38e-0419252GO:0055012
GeneOntologyBiologicalProcessregulation of biomineral tissue development

FBN2 RXRA RXRB

3.46e-04114253GO:0070167
GeneOntologyBiologicalProcesscellular response to vitamin D

RXRA RXRB

3.51e-0423252GO:0071305
GeneOntologyBiologicalProcesscellular response to vitamin

RXRA RXRB

6.42e-0431252GO:0071295
GeneOntologyBiologicalProcessregulation of ossification

FBN2 RXRA RXRB

7.27e-04147253GO:0030278
GeneOntologyBiologicalProcessbone mineralization

FBN2 RXRA RXRB

7.56e-04149253GO:0030282
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

RXRA RXRB

9.65e-0438252GO:0048384
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

ZNF76 IKZF1 ZNF142 IKZF2 RXRA RXRB ZNF507

1.02e-031390257GO:0045944
GeneOntologyBiologicalProcessmaternal placenta development

RXRA RXRB

1.29e-0344252GO:0001893
GeneOntologyBiologicalProcessresponse to nutrient

TRIM25 RXRA RXRB

1.57e-03192253GO:0007584
GeneOntologyBiologicalProcessplacenta development

FBN2 RXRA RXRB

1.69e-03197253GO:0001890
GeneOntologyBiologicalProcessmRNA transcription by RNA polymerase II

RXRA RXRB

1.80e-0352252GO:0042789
GeneOntologyBiologicalProcessbiomineral tissue development

FBN2 RXRA RXRB

1.84e-03203253GO:0031214
GeneOntologyBiologicalProcesscellular response to nutrient

RXRA RXRB

2.01e-0355252GO:0031670
GeneOntologyBiologicalProcessmRNA transcription

RXRA RXRB

2.16e-0357252GO:0009299
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 FBN3

4.84e-0713263GO:0001527
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

4.85e-06372HP:0012772
HumanPhenoCrumpled ear

FBN1 FBN2

2.42e-05672HP:0009901
Domain-

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

2.93e-1167926123.30.160.60
Domainzf-C2H2

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

3.71e-116932612PF00096
DomainZnf_C2H2/integrase_DNA-bd

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

3.78e-116942612IPR013087
DomainZINC_FINGER_C2H2_2

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

1.35e-107752612PS50157
DomainZINC_FINGER_C2H2_1

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

1.39e-107772612PS00028
DomainZnf_C2H2-like

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

1.84e-107962612IPR015880
DomainZnf_C2H2

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

2.10e-108052612IPR007087
DomainZnF_C2H2

PRDM13 ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

2.19e-108082612SM00355
DomainFBN

FBN1 FBN2 FBN3

2.39e-093263IPR011398
DomainTB

FBN1 FBN2 FBN3

8.35e-087263PF00683
Domain-

FBN1 FBN2 FBN3

1.33e-0782633.90.290.10
DomainTB_dom

FBN1 FBN2 FBN3

2.00e-079263IPR017878
DomainTB

FBN1 FBN2 FBN3

2.00e-079263PS51364
DomainEGF_CA

CRTAC1 FBN1 FBN2 FBN3

5.80e-0686264PF07645
DomaincEGF

FBN1 FBN2 FBN3

6.10e-0626263PF12662
DomaincEGF

FBN1 FBN2 FBN3

6.10e-0626263IPR026823
DomainKRAB

ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57

7.92e-06358266PS50805
DomainKRAB

ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57

7.92e-06358266PF01352
DomainEGF_Ca-bd_CS

CRTAC1 FBN1 FBN2 FBN3

9.36e-0697264IPR018097
DomainKRAB

ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57

9.41e-06369266SM00349
DomainKRAB

ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57

9.56e-06370266IPR001909
DomainEGF_CA

CRTAC1 FBN1 FBN2 FBN3

1.02e-0599264PS01187
DomainEGF_CA

CRTAC1 FBN1 FBN2 FBN3

2.32e-05122264SM00179
DomainEGF-like_Ca-bd_dom

CRTAC1 FBN1 FBN2 FBN3

2.47e-05124264IPR001881
DomainRetinoid-X_rcpt/HNF4

RXRA RXRB

8.33e-0510262IPR000003
DomainEGF_3

CRTAC1 FBN1 FBN2 FBN3

2.94e-04235264PS50026
DomainASX_HYDROXYL

FBN1 FBN2 FBN3

3.54e-04100263PS00010
DomainEGF-like_dom

CRTAC1 FBN1 FBN2 FBN3

3.66e-04249264IPR000742
DomainEGF_1

CRTAC1 FBN1 FBN2 FBN3

4.00e-04255264PS00022
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN1 FBN2 FBN3

4.20e-04106263IPR000152
DomainEGF-like_CS

CRTAC1 FBN1 FBN2 FBN3

4.37e-04261264IPR013032
DomainEGF_2

CRTAC1 FBN1 FBN2 FBN3

4.63e-04265264PS01186
DomainhEGF

FBN2 FBN3

6.89e-0428262PF12661
DomainGrowth_fac_rcpt_

FBN1 FBN2 FBN3

1.29e-03156263IPR009030
Domainzf-C4

RXRA RXRB

1.86e-0346262PF00105
DomainNUCLEAR_REC_DBD_1

RXRA RXRB

1.86e-0346262PS00031
DomainZnf_hrmn_rcpt

RXRA RXRB

1.86e-0346262IPR001628
DomainNuclear_hrmn_rcpt

RXRA RXRB

1.86e-0346262IPR001723
DomainZnF_C4

RXRA RXRB

1.86e-0346262SM00399
DomainNUCLEAR_REC_DBD_2

RXRA RXRB

1.86e-0346262PS51030
Domain-

RXRA RXRB

1.94e-03472621.10.565.10
DomainNucl_hrmn_rcpt_lig-bd

RXRA RXRB

2.02e-0348262IPR000536
DomainHormone_recep

RXRA RXRB

2.02e-0348262PF00104
DomainHOLI

RXRA RXRB

2.02e-0348262SM00430
Domain-

RXRA RXRB

2.84e-03572623.30.50.10
DomainZnf_NHR/GATA

RXRA RXRB

2.94e-0358262IPR013088
DomainEGF

FBN1 FBN2 FBN3

4.13e-03235263SM00181
Domainzf-C2H2_6

ZNF317 ZNF548 ZNF354C

9.19e-03314263PF13912
DomainEF-hand_1

DGKG CAPS2

1.88e-02152262PF00036
DomainEFh

DGKG CAPS2

2.02e-02158262SM00054
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 FBN3

3.30e-0625173M39713
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2 FBN3

1.10e-0537173M27134
PathwayKEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION

RXRA RXRB

1.37e-055172M49023
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_GLUCONEOGENESIS

RXRA RXRB

1.37e-055172M29812
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_LIMIT_CHOLESTEROL_UPTAKE

RXRA RXRB

1.37e-055172M29791
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_TRIGLYCERIDE_LIPOLYSIS_IN_ADIPOSE

RXRA RXRB

1.37e-055172M29792
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2 FBN3

1.87e-0544173M26969
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A6 FBN1 FBN2 FBN3

2.01e-05140174M587
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

RXRA RXRB

2.05e-056172MM15663
PathwayWP_VITAMIN_A1_AND_A5X_PATHWAYS

RXRA RXRB

2.05e-056172M48097
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

RXRA RXRB

4.90e-059172M29809
PathwayKEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY

RXRA RXRB

4.90e-059172M47629
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_LINKED_TO_LIPOGENESIS

RXRA RXRB

4.90e-059172M29789
PathwayWP_VITAMIN_D_METABOLISM

RXRA RXRB

6.12e-0510172M39352
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

CPSF4 ZNF317 ZNF337 ZNF548 RXRA ZNF354C RXRB ZNF436

9.28e-051387178M734
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

RXRA RXRB

1.06e-0413172MM15622
PathwayKEGG_SMALL_CELL_LUNG_CANCER

COL4A6 RXRA RXRB

1.31e-0484173M3228
PathwayWP_SMALL_CELL_LUNG_CANCER

COL4A6 RXRA RXRB

1.94e-0496173M39834
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

COL4A6 FBN1 FBN2

3.22e-04114173MM14571
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A6 FBN1 FBN2 FBN3

3.84e-04300174M610
PathwayPID_RXR_VDR_PATHWAY

RXRA RXRB

4.37e-0426172M162
PathwayKEGG_THYROID_CANCER

RXRA RXRB

5.45e-0429172M523
PathwayPID_RETINOIC_ACID_PATHWAY

RXRA RXRB

5.84e-0430172M207
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 FBN2

6.65e-0432172MM14854
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

RXRA RXRB

8.89e-0437172M29790
PathwayWP_NUCLEAR_RECEPTORS

RXRA RXRB

9.38e-0438172MM15865
PathwayWP_NUCLEAR_RECEPTORS

RXRA RXRB

9.38e-0438172M39657
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 FBN2

9.88e-0439172MM14601
PathwayWP_VITAMIN_A_AND_CAROTENOID_METABOLISM

RXRA RXRB

1.20e-0343172M39554
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

RXRA RXRB

1.20e-0343172M27443
PathwayPID_INTEGRIN3_PATHWAY

COL4A6 FBN1

1.20e-0343172M53
PathwayWP_RETINOL_METABOLISM

RXRA RXRB

1.26e-0344172MM15851
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

RXRA RXRB

1.37e-0346172M239
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

RXRA RXRB

1.43e-0347172M29777
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

RXRA RXRB

1.49e-0348172MM14987
PathwayREACTOME_SIGNALING_BY_RETINOIC_ACID

RXRA RXRB

1.56e-0349172MM15186
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

RXRA RXRB

1.82e-0353172M8276
PathwayPID_AR_TF_PATHWAY

RXRA RXRB

1.82e-0353172M151
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

RXRA RXRB

1.89e-0354172M19818
PathwayPID_INTEGRIN1_PATHWAY

COL4A6 FBN1

2.81e-0366172M18
PathwayWP_PPAR_SIGNALING

RXRA RXRB

2.89e-0367172M39553
PathwayKEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY

RXRA RXRB

2.89e-0367172M10462
PathwayKEGG_PPAR_SIGNALING_PATHWAY

RXRA RXRB

3.06e-0369172M13088
PathwayWP_NONSMALL_CELL_LUNG_CANCER

RXRA RXRB

3.33e-0372172M39738
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

COL4A6 FBN1 FBN2

3.41e-03258173MM14572
PathwayWP_PPAR_SIGNALING_PATHWAY

RXRA RXRB

3.42e-0373172MM15995
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

RXRA RXRB

3.61e-0375172M39568
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A6 FBN1

3.70e-0376172MM14867
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

COL4A6 FBN1

4.61e-0385172M16441
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

CPSF4 ZNF317 RXRA ZNF354C RXRB

5.88e-031022175MM15436
PathwayKEGG_PATHWAYS_IN_CANCER

COL4A6 RXRA RXRB

6.49e-03325173M12868
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

RXRA RXRB

8.70e-03118172M27316
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2 FBN3

1.48e-09426325034023
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF76 CPSF4 IKZF2 RXRA ZNF354C RXRB ZFP57 ZNF507

8.84e-0880826820412781
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

5.37e-07226212399449
Pubmed

Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.

RXRA RXRB

5.37e-07226233246082
Pubmed

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

RXRA RXRB

5.37e-0722627926783
Pubmed

Endogenous retinoid X receptor ligands in mouse hematopoietic cells.

RXRA RXRB

5.37e-07226229089448
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

5.37e-07226221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

5.37e-07226212429739
Pubmed

Helios deficiency has minimal impact on T cell development and function.

IKZF1 IKZF2

5.37e-07226219620299
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

5.37e-07226224833718
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

5.37e-07226230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

5.37e-07226221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

5.37e-07226215131124
Pubmed

Three retinoid X receptor gene polymorphisms in plaque psoriasis and psoriasis guttata.

RXRA RXRB

5.37e-07226217341859
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

5.37e-07226224265020
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

5.37e-07226212524050
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

5.37e-07226220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

5.37e-07226225524144
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

5.37e-07226220404337
Pubmed

Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin.

RXRA RXRB

5.37e-07226216199515
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

5.37e-07226223133647
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

5.37e-0722628791520
Pubmed

Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.

RXRA RXRB

5.37e-07226224810760
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

5.37e-0722628120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

5.37e-07226235419902
Pubmed

Limited degradation of retinoid X receptor by calpain.

RXRA RXRB

5.37e-0722628780715
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

5.37e-0722628307578
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

5.37e-07226216407178
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

5.37e-07226210504303
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

5.37e-0722621852206
Pubmed

Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.

RXRA RXRB

5.37e-07226220798333
Pubmed

A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development.

RXRA RXRB

5.37e-07226219255444
Pubmed

Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.

RXRA RXRB

5.37e-07226222316320
Pubmed

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.

IKZF1 IKZF2

5.37e-07226217681952
Pubmed

[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].

IKZF1 IKZF2

5.37e-07226222931634
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

5.37e-07226210359653
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

5.37e-07226215221638
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

5.37e-0722627744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

5.37e-07226226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

5.37e-07226218006876
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

IKZF1 CPSF4 IKZF2 RXRA RXRB ZNF436 ZFP57

6.67e-0770926722988430
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF1 IKZF2

1.61e-06326220432734
Pubmed

Retinoid X receptors: X-ploring their (patho)physiological functions.

RXRA RXRB

1.61e-06326215608692
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

1.61e-06326210825173
Pubmed

Chromosomal localization of the human retinoid X receptors.

RXRA RXRB

1.61e-0632628034312
Pubmed

Unique response pathways are established by allosteric interactions among nuclear hormone receptors.

RXRA RXRB

1.61e-0632627758108
Pubmed

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

RXRA RXRB

1.61e-0632629727070
Pubmed

Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.

RXRA RXRB

1.61e-0632627831303
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF1 IKZF2

1.61e-06326227502439
Pubmed

Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains.

RXRA RXRB

1.61e-0632628631847
Pubmed

Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma.

RXRA RXRB

1.61e-06326219188585
Pubmed

Retinoid receptors trigger neuritogenesis in retinal degenerations.

RXRA RXRB

1.61e-06326221940995
Pubmed

An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.

RXRA RXRB

1.61e-0632627990953
Pubmed

The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.

RXRA RXRB

1.61e-06326211839661
Pubmed

Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1.

RXRA RXRB

1.61e-06326227184385
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

1.61e-06326230201140
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF1 IKZF2

1.61e-06326211937265
Pubmed

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

RXRA RXRB

1.61e-0632621312497
Pubmed

Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription.

RXRA RXRB

1.61e-06326219897601
Pubmed

Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.

RXRA RXRB

1.61e-06326218375961
Pubmed

Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.

RXRA RXRB

1.61e-0632627980510
Pubmed

Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

RXRA RXRB

1.61e-06326218217139
Pubmed

Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.

RXRA RXRB

1.61e-06326210049761
Pubmed

Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.

RXRA RXRB

1.61e-06326212514092
Pubmed

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.

RXRA RXRB

1.61e-06326211053444
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF1 IKZF2

1.61e-0632629560339
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

1.61e-06326220855508
Pubmed

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

RXRA RXRB

1.61e-0632628799145
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF1 IKZF2

1.61e-06326218332232
Pubmed

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression.

RXRA RXRB

3.22e-06426210594021
Pubmed

Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.

RXRA RXRB

3.22e-0642628670810
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

3.22e-06426212429738
Pubmed

Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.

RXRA RXRB

3.22e-0642629804293
Pubmed

Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.

RXRA RXRB

3.22e-0642621310259
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

3.22e-06426225406291
Pubmed

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

RXRA RXRB

3.22e-0642627481822
Pubmed

Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.

RXRA RXRB

3.22e-06426210079186
Pubmed

Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.

RXRA RXRB

3.22e-0642628524212
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

3.22e-06426220729550
Pubmed

RXRs control serous macrophage neonatal expansion and identity and contribute to ovarian cancer progression.

RXRA RXRB

3.22e-06426232246014
Pubmed

The retinoid receptors.

RXRA RXRB

3.22e-0642627967725
Pubmed

Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.

RXRA RXRB

3.22e-06426226355550
Pubmed

Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.

RXRA RXRB

3.22e-06426210611353
Pubmed

Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity.

RXRA RXRB

3.22e-06426212549917
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

3.22e-06426216835936
Pubmed

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

RXRA RXRB

3.22e-06426219686701
Pubmed

Retinoid X receptors are essential for early mouse development and placentogenesis.

RXRA RXRB

3.22e-0642629892670
Pubmed

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

RXRA RXRB

3.22e-0642629348290
Pubmed

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

RXRA RXRB

3.22e-06426225574839
Pubmed

Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.

RXRA RXRB

3.22e-06426223896434
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

5.37e-06526226601954
Pubmed

Retinoic acid signaling is necessary for the development of the organ of Corti.

RXRA RXRB

5.37e-06526210452855
Pubmed

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

RXRA RXRB

5.37e-0652627705655
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF1 IKZF2

5.37e-06526210978333
Pubmed

Developmental expression of murine retinoid X receptor (RXR) genes.

RXRA RXRB

5.37e-0652628199055
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

5.37e-06526217255108
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2

5.37e-06526234411563
Pubmed

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.

RXRA RXRB

5.37e-0652629053308
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

5.37e-06526212590922
Pubmed

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.

RXRA RXRB

5.37e-06526216880407
InteractionLMO1 interactions

ZNF76 IKZF1 ZNF354C ZNF507

3.09e-05154244int:LMO1
InteractionMFAP5 interactions

FBN1 FBN2 ZNF507

3.16e-0552243int:MFAP5
InteractionZFP41 interactions

FBN1 FBN2 TRIM25

4.16e-0557243int:ZFP41
InteractionFBLN2 interactions

COL4A6 ZNF142 FBN1

6.46e-0566243int:FBLN2
InteractionTDG interactions

IKZF1 TRIM25 RXRA

7.38e-0569243int:TDG
InteractionMFAP2 interactions

FBN1 FBN2

8.91e-0512242int:MFAP2
InteractionSMYD4 interactions

GMCL2 TRIM25

1.41e-0415242int:SMYD4
InteractionKLHDC3 interactions

CRTAC1 IKZF1 TRIM25

1.47e-0487243int:KLHDC3
InteractionNCOR2 interactions

DGKG IKZF1 TRIM25 RXRA

2.49e-04264244int:NCOR2
InteractionNR2E3 interactions

RXRA RXRB

2.82e-0421242int:NR2E3
InteractionPPARD interactions

TRIM25 RXRA RXRB

3.53e-04117243int:PPARD
InteractionNTN5 interactions

FBN1 FBN2

3.69e-0424242int:NTN5
InteractionDGKD interactions

DGKG TRIM25

4.01e-0425242int:DGKD
InteractionIKZF2 interactions

IKZF1 IKZF2

4.34e-0426242int:IKZF2
InteractionDNASE2 interactions

FBN1 TRIM25

4.34e-0426242int:DNASE2
InteractionNR4A2 interactions

RXRA RXRB

4.68e-0427242int:NR4A2
InteractionIKZF3 interactions

ZNF76 IKZF1 IKZF2 TRIM25

5.16e-04320244int:IKZF3
InteractionELN interactions

FBN1 FBN2

5.41e-0429242int:ELN
InteractionZNF460 interactions

ZNF142 TRIM25 ZNF337

5.72e-04138243int:ZNF460
InteractionZNF580 interactions

IKZF1 ZNF436

6.60e-0432242int:ZNF580
InteractionNR1H4 interactions

RXRA RXRB

6.60e-0432242int:NR1H4
InteractionZNF408 interactions

FBN1 FBN2 ZNF317

6.61e-04145243int:ZNF408
InteractionNOTCH1 interactions

COL4A6 IKZF1 IKZF2 TRIM25

6.84e-04345244int:NOTCH1
InteractionIKZF4 interactions

IKZF1 IKZF2

8.35e-0436242int:IKZF4
InteractionGMCL2 interactions

GMCL2 IKZF1

8.35e-0436242int:GMCL2
InteractionSP1 interactions

FBN1 FBN2 TRIM25 RXRA

8.44e-04365244int:SP1
InteractionLHX4 interactions

ZNF76 IKZF1 ZNF354C

9.78e-04166243int:LHX4
InteractionUBE3D interactions

CPSF4 TRIM25

9.80e-0439242int:UBE3D
InteractionIGHG1 interactions

IKZF1 TRIM25 ZNF354C

1.03e-03169243int:IGHG1
InteractionGATA1 interactions

IKZF1 CPSF4 TRIM25

1.07e-03171243int:GATA1
InteractionTGIF1 interactions

RXRA RXRB

1.08e-0341242int:TGIF1
InteractionPSMC3IP interactions

TRIM25 RXRA

1.08e-0341242int:PSMC3IP
InteractionDCN interactions

COL4A6 FBN1

1.19e-0343242int:DCN
InteractionTHRB interactions

FBN2 RXRA RXRB

1.36e-03186243int:THRB
InteractionRARB interactions

RXRA RXRB

1.36e-0346242int:RARB
InteractionAEN interactions

IKZF1 ZNF317

1.42e-0347242int:AEN
InteractionNR1I2 interactions

RXRA RXRB

1.48e-0348242int:NR1I2
InteractionTBL1XR1 interactions

DGKG IKZF1 TRIM25

1.49e-03192243int:TBL1XR1
InteractionCLK2 interactions

CPSF4 ZNF317 ZNF436

1.55e-03195243int:CLK2
InteractionKRT40 interactions

ZNF76 ZNF317 ZNF337 RXRB

1.60e-03434244int:KRT40
InteractionZNHIT3 interactions

TRIM25 RXRA

1.61e-0350242int:ZNHIT3
InteractionFBN1 interactions

FBN1 FBN2

1.67e-0351242int:FBN1
InteractionTAF11 interactions

RXRA RXRB

1.67e-0351242int:TAF11
InteractionKLHDC10 interactions

IKZF1 TRIM25

1.94e-0355242int:KLHDC10
InteractionRASL10B interactions

TRIM25 ZNF507

2.01e-0356242int:RASL10B
InteractionLHX6 interactions

ZNF76 ZNF507

2.16e-0358242int:LHX6
InteractionRARG interactions

RXRA RXRB

2.16e-0358242int:RARG
InteractionNR1H3 interactions

RXRA RXRB

2.16e-0358242int:NR1H3
InteractionRARA interactions

TRIM25 RXRA RXRB

2.28e-03223243int:RARA
InteractionCASP2 interactions

TRIM25 RXRA

2.31e-0360242int:CASP2
Cytoband19p13

ZNF317 FBN3

1.07e-042726219p13
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF76 IKZF1 ZNF142 IKZF2 ZNF317 ZNF337 ZNF548 ZNF354C ZNF436 ZFP57 ZNF507

2.03e-11718191128
GeneFamilyNuclear hormone receptors

RXRA RXRB

1.19e-034919271
GeneFamilyEF-hand domain containing

DGKG CAPS2

2.18e-02219192863
CoexpressionURS_ADIPOCYTE_DIFFERENTIATION_UP

DGKG RXRA RXRB

3.37e-0566253M15476
CoexpressionGSE21063_WT_VS_NFATC1_KO_8H_ANTI_IGM_STIM_BCELL_DN

ZNF142 IKZF2 RXRB ZNF436

3.67e-05200254M8278
CoexpressionBENPORATH_ES_WITH_H3K27ME3

COL4A6 PRDM13 DGKG CRTAC1 FBN1 FBN2 ZNF436

6.06e-051115257M10371
CoexpressionHARALAMBIEVA_PBMC_DRYVAX_AGE_18_40YO_STIMULATED_VS_UNSTIMULATED_9_TO_34MO_UP

IKZF1 IKZF2

1.18e-0417252M41189
CoexpressionNABA_CORE_MATRISOME

COL4A6 FBN1 FBN2 FBN3

1.26e-04275254M5884
CoexpressionACEVEDO_METHYLATED_IN_LIVER_CANCER_DN

DGKG GMCL2 CRTAC1 IKZF1 IKZF2 SLC45A4

1.38e-04873256M16009
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|343B / Donor, Lineage, Cell class and subclass (all cells)

IKZF2 ZNF337 RXRB ZFP57

3.31e-06178264ec6364432d37a32f5152d36d89f5e96dddb72a9d
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IKZF2 ZNF337 RXRB ZFP57

3.61e-06182264c98da2db197b1531204e116600ff51891e5c17af
DrugBexarotene

RXRA RXRB

3.47e-063252DB00307
Drug2-hydroxyphytanic acid

RXRA RXRB

3.47e-063252ctd:C002585
DrugAC1O5SBP

RXRA RXRB

3.47e-063252CID006439746
Drugrosavin

FBN1 FBN2 RXRA

5.68e-0632253ctd:C529148
DrugRetinoids

FBN1 RXRA RXRB

6.84e-0634253ctd:D012176
DrugAGN 190727

RXRA RXRB

6.94e-064252CID006439768
Drug7-methoxycitronellal

RXRA RXRB

1.16e-055252CID000019223
Drug13,14-dihydroretinol

RXRA RXRB

1.16e-055252CID000446798
Drug7-methoxycitronellic acid

RXRA RXRB

1.16e-055252CID000171516
DrugAlitretinoin

RXRA RXRB

1.73e-056252DB00523
DrugMethoprene

RXRA RXRB

1.73e-056252ctd:D008726
DrugAdapalene

RXRA RXRB

1.73e-056252DB00210
DrugEtretinate

RXRA RXRB

1.73e-056252DB00926
Drugtriphenyltin hydroxide

RXRA RXRB

1.73e-056252ctd:C007567
DrugAcitretin

RXRA RXRB

2.42e-057252DB00459
DrugAGN 191659

RXRA RXRB

2.42e-057252CID006366726
DrugAGN 190121

RXRA RXRB

2.42e-057252CID006441236
Drugdesmosine

FBN1 FBN2 FBN3

2.64e-0553253CID000025435
DrugHX 600

RXRA RXRB

3.23e-058252ctd:C104181
DrugTTNN

RXRA RXRB

3.23e-058252CID000135754
DrugAC1O5JP6

RXRA RXRB

3.23e-058252CID006435379
DrugPropolis

FBN1 FBN2 RXRA

3.84e-0560253ctd:D011429
DrugForskolin, from Coleus forskohlii; Up 200; 0.5uM; PC3; HT_HG-U133A

COL4A6 FBN1 ZNF337 RXRA

4.48e-051832547059_UP
DrugHX 630

RXRA RXRB

5.18e-0510252ctd:C422175
Drugdiazepinylbenzoic acid

RXRA RXRB

5.18e-0510252ctd:C438269
Drug3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

ZNF76 IKZF1 FBN1 TRIM25

5.85e-051962543742_DN
Drugnovobiocin sodium, USP; Down 200; 100uM; PC3; HG-U133A

ZNF142 FBN1 TRIM25 RXRA

5.96e-05197254435_DN
Drugaspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A

CRTAC1 IKZF1 TRIM25 ZNF337

5.96e-051972542664_UP
DrugFlurandrenolide [1524-88-5]; Down 200; 9.2uM; HL60; HT_HG-U133A

ZNF76 FBN1 TRIM25 ZNF337

6.08e-051982542184_DN
DrugAGN 191701

RXRA RXRB

6.33e-0511252CID006438168
Drug1xqc

FBN2 FBN3

6.33e-0511252CID005287617
DrugUVI 3003

RXRA RXRB

6.33e-0511252ctd:C525131
DrugMusk T

RXRA RXRB

6.33e-0511252CID000061014
Drugdi-n-propylphthalate

RXRA RXRB

7.59e-0512252ctd:C106479
DrugNSC46155

RXRA RXRB

7.59e-0512252CID000457869
Drugtazarotenic acid

RXRA RXRB

8.96e-0513252CID000147525
DrugGW2331

RXRA RXRB

8.96e-0513252CID000657048
DrugCd2665

RXRA RXRB

8.96e-0513252CID000216241
DrugSulfonamides

RXRA RXRB

1.04e-0414252ctd:D013449
DrugAC1L1DMQ

RXRA RXRB

1.04e-0414252CID000002418
Drugphthalic acid

RXRA RXRB

1.56e-0417252ctd:C032279
Drugphytanic acid

CPSF4 RXRA RXRB

1.56e-0496253CID000026840
DrugHX600

RXRA RXRB

1.75e-0418252CID000128016
Drugandrost-2-en-3-ol

RXRA RXRB

1.75e-0418252CID000166036
DrugChlorogenic Acid

FBN1 FBN2 RXRA

1.92e-04103253ctd:D002726
DrugTAAD

FBN1 FBN2

2.40e-0421252CID000133445
Drugdiheptyl phthalate

RXRA RXRB

2.40e-0421252ctd:C089799
Drugdi-n-hexyl phthalate

RXRA RXRB

2.64e-0422252ctd:C027387
Drugadapalene

RXRA RXRB

2.64e-0422252CID000060164
DrugAC1Q6CTU

FBN1 RXRA RXRB

2.87e-04118253CID000021362
DrugRo 15-0778

RXRA RXRB

2.89e-0423252CID006436116
Drugscoparone

RXRA RXRB

3.42e-0425252CID000008417
DrugPrt-H

RXRA RXRB

3.70e-0426252CID003050291
DrugAC1L2X6Z

RXRA RXRB

4.00e-0427252CID000130325
Drugtamibarotene

IKZF1 FBN2 TRIM25 RXRA RXRB

4.16e-04596255ctd:C061133
DrugSR-12813

RXRA RXRB

4.61e-0429252CID000446313
DrugAGN 193109

RXRA RXRB

5.28e-0431252CID000177238
DrugT0070907

RXRA RXRB

5.28e-0431252CID002777391
Drugisodesmosine

FBN1 FBN2

5.99e-0433252CID000013811
DrugCD367

RXRA RXRB

5.99e-0433252CID000119342
DrugNSC49080

FBN1 FBN2

5.99e-0433252CID000002192
DrugAC1L3LFV

RXRA RXRB

5.99e-0433252CID000091134
DrugDR-0

RXRA RXRB

6.74e-0435252CID010062716
Drug2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene

RXRA RXRB

7.13e-0436252ctd:C054919
DrugRo 41-5253

RXRA RXRB

7.53e-0437252CID005312120
DrugCycloheximide [66-81-9]; Down 200; 14.2uM; HL60; HT_HG-U133A

PRDM13 IKZF1 ZNF337

8.48e-041712532723_DN
Drugtazarotene

RXRA RXRB

8.80e-0440252CID000005381
Drug17-DMAG; Up 200; 0.1uM; HL60; HT_HG-U133A

DGKG TRIM25 ZNF337

8.92e-041742532673_UP
Drugacyclic retinoid

RXRA RXRB

9.25e-0441252CID006437836
Drugvitamin D3 analog

RXRA RXRB

9.25e-0441252CID006438384
Drugecdysone

FBN1 RXRA RXRB

9.52e-04178253CID000019212
Drug2-propylpentanoic acid; Down 200; 1000uM; HL60; HT_HG-U133A

ZNF76 IKZF1 RXRA

1.10e-031872532669_DN
DrugAC1L1HRY

RXRA RXRB

1.11e-0345252CID000004265
DrugEtretinate-d3

RXRA RXRB

1.11e-0345252CID000003312
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

IKZF1 TRIM25 RXRA

1.15e-031902532137_DN
DrugS-(+)-Methoprene

RXRA RXRB

1.16e-0346252CID000038532
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

PRDM13 ZNF76 IKZF1

1.17e-031912532685_DN
DrugN6-methyladenosine [1867-73-8]; Down 200; 14.2uM; HL60; HT_HG-U133A

PRDM13 FBN2 ZNF337

1.18e-031922531271_DN
DrugOleandomycin phosphate [7060-74-4]; Up 200; 5uM; PC3; HG-U133A

IKZF1 ZNF142 ZNF337

1.22e-031942531935_UP
DrugFlumethasone [2135-17-3]; Up 200; 9.8uM; MCF7; HT_HG-U133A

DGKG IKZF1 FBN2

1.22e-031942533610_UP
DrugSulfamonomethoxine [1220-83-3]; Down 200; 14.2uM; HL60; HT_HG-U133A

DGKG TRIM25 ZNF337

1.22e-031942532742_DN
DrugDydrogesterone [152-62-5]; Down 200; 12.8uM; HL60; HT_HG-U133A

DGKG IKZF1 TRIM25

1.24e-031952532156_DN
DrugPivmecillinam hydrochloride [32887-03-9]; Down 200; 8.4uM; HL60; HT_HG-U133A

ZNF76 TRIM25 ZNF337

1.24e-031952532973_DN
Drugestradiol, USP; Up 200; 0.1uM; HL60; HT_HG-U133A

DGKG TRIM25 ZNF337

1.24e-031952532668_UP
DrugRepaglinide [135062-02-1]; Up 200; 8.8uM; HL60; HT_HG-U133A

DGKG FBN1 TRIM25

1.24e-031952536135_UP
DrugAcemetacin [53164-05-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

IKZF1 FBN2 ZNF337

1.24e-031952532411_UP
DrugPhentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A

DGKG ZNF76 CRTAC1

1.26e-031962533971_UP
DrugMetampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; HL60; HG-U133A

CRTAC1 IKZF1 RXRA

1.26e-031962531440_UP
DrugNiacin [59-67-6]; Up 200; 32.4uM; MCF7; HT_HG-U133A

ZNF76 TRIM25 ZNF337

1.26e-031962535301_UP
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2 FBN3

4.73e-103243DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

3.80e-064242DOID:0060249 (is_implicated_in)
DiseaseAbnormality of refraction

FBN1 FBN2 RXRA FBN3 SLC45A4

1.80e-04673245HP_0000539
Diseasenasopharyngeal neoplasm

CRTAC1 ZFP57 ZNF507

2.46e-04151243EFO_0004252
Diseasecortical surface area measurement

CRTAC1 FBN1 FBN2 ZNF354C FBN3 SLC45A4

5.88e-041345246EFO_0010736
Diseaseintraocular pressure measurement

DGKG FBN1 FBN2 RXRA

7.07e-04509244EFO_0004695
Diseasetotal cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement

CRTAC1 ZNF507

7.28e-0449242EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Diseasebirth weight, pelvic organ prolapse

FBN2 RXRA

7.28e-0449242EFO_0004344, EFO_0004710
DiseaseL2 Acute Lymphoblastic Leukemia

IKZF1 IKZF2

7.58e-0450242C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

IKZF1 IKZF2

8.20e-0452242C0023452
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2

8.52e-0453242C4707243
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF1 IKZF2

1.13e-0361242C1961102
Diseasetonsillectomy risk measurement

ZNF76 IKZF1 SLC45A4

1.19e-03260243EFO_0007924
Diseaseneutrophil percentage of leukocytes

IKZF1 CPSF4 FBN1 SLC45A4

1.38e-03610244EFO_0007990
Diseasealbumin:globulin ratio measurement

IKZF1 ZFP57

1.61e-0373242EFO_0005128
Diseasebody surface area

DGKG CRTAC1 FBN1 FBN2

1.68e-03643244EFO_0022196
Diseasecentral corneal thickness

FBN1 FBN2 RXRA

1.96e-03309243EFO_0005213

Protein segments in the cluster

PeptideGeneStartEntry
CGKAYSYRSNLCRHK

ZNF354C

501

Q86Y25
CSGARGTCHYFANKY

COL4A6

1636

Q14031
SIYSHQCGRRKGKQY

CAPS2

346

Q9BXY5
SYRCKCTRGYKLSPG

FBN3

1786

Q75N90
GRCYLHQCTGRGAYK

LMLN2

551

A0A1B0GTW7
HKCGYCGRSYKQRSS

IKZF1

201

Q13422
SVGKPHKCNYCGRSY

IKZF2

191

Q9UKS7
HKCNYCGRSYKQRSS

IKZF2

196

Q9UKS7
RKQGLCCTYCKYTVH

DGKG

296

P49619
HMRSTCYGGYKRGQC

FBN1

656

P35555
YGSYRCRTNKKCSRG

CRTAC1

581

Q9NQ79
YKCGEKGHYANRCTK

CPSF4

246

O95639
YYCKCHAGFQRTPTK

FBN2

556

P35556
TGHLCLYCGKLYSRK

PRDM13

571

Q9H4Q3
RSSGKHYGVYSCEGC

RXRA

141

P19793
YGFCYCPGSHKRKRS

GMCL2

41

Q8NEA9
RSSGKHYGVYSCEGC

RXRB

211

P28702
FSGKRHIRYNRCCYK

B3GALT9

291

A8MXE2
GKLGSHCYRYRRANA

SLC45A4

431

Q5BKX6
YKCYECGKGFSRSSH

ZNF436

166

Q9C0F3
CGKCFSRRSYLYSHQ

ZFP57

96

Q9NU63
TYCSQVLGLHCYKKG

TRIM25

496

Q14258
YRCRLCHYTSGNKGY

ZNF507

641

Q8TCN5
RPYKCSECGKSFRYH

ZNF548

391

Q8NEK5
HGGTRLYKCTDCAYS

ZNF142

1446

P52746
YKCDQCGKAYGRSCH

ZNF317

306

Q96PQ6
RCGYKGCGRLYTTAH

ZNF76

166

P36508
CKVCGRGYTSKSYLT

ZNF337

266

Q9Y3M9