Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessL-histidine import across plasma membrane

SLC7A1 SLC38A3

1.84e-052892GO:1903810
GeneOntologyCellularComponentstereocilia ankle link

VEZT ADGRV1

2.78e-046912GO:0002141
GeneOntologyCellularComponentstereocilia ankle link complex

VEZT ADGRV1

2.78e-046912GO:0002142
GeneOntologyCellularComponentstereocilium membrane

VEZT ADGRV1

2.78e-046912GO:0060171
GeneOntologyCellularComponentstereocilia coupling link

VEZT ADGRV1

5.16e-048912GO:0002139
DomainSCAN

ZNF449 ZSCAN32 ZSCAN21 SCAND2P ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

2.78e-15569211SM00431
DomainSCAN_BOX

ZNF449 ZSCAN32 ZSCAN21 SCAND2P ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

4.21e-15589211PS50804
DomainSCAN

ZNF449 ZSCAN32 ZSCAN21 SCAND2P ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

4.21e-15589211PF02023
DomainSCAN_dom

ZNF449 ZSCAN32 ZSCAN21 SCAND2P ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

4.21e-15589211IPR003309
DomainRetrov_capsid_C

ZNF449 ADAMTS10 ZSCAN32 ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

5.16e-15599211IPR008916
DomainDUF2476

PRR23A PRR23B PRR23D1

4.61e-074923PF10630
DomainPRR23

PRR23A PRR23B PRR23D1

4.61e-074923IPR018903
DomainARM-type_fold

NCAPD3 MYBBP1A INTS1 LTN1 IPO13 PKP2 TTI1 PDS5A TRIP12 TNPO3 ITPR1

8.68e-073399211IPR016024
DomainARM-like

NCAPD3 LTN1 IPO13 PKP2 TTI1 PDS5A TRIP12 TNPO3

5.61e-05270928IPR011989
Domain-

NCAPD3 IPO13 PKP2 TTI1 PDS5A TRIP12 TNPO3

1.13e-042229271.25.10.10
DomainCAT3

SLC7A1 SLC7A14

2.38e-045922IPR015606
DomainAA_permease_C

SLC7A1 SLC7A14

2.38e-045922PF13906
DomainCAT_C

SLC7A1 SLC7A14

2.38e-045922IPR029485
DomainXpo1

IPO13 TNPO3

3.55e-046922PF08389
DomainExportin-1/Importin-b-like

IPO13 TNPO3

3.55e-046922IPR013598
DomainCalx_beta

FREM2 ADGRV1

6.59e-048922SM00237
DomainCalx_beta

FREM2 ADGRV1

8.45e-049922IPR003644
DomainCalx-beta

FREM2 ADGRV1

8.45e-049922PF03160
DomainFilamin

TRIM2 MYCBP2

1.28e-0311922PF00630
DomainFILAMIN_REPEAT

TRIM2 MYCBP2

1.28e-0311922PS50194
DomainFilamin/ABP280_rpt

TRIM2 MYCBP2

1.28e-0311922IPR001298
DomainFilamin/ABP280_repeat-like

TRIM2 MYCBP2

1.28e-0311922IPR017868
DomainZINC_FINGER_C2H2_2

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

1.47e-037759211PS50157
DomainZINC_FINGER_C2H2_1

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

1.50e-037779211PS00028
DomainAA_permease_2

SLC7A1 SLC7A14

1.81e-0313922PF13520
DomainAA/rel_permease1

SLC7A1 SLC7A14

1.81e-0313922IPR002293
DomainZnf_C2H2-like

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

1.82e-037969211IPR015880
DomainZnf_C2H2

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

1.99e-038059211IPR007087
DomainZnF_C2H2

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

2.05e-038089211SM00355
Domainzf-C2H2

ZNF449 ZSCAN32 ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

2.16e-036939210PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF449 ZSCAN32 ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

2.18e-036949210IPR013087
DomainZnf_RING-CH

MARCHF6 LTN1

3.11e-0317922IPR011016
DomainRINGv

MARCHF6 LTN1

3.11e-0317922SM00744
Domainzf-C3HC4

TRIM2 MARCHF6 VPS8 LTN1 UBR3

4.92e-03223925PF00097
DomainHEAT_REPEAT

NCAPD3 IPO13 PDS5A

4.99e-0370923PS50077
DomainAA-permease/SLC12A_dom

SLC7A1 SLC7A14

5.20e-0322922IPR004841
DomainAA_permease

SLC7A1 SLC7A14

5.20e-0322922PF00324
DomainQuino_amine_DH_bsu

TRIM2 VPS8

5.20e-0322922IPR011044
DomainZnf_RING

TRIM2 MYCBP2 MARCHF6 VPS8 LTN1 UBR3

5.48e-03326926IPR001841
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MYBBP1A WIZ MYCBP2 VEZT TPTE2 LRRC1 LTN1 MCAM UBR3 TTI1 BIRC6 CTDSP2 PPP1CB ITPR1

7.66e-071049931427880917
Pubmed

Defining the membrane proteome of NK cells.

SLC7A1 NCAPD3 MYBBP1A ATP8A1 MYCBP2 MARCHF6 INTS1 MARF1 MMGT1 PIGG OGA BIRC6 ILVBL ITPR1

2.69e-061168931419946888
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

MYBBP1A PGAP1 ZKSCAN8 MCAM TMC4 ECT2 BIRC6 ITPR1

6.14e-0636393814691545
Pubmed

Human mutations in integrator complex subunits link transcriptome integrity to brain development.

INTS1 INTS8

7.07e-06293228542170
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

MYBBP1A VCAN INTS1 TTI1 CTNNA2 TRIP12 TNPO3 ILVBL NXF1

7.81e-0649893936634849
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

SLC7A1 MYBBP1A ARHGAP12 LTN1 IPO13 TTI1 PDS5A BIRC6 TNPO3 ILVBL

1.07e-05657931036180527
Pubmed

A strategy for cloning the hereditary hemochromatosis gene.

ZKSCAN8 CTDSP2

2.12e-0539328673473
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

NCAPD3 MYCBP2 LTN1 PDS5A PALS2 TRIP12

2.34e-0521293633853758
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

MYBBP1A WIZ MYCBP2 VCAN INTS1 ZKSCAN8 PDS5A MED23 INTS8 TRIP12 NXF1 PPP1CB

3.18e-051082931238697112
Pubmed

Tagging genes with cassette-exchange sites.

MARCHF6 ZMYM1 MED23 ECT2 TRIP12 BIRC6 PPP1CB

3.37e-0533593715741177
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ORC1 NCAPD3 MYBBP1A WIZ ZSCAN21 INTS1 ZKSCAN8 PDS5A FANCM TRIP12 ILVBL NXF1 PPP1CB

4.04e-051294931330804502
Pubmed

Streamlined analysis schema for high-throughput identification of endogenous protein complexes.

INTS1 MED23 INTS8 PPP1CB

4.06e-057193420133760
Pubmed

The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps.

MCAM IPO13

4.23e-05493221804459
Pubmed

A protein interaction landscape of breast cancer.

FANCC MYBBP1A BPIFB1 PDS5A TMTC2 ZMYM1 CTNNA2 TNPO3 PPP1CB

5.18e-0563493934591612
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

LTN1 UBR3 PDS5A FANCM BIRC6 ZKSCAN5 SLC7A14 SLITRK1

5.47e-0549393815368895
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FREM2 NCAPD3 PARG MARF1 ECT2 PCDHGC3 ILVBL NXF1 ITPR1

6.27e-0565093938777146
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NCAPD3 MYCBP2 PGAP1 MARCHF6 LTN1 MCAM MMGT1 IPO13 TTI1 TMTC2 PIGG ITPR1

8.62e-051201931235696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SLC7A1 NCAPD3 MYBBP1A INTS1 ZKSCAN8 MCAM PDS5A ZMYM1 MED23 INTS8 TNPO3 ILVBL

8.76e-051203931229180619
Pubmed

The DNA sequence and analysis of human chromosome 13.

FREM2 SLC7A1 MYCBP2 TPTE2 SLITRK1

9.66e-0517093515057823
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

MYCBP2 LTN1 UBR3 TRIP12

1.27e-049593429643511
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

LTN1 IPO13 TTI1 TNPO3 SOS2

1.36e-0418393523956138
Pubmed

Evidence for subcomplexes in the Fanconi anemia pathway.

FANCC FANCM

1.47e-04793216720839
Pubmed

Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.

MYCBP2 LTN1

1.47e-04793236700049
Pubmed

The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

FANCC FANCM

1.47e-04793224451376
Pubmed

Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.

FKBP6 CAMK4 MSH4

1.70e-044093320378615
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ORC1 NCAPD3 WIZ INTS1 LTN1 PDS5A CTNNA2 PIGG MED23 ECT2 INTS8 ILVBL NXF1

1.74e-041497931331527615
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

NCAPD3 INTS1 LTN1 ITPR1

1.80e-0410493431240132
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

MYBBP1A MYCBP2 PKP2 MED23 TRIP12 NXF1 ITPR1

1.84e-0444093734244565
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

MYBBP1A ZSCAN21 MMGT1 TMTC2 ADGRV1 PALS2 MED23 SLC38A3 PPP1CB

1.84e-0475093911230166
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC7A1 ATP8A1 SLC4A3 SLC38A3

1.86e-0410593430280653
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

NCAPD3 MYBBP1A MYCBP2 ZKSCAN8 MED23 ECT2 TRIP12 BIRC6 NXF1

2.01e-0475993935915203
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

SLC7A1 NCAPD3 MYBBP1A VEZT PDS5A OGA INTS8 TRIP12 TNPO3 ILVBL

2.15e-04942931031073040
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

NCAPD3 MYBBP1A MYCBP2 TPTE2 PIGG

2.16e-0420293524639526
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

NCAPD3 MYCBP2 SZT2 MMGT1 TTI1 PDS5A ILVBL PPP1CB

2.25e-0460693836538041
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SLC7A1 ATP8A1 VEZT MCAM MMGT1 PIGG PALS2 BIRC6 SLC38A3 ILVBL

2.34e-04952931038569033
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

MYBBP1A WIZ CAMK4 MCAM PKP2 PDS5A TRIP12 BIRC6 CTDSP2

2.39e-0477793935844135
Pubmed

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.

FANCC FANCM

2.52e-04993217396147
Pubmed

The zinc finger-associated SCAN box is a conserved oligomerization domain.

SCAND2P ZKSCAN8

2.52e-04993210567577
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

FANCC ORC1 MYBBP1A ECD BPIFB1 PDS5A ZMYM1 ECT2 NXF1 PPP1CB ITPR1

2.62e-041155931120360068
Pubmed

Modularized functions of the Fanconi anemia core complex.

FANCC FANCM

3.14e-041093224910428
Pubmed

A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice.

PRR23A PRR23B

3.14e-041093224565867
Pubmed

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.

PGAP1 ADGRV1

3.14e-041093217329413
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

NCAPD3 MYBBP1A WIZ INTS1 PDS5A INTS8

3.17e-0434193632971831
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYBBP1A MYCBP2 INTS1 PDS5A TRIP12 BIRC6 NXF1 PPP1CB

3.71e-0465393822586326
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

ADAMTS10 FREM2 MYCBP2 RANGRF VCAN LTN1 MARF1 NBPF11 PRR23D2 CTDSP2 ITPR1

4.02e-041215931115146197
Pubmed

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

INTS1 MED23 INTS8

4.16e-045493316239144
Pubmed

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

FANCC FANCM

4.59e-041293216116422
Pubmed

Identification of epilepsy genes in human and mouse.

ADGRV1 ITPR1

4.59e-041293211700294
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

MYCBP2 ECD INTS1 LTN1 NXF1

4.94e-0424293534011540
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

NCAPD3 VEZT ECD LRRC1 TRIP12 BIRC6 TNPO3 ILVBL

5.14e-0468693828380382
Pubmed

Phosphoproteomic analysis of the developing mouse brain.

MYBBP1A ARHGAP12 CTNNA2 OGA TNPO3

5.32e-0424693515345747
Pubmed

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.

ECT2 TRIP12

5.41e-041393232929379
Pubmed

The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.

FANCC FANCM

5.41e-041393224699063
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

NCAPD3 VEZT INTS1 LTN1 IPO13 TTI1 PDS5A CTNNA2 INTS8 PCDHGC3

5.48e-041061931033845483
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NCAPD3 SZT2 MARCHF6 IPO13 ADGRV1 MED23 OGA

5.56e-0452993714621295
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

NCAPD3 MYBBP1A LTN1 PDS5A TRIP12 BIRC6 NXF1 PPP1CB

6.09e-0470493829955894
Pubmed

Structure of the catalytic core of the Integrator complex.

INTS1 INTS8

6.30e-041493233548203
Pubmed

The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.

INTS1 INTS8

6.30e-041493232697989
Pubmed

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.

INTS1 INTS8

6.30e-041493232647223
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

MYBBP1A WIZ INTS1 PDS5A TRIP12 PPP1CB

6.77e-0439493627248496
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

NCAPD3 INTS1 PKP2 TRIP12

7.21e-0415093430154076
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

FANCC FANCM

7.26e-041593219536649
Pubmed

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

FANCC FANCM

7.26e-041593217289582
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

ADAMTS10 VCAN

7.26e-041593238871984
Pubmed

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.

ATP8A1 PGAP1

7.26e-041593225338677
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ORC1 SLC7A1 WIZ MYCBP2 SZT2 INTS1 PIGG BIRC6 TNPO3 CTDSP2

7.49e-041105931035748872
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

ECD LRRC1 LTN1 PKP2 PDS5A MED23 TNPO3

7.76e-0456093735241646
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FREM2 WIZ INTS1 PDS5A ECT2 TRIP12 BIRC6 NXF1

8.12e-0473693829676528
Pubmed

Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

FANCC FANCM

8.28e-041693220301753
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

VEZT ADGRV1

8.28e-041693217567809
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

FANCC FANCM

8.28e-041693227760317
Pubmed

A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

FANCC FANCM

8.28e-041693220347428
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

WIZ CAMK4 BPIFB1 MED23 OGA ILVBL NXF1 ITPR1

9.48e-0475493835906200
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

MYCBP2 LTN1 IPO13 PKP2 TTI1 ZMYM1 PIGG TNPO3

9.48e-0475493833060197
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

MYBBP1A WIZ LRRC1 INTS1 ECT2 INTS8 TRIP12

9.71e-0458293720467437
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ORC1 MYBBP1A MYCBP2 LTN1 PKP2 PDS5A ECT2 TRIP12 BIRC6 NXF1 PPP1CB

9.75e-041353931129467282
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

CTNNA2 ITPR1

1.05e-031893233323119
Pubmed

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.

FANCC FANCM

1.05e-031893222343915
Pubmed

Functional proteomics mapping of a human signaling pathway.

MYCBP2 VPS8 MCAM PKP2 TRIP12 TNPO3 PPP1CB

1.06e-0359193715231748
Pubmed

Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.

MYBBP1A PDS5A PPP1CB

1.09e-037593329459360
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCAPD3 MYBBP1A MYCBP2 NAF1 PARG OGA TRIP12 PPP1CB

1.12e-0377493815302935
Pubmed

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

FANCC FANCM

1.30e-032093222705371
Pubmed

Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.

ZNF449 MYBBP1A ZSCAN21 ZKSCAN8 FANCM

1.39e-0330593521244100
Pubmed

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

MYBBP1A MYCBP2

1.44e-032193224923560
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

TMPRSS6 FAM180A PGAP1 INTS1 BPIFB1 SLITRK1

1.50e-0346093620562862
Pubmed

Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.

ADAMTS10 CPA2 ADGRV1

1.51e-038493315203218
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

NCAPD3 ECD VPS8 LTN1 IPO13 PDS5A CTNNA2 PIGG TNPO3 ILVBL ITPR1

1.60e-031440931130833792
Pubmed

Fanconi Anemia

FANCC FANCM

1.73e-032393220301575
Pubmed

Brugada Syndrome

RANGRF PKP2

1.88e-032493220301690
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

NCAPD3 MYBBP1A MYCBP2 INTS1 OGA ECT2 BIRC6 ILVBL NXF1 PPP1CB

1.96e-031257931037317656
Pubmed

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.

MCHR1 PGAP1

2.04e-032593228706241
Pubmed

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.

INTS1 INTS8

2.04e-032593234004147
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

FANCC ORC1 CAMK4 PIGG

2.04e-0319993436688959
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ZNF449 SLC7A1 MYCBP2 VEZT TMPRSS6 LRRC1 ADGRV1 PALS2 INTS8 PPP1CB SOS2

2.09e-031489931128611215
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

NCAPD3 MYBBP1A LTN1 TRIP12

2.16e-0320293433005030
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

NCAPD3 ZSCAN21 TPTE2 FANCM OGA ECT2 ILVBL

2.16e-0367093722990118
Pubmed

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

ADGRV1 TRIP12 ITPR1

2.41e-039993319730683
Pubmed

Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.

SLC7A1 MYCBP2 ILVBL PPP1CB

2.44e-0320993426389662
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ZSCAN32 MYBBP1A ZSCAN21 ECD ZNF397 KDM5D ZNF232 ZKSCAN5

2.45e-0387793820211142
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SLC7A1 MYBBP1A ZSCAN21 VCAN PGAP1 LTN1 ZMYM1 TRIP12 ITPR1

2.49e-03108493911544199
InteractionZSCAN32 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 UBR3 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 NXF1

3.64e-1345909int:ZSCAN32
InteractionZNF232 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZMYM1 ZNF232 ZSCAN23 ZKSCAN5

7.38e-1152908int:ZNF232
InteractionZSCAN20 interactions

ZNF449 ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23 ZKSCAN5

4.72e-1065908int:ZSCAN20
InteractionSCAND1 interactions

ZNF449 ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23 ZNF287

8.67e-1070908int:SCAND1
InteractionZSCAN30 interactions

ZSCAN32 ZSCAN21 ZNF397 ZNF232 ZSCAN23

4.60e-0915905int:ZSCAN30
InteractionSCAND3 interactions

ZSCAN32 ZSCAN21 ZNF397 ZNF232 ZSCAN23

6.67e-0916905int:SCAND3
InteractionZNF174 interactions

ORC1 ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23

1.96e-0867907int:ZNF174
InteractionGPR17 interactions

VEZT VPS8 INTS1 LTN1 IPO13 UBR3 TTI1 PDS5A PIGG MED23 TNPO3

5.37e-082839011int:GPR17
InteractionZSCAN21 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

1.06e-07128908int:ZSCAN21
InteractionZSCAN29 interactions

ZSCAN32 ZNF397 ZNF232 ZSCAN23 NXF1

1.19e-0727905int:ZSCAN29
InteractionZKSCAN8 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZMYM1 ZNF232 ECT2 ZSCAN23

1.20e-07130908int:ZKSCAN8
InteractionZKSCAN3 interactions

ZSCAN32 ZKSCAN8 ZNF397 ZNF232 ZSCAN23

1.44e-0728905int:ZKSCAN3
InteractionPGBD1 interactions

ZSCAN32 MYCBP2 ZKSCAN8 ZNF397 ZNF232

1.73e-0729905int:PGBD1
InteractionZNF213 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232

1.73e-0729905int:ZNF213
InteractionZSCAN22 interactions

ZNF449 ZSCAN32 ZSCAN21 ZNF397 ZSCAN23

3.99e-0734905int:ZSCAN22
InteractionZKSCAN1 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23

4.91e-0766906int:ZKSCAN1
InteractionZSCAN23 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF232 ZSCAN23

8.11e-0739905int:ZSCAN23
InteractionC3orf18 interactions

NCAPD3 VPS8 INTS1 LTN1 TTI1 PDS5A TNPO3

8.28e-07115907int:C3orf18
InteractionGPR45 interactions

SLC7A1 NCAPD3 LRRC1 VPS8 INTS1 IPO13 TTI1 PDS5A PIGG TNPO3

9.20e-073009010int:GPR45
InteractionZKSCAN4 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23

1.05e-0675906int:ZKSCAN4
InteractionZNF446 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23

2.71e-0688906int:ZNF446
InteractionZNF396 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397

3.09e-0623904int:ZNF396
InteractionOPALIN interactions

NCAPD3 INTS1 LTN1 IPO13 PDS5A PIGG INTS8 TNPO3

4.38e-06209908int:OPALIN
InteractionGPR182 interactions

SLC7A1 NCAPD3 INTS1 LTN1 IPO13 TTI1 PDS5A PIGG MED23 INTS8 TNPO3

5.76e-064559011int:GPR182
InteractionZNF397 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232

8.41e-0662905int:ZNF397
InteractionSIGLECL1 interactions

VPS8 LTN1 IPO13 TTI1 PDS5A TNPO3

1.15e-05113906int:SIGLECL1
InteractionZNF24 interactions

ZSCAN32 ZSCAN21 ZKSCAN8 ZNF397 ZNF232 ZSCAN23 ZNF287

1.30e-05174907int:ZNF24
InteractionSCRIB interactions

ZNF449 MYCBP2 LRRC1 ZKSCAN8 MCAM ECT2 NXF1 PPP1CB

2.52e-05266908int:SCRIB
InteractionCOMTD1 interactions

NCAPD3 LRRC1 VPS8 INTS1 TTI1 PDS5A TNPO3

3.18e-05200907int:COMTD1
InteractionXAGE1A interactions

FREM2 ZMYM1 ADGRV1 PCDHGC3

3.32e-0541904int:XAGE1A
InteractionNPTN interactions

INTS1 LTN1 MCAM IPO13 TTI1 PDS5A INTS8 TNPO3

3.46e-05278908int:NPTN
InteractionHCST interactions

VPS8 INTS1 LTN1 IPO13 PDS5A INTS8 TNPO3

3.72e-05205907int:HCST
InteractionCTDP1 interactions

NCAPD3 INTS1 LTN1 MED23 ECT2 INTS8 ITPR1

3.96e-05207907int:CTDP1
InteractionC19orf38 interactions

NCAPD3 VPS8 LTN1 PDS5A TNPO3

4.16e-0586905int:C19orf38
InteractionZKSCAN5 interactions

ZSCAN21 ZNF232 ZKSCAN5

4.62e-0516903int:ZKSCAN5
InteractionFPR1 interactions

VPS8 INTS1 IPO13 TTI1 PDS5A TNPO3

5.11e-05147906int:FPR1
InteractionZKSCAN7 interactions

ZSCAN32 ZSCAN21 ZSCAN23

7.92e-0519903int:ZKSCAN7
InteractionZNF197 interactions

ZSCAN32 ZNF397 ZNF232

9.29e-0520903int:ZNF197
InteractionCD70 interactions

SLC7A1 INTS1 TTI1 PDS5A PIGG TNPO3

1.00e-04166906int:CD70
InteractionUNC93B1 interactions

NCAPD3 VPS8 LTN1 IPO13 PDS5A PIGG TNPO3 ILVBL NXF1

1.03e-04417909int:UNC93B1
InteractionPROKR1 interactions

INTS1 IPO13 TTI1

1.08e-0421903int:PROKR1
InteractionZNF444 interactions

ZSCAN32 LRRC1 ZKSCAN8 ZNF397 ZNF232

1.13e-04106905int:ZNF444
InteractionP2RY10 interactions

INTS1 LTN1 IPO13 TTI1 TNPO3

1.13e-04106905int:P2RY10
InteractionZNF496 interactions

ZSCAN21 ZKSCAN8 ZNF397 ZNF232

1.14e-0456904int:ZNF496
InteractionZNF445 interactions

ZKSCAN8 ZNF232 ZSCAN23 ZNF287

1.23e-0457904int:ZNF445
InteractionB3GNT8 interactions

INTS1 PDS5A TNPO3

1.25e-0422903int:B3GNT8
InteractionINTS6 interactions

INTS1 INTS8 NXF1 CTDSP2 PPP1CB

1.34e-04110905int:INTS6
InteractionCACNG4 interactions

NCAPD3 LRRC1 PKP2 TTI1

1.40e-0459904int:CACNG4
InteractionZNF483 interactions

ZSCAN21 ZKSCAN8 ZNF397 ZNF232

1.40e-0459904int:ZNF483
InteractionFAXC interactions

NCAPD3 MYCBP2 VPS8 ECT2 TNPO3

1.87e-04118905int:FAXC
InteractionFZD10 interactions

VEZT VPS8 INTS1 TNPO3

2.17e-0466904int:FZD10
InteractionGPR55 interactions

SLC7A1 INTS1 IPO13 TTI1

2.30e-0467904int:GPR55
InteractionVIPR2 interactions

VEZT VPS8 INTS1 PDS5A PIGG TNPO3

2.34e-04194906int:VIPR2
InteractionCYB5B interactions

VPS8 INTS1 MCAM MMGT1 PDS5A TNPO3 NXF1

2.89e-04285907int:CYB5B
InteractionINSL4 interactions

UBR3 ADGRV1

2.92e-046902int:INSL4
InteractionSKA1 interactions

MYCBP2 INTS1 ZMYM1 ILVBL

3.03e-0472904int:SKA1
InteractionRBM5 interactions

MARF1 MMGT1 PKP2 PDS5A NXF1

3.49e-04135905int:RBM5
InteractionTMED4 interactions

MYBBP1A MMGT1 SLC7A14 NXF1

3.92e-0477904int:TMED4
InteractionPCDHGB1 interactions

FREM2 PKP2 TMTC2 PCDHGC3

3.92e-0477904int:PCDHGB1
InteractionMGARP interactions

SLC7A1 INTS1 IPO13 TTI1 PIGG INTS8

4.81e-04222906int:MGARP
InteractionSIRT6 interactions

MYBBP1A WIZ MYCBP2 PKP2 PDS5A MED23 TRIP12 PCDHGC3 NXF1 ITPR1

4.89e-046289010int:SIRT6
InteractionADGRE2 interactions

MARCHF6 MMGT1 SLC7A14

5.08e-0435903int:ADGRE2
InteractionTMPRSS4 interactions

VEZT TMPRSS6 LTN1 MMGT1 TTI1 PCDHGC3 ITPR1

5.16e-04314907int:TMPRSS4
InteractionMFSD4A interactions

SLC7A1 INTS1 IPO13 TTI1 PDS5A TNPO3

5.17e-04225906int:MFSD4A
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF449 ZSCAN32 WIZ ZSCAN21 ZKSCAN8 ZKSCAN2 ZNF397 ZNF232 ZSCAN23 ZKSCAN5 ZNF287

3.91e-05718641128
GeneFamilyIntegrator complex

INTS1 INTS8

1.26e-03156421366
GeneFamilyArmadillo repeat containing|Importins

IPO13 TNPO3

1.82e-0318642596
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCC FANCM

2.25e-0320642548
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

SLC7A1 TRIM2 MYCBP2 ARHGAP12 PARG MARCHF6 MARF1 PDS5A PALS2 TRIP12

5.09e-064669110M13522
Drug0317956-0000 [391210-11-0]; Down 200; 10uM; PC3; HT_HG-U133A

ZSCAN32 VEZT CAMK4 VCAN CTDSP2 ITPR1 SOS2

1.20e-051949073774_DN
DrugChlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; HL60; HG-U133A

TMPRSS6 MCAM FAXDC2 CPA2 OGA ZKSCAN5 TNPO3

1.24e-051959071371_DN
DrugChlorzoxazone [95-25-0]; Up 200; 23.6uM; MCF7; HT_HG-U133A

SLC7A1 GPR20 MARCHF6 CPA2 CTNNA2 OGA SOS2

1.29e-051969072263_UP
DrugCefadroxil [50370-12-2]; Down 200; 11uM; PC3; HT_HG-U133A

SLC7A1 WIZ VCAN ZNF232 SLC4A3 ITPR1 SOS2

1.37e-051989074080_DN
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; HL60; HT_HG-U133A

ATP8A1 VEZT MARCHF6 ZKSCAN8 MCAM CTNNA2 ILVBL

1.42e-051999072187_UP
Diseaseanxiety, stress-related disorder, major depressive disorder

ZKSCAN8 ZKSCAN2 ZSCAN23

3.31e-0446863EFO_0005230, EFO_0010098, MONDO_0002009
Diseasemotor function measurement

CAMK4 LRRC1

4.54e-0411862EFO_0010749
Diseasehepcidin:transferrin saturation ratio

TMPRSS6 SLITRK1

8.60e-0415862EFO_0007902
DiseaseBone marrow hypocellularity

FANCC FANCM

1.25e-0318862C1855710
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

PPP1CB SOS2

1.39e-0319862C3501846
DiseaseCostello syndrome (disorder)

PPP1CB SOS2

1.39e-0319862C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

PPP1CB SOS2

1.39e-0319862C1843181
DiseaseCardio-facio-cutaneous syndrome

PPP1CB SOS2

1.39e-0319862C1275081
DiseaseLEOPARD Syndrome

PPP1CB SOS2

1.87e-0322862C0175704
DiseaseBrugada Syndrome (disorder)

RANGRF PKP2

2.22e-0324862C1142166
DiseaseNoonan Syndrome

PPP1CB SOS2

2.22e-0324862C0028326
DiseaseFanconi Anemia

FANCC FANCM

2.41e-0325862C0015625
DiseasePancytopenia

FANCC FANCM

2.61e-0326862C0030312
DiseaseAcute monocytic leukemia

FANCC FANCM

2.61e-0326862C0023465

Protein segments in the cluster

PeptideGeneStartEntry
LNEAVLLESVLEVPV

SLC4A3

536

P48751
LLVDQPFTLEILTSL

BIRC6

1011

Q9NR09
VPISLSIDRLEFDLL

BPIFB1

221

Q8TDL5
LTITESTILEILPEL

VCAN

2556

P13611
TVLEFLLPLLVISVF

GPR20

201

Q99678
QTLLLEVLADDVPEI

ADGRV1

2301

Q8WXG9
LTILADNIPELSEVV

ADGRV1

3721

Q8WXG9
ITSILDALDIFLLPV

CPA2

206

P48052
ILTLLQTIPFDIEDL

ECD

386

O95905
FNNLIPISLLVTLEV

ATP8A1

351

Q9Y2Q0
ILVTRLILLTEDQPT

ADAMTS10

286

Q9H324
VTQELLDSILINLIP

PDS5A

201

Q29RF7
LATIIQLFQVPLEEE

ECT2

471

Q9H8V3
VIQIFIEDNLTLSLP

INTS8

341

Q75QN2
IEDIVIELIIQLPSN

LTN1

1641

O94822
PVTDQSLIVELLELQ

RANGRF

41

Q9HD47
LSLTVFLLVIVELIP

CHRNA1

271

P02708
TIDILLLLLVLEETS

MGAM2

21

Q2M2H8
VVVSSLLLQEEEPLA

INTS1

1581

Q8N201
IDIITALILNDINPL

ITPR1

2071

Q14643
EIFETPTEISLVLEL

CAMK4

106

Q16566
PLVSQFLISDELLLD

FANCM

1171

Q8IYD8
LPLVLEVEVVFTQLE

FREM2

166

Q5SZK8
DTPQLTLTELRVLLE

KDM5D

831

Q9BY66
TLRIIEENIPELLSL

NXF1

256

Q9UBU9
INPELIISRLFTEVL

PARG

761

Q86W56
LTEVLLPIVKTEFQL

MED23

1231

Q9ULK4
PVSELSLELLLLQVV

MARCHF6

521

O60337
VTLELVVENPLELFS

PCDHGC3

106

Q9UN70
LFLAILLAIEEPVIS

DEFB119

6

Q8N690
LTELVLTENQLLTLP

LRRC1

291

Q9BTT6
NIILSSPEQLELFLL

MYBBP1A

206

Q9BQG0
QIVELILLELSSIFG

ARHGAP12

831

Q8IWW6
SREIFLSQPILLELE

PPP1CB

41

P62140
PQETTVLLVDELDLL

ORC1

611

Q13415
LIPPNTTVLFEIELL

FKBP6

126

O75344
NLELVNEILEDITPL

PALS2

56

Q9NZW5
FLLELAIFTLIEEVL

FAXDC2

171

Q96IV6
LQLVEETLPDNSILV

ILVBL

451

A1L0T0
SFLETNVPLLVLIEA

CTNNA2

391

P26232
ADTELLNLIPIFEEL

CTDSP2

241

O14595
ITLTDVDPLVEALLI

FANCC

191

Q00597
LLELFEAIPDTLQVL

MARF1

1306

Q9Y4F3
VPDIFIINLSVVDLL

MCHR1

146

Q99705
LLAELEISPDLQISI

FAM180A

61

Q6UWF9
LPIDIVLQTLLAFAV

MMGT1

41

Q8N4V1
LLELLTVLPEEFQTS

IPO13

166

O94829
LSLEEVILILAPETV

PRR23D1

91

E9PI22
VILILAPETVLQLTL

PRR23D1

96

E9PI22
IADELFTLVLPINIA

NPBWR1

81

P48145
ILFLELVNLTTLTPD

MCAM

511

P43121
LLQSEQELEVLSVLP

SZT2

51

Q5T011
EELLQEIDITPFLLA

SZT2

1331

Q5T011
SELPLVIQTFLNLEE

SLC38A3

166

Q99624
QELLSLLIERFEIPE

SOS2

636

Q07890
TLILIPEVLLSSVDE

PRR23A

96

A6NEV1
VLQDSLDVIQLLPVV

NBPF11

781

Q86T75
EPVTLEDLQLLADLF

OGA

551

O60502
TLILIPEVLLSSVDE

PRR23B

96

Q6ZRT6
PEVLESLFQLLLEIT

MYCBP2

246

O75592
LRSNILEPLVDIETI

MSH4

351

O15457
VLLLPELDAVILTCQ

PGAP1

661

Q75T13
LLQISPCITEQFIEL

VPS8

1021

Q8N3P4
ELTVSPINILQELLA

WIZ

801

O95785
LSLEEVILILAPETV

PRR23D2

91

P0DMB1
VILILAPETVLQLTL

PRR23D2

96

P0DMB1
EEPTALDILLITIQD

ANKFN1

581

Q8N957
FTLDVVLALLELPER

NCAPD3

411

P42695
LLISTLVFVILQQPE

SLC7A14

606

Q8TBB6
ELLVLEQFLTILPQE

ZSCAN21

86

Q9Y5A6
LLVLEQFLTILPGEV

ZNF287

91

Q9HBT7
VLEQFLTILPEEIQT

ZSCAN32

81

Q9NX65
LEVLILNDNLISTLP

SLITRK1

156

Q96PX8
AENPDIFAVIIILIL

SLC7A1

161

P30825
DLLTVLAVALLIQFP

TMC4

491

Q7Z404
ENIVVLSLSLLIIPF

TMTC2

391

Q8N394
ELLVLEQFPTVLLQE

SCAND2P

86

Q9GZW5
DVTSLPFLLEILTVL

TNPO3

136

Q9Y5L0
VLQLLEPQISFLEDL

UBR3

241

Q6ZT12
ELLVLEQFLSILPEE

ZNF397

91

Q8NF99
ELLVIEQFLTILPEK

ZKSCAN2

86

Q63HK3
VLEQFLTILPEELQS

ZNF232

96

Q9UNY5
VLEQFLTILPEELQS

ZBED9

96

Q6R2W3
NILDTAIIVIPLLVD

TPTE2

141

Q6XPS3
LLSVIDSLPEIIETL

ZMYM1

816

Q5SVZ6
QEDVELIELLDPSIL

VEZT

106

Q9HBM0
LPEIDSALQFISEII

TRIM2

176

Q9C040
VVLEVLTLLLLSVPQ

PIGG

441

Q5H8A4
NITFEDPSLDVILLL

TRIP12

1461

Q14669
TEALLTLTENIIIPF

PKP2

521

Q99959
ELLVLEQFLTILPTE

ZNF449

71

Q6P9G9
ELLVLEQFLTILPEE

ZKSCAN5

91

Q9Y2L8
LEQFLTILPEELQTL

ZKSCAN8

96

Q15776
LSPEVVQALLVEELL

TMPRSS6

166

Q8IU80
LPLVADVVQDVLATL

TTI1

731

O43156
LVLEQFLTILPEELQ

ZSCAN23

91

Q3MJ62
TLLVQLPERTVLLDA

NLRP12

686

P59046
ELLLNELPSVEELTI

NAF1

176

Q96HR8