Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2

1.58e-063152GO:0005220
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2

4.77e-0514152GO:0070679
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2

8.00e-0518152GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR2

2.42e-0431152GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2

2.74e-0433152GO:0005217
GeneOntologyMolecularFunctionalcohol binding

ITPR1 ITPR2

2.60e-03102152GO:0043178
GeneOntologyMolecularFunctioncalcium channel activity

ITPR1 ITPR2

4.12e-03129152GO:0005262
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ITPR1 ITPR2

4.83e-03140152GO:0099094
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

ITPR1 ITPR2

5.59e-03151152GO:0015085
GeneOntologyMolecularFunctiontransmembrane transporter binding

ITPR1 ITPR2

7.20e-03172152GO:0044325
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ITPR1 ITPR2

8.98e-03193152GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

ITPR1 ITPR2

9.34e-03197152GO:0022834
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2

1.73e-059152GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2

2.63e-0511152GO:0031094
GeneOntologyCellularComponentsarcoplasmic reticulum

ITPR1 ITPR2

1.78e-0388152GO:0016529
GeneOntologyCellularComponentsarcoplasm

ITPR1 ITPR2

2.96e-03114152GO:0016528
HumanPhenoNasogastric tube feeding in infancy

DYRK1A TRMU CTCF

1.21e-053773HP:0011470
DomainInsP3_rcpt-bd

ITPR1 ITPR2

1.56e-063142IPR000493
DomainRIH_assoc

ITPR1 ITPR2

7.81e-066142PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2

7.81e-066142IPR013662
DomainIns145_P3_rec

ITPR1 ITPR2

7.81e-066142PF08709
DomainRYDR_ITPR

ITPR1 ITPR2

7.81e-066142PF01365
DomainRIH_dom

ITPR1 ITPR2

7.81e-066142IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2

7.81e-066142IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2

7.81e-066142IPR015925
Domain-

ITPR1 ITPR2

7.81e-0661421.25.10.30
DomainMIR

ITPR1 ITPR2

2.34e-0510142PS50919
DomainMIR

ITPR1 ITPR2

2.34e-0510142PF02815
DomainMIR

ITPR1 ITPR2

2.34e-0510142SM00472
DomainMIR_motif

ITPR1 ITPR2

2.34e-0510142IPR016093
DomainARM-type_fold

DOCK2 ITPR1 ITPR2

1.86e-03339143IPR016024
DomainIon_trans_dom

ITPR1 ITPR2

3.20e-03114142IPR005821
DomainIon_trans

ITPR1 ITPR2

3.20e-03114142PF00520
Domain-

ZNF599 CTCF PLAGL2

1.29e-026791433.30.160.60
Domainzf-C2H2

ZNF599 CTCF PLAGL2

1.36e-02693143PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF599 CTCF PLAGL2

1.37e-02694143IPR013087
DomainZINC_FINGER_C2H2_2

ZNF599 CTCF PLAGL2

1.84e-02775143PS50157
DomainZINC_FINGER_C2H2_1

ZNF599 CTCF PLAGL2

1.85e-02777143PS00028
DomainZnf_C2H2-like

ZNF599 CTCF PLAGL2

1.97e-02796143IPR015880
DomainZnf_C2H2

ZNF599 CTCF PLAGL2

2.03e-02805143IPR007087
DomainZnF_C2H2

ZNF599 CTCF PLAGL2

2.05e-02808143SM00355
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2

4.52e-065102M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

6.78e-066102M47960
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

1.63e-059102M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

2.03e-0510102M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

2.48e-0511102M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2

2.48e-0511102M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.52e-0513102M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2

3.52e-0513102M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

3.52e-0513102M47696
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

3.52e-0513102MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2

5.41e-0516102M26945
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

7.70e-0519102M47760
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2

7.70e-0519102M27423
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

7.70e-0519102M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

8.55e-0520102M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

9.44e-0521102M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.04e-0422102M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.04e-0422102M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2

1.14e-0423102M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2

1.35e-0425102MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2

1.57e-0427102M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2

1.57e-0427102MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2

1.70e-0428102M924
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2

2.22e-0432102MM14983
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2

2.82e-0436102M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR2

2.82e-0436102M39831
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR1 ITPR2

3.66e-0441102M512
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2

3.84e-0442102M791
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR1 ITPR2

4.22e-0444102M39845
PathwaySIG_CHEMOTAXIS

ITPR1 ITPR2

4.41e-0445102M5193
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR1 ITPR2

4.61e-0446102M8626
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

5.45e-0450102M47951
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2

6.12e-0453102MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2

6.35e-0454102MM15202
PathwayREACTOME_ION_HOMEOSTASIS

ITPR1 ITPR2

6.35e-0454102M27460
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR1 ITPR2

6.35e-0454102M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2

6.59e-0455102M47952
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2

8.11e-0461102MM15071
PathwayREACTOME_CA2_PATHWAY

ITPR1 ITPR2

8.37e-0462102M27321
PathwayKEGG_LONG_TERM_POTENTIATION

ITPR1 ITPR2

1.07e-0370102M3115
PathwayKEGG_LONG_TERM_DEPRESSION

ITPR1 ITPR2

1.07e-0370102M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2

1.13e-0372102MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

ITPR1 ITPR2

1.19e-0374102M48080
PathwayWP_ALZHEIMERS_DISEASE

ITPR1 ITPR2

1.19e-0374102MM15962
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

ITPR1 ITPR2

1.26e-0376102M9052
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2

1.26e-0376102MM15051
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR1 ITPR2

1.32e-0378102M1921
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

ITPR1 ITPR2

1.46e-0382102M27110
PathwayREACTOME_PLATELET_HOMEOSTASIS

ITPR1 ITPR2

1.60e-0386102M916
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR1 ITPR2

1.60e-0386102M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

ITPR1 ITPR2

1.60e-0386102M27206
PathwayKEGG_GAP_JUNCTION

ITPR1 ITPR2

1.75e-0390102M4013
PathwayREACTOME_OPIOID_SIGNALLING

ITPR1 ITPR2

1.75e-0390102M6467
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

ITPR1 ITPR2

1.95e-0395102M29842
PathwayREACTOME_CLEC7A_DECTIN_1_SIGNALING

ITPR1 ITPR2

2.16e-03100102M27467
PathwayKEGG_GNRH_SIGNALING_PATHWAY

ITPR1 ITPR2

2.20e-03101102M1979
PathwayREACTOME_CARDIAC_CONDUCTION

ITPR1 ITPR2

2.29e-03103102MM15196
PathwayREACTOME_SIGNALING_BY_VEGF

ITPR1 ITPR2

2.42e-03106102M27077
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ITPR1 ITPR2

2.51e-03108102M17034
PathwayKEGG_OOCYTE_MEIOSIS

ITPR1 ITPR2

2.75e-03113102M16817
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ITPR1 ITPR2

2.84e-03115102M9387
PathwayREACTOME_CARDIAC_CONDUCTION

ITPR1 ITPR2

3.62e-03130102M27454
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

ITPR1 ITPR2

3.67e-03131102MM15717
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

ITPR1 ITPR2

3.84e-03134102M29840
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

ITPR1 ITPR2

4.18e-03140102M27484
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

ITPR1 ITPR2

4.36e-03143102M27107
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

ITPR1 ITPR2

4.54e-03146102M27288
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ITPR1 ITPR2

4.60e-03147102MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

ITPR1 ITPR2

4.85e-03151102M39329
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

ITPR1 ITPR2

5.04e-03154102MM15974
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

ITPR1 ITPR2

5.17e-03156102M39475
PathwayREACTOME_MUSCLE_CONTRACTION

ITPR1 ITPR2

5.76e-03165102MM15026
PathwayKEGG_ALZHEIMERS_DISEASE

ITPR1 ITPR2

5.83e-03166102M16024
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

ITPR1 ITPR2

5.83e-03166102M608
PathwayREACTOME_HEMOSTASIS

DOCK2 ITPR1 ITPR2

6.41e-03571103MM14472
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

ITPR1 ITPR2

6.67e-03178102M2890
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

ITPR1 ITPR2

7.27e-03186102M27175
PathwayREACTOME_MUSCLE_CONTRACTION

ITPR1 ITPR2

8.61e-03203102M5485
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

ITPR1 ITPR2

9.19e-03210102MM15043
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

ITPR1 ITPR2

9.78e-03217102M18437
PathwayREACTOME_LEISHMANIA_INFECTION

ITPR1 ITPR2

9.96e-03219102M29836
PathwayREACTOME_HEMOSTASIS

DOCK2 ITPR1 ITPR2

1.04e-02679103M8395
Pubmed

Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.

ITPR1 ITPR2

1.98e-07216219120126
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

1.98e-07216218708078
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

1.98e-07216215201137
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

1.98e-07216223582047
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2

5.95e-07316231979185
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2

5.95e-07316217890015
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2

5.95e-07316210874040
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2

5.95e-07316218547250
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2

5.95e-0731629808793
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2

5.95e-07316224904548
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2

5.95e-07316236350267
Pubmed

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.

ITPR1 ITPR2

5.95e-07316232320395
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2

5.95e-07316227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2

5.95e-07316211413485
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2

5.95e-07316223983250
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2

5.95e-07316220395455
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

5.95e-07316217327232
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2

5.95e-0731629858485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

5.95e-07316226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2

5.95e-07316217581770
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2

5.95e-07316217437169
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

ITPR1 ITPR2

5.95e-07316223223241
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2

5.95e-07316220427533
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2

5.95e-07316218241669
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2

5.95e-07316216014380
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2

5.95e-07316218194433
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2

5.95e-0731621693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2

5.95e-07316219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2

5.95e-07316223955339
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2

1.19e-06416225215520
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2

1.19e-06416228419336
Pubmed

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

ITPR1 ITPR2

1.19e-06416221818117
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

ITPR1 ITPR2

1.19e-06416219120137
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2

1.19e-06416211163362
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2

1.19e-06416221424589
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2

1.19e-06416235494252
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2

1.19e-06416228615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2

1.19e-06416210828023
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2

1.98e-06516221568942
Pubmed

BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.

ITPR1 ITPR2

1.98e-06516211782428
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR2

2.97e-06616216844763
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR2

2.97e-06616223463619
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR2

2.97e-06616220519450
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2

2.97e-06616221762810
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR2

2.97e-06616225966694
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2

4.16e-06716222495310
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR2

4.16e-06716211860456
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2

7.13e-06916225737585
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2

1.09e-051116227514653
Pubmed

Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.

ITPR1 ITPR2

1.09e-051116220824138
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR1 ITPR2

1.80e-051416234630045
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR1 ITPR2

2.08e-051516228578927
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

ITPR1 ITPR2

4.56e-052216211696558
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR1 ITPR2

5.44e-052416210843712
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

ITPR1 ITPR2

8.00e-052916232123907
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

JADE3 PLAGL2 KIFBP CECR2

8.33e-0552916414621295
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ITPR1 ITPR2

1.38e-043816230786075
InteractionBANK1 interactions

ITPR1 ITPR2

3.40e-0512152int:BANK1
InteractionIRAG1 interactions

ITPR1 ITPR2

4.68e-0514152int:IRAG1
InteractionTESPA1 interactions

ITPR1 ITPR2

6.17e-0516152int:TESPA1
InteractionTRPC4 interactions

ITPR1 ITPR2

1.30e-0423152int:TRPC4
InteractionRASEF interactions

ITPR1 ITPR2

1.54e-0425152int:RASEF
InteractionTRPC1 interactions

ITPR1 ITPR2

2.08e-0429152int:TRPC1
InteractionBBOX1 interactions

ITPR1 ITPR2

2.08e-0429152int:BBOX1
CytobandEnsembl 112 genes in cytogenetic band chr22q13

TRMU A4GALT

5.08e-03330152chr22q13
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2

8.26e-073102297
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF599 CTCF PLAGL2

6.07e-0371810328
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITPR1 ITPR2 LRRC9

3.12e-0517516377c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellCOVID-19-lung-B_cells|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 JADE3 ITPR1

3.23e-05177163f54691e5558091c1734ab15153a10bff15ed171e
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

DOCK2 JADE3 ITPR1

3.23e-05177163653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CECR2 ITPR1 ITPR2

3.80e-05187163b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A

DYRK1A PLAGL2 A4GALT ITPR2

6.89e-061971543836_UP
Drugxestospongin C

ITPR1 ITPR2

2.66e-0512152ctd:C511704
DiseaseBrain Hypoxia

ITPR1 ITPR2

2.41e-072152C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

2.41e-072152C0995195
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

2.41e-072152C1140716
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

2.41e-072152C0003132
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2

1.59e-0512152DOID:1441 (implicated_via_orthology)
Diseasebasophil measurement

DYRK1A KIFBP

4.20e-0460152EFO_0803539
Diseasediffuse plaque measurement

MMD2 CECR2 MMD2 ITPR2

4.70e-04758154EFO_0010699
DiseaseMicrocephaly

DYRK1A KIFBP

5.23e-0467152C0025958
DiseaseNeurodevelopmental Disorders

DYRK1A ITPR1

1.00e-0393152C1535926
Diseaseobesity (implicated_via_orthology)

ITPR1 ITPR2

5.21e-03215152DOID:9970 (implicated_via_orthology)
Diseaseeosinophil percentage of leukocytes

DYRK1A CTCF KIFBP

5.84e-03746153EFO_0007991

Protein segments in the cluster

PeptideGeneStartEntry
DYACRQERHMIMHKR

CTCF

501

P49711
LAFERRHEFMALCMR

A4GALT

221

Q9NPC4
RHEFMALCMRDFVDH

A4GALT

226

Q9NPC4
RHFMFRNHLCLVFEM

DYRK1A

226

Q13627
NLERCFHRAMMKHFP

CECR2

526

Q9BXF3
ASFCRLMLHMHVDRD

ITPR2

776

Q14571
ICRKMLHRHMLIFRL

LRRC9

1331

Q6ZRR7
LRMVEHCLHMFDRMV

MMD2

96

Q8IY49
YDLRASFCRLMLHMH

ITPR1

776

Q14643
LVRDKMMECHFRFRH

TRMU

321

O75648
MMECHFRFRHQMALV

TRMU

326

O75648
DMQRIHLRFMFRHRS

DOCK2

501

Q92608
HTRMRMFMHLRQDLE

JADE3

466

Q92613
FETDMERRCKMHKRR

KIFBP

436

Q96EK5
MYCDKMFHRKDHLRN

PLAGL2

101

Q9UPG8
CRYMADVIRHMRLHT

ZNF599

236

Q96NL3
FVKCADMKDRRMHHG

KLHL38

501

Q2WGJ6