Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionallyl-alcohol dehydrogenase activity

AKR1B10 AKR1B15 AKR1B1

8.80e-084573GO:0047655
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1B10 AKR1B15 AKR1B1

7.85e-0614573GO:0001758
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1B10 AKR1B15 AKR1B1

7.85e-0614573GO:0004032
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NADP+) activity

AKR1B10 AKR1B15 AKR1B1

9.79e-0615573GO:0052650
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1B10 AKR1B15

4.79e-054572GO:0047718
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1B10 AKR1B15 AKR1B1

6.14e-0527573GO:0008106
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1B10 AKR1B15 AKR1B1

1.03e-0432573GO:0004033
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1B10 AKR1B15

1.19e-046572GO:0045550
GeneOntologyMolecularFunctionNADP+ binding

AKR1B10 AKR1B15

2.85e-049572GO:0070401
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1B10 AKR1B15 AKR1B1

3.48e-0448573GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

CYP4A11 AKR1B10 AKR1B15 AKR1B1

4.75e-04127574GO:0016616
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1B10 AKR1B15 AKR1B1

5.49e-0456573GO:0016903
GeneOntologyMolecularFunctioninsulin-like growth factor I binding

IGF1R ITGB4

6.12e-0413572GO:0031994
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

CYP4A11 AKR1B10 AKR1B15 AKR1B1

6.49e-04138574GO:0016614
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase adaptor activity

SH2B3 GAB4

1.19e-0318572GO:0005068
GeneOntologyMolecularFunctioninsulin-like growth factor binding

IGF1R ITGB4

1.33e-0319572GO:0005520
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1B10 AKR1B15

1.47e-0320572GO:0004303
GeneOntologyMolecularFunctionprotein kinase activity

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2 LMTK3

1.53e-03600577GO:0004672
GeneOntologyMolecularFunctionretinal binding

AKR1B10 AKR1B15

1.62e-0321572GO:0016918
GeneOntologyMolecularFunctionmyosin binding

LMTK2 LIMCH1 USH2A

1.85e-0385573GO:0017022
GeneOntologyMolecularFunctionNADPH binding

AKR1B10 AKR1B15

2.49e-0326572GO:0070402
GeneOntologyMolecularFunctionprotein serine kinase activity

STK3 MYO3A SPEG LMTK2 LMTK3

3.73e-03363575GO:0106310
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2 LMTK3

3.91e-03709577GO:0016773
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1B10 AKR1B15

3.99e-0333572GO:0033764
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GBGT1 GALNT6

4.48e-0335572GO:0008376
GeneOntologyMolecularFunctionaromatase activity

CYP1B1 CYP4A11

4.48e-0335572GO:0070330
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1B10 AKR1B15

5.54e-0339572GO:0016229
GeneOntologyMolecularFunctionkinase activity

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2 LMTK3

5.85e-03764577GO:0016301
GeneOntologyMolecularFunctionoxidoreductase activity

CYP1B1 P3H3 CYP4A11 AKR1B10 AKR1B15 AKR1B1 QSOX2

5.94e-03766577GO:0016491
GeneOntologyMolecularFunctionsignaling adaptor activity

SH2B3 GAB4 IFNAR2

5.98e-03129573GO:0035591
GeneOntologyMolecularFunctionG-protein alpha-subunit binding

IGF1R RGS7

6.71e-0343572GO:0001965
GeneOntologyMolecularFunctionretinoid binding

AKR1B10 AKR1B15

8.30e-0348572GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

AKR1B10 AKR1B15

8.64e-0349572GO:0019840
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP1B1 CYP4A11

8.64e-0349572GO:0016712
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

STK3 MYO3A SPEG LMTK2 LMTK3

8.78e-03446575GO:0004674
GeneOntologyMolecularFunctionsignaling receptor complex adaptor activity

SH2B3 GAB4

1.04e-0254572GO:0030159
GeneOntologyMolecularFunctionvitamin binding

P3H3 AKR1B10 AKR1B15

1.10e-02161573GO:0019842
GeneOntologyMolecularFunctioniron ion binding

CYP1B1 P3H3 CYP4A11

1.19e-02166573GO:0005506
GeneOntologyBiologicalProcessretinol metabolic process

CYP1B1 AKR1B10 AKR1B15 AKR1B1

1.39e-0553574GO:0042572
GeneOntologyBiologicalProcesscellular response to aldehyde

IGF1R AKR1B10 AKR1B1

2.21e-0520573GO:0110096
GeneOntologyBiologicalProcessretinoid metabolic process

CYP1B1 AKR1B10 AKR1B15 AKR1B1

1.07e-0489574GO:0001523
GeneOntologyBiologicalProcessditerpenoid metabolic process

CYP1B1 AKR1B10 AKR1B15 AKR1B1

1.33e-0494574GO:0016101
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP1B1 CYP4A11 AKR1B10 AKR1B15 AKR1B1

1.39e-04180575GO:0120254
GeneOntologyBiologicalProcesscellular response to progesterone stimulus

CYP1B1 IGF1R

1.56e-047572GO:0071393
GeneOntologyBiologicalProcessterpenoid metabolic process

CYP1B1 AKR1B10 AKR1B15 AKR1B1

2.04e-04105574GO:0006721
GeneOntologyBiologicalProcessprimary alcohol metabolic process

CYP1B1 AKR1B10 AKR1B15 AKR1B1

2.11e-04106574GO:0034308
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1B10 AKR1B1

2.67e-049572GO:0044597
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1B10 AKR1B1

3.33e-0410572GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1B10 AKR1B1

3.33e-0410572GO:0030647
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1B10 AKR1B1

3.33e-0410572GO:0044598
GeneOntologyBiologicalProcessregulation of receptor signaling pathway via JAK-STAT

CYP1B1 SH2B3 AKR1B1 IFNAR2

3.96e-04125574GO:0046425
GeneOntologyBiologicalProcessretina vasculature morphogenesis in camera-type eye

CYP1B1 ARHGEF15

4.06e-0411572GO:0061299
DomainALDOKETO_REDUCTASE_1

AKR1B10 AKR1B15 AKR1B1

3.19e-0610573PS00798
DomainAldo/ket_reductase_CS

AKR1B10 AKR1B15 AKR1B1

3.19e-0610573IPR018170
DomainAldo/keto_reductase

AKR1B10 AKR1B15 AKR1B1

3.19e-0610573IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1B10 AKR1B15 AKR1B1

3.19e-0610573PS00062
DomainALDOKETO_REDUCTASE_3

AKR1B10 AKR1B15 AKR1B1

3.19e-0610573PS00063
Domain-

AKR1B10 AKR1B15 AKR1B1

1.47e-05165733.20.20.100
DomainNADP_OxRdtase_dom

AKR1B10 AKR1B15 AKR1B1

1.78e-0517573IPR023210
DomainAldo_ket_red

AKR1B10 AKR1B15 AKR1B1

1.78e-0517573PF00248
DomainAldo/ket_red/Kv-b

AKR1B10 AKR1B15 AKR1B1

1.78e-0517573IPR001395
DomainFN3_dom

IGF1R SPEG USH2A ITGB4 IFNAR2

4.37e-04209575IPR003961
DomainPROTEIN_KINASE_DOM

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2 LMTK3

7.23e-04493577PS50011
Domain-

INTS6L HMCN1 ITGB4

1.50e-03745733.40.50.410
Domainfn3

IGF1R SPEG USH2A ITGB4

1.51e-03162574PF00041
DomainVWFA

INTS6L HMCN1 ITGB4

2.01e-0382573PS50234
DomainVWA

INTS6L HMCN1 ITGB4

2.16e-0384573SM00327
DomainFN3

IGF1R SPEG USH2A ITGB4

2.44e-03185574SM00060
DomainPROTEIN_KINASE_ATP

STK3 MYO3A IGF1R SPEG LMTK2 LMTK3

2.68e-03459576PS00107
DomainFN3

IGF1R SPEG USH2A ITGB4

3.18e-03199574PS50853
DomainPROTEIN_KINASE_TYR

IGF1R LMTK2 LMTK3

3.24e-0397573PS00109
DomainRICIN

GALNT6 LY75

3.29e-0328572SM00458
DomainRICIN_B_LECTIN

GALNT6 LY75

3.29e-0328572PS50231
DomainVWF_A

INTS6L HMCN1 ITGB4

3.44e-0399573IPR002035
DomainProt_kinase_dom

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2

3.66e-03489576IPR000719
DomainRicin_B_lectin

GALNT6 LY75

3.77e-0330572IPR000772
DomainProtein_kinase_ATP_BS

STK3 MYO3A IGF1R SPEG LMTK2

5.91e-03379575IPR017441
DomainKinase-like_dom

SCYL2 STK3 MYO3A IGF1R SPEG LMTK2

6.02e-03542576IPR011009
PathwayREACTOME_ESTROGEN_BIOSYNTHESIS

AKR1B10 AKR1B15

1.47e-047382MM14740
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

AKR1B10 AKR1B15 AKR1B1

1.79e-0441383MM14757
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP1B1 CYP4A11

2.52e-049382M27143
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

STK3 CDH24 IGF1R ITGB4

3.04e-04121384M39823
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP1B1 CYP4A11

3.83e-0411382MM14863
Pubmed

Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.

AKR1B10 AKR1B15 AKR1B1

4.88e-09360317381426
Pubmed

Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.

AKR1B10 AKR1B15 AKR1B1

4.87e-08560310092857
Pubmed

Impaired Barrier Function and Immunity in the Colon of Aldo-Keto Reductase 1B8 Deficient Mice.

AKR1B10 AKR1B15

2.93e-06260233644071
Pubmed

Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.

AKR1B10 AKR1B1

2.93e-06260212732097
Pubmed

Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.

AKR1B10 AKR1B15

2.93e-06260234954342
Pubmed

Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians.

AKR1B10 AKR1B1

2.93e-06260215745835
Pubmed

Aldo Keto Reductases AKR1B1 and AKR1B10 in Cancer: Molecular Mechanisms and Signaling Networks.

AKR1B10 AKR1B1

2.93e-06260233945128
Pubmed

Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry.

AKR1B10 AKR1B1

2.93e-06260228003428
Pubmed

Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway.

AKR1B10 AKR1B15

2.93e-06260225120755
Pubmed

Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.

AKR1B10 AKR1B15

2.93e-06260221087085
Pubmed

Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland.

AKR1B10 AKR1B15

2.93e-0626028526877
Pubmed

Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111).

AKR1B10 AKR1B1

2.93e-06260224100137
Pubmed

Decreased levels of AKR1B1 and AKR1B10 in cancerous endometrium compared to adjacent non-cancerous tissue.

AKR1B10 AKR1B1

2.93e-06260223146748
Pubmed

AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.

AKR1B10 AKR1B15

2.93e-06260236518763
Pubmed

Identification and characterization of a novel human aldose reductase-like gene.

AKR1B10 AKR1B1

2.93e-0626029565553
Pubmed

Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.

AKR1B10 AKR1B15

2.93e-06260225538260
Pubmed

Functional expression of novel human and murine AKR1B genes.

AKR1B10 AKR1B15

2.93e-06260221276782
Pubmed

Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer.

AKR1B10 AKR1B1

2.93e-06260228929377
Pubmed

Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis.

AKR1B10 AKR1B15

2.93e-06260231911858
Pubmed

Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.

AKR1B10 AKR1B1

2.93e-06260221329684
Pubmed

1.7 A structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor.

AKR1B10 AKR1B15

2.93e-0626027578036
Pubmed

Characterization of the promoter of the gene for a mouse vas deferens protein related to the aldo-keto reductase superfamily: effect of steroid hormones and phorbol esters.

AKR1B10 AKR1B15

2.93e-0626028541228
Pubmed

Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway.

AKR1B10 AKR1B1

2.93e-06260232628753
Pubmed

Aldo-keto reductases-mediated cytotoxicity of 2-deoxyglucose: A novel anticancer mechanism.

AKR1B10 AKR1B1

2.93e-06260229617059
Pubmed

A delayed-early gene activated by fibroblast growth factor-1 encodes a protein related to aldose reductase.

AKR1B10 AKR1B15

8.77e-0636027510692
Pubmed

Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family.

LMTK2 LMTK3

8.77e-06360217651901
Pubmed

Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross.

AKR1B10 AKR1B15

1.75e-05460221179467
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

IGF1R SH2B3 SPEG SIPA1L3 LMTK2 HECTD1 GCN1 ITGB4 ANKRD33B CREB3

1.79e-051105601035748872
Pubmed

Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.

AKR1B10 AKR1B15

2.92e-05560226291391
Pubmed

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

IGF1R ITGB4

4.37e-05660228873464
Pubmed

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.

SPEG SIPA1L3 HECTD1

5.34e-054260323444366
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1B10 AKR1B1

8.14e-05860220837989
Pubmed

Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.

CLGN CPEB1

1.05e-04960211702780
Pubmed

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

LIMCH1 RGS7

1.31e-041060225199915
Pubmed

Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain.

AKR1B10 AKR1B15

2.26e-041360233593819
Pubmed

Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage.

NUFIP2 GCN1

2.63e-041460236179369
Pubmed

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.

MYO3A HMCN1

4.40e-041860223534349
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STK3 FAM117A IGF1R SIPA1L3 LMTK2 LIMCH1 HECTD1

6.87e-0486160736931259
Pubmed

Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.

CYP1B1 FAM117A

9.99e-042760219208226
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

AKR1B10 AKR1B15 AKR1B1

1.02e-0311460328245920
Pubmed

The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.

CYP1B1 ITGB4

1.15e-032960219094228
Pubmed

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

FAM117A SIPA1L3 RAD54L2

1.25e-0312260330773093
Pubmed

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.

SCYL2 STK3 HMCN1

1.43e-0312860325332235
InteractionAKR1B15 interactions

AKR1B10 AKR1B15 AKR1B1

8.05e-0614583int:AKR1B15
CytobandEnsembl 112 genes in cytogenetic band chr7q33

AKR1B10 AKR1B15 AKR1B1

6.22e-0558603chr7q33
Cytoband5p15.2

DAP ANKRD33B

5.77e-04276025p15.2
Cytoband7q33

AKR1B10 AKR1B15

1.33e-03416027q33
GeneFamilyAldo-keto reductases

AKR1B10 AKR1B15 AKR1B1

3.83e-0615383399
GeneFamilyReceptor Tyrosine Kinases|CD molecules

IGF1R LMTK2 LMTK3

8.02e-0540383321
GeneFamilyFibronectin type III domain containing

IGF1R USH2A ITGB4

4.57e-03160383555
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CYP1B1 HMCN1 AKR1B10 AKR1B1 ITGB4

5.20e-061866052d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

CYP1B1 HMCN1 AKR1B10 AKR1B1 ITGB4

7.39e-0620060565b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellmLN-Dendritic_cell-Lymphoid_DC|Dendritic_cell / Region, Cell class and subclass

STK3 FAM117A LY75 GCN1 ANKRD33B

7.39e-062006053813fa1ee1462ba83fd8b6253070f46f0b063084
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

HMCN1 AKR1B10 AKR1B1 ITGB4 ARHGEF15

7.39e-06200605b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HMCN1 AKR1B10 AKR1B1 ITGB4 ARHGEF15

7.39e-06200605b1ff8d61b567f85006d6d20093f9c803b6d34674
DrugGlyceraldehyde

AKR1B10 AKR1B15 AKR1B1

1.86e-0610583ctd:D005985
DrugPentanones

AKR1B10 AKR1B1

6.38e-062582ctd:D010422
Drug4-hydroxyretinal

AKR1B10 AKR1B1

6.38e-062582ctd:C057180
Drug4-oxoretinaldehyde

AKR1B10 AKR1B1

6.38e-062582ctd:C099660
Drugpropioin

AKR1B10 AKR1B1

6.38e-062582ctd:C523189
Drugdehydroretinal

AKR1B10 AKR1B1

6.38e-062582ctd:C017184
Drugalrestatin

P3H3 AKR1B10 AKR1B1

6.98e-0615583CID000002120
DrugPyrithyldione [77-04-3]; Down 200; 24uM; MCF7; HT_HG-U133A

SCYL2 STK3 ADRA1D SH2B3 SIPA1L3 LIMCH1

1.05e-051965863482_DN
DrugD-arabinitol

ADAT3 DLGAP4 AKR1B10 GBGT1 AKR1B1

1.07e-05114585CID000000827
Drugbenzo(a)pyrene-7,8-dione

CYP1B1 AKR1B10 AKR1B1

1.73e-0520583ctd:C076588
Drugbenzo(a)pyrene-7,8-dione

CYP1B1 AKR1B10 AKR1B1

1.73e-0520583CID000105020
Drug2,4-hexadienal

AKR1B10 AKR1B1

1.91e-053582ctd:C079389
DrugAcetoin

AKR1B10 AKR1B1

1.91e-053582ctd:D000093
Drug2,3-butylene glycol

AKR1B10 AKR1B1

1.91e-053582ctd:C026978
Drug5-Isothiocyanatoalrestatin

AKR1B10 AKR1B1

3.81e-054582CID000124861
Drug5-azidoalrestatin

AKR1B10 AKR1B1

3.81e-054582CID000128442
Drug5-(3-Thienyl)tetrazol-1-yl)acetic acid

AKR1B10 AKR1B1

3.81e-054582CID003035658
DrugFR-62765

AKR1B10 AKR1B1

3.81e-054582CID000128354
DrugM7HEQ

AKR1B10 AKR1B1

3.81e-054582CID006452329
Drug2,5-DHBQOP

AKR1B10 AKR1B1

3.81e-054582CID000069213
DrugNAP-HEX-Q

AKR1B10 AKR1B1

3.81e-054582CID005487149
DrugWF-2421

AKR1B10 AKR1B1

3.81e-054582CID000195567
Drugdanshenol B

AKR1B10 AKR1B1

3.81e-054582CID003083515
Drug4-chloro-3-hydroxybutanoate

AKR1B10 AKR1B1

3.81e-054582CID010129995
Drugiodomethanesulfonamide

AKR1B10 AKR1B1

3.81e-054582CID000519939
Drugsalviaflaside

AKR1B10 AKR1B1

3.81e-054582CID006438919
Drugmatteuorienate A

AKR1B10 AKR1B1

3.81e-054582CID000190958
Drugzopolrestat

AKR1B10 AKR1B15 AKR1B1

4.39e-0527583CID000001613
DrugM79175

AKR1B10 AKR1B1

6.35e-055582CID000115090
Drugxanthone-2

AKR1B10 AKR1B1

6.35e-055582CID005384285
DrugAC1NE042

AKR1B10 AKR1B1

6.35e-055582CID004634410
DrugAC1L4VGL

AKR1B10 AKR1B1

6.35e-055582CID000213726
Drug4-chloro-3-nitrobenzaldehyde

AKR1B10 AKR1B1

6.35e-055582CID000085505
Drug2,3-hexanedione

AKR1B10 AKR1B1

6.35e-055582ctd:C043231
DrugICI 105552

AKR1B10 AKR1B1

6.35e-055582CID000133677
Drug2-(2,3,6-Trihydroxy-4-carboxyphenyl)ellagic acid

AKR1B10 AKR1B1

6.35e-055582CID006918808
DrugICI 222155

AKR1B10 AKR1B1

6.35e-055582CID000195716
DrugDN-108

AKR1B10 AKR1B1

6.35e-055582CID000183791
DrugAD-5467

AKR1B10 AKR1B1

6.35e-055582CID000197383
DrugBAL-ARI8

AKR1B10 AKR1B1

6.35e-055582CID000130098
Drugbenzo(a)pyrene 7,8-dihydrodiol

CYP1B1 AKR1B10 AKR1B1

6.70e-0531583ctd:C017228
Drugphenanthrene trans-1,2-dihydrodiol

AKR1B10 AKR1B1

9.50e-056582CID000115062
DrugICI 215918

AKR1B10 AKR1B1

9.50e-056582CID000129688
DrugAC1L28UN

AKR1B10 AKR1B1

9.50e-056582CID000068017
DrugM16287

AKR1B10 AKR1B1

9.50e-056582CID000188399
Drugp225

AKR1B10 AKR1B1

9.50e-056582CID000014589
DrugADN-138

AKR1B10 AKR1B1

9.50e-056582CID000127323
DrugBAPSG

AKR1B10 AKR1B1

9.50e-056582CID000130998
Drug1,2,4-triazol-3-one

AKR1B10 AKR1B1

9.50e-056582CID011073339
Drugcapillarisin

AKR1B10 AKR1B1

9.50e-056582CID005281342
Drug3,5-dichlorosalicylic acid

AKR1B10 AKR1B1

9.50e-056582CID000009445
Drugcelastrol; Down 200; 2.5uM; MCF7; HT_HG-U133A_EA

CYP1B1 IGF1R SIPA1L3 DLGAP4 IFNAR2

1.14e-04187585887_DN
Drug4-nitrobenzaldehyde

AKR1B15 AKR1B1

1.33e-047582ctd:C029915
Drugmyrciacitrin I

AKR1B10 AKR1B1

1.33e-047582CID000183137
Drugfriedelane

AKR1B10 AKR1B1

1.33e-047582CID000634354
Drug3-formylbenzoic acid

AKR1B10 AKR1B1

1.33e-047582CID000012077
Drugtetramethylene glutaric acid

AKR1B10 AKR1B1

1.33e-047582CID000085558
Drugguaijaverin

AKR1B10 AKR1B1

1.33e-047582CID005317847
Drugdesmanthin-1

AKR1B10 AKR1B1

1.33e-047582CID005316590
Drug5213008; Up 200; 18uM; MCF7; HT_HG-U133A_EA

CYP1B1 SH2B3 SIPA1L3 DLGAP4 LIMCH1

1.36e-04194585898_UP
Drugradicicol; Down 200; 0.1uM; MCF7; HG-U133A

CYP1B1 SIPA1L3 CEP41 TFB2M ARHGEF15

1.39e-04195585489_DN
DrugRoxithromycin [80214-83-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

SPEG SIPA1L3 LIMCH1 RAD54L2 ZNF646

1.42e-041965853331_UP
DrugEthoxyquin

CYP1B1 AKR1B10 AKR1B1

1.45e-0440583ctd:D005015
DrugDiloxanide furoate [3736-81-0]; Up 200; 12.2uM; PC3; HT_HG-U133A

CYP1B1 ADRA1D P3H3 TRAF3IP3 RGS7

1.46e-041975856679_UP
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A

CLGN IGF1R SIPA1L3 LIMCH1 ARHGEF15

1.46e-041975852308_UP
Druggenistein; Down 200; 10uM; PC3; HT_HG-U133A

STK3 CYP1B1 SPEG TMEM97 LIMCH1

1.49e-041985851235_DN
DrugTetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A

IGF1R DLGAP4 CEP41 LIMCH1 CPEB1

1.49e-041985854412_UP
DrugTiclopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; PC3; HT_HG-U133A

CYP1B1 IGF1R DLGAP4 ITGB4 RGS7

1.49e-041985854074_DN
DrugRimexolone [49697-38-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A

STK3 CYP1B1 IGF1R TMEM97 IFNAR2

1.53e-041995855517_DN
DrugPromethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

LMTK2 LIMCH1 TRAF3IP3 RAD54L2 ITGB4

1.56e-042005856477_UP
Drugerythritol 4-phosphate

AKR1B10 AKR1B1

1.77e-048582CID000192838
Drug4-hydroxynonanoate

AKR1B10 AKR1B1

1.77e-048582CID000134653
DrugRisarestat

AKR1B10 AKR1B1

1.77e-048582CID000133264
Drug6-pyridoxyllysine

AKR1B10 AKR1B1

1.77e-048582CID000160700
Drugpropranolol glycol

AKR1B10 AKR1B1

1.77e-048582CID000037369
Drug1,2-diaminoguanidine

AKR1B10 AKR1B1

1.77e-048582CID000170039
Drug20-CHO-LTB4

AKR1B10 AKR1B1

1.77e-048582CID006449839
DrugCP-166,572

AKR1B10 AKR1B1

1.77e-048582CID000132302
Drugalcophosphamide

AKR1B10 AKR1B1

1.77e-048582CID000098612
Drugeutypine

AKR1B10 AKR1B1

1.77e-048582CID000129326
DrugSG-210

AKR1B10 AKR1B1

1.77e-048582CID000132542
DrugNSC633676

AKR1B10 AKR1B1

1.77e-048582CID000133894
Drug3 Na

AKR1B10 AKR1B1

1.77e-048582CID000157838
Drugnaphthalene-1,2-dihydrodiol

CYP1B1 AKR1B10 AKR1B1

2.06e-0445583CID000000362
DrugSolvent Yellow-?14

CYP1B1 AKR1B10 AKR1B1

2.20e-0446583CID005354458
DrugAL3152

AKR1B10 AKR1B1

2.27e-049582CID000159501
DrugAC1Q5HJP

AKR1B10 AKR1B1

2.27e-049582CID000000067
Drug3-deoxyfructose

AKR1B10 AKR1B1

2.27e-049582CID003080627
Drugpotassium amyl xanthate

AKR1B10 AKR1B1

2.27e-049582CID000017635
Drugmetyrapol

AKR1B10 AKR1B1

2.27e-049582CID000161210
Drugmycaminose

AKR1B10 AKR1B1

2.83e-0410582CID000160504
Drug5-OH-VPA

CYP1B1 CYP4A11

2.83e-0410582CID000135243
Drugazapetine

ADRA1D AKR1B1

2.83e-0410582CID000008966
Drug2,3-hexanedione

AKR1B10 AKR1B1

2.83e-0410582CID000019707
DrugHexanones

AKR1B10 AKR1B1

2.83e-0410582ctd:D006588
Drug4-OH-VPA

CYP1B1 CYP4A11

2.83e-0410582CID000134466
Drug3-fluoro-3-deoxy-D-glucose

AKR1B10 AKR1B1

2.83e-0410582CID000122305
Druglys-val

AKR1B10 AKR1B1

2.83e-0410582CID000140709
DrugDB289

CYP1B1 CYP4A11

2.83e-0410582CID005480200
DrugDihydroxydihydrobenzopyrenes

AKR1B10 AKR1B1

3.46e-0411582ctd:D004101
Diseasealdose reductase measurement

AKR1B10 AKR1B1

2.35e-054592EFO_0801364
Diseasesymmetrical dimethylarginine measurement

AKR1B10 AKR1B15

1.40e-049592EFO_0006523
Diseasewhite matter growth measurement

AKR1B10 AKR1B1

1.40e-049592EFO_0009335
DiseaseEndometrial Neoplasms

IGF1R AKR1B10 AKR1B1

2.17e-0458593C0014170
Diseasediabetic neuropathy (implicated_via_orthology)

IGF1R AKR1B1

3.52e-0414592DOID:9743 (implicated_via_orthology)
DiseaseEndometrial Carcinoma

IGF1R AKR1B10 AKR1B1

4.11e-0472593C0476089
DiseaseX-24309 measurement

ADRA1D CYP4A11

7.30e-0420592EFO_0800872
Diseasetestosterone measurement

HMCN1 DLGAP4 NUFIP2 AKR1B15 DAP AKR1B1 USH2A ARHGEF15 IFNAR2

9.15e-041275599EFO_0004908
Diseaseuric acid measurement

IGF1R SIPA1L3 LMTK2 HFM1 AKR1B1 QSOX2

1.36e-03610596EFO_0004761
Diseasemean corpuscular hemoglobin concentration

FAM117A SH2B3 DLGAP4 HFM1 ZNF217 TRAF3IP3 LY75 ARHGEF15

1.54e-031105598EFO_0004528
DiseaseOvarian Mucinous Adenocarcinoma

MYO3A SPEG

1.76e-0331592C1335167
Diseasehyperuricemia

IGF1R SIPA1L3

1.99e-0333592EFO_0009104
Diseaselifestyle measurement, anxiety disorder measurement

ADRA1D GBGT1 USH2A

2.63e-03137593EFO_0007795, EFO_0010724
Diseasecataract (implicated_via_orthology)

SIPA1L3 AKR1B1

2.64e-0338592DOID:83 (implicated_via_orthology)
Diseaserosacea severity measurement

STK3 MYO3A IGF1R

3.21e-03147593EFO_0009180
Diseasediabetic retinopathy (biomarker_via_orthology)

IGF1R AKR1B1

3.68e-0345592DOID:8947 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PEPAPWQALPVLSEK

ADAT3

21

Q96EY9
DKDDQEWESPSPPKP

DAP

41

P51397
LPPRLLEKSDNPYPW

TBC1D32

886

Q96NH3
DPEASKASPLPFEPW

FAM117A

421

Q9C073
GPPLPAENKWRFTPE

CEP41

291

Q9BYV8
NPKVWPNPEVFDPFR

CYP4A11

421

Q02928
PDRPWAKPEDPSLLE

AKR1B10

216

O60218
SSAPNKPLDWLDPMP

LINC02910

101

Q8N268
IFWEPPAASLKPPAL

ARHGEF15

61

O94989
EFNMWLPPPEALPAD

RAD54L2

346

Q9Y4B4
ALEASSLPPPDPWLE

DLGAP4

771

Q9Y2H0
PDRPWAKPEDPSLLE

AKR1B1

216

P15121
CPEQFWEKYRPELPP

ANKRD33B

251

A6NCL7
EDPRFPKLQWPTPDL

QSOX2

521

Q6ZRP7
ESFWPDQNLPSLPPR

INTS6L

291

Q5JSJ4
FKDPDPWTPAALIPE

P3H3

401

Q8IVL6
DTWKTDQRPTPEPFP

FAM189A1

456

O60320
GSFEWAEDFPLLPPP

LMTK3

1411

Q96Q04
PLLVAEWSAPAAPPQ

CDH24

466

Q86UP0
EPRPENSIFLKWPEP

IGF1R

841

P08069
PLNFLNWDPDRPSAP

LY75

296

O60449
PTAANAPDPLPEDWK

LMTK2

1336

Q8IWU2
WANKDPLPPLDPQAI

GCN1

2576

Q92616
RPEKLKEPWPNSDPP

ITGB4

186

P16144
KEPWPNSDPPFSFKN

ITGB4

191

P16144
FPPPDLSWLKNEQPI

HMCN1

2991

Q96RW7
LAWPFPNLPPLEAMD

IFNAR2

286

P48551
PDNEKSLDWFLPPAP

HFM1

26

A2PYH4
WVPLPPSADDNLKTP

NPIPB11

886

E5RHQ5
EFILDPPKPKPPAWF

HECTD1

2326

Q9ULT8
PEYLWDDRKPQPPSL

GBGT1

316

Q8N5D6
PAELKPFWERPPQDP

GALNT6

96

Q8NCL4
ELCPPDPAFAPLSSW

GAB4

11

Q2WGN9
SPWKSPPQLRQFLPE

DENND6A

466

Q8IWF6
TFWPDSEPKPEQAPR

GLI4

71

P10075
SKWDQPAPAPLLFLP

KHDC4

16

Q7Z7F0
PSWDLLEAPKDPFSI

CPEB1

261

Q9BZB8
PLKWPNPENFDPARF

CYP1B1

431

Q16678
AEPPLEWPFPDLFSE

CREB3

321

O43889
PEPPPEPAFSEAQKW

LIMCH1

16

Q9UPQ0
LEAPPQDFPAPWAQA

USH2A

3961

O75445
FLLPPDPSNPWLSDD

RGS7

296

P49802
PLPKLFPRNWDDLDP

SSPOP

2176

A2VEC9
RWFDPLDPLEPEQDP

SIPA1L3

1286

O60292
PSEQEPKFPCKEWDP

SCYL2

206

Q6P3W7
PKFPCKEWDPNLPSL

SCYL2

211

Q6P3W7
LWPEPDFRNPPRKAS

TFB2M

51

Q9H5Q4
PDRPWAKPEDPSLLE

AKR1B15

216

C9JRZ8
PLLGWKEPVPPDERF

ADRA1D

231

P25100
GPWEPLALAPDFPAD

ANHX

256

E9PGG2
PAGWLDDEPKFIPDP

CLGN

311

O14967
LPVWSPKSFPNEVEP

TRAF3IP3

441

Q9Y228
NPPPTFRKPELWSDD

STK3

236

Q13188
APLWPQSPDASDFLP

TPRX1

331

Q8N7U7
EDSWTLFKPPPVFPV

NUFIP2

331

Q7Z417
WFRDGQLLPAPAPEP

SPEG

76

Q15772
PLLDPSPQWPADLSF

ZNF646

1816

O15015
KFLPWSLAREPPPEA

SH2B3

181

Q9UQQ2
DPLLQEPPAWFKSFL

TMEM97

56

Q5BJF2
PTPPLQLKWDRDEGP

nan

261

A8MUI8
PPPTEKDWPKDDEQD

WDR93

26

Q6P2C0
SIDYPAKNDSPWAPP

ZNF217

881

O75362
APATLLEEWDPVPKP

THEG

276

Q9P2T0
QLLPPEPDDAFWGAP

TMEM198

11

Q66K66
PPPKLRQPELWSAEF

MYO3A

246

Q8NEV4