Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

1.02e-05749156GO:0005509
GeneOntologyBiologicalProcessregulation of nervous system development

MEGF8 EZH2 LRP4 NOTCH2 TG

5.87e-05625155GO:0051960
GeneOntologyBiologicalProcesspositive regulation by symbiont of entry into host

TMPRSS2 FURIN

5.89e-0516152GO:0075294
GeneOntologyBiologicalProcesspositive regulation of viral entry into host cell

TMPRSS2 FURIN

5.89e-0516152GO:0046598
GeneOntologyBiologicalProcessviral translation

TMPRSS2 FURIN

9.31e-0520152GO:0019081
GeneOntologyBiologicalProcessembryonic limb morphogenesis

MEGF8 LRP4 NOTCH2

1.55e-04148153GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

MEGF8 LRP4 NOTCH2

1.55e-04148153GO:0035113
GeneOntologyBiologicalProcesspositive regulation of viral life cycle

TMPRSS2 FURIN

1.71e-0427152GO:1903902
GeneOntologyBiologicalProcessappendage morphogenesis

MEGF8 LRP4 NOTCH2

2.98e-04185153GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

MEGF8 LRP4 NOTCH2

2.98e-04185153GO:0035108
GeneOntologyBiologicalProcessembryo development

MEGF8 LRP4 LRP1B THBD FURIN NOTCH2

3.27e-041437156GO:0009790
GeneOntologyBiologicalProcessregulation of neurogenesis

MEGF8 EZH2 LRP4 NOTCH2

4.21e-04515154GO:0050767
GeneOntologyBiologicalProcesslimb development

MEGF8 LRP4 NOTCH2

5.22e-04224153GO:0060173
GeneOntologyBiologicalProcessappendage development

MEGF8 LRP4 NOTCH2

5.22e-04224153GO:0048736
GeneOntologyBiologicalProcessregulation of viral entry into host cell

TMPRSS2 FURIN

7.17e-0455152GO:0046596
GeneOntologyBiologicalProcessmodulation by symbiont of entry into host

TMPRSS2 FURIN

9.10e-0462152GO:0052372
GeneOntologyBiologicalProcesszymogen activation

THBD FURIN

1.00e-0365152GO:0031638
GeneOntologyBiologicalProcessregulation of platelet activation

THBD SVEP1

1.03e-0366152GO:0010543
GeneOntologyBiologicalProcessprotein processing

TMPRSS2 THBD FURIN

1.05e-03285153GO:0016485
GeneOntologyBiologicalProcesspositive regulation of viral process

TMPRSS2 FURIN

1.13e-0369152GO:0048524
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

MEGF8 LRP4 SVEP1 FURIN NOTCH2

1.15e-031186155GO:0007167
GeneOntologyBiologicalProcessmorphogenesis of an epithelial sheet

MEGF8 NOTCH2

1.29e-0374152GO:0002011
GeneOntologyBiologicalProcessembryonic digit morphogenesis

MEGF8 LRP4

1.29e-0374152GO:0042733
GeneOntologyBiologicalProcessregulation of biological process involved in symbiotic interaction

TMPRSS2 FURIN

1.33e-0375152GO:0043903
GeneOntologyBiologicalProcessdetermination of heart left/right asymmetry

MEGF8 NOTCH2

1.47e-0379152GO:0061371
GeneOntologyBiologicalProcessembryonic heart tube morphogenesis

MEGF8 NOTCH2

1.51e-0380152GO:0003143
GeneOntologyBiologicalProcesspositive regulation of small GTPase mediated signal transduction

LRP4 NOTCH2

1.99e-0392152GO:0051057
GeneOntologyBiologicalProcesskidney development

EZH2 LRP4 NOTCH2

2.25e-03372153GO:0001822
GeneOntologyBiologicalProcessinflammatory response to antigenic stimulus

FURIN NOTCH2

2.49e-03103152GO:0002437
GeneOntologyBiologicalProcessembryonic heart tube development

MEGF8 NOTCH2

2.49e-03103152GO:0035050
GeneOntologyBiologicalProcessrenal system development

EZH2 LRP4 NOTCH2

2.50e-03386153GO:0072001
MousePhenoabnormal femur compact bone thickness

EZH2 LRP4 NOTCH2

8.48e-0723123MP:0013622
MousePhenoabnormal limb morphology

MEGF8 EZH2 LRP4 SVEP1 FURIN NOTCH2 TG

6.50e-061028127MP:0002109
MousePhenoincreased femur compact bone thickness

EZH2 LRP4

1.42e-057122MP:0013623
MousePhenoabnormal femur morphology

EZH2 LRP4 NOTCH2 TG

2.40e-05214124MP:0000559
MousePhenoabnormal hindlimb stylopod morphology

EZH2 LRP4 NOTCH2 TG

2.45e-05215124MP:0003856
MousePhenolimbs/digits/tail phenotype

MEGF8 EZH2 LRP4 SVEP1 FURIN NOTCH2 TG

2.48e-051258127MP:0005371
MousePhenoabnormal appendicular skeleton morphology

MEGF8 EZH2 LRP4 SSPOP NOTCH2 TG

4.51e-05896126MP:0009250
MousePhenoincreased growth rate

EZH2 TG

7.05e-0515122MP:0002865
MousePhenoabnormal compact bone thickness

EZH2 LRP4 NOTCH2

1.35e-04122123MP:0000134
MousePhenoabnormal myocardial trabeculae morphology

MEGF8 EZH2 NOTCH2

2.20e-04144123MP:0002189
MousePhenoabnormal trabecular bone connectivity density

LRP4 NOTCH2

2.34e-0427122MP:0010931
MousePhenoincreased bone ossification

LRP4 NOTCH2

3.30e-0432122MP:0020039
MousePhenoabnormal heart layer morphology

MEGF8 EZH2 THBD NOTCH2

3.34e-04422124MP:0010545
MousePhenobrachydactyly

LRP4 FURIN

3.51e-0433122MP:0002544
MousePhenoabnormal compact bone morphology

EZH2 LRP4 NOTCH2

3.71e-04172123MP:0003797
MousePhenoabnormal vibrissa morphology

LRP4 KLF16 FURIN

4.59e-04185123MP:0002098
MousePhenoimpaired branching involved in ureteric bud morphogenesis

LRP4 NOTCH2

5.44e-0441122MP:0004936
MousePhenoincreased compact bone thickness

EZH2 LRP4

5.44e-0441122MP:0004148
MousePhenorenal hypoplasia

MEGF8 NOTCH2

6.26e-0444122MP:0003446
MousePhenoabnormal branching involved in ureteric bud morphogenesis

LRP4 NOTCH2

6.55e-0445122MP:0010981
MousePhenoabnormal bone trabecular spacing

LRP4 NOTCH2

7.45e-0448122MP:0013629
MousePhenoskin edema

SVEP1 NOTCH2

9.09e-0453122MP:0001786
MousePhenoabnormal limb long bone morphology

EZH2 LRP4 NOTCH2 TG

1.03e-03568124MP:0011504
MousePhenoabnormal ureteric bud morphology

LRP4 NOTCH2

1.05e-0357122MP:0006032
MousePhenoabnormal hindlimb morphology

EZH2 LRP4 NOTCH2 TG

1.08e-03576124MP:0000556
MousePhenoabnormal limb bone morphology

EZH2 LRP4 NOTCH2 TG

1.16e-03587124MP:0002115
MousePhenoabnormal skeleton physiology

MEGF8 EZH2 LRP4 NOTCH2

1.53e-03632124MP:0001533
MousePhenoprolonged QRS complex duration

KLF16 SVEP1

1.72e-0373122MP:0010392
MousePhenointraventricular block

KLF16 SVEP1

1.76e-0374122MP:0010560
MousePhenobundle branch block

KLF16 SVEP1

1.76e-0374122MP:0010636
DomainGrowth_fac_rcpt_

MEGF8 LRP4 LRP1B THBD SVEP1 FURIN NOTCH2

1.51e-11156157IPR009030
DomainEGF_CA

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

3.86e-1186156PF07645
DomainEGF_Ca-bd_CS

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

8.09e-1197156IPR018097
DomainEGF_CA

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

9.16e-1199156PS01187
DomainASX_HYDROXYL

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

9.74e-11100156PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

1.39e-10106156IPR000152
DomainEGF_3

MEGF8 LRP4 SSPOP LRP1B THBD SVEP1 NOTCH2

2.70e-10235157PS50026
DomainEGF_CA

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

3.27e-10122156SM00179
DomainEGF-like_Ca-bd_dom

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

3.61e-10124156IPR001881
DomainEGF_1

MEGF8 LRP4 SSPOP LRP1B THBD SVEP1 NOTCH2

4.78e-10255157PS00022
DomainEGF_2

MEGF8 LRP4 SSPOP LRP1B THBD SVEP1 NOTCH2

6.25e-10265157PS01186
DomainEGF

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

1.69e-08235156SM00181
DomainEGF-like_dom

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

2.39e-08249156IPR000742
DomainLDLR_class-A_CS

LRP4 TMPRSS2 SSPOP LRP1B

2.42e-0840154IPR023415
DomainEGF-like_CS

MEGF8 LRP4 LRP1B THBD SVEP1 NOTCH2

3.17e-08261156IPR013032
DomainEGF

LRP4 LRP1B THBD SVEP1 NOTCH2

3.67e-08126155PF00008
Domain-

LRP4 TMPRSS2 SSPOP LRP1B

4.31e-08461544.10.400.10
DomainLDLRA_1

LRP4 TMPRSS2 SSPOP LRP1B

5.13e-0848154PS01209
DomainLDrepeatLR_classA_rpt

LRP4 TMPRSS2 SSPOP LRP1B

5.59e-0849154IPR002172
DomainLDLa

LRP4 TMPRSS2 SSPOP LRP1B

5.59e-0849154SM00192
DomainLDLRA_2

LRP4 TMPRSS2 SSPOP LRP1B

5.59e-0849154PS50068
DomaincEGF

LRP4 LRP1B THBD

1.08e-0626153IPR026823
DomaincEGF

LRP4 LRP1B THBD

1.08e-0626153PF12662
DomainLdl_recept_a

LRP4 SSPOP LRP1B

5.83e-0645153PF00057
DomainEphrin_rec_like

SVEP1 TG

3.30e-0511152PF07699
DomainLdl_recept_b

LRP4 LRP1B

5.45e-0514152PF00058
DomainLDLRB

LRP4 LRP1B

5.45e-0514152PS51120
DomainLY

LRP4 LRP1B

6.28e-0515152SM00135
DomainLDLR_classB_rpt

LRP4 LRP1B

6.28e-0515152IPR000033
DomainEphrin_rec_like

SVEP1 TG

1.79e-0425152SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

SVEP1 TG

1.79e-0425152IPR011641
DomainhEGF

SVEP1 NOTCH2

2.25e-0428152PF12661
Domain-

LRP4 LRP1B

4.39e-04391522.120.10.30
Domain6-blade_b-propeller_TolB-like

LRP4 LRP1B

6.11e-0446152IPR011042
DomainEGF_extracell

LRP1B SVEP1

1.04e-0360152IPR013111
DomainEGF_2

LRP1B SVEP1

1.04e-0360152PF07974
Domain-

SSPOP FURIN

1.53e-03731522.60.120.260
DomainGalactose-bd-like

SSPOP FURIN

2.52e-0394152IPR008979
PathwayPID_NOTCH_PATHWAY

SSPOP FURIN NOTCH2

1.12e-0559113M17
PathwayWP_SARSCOV2_AND_COVID19_PATHWAY

TMPRSS2 FURIN

2.48e-0510112M40050
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

TMPRSS2 FURIN

4.30e-0513112M46426
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

FURIN NOTCH2

8.41e-0518112M614
PathwayREACTOME_ATTACHMENT_AND_ENTRY

TMPRSS2 FURIN

9.40e-0519112M41729
PathwayWP_POSTCOVID_NEUROINFLAMMATION

TMPRSS2 FURIN

1.39e-0423112M48313
PathwayREACTOME_EARLY_SARS_COV_2_INFECTION_EVENTS

TMPRSS2 FURIN

3.63e-0437112M45028
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SSPOP NOTCH2

1.23e-0368112M27303
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

TMPRSS2 FURIN

1.30e-0370112M46438
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

FURIN NOTCH2

1.78e-0382112MM15922
Pubmed

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

TMPRSS2 FURIN

1.74e-0721529325052
Pubmed

Regulation of Stress Responses and Translational Control by Coronavirus.

TMPRSS2 FURIN

1.74e-07215227384577
Pubmed

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.

TMPRSS2 FURIN

1.74e-07215232703818
Pubmed

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.

TMPRSS2 FURIN

1.74e-07215235343766
Pubmed

Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2.

TMPRSS2 FURIN

5.21e-07315234356057
Pubmed

ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.

TMPRSS2 FURIN

5.21e-07315232691890
Pubmed

Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.

TMPRSS2 FURIN

5.21e-07315233243086
Pubmed

Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation.

EZH2 TMPRSS2

5.21e-07315222930729
Pubmed

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2.

TMPRSS2 FURIN

5.21e-07315232329629
Pubmed

Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma.

TMPRSS2 FURIN

5.21e-07315234726347
Pubmed

Evaluation of various endothelial biomarkers in ankylosing spondylitis.

THBD SVEP1

5.21e-07315221556780
Pubmed

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction.

TMPRSS2 FURIN

5.21e-07315234807954
Pubmed

COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

TMPRSS2 FURIN

1.04e-06415232867305
Pubmed

Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway.

EZH2 NOTCH2

1.04e-06415228923203
Pubmed

Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans.

TMPRSS2 FURIN

1.04e-06415235038715
Pubmed

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

LRP4 LRP1B

1.73e-06515220383322
Pubmed

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.

EZH2 TMPRSS2

1.73e-06515234230470
Pubmed

Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2.

TMPRSS2 FURIN

2.60e-06615236071039
Pubmed

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.

EZH2 TMPRSS2

3.64e-06715227728805
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

MEGF8 LRP4

6.24e-0691529693030
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MEGF8 LRP4 LRP1B KLF16 FURIN NOTCH2

6.41e-06120115635696571
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP4 LRP1B

9.53e-061115224639464
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1B FURIN

1.58e-051415215082773
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP4 LRP1B

3.63e-052115221337463
InteractionADAMTS1 interactions

LRP4 TMPRSS2 FURIN NOTCH2

4.47e-0795144int:ADAMTS1
InteractionNTN5 interactions

LRP4 LRP1B NOTCH2

5.36e-0724143int:NTN5
InteractionZSCAN21 interactions

LRP4 LRP1B KLF16 NOTCH2

1.48e-06128144int:ZSCAN21
InteractionHSP90B1 interactions

EZH2 TMPRSS2 LRP1B KLF16 FURIN TG

2.65e-06650146int:HSP90B1
InteractionZFP41 interactions

LRP4 LRP1B NOTCH2

7.64e-0657143int:ZFP41
InteractionCRISPLD1 interactions

EZH2 NOTCH2

9.39e-067142int:CRISPLD1
InteractionIGFL3 interactions

LRP4 LRP1B NOTCH2

1.75e-0575143int:IGFL3
InteractionZNF563 interactions

LRP4 LRP1B

2.95e-0512142int:ZNF563
InteractionZNF146 interactions

EZH2 KLF16 NOTCH2

3.13e-0591143int:ZNF146
InteractionPFKP interactions

EZH2 TMPRSS2 KLF16 FURIN

3.46e-05284144int:PFKP
InteractionRNASE4 interactions

LRP1B NOTCH2

4.06e-0514142int:RNASE4
InteractionIGSF5 interactions

LRP4 NOTCH2

4.06e-0514142int:IGSF5
InteractionTG interactions

EZH2 TG

4.06e-0514142int:TG
InteractionDEFB123 interactions

LRP4 LRP1B

5.35e-0516142int:DEFB123
InteractionLANCL1 interactions

TMPRSS2 LRP1B FURIN

5.82e-05112143int:LANCL1
InteractionSULF2 interactions

LRP4 LRP1B NOTCH2

6.97e-05119143int:SULF2
InteractionRPL10 interactions

EZH2 LRP4 LRP1B KLF16 NOTCH2

7.79e-05702145int:RPL10
InteractionZNF224 interactions

LRP4 LRP1B

8.45e-0520142int:ZNF224
InteractionATP2A2 interactions

EZH2 TMPRSS2 KLF16 NOTCH2

9.57e-05369144int:ATP2A2
InteractionPGRMC1 interactions

EZH2 TMPRSS2 KLF16 FURIN

1.02e-04375144int:PGRMC1
InteractionDDOST interactions

EZH2 TMPRSS2 KLF16 FURIN

1.02e-04375144int:DDOST
InteractionRAB6A interactions

EZH2 TMPRSS2 FURIN

1.15e-04141143int:RAB6A
InteractionZNF408 interactions

LRP4 LRP1B NOTCH2

1.25e-04145143int:ZNF408
InteractionSTAM2 interactions

EZH2 TMPRSS2 FURIN

1.30e-04147143int:STAM2
InteractionRPN1 interactions

EZH2 TMPRSS2 KLF16 FURIN NOTCH2

1.57e-04814145int:RPN1
InteractionFEZF1 interactions

LRP4 LRP1B

1.68e-0428142int:FEZF1
InteractionVDAC2 interactions

EZH2 TMPRSS2 KLF16 FURIN

1.76e-04432144int:VDAC2
InteractionCTSD interactions

EZH2 TMPRSS2 TG

1.90e-04167143int:CTSD
InteractionZNF107 interactions

KLF16 NOTCH2

2.06e-0431142int:ZNF107
InteractionIMMT interactions

EZH2 TMPRSS2 KLF16 FURIN

2.13e-04454144int:IMMT
InteractionRAB7A interactions

MEGF8 EZH2 KLF16 FURIN NOTCH2

2.33e-04886145int:RAB7A
InteractionARPC3 interactions

EZH2 TMPRSS2 FURIN

2.49e-04183143int:ARPC3
InteractionRAB10 interactions

EZH2 TMPRSS2 FURIN

2.78e-04190143int:RAB10
InteractionZNF724 interactions

KLF16 NOTCH2

2.79e-0436142int:ZNF724
InteractionPABPN1 interactions

EZH2 TMPRSS2 FURIN

2.87e-04192143int:PABPN1
InteractionBRICD5 interactions

TMPRSS2 FURIN NOTCH2

2.96e-04194143int:BRICD5
InteractionIGFBP4 interactions

MEGF8 NOTCH2

3.62e-0441142int:IGFBP4
InteractionSERPINA5 interactions

THBD FURIN

3.62e-0441142int:SERPINA5
InteractionDEK interactions

EZH2 TMPRSS2 FURIN

3.68e-04209143int:DEK
InteractionPFKL interactions

EZH2 TMPRSS2 FURIN

3.94e-04214143int:PFKL
InteractionZNF398 interactions

LRP4 NOTCH2

3.98e-0443142int:ZNF398
InteractionHSD17B12 interactions

TMPRSS2 KLF16 FURIN

4.27e-04220143int:HSD17B12
InteractionSEC61A1 interactions

EZH2 TMPRSS2 FURIN

4.45e-04223143int:SEC61A1
InteractionDYRK1A interactions

LRP4 LRP1B NOTCH2 SHROOM1

4.48e-04552144int:DYRK1A
InteractionZNF121 interactions

LRP4 NOTCH2

4.56e-0446142int:ZNF121
InteractionAIF1L interactions

TMPRSS2 FURIN

4.96e-0448142int:AIF1L
InteractionFOXD4L6 interactions

LRP1B NOTCH2

5.17e-0449142int:FOXD4L6
InteractionSEC31A interactions

EZH2 TMPRSS2 FURIN

5.25e-04236143int:SEC31A
InteractionLCOR interactions

EZH2 LRP4 LRP1B

5.64e-04242143int:LCOR
InteractionTMOD3 interactions

EZH2 TMPRSS2 FURIN

5.71e-04243143int:TMOD3
InteractionYTHDF3 interactions

TMPRSS2 KLF16 FURIN

5.92e-04246143int:YTHDF3
InteractionRRM2B interactions

TMPRSS2 FURIN

6.05e-0453142int:RRM2B
InteractionZNF518A interactions

EZH2 NOTCH2

6.28e-0454142int:ZNF518A
InteractionRAB1B interactions

EZH2 TMPRSS2 FURIN

6.42e-04253143int:RAB1B
InteractionPRKCSH interactions

EZH2 KLF16 NOTCH2

6.72e-04257143int:PRKCSH
InteractionMEGF8 interactions

MEGF8 TMPRSS2

6.75e-0456142int:MEGF8
InteractionTPM4 interactions

EZH2 TMPRSS2 FURIN

6.88e-04259143int:TPM4
InteractionSLC25A13 interactions

EZH2 TMPRSS2 FURIN

7.19e-04263143int:SLC25A13
InteractionLYPD1 interactions

MEGF8 NOTCH2

7.24e-0458142int:LYPD1
InteractionZSCAN26 interactions

LRP4 NOTCH2

7.50e-0459142int:ZSCAN26
InteractionANKRD36B interactions

LRP4 LRP1B

7.75e-0460142int:ANKRD36B
InteractionMYO1B interactions

EZH2 TMPRSS2 FURIN

8.01e-04273143int:MYO1B
InteractionCNBP interactions

EZH2 TMPRSS2 FURIN

8.27e-04276143int:CNBP
InteractionZNF397 interactions

EZH2 NOTCH2

8.27e-0462142int:ZNF397
InteractionGNAI2 interactions

EZH2 TMPRSS2 FURIN

8.36e-04277143int:GNAI2
InteractionZNF331 interactions

LRP4 LRP1B

8.54e-0463142int:ZNF331
InteractionPLAT interactions

LRP1B NOTCH2

8.54e-0463142int:PLAT
InteractionSLIT2 interactions

TMPRSS2 NOTCH2

8.54e-0463142int:SLIT2
InteractionFBN2 interactions

SVEP1 NOTCH2

9.09e-0465142int:FBN2
InteractionHLA-A interactions

EZH2 TMPRSS2 FURIN

9.45e-04289143int:HLA-A
InteractionSERPINH1 interactions

EZH2 TMPRSS2 FURIN

1.11e-03306143int:SERPINH1
InteractionRPL36AL interactions

LRP1B KLF16 NOTCH2

1.15e-03309143int:RPL36AL
InteractionYTHDF2 interactions

TMPRSS2 KLF16 FURIN

1.18e-03312143int:YTHDF2
InteractionHYOU1 interactions

EZH2 TMPRSS2 FURIN

1.23e-03317143int:HYOU1
InteractionKRT6C interactions

EZH2 FURIN

1.24e-0376142int:KRT6C
InteractionEGFL7 interactions

TMPRSS2 NOTCH2

1.27e-0377142int:EGFL7
InteractionZNF707 interactions

LRP4 NOTCH2

1.34e-0379142int:ZNF707
InteractionGPC4 interactions

EZH2 TMPRSS2

1.34e-0379142int:GPC4
InteractionEPC1 interactions

EZH2 KLF16

1.41e-0381142int:EPC1
InteractionZNF592 interactions

EZH2 NOTCH2

1.41e-0381142int:ZNF592
InteractionUBR4 interactions

EZH2 TMPRSS2 FURIN

1.43e-03334143int:UBR4
InteractionACTN1 interactions

EZH2 TMPRSS2 FURIN

1.52e-03341143int:ACTN1
InteractionCYBC1 interactions

TMPRSS2 THBD

1.58e-0386142int:CYBC1
InteractionMAZ interactions

EZH2 NOTCH2

1.58e-0386142int:MAZ
InteractionSPTB interactions

TMPRSS2 FURIN

1.62e-0387142int:SPTB
InteractionRPN2 interactions

EZH2 TMPRSS2 KLF16 FURIN

1.65e-03782144int:RPN2
InteractionDNAJB11 interactions

EZH2 TMPRSS2 FURIN

1.65e-03351143int:DNAJB11
InteractionTAF3 interactions

EZH2 KLF16

1.66e-0388142int:TAF3
InteractionTIMP3 interactions

LRP1B NOTCH2

1.73e-0390142int:TIMP3
CytobandEnsembl 112 genes in cytogenetic band chr7q36

EZH2 SSPOP

1.22e-03159152chr7q36
GeneFamilyLow density lipoprotein receptors

LRP4 LRP1B

2.14e-0513102634
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 FURIN NOTCH2

4.06e-071901543639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 FURIN NOTCH2

4.32e-07193154bc7e0b6b07be91901f02f1524fb81f3c538ab6b9
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 FURIN NOTCH2

4.50e-071951542c03d1a2f208b6737311458a4bd8f2e4444de29a
ToppCellfacs-Skin-Skin_Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 FURIN NOTCH2

4.50e-07195154ffd87cc7ae9b141bf48e072ea1a1420794499790
ToppCellfacs-Skin-Skin_Anagen-18m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 FURIN NOTCH2

4.50e-071951540d37dd66a8d60fc9cda3d6e3c4fbe67e577b890e
ToppCellControl-Classical_Monocyte-cMono_3|Control / Disease condition and Cell class

TMPRSS2 THBD FURIN

1.39e-051431539d1cee36e32aefb6af5c65b3281b31a45d5cd17e
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 KLF16 NOTCH2

2.46e-051731530f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VMO1 THBD FURIN

2.50e-05174153062e7bd9072ca7ee68e09b1da28af13f1bc60b44
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 SSPOP ADAP2

2.63e-0517715365709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 SSPOP ADAP2

2.63e-051771538684d47a547e2a06496f15e8da0200ecddc431e0
ToppCellnormal_Lymph_Node-Myeloid_cells-CD141+_DCs|normal_Lymph_Node / Location, Cell class and cell subclass

VMO1 THBD ADAP2

2.72e-05179153ec995ccd6e1dbd06287ad836c232d9aed1cf94a8
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-DC1|lymph-node_spleen / Manually curated celltypes from each tissue

VMO1 THBD ADAP2

2.91e-05183153c9e3d91f4c3395a73295b92e25608e0effb5d241
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

VMO1 THBD ADAP2

2.95e-051841538e393eea7240584a3cef718bee094e2705ec1891
ToppCellE18.5-samps-Mesenchymal|E18.5-samps / Age Group, Lineage, Cell class and subclass

LRP4 SVEP1 NOTCH2

3.20e-051891530c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP4 NOTCH2 ADAP2

3.25e-05190153979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP4 SVEP1 NOTCH2

3.30e-051911533379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP4 SVEP1 NOTCH2

3.30e-0519115314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 SVEP1 ADAP2

3.30e-05191153beb5bb42bd53bce01339da9110d374901548793c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP4 SVEP1 ADAP2

3.30e-051911536609d85fd2577633dcc067507304a6f9e5865ca3
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 SVEP1 ADAP2

3.40e-05193153abdfb8b1dbdcb424042e21017a9e829fced4457e
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 SVEP1 ADAP2

3.40e-05193153027e098ad018e782287f84eee0f77551018f2196
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 SVEP1 ADAP2

3.40e-05193153c5463a87f20b3a7f7ffda677b2f5a0e9e49d6685
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LRP4 SVEP1 NOTCH2

3.46e-051941534f9bd0ded0dde1df885850714f29e73e992539a5
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VMO1 THBD ADAP2

3.51e-05195153028622b234551b185977fbee10c06851a45456a5
ToppCell(6)_Macrophage|World / shred on Cell_type and subtype

VMO1 THBD ADAP2

3.62e-05197153010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VMO1 THBD ADAP2

3.62e-0519715367bf15ee83938bd40f6ecd5abaaf90ad95096d21
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VMO1 THBD ADAP2

3.67e-05198153ff9c97c6f579a4e79859d420f224556fadc1f6ab
ToppCell(04)_Interm._basal>secr.|World / shred by cell type by condition

TMPRSS2 VMO1 NOTCH2

3.73e-05199153ed399244433f781fc291a9bff16825b8a3ca294f
ToppCellCaecum-Dendritic_cell-cDC1|Caecum / Region, Cell class and subclass

VMO1 THBD ADAP2

3.73e-051991539ab38a0060a883de6fe3da8cdac42e124d7981d9
ToppCellCaecum-(5)_Dendritic_cell-(51)_cDC1|Caecum / shred on region, Cell_type, and subtype

VMO1 THBD ADAP2

3.73e-051991532b97fda45241b2ce7be904cf081cabcf3eb5ba1d
ToppCellTransverse-Macrophage-Macrophage|Transverse / Region, Cell class and subclass

VMO1 THBD ADAP2

3.79e-0520015317548806ba38008050244151d1216c69ef8a8310
ToppCellTransverse-(6)_Macrophage|Transverse / shred on region, Cell_type, and subtype

VMO1 THBD ADAP2

3.79e-05200153b28350de555fa756d2631f004f71d5ac69b1affe
ToppCellmLN-(6)_Macrophage-(61)_LYVE1_Macrophage|mLN / shred on region, Cell_type, and subtype

VMO1 THBD ADAP2

3.79e-05200153a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCellTransverse-(6)_Macrophage-(60)_Macrophage|Transverse / shred on region, Cell_type, and subtype

VMO1 THBD ADAP2

3.79e-052001532be675684a2958ea609939bb45248bede78a26bc
ToppCellmLN-Macrophage-LYVE1_Macrophage|mLN / Region, Cell class and subclass

VMO1 THBD ADAP2

3.79e-0520015389cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCellTransverse-Macrophage|Transverse / Region, Cell class and subclass

VMO1 THBD ADAP2

3.79e-052001531920605e5811938814d02b971069a4506868db5f
ToppCell(60)_Macrophage|World / shred on Cell_type and subtype

VMO1 THBD ADAP2

4.01e-0520415306d0cb306f1ad0014d81f8228868938e48c2bcf3
ToppCell(61)_LYVE1_Macrophage|World / shred on Cell_type and subtype

VMO1 THBD ADAP2

4.13e-05206153711e961a9a03bfd2f0958bd14f25f7f207a2f2b5
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)|Hippocampus / BrainAtlas - Mouse McCarroll V32

VMO1 ADAP2

4.18e-049115278e2e65beb15bf1e251974c72fbcfab817492772
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

VMO1 ADAP2

4.18e-0491152f59908093416ca7b3ca27019d71c79acbdea18cb
ToppCellHippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

VMO1 ADAP2

4.18e-0491152104d2ab9fe5cc404388c32fafb34e421c2e138be
ToppCellLPS_only-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

6.31e-041121529801227fe5a6f5ae1b6c5a9e7fa7f35c4c52efe1
ToppCellBAL-Control-cDC_7|Control / Compartment, Disease Groups and Clusters

KLF16 THBD

7.36e-04121152b49b044a687a31883dfccecf10a183b5ba567f7a
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBD SVEP1

7.36e-04121152e82c9e10b98c8d7ad828cf8ac19a2342014be2ba
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

THBD NOTCH2

7.60e-0412315264a2d7e40d9c948a9ccaf61c465fb2207e0b7ab8
ToppCellPND01-03-samps-Lymphocyte-B_cell-B_cell_1|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SSPOP TG

8.23e-041281525d82247ceda55017628720ed8b6c36ff7cec8437
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

8.23e-04128152cfc73cb803ba50a4a8709e19e70e1e399118c849
ToppCellPND01-03-samps-Lymphocyte-B_cell|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SSPOP TG

8.23e-041281527661402dd7cd533c1bfe8d9247cecd88c1be9a5e
ToppCellPND01-03-samps-Lymphocyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SSPOP TG

8.23e-04128152d3158825a2178244b57ac5ad2676617fd58d8466
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VMO1 ADAP2

8.62e-04131152aaf87b85fa5886808407ea91721058aaad3472a6
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_macrophage|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VMO1 ADAP2

8.62e-04131152384952292627316db18b522066a29ebbc3a6723b
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-mDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

8.75e-04132152f8e2ba53063007d7507f1837ad669b0e4333cd23
ToppCellRV-14._Fibroblast_III|World / Chamber and Cluster_Paper

KLF16 SVEP1

9.01e-041341528c4046ba1f85172915a112499e492c3efe8474c2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP LRP1B

9.55e-04138152c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SVEP1 ADAP2

1.01e-03142152f4e4cde228149d5a536fbf0517ed71d81e296faf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSPOP THBD

1.03e-03143152d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SSPOP THBD

1.03e-031431528900b92a24289204b9ec7baccc11594fec7694f1
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

1.07e-03146152b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCellControl-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

TMPRSS2 THBD

1.07e-03146152fcd8548b42275758d7d77ad2651afe7ad0e5ea2a
ToppCellE16.5-samps-Myeloid-Macrophage-CD163+_Macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAP2 TG

1.10e-0314815256e146980a71b5ca655118ae13310c5949220d4a
ToppCellE16.5-samps-Myeloid-Macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAP2 TG

1.10e-03148152cd5f697d8c2f272be1f3f52a05446749278431c5
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3|E16.5-samps / Age Group, Lineage, Cell class and subclass

SVEP1 NOTCH2

1.11e-03149152651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP LRP1B

1.13e-03150152afd651c654e715414eff64cf3a37378d057a56a2
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MEGF8 SSPOP

1.17e-03153152e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TMPRSS2 ADAP2

1.19e-03154152ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCellBasal_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

LRP4 LRP1B

1.20e-0315515230accc72a6a914ae0c4d52b373ea1c9a98efbf22
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

LRP1B ADAP2

1.22e-031561529a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EZH2 NOTCH2

1.23e-03157152eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

LRP4 THBD

1.23e-03157152b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

VMO1 THBD

1.23e-0315715219c0599a669803c4db1f174de1ce755e562a50a3
ToppCell368C-Myeloid-Dendritic-cDC1|368C / Donor, Lineage, Cell class and subclass (all cells)

VMO1 ADAP2

1.25e-03158152c276a259e20ee704e2d04baf693e8d677f96f654
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

KLF16 NOTCH2

1.26e-03159152b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

THBD TG

1.26e-03159152fb9a45c1d596226128ce4f1adaebb066766e590a
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B SVEP1

1.28e-03160152c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

THBD FURIN

1.28e-031601526ed37d1fd0304932319d6b942502404115ff36a7
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B SVEP1

1.28e-0316015225c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-DC1|bone_marrow / Manually curated celltypes from each tissue

VMO1 THBD

1.30e-031611522f068ee643de2f647c289779a6624265ab9a749b
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

MEGF8 NOTCH2

1.31e-03162152810881210e015c788814e4fe8d7a24c929cf2621
ToppCellControl-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

NOTCH2 ADAP2

1.31e-03162152aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MEGF8 SHROOM1

1.33e-031631528f24cef152f5965727bbeee116bd26c75cbba82a
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMPRSS2 TG

1.34e-031641526ea188e17895961cd112152fb111d08641cc5e45
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 ADAP2

1.36e-03165152622aca1d49bd8c917b131e4f4959d9dba411d22b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

THBD FURIN

1.38e-03166152ce570b768988e30898cf0387c2aa99989631f13f
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|367C / Donor, Lineage, Cell class and subclass (all cells)

THBD ADAP2

1.38e-03166152430d604f5bef9fae20dc81492e6695616f6701a3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

THBD FURIN

1.39e-031671521cd9e2af85c6c5b9e1d88991c87ac6980b387243
ToppCelldroplet-Lung-LUNG-1m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EZH2 SSPOP

1.39e-03167152e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

EZH2 TG

1.39e-03167152315cde87eed2b42a1b9b068fae94caa10ec64c70
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP4 ADAP2

1.39e-031671523c06894fc6177f3c204094719904da42f08b9af8
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-mDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

1.41e-031681522dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SVEP1 NOTCH2

1.41e-031681529930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH2 SHROOM1

1.41e-03168152100ab6d36592b61f4db9f8cb90c48afac016d679
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

VMO1 THBD

1.43e-03169152a0681317867e31319210a23e56660a53f4529efe
ToppCellfacs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SSPOP TG

1.43e-03169152b798b91567d2f49082e2d8a337169f241c8d2080
ToppCelldroplet-Thymus-nan-18m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEGF8 ADAP2

1.43e-031691524ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCellmyeloid-Monocyte-CD14+_Monocyte|Monocyte / Lineage, cell class and subclass

THBD FURIN

1.43e-031691527c3144a6599787f28662f5b22b8e45f4a115aeda
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SVEP1 FURIN

1.43e-0316915201a24a8817628125bd004b2be68ffa62c7111f6e
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Monocytes|normal_Pleural_Fluid / Location, Cell class and cell subclass

THBD SHROOM1

1.43e-031691527b71463f0fd802b422c8d394a435901009ca200f
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KLF16 THBD

1.44e-03170152fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|390C / Donor, Lineage, Cell class and subclass (all cells)

THBD ADAP2

1.44e-03170152439167e44a1bd5ac8e1e457351dd202ec968db46
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VMO1 ADAP2

1.44e-031701523cbeea6bfa500928c413b1c6129f6dedc769cd1e
DrugOrphenadrine hydrochloride [341-69-5]; Down 200; 13uM; PC3; HT_HG-U133A

MEGF8 THBD SVEP1 ADAP2

6.89e-061971543801_DN
DrugCitalopram hydrobromide [59729-32-7]; Up 200; 1uM; PC3; HT_HG-U133A

TMPRSS2 SVEP1 FURIN ADAP2

6.89e-061971544555_UP
DrugK0-24

THBD TG

1.13e-058152CID000066137
Drugdihydrolipoamide

EZH2 NOTCH2 TG

6.05e-05119153CID000000663
Drugsimvastatin

LRP4 LRP1B THBD FURIN

9.96e-05390154CID000054454
Drugezetimibe

LRP4 LRP1B FURIN

1.13e-04147153CID000150311
Drug25-hydroxycholesterol

LRP4 LRP1B NOTCH2

1.46e-04160153CID000065094
DrugAC1L3UFA

FURIN TG

1.52e-0428152CID000122350
Drugmonatepil

LRP4 LRP1B

1.63e-0429152CID000060810
Drugguanidinoethylmercaptosuccinic acid

THBD FURIN

2.38e-0435152CID000003464
DrugNadolol [42200-33-9]; Up 200; 13uM; PC3; HT_HG-U133A

LRP4 THBD SVEP1

2.57e-041941534021_UP
DrugTadjakonine [11087-94-8]; Up 200; 7.4uM; PC3; HT_HG-U133A

TMPRSS2 NOTCH2 ADAP2

2.57e-041941534599_UP
DrugDelcorine; Down 200; 8.4uM; PC3; HT_HG-U133A

SVEP1 FURIN ADAP2

2.57e-041941534275_DN
DrugIvermectin [70288-86-7]; Down 200; 4.6uM; MCF7; HT_HG-U133A

TMPRSS2 NOTCH2 ADAP2

2.57e-041941532213_DN
DrugEtifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

SVEP1 ADAP2 TG

2.57e-041941534117_UP
DrugClofilium tosylate [92953-10-1]; Down 200; 7.8uM; PC3; HT_HG-U133A

MEGF8 LRP4 SVEP1

2.57e-041941534492_DN
DrugChicago sky blue 6B [2610-05-1]; Up 200; 4uM; MCF7; HT_HG-U133A

TMPRSS2 SVEP1 FURIN

2.61e-041951534971_UP
DrugTestosterone propionate [57-85-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A

MEGF8 LRP4 TG

2.61e-041951535636_UP
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

MEGF8 THBD ADAP2

2.61e-041951533670_DN
Drug(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; PC3; HT_HG-U133A

THBD SVEP1 TG

2.61e-041951534016_UP
DrugCephalexin monohydrate [23325-78-2]; Down 200; 11uM; MCF7; HT_HG-U133A

TMPRSS2 THBD ADAP2

2.65e-041961535615_DN
DrugAmiprilose hydrochloride [60414-06-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A

LRP4 ADAP2 TG

2.65e-041961534119_UP
DrugMethyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; MCF7; HT_HG-U133A

TMPRSS2 NOTCH2 ADAP2

2.65e-041961537360_DN
DrugBezafibrate [41859-67-0]; Up 200; 11uM; MCF7; HT_HG-U133A

TMPRSS2 SVEP1 ADAP2

2.69e-041971532630_UP
DrugCarteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

LRP4 SVEP1 FURIN

2.69e-041971534096_DN
Drugvaldecoxib; Down 200; 10uM; PC3; HT_HG-U133A

TMPRSS2 THBD SVEP1

2.69e-041971536408_DN
DrugApramycin [37321-09-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

TMPRSS2 SVEP1 FURIN

2.69e-041971534959_UP
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

LRP4 TMPRSS2 ADAP2

2.73e-041981534126_UP
DrugIfosfamide [3778-73-2]; Up 200; 15.4uM; PC3; HT_HG-U133A

THBD SVEP1 ADAP2

2.73e-041981535805_UP
DrugPralidoxime chloride [51-15-0]; Down 200; 23.2uM; MCF7; HT_HG-U133A

THBD NOTCH2 ADAP2

2.73e-041981535383_DN
DrugRiluzole hydrochloride; Down 200; 14.8uM; PC3; HT_HG-U133A

MEGF8 THBD ADAP2

2.73e-041981533666_DN
DrugChlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A

TMPRSS2 THBD FURIN

2.73e-041981535391_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A

TMPRSS2 THBD SVEP1

2.77e-041991534383_DN
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; MCF7; HT_HG-U133A

TMPRSS2 SVEP1 ADAP2

2.77e-041991535436_UP
DrugPyrazinamide [ 98-96-4]; Up 200; 32.4uM; MCF7; HT_HG-U133A

SVEP1 FURIN ADAP2

2.77e-041991534962_UP
DrugPerphenazine [58-39-9]; Down 200; 10uM; MCF7; HT_HG-U133A

TMPRSS2 FURIN ADAP2

2.77e-041991535698_DN
DrugNimodipine [66085-59-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A

TMPRSS2 FURIN NOTCH2

2.77e-041991535421_DN
DrugPirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; PC3; HT_HG-U133A

LRP4 TMPRSS2 ADAP2

2.77e-041991535872_UP
DrugClenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

MEGF8 TMPRSS2 THBD

2.77e-041991533228_UP
DrugDihydroergotoxine mesylate [8067-24-1]; Down 200; 6.4uM; PC3; HT_HG-U133A

THBD SVEP1 FURIN

2.77e-041991534071_DN
DrugPHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A

LRP4 THBD ADAP2

2.77e-041991534330_UP
DrugGPGR

FURIN TG

2.81e-0438152CID000485268
DrugFlorfenicol [73231-34-2]; Up 200; 11.2uM; PC3; HT_HG-U133A

LRP4 NOTCH2 ADAP2

2.81e-042001536701_UP
DrugAC1L9KZ2

FURIN TG

4.49e-0448152CID000447561
DiseaseSolid Neoplasm

EZH2 NOTCH2

5.06e-067152C0280100
DiseaseLymphoma

EZH2 NOTCH2

1.86e-0440152C0024299
DiseaseDiffuse Large B-Cell Lymphoma

EZH2 NOTCH2

3.53e-0455152C0079744
Diseasestomach cancer (is_implicated_in)

EZH2 LRP1B

6.04e-0472152DOID:10534 (is_implicated_in)
Diseaselung cancer (is_implicated_in)

EZH2 LRP1B

6.38e-0474152DOID:1324 (is_implicated_in)
DiseasePolydactyly

MEGF8 LRP4

1.58e-03117152C0152427
Diseasecolorectal cancer (is_implicated_in)

EZH2 LRP1B

1.69e-03121152DOID:9256 (is_implicated_in)
DiseasePapillary Renal Cell Carcinoma

LRP1B VMO1

1.89e-03128152C1306837
DiseaseRenal Cell Carcinoma

LRP1B VMO1

1.89e-03128152C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

LRP1B VMO1

1.89e-03128152C1266043
DiseaseChromophobe Renal Cell Carcinoma

LRP1B VMO1

1.89e-03128152C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

LRP1B VMO1

1.89e-03128152C1266044
DiseaseTakayasu arteritis

LRP1B SVEP1

2.51e-03148152EFO_1001857
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

LRP1B VMO1

2.51e-03148152C0279702

Protein segments in the cluster

PeptideGeneStartEntry
GNAHCADCGAADPDW

ADAP2

21

Q9NPF8
EACNSHACQWDGGDC

NOTCH2

1441

Q04721
HTGERPFACDWQGCD

KLF16

151

Q9BXK1
GRCIPGHWACDGDND

LRP1B

1016

Q9NZR2
GHWACDGDNDCGDFS

LRP1B

1021

Q9NZR2
DPDLCLTCGAADHWD

EZH2

581

Q15910
PGFCDECQDWTWGEH

MEGF8

1176

Q7Z7M0
FWAGNCSEAACGAAD

MEGF8

1986

Q7Z7M0
WASGNGGREHDSCNC

FURIN

291

P09958
GAWDCSVENGGCEHA

THBD

241

P07204
VPHGWLCDNQDDCGD

SSPOP

1391

A2VEC9
LHECPGTAGADDCWQ

SHROOM1

441

Q2M3G4
DFGDWSDHCPKGACG

VMO1

161

Q7Z5L0
CEADGQWSSGFPHCE

SVEP1

3046

Q4LDE5
NWCDGVSHCPGGEDE

TMPRSS2

131

O15393
CDAFGSWEPVQCHAG

TG

1031

P01266
PAQWQCDGDNDCGDH

LRP4

46

O75096
LWHCDGDNDCGDNSD

LRP4

126

O75096