Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH4 MYH10 MYO5C MYO15A

1.80e-04381494GO:0000146
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH4 MYH10 DNAH14 MYO5C MYO15A DNAH5

2.59e-041181496GO:0003774
GeneOntologyMolecularFunctioncalmodulin binding

MYH4 MYH10 IQGAP2 RASGRF2 ADCY1 RYR2 MYO5C MYO15A

3.39e-042301498GO:0005516
GeneOntologyMolecularFunctionprotein homodimerization activity

TPR ERBB4 LRRK2 RNF8 HMOX1 TENM2 STAT5B MIXL1 CARD9 CEP135 MAP3K9 MIGA1 BCL10 PDCD10 MTUS2 PML

3.96e-0481514916GO:0042803
GeneOntologyMolecularFunctionGABA receptor binding

ERBB4 TRAK1 JAKMIP1

4.23e-04201493GO:0050811
GeneOntologyBiologicalProcessregulation of organelle organization

TPR SMG1 NES TBC1D9B SWAP70 IQGAP2 VPS13C ENTR1 LRRK2 CCT7 FYCO1 ATG2A CNTROB OSBP KANK1 CEP120 BRCA1 RHPN2 BUB1B CEP135 DLG1 MPHOSPH9 ATM ZW10 PDCD10 PML

2.46e-06134214626GO:0033043
GeneOntologyBiologicalProcessregulation of organelle assembly

TPR TBC1D9B ENTR1 LRRK2 ATG2A CNTROB CEP120 BRCA1 CEP135 MPHOSPH9 ATM

5.14e-0628014611GO:1902115
GeneOntologyBiologicalProcessintracellular transport

TPR SMG1 MYH10 CRACR2A VPS13C ENTR1 LRRK2 BRSK2 PTPN23 FYCO1 SSB GOSR2 CERT1 DENND3 MADD TRAK1 MYO5C OSBP CEP120 BRCA1 CLMN IPO13 ZW10 PDCD10 VPS53 PML UEVLD

5.75e-06149614627GO:0046907
GeneOntologyBiologicalProcessresponse to endoplasmic reticulum stress

RASGRF2 ERO1A LRRK2 BRSK2 CERT1 THBS4 RNFT1 UBXN2A SEL1L2 ALOX5 PML

8.42e-0629514611GO:0034976
GeneOntologyBiologicalProcesscentriole replication

CNTROB CEP120 BRCA1 CEP135 CEP152

2.00e-05471465GO:0007099
GeneOntologyBiologicalProcesscentrosome duplication

CNTROB CEP120 BRCA1 CEP135 CEP152 BRSK1

2.38e-05811466GO:0051298
GeneOntologyBiologicalProcesscentriole assembly

CNTROB CEP120 BRCA1 CEP135 CEP152

3.62e-05531465GO:0098534
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

TBC1D9B ENTR1 PLPPR5 CNTROB TENM2 KANK1 CEP120 CEP135 MPHOSPH9

7.02e-052481469GO:0120032
GeneOntologyBiologicalProcessregulation of cell projection assembly

TBC1D9B ENTR1 PLPPR5 CNTROB TENM2 KANK1 CEP120 CEP135 MPHOSPH9

7.70e-052511469GO:0060491
GeneOntologyBiologicalProcesspositive regulation of protein localization

TPR ERBB4 MYH10 ENTR1 PTPN23 CCT7 OSBP CEP120 BRCA1 CEP135 LRRC8A DLG1 PDCD10 PML

8.09e-0559114614GO:1903829
GeneOntologyBiologicalProcessregulation of protein localization

TPR ERBB4 MYH10 SWAP70 ENTR1 LRRK2 BRSK2 PTPN23 CCT7 MADD OSBP CEP120 BRCA1 CEP135 LRRC8A DLG1 TRIM50 PDCD10 ALOX5 PML

8.37e-05108714620GO:0032880
GeneOntologyBiologicalProcessregulation of establishment of protein localization

TPR MYH10 LRRK2 BRSK2 PTPN23 CCT7 MADD OSBP CEP120 BRCA1 CEP135 LRRC8A TRIM50 PDCD10 ALOX5

8.97e-0567414615GO:0070201
GeneOntologyBiologicalProcesscell projection assembly

MYH10 TBC1D9B ENTR1 TSGA10 PTPN23 PLPPR5 CNTROB TENM2 FSIP2 KANK1 CEP120 CEP135 MPHOSPH9 DNAH5 MTSS2

1.07e-0468514615GO:0030031
GeneOntologyBiologicalProcessregulation of cilium assembly

TBC1D9B ENTR1 CNTROB CEP120 CEP135 MPHOSPH9

1.20e-041081466GO:1902017
GeneOntologyBiologicalProcessestablishment of organelle localization

MYH10 LRRK2 FYCO1 HMOX1 MADD TRAK1 MYO5C CEP120 CLMN DLG1 ATM ZW10 PDCD10

1.39e-0454614613GO:0051656
GeneOntologyBiologicalProcessorganelle localization

MYH10 LRRK2 BRSK2 FYCO1 HMOX1 MADD TRAK1 MYO5C CEP120 CLMN DLG1 ATM ZW10 BRSK1 PDCD10

1.43e-0470314615GO:0051640
GeneOntologyBiologicalProcessdevelopment of secondary male sexual characteristics

STAT5A STAT5B

1.49e-0431462GO:0046544
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization involved in establishment of planar polarity

BRSK2 BRSK1

1.49e-0431462GO:0090176
GeneOntologyBiologicalProcessmitotic cell cycle checkpoint signaling

TPR BRCA1 BUB1B ATM ZW10 BRSK1 PML

1.64e-041631467GO:0007093
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle phase transition

TPR BRCA1 BUB1B DLG1 ATM ZW10 BRSK1 PML

1.71e-042191468GO:1901991
GeneOntologyBiologicalProcessnegative regulation of organelle organization

TPR SWAP70 LRRK2 KANK1 BRCA1 RHPN2 BUB1B MPHOSPH9 ATM ZW10 PML

2.09e-0442114611GO:0010639
GeneOntologyBiologicalProcesspositive regulation of organelle organization

TPR NES SWAP70 ENTR1 CCT7 FYCO1 ATG2A OSBP CEP120 CEP135 DLG1 ATM PML

2.27e-0457414613GO:0010638
GeneOntologyBiologicalProcessregulation of cellular localization

TPR ERBB4 MYH10 SWAP70 ENTR1 LRRK2 BRSK2 PTPN23 CCT7 MADD OSBP CEP120 BRCA1 CEP135 LRRC8A DLG1 TRIM50 PDCD10 ALOX5 PML

3.54e-04121214620GO:0060341
GeneOntologyBiologicalProcessvacuolar transport

VPS13C LRRK2 PTPN23 DENND3 TRAK1 VPS53 UEVLD

3.78e-041871467GO:0007034
GeneOntologyCellularComponentmicrotubule organizing center

WHRN CRACR2A TTLL9 DIS3L ENTR1 BRSK2 TSGA10 PTPN23 CCDC178 CNTROB NEK4 CEP120 BRCA1 BUB1B CEP135 CEP152 MPHOSPH9 ATM BRSK1 MTUS2

9.61e-0691915020GO:0005815
DomainIQ

MYH4 DCAF6 MYH10 IQGAP2 RASGRF2 IQCN MYO5C SCN9A MYO15A

1.55e-08811489SM00015
DomainIQ_motif_EF-hand-BS

MYH4 DCAF6 MYH10 IQGAP2 RASGRF2 IQCN MYO5C SCN9A MYO15A

3.95e-08901489IPR000048
DomainIQ

MYH4 DCAF6 MYH10 IQGAP2 RASGRF2 IQCN MYO5C SCN9A MYO15A

5.27e-08931489PS50096
DomainIQ

MYH4 MYH10 IQGAP2 IQCN MYO5C SCN9A MYO15A

1.48e-06711487PF00612
DomainATM/Tel1

SMG1 ATM

6.24e-0521482IPR015519
DomainMyosin_N

MYH4 MYH10 MYO5C

2.07e-04151483PF02736
DomainMyosin_N

MYH4 MYH10 MYO5C

2.07e-04151483IPR004009
DomainMyosin_head_motor_dom

MYH4 MYH10 MYO5C MYO15A

2.27e-04381484IPR001609
DomainMYOSIN_MOTOR

MYH4 MYH10 MYO5C MYO15A

2.27e-04381484PS51456
DomainMyosin_head

MYH4 MYH10 MYO5C MYO15A

2.27e-04381484PF00063
DomainMYSc

MYH4 MYH10 MYO5C MYO15A

2.27e-04381484SM00242
DomainPrefoldin

TPR FYCO1 CCDC27 CEP135 MPHOSPH9

2.67e-04721485IPR009053
DomainZnf_RING_CS

RNF8 TRIM65 BRCA1 TRIM56 RNFT1 TRIM50 PML

3.24e-041631487IPR017907
DomainMyosin-like_IQ_dom

MYH4 MYH10 MYO5C

4.30e-04191483IPR027401
Domain-

MYH4 MYH10 MYO5C

4.30e-041914834.10.270.10
DomainLRRC8_Pannexin-like

LRRC8D LRRC8A

6.14e-0451482IPR021040
DomainBRO1

PTPN23 RHPN2

6.14e-0451482PF03097
DomainMyosin_S1_N

MYH10 MYO5C

6.14e-0451482IPR008989
DomainBRO1_dom

PTPN23 RHPN2

6.14e-0451482IPR004328
DomainBRO1

PTPN23 RHPN2

6.14e-0451482SM01041
DomainAutophagy-rel_C

VPS13C ATG2A

6.14e-0451482IPR015412
DomainATG_C

VPS13C ATG2A

6.14e-0451482PF09333
DomainBRO1

PTPN23 RHPN2

6.14e-0451482PS51180
DomainPannexin_like

LRRC8D LRRC8A

6.14e-0451482PF12534
DomainFATC

SMG1 ATM

6.14e-0451482PF02260
Domain-

PTPN23 RHPN2

6.14e-04514821.25.40.280
DomaintRNA-bd_arm

FYCO1 TRAK1 CEP152

8.73e-04241483IPR010978
DomainRIH_assoc-dom

RYR2 ITPR2

9.16e-0461482IPR013662
DomainIns145_P3_rec

RYR2 ITPR2

9.16e-0461482PF08709
DomainRIH_assoc

RYR2 ITPR2

9.16e-0461482PF08454
DomainRIH_dom

RYR2 ITPR2

9.16e-0461482IPR000699
DomainIns145_P3_rcpt

RYR2 ITPR2

9.16e-0461482IPR014821
DomainRyanodine_recept-rel

RYR2 ITPR2

9.16e-0461482IPR015925
DomainFAT

SMG1 ATM

9.16e-0461482PS51189
DomainFATC

SMG1 ATM

9.16e-0461482PS51190
Domain-

RYR2 ITPR2

9.16e-04614821.25.10.30
DomainFATC_dom

SMG1 ATM

9.16e-0461482IPR003152
DomainRYDR_ITPR

RYR2 ITPR2

9.16e-0461482PF01365
DomainPIK_FAT

SMG1 ATM

9.16e-0461482IPR014009
DomainFATC

SMG1 ATM

9.16e-0461482SM01343
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

1.28e-0371482IPR012345
DomainSTAT

STAT5A STAT5B

1.28e-0371482IPR001217
DomainSTAT_int

STAT5A STAT5B

1.28e-0371482SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

1.28e-0371482IPR013801
DomainSTAT_bind

STAT5A STAT5B

1.28e-0371482PF02864
DomainSTAT_int

STAT5A STAT5B

1.28e-0371482PF02865
Domain-

STAT5A STAT5B

1.28e-03714821.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

1.28e-0371482PF01017
Domain-

STAT5A STAT5B

1.28e-03714821.20.1050.20
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

1.28e-0371482IPR013799
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

1.28e-0371482IPR015988
Domain-

STAT5A STAT5B

1.28e-03714822.60.40.630
DomainSTAT_TF_alpha

STAT5A STAT5B

1.69e-0381482IPR013800
DomainChorein_N

VPS13C ATG2A

1.69e-0381482PF12624
DomainVPS13_N

VPS13C ATG2A

1.69e-0381482IPR026854
Domainzf-C3HC4

RNF8 TRIM65 BRCA1 TRIM56 RNFT1 TRIM50 PML

2.03e-032231487PF00097
DomainMYTH4

PLEKHH1 MYO15A

2.16e-0391482PS51016
DomainMyTH4

PLEKHH1 MYO15A

2.16e-0391482SM00139
DomainMyTH4_dom

PLEKHH1 MYO15A

2.16e-0391482IPR000857
DomainMyTH4

PLEKHH1 MYO15A

2.16e-0391482PF00784
DomainBBOX

TRIM65 TRIM56 TRIM50 PML

2.20e-03691484SM00336
DomainPH

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP ACAP3

2.36e-032291487PF00169
DomainZnf_C3HC4_RING-type

RNF8 TRIM65 BRCA1 TRIM56 RNFT1 TRIM50

2.51e-031721486IPR018957
Domainzf-B_box

TRIM65 TRIM56 TRIM50 PML

2.57e-03721484PF00643
DomainMIR

RYR2 ITPR2

2.69e-03101482PF02815
DomainMIR_motif

RYR2 ITPR2

2.69e-03101482IPR016093
DomainMIR

RYR2 ITPR2

2.69e-03101482PS50919
DomainMIR

RYR2 ITPR2

2.69e-03101482SM00472
DomainP-loop_NTPase

ABCC3 MYH4 MYH10 LRRK2 IQCN RFC5 SRPRB DNAH14 RHEB MYO5C MTHFD1 SMARCA1 DLG1 MYO15A DNAH5

3.03e-0384814815IPR027417
DomainZF_BBOX

TRIM65 TRIM56 TRIM50 PML

3.76e-03801484PS50119
DomainZnf_B-box

TRIM65 TRIM56 TRIM50 PML

3.93e-03811484IPR000315
DomainI-BAR_dom

ACAP3 MTSS2

4.59e-03131482IPR013606
DomainDynein_heavy_chain_D4_dom

DNAH14 DNAH5

5.33e-03141482IPR024317
DomainDynein_HC_stalk

DNAH14 DNAH5

5.33e-03141482IPR024743
DomainMT

DNAH14 DNAH5

5.33e-03141482PF12777
DomainAAA_8

DNAH14 DNAH5

5.33e-03141482PF12780
DomainFERM_M

PLEKHH1 FRMPD3 MYO15A

5.77e-03461483PF00373
DomainDHC_fam

DNAH14 DNAH5

6.12e-03151482IPR026983
DomainuDENN

DENND3 MADD

6.12e-03151482PF03456
DomainDynein_heavy

DNAH14 DNAH5

6.12e-03151482PF03028
DomainPI3/4_kinase_CS

SMG1 ATM

6.12e-03151482IPR018936
DomainDynein_heavy_dom

DNAH14 DNAH5

6.12e-03151482IPR004273
DomainPH

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP ACAP3

6.77e-032781487SM00233
DomainFERM_central

PLEKHH1 FRMPD3 MYO15A

6.88e-03491483IPR019748
DomainFERM_domain

PLEKHH1 FRMPD3 MYO15A

6.88e-03491483IPR000299
DomainPH_DOMAIN

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP ACAP3

6.90e-032791487PS50003
DomainPH_dom-like

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP FRMPD3 ACAP3 ANKS1A

6.95e-034261489IPR011993
DomainDENN

DENND3 MADD

6.96e-03161482SM00799
Domain-

SMG1 ATM

6.96e-031614821.10.1070.11
DomainDENN

DENND3 MADD

6.96e-03161482PF02141
DomaindDENN

DENND3 MADD

6.96e-03161482PF03455
DomainPI3Kc

SMG1 ATM

6.96e-03161482SM00146
DomainUDENN

DENND3 MADD

6.96e-03161482PS50946
DomainDDENN

DENND3 MADD

6.96e-03161482PS50947
DomaindDENN

DENND3 MADD

6.96e-03161482SM00801
DomaindDENN_dom

DENND3 MADD

6.96e-03161482IPR005112
DomainuDENN_dom

DENND3 MADD

6.96e-03161482IPR005113
DomainDENN

DENND3 MADD

6.96e-03161482PS50211
DomainDENN_dom

DENND3 MADD

6.96e-03161482IPR001194
DomainPH_domain

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP ACAP3

7.03e-032801487IPR001849
Pubmed

The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.

STAT5A STAT5B ATM

8.51e-083154323593005
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

WHRN DSCAM LRRK2 PLPPR5 HMOX1 RFC5 DENND3 RYR2 CCDC27 RHPN2 CARD9 RNFT1 UBXN2A CEP152 MYO15A MTUS2 ANKS1A

1.40e-078141541723251661
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

TPR FGFR1OP2 ERBB4 MYH10 BRSK2 CCT7 TENM2 SRPRB RYR2 MADD RHEB OSBP SUGP2 MTHFD1 ELFN1 SNX25 FBXO41 DLG1 CRYBG3 ADGRL3

1.71e-0711391542036417873
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MYH4 MYH10 EPPK1 IQGAP2 RASGRF2 ENTR1 PSMB3 SSB RFC5 SRPRB LIG3 IGF2BP2 RHPN2 MTHFD1 FANCI CEP135 BCL10 ZW10 PDCD10 TCEAL9 ANKS1A

2.64e-0712841542117353931
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NES ERBB4 BRSK2 MADD TRAK1 NEK4 FSIP2 CLMN BUB1B MAP3K9 CEP152 MPHOSPH9 CRYBG3 R3HDM1 PML MTSS2 ANKS1A

3.08e-078611541736931259
Pubmed

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

NES MYH10 EPPK1 ERO1A MED14 FYCO1 HMOX1 RFC5 SRPRB ITPR2 LIG3 MTHFD1 JAKMIP1

4.26e-075031541336217030
Pubmed

BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.

RNF8 BCL10 ATM

8.46e-075154324732096
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NES VPS13C ERO1A ENTR1 HMOX1 MADD ITPR2 NEK4 KANK1 CLMN CEP135 DLG1 MPHOSPH9 R3HDM1 ANKS1A

1.02e-067331541534672954
Pubmed

Human transcription factor protein interaction networks.

SMG1 MYH10 DIS3L ENTR1 PSMB3 CCT7 SSB STAT5A STAT5B MYO5C RLF LIG3 ANGPTL6 IGF2BP2 BRCA1 SUGP2 SMARCA1 CEP152 R3HDM1 TAF1L PML

1.47e-0614291542135140242
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SMG1 MYH10 TBC1D9B IQGAP2 ERO1A PSMB3 CCT7 SSB RFC5 GOSR2 SRPRB ITPR2 LIG3 IGF2BP2 FANCI BUB1B IPO13 ATM ZW10 VPS53 PML

1.66e-0614401542130833792
Pubmed

Mammalian SAD kinases are required for neuronal polarization.

NES BRSK2 BRSK1

1.69e-066154315705853
Pubmed

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

CARD9 BCL10 ATM

1.69e-066154324777530
Pubmed

CEP295 interacts with microtubules and is required for centriole elongation.

CNTROB CEP120 CEP135

4.69e-068154327185865
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

RNMT LRRC8D TRAK1 IGF2BP2 KANK1 SUGP2 MTHFD1 RCL1 LRRC8A DLG1 CEP152 MPHOSPH9

5.25e-065361541215840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

RNMT LRRC8D TRAK1 IGF2BP2 KANK1 SUGP2 MTHFD1 RCL1 LRRC8A DLG1 CEP152 MPHOSPH9

5.45e-065381541210512203
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

TPR ERO1A FYCO1 HMOX1 ITPR2 IGF2BP2 MTHFD1 FANCI CEP135

5.51e-06285154932838362
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

TBC1D9B ENTR1 PTPN23 CCT7 RFC5 POLR3C FANCI PDCD10 VPS53

6.00e-06288154923383273
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TPR NES MYH10 DSCAM IQGAP2 FYCO1 TENM2 RHEB FBXO41 DLG1 JAKMIP1 FRMPD3 BRSK1 SH3BP5 MTSS2 ANKS1A

6.38e-069631541628671696
Pubmed

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

BRCA1 FANCI ATM

9.99e-0610154317478428
Pubmed

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.

TPR DCAF6 SSB LIG3 IGF2BP2 CEP135

1.36e-05116154621282530
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WHRN MYH10 TENM2 MADD TRAK1 PLEKHH1 KANK1 SUGP2 R3HDM1 ADGRL3

1.48e-054071541012693553
Pubmed

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.

RNF8 TRIM65 BRCA1 TRIM56 RNFT1 PML

1.50e-05118154619690564
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TPR FAM193B MYH10 PSMB3 PTPN23 CCT7 RHEB LIG3 IGF2BP2 SUGP2 MTHFD1 CLMN BUB1B PML ANKS1A

1.87e-059341541533916271
Pubmed

Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.

CERT1 OSBP

1.95e-052154221285358
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

1.95e-052154223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

1.95e-052154226999798
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

1.95e-052154231443474
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

1.95e-052154212377952
Pubmed

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity.

BRCA1 ATM

1.95e-052154221849032
Pubmed

SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.

SMG1 ATM

1.95e-052154231565865
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

1.95e-052154221127177
Pubmed

Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.

ERBB4 BRCA1

1.95e-052154216914727
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

1.95e-052154216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

1.95e-052154225552366
Pubmed

Constitutive activation of the ATM/BRCA1 pathway prevents DNA damage-induced apoptosis in 5-azacytidine-resistant cell lines.

BRCA1 ATM

1.95e-052154224680865
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

1.95e-052154225470773
Pubmed

Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer.

HMOX1 BRCA1

1.95e-052154226227317
Pubmed

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.

WHRN MYO15A

1.95e-052154215590699
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

1.95e-052154221431790
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

1.95e-052154228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

1.95e-052154221826656
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

1.95e-05215427720707
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

1.95e-052154227264955
Pubmed

Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.

NES BRCA1

1.95e-052154228439082
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

1.95e-052154222159083
Pubmed

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.

SMG1 ATM

1.95e-052154218332866
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

1.95e-052154220008792
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

1.95e-052154233199496
Pubmed

Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.

WHRN MYO15A

1.95e-052154217619105
Pubmed

CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.

CARD9 BCL10

1.95e-052154211053425
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

1.95e-052154216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

1.95e-052154212217382
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

1.95e-052154231599926
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

1.95e-052154210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

1.95e-052154221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

1.95e-052154210486277
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

1.95e-052154216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

1.95e-052154215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

1.95e-052154230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

1.95e-052154223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

1.95e-052154232790723
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

1.95e-052154218492722
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

1.95e-052154210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

1.95e-052154210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

1.95e-052154235464049
Pubmed

Mitochondrial calcium overload is a key determinant in heart failure.

RYR2 ITPR2

1.95e-052154226217001
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

1.95e-052154218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

1.95e-052154223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

1.95e-05215428631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

1.95e-052154211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

1.95e-052154224878107
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

1.95e-052154212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

1.95e-052154212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

1.95e-05215427568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

1.95e-052154224497979
Pubmed

Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1.

BRCA1 ATM

1.95e-052154219996295
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

1.95e-052154217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

1.95e-052154217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

1.95e-052154217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

1.95e-052154210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

1.95e-052154217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

1.95e-052154224497923
Pubmed

Comparison of collagen propeptides as growth markers in children with inflammatory bowel disease.

BRCA1 ATM

1.95e-05215422001833
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

1.95e-052154224335105
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

1.95e-052154229460051
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

1.95e-052154228606561
Pubmed

ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.

ERBB4 STAT5A

1.95e-052154215863494
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

1.95e-052154212393407
Pubmed

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

STAT5A STAT5B

1.95e-052154212039059
Pubmed

Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

BRSK2 BRSK1

1.95e-052154230307479
Pubmed

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.

STAT5A STAT5B

1.95e-052154221178171
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

1.95e-052154220233708
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

1.95e-052154216775227
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

1.95e-052154217447893
Pubmed

Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.

ABCC3 ITPR2

1.95e-052154220578149
Pubmed

Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing.

HMOX1 ALOX5

1.95e-052154224226420
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

1.95e-052154216115927
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

1.95e-052154223275557
Pubmed

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.

RYR2 ITPR2

1.95e-052154228158491
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

1.95e-052154211867689
InteractionCEP120 interactions

EPPK1 ENTR1 CNTROB CEP120 FANCI CEP135 CEP152 MPHOSPH9

1.41e-061061528int:CEP120
InteractionZYX interactions

IQGAP2 RASGRF2 ENTR1 PTPN23 CNTROB NEK4 CLMN BUB1B CEP152 MPHOSPH9 CRYBG3 PML

7.75e-0632915212int:ZYX
InteractionTNRC6B interactions

ENTR1 PTPN23 TRIM65 CNTROB IGF2BP2 CEP120 BRCA1 CEP135 CEP152 MPHOSPH9 PML

1.00e-0528215211int:TNRC6B
InteractionCPAP interactions

FGFR1OP2 ENTR1 RFC5 STAT5A STAT5B CEP120 CEP135 CEP152 MPHOSPH9

1.02e-051821529int:CPAP
InteractionKIAA1328 interactions

TSGA10 ZGPAT CARD9 CEP135 ANKS1A

1.55e-05421525int:KIAA1328
InteractionMAD1L1 interactions

TPR TSGA10 RNF8 STAT5B LGALSL ZW10 ALOX5 PML

1.85e-051501528int:MAD1L1
InteractionRGPD3 interactions

FGFR1OP2 ESRP1 NEK4 CEP152 PML

2.71e-05471525int:RGPD3
InteractionALMS1 interactions

ENTR1 PTPN23 CNTROB ZHX1-C8orf76 CEP120 BRCA1 CEP135 CEP152

3.52e-051641528int:ALMS1
InteractionZNF426 interactions

TSGA10 RFC5 ZGPAT CARD9 MTUS2

5.36e-05541525int:ZNF426
InteractionTRIM29 interactions

CRACR2A TSGA10 RNF8 RFC5 BRCA1 CARD9 ATM MTUS2 ANKS1A

6.63e-052311529int:TRIM29
InteractionCENPI interactions

CENPN RNF8 BRCA1 BUB1B ZW10

8.24e-05591525int:CENPI
InteractionKRT18 interactions

NES EPPK1 ERO1A ENTR1 CNTROB MYO5C BRCA1 RHPN2 CEP152 MPHOSPH9 CRYBG3 PML

8.26e-0541915212int:KRT18
InteractionCEP57L1 interactions

TSGA10 ZGPAT BRCA1 CARD9 ALOX5 MTUS2

8.34e-05951526int:CEP57L1
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SWAP70 RASGRF2 VEPH1 CERT1 PLEKHH1 OSBP ACAP3

1.38e-04206997682
GeneFamilyVolume regulated anion channel subunits

LRRC8D LRRC8A

2.94e-0459921158
GeneFamilyRing finger proteins

RNF8 TRIM65 BRCA1 TRIM56 RNFT1 TRIM50 PML

7.89e-0427599758
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM65 TRIM56 TRIM50 PML

1.84e-039599459
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PLEKHH1 FRMPD3 MYO15A

2.59e-03509931293
GeneFamilyMyosin heavy chains

MYH4 MYH10

2.98e-03159921098
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CCPG1 DSCAM LRRK2 BRSK2 CERT1 TENM2 ADCY1 RYR2 FSIP2 SUGP2 SCN9A MAP3K9 FRMPD3 R3HDM1 GOLGA7B VPS53 MTUS2 ADGRL3 CCDC144A SH3BP5

7.27e-06110615320M39071
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 KANK1 HOXD10 CLMN ELFN1 TRIM50 CRYBG3

1.19e-081771549c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25 DNAH5

2.42e-081921549efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25 DNAH5

2.76e-0819515499406866f99555198a9be311fbd65751b70f35446
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25 DNAH5

2.86e-0718615482ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

RASGRF2 ITPR2 IGF2BP2 KANK1 BRCA1 DLG1 MPHOSPH9 R3HDM1

2.86e-071861548de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

RASGRF2 ITPR2 IGF2BP2 KANK1 BRCA1 DLG1 MPHOSPH9 R3HDM1

2.86e-0718615480b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

ERBB4 VEPH1 LRRK2 DNAH14 MYO5C KANK1 SNX25 DNAH5

3.10e-071881548707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 MYO5C KANK1 HOXD10 TRIM50

3.23e-071891548975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 MYO5C KANK1 HOXD10 TRIM50

3.23e-0718915487eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25

3.50e-071911548276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25

3.50e-071911548e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25

3.64e-071921548499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 DNAH14 MYO5C KANK1 SNX25 DNAH5

3.64e-071921548cc9911e182a289779a2612bc213daae5607689e7
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 DNAH14 MYO5C KANK1 SNX25 DNAH5

3.64e-07192154806013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 TSGA10 CCDC178 DNAH14 IGF2BP2 KANK1 RHPN2 CLMN

3.94e-0719415485eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1 SNX25

4.78e-071991548725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RNMT DSCAM RASGRF2 CNTROB TENM2 POLR3C THBS4 VPS53

4.96e-07200154824e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC1 ERBB4 VEPH1 ESRP1 MYO5C BRSK1 DNAH5

2.08e-06169154730141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell(05)_Ciliated-(3)_72hpi|(05)_Ciliated / shred by cell type and Timepoint

WHRN MYH4 PLVAP CENPN CNTROB DENND3

2.72e-061131546eaa5bc8f8183b353ee1e7618e99220eb3684cd60
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 KANK1 HOXD10 CLMN

3.04e-061791547666072c0e8448dbaec1683d18368ec2502453f90
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

ERBB4 VEPH1 LRRK2 ESRP1 MYO5C KANK1 SNX25

3.65e-061841547369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES CNNM2 TENM2 ADCY1 RYR2 PPP1R3A KANK1

3.92e-0618615474780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 MYO5C KANK1 DNAH5

4.06e-06187154781cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 ESRP1 CCDC178 MYO5C IGF2BP2 MTUS2

4.06e-06187154777886f99c229610abd28c4c370d2c7d1536c9782
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

ERBB4 VEPH1 ESRP1 MYO5C KANK1 SNX25 DNAH5

4.21e-061881547c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

ERBB4 EPPK1 LRRK2 DNAH14 KANK1 SCN9A DNAH5

4.21e-061881547ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERBB4 VEPH1 LRRK2 ESRP1 MYO5C KANK1 SNX25

4.51e-06190154727a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 ERBB4 LRRK2 ESRP1 CCDC178 DNAH14 DNAH5

4.51e-0619015473fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

WHRN LRRK2 TENM2 ITPR2 RASSF6 CLMN PDE7B

4.51e-0619015471bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 MYO5C KANK1 SNX25

4.67e-061911547a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPM6 VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

4.67e-0619115475f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1

4.67e-061911547ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

ERBB4 DSCAM VEPH1 LRRK2 DNAH14 MYO5C KANK1

4.67e-061911547d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TRPM6 VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

4.67e-0619115472f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 MYO5C KANK1 SNX25

4.83e-06192154758c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

WHRN LRRK2 TENM2 ITPR2 RASSF6 CLMN SCN9A

4.83e-06192154725460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DNAH14 ITPR2 IGF2BP2 KANK1 RHPN2 DLG1 MTSS2

5.00e-061931547503a979328c68b096680b71359a26f02fafdff35
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB4 VEPH1 LRRK2 ESRP1 DNAH14 MYO5C KANK1

5.00e-061931547a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ERBB4 VEPH1 LRRK2 DNAH14 MYO5C KANK1 SNX25

5.17e-06194154753f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 VEPH1 LRRK2 TSGA10 DNAH14 KANK1 RHPN2

5.53e-0619615476ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RNMT VPS13C VEPH1 ESRP1 TSGA10 MYO5C DNAH5

5.72e-061971547b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell(11)_FOXN4+|World / shred by cell type by condition

CEP120 BRCA1 CLMN FANCI CEP135 CEP152 CCDC171

5.91e-061981547516b1acdf997dd8debc3dca066519366e507b414
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 VEPH1 ESRP1 DNAH14 MYO5C KANK1 SNX25

6.11e-0619915475f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 VEPH1 ESRP1 DNAH14 MYO5C KANK1 SNX25

6.11e-0619915478587bd98de7767a575088afbea07a1feb4516b9b
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 VEPH1 ESRP1 DNAH14 MYO5C KANK1 SNX25

6.11e-0619915475cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ERBB4 DSCAM LRRK2 THBS4 KANK1 SCN9A PDE7B

6.11e-06199154719a97e27a4758e794ce7246d295e112b47931a48
ToppCellTransverse-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

CRACR2A LRRK2 TRIM65 FYCO1 BRCA1 BUB1B CCDC171

6.11e-061991547170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 CRACR2A ESRP1 MYO5C IGF2BP2 RHPN2 CLMN

6.31e-062001547d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells-Neuroepithelial_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

CENPN MYO5C KANK1 FANCI BUB1B CEP152 ZW10

6.31e-062001547c9c832f489629b8724501ddfede984b41a7b674d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells|GW23 / Sample Type, Dataset, Time_group, and Cell type.

CENPN MYO5C KANK1 FANCI BUB1B CEP152 ZW10

6.31e-062001547d7832ab1ed0ff0a6f7e3ac11b2095dc72c90af44
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CENPN LIG3 TRIM56 BUB1B CEP135 MPHOSPH9

1.34e-05149154665778f19599b4955c0a16f0121237656449431fb
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytotoxic_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EPPK1 LIG3 RHPN2 RCL1 MAP3K9 PDE7B

1.55e-051531546df2130689e53748e820a5835fa396fe82a5d2c7c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 CNNM2 TRAK1 HOXD10 CLMN TRIM50

1.87e-0515815467960337d87afecf2692ab65e5991f052ceddfacc
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

DSCAM TENM2 RYR2 SEL1L2 MTUS2 ADGRL3

1.93e-0515915465335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRAK1 MYO5C RASSF6 CLMN LRRC8A ALOX5

2.15e-05162154680619a93c57fe16daf91dc571874ef9ac888953d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

NES PLVAP RASGRF2 CCDC178 ADCY1 ADGRL3

2.22e-051631546977a970b1296234c22178420294cea73506ee02f
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

ST6GALNAC1 ERBB4 VEPH1 LRRK2 ZGPAT DNAH5

2.22e-051631546e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCelldroplet-Marrow-BM-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSCAM LRRC8D MOSPD1 LIG3 RHPN2 ACAP3

2.30e-051641546b77995958c938e10a526118f75d78cee72e0b207
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC1 ERBB4 VEPH1 ESRP1 BRSK1 DNAH5

2.55e-051671546cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellControl|World / group, cell type (main and fine annotations)

ERBB4 VEPH1 IQCN MYO5C KANK1 SNX25

2.64e-051681546a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 ESRP1 MYO5C FANCI SNX25 TCEAL9

2.82e-0517015464ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

SWAP70 FYCO1 STAT5A TRIM56 DNAH5 OPLAH

2.91e-05171154674be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RASGRF2 ITPR2 THBS4 SCN9A MTUS2 ADGRL3

3.31e-051751546a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 HOXD10 TRIM50

3.31e-051751546787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCellNS-critical-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC178 CEP120 BRCA1 FANCI CEP152 CCDC171

3.42e-0517615467cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

ERBB4 RASGRF2 RGS8 ELFN1 UBXN2A MTSS2

4.13e-051821546b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ABCC3 ERBB4 ESRP1 MYO5C RASSF6 SCN9A

4.25e-051831546c5b10571599dc26476170b54b53f09c23e6b3117
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 CNNM2 ESRP1 UROC1 HOXD10 RASSF6

4.25e-051831546f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPN BRCA1 CLMN FANCI BUB1B ALOX5

4.25e-05183154642dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 KANK1 CLMN

4.25e-0518315462e831a4d99c6f983793df71c0994124c943c6da9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 MYH10 LRRK2 MYO5C CLMN MTUS2

4.39e-051841546d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM6 CNNM2 ESRP1 UROC1 HOXD10 RASSF6

4.39e-0518415468939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ITPR2 IGF2BP2 KANK1 CLMN DLG1 TRIM50

4.52e-0518515461d874608aa2062024323512f68889219471b2f00
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCAF6 DSCAM DENND3 RYR2 DLG1 R3HDM1

4.66e-05186154684ba666237c18189d7e7556bd92dd953af733c00
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 VEPH1 CCDC178 TRAK1 HOXD10

4.66e-05186154608632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES CNNM2 TENM2 ADCY1 RYR2 KANK1

4.66e-051861546a95744b8649096bd7cfc3591a02841fa411085b3
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

IQGAP2 RASGRF2 ITPR2 KANK1 CLMN TRIM50

4.80e-051871546f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 ESRP1 CCDC178 MYO5C IGF2BP2

4.80e-051871546f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

TRPM6 ERBB4 CNNM2 CCDC178 HOXD10 CLMN

4.94e-051881546df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

4.94e-0518815467499e353ea5853d06558b20cedee3c7910425d7d
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

4.94e-051881546562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES CNNM2 TENM2 ADCY1 RYR2 KANK1

5.09e-051891546975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB4 ADCY1 RYR2 PPP1R3A GOLGA7B MTUS2

5.09e-051891546e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 ESRP1 CCDC178 MYO5C IGF2BP2

5.09e-051891546e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellfacs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB4 ADCY1 RYR2 PPP1R3A GOLGA7B MTUS2

5.09e-051891546b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

5.24e-0519015468ff8c586237cf15f930416710bcff45205fe6f70
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 ERBB4 CNNM2 CCDC178 CLMN TRIM50

5.24e-051901546b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellPND07-Epithelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 ESRP1 MYO5C MTHFD1 SNX25 TCEAL9

5.24e-051901546e3a2c8b637f60c963520dffe99c526809d818cab
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CEP120 BRCA1 CLMN FANCI CEP152 CCDC171

5.24e-051901546250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RFC5 BRCA1 FANCI BUB1B CEP152 MPHOSPH9

5.24e-051901546d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR FGFR1OP2 VPS13C ITPR2 UBXN2A R3HDM1

5.40e-05191154660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 LRRK2 DNAH14 KANK1 DNAH5 ADGRL3

5.40e-051911546d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ABCC3 ERBB4 ESRP1 MYO5C SCN9A DNAH5

5.40e-05191154660ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 ESRP1 TENM2 MYO5C RASSF6 SCN9A

5.40e-05191154605731ece7867659c662f952812805f947032fe10
ToppCell367C-Epithelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

ST6GALNAC1 VEPH1 LRRK2 ESRP1 SNX25 DNAH5

5.40e-051911546d31975fc33779b0b3ff1a50d7c64fec8d08be4d4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 ERBB4 ESRP1 CCDC178 CLMN DNAH5

5.40e-0519115465a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC3 ERBB4 ESRP1 CCDC178 CLMN DNAH5

5.40e-05191154655ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VEPH1 MYO5C MTHFD1 CLMN SNX25 TCEAL9

5.40e-0519115464ab3056f9af2a6caed39f32288562f480811cd7b
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR FGFR1OP2 VPS13C ITPR2 UBXN2A R3HDM1

5.40e-051911546973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VEPH1 LRRK2 ESRP1 DNAH14 KANK1 SNX25

5.55e-051921546fb2f0e897228f808d9ff734ad05e9b49dc38fa50
DiseaseT-Cell Prolymphocytic Leukemia

STAT5B ATM

2.50e-0521482C2363142
Diseaseserine/threonine-protein kinase BRSK2 measurement

BRSK2 BRSK1

7.47e-0531482EFO_0803063
Diseasesmoking cessation

CNNM2 VEPH1 HMOX1 TENM2 PPP1R3A ZGPAT UBXN2A ANKS1A

2.47e-043251488EFO_0004319
Diseaseheroin dependence

MYH10 BRSK2

5.16e-0471482EFO_0004240
Diseasefemale breast cancer (is_implicated_in)

FANCI ATM

6.86e-0481482DOID:0050671 (is_implicated_in)
Diseasemanic episode measurement, depressive episode measurement

WHRN RNLS

8.79e-0491482EFO_0007704, EFO_0007705
Diseasefeeling nervous measurement

CNNM2 DSCAM DNAH14 MADD

9.79e-04871484EFO_0009597
Diseasecoronary artery disease

ERBB4 CNNM2 RNLS DSCAM SWAP70 TRIM65 GOSR2 CERT1 IGF2BP2 CEP120 ELFN1 CEP135 JAKMIP1 ADGRL3 ANKS1A

1.01e-03119414815EFO_0001645
DiseaseFanconi anemia (is_implicated_in)

BRCA1 FANCI

1.10e-03101482DOID:13636 (is_implicated_in)
Diseaseacute insulin response measurement

IGF2BP2 CARD9

1.33e-03111482EFO_0006831
DiseaseGastric Adenocarcinoma

MAP3K9 ATM BRSK1

1.50e-03451483C0278701
DiseaseSchizophrenia

ST6GALNAC1 ERBB4 CNNM2 HMOX1 TRAK1 IGF2BP2 BRCA1 MTHFD1 DLG1 ATM PDE7B PML

1.70e-0388314812C0036341
DiseaseHereditary Motor and Sensory-Neuropathy Type II

HOXD10 SCN9A

1.88e-03131482C0270914
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

WHRN ADCY1 MYO15A

2.16e-03511483cv:CN043650
DiseaseTesticular Germ Cell Tumor

BCL10 ALOX5

2.19e-03141482C1336708
Diseasepancreatic cancer (is_implicated_in)

LIG3 BRCA1 ATM ALOX5

2.48e-031121484DOID:1793 (is_implicated_in)
DiseaseAutosomal recessive primary microcephaly

CEP135 CEP152

2.51e-03151482cv:C3711387
Diseaseunipolar depression, cognitive function measurement

DCAF6 MYH10

2.51e-03151482EFO_0003761, EFO_0008354
Diseasealcohol use disorder (implicated_via_orthology)

ERBB4 ADCY1 RYR2 MADD ANGPTL6

3.09e-031951485DOID:1574 (implicated_via_orthology)
DiseaseAlzheimer disease

TENM2 DENND3 CLMN TRIM56 MYO15A CCDC171 PDE7B MTSS2

3.20e-034851488MONDO_0004975
Diseasecolorectal cancer (is_implicated_in)

ERBB4 BRCA1 BUB1B ATM

3.28e-031211484DOID:9256 (is_implicated_in)
Diseasekidney volume

HOXD10 CCDC171

3.63e-03181482EFO_0600044
DiseaseCCL2 measurement

WHRN CRACR2A FYCO1 CARD9

3.79e-031261484EFO_0004749
DiseaseAdenocarcinoma of lung (disorder)

TRPM6 RCL1 ATM TAF1L ALOX5

3.90e-032061485C0152013
Diseaseportal hypertension (implicated_via_orthology)

HMOX1 ALOX5

4.04e-03191482DOID:10762 (implicated_via_orthology)
DiseasePancreatic carcinoma

BRCA1 ALOX5

4.04e-03191482C0235974
Diseaseurate measurement, bone density

TRPM6 ERBB4 CRACR2A DSCAM TENM2 DNAH14 ITPR2 FSIP2 SEL1L2

4.14e-036191489EFO_0003923, EFO_0004531
Diseasebrain connectivity measurement

ERBB4 CNNM2 RNMT RNLS BRSK2 LRRC8A MTUS2

4.17e-034001487EFO_0005210
DiseaseBRCAX breast cancer

ITPR2 PDE7B

4.47e-03201482EFO_0009443
DiseaseAdenocarcinoma of prostate

BRCA1 ATM

4.47e-03201482C0007112
Diseaseenergy intake

TENM2 DENND3 KANK1 MTUS2

4.71e-031341484EFO_0003939
DiseaseBREAST CANCER

BRCA1 ATM

4.93e-03211482114480
Diseasediabetic retinopathy

VPS13C VEPH1 TENM2 UBXN2A

4.97e-031361484EFO_0003770

Protein segments in the cluster

PeptideGeneStartEntry
FQARVSRQTLLALEK

BUB1B

196

O60566
KIRLEDTNQENFTRI

C2orf15

46

Q8WU43
TTQKRRQDFLDILLS

CYP4Z2P

276

Q8N1L4
TLFSTINQRIVIRDN

ERBB4

476

Q15303
QKETELQTCLDQSRR

CEP152

1011

O94986
VSRLTKAQEEIRLTN

ELFN1

356

P0C7U0
NNKTETEDRRTLVLN

CRYBG3

1461

Q68DQ2
QKATQDFQRATEVLR

SH3BP5

116

O60239
ESKFNSEIIQLRIRD

CCDC171

296

Q6TFL3
RSSIERVINIFQSNL

DLG1

31

Q12959
NKERTRNIVKFDLRT

ADGRL3

221

Q9HAR2
RSVRQQLQSFVKEDV

ACAP3

101

Q96P50
TERFQARSQELEQKL

CRACR2A

256

Q9BSW2
QERQKISGLRTLEQS

ANKS1A

686

Q92625
IFNRKLADEVITRNE

DCAF6

796

Q58WW2
TTLQLLVSIFRDVKN

DENND3

361

A2RUS2
EQANTIFSLRKDLRQ

CARD9

296

Q9H257
LEVRDRLASSQINKF

ATG2A

1526

Q2TAZ0
RLERLRNKIIQATFS

CCDC27

581

Q2M243
LFRSTAAEVQQVLNR

ESRP1

401

Q6NXG1
DLKARIDQNTVVTRQ

MTUS2

1286

Q5JR59
NRIVDSARSILNKFI

RCL1

206

Q9Y2P8
SSTQQRRQIFRVNKD

R3HDM1

321

Q15032
INEKTFITREQLNSL

RASSF6

46

Q6ZTQ3
RLRAVVESQAFKNIL

IQCN

81

Q9H0B3
ERVLSLQFRDQSLKR

PTPN23

1331

Q9H3S7
NGTITQNERRFVTKL

ITPR2

461

Q14571
SVSLKRIQQFLSQEE

ABCC3

596

O15438
LATDVQTVAQRLKFR

PSMB3

56

P49720
AVFLSEVSENKLRQL

LRRC8A

391

Q8IWT6
TFRDILCRQVDTLQK

CERT1

166

Q9Y5P4
RFQDQVLDLLKTSVV

FANCI

321

Q9NVI1
KRTALRTNQERLLFV

KLHL36

286

Q8N4N3
ELKAVFTDRQLLRNS

LGALSL

86

Q3ZCW2
ESEQLRVFVLSKLNR

MADD

971

Q8WXG6
NRLNRLTTDFNVIVE

SSB

56

P05455
TTVLSNLKIRFERNL

MYO15A

1236

Q9UKN7
QEVRSLTRQLQFLET

FYCO1

506

Q9BQS8
RIERQLFEETVKTLN

GOLGA7B

46

Q2TAP0
NTVEDIQIDNFRRKS

LINC02872

66

A2RU37
RFKRVVETIQAQLLS

BRSK2

621

Q8IWQ3
FRVLLAVRQKTLQDT

CCDC178

731

Q5BJE1
RDTQKDISRVNFNDI

FSIP2

4491

Q5CZC0
INDRVRFLQTIKDIA

PDCD10

121

Q9BUL8
QLATRDFENQEKTIL

PLPPR5

91

Q32ZL2
SRQTQLALEEKAVLR

PLVAP

341

Q9BX97
RSIETKLRQFTNALL

MTSS2

86

Q765P7
ATDINRQNEFLTRLK

PDE7B

281

Q9NP56
DLKTQNVFLTRTNII

NEK4

131

P51957
FTAIAKLLTRQLENT

VEPH1

356

Q14D04
TSRVRTLENKNNLLE

MPHOSPH9

506

Q99550
VIDKFRLQVSEQSQR

MOSPD1

91

Q9UJG1
QERLRATEKFQLAVE

NES

251

P48681
TVEQSTQRIKEFRQL

KANK1

356

Q14678
RKTIINESLNFKIRD

LRRK2

1501

Q5S007
QQERQREELLSRTFT

GOSR2

96

O14653
DVRRFQLKIAELNSV

JAKMIP1

286

Q96N16
FASQTAQRKIREIVQ

IGF2BP2

566

Q9Y6M1
FKASRNLQDVVERVL

LIG3

441

P49916
KQVNERATLFRITSN

OSBP

256

P22059
RKIEIVQFASRTRQL

MED14

81

O60244
FSENRDLRQVQELSK

PPP1R3A

876

Q16821
KENQTAVDVFRRIIL

RHEB

151

Q15382
NKGLREILQITRESF

FGFR1OP2

211

Q9NVK5
ISRNNIRENVFKEAS

BRCA1

1026

P38398
SSVNQLKETLVNRDR

CEP135

776

Q66GS9
VELSILARTFKNTQL

ATM

2256

Q13315
VRILTERSQRKAFLQ

ADCY1

231

Q08828
LTELERKLTFEQQRS

CCPG1

431

Q9ULG6
KREQQLASVESELQR

CEP120

721

Q8N960
RVNSFLSSRLQEIKN

FAM193B

546

Q96PV7
LRRKLNEVQSFSEAQ

ENTR1

281

Q96C92
FIVRSEAQRQELLAK

FRMPD3

1711

Q5JV73
KIRISTQQAETLQDF

DIS3L

376

Q8TF46
TLVESIRREKTQNFL

BCL10

81

O95999
ELTGQFRNRVINTKS

C7

146

P10643
RLEISKSVNLTDRQV

HOXD10

296

P28358
DVKFRELAQLVTQQS

ANGPTL6

161

Q8NI99
ILQRALKNVTVSFRE

CENPN

111

Q96H22
RFKRVVETIQAQLLS

BRSK1

701

Q8TDC3
LTNKIRVIFEVDNLS

DNAH14

1606

Q0VDD8
STSVKELENFRNLLQ

ERO1A

451

Q96HE7
AREASAKLRLQQFIE

FBXO41

316

Q8TF61
LQEVGLEKRSQSRIF

RNMT

156

O43148
RQRVIEEAKTAFLLN

HMOX1

196

P09601
QTARDLKLDFQRTRQ

CCDC144A

931

A2RUR9
NQFLKVDVSRISERQ

RYR2

1601

Q92736
EQKDTFSQQILRERV

IPO13

921

O94829
QRVLDTNDRFLRKIT

MTHFD1

531

P11586
ISQTIENVRQEAKLF

MAP3K9

181

P80192
NDRFRKTTLQVDTLN

MYH10

1756

P35580
RSKQQETVTRLEQSL

CNTROB

271

Q8N137
KLRQFSDVLDQISRN

DNAH5

3951

Q8TE73
KSNNIRTIEEIISFQ

LRRC8D

666

Q7L1W4
IRQAFQVILSESANR

MIGA1

391

Q8NAN2
QELFASINTTRVRLN

DSCAM

1481

O60469
VNIDFQTREATRKNL

RGS8

121

P57771
QLEKELNTLRVTRSA

SRPRB

196

Q9Y5M8
ITEAISSVQKLRQFL

TIGD6

466

Q17RP2
EFQRRCNTLISLIEK

SMARCA1

1011

P28370
VNNLSSEVKERRIVL

RNF8

461

O76064
VRFTIAINTKAREQL

ALOX5

401

P09917
TQDAQNALRRVIEKF

RFC5

131

P40937
NALRRVIEKFTENTR

RFC5

136

P40937
QVTFGRTINKQIRDT

SNX25

711

Q9H3E2
KEFIIRRTATNRVLN

RASGRF2

906

O14827
ILEQRTSSNVINKRE

SEL1L2

51

Q5TEA6
QRIFDLQNKVLSSTE

TAF1L

1086

Q8IZX4
ASIENLRRVTDKVLN

IQGAP2

1046

Q13576
LQRTAISTNIKERLD

OPLAH

756

O14841
QLAAVNRESKFRVVI

PML

626

P29590
RNLVLKESQRASQVT

SMG1

3286

Q96Q15
KQVSARDLFRAQLIS

EPPK1

1526

P58107
TKQSLALIEQRIAER

SCN9A

16

Q15858
QRTENIKERSLQSLA

ST6GALNAC1

46

Q9NSC7
IIRAFRTATQLAVNK

CCT7

121

Q99832
RNVTSILELRNKEFK

TENM2

1266

Q9NT68
ERLSRETALQQKQVS

STAT5B

196

P51692
RDEKLAQLITRTQAI

MYH4

781

Q9Y623
DQILRVNDKSLARVT

WHRN

186

Q9P202
NSKVREQVRLELSFV

RHPN2

66

Q8IUC4
ERLSRETALQQKQVS

STAT5A

196

P42229
RFKQRLKVIQSLEDT

TBC1D9B

786

Q66K14
LQVERENVQKRTFTR

CLMN

26

Q96JQ2
QNSKFQRDLVTLRTD

CLEC10A

61

Q8IUN9
VRALSDLQFVKISRQ

CNNM2

796

Q9H8M5
VSVSNLNLVDKVRRF

TRAK1

836

Q9UPV9
LRQQVKETSFLRNTI

THBS4

241

P35443
ANKSIVNQVFLRERS

RNFT1

186

Q5M7Z0
LEITNSKREATNVRN

TRPM6

1301

Q9BX84
KSIANLIERRQFETK

POLR3C

441

Q9BUI4
QRRKRTSFSAEQLQL

MIXL1

86

Q9H2W2
LFRSQKVANERLLRS

RLF

1476

Q13129
IRFVSIDNKKRNIES

RNLS

221

Q5VYX0
NIAIQSQFTRTKEEL

TPR

106

P12270
KDLVQESLRRQVSAI

UROC1

376

Q96N76
VSETLQFKAQDLLRA

SUGP2

31

Q8IX01
AVIIQRLQKTASFRE

UBXN2A

241

P68543
RKQSLFARLENIIVT

VPS13C

1121

Q709C8
AKGTFRERLIQSLQE

TCEAL9

41

Q9UHQ7
QIRQLSERVKAAQTE

VPS53

196

Q5VIR6
LETQLFRFRLQASKI

PLEKHH1

21

Q9ULM0
SLRERLKIAQETAFN

TSGA10

121

Q9BZW7
RDIDNIFVKSLQSVQ

TTLL9

296

Q3SXZ7
KFRDLTVEELRNVNV

UEVLD

16

Q8IX04
RLQTQVELQARFSTE

SWAP70

376

Q9UH65
KREAQLRASLEVTQQ

TRIM65

136

Q6PJ69
KLVNNRTRIVNESDV

TRIM50

156

Q86XT4
RTSLLQLTQKQETFR

WDR87

986

Q6ZQQ6
SLRLFQTEEKIERTQ

ZGPAT

456

Q8N5A5
TSFALERNLRTQQEI

ZHX1-C8orf76

251

Q96EF9
ILVADEQNRALKRFS

TRIM56

521

Q9BRZ2
EVKALIRALFQNTER

ZW10

756

O43264
NLRSSVINSIREIKE

L1TD1

616

Q5T7N2
LLEKSRVVFQSENER

MYO5C

241

Q9NQX4