Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	group II metabotropic glutamate receptor activity	GRM2 GRM3	5.38e-05	2	147	2	GO:0001641
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	5.38e-05	2	147	2	GO:0003989
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A27 CACNA2D1 SPNS1 SCN11A SPNS2 TMC6 KCNK7 AQP5 SLC22A17 NDUFS3 SLC52A3 KCND1 SLC22A13 SLC49A4 CTNS STRA6 SLC33A1 SLC39A7 MFSD3 SLC27A5 SLC22A31	1.52e-04	1180	147	21	GO:0022857
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	1.61e-04	3	147	2	GO:0018858
GeneOntologyMolecularFunction	nitrate reductase activity	MTARC2 MTARC1	1.61e-04	3	147	2	GO:0008940
GeneOntologyMolecularFunction	transporter activity	SLC25A27 CACNA2D1 SPNS1 SCN11A SPNS2 TMC6 KCNK7 AQP5 SLC22A17 NDUFS3 SLC52A3 KCND1 SLC22A13 SLC49A4 TIMM29 CTNS STRA6 SLC33A1 SLC39A7 MFSD3 SLC27A5 SLC22A31	1.89e-04	1289	147	22	GO:0005215
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	3.20e-04	4	147	2	GO:0102391
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	7.92e-04	6	147	2	GO:0016421
GeneOntologyMolecularFunction	molybdenum ion binding	MTARC2 MTARC1	7.92e-04	6	147	2	GO:0030151
GeneOntologyMolecularFunction	molybdopterin cofactor binding	MTARC2 MTARC1	7.92e-04	6	147	2	GO:0043546
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	7.92e-04	6	147	2	GO:0009374
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A SLC27A5 ACSM2B	8.98e-04	26	147	3	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A SLC27A5 ACSM2B	1.00e-03	27	147	3	GO:0016405
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	1.10e-03	7	147	2	GO:0016885
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	1.46e-03	8	147	2	GO:0004321
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A SLC27A5 ACSM2B	1.51e-03	31	147	3	GO:0016878
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	CXCR3 AVPR2 GRM2 GRM3 LGR5 CHRM1 ADCY9 FFAR4 ADRA1D ADRB1 GPR157	7.16e-06	286	148	11	GO:0007188
GeneOntologyBiologicalProcess	regulation of body fluid levels	CFH AVPR2 EMILIN2 DGKD CHRM1 F5 AQP5 TMX1 ADRB1 HPS6 CTNS HYAL2 GP9	1.87e-05	442	148	13	GO:0050878
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	5.11e-05	2	148	2	GO:2001295
Domain	MFS_dom	SPNS1 SPNS2 SLC22A17 SLC22A13 SLC49A4 SLC33A1 MFSD3 SLC22A31	1.10e-05	134	147	8	IPR020846
Domain	MFS	SPNS1 SPNS2 SLC22A17 SLC22A13 SLC49A4 MFSD3 SLC22A31	2.33e-05	108	147	7	PS50850
Domain	ACC_central	ACACA ACACB	6.15e-05	2	147	2	PF08326
Domain	CCDC74	CCDC74B CCDC74A	6.15e-05	2	147	2	IPR033226
Domain	CCDC74_C	CCDC74B CCDC74A	6.15e-05	2	147	2	IPR029422
Domain	CCDC74_C	CCDC74B CCDC74A	6.15e-05	2	147	2	PF14917
Domain	AcCoA_COase_cen	ACACA ACACB	6.15e-05	2	147	2	IPR013537
Domain	MOSC	MTARC2 MTARC1	1.84e-04	3	147	2	PF03473
Domain	MOSC_N	MTARC2 MTARC1	1.84e-04	3	147	2	PF03476
Domain	MOSC	MTARC2 MTARC1	1.84e-04	3	147	2	PS51340
Domain	MOSC_N	MTARC2 MTARC1	1.84e-04	3	147	2	IPR005303
Domain	MoCF_Sase_C	MTARC2 MTARC1	1.84e-04	3	147	2	IPR005302
Domain	AMP-bd_C	ACSM2A SLC27A5 ACSM2B	3.00e-04	17	147	3	IPR025110
Domain	AMP-binding_C	ACSM2A SLC27A5 ACSM2B	3.00e-04	17	147	3	PF13193
Domain	MFS_1	SPNS1 SPNS2 SLC22A17 SLC22A13 MFSD3	3.53e-04	77	147	5	PF07690
Domain	MFS	SPNS1 SPNS2 SLC22A17 SLC22A13 MFSD3	3.53e-04	77	147	5	IPR011701
Domain	Carboxyl_trans	ACACA ACACB	3.65e-04	4	147	2	PF01039
Domain	COA_CT_CTER	ACACA ACACB	3.65e-04	4	147	2	PS50989
Domain	COA_CT_NTER	ACACA ACACB	3.65e-04	4	147	2	PS50980
Domain	COA_CT_N	ACACA ACACB	3.65e-04	4	147	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	3.65e-04	4	147	2	IPR011763
Domain	Carboxyl_trans	ACACA ACACB	3.65e-04	4	147	2	IPR000022
Domain	Biotin_BS	ACACA ACACB	6.06e-04	5	147	2	IPR001882
Domain	Biotin_COase_C	ACACA ACACB	6.06e-04	5	147	2	IPR005482
Domain	HnRNP_R/Q_splicing_fac	A1CF RBM47	6.06e-04	5	147	2	IPR006535
Domain	BC	ACACA ACACB	6.06e-04	5	147	2	PS50979
Domain	Pyrv_Knase-like_insert_dom	MTARC2 MTARC1	6.06e-04	5	147	2	IPR011037
Domain	Biotin_carb_C	ACACA ACACB	6.06e-04	5	147	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	6.06e-04	5	147	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	6.06e-04	5	147	2	IPR011764
Domain	CPSASE_1	ACACA ACACB	6.06e-04	5	147	2	PS00866
Domain	BIOTIN	ACACA ACACB	6.06e-04	5	147	2	PS00188
Domain	Rudment_hybrid_motif	ACACA ACACB	9.04e-04	6	147	2	IPR011054
Domain	CPSASE_2	ACACA ACACB	9.04e-04	6	147	2	PS00867
Domain	AMP-binding_CS	ACSM2A SLC27A5 ACSM2B	1.09e-03	26	147	3	IPR020845
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	1.26e-03	7	147	2	IPR005479
Domain	BC-like_N	ACACA ACACB	1.26e-03	7	147	2	IPR005481
Domain	CPSase_L_D2	ACACA ACACB	1.26e-03	7	147	2	PF02786
Domain	Biotin_carb_N	ACACA ACACB	1.26e-03	7	147	2	PF00289
Domain	AMP_BINDING	ACSM2A SLC27A5 ACSM2B	1.35e-03	28	147	3	PS00455
Domain	AMP-binding	ACSM2A SLC27A5 ACSM2B	1.66e-03	30	147	3	PF00501
Domain	AMP-dep_Synth/Lig	ACSM2A SLC27A5 ACSM2B	1.66e-03	30	147	3	IPR000873
Domain	GPCR_3_mtglu_rcpt	GRM2 GRM3	1.67e-03	8	147	2	IPR000162
Domain	Biotin_lipoyl	ACACA ACACB	2.14e-03	9	147	2	PF00364
Domain	GPCR_Rhodpsn_7TM	CXCR3 AVPR2 MCHR2 GPR152 GPR135 LGR5 CHRM1 FFAR4 GPR146 ADRA1D ADRB1 GPR157 OR2H2	2.47e-03	670	147	13	IPR017452
Domain	BIOTINYL_LIPOYL	ACACA ACACB	2.66e-03	10	147	2	PS50968
Domain	Biotin_lipoyl	ACACA ACACB	2.66e-03	10	147	2	IPR000089
Domain	ADR_fam	ADRA1D ADRB1	2.66e-03	10	147	2	IPR002233
Domain	MFS_sugar_transport-like	SLC22A17 SLC22A13 SLC22A31	2.82e-03	36	147	3	IPR005828
Domain	Sugar_tr	SLC22A17 SLC22A13 SLC22A31	2.82e-03	36	147	3	PF00083
Domain	EGF_dom	THBS2 MEGF8	3.86e-03	12	147	2	IPR024731
Domain	Single_hybrid_motif	ACACA ACACB	3.86e-03	12	147	2	IPR011053
Domain	EGF_3	THBS2 MEGF8	3.86e-03	12	147	2	PF12947
Domain	-	ACACA ACACB	4.53e-03	13	147	2	3.40.50.20
Domain	NCD3G	GRM2 GRM3	4.53e-03	13	147	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM2 GRM3	4.53e-03	13	147	2	IPR011500
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH5	5.26e-03	14	147	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH5	5.26e-03	14	147	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH5	5.26e-03	14	147	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH5	5.26e-03	14	147	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH5	5.26e-03	14	147	2	IPR011704
Domain	ATP_GRASP	ACACA ACACB	5.26e-03	14	147	2	PS50975
Domain	ATP-grasp	ACACA ACACB	5.26e-03	14	147	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	5.26e-03	14	147	2	IPR016185
Domain	MT	DNAH3 DNAH5	5.26e-03	14	147	2	PF12777
Domain	AAA_8	DNAH3 DNAH5	5.26e-03	14	147	2	PF12780
Domain	GPCR_3_CS	GRM2 GRM3	5.26e-03	14	147	2	IPR017979
Domain	AAA_5	DNAH3 DNAH5	5.26e-03	14	147	2	PF07728
Domain	DHC_fam	DNAH3 DNAH5	6.04e-03	15	147	2	IPR026983
Domain	Dynein_heavy	DNAH3 DNAH5	6.04e-03	15	147	2	PF03028
Domain	Dynein_heavy_dom	DNAH3 DNAH5	6.04e-03	15	147	2	IPR004273
Domain	-	ACACA ACACB	6.04e-03	15	147	2	3.30.1490.20
Domain	7tm_1	CXCR3 AVPR2 MCHR2 GPR152 GPR135 LGR5 CHRM1 FFAR4 GPR146 ADRA1D ADRB1 OR2H2	7.31e-03	677	147	12	PF00001
Pubmed	Regulation of M₃ muscarinic receptor expression and function by transmembrane protein 147.	AVPR2 CHRM1 TMEM147	3.14e-07	4	150	3	21056967
Pubmed	Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.	GRM2 GRM3	1.85e-05	2	150	2	23616537
Pubmed	Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.	GRM2 GRM3	1.85e-05	2	150	2	30939596
Pubmed	The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.	GRM2 GRM3	1.85e-05	2	150	2	17670976
Pubmed	The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.	GRM2 GRM3	1.85e-05	2	150	2	32525061
Pubmed	The Chlamydomonas reinhardtii molybdenum cofactor enzyme crARC has a Zn-dependent activity and protein partners similar to those of its human homologue.	MTARC2 MTARC1	1.85e-05	2	150	2	21803866
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	1.85e-05	2	150	2	24944901
Pubmed	Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.	GRM2 GRM3	1.85e-05	2	150	2	8838577
Pubmed	Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.	GRM2 GRM3	1.85e-05	2	150	2	34330748
Pubmed	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.	GRM2 GRM3	1.85e-05	2	150	2	25434487
Pubmed	NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.	GRM2 GRM3	1.85e-05	2	150	2	28285415
Pubmed	mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.	GRM2 GRM3	1.85e-05	2	150	2	34090896
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	1.85e-05	2	150	2	20139635
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	1.85e-05	2	150	2	28081256
Pubmed	MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases.	MTARC2 MTARC1	1.85e-05	2	150	2	11886751
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	1.85e-05	2	150	2	26976583
Pubmed	Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.	GRM2 GRM3	1.85e-05	2	150	2	22089319
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	1.85e-05	2	150	2	19634011
Pubmed	Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians.	MTARC2 MTARC1	1.85e-05	2	150	2	24423752
Pubmed	Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.	GRM2 GRM3	1.85e-05	2	150	2	21881873
Pubmed	Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.	GRM2 GRM3	1.85e-05	2	150	2	21832989
Pubmed	The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.	GRM2 GRM3	1.85e-05	2	150	2	25158312
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	1.85e-05	2	150	2	25001074
Pubmed	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.	GRM2 GRM3	1.85e-05	2	150	2	18720515
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	1.85e-05	2	150	2	10677481
Pubmed	The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane.	MTARC2 MTARC1	1.85e-05	2	150	2	23086957
Pubmed	Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.	LGR5 SLC39A7	1.85e-05	2	150	2	27736879
Pubmed	Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.	GRM2 GRM3	1.85e-05	2	150	2	15246118
Pubmed	Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.	GRM2 GRM3	1.85e-05	2	150	2	18853337
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	1.85e-05	2	150	2	24338821
Pubmed	CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.	CCDC74B CCDC74A	1.85e-05	2	150	2	31521166
Pubmed	Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.	GRM2 GRM3	1.85e-05	2	150	2	21360593
Pubmed	Developmental expression of mGlu2 and mGlu3 in the mouse brain.	GRM2 GRM3	1.85e-05	2	150	2	27818290
Pubmed	Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.	GRM2 GRM3	1.85e-05	2	150	2	19638469
Pubmed	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.	GRM2 GRM3	1.85e-05	2	150	2	21628565
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	1.85e-05	2	150	2	16521160
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	1.85e-05	2	150	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	1.85e-05	2	150	2	27693630
Pubmed	Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.	GRM2 GRM3	1.85e-05	2	150	2	24053122
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	1.85e-05	2	150	2	32215608
Pubmed	Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.	GRM2 GRM3	1.85e-05	2	150	2	38969501
Pubmed	The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine.	MTARC2 MTARC1	1.85e-05	2	150	2	25713076
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	1.85e-05	2	150	2	29772612
Pubmed	Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.	GRM2 GRM3	1.85e-05	2	150	2	25583490
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	1.85e-05	2	150	2	29976587
Pubmed	Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion.	A1CF ACACB	1.85e-05	2	150	2	27693463
Pubmed	The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.	GRM2 GRM3	1.85e-05	2	150	2	23624743
Pubmed	Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.	GRM2 GRM3	1.85e-05	2	150	2	25950516
Pubmed	Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.	GRM2 GRM3	1.85e-05	2	150	2	19386277
Pubmed	The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.	GRM2 GRM3	1.85e-05	2	150	2	7965099
Pubmed	Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.	GRM2 GRM3	1.85e-05	2	150	2	24080311
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	1.85e-05	2	150	2	15749055
Pubmed	Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.	ADRA1D ADRB1	1.85e-05	2	150	2	26203906
Pubmed	Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).	MTARC2 MTARC1	1.85e-05	2	150	2	21029045
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	1.85e-05	2	150	2	29433631
Pubmed	Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse.	MTARC2 MTARC1	1.85e-05	2	150	2	38437227
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	1.85e-05	2	150	2	29948332
Pubmed	Enhancing fatty acid oxidation negatively regulates PPARs signaling in the heart.	A1CF ACACB	1.85e-05	2	150	2	32592696
Pubmed	Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.	GRM2 GRM3	1.85e-05	2	150	2	27911756
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	1.85e-05	2	150	2	36076520
Pubmed	Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.	GRM2 GRM3	1.85e-05	2	150	2	23392308
Pubmed	Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.	GRM2 GRM3	1.85e-05	2	150	2	20970439
Pubmed	SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.	A1CF SPEG	1.85e-05	2	150	2	27729468
Pubmed	Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.	GRM2 GRM3	1.85e-05	2	150	2	34217776
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	1.85e-05	2	150	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	1.85e-05	2	150	2	30244972
Pubmed	Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.	GRM2 GRM3	1.85e-05	2	150	2	21057775
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR152 GPR135 GRM2 FFAR4 GPR146	2.43e-05	79	150	5	12679517
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	SLC25A27 PTGES2 ACACA ACACB MTRES1 NLRX1 MRPL51 NDUFS3 CRY1 MECR TIMM50 MTARC2 AKAP1 ACSM2A ACSM2B	5.06e-05	1047	150	15	18614015
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	SLC25A27 PTGES2 ACACA ACACB MTRES1 NLRX1 MRPL51 NDUFS3 CRY1 MECR MTARC2 AKAP1 ACSM2A MTARC1	5.15e-05	926	150	14	20877624
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	5.53e-05	3	150	2	34668531
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	5.53e-05	3	150	2	30018077
Pubmed	Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.	A1CF RBM47	5.53e-05	3	150	2	30309881
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM2 GRM3	5.53e-05	3	150	2	34620856
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	5.53e-05	3	150	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	5.53e-05	3	150	2	18031993
Pubmed	Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy.	A1CF ACACB	5.53e-05	3	150	2	32597196
Pubmed	G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.	A1CF ADRB1	5.53e-05	3	150	2	18635825
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	5.53e-05	3	150	2	20457939
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	5.53e-05	3	150	2	36417534
Pubmed	Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.	GRM2 GRM3	5.53e-05	3	150	2	38864289
Pubmed	Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.	GRM2 GRM3	5.53e-05	3	150	2	25150943
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	5.53e-05	3	150	2	18455495
Pubmed	Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse.	ADRA1D ADRB1	5.53e-05	3	150	2	18079196
Pubmed	Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.	METTL23 JMJD6	5.53e-05	3	150	2	18564434
Pubmed	The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission.	DAGLB ICAM5	5.53e-05	3	150	2	20159446
Pubmed	Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.	GRM2 GRM3	5.53e-05	3	150	2	21173788
Pubmed	Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.	CACNA2D1 THBS2	5.53e-05	3	150	2	19818485
Pubmed	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.	GRM2 GRM3	5.53e-05	3	150	2	24949866
Pubmed	Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.	ADRA1D ADRB1	5.53e-05	3	150	2	15598970
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	5.53e-05	3	150	2	28877461
Pubmed	Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex.	SEH1L SEC13	5.53e-05	3	150	2	14517296
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	5.53e-05	3	150	2	17521700
Pubmed	Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.	A1CF RBM47	5.53e-05	3	150	2	30844405
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	5.53e-05	3	150	2	31990961
Pubmed	FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1.	NLRX1 FAF1	5.53e-05	3	150	2	28542569
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	5.53e-05	3	150	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	5.53e-05	3	150	2	17210641
Pubmed	mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.	GRM2 GRM3	5.53e-05	3	150	2	31735403
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	5.53e-05	3	150	2	28768177
Cytoband	16p12.3	DNAH3 ACSM2A ACSM2B	1.94e-04	34	151	3	16p12.3
GeneFamily	Solute carriers	SLC25A27 SLC22A17 SLC52A3 SLC22A13 SLC49A4 SLC33A1 SLC39A7 SLC27A5 SLC22A31	2.94e-04	395	98	9	752
GeneFamily	Acyl-CoA synthetase family	ACSM2A SLC27A5 ACSM2B	3.67e-04	26	98	3	40
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM2 GRM3	7.97e-04	8	98	2	281
GeneFamily	G protein-coupled receptors, Class A orphans	GPR152 GPR135 LGR5 GPR146	8.52e-04	78	98	4	262
GeneFamily	Adrenoceptors	ADRA1D ADRB1	1.02e-03	9	98	2	169
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT3 FUT8	2.18e-03	13	98	2	434
GeneFamily	Dyneins, axonemal	DNAH3 DNAH5	3.75e-03	17	98	2	536
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_TAK1_KO_BCELL_6H_DN	INHBC NT5E PAPLN AQP5 PGK2 FANCC DNAAF8 SYT8 SLC22A13	2.15e-06	200	148	9	M9933
Coexpression	GSE41978_WT_VS_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN	ICAM5 TIMM50 MTARC2 TIMM29 CTNS STRA6 MFSD3 GP9	1.89e-05	200	148	8	M9554
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_COLORECTAL_TUMOR	PAPLN THBS2 MEGF8 CLEC11A CSPG4	2.10e-05	59	148	5	M47989
Coexpression	LEIN_CHOROID_PLEXUS_MARKERS	CFH ACACB F5 CLDN1 STRA6 RBM47	2.98e-05	105	148	6	M1719
Coexpression	LEIN_CHOROID_PLEXUS_MARKERS	CFH ACACB F5 CLDN1 STRA6 RBM47	3.67e-05	109	148	6	MM1214
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ACACA NT5E CECR2 AQP5 CAPN8 FUT8 SLC22A31	1.81e-06	170	150	7	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NT5E AQP5 ARHGAP22 MISP IL17RE HPS6 RBM47	2.20e-06	175	150	7	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NT5E AQP5 ARHGAP22 MISP IL17RE HPS6 RBM47	2.20e-06	175	150	7	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	ACACA CECR2 AQP5 CAPN8 FUT8 DNAH5 SLC22A31	3.18e-06	185	150	7	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	VE-CD4-CD8_2\|VE / Condition, Cell_class and T cell subcluster	SCN11A NT5E SPNS2 SPEG KLHDC9 CAPN8	3.65e-06	122	150	6	6745035feaf807b6a6b9537ac9d5ee0e000196eb
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	TMC6 FAM83E CAPN8 ARHGAP22 RBM47 DNAH5 SLC22A31	3.66e-06	189	150	7	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	ASK440-Epithelial-Secretory\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CFH AQP5 CLDN1 CAPN8 MISP SYT8 DNAH5	4.20e-06	193	150	7	50e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PRSS41 AQP5 CSPG4 DLL3 DNAH5	1.14e-05	87	150	5	8ca87e4a332ef6f035b13e80dcc0110f32172c9a
ToppCell	Substantia_nigra-Macroglia-POLYDENDROCYTE-P3\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PRSS41 AQP5 CSPG4 DLL3 DNAH5	1.14e-05	87	150	5	4ec3a9489981ed69061c1ca363271edf6a3635d2
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SCN11A CXCR3 MCHR2 TP53TG5 CGRRF1 PLD2	1.24e-05	151	150	6	d19fc363ba1d7ff77e0adcaacafa4c64e1143f40
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 FAM78B KCNK7 ADRB1 KCND1 ICAM5	1.44e-05	155	150	6	c58a5fb8d853f12204e961d633e83452eb12a659
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 FAM78B KCNK7 ADRB1 KCND1 ICAM5	1.44e-05	155	150	6	9cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C5orf22 FAM78B ADCY9 HPS6 PLD2 UTY	1.98e-05	164	150	6	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAGLB CFH PPFIBP2 GDF6 ARHGAP22 CLEC11A	2.20e-05	167	150	6	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ACACA NEB PRSS36 SLC52A3 IL17RE ANTKMT	2.20e-05	167	150	6	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5E AQP5 ADCY9 SLC52A3 ARHGAP22 IL17RE	2.20e-05	167	150	6	bebc2493a2ee41920b21c2b774a1c5a9619315c4
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DAGLB CFH PPFIBP2 GDF6 ARHGAP22 CLEC11A	2.20e-05	167	150	6	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	facs-Lung-3m-Epithelial-alveolar_epithelial-type_I_pneumocyte-type_1_alveolar_epithelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NT5E AQP5 ADCY9 SLC52A3 ARHGAP22 IL17RE	2.20e-05	167	150	6	9f2661729a2d58e17a9203a563d538c08a3dbbbc
ToppCell	Club_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CFH AQP5 CLDN1 CAPN8 MISP SYT8	2.95e-05	176	150	6	88c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCell	(06)_Krt4/13+\|World / shred by cell type and Timepoint	SPNS2 F5 AQP5 FFAR4 SYT8 SOWAHB	3.15e-05	178	150	6	46efdf03aa1317bc600138e871509b995e773cce
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH PPFIBP2 FAM78B PAPLN ARHGAP22 IL17RE	3.45e-05	181	150	6	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH PPFIBP2 FAM78B PAPLN ARHGAP22 IL17RE	3.45e-05	181	150	6	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	ACACA AQP5 CAPN8 FUT8 DNAH5 SLC22A31	4.14e-05	187	150	6	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	Mesenchymal_cells-Ng2+_MSCs\|Mesenchymal_cells / Lineage and Cell class	CFH PPFIBP2 SPNS2 FAM78B FANCC CLEC11A	4.14e-05	187	150	6	e899b906409f3fad69cb3d3c6432c3fd862ae3c1
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ANKRD65 AQP5 CLDN1 CAPN8 MISP SYT8	4.27e-05	188	150	6	61422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ANKRD65 AQP5 CLDN1 CAPN8 MISP SYT8	4.27e-05	188	150	6	18698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CCDC74B KLHDC9 DNAAF8 SYT8 CCDC74A DNAH5	4.66e-05	191	150	6	8a5a2188b13ef4bbfd626a42565566708a751c1b
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CCDC74B KLHDC9 DNAAF8 SYT8 CCDC74A DNAH5	4.66e-05	191	150	6	e314dd8f1a841cab847ae3703bedfe1bc623ac61
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	ACACA CECR2 CAPN8 DNAH5 UTY SLC22A31	4.80e-05	192	150	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	COVID-19-lung-Secretory\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFH AQP5 CLDN1 CAPN8 SYT8 DNAH5	4.80e-05	192	150	6	59261098ccb52306f837f632ebaea45b90ad30fe
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QPCTL DLL3 FUT8 RBM47 SLC33A1 SLC39A7	4.80e-05	192	150	6	6417468829517a0f6e04e7e44eec1622001d4c5c
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIBP2 SLC52A3 SYT8 IL17RE RNF128 RBM47	5.08e-05	194	150	6	1531dcace28a14bd700e909a027426a8cee20337
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPNS2 AQP5 CLDN1 FFAR4 CAPN8 RBM47	5.23e-05	195	150	6	c87edbb8c92a0541b6de2632ac2f9cef44c7e304
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAM83E AQP5 CAPN8 MISP STRA6 FUT3	5.38e-05	196	150	6	c18874f37b90e6afacc562b2082b67ea8a7cb4a4
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPNS2 AQP5 CAPN8 MISP STRA6 FUT3	5.38e-05	196	150	6	a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CPA4 SPNS2 AQP5 CAPN8 MISP FUT3	5.38e-05	196	150	6	3e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CPA4 SPNS2 AQP5 CAPN8 MISP FUT3	5.38e-05	196	150	6	1efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPNS2 AQP5 CAPN8 MISP STRA6 FUT3	5.38e-05	196	150	6	91a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPNS2 AQP5 CAPN8 MISP STRA6 FUT3	5.38e-05	196	150	6	e819088a74d29e958371aa851ac9c74ec55367b7
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPNS2 AQP5 CAPN8 MISP STRA6 FUT3	5.38e-05	196	150	6	e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH AQP5 CLDN1 MISP AKAP1 HYAL2	5.53e-05	197	150	6	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH AQP5 CLDN1 MISP AKAP1 HYAL2	5.53e-05	197	150	6	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SPNS2 AQP5 CAPN8 MISP FUT3 DNAH5	5.53e-05	197	150	6	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CPA4 SPNS2 AQP5 CAPN8 MISP FUT3	5.53e-05	197	150	6	08b371309cd790b171ed76cabc7d910e71cd2835
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH FAM83E AQP5 MISP FUT3 HYAL2	5.53e-05	197	150	6	a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CPA4 SPNS2 AQP5 CAPN8 MISP FUT3	5.53e-05	197	150	6	9f49feee38647bbf964974aac96fa75602186b5c
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA CECR2 DGKD CAPN8 RBM47 SLC22A31	5.69e-05	198	150	6	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	distal-Epithelial-Ciliated-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CCDC74B KLHDC9 DNAAF8 SYT8 CCDC74A DNAH5	5.69e-05	198	150	6	d30d6c6a0a78b7571318b5b2a0186df96dd0f5a9
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FAM83E AQP5 CAPN8 MISP STRA6 FUT3	5.85e-05	199	150	6	ec1e110671e7725f752163c7241dbbf638dec2b2
ToppCell	distal-1-Epithelial-Ciliated\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CCDC74B KLHDC9 DNAAF8 SYT8 CCDC74A DNAH5	5.85e-05	199	150	6	4120e4a2bc05adebe1e1e9670ed7ea55142eb83d
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANKRD65 AQP5 CLDN1 MISP SYT8 FUT3	6.02e-05	200	150	6	5f0f67958c9635db53e61f8370a92da6ea3e80fe
ToppCell	Bronchial-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANKRD65 AQP5 CLDN1 CAPN8 MISP DNAH5	6.02e-05	200	150	6	d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CPA4 CFH CLDN1 THBS2 LRRN2 HAND2	6.02e-05	200	150	6	c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCell	proximal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH AQP5 CLDN1 FAF1 ARHGAP22 SYT8	6.02e-05	200	150	6	8083047c213488e40b975013e3c5c43f7c0c15b2
ToppCell	proximal-Epithelial-Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH AQP5 CLDN1 FAF1 ARHGAP22 SYT8	6.02e-05	200	150	6	c6a491d3e2dae6618f25dc3c9aac08f657348168
ToppCell	proximal-Epithelial-Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH AQP5 CLDN1 FAF1 ARHGAP22 SYT8	6.02e-05	200	150	6	f5d48f521abbd1e07de05f2b3768ad2f9675f1e1
ToppCell	Lymphoid-T_cells_(Cd8+_T_cell)\|World / shred on cell class and cell subclass (v4)	CXCR3 CES5A PRSS41 DLL3 RINL	1.08e-04	139	150	5	c85f50fb536f4df6fa4dbdebe48e1ecea1df1121
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DAGLB FUZ MECR STRA6 OR2H2	1.28e-04	144	150	5	b638398f559e7fd9d4294d1c830beeb20f905960
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG GPR146 CGRRF1 DCHS1 LRRN2	1.75e-04	154	150	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	F5 CCDC74A STRA6 FUT8 MTARC1	1.80e-04	155	150	5	d10cf5e922dbd3ca46660404da5aca43f181fc19
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CPA4 CFH CXCR3 PPFIBP2 PRSS36	1.80e-04	155	150	5	93f21b09f6f7755991d67886361b1c42a50fbbfc
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INHBC F5 CLDN1 MTARC1 SLC27A5	1.86e-04	156	150	5	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	A1CF AQP5 GPR146 ARHGAP22 IL17RE	2.21e-04	162	150	5	34b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	CFH CACNA2D1 AQP5 IL17RE CLEC11A	2.21e-04	162	150	5	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	CFH CACNA2D1 AQP5 IL17RE CLEC11A	2.21e-04	162	150	5	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FAM83E AQP5 MISP HPS6 SPSB2	2.21e-04	162	150	5	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CAPN8 IL17RE FUT8 AKAP1 DNAH5	2.21e-04	162	150	5	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	AQP5 CAPN8 FUT8 DNAH5 SLC22A31	2.27e-04	163	150	5	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	Basal_cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CACNA2D1 LGR5 AQP5 CLDN1 STRA6	2.27e-04	163	150	5	679e25e5548d157d49a73057a3b5617dccda260f
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACB AVPR2 PLD2 MFSD3 SPSB2	2.27e-04	163	150	5	b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACB AVPR2 PLD2 MFSD3 SPSB2	2.27e-04	163	150	5	c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QPCTL LEMD3 EMILIN2 PAPLN MTARC2	2.34e-04	164	150	5	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 KCNK7 IL17RE LRRN2 RINL	2.34e-04	164	150	5	467ad12884b70d243988174ae960ee2b7b6cfb0c
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 KCNK7 IL17RE LRRN2 RINL	2.34e-04	164	150	5	4e1861382c9e93856da19303474c8975c19706d2
ToppCell	Club-club-16\|World / Class top	F5 AQP5 CLDN1 FFAR4 RINL	2.41e-04	165	150	5	684f3c4872bd630d3f744f15d57dccfd34e96160
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	CXCR3 QPCTL GPR146 CTNS AKAP1	2.41e-04	165	150	5	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	TCGA-Lung-Solid_Tissue_Normal\|TCGA-Lung / Sample_Type by Project: Shred V9	CHRM1 GPR146 SYT15B ADRB1 GP9	2.47e-04	166	150	5	a8ebdd3cb7f59b3feeaacda45ce6d40d10db556f
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung\|TCGA-Lung / Sample_Type by Project: Shred V9	CHRM1 GPR146 SYT15B ADRB1 GP9	2.47e-04	166	150	5	c64971c27cb445dffc5a636d4b6a60261b93a2db
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue\|TCGA-Lung / Sample_Type by Project: Shred V9	CHRM1 GPR146 SYT15B ADRB1 GP9	2.47e-04	166	150	5	2f3072a7af048f184d33065fdd36153fd563155a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CECR2 AQP5 FUT8 DNAH5 SLC22A31	2.47e-04	166	150	5	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	TCGA-Lung-Solid_Tissue_Normal-Lung-Lung_normal_tissue-6\|TCGA-Lung / Sample_Type by Project: Shred V9	CHRM1 GPR146 SYT15B ADRB1 GP9	2.47e-04	166	150	5	188f2575511f418216874aed9118aa6f165252cb
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	NT5E GPR146 LRRN2 ACSM2A ACSM2B	2.47e-04	166	150	5	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFH SPNS2 AQP5 CAPN8 STRA6	2.54e-04	167	150	5	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CXCR3 KCNK7 IL17RE LRRN2 RINL	2.54e-04	167	150	5	5d1919bea8e5a52ac6fc953caff15509b7142923
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CXCR3 KCNK7 IL17RE LRRN2 RINL	2.54e-04	167	150	5	d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD65 SPNS2 AQP5 CLDN1 DNAH5	2.69e-04	169	150	5	8c96e1baa38ec5e777e627ab9dbce025e771f2c0
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR152 FFAR4 SEMA4C ARHGAP22 PLD2	2.69e-04	169	150	5	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR152 FFAR4 SEMA4C ARHGAP22 PLD2	2.69e-04	169	150	5	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD65 SPNS2 AQP5 CLDN1 DNAH5	2.69e-04	169	150	5	86041be5d3aeab5b9269f7912791b944f325a1b4
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPFIBP2 PAPLN DGKD ADRA1D CSPG4	2.76e-04	170	150	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SCN11A FAM83E FUT3 RNF128 SLC22A31	2.91e-04	172	150	5	a9e65201ad9ab4f64251aba2c0bb3d8f9e0193b6
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SCN11A FAM83E FUT3 RNF128 SLC22A31	2.91e-04	172	150	5	26006967d0c82f7bd9b36a18e97a1b93e856aa67
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FFAR4 ARHGAP22 GPR157 ICAM5 STRA6	2.91e-04	172	150	5	48d0cfc37d1b1ae48ed8f8b2711abeb609d2bb6e
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CACNA2D1 CCDC74B CAPN8 ICAM5 FUT3	3.07e-04	174	150	5	e2243f1e48e3275753a2b3a69d06eefce69a8ded
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 KCNK7 CRY1 IL17RE LRRN2	3.07e-04	174	150	5	aae7ab9df5a78716034ddfd5bd47adc69912d624
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPNS2 CECR2 F5 CLDN1 STRA6	3.07e-04	174	150	5	c58328c2f262506a4518f49f148e29874faf9171
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 KCNK7 CRY1 IL17RE LRRN2	3.07e-04	174	150	5	d9489c4196d103ead8cb6279492bbe563a222e45
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	CFH PPFIBP2 FAM78B CLEC11A MTARC1	3.07e-04	174	150	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	AQP5 CAPN8 MISP RNF128 SLC22A31	3.07e-04	174	150	5	edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 NT5E KCND1 RINL RNF128	3.07e-04	174	150	5	096bc6f1889f2bbadfe1e1a3eb6ae569aaa2ee7d
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB NMT1	1.08e-06	5	142	3	DOID:0080000 (implicated_via_orthology)
Disease	X-21319 measurement	ACSM2A ACSM2B	2.30e-05	2	142	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	6.88e-05	3	142	2	EFO_0021242
Disease	Addicted to cocaine	GRM2 GRM3	6.88e-05	3	142	2	C0858355
Disease	sphingolipidosis (implicated_via_orthology)	SPNS1 SPNS2	6.88e-05	3	142	2	DOID:1927 (implicated_via_orthology)
Disease	Heterotopia, Periventricular, Autosomal Recessive	ARFGEF2 DCHS1	6.88e-05	3	142	2	C1842563
Disease	glutaminyl-peptide cyclotransferase-like protein measurement	CFH QPCTL	6.88e-05	3	142	2	EFO_0801632
Disease	EH domain-binding protein 1 measurement	CFH F5	1.37e-04	4	142	2	EFO_0801561
Disease	uncharacterized protein KIAA0040 measurement	CFH F5	1.37e-04	4	142	2	EFO_0802196
Disease	guanylyl cyclase-activating protein 1 measurement	CFH F5	1.37e-04	4	142	2	EFO_0801663
Disease	E3 ubiquitin-protein ligase DTX1 measurement	CFH F5	1.37e-04	4	142	2	EFO_0802503
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	2.28e-04	5	142	2	EFO_0800378
Disease	thrombospondin-2 measurement	CFH THBS2	3.41e-04	6	142	2	EFO_0008299
Disease	collagen alpha-2(XI) chain measurement	CFH SLC39A7	3.41e-04	6	142	2	EFO_0801490
Disease	cytochrome c oxidase subunit 6C measurement	CFH F5	3.41e-04	6	142	2	EFO_0801515
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	3.41e-04	6	142	2	EFO_0800106
Disease	uronyl 2-sulfotransferase measurement	DAGLB CFH	4.75e-04	7	142	2	EFO_0803240
Disease	Sacral agenesis	GDF6 FUZ	4.75e-04	7	142	2	C0344490
Disease	E3 ubiquitin-protein ligase RNF13 measurement	CFH F5	6.32e-04	8	142	2	EFO_0801556
Disease	Microphthalmia associated with colobomatous cyst	GDF6 STRA6	6.32e-04	8	142	2	C2931501
Disease	X-17676 measurement	DNAH3 ACSM2B	6.32e-04	8	142	2	EFO_0800785
Disease	uric acid measurement	DNAH3 SPNS1 A1CF INHBC TMC6 F5 ADCY9 FAF1 SLC27A5 ACSM2B	7.68e-04	610	142	10	EFO_0004761
Disease	renovascular hypertension (implicated_via_orthology)	CXCR3 ADRB1	8.10e-04	9	142	2	DOID:1591 (implicated_via_orthology)
Disease	cholelithiasis	DAGLB TMEM147 FUT3 VPS13B	8.76e-04	88	142	4	EFO_0004799
Disease	calcium measurement	CPA4 CFH A1CF NLRX1 DGKD SEMA4C ADRB1 TMEM147 AKAP1 RBM47	9.57e-04	628	142	10	EFO_0004838
Disease	membranoproliferative glomerulonephritis (implicated_via_orthology)	CFH F5	1.01e-03	10	142	2	DOID:2920 (implicated_via_orthology)
Disease	waist-hip ratio, high density lipoprotein cholesterol measurement	DAGLB ADRB1	1.01e-03	10	142	2	EFO_0004343, EFO_0004612
Disease	T-cell surface glycoprotein CD3 epsilon chain measurement	CFH F5	1.73e-03	13	142	2	EFO_0802114
Disease	Congestive heart failure	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C0018802
Disease	Heart failure	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C0018801
Disease	Left-Sided Heart Failure	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C0023212
Disease	Heart Failure, Right-Sided	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C0235527
Disease	Heart Decompensation	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C1961112
Disease	Myocardial Failure	ACACA AVPR2 ADRB1 HAND2	2.00e-03	110	142	4	C1959583
Disease	neuronal ceroid lipofuscinosis (implicated_via_orthology)	SPNS1 SPNS2	2.01e-03	14	142	2	DOID:14503 (implicated_via_orthology)
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	PTGES2 A1CF ACACB GPR146 ADRB1 TMEM147	2.17e-03	274	142	6	EFO_0004530, EFO_0004612
Disease	infant head circumference	ARFGEF2 ADRB1	2.32e-03	15	142	2	EFO_0004577
Disease	glucose measurement	A1CF QPCTL PPFIBP2 KCNK7 ADCY9 MEGF8 NMT1	2.50e-03	380	142	7	EFO_0004468
Disease	partial epilepsy	ADCY9 SLC33A1	2.98e-03	17	142	2	EFO_0004263
Disease	brain infarction	THBS2 RBM47	3.35e-03	18	142	2	EFO_0004277
Disease	autoimmune thyroid disease, Hashimoto's thyroiditis, Graves disease	SLC25A27 PRSS36	3.35e-03	18	142	2	EFO_0003779, EFO_0004237, EFO_0006812
Disease	serum carcinoembryonic antigen measurement	FAM83E FUT3	4.13e-03	20	142	2	EFO_0005760

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALLVWWTPKVEHQGG	SLC33A1	391	O00400
VVPFGATIVVWGRWE	ADRB1	111	P08588
LPLWAVDAAVQWVFG	CXCR3	106	P49682
AAPGADGAWWRAQVV	AKAP1	766	Q92667
PLVVAEGGTAWLEWR	CSPG4	436	Q6UVK1
EGGTAWLEWRHVQPT	CSPG4	441	Q6UVK1
VTVRALLHVWAGGPW	CSPG4	2041	Q6UVK1
PGRIQLWGHGIAVDW	A1CF	201	Q9NQ94
AVLGPDGRWVRWAVL	AFDN-DT	41	Q9Y6Z5
VPEWWLVILGCIRAG	ACSM2A	116	Q08AH3
WVVESIAGFLRGPDW	CFAP36	11	Q96G28
PRHETWVVGWIQACN	FAM78B	61	Q5VT40
IRWGDAWAVGPVTIA	GRM2	561	Q14416
RWEDAWAIGPVTIAC	GRM3	571	Q14832
GDRVWVRGWFPILFE	ARFGEF2	1321	Q9Y6D5
IAKRIPVQAVWAGWG	ACACA	196	Q13085
LLRAWLVLGVAPDDW	ARMC5	591	Q96C12
LIRLRNPWGEVEWSG	CAPN8	281	A6NHC0
GWIHTVCINGRWDPE	CFH	786	P08603
GPWARDIQRAGAWEL	DLL3	156	Q9NYJ7
VWVQVACPRLSIDWG	DPH1	341	Q9BZG8
APLGARWVCINGVWV	CCDC74A	111	Q96AQ1
APLGARWVCINGVWV	CCDC74B	111	Q96LY2
LGELRSWWEVPAIAH	CECR2	11	Q9BXF3
WQPVTAVGEGLDRVW	ANTKMT	181	Q9BQD7
PAHWVFWVGPIVGAV	AQP5	201	P55064
ARLIVWNGPLGVFEW	PGK2	331	P07205
PGRIQLWGHQIAVDW	RBM47	216	A0AV96
IWSGWHRRTEELPLG	QPCTL	51	Q9NXS2
RIGGADFLVWRWIQP	LEMD3	736	Q9Y2U8
RIPVQAVWAGWGHAS	ACACB	341	O00763
WGWEVAGAPALRLQK	MISP	526	Q8IVT2
GLEPQSGWLWVRAAL	DCHS1	1046	Q96JQ0
PRLCWQLASVAWVIG	OR2H2	136	O95918
SAGLAVIDWEDWRPV	HYAL2	126	Q12891
ATWLPFARAAAVGWL	KCND1	6	Q9NSA2
FVPGGWWHVVLNLDT	JMJD6	266	Q6NYC1
WEVLNAIGPWSALAG	MAGEC3	296	Q8TD91
TAVALGAVAWRRAWP	MTARC1	31	Q5VT66
WLPQWHCGVRVVSSR	NMT1	206	P30419
FREIGWHDWIIQPEG	INHBC	256	P55103
AWVAGATAAVPVVPW	LRRN2	11	O75325
HVARVGPLPWLWAAR	IL17RE	531	Q8NFR9
PVLSRPRAWVAVHWQ	KCNK7	146	Q9Y2U2
PRAWVAVHWQLSPAR	KCNK7	151	Q9Y2U2
GAWPPAHALRAWLAV	MGAT5B	681	Q3V5L5
LAVRWTEAWLLGPVA	FFAR4	96	Q5NUL3
RITVRVAGPWLWVAV	ICAM5	826	Q9UMF0
VHPGQILIWAIWVLA	CES5A	6	Q6NT32
DVWAFSPLGRGHWEL	MEGF8	306	Q7Z7M0
VWLREQIVHGGAPIW	MARCHF6	161	O60337
RLPLWVCAGVWVLAT	GPR152	146	Q8TDT2
VVGLTWGHISWDLLA	METTL23	76	Q86XA0
PSVVQGWGHLLQAVW	ANKRD65	36	E5RJM6
RIPFLIHWSWPLQGE	NLRX1	26	Q86UT6
GLEWVAVIWRGESHQ	IGHV8-51-1	61	P0DTE2
WAPLVDAQGSARAWV	MFSD3	56	Q96ES6
PGWLAEAIVTWRGHL	DXO	121	O77932
DHIWVTRWLDDIGLP	PPFIBP2	631	Q8ND30
VHRPDCWVTGWGLIS	PRSS41	176	Q7RTY9
KGRTGWPQHVWALEL	HAND2	201	P61296
PVGVLWPWLAEVHVA	PRSS36	596	Q5K4E3
WPWLAEVHVAGDRVC	PRSS36	601	Q5K4E3
GLWAASFILALPVWV	MCHR2	156	Q969V1
WVQVLAEGWATPLNG	PAPSS1	266	O43252
ASWVRPGVLWDVALV	GP9	141	P14770
VAVWLTWANGAINPV	GPR135	371	Q8IZ08
LGWIGAIVSTALPQW	CLDN1	16	O95832
HWVLQWPGQVVICVS	DNAH3	1276	Q8TD57
VPSVADILQIGWWAT	CACNA2D1	921	P54289
PGFFELVVRVLWWIG	DAGLB	21	Q8NCG7
LAFVQGLVWNTWGPI	SLC49A4	61	Q96SL1
RPAVWLNAGIHSREW	CPA4	171	Q9UI42
VIWFHPTWAQQIREG	C5orf22	96	Q49AR2
ALAKWAEGRTGFPWI	CRY1	326	Q16526
LWAPGGHTIAWDVIT	FANCC	496	Q00597
LWAFHVVSWGVPLVI	GPR157	121	Q5UAW9
APGTVWWAADHRQVQ	DNAAF8	286	Q8IYS4
IGLAWLVSFVLWAPA	CHRM1	146	P11229
LEWIAGWLPRHCIGA	ADCY9	856	O60503
AAVALGTVAWRRAWP	MTARC2	31	Q969Z3
PVHLWGTEEVAAWLE	DGKD	1141	Q16760
AGSGWAWRPVARDAL	KLHDC9	11	Q8NEP7
DWVIPANAGLGTWRT	MECR	126	Q9BV79
VPWRWALALLALVGA	EMILIN2	11	Q9BXX0
QRVSWPAIGFLVLAW	CTNS	231	O60931
DLTSIPVRHQLWEGW	FAF1	226	Q9UNN5
RWALWSVGGEVHVAL	GPR146	91	Q96CH1
WPARPALVLVWESGL	HPS6	86	Q86YV9
LVLGWFGWDVPVILR	CGRRF1	31	Q99675
WVGPSWRTQAVVLAQ	SLC22A13	216	Q9Y226
GWKVPLEQVSHLLGW	SLC22A31	126	A6NKX4
WRVTWAHPEFGQVLA	SEH1L	61	Q96EE3
VFGRFPITGAWWRVK	HELB	76	Q8NG08
RVVAATEGWWRLGTP	FUZ	186	Q9BT04
EHIWIILDGPVDAIW	DNAH5	2331	Q8TE73
DGWLIRIGVWTIAVL	LGR5	556	O75473
RAAWWGEVPRADLIV	POTEA	71	Q6S8J7
LLALGVRAVRSEWWG	MUC3B	1156	Q9H195
IQLWPVARERAGWTH	MROH5	526	Q6ZUA9
WRNALEAWAVPVVLG	FUT3	261	P21217
LVRVHGDPAVWWVSQ	FUT8	316	Q9BYC5
GWEVFDVWQGLRHQP	GDF6	211	Q6KF10
ADLRGHEGPVWQVAW	SEC13	51	P55735
WPRWALIAGALAAGV	SYT8	46	Q8NBV8
PGDLVWINAGTVHWV	UTY	1161	O14607
GHWGGEVLIVASWVL	SLC52A3	391	Q9NQ40
VVAKPGVWARLGSWA	TIMM29	21	Q9BSF4
WDWALPVAKLAIRVG	TMEM161A	216	Q9NX61
GWPGLFLESARWLIV	SLC22A17	231	Q8WUG5
VLRLGWPVDSAWKGI	FAM83E	111	Q2M2I3
PRLWVLVVLGTSWVG	F5	6	P12259
VARLWWRGILGASAL	NDUFS3	6	O75489
WRVPHTGVNRTVWEL	RNF128	51	Q8TEB7
AGDWHWALRVSPVLG	SPNS2	256	Q8IVW8
GVLRKPDAWIGLWGV	MTRES1	11	Q9P0P8
RVVRALWPGGCALAW	PTGES2	6	Q9H7Z7
PWLHASVLWAGVASL	HRC	6	P23327
GLGIGAEVWWNLVPR	SEMA4C	16	Q9C0C4
AVVAERGWRHSLWVP	SOWAHB	556	A6NEL2
WAHLGVQVWQRAECP	STRA6	181	Q9BX79
WVQAIRRVIWAPLGG	ARHGAP22	136	Q7Z5H3
LGAVLWPAAGAWELT	NT5E	16	P21589
GRWAHVVCALWIPEV	BRPF1	346	P55201
WVVALVVSVGPLLGW	ADRA1D	221	P25100
VPEWWLVILGCIRAG	ACSM2B	116	Q68CK6
WPVWLGVHDRRAEGL	CLEC11A	236	Q9Y240
DQWIWFEGLPTRIHL	TP53TG5	206	Q9Y2B4
DLANAVHWLPRGVLW	PEX11G	191	Q96HA9
TRLQRTWGVWHVPEL	RINL	41	Q6ZS11
GVLLHPEWSLATGWR	TIMM50	156	Q3ZCQ8
LGVCLPWHWEGWRQV	nan	51	Q6ZSR3
QWTALVTGLREPGWA	SPEG	1331	Q15772
PLLSDQAWHVGTWGL	PAPLN	481	O95428
LSGAGRRLWDWVPLA	MRPL51	6	Q4U2R6
GQPVWPVAVALTLRW	SLC27A5	21	Q9Y2P5
GAPHWVAVGLLTWAT	SLC39A7	6	Q92504
WHWALRVTPGLGVVA	SPNS1	216	Q9H2V7
RGLHAWEISWPLEQR	SPSB2	86	Q99619
WEISWPLEQRGTHAV	SPSB2	91	Q99619
LQGRDWVPLHSGEWA	SYT15B	136	X6R8R1
IRGLWAGWVPNIQRA	SLC25A27	186	O95847
VLTLWVWALAPAGAV	TMDD1	11	P0DPE3
RVDGLVPGLSWWNVF	TMEM203	36	Q969S6
LRPEEGVWAVRLAWG	TRIM10	396	Q9UDY6
PQLLHICIEGWGNWR	VPS13B	2671	Q7Z7G8
TLGVRHDWTWLAPLA	SCN11A	906	Q9UI33
VWVRHLEAAGPRVSW	TMC6	696	Q7Z403
LEAAGPRVSWLPWVH	TMC6	701	Q7Z403
GLGVLAWQRWRAIPA	TEX28	371	O15482
VLLALWVWPSTQAGH	THBS2	6	P35442
CIPLWVGARGIEFDW	TMEM147	116	Q9BVK8
VSIATRIRWHWGQEP	TSPY26P	266	Q9H489
LAVLVLLLWGAPWTH	TMX1	11	Q9H3N1
WWAQEITELAQGPGR	PLD2	301	O14939
WPVVAAVWRHLLPAL	TMEM239	136	Q8WW34
GSGAHWNRPVLVAWA	AVPR2	151	P30518
LEWLRGIGWVPIGSV	NEB	3631	P20929