Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	opsonin binding	CFHR1 C4A C4B CR1 CFHR4	4.54e-09	25	51	5	GO:0001846
GeneOntologyMolecularFunction	complement binding	CFHR1 C4A C4B CR1 CFHR4	1.70e-08	32	51	5	GO:0001848
GeneOntologyMolecularFunction	complement component C3b binding	CFHR1 CR1 CFHR4	3.40e-06	12	51	3	GO:0001851
GeneOntologyMolecularFunction	phospholipid transporter activity	PITPNM1 PITPNM2 ANO5 ANO3	3.81e-05	74	51	4	GO:0005548
GeneOntologyMolecularFunction	lipid transporter activity	PITPNM1 PITPNM2 ANO5 ANO3 CFHR4	1.41e-04	196	51	5	GO:0005319
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	2.84e-04	10	51	2	GO:0001849
GeneOntologyMolecularFunction	phosphatidylinositol transfer activity	PITPNM1 PITPNM2	3.47e-04	11	51	2	GO:0008526
GeneOntologyMolecularFunction	Wnt receptor activity	FZD6 FZD3	8.49e-04	17	51	2	GO:0042813
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO5 ANO3	1.18e-03	20	51	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO5 ANO3	1.18e-03	20	51	2	GO:0005229
GeneOntologyMolecularFunction	phosphatidylcholine transporter activity	PITPNM1 PITPNM2	1.18e-03	20	51	2	GO:0008525
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO5 ANO3	1.56e-03	23	51	2	GO:0017128
GeneOntologyMolecularFunction	receptor tyrosine kinase binding	PITPNM1 PITPNM2 GAS6	1.58e-03	90	51	3	GO:0030971
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	FZD6 HLTF TOLLIP GSK3B AXIN1	1.65e-03	337	51	5	GO:0031625
GeneOntologyMolecularFunction	phospholipid transfer activity	PITPNM1 PITPNM2	2.00e-03	26	51	2	GO:0120014
GeneOntologyMolecularFunction	ubiquitin-like protein ligase binding	FZD6 HLTF TOLLIP GSK3B AXIN1	2.15e-03	358	51	5	GO:0044389
GeneOntologyMolecularFunction	phosphatidylcholine binding	PITPNM1 PITPNM2	3.41e-03	34	51	2	GO:0031210
GeneOntologyMolecularFunction	Wnt-protein binding	FZD6 FZD3	3.41e-03	34	51	2	GO:0017147
GeneOntologyMolecularFunction	quaternary ammonium group binding	PITPNM1 PITPNM2	6.16e-03	46	51	2	GO:0050997
GeneOntologyMolecularFunction	protein tyrosine kinase binding	PITPNM1 PITPNM2 GAS6	6.53e-03	149	51	3	GO:1990782
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO5 ANO3	7.24e-03	50	51	2	GO:0099095
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO5 ANO3	7.53e-03	51	51	2	GO:0140303
GeneOntologyBiologicalProcess	positive regulation of mRNA splicing, via spliceosome	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.11e-09	44	51	6	GO:0048026
GeneOntologyBiologicalProcess	positive regulation of mRNA processing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.17e-09	49	51	6	GO:0050685
GeneOntologyBiologicalProcess	positive regulation of RNA splicing	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.03e-08	63	51	6	GO:0033120
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.93e-08	129	51	7	GO:0048024
GeneOntologyBiologicalProcess	regulation of mRNA processing	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.18e-07	158	51	7	GO:0050684
GeneOntologyBiologicalProcess	regulation of RNA splicing	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	7.38e-07	207	51	7	GO:0043484
GeneOntologyBiologicalProcess	complement activation	CFHR1 C4A C4B CR1 CFHR4	8.10e-07	70	51	5	GO:0006956
GeneOntologyBiologicalProcess	positive regulation of mRNA metabolic process	PDE12 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	3.28e-06	259	51	7	GO:1903313
GeneOntologyBiologicalProcess	mRNA processing	RBM15 PDE12 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E VIRMA	7.27e-06	551	51	9	GO:0006397
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	RBM15 PDE12 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.20e-05	443	51	8	GO:1903311
GeneOntologyBiologicalProcess	midbrain morphogenesis	FZD6 FZD3	1.80e-05	3	51	2	GO:1904693
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.69e-05	358	51	7	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.69e-05	358	51	7	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	2.88e-05	362	51	7	GO:0000375
GeneOntologyBiologicalProcess	RNA splicing	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E VIRMA	2.96e-05	502	51	8	GO:0008380
GeneOntologyBiologicalProcess	mRNA metabolic process	RBM15 PDE12 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E HLTF VIRMA	6.98e-05	917	51	10	GO:0016071
GeneOntologyBiologicalProcess	activation of membrane attack complex	CR1 CFHR4	8.93e-05	6	51	2	GO:0001905
GeneOntologyBiologicalProcess	regulation of complement activation, alternative pathway	CR1 CFHR4	1.25e-04	7	51	2	GO:0030451
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	1.66e-04	8	51	2	GO:2000427
GeneOntologyBiologicalProcess	cell proliferation in midbrain	FZD6 FZD3	1.66e-04	8	51	2	GO:0033278
GeneOntologyBiologicalProcess	complement activation, classical pathway	C4A C4B CR1	1.76e-04	44	51	3	GO:0006958
GeneOntologyBiologicalProcess	immune complex clearance	CR1 CFHR4	2.13e-04	9	51	2	GO:0002434
GeneOntologyBiologicalProcess	apoptotic cell clearance	GAS6 C4A C4B	2.28e-04	48	51	3	GO:0043277
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	2.66e-04	10	51	2	GO:2000425
GeneOntologyBiologicalProcess	regulation of complement-dependent cytotoxicity	CR1 CFHR4	4.59e-04	13	51	2	GO:1903659
GeneOntologyBiologicalProcess	humoral immune response mediated by circulating immunoglobulin	C4A C4B CR1	4.86e-04	62	51	3	GO:0002455
GeneOntologyBiologicalProcess	negative regulation of synapse assembly	GSK3B EPHA7	6.17e-04	15	51	2	GO:0051964
GeneOntologyBiologicalProcess	cellular response to interferon-alpha	PDE12 GAS6	6.17e-04	15	51	2	GO:0035457
GeneOntologyBiologicalProcess	organophosphate ester transport	PITPNM1 PITPNM2 CR1 ANO3	6.87e-04	162	51	4	GO:0015748
GeneOntologyBiologicalProcess	complement-dependent cytotoxicity	CR1 CFHR4	7.04e-04	16	51	2	GO:0097278
GeneOntologyBiologicalProcess	male gonad development	RBMY1A1 RBMY1D RBMY1B RBMY1E	8.41e-04	171	51	4	GO:0008584
GeneOntologyBiologicalProcess	development of primary male sexual characteristics	RBMY1A1 RBMY1D RBMY1B RBMY1E	8.60e-04	172	51	4	GO:0046546
GeneOntologyBiologicalProcess	protein localization to cilium	WDR35 GSK3B DNAH11	9.16e-04	77	51	3	GO:0061512
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CR1 CFHR4	9.98e-04	19	51	2	GO:0006957
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B CFHR4	8.06e-07	8	52	3	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B CFHR4	1.21e-06	9	52	3	GO:0044217
GeneOntologyCellularComponent	spliceosomal complex	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	1.51e-05	215	52	6	GO:0005681
GeneOntologyCellularComponent	male germ cell nucleus	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.22e-05	86	52	4	GO:0001673
GeneOntologyCellularComponent	germ cell nucleus	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.79e-04	113	52	4	GO:0043073
GeneOntologyCellularComponent	RNA N6-methyladenosine methyltransferase complex	RBM15 VIRMA	2.16e-04	9	52	2	GO:0036396
GeneOntologyCellularComponent	beta-catenin destruction complex	GSK3B AXIN1	4.65e-04	13	52	2	GO:0030877
GeneOntologyCellularComponent	Wnt signalosome	GSK3B AXIN1	7.12e-04	16	52	2	GO:1990909
GeneOntologyCellularComponent	cell body	PITPNM1 PITPNM2 FZD3 C4A C4B GSK3B EPHA7 CFHR4	1.96e-03	929	52	8	GO:0044297
MousePheno	abnormal choline level	PNPLA7 SLC25A48	6.42e-05	5	36	2	MP:0030752
MousePheno	absent ribs	WDR35 AXIN1	6.42e-05	5	36	2	MP:0000151
Domain	RBM1CTR	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	6.91e-12	8	51	5	PF08081
Domain	RBM1CTR	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	6.91e-12	8	51	5	IPR012604
Domain	RRM_1	RBM15 RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.11e-05	208	51	6	PF00076
Domain	RRM	RBM15 RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.67e-05	217	51	6	SM00360
Domain	RRM_dom	RBM15 RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	3.44e-05	227	51	6	IPR000504
Domain	RRM	RBM15 RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	3.70e-05	230	51	6	PS50102
Domain	Nucleotide-bd_a/b_plait	RBM15 RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	7.01e-05	258	51	6	IPR012677
Domain	Anaphylatoxin_comp_syst	C4A C4B	7.27e-05	5	51	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	7.27e-05	5	51	2	IPR001840
Domain	IP_trans	PITPNM1 PITPNM2	7.27e-05	5	51	2	PF02121
Domain	LNS2	PITPNM1 PITPNM2	1.09e-04	6	51	2	PF08235
Domain	LNS2	PITPNM1 PITPNM2	1.09e-04	6	51	2	IPR013209
Domain	PI_transfer	PITPNM1 PITPNM2	1.09e-04	6	51	2	IPR001666
Domain	LNS2	PITPNM1 PITPNM2	1.09e-04	6	51	2	SM00775
Domain	DDHD	PITPNM1 PITPNM2	1.09e-04	6	51	2	PF02862
Domain	DDHD	PITPNM1 PITPNM2	1.09e-04	6	51	2	PS51043
Domain	LNS2/PITP	PITPNM1 PITPNM2	1.09e-04	6	51	2	IPR031315
Domain	DDHD_dom	PITPNM1 PITPNM2	1.09e-04	6	51	2	IPR004177
Domain	DDHD	PITPNM1 PITPNM2	1.09e-04	6	51	2	SM01127
Domain	ANATO	C4A C4B	1.52e-04	7	51	2	SM00104
Domain	ANATO	C4A C4B	1.52e-04	7	51	2	PF01821
Domain	Anoct_dimer	ANO5 ANO3	1.52e-04	7	51	2	PF16178
Domain	Anoct_dimer	ANO5 ANO3	1.52e-04	7	51	2	IPR032394
Domain	ANAPHYLATOXIN_2	C4A C4B	1.52e-04	7	51	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.52e-04	7	51	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	1.52e-04	7	51	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	2.03e-04	8	51	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	2.03e-04	8	51	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	2.03e-04	8	51	2	IPR019742
Domain	A2M_N	C4A C4B	3.24e-04	10	51	2	PF01835
Domain	A2M_N	C4A C4B	3.24e-04	10	51	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	3.24e-04	10	51	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	3.24e-04	10	51	2	PS00477
Domain	A2M	C4A C4B	3.24e-04	10	51	2	PF00207
Domain	A2M_N_2	C4A C4B	3.24e-04	10	51	2	IPR011625
Domain	A2M_comp	C4A C4B	3.24e-04	10	51	2	IPR011626
Domain	A2M_N_2	C4A C4B	3.24e-04	10	51	2	PF07703
Domain	Anoctamin	ANO5 ANO3	3.24e-04	10	51	2	PF04547
Domain	Anoctamin	ANO5 ANO3	3.24e-04	10	51	2	IPR007632
Domain	A2M_recep	C4A C4B	3.24e-04	10	51	2	PF07677
Domain	A2M_comp	C4A C4B	3.24e-04	10	51	2	PF07678
Domain	Macroglobln_a2	C4A C4B	3.24e-04	10	51	2	IPR001599
Domain	Sushi	CFHR1 CR1 CFHR4	3.86e-04	52	51	3	PF00084
Domain	Frizzled	FZD6 FZD3	3.96e-04	11	51	2	IPR000539
Domain	Frizzled	FZD6 FZD3	3.96e-04	11	51	2	PF01534
Domain	Frizzled	FZD6 FZD3	3.96e-04	11	51	2	SM01330
Domain	CCP	CFHR1 CR1 CFHR4	4.31e-04	54	51	3	SM00032
Domain	SUSHI	CFHR1 CR1 CFHR4	4.80e-04	56	51	3	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR1 CR1 CFHR4	5.06e-04	57	51	3	IPR000436
Domain	-	RBM15 RBMY1F RBMY1D RBMY1B RBMY1E	5.26e-04	244	51	5	3.30.70.330
Domain	Frizzled/SFRP	FZD6 FZD3	8.56e-04	16	51	2	IPR015526
Domain	C345C	C4A C4B	9.68e-04	17	51	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	1.09e-03	18	51	2	IPR008930
Domain	NTR	C4A C4B	1.21e-03	19	51	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	1.21e-03	19	51	2	IPR018933
Domain	FRI	FZD6 FZD3	1.35e-03	20	51	2	SM00063
Domain	-	FZD6 FZD3	1.49e-03	21	51	2	1.10.2000.10
Domain	NTR	C4A C4B	1.78e-03	23	51	2	PS50189
Domain	-	PITPNM1 PITPNM2	1.78e-03	23	51	2	3.30.530.20
Domain	Netrin_domain	C4A C4B	1.78e-03	23	51	2	IPR001134
Domain	START-like_dom	PITPNM1 PITPNM2	1.78e-03	23	51	2	IPR023393
Domain	Frizzled_dom	FZD6 FZD3	1.94e-03	24	51	2	IPR020067
Domain	FZ	FZD6 FZD3	1.94e-03	24	51	2	PS50038
Domain	Fz	FZD6 FZD3	1.94e-03	24	51	2	PF01392
Domain	TIMP-like_OB-fold	C4A C4B	2.28e-03	26	51	2	IPR008993
Domain	Mit_carrier	SLC25A48 SLC25A45	3.44e-03	32	51	2	IPR002067
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD6 FZD3 GSK3B AXIN1	6.95e-06	44	40	4	MM15878
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	FZD6 FZD3 GSK3B AXIN1	7.61e-06	45	40	4	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	FZD6 FZD3 GSK3B AXIN1	8.32e-06	46	40	4	M47409
Pathway	PID_BETA_CATENIN_DEG_PATHWAY	SSPOP GSK3B AXIN1	1.68e-05	18	40	3	M31
Pathway	KEGG_BASAL_CELL_CARCINOMA	FZD6 FZD3 GSK3B AXIN1	1.71e-05	55	40	4	M17807
Pathway	REACTOME_COMPLEMENT_CASCADE	CFHR1 C4A C4B CR1 CFHR4	1.73e-05	115	40	5	M19752
Pathway	WP_WNT_SIGNALING	FZD6 FZD3 GSK3B AXIN1	2.58e-05	61	40	4	MM15893
Pathway	WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS	FZD6 FZD3 GSK3B AXIN1	3.53e-05	66	40	4	M39642
Pathway	REACTOME_SYNTHESIS_OF_PI	PITPNM1 PITPNM2	7.81e-05	5	40	2	MM14587
Pathway	REACTOME_SYNTHESIS_OF_PI	PITPNM1 PITPNM2	7.81e-05	5	40	2	M26962
Pathway	REACTOME_COMPLEMENT_CASCADE	CFHR1 C4A C4B CFHR4	9.10e-05	84	40	4	MM14653
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	FZD6 FZD3 GSK3B AXIN1	1.14e-04	89	40	4	M39563
Pathway	WNT_SIGNALING	FZD6 FZD3 GSK3B AXIN1	1.14e-04	89	40	4	M5493
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR1 CFHR4	1.17e-04	6	40	2	M47880
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	FZD6 GSK3B AXIN1	1.19e-04	34	40	3	M27405
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.63e-04	7	40	2	MM14685
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	FZD6 FZD3 GSK3B AXIN1	1.66e-04	98	40	4	M39731
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	FZD6 FZD3 GSK3B AXIN1	1.86e-04	101	40	4	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	FZD6 FZD3 GSK3B AXIN1	1.86e-04	101	40	4	M39387
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	2.17e-04	8	40	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	2.17e-04	8	40	2	M47872
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	GAS6 C4A C4B CR1	2.24e-04	106	40	4	M42535
Pathway	WP_WNT_SIGNALING_WP428	FZD6 FZD3 GSK3B AXIN1	2.86e-04	113	40	4	M39669
Pathway	PID_PS1_PATHWAY	SSPOP GSK3B AXIN1	2.95e-04	46	40	3	M70
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	FZD6 FZD3 GSK3B AXIN1	3.16e-04	116	40	4	MM15863
Pathway	WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS	FZD6 FZD3 GSK3B AXIN1	3.27e-04	117	40	4	M39530
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_AXIN_TO_WNT_SIGNALING_PATHWAY	GSK3B AXIN1	3.48e-04	10	40	2	M47486
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	4.25e-04	11	40	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	4.25e-04	11	40	2	M47874
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY	GSK3B AXIN1	5.09e-04	12	40	2	M47410
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	5.09e-04	12	40	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	6.00e-04	13	40	2	M4732
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ANO5 ANO3	6.00e-04	13	40	2	M46426
Pathway	BIOCARTA_PS1_PATHWAY	GSK3B AXIN1	6.99e-04	14	40	2	MM1459
Pathway	BIOCARTA_PS1_PATHWAY	GSK3B AXIN1	6.99e-04	14	40	2	M16173
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD6 FZD3	6.99e-04	14	40	2	M47834
Pathway	BIOCARTA_PITX2_PATHWAY	GSK3B AXIN1	8.05e-04	15	40	2	MM1439
Pathway	REACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS	GSK3B AXIN1	8.05e-04	15	40	2	M27407
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	8.05e-04	15	40	2	M7146
Pathway	KEGG_WNT_SIGNALING_PATHWAY	FZD6 FZD3 GSK3B AXIN1	8.57e-04	151	40	4	M19428
Pathway	BIOCARTA_PITX2_PATHWAY	GSK3B AXIN1	9.19e-04	16	40	2	M8516
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	FZD6 FZD3	9.19e-04	16	40	2	M47823
Pathway	WP_BREAST_CANCER_PATHWAY	FZD6 FZD3 GSK3B AXIN1	9.22e-04	154	40	4	M39739
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	C4A C4B CR1	9.74e-04	69	40	3	M16894
Pathway	REACTOME_LATE_SARS_COV_2_INFECTION_EVENTS	ANO5 ANO3 GSK3B	1.02e-03	70	40	3	M46438
Pathway	WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS	GSK3B AXIN1	1.04e-03	17	40	2	M39525
Pathway	WP_MAP3K1_ROLE_IN_PROMOTING_AND_BLOCKING_GONADAL_DETERMINATION	GSK3B AXIN1	1.04e-03	17	40	2	M39907
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	GSK3B AXIN1	1.04e-03	17	40	2	M27083
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.04e-03	17	40	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.04e-03	17	40	2	MM1369
Pathway	REACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE	GSK3B AXIN1	1.17e-03	18	40	2	MM14759
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	FZD6 FZD3	1.30e-03	19	40	2	M47833
Pathway	PID_WNT_CANONICAL_PATHWAY	GSK3B AXIN1	1.44e-03	20	40	2	M90
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.44e-03	20	40	2	M917
Pathway	BIOCARTA_GSK3_PATHWAY	GSK3B AXIN1	1.44e-03	20	40	2	M11106
Pathway	BIOCARTA_GSK3_PATHWAY	GSK3B AXIN1	1.75e-03	22	40	2	MM1421
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	1.75e-03	22	40	2	M39502
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	FZD6 FZD3 GSK3B	1.78e-03	85	40	3	M48315
Pathway	BIOCARTA_WNT_PATHWAY	GSK3B AXIN1	1.91e-03	23	40	2	MM1527
Pathway	BIOCARTA_WNT_PATHWAY	GSK3B AXIN1	2.08e-03	24	40	2	M16517
Pathway	PID_MYC_PATHWAY	GSK3B AXIN1	2.26e-03	25	40	2	M139
Pathway	WP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA	FZD6 GSK3B	2.44e-03	26	40	2	M39407
Pathway	WP_COMPLEMENT_SYSTEM	C4A CR1 CFHR4	2.52e-03	96	40	3	M39581
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	FZD3 GSK3B AXIN1	2.59e-03	97	40	3	MM15926
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	FZD3 GSK3B AXIN1	2.91e-03	101	40	3	M39448
Pathway	KEGG_MELANOGENESIS	FZD6 FZD3 GSK3B	2.91e-03	101	40	3	M7761
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	GSK3B AXIN1	3.47e-03	31	40	2	M27400
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	GSK3B AXIN1	3.47e-03	31	40	2	MM15154
Pathway	WP_WNT_SIGNALING_PATHWAY	FZD6 GSK3B AXIN1	3.70e-03	110	40	3	MM15977
Pathway	REACTOME_SIGNALING_BY_WNT	FZD6 FZD3 GSK3B AXIN1	4.56e-03	239	40	4	MM14756
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD6 FZD3	4.65e-03	36	40	2	M39699
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	GAS6 C4A C4B	4.72e-03	120	40	3	MM14982
Pathway	BIOCARTA_ALK_PATHWAY	GSK3B AXIN1	4.91e-03	37	40	2	M17400
Pathway	WP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING	GSK3B AXIN1	4.91e-03	37	40	2	M39817
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	GSK3B AXIN1	4.91e-03	37	40	2	M47411
Pathway	WP_ALZHEIMERS_DISEASE	FZD6 FZD3 GSK3B AXIN1	6.22e-03	261	40	4	M42565
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	C4A C4B	6.29e-03	42	40	2	MM15945
Pathway	REACTOME_CA2_PATHWAY	FZD6 FZD3	7.20e-03	45	40	2	MM15040
Pathway	PID_HEDGEHOG_GLI_PATHWAY	SSPOP GSK3B	8.15e-03	48	40	2	M219
Pubmed	A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	5.79e-17	7	52	6	8269511
Pubmed	Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.	RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	7.60e-15	12	52	6	9598316
Pubmed	RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	3.67e-14	6	52	5	15184870
Pubmed	RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.	RBM15 RBMY1A1 RBMY1D RBMY1B RBMY1E	1.28e-13	7	52	5	17001072
Pubmed	Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene.	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	1.28e-13	7	52	5	8875892
Pubmed	Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.22e-11	5	52	4	20016065
Pubmed	An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.22e-11	5	52	4	8817321
Pubmed	The role of human and mouse Y chromosome genes in male infertility.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.22e-11	5	52	4	11097427
Pubmed	Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.22e-11	5	52	4	19737860
Pubmed	Identification of target messenger RNA substrates for mouse RBMY.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.65e-11	6	52	4	18492746
Pubmed	Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.65e-11	6	52	4	12356914
Pubmed	The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.65e-11	6	52	4	18239052
Pubmed	Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.65e-11	6	52	4	9499427
Pubmed	Does Rbmy have a role in sperm development in mice?	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.65e-11	6	52	4	15051956
Pubmed	The roles of RNA-binding proteins in spermatogenesis and male infertility.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.55e-10	7	52	4	10377282
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.10e-10	8	52	4	7479793
Pubmed	Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.	RBMY1A1 RBMY1D RBMY1B RBMY1E	9.27e-10	10	52	4	10601091
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	RBMY1A1 RBMY1D RBMY1B RBMY1E	9.27e-10	10	52	4	9384609
Pubmed	Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.	C4A C4B CR1 CFHR4	1.45e-09	11	52	4	23204401
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.18e-09	12	52	4	20543856
Pubmed	GASZ promotes germ cell derivation from embryonic stem cells.	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.14e-09	13	52	4	23816659
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	RBMY1A1 RBMY1C RBMY1F RBMY1B	3.14e-09	13	52	4	10749975
Pubmed	Absence of mDazl produces a final block on germ cell development at meiosis.	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.40e-09	14	52	4	14611631
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	RBMY1A1 RBMY1D RBMY1B RBMY1E	5.99e-09	15	52	4	14762062
Pubmed	Loss of maternal Trim28 causes male-predominant early embryonic lethality.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.04e-08	17	52	4	28115466
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.34e-08	18	52	4	12023983
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	SZT2 RBMY1A1 RBMY1D RBMY1B RBMY1E	2.02e-08	55	52	5	19468303
Pubmed	Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.	C4A C4B CFHR4	6.28e-08	6	52	3	16849499
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.48e-08	26	52	4	35920200
Pubmed	Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.	C4A C4B CR1	1.76e-07	8	52	3	14670299
Pubmed	Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.	FZD3 GSK3B AXIN1	2.63e-07	9	52	3	19038973
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	SAMD9 RBMY1A1 RBMY1D RBMY1B RBMY1E	3.21e-07	95	52	5	24029230
Pubmed	Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.	C4A C4B CR1	6.87e-07	12	52	3	18524992
Pubmed	Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.	FZD6 FZD3 GSK3B	1.74e-06	16	52	3	22625652
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.90e-06	59	52	4	11279525
Pubmed	H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17.	C4A C4B AXIN1	2.11e-06	17	52	3	6816725
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.19e-06	2	52	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.19e-06	2	52	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.19e-06	2	52	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.19e-06	2	52	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.19e-06	2	52	2	17728371
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.19e-06	2	52	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.19e-06	2	52	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.19e-06	2	52	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.19e-06	2	52	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.19e-06	2	52	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.19e-06	2	52	2	1357031
Pubmed	Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.	RBMY1A1 RBMY1B	2.19e-06	2	52	2	32473614
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.19e-06	2	52	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.19e-06	2	52	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.19e-06	2	52	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.19e-06	2	52	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.19e-06	2	52	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	2.19e-06	2	52	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.19e-06	2	52	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.19e-06	2	52	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.19e-06	2	52	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.19e-06	2	52	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	2.19e-06	2	52	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	2.19e-06	2	52	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	2.19e-06	2	52	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	2.19e-06	2	52	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.19e-06	2	52	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.19e-06	2	52	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	2.19e-06	2	52	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.19e-06	2	52	2	7365238
Pubmed	Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.	FZD6 FZD3	2.19e-06	2	52	2	24816679
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.19e-06	2	52	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.19e-06	2	52	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	2.19e-06	2	52	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.19e-06	2	52	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	2.19e-06	2	52	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.19e-06	2	52	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.19e-06	2	52	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	2.19e-06	2	52	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	2.19e-06	2	52	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	2.19e-06	2	52	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	2.19e-06	2	52	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	2.19e-06	2	52	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.19e-06	2	52	2	29928053
Pubmed	Glycogen synthase kinase-3 and Axin function in a beta-catenin-independent pathway that regulates neurite outgrowth in neuroblastoma cells.	GSK3B AXIN1	2.19e-06	2	52	2	14664817
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.19e-06	2	52	2	17971229
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	2.19e-06	2	52	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.19e-06	2	52	2	6881182
Pubmed	Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.	GSK3B AXIN1	2.19e-06	2	52	2	17601533
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	2.19e-06	2	52	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.19e-06	2	52	2	23749435
Pubmed	Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.	GSK3B AXIN1	2.19e-06	2	52	2	12554650
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.19e-06	2	52	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	2.19e-06	2	52	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	2.19e-06	2	52	2	15390104
Pubmed	A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.	GSK3B AXIN1	2.19e-06	2	52	2	10581160
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.19e-06	2	52	2	3037333
Pubmed	Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β.	VIRMA GSK3B	2.19e-06	2	52	2	38658662
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.19e-06	2	52	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.19e-06	2	52	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.19e-06	2	52	2	17921792
Pubmed	The interaction of soluble human complement receptor type 1 (sCR1, BRL55730) with human complement component C4.	C4A CR1	2.19e-06	2	52	2	8422437
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.19e-06	2	52	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	2.19e-06	2	52	2	1699796
Cytoband	Yq11.223	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	7.37e-08	93	52	5	Yq11.223
Cytoband	1q32	CFHR1 CR1 CFHR4	2.43e-05	49	52	3	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chrYq11	RBMY1A1 RBMY1F RBMY1D RBMY1B RBMY1E	2.77e-05	311	52	5	chrYq11
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR1 CFHR4	3.31e-03	75	52	2	chr1q31
GeneFamily	Complement system\|Sushi domain containing	CFHR1 C4A C4B CR1 CFHR4	2.14e-08	36	43	5	492
GeneFamily	RNA binding motif containing	RBM15 RBMY1A1 RBMY1C RBMY1F RBMY1D RBMY1B RBMY1E	6.42e-07	213	43	7	725
GeneFamily	Phosphatidylinositol transfer proteins	PITPNM1 PITPNM2	8.24e-05	6	43	2	1151
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B CR1	9.20e-05	37	43	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.97e-04	9	43	2	1234
GeneFamily	Anoctamins	ANO5 ANO3	2.46e-04	10	43	2	865
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD6 FZD3	3.00e-04	11	43	2	286
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR1 CR1 CFHR4	3.35e-04	57	43	3	1179
GeneFamily	Olfactory receptors, family 10	OR10G6 OR10G3	1.08e-02	66	43	2	157
Coexpression	CHEN_ETV5_TARGETS_TESTIS	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.89e-07	33	48	4	MM701
Coexpression	ZHENG_IL22_SIGNALING_DN	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.40e-06	45	48	4	MM763
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	FZD6 PITPNM2 RBMY1A1 RBMY1D RBMY1B RBMY1E C4A C4B	1.21e-05	600	48	8	MM1025
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 SSPOP ANO3 EPHA7 DNAH11	1.61e-06	184	48	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 SSPOP ANO3 EPHA7 DNAH11	1.61e-06	184	48	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO5 SSPOP ANO3 EPHA7 DNAH11	1.61e-06	184	48	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Club_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	CFHR1 PLPP2 RHOV EPHA7	2.72e-05	161	48	4	342f5c61d37df61b35c18f5d258043a8f5cef629
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FRMPD1 GAS6 PNPLA7 H6PD	3.29e-05	169	48	4	0589f39d8e9468e42d25d30ff70bb7cb8b921628
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 APBA2 RNASE12 C4A	4.58e-05	184	48	4	da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA12 FZD3 APBA2 ARID3C	4.77e-05	186	48	4	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP2 RHOV GAS6 SLC25A48	5.40e-05	192	48	4	f3133bbbf938a39062a9b1d1181003bb48174695
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Club\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFHR1 PLPP2 RHOV CFHR4	5.40e-05	192	48	4	044c7ae56da17cacf2705efa8ac2c8aeba6cfeee
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP2 RHOV GAS6 SLC25A48	5.51e-05	193	48	4	c13e2612330ca8b9a8c206e588b26025c4f5898c
ToppCell	NS-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CA12 PLPP2 RHOV PNCK	5.73e-05	195	48	4	b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CA12 PLPP2 RHOV PNCK	5.97e-05	197	48	4	a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNM2 PNCK EPHA7 DNAH11	6.08e-05	198	48	4	c12e7511628db819a52959bb68580e27c00c2e41
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	PLPP2 RHOV PNCK EPHA7	6.08e-05	198	48	4	686eda427b075e788de38149eae82faf19bd5704
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLPP2 RHOV PNCK EPHA7	6.08e-05	198	48	4	a54ae5275a510b49d7629f0908817a0c5f05020e
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNM2 PNCK EPHA7 DNAH11	6.08e-05	198	48	4	22e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PLPP2 RHOV PNCK EPHA7	6.08e-05	198	48	4	34997e3896d0893fbe51bfb0d4660ccaca1c975e
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	C19orf67 SSPOP SLC25A48	7.58e-05	76	48	3	efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	C19orf67 SSPOP SLC25A48	7.58e-05	76	48	3	254d18bece2676faa4bbeb8d48b1d327ab3c2215
Computational	Complement.	CFHR1 C4A C4B	2.42e-05	23	27	3	MODULE_130
Drug	hydantoin-5-propionic acid	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.20e-07	21	50	4	CID000000782
Drug	AZFd	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.77e-07	23	50	4	CID000196489
Drug	Vistar	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.15e-06	36	50	4	CID000040896
Drug	2-chlorodideoxyadenosine	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.38e-06	43	50	4	CID000072194
Drug	PKI166	RBMY1A1 RBMY1D RBMY1B RBMY1E	3.73e-06	48	50	4	CID006918403
Drug	HgCl	RBMY1A1 RBMY1D RBMY1B RBMY1E	4.05e-06	49	50	4	CID000024182
Drug	azafagomine	RBMY1A1 RBMY1D RBMY1B RBMY1E	7.46e-06	57	50	4	CID011957435
Drug	2-aminothiophenol	C4A C4B	1.42e-05	3	50	2	ctd:C005464
Drug	thioglycolate	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.42e-05	67	50	4	CID000001133
Drug	SU6668	RBMY1A1 RBMY1D RBMY1B RBMY1E	1.70e-05	70	50	4	CID000206042
Drug	p11-13	RBMY1A1 RBMY1D RBMY1B RBMY1E	2.23e-05	75	50	4	CID000015759
Drug	oligoadenylate	PDE12 RBMY1A1 RBMY1D RBMY1B RBMY1E	2.41e-05	157	50	5	CID000107918
Drug	bipy	RBMY1A1 RBMY1D RBMY1B RBMY1E	6.13e-05	97	50	4	CID000001474
Drug	5-aza-2'-deoxycytidine	FZD3 RBMY1A1 RBMY1D RBMY1B APBA2 RBMY1E HLTF EPHA7	6.91e-05	638	50	8	CID000016886
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	PITPNM1 SAMD9 PDE12 AXIN1 EPHA7	6.95e-05	196	50	5	7137_UP
Drug	2-oyl	RBMY1A1 RBMY1D RBMY1B RBMY1E	8.35e-05	105	50	4	CID000657137
Disease	Complement deficiency disease	CFHR1 C4A C4B CFHR4	1.41e-07	33	42	4	C0272242
Disease	zinc finger protein 329 measurement	CFHR1 CFHR4	1.98e-06	2	42	2	EFO_0803276
Disease	leucine-rich repeat-containing protein 19 measurement	CFHR1 CFHR4	1.98e-06	2	42	2	EFO_0801762
Disease	phosphopantothenoylcysteine decarboxylase measurement	CFHR1 CFHR4	1.98e-06	2	42	2	EFO_0802867
Disease	protein FAM209B measurement	CFHR1 CFHR4	1.98e-06	2	42	2	EFO_0802943
Disease	level of otoraplin in blood serum	CFHR1 CFHR4	1.98e-06	2	42	2	OBA_2042720
Disease	soluble transferrin receptor measurement	CFHR1 CFHR4	5.93e-06	3	42	2	EFO_0004460
Disease	calnexin measurement	CFHR1 CFHR4	5.93e-06	3	42	2	EFO_0801444
Disease	histone-lysine N-methyltransferase 2D measurement	CFHR1 CFHR4	5.93e-06	3	42	2	EFO_0801683
Disease	complement factor H-related protein 4A measurement	CFHR1 CFHR4	5.93e-06	3	42	2	EFO_0600057
Disease	level of alpha-N-acetylglucosaminidase in blood serum	CFHR1 CFHR4	5.93e-06	3	42	2	OBA_2042500
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFHR1 CFHR4	1.18e-05	4	42	2	EFO_0803292
Disease	kallikrein-5 measurement	CFHR1 CFHR4	1.18e-05	4	42	2	EFO_0020515
Disease	complement C1s subcomponent measurement	CFHR1 CFHR4	2.96e-05	6	42	2	EFO_0008091
Disease	DNA repair protein XRCC4 measurement	CFHR1 CFHR4	5.51e-05	8	42	2	EFO_0801532
Disease	Hemolytic-uremic syndrome	CFHR1 CFHR4	7.08e-05	9	42	2	cv:C0019061
Disease	Atypical hemolytic-uremic syndrome	CFHR1 CFHR4	7.08e-05	9	42	2	cv:C2931788
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFHR1 CFHR4	7.08e-05	9	42	2	EFO_0801766
Disease	hemopexin measurement	CFHR1 CFHR4	1.08e-04	11	42	2	EFO_0008149
Disease	colorectal adenocarcinoma (is_marker_for)	CA12 GSK3B	6.79e-04	27	42	2	DOID:0050861 (is_marker_for)
Disease	complement factor H-related protein 2 measurement	CFHR1 CFHR4	7.84e-04	29	42	2	EFO_0600055
Disease	Age related macular degeneration	CFHR1 CFHR4	8.39e-04	30	42	2	C0242383
Disease	Eczema	PITPNM2 RNASE12 H6PD CFHR4	9.77e-04	310	42	4	HP_0000964
Disease	age of onset of Alzheimer disease	CR1 ANO3	1.02e-03	33	42	2	OBA_2001000
Disease	lung cancer (is_marker_for)	CA12 AXIN1	1.42e-03	39	42	2	DOID:1324 (is_marker_for)
Disease	Graves' disease (is_implicated_in)	C4A C4B	1.42e-03	39	42	2	DOID:12361 (is_implicated_in)
Disease	colon cancer (biomarker_via_orthology)	GSK3B AXIN1	1.42e-03	39	42	2	DOID:219 (biomarker_via_orthology)
Disease	Alzheimer disease, age at onset	FZD6 SZT2 PNPLA7 ANO3	1.42e-03	343	42	4	EFO_0004847, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
PYLCTGYDLYVTREP	ADAT3	276	Q96EY9
FITCRYRDYRYPPDD	ANO5	801	Q75V66
PASATLYDYYNPERR	C4B	1551	P0C0L5
YLYPYECETRALSSP	ARID3C	196	A6NKF2
YECPVYRTKLRGPSY	DNAH11	4476	Q96DT5
PEEEEGITYYIRYCP	APBA2	91	Q99767
DYIPRFVYEYKYGPC	ANO3	836	Q9BYT9
YAPFAYTYVRPRSLR	OR2L2	251	Q8NH16
QETRDYAPPSRGYAY	RBMY1A1	226	P0DJD3
QETRDYAPPSRGYAY	RBMY1B	226	A6NDE4
QETRDYAPPSRGYAY	RBMY1C	226	P0DJD4
QETRDYAPPSRGYAY	RBMY1D	226	P0C7P1
QETRDYAPPSRGYAY	RBMY1E	226	A6NEQ0
QETRDYAPPSRGYAY	RBMY1F	226	Q15415
RDYPFYERVRPAYSL	RBM15	331	Q96T37
AEYYRYRGSLTTPPC	CA12	216	O43570
YAPFAYTYLCPRSLR	OR2L5	251	Q8NG80
EFSRTVLYPYCAPYA	PDE12	311	Q6L8Q7
VYYVPCAFIYLRPET	OR10G3	251	Q8NGC4
FYCGDDSIRYPYRPD	PLPP2	36	O43688
AYPYTRTRFTCPFVE	PITPNM2	91	Q9BZ72
YYRAPSDPPYVACTR	EPHA7	316	Q15375
DYCEYLRPPIDSYST	PNPLA7	1166	Q6ZV29
ISYILLCGYPPFYDE	PNCK	201	Q6P2M8
RFRYPERPIIYYSVC	FZD6	226	O60353
YECRPEYYGRPFSIT	CR1	521	P17927
YECRPEYYGRPFSIT	CR1	971	P17927
VCYYDREPYLALGAP	FRMPD1	866	Q5SYB0
NDPETDYFYPRYLDC	GAS6	81	Q14393
AYYFCGEPIPYRTLV	AXIN1	786	O15169
EPNVSYICSRYYRAP	GSK3B	211	P49841
YICSRYYRAPELIFG	GSK3B	216	P49841
YCAPTAYTASRFPRY	C19orf67	216	A6NJJ6
LYYENTRRPYFPVAT	CFHR4	281	Q92496
YPRCIFPFIYRGKAY	ELSPBP1	71	Q96BH3
FRYPERPIIFYAVCY	FZD3	231	Q9NPG1
FYVYYGPDRIREPAL	HLTF	506	Q14527
YPSGERVRYECRSPY	CFHR1	166	Q03591
YTYRFGGRVPSLAYP	ETV2	316	O00321
SPLSDYYAYSPVRER	H6PD	441	O95479
YPACRYHYSPTEGFV	RNASE12	116	Q5GAN4
PASATLYDYYNPERR	C4A	1551	P0C0L4
VYYVPCTFIYLRPCS	OR10G6	271	Q8NH81
CRRAAPTGYEEFYFP	MUC3B	1066	Q9H195
YFFYCPPSSRREDEG	SZT2	1456	Q5T011
PCYYCRQRYVPGDTV	SSPOP	526	A2VEC9
CVSYPFDEFSNPYRY	SAMD9	161	Q5K651
LRDVPGYCLYFIPYV	SLC25A48	186	Q6ZT89
AYPYTRTRYTCPFVE	PITPNM1	91	O00562
YTCNGYPARYRPTAL	RHOV	51	Q96L33
YFITYEGLCRQYTPE	SLC25A45	181	Q8N413
YCRLRLGYAVYETPT	TOLLIP	76	Q9H0E2
YAYTRPDRPEYCVVF	WDR35	346	Q9P2L0
YDRELVPLLYFSCPY	VIRMA	341	Q69YN4