Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmodification-dependent protein binding

ZCWPW2 BRDT KMT2A PHF8

6.96e-05206224GO:0140030
GeneOntologyMolecularFunctionhistone binding

ZCWPW2 BRDT KMT2A PHF8

1.84e-04265224GO:0042393
GeneOntologyMolecularFunctionprotein serine/threonine kinase binding

BACE1 CLTC

3.15e-0424222GO:0120283
GeneOntologyMolecularFunctionlysine-acetylated histone binding

BRDT KMT2A

4.95e-0430222GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

BRDT KMT2A

5.28e-0431222GO:0140033
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

PICALM CLTC

6.36e-0434222GO:0050750
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

PICALM CLTC

8.38e-0439222GO:0070325
GeneOntologyMolecularFunctionclathrin binding

PICALM CLTC

2.17e-0363222GO:0030276
GeneOntologyMolecularFunctionmethylated histone binding

ZCWPW2 PHF8

4.00e-0386222GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

ZCWPW2 PHF8

4.19e-0388222GO:0140034
GeneOntologyMolecularFunctionpeptide binding

BACE1 PICALM CLTC

4.92e-03318223GO:0042277
GeneOntologyMolecularFunctionamyloid-beta binding

BACE1 PICALM

5.58e-03102222GO:0001540
GeneOntologyBiologicalProcessnegative regulation of heterochromatin formation

KMT2A PHF8

1.62e-056222GO:0031452
GeneOntologyBiologicalProcessamyloid-beta clearance by transcytosis

PICALM CLTC

2.27e-057222GO:0150093
GeneOntologyBiologicalProcessnegative regulation of chromatin organization

KMT2A PHF8

2.27e-057222GO:1905268
GeneOntologyBiologicalProcessmulticellular organismal-level chemical homeostasis

FGF7 PICALM AKAP11

1.17e-0490223GO:0140962
GeneOntologyBiologicalProcesskeratinocyte migration

KRT2 FGF7

2.25e-0421222GO:0051546
GeneOntologyBiologicalProcessclathrin coat assembly

PICALM CLTC

2.71e-0423222GO:0048268
GeneOntologyBiologicalProcesstranscytosis

PICALM CLTC

2.96e-0424222GO:0045056
GeneOntologyBiologicalProcessregulation of heterochromatin formation

KMT2A PHF8

2.96e-0424222GO:0031445
GeneOntologyBiologicalProcessnegative regulation of protein localization to plasma membrane

PICALM CLTC

4.96e-0431222GO:1903077
GeneOntologyBiologicalProcessnegative regulation of protein localization to cell periphery

PICALM CLTC

5.62e-0433222GO:1904376
GeneOntologyBiologicalProcessregulation of chromatin organization

KMT2A PHF8

8.27e-0440222GO:1902275
GeneOntologyBiologicalProcessamyloid-beta clearance

PICALM CLTC

8.27e-0440222GO:0097242
GeneOntologyBiologicalProcessnegative regulation of protein localization to membrane

PICALM CLTC

8.68e-0441222GO:1905476
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

GPM6A PICALM PLCB4

1.40e-0543233GO:0098688
GeneOntologyCellularComponentpresynaptic endocytic zone membrane

PICALM CLTC

1.05e-0414232GO:0098835
GeneOntologyCellularComponentpresynaptic endocytic zone

PICALM CLTC

1.75e-0418232GO:0098833
GeneOntologyCellularComponentexcitatory synapse

GPM6A PICALM PLCB4

2.14e-04107233GO:0060076
GeneOntologyCellularComponentclathrin coat of coated pit

PICALM CLTC

2.40e-0421232GO:0030132
GeneOntologyCellularComponentclathrin coat

PICALM CLTC

1.72e-0356232GO:0030118
DomainBROMODOMAIN_2

BRDT KMT2A

1.16e-0341232PS50014
DomainBROMO

BRDT KMT2A

1.21e-0342232SM00297
DomainBromodomain

BRDT KMT2A

1.21e-0342232IPR001487
Domain-

BRDT KMT2A

1.21e-03422321.20.920.10
DomainZnF_C3H1

ZC3H7B MKRN4P

1.58e-0348232SM00356
Domainzf-CCCH

ZC3H7B MKRN4P

1.65e-0349232PF00642
DomainZnf_CCCH

ZC3H7B MKRN4P

2.30e-0358232IPR000571
DomainPHD

KMT2A PHF8

3.81e-0375232PF00628
DomainZnf_PHD-finger

KMT2A PHF8

4.22e-0379232IPR019787
DomainPHD

KMT2A PHF8

5.32e-0389232SM00249
DomainTRYPSIN_SER

PRSS55 MASP2

5.44e-0390232IPR033116
DomainZnf_PHD

KMT2A PHF8

5.56e-0391232IPR001965
DomainZF_PHD_2

KMT2A PHF8

6.04e-0395232PS50016
DomainZF_PHD_1

KMT2A PHF8

6.17e-0396232PS01359
DomainTRYPSIN_HIS

PRSS55 MASP2

7.07e-03103232IPR018114
DomainTRYPSIN_SER

PRSS55 MASP2

7.47e-03106232PS00135
DomainTRYPSIN_HIS

PRSS55 MASP2

7.61e-03107232PS00134
DomainPeptidase_S1A

PRSS55 MASP2

8.45e-03113232IPR001314
DomainTRYPSIN_DOM

PRSS55 MASP2

8.74e-03115232PS50240
DomainTryp_SPc

PRSS55 MASP2

9.03e-03117232SM00020
DomainTrypsin

PRSS55 MASP2

9.64e-03121232PF00089
DomainTrypsin_dom

PRSS55 MASP2

9.64e-03121232IPR001254
DomainPeptidase_S1_PA

PRSS55 MASP2

9.94e-03123232IPR009003
Pubmed

A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

KMT2A PICALM

4.56e-07224212461747
Pubmed

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.

PICALM CLTC

2.74e-06424214985334
Pubmed

Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.

PICALM CLTC

4.56e-06524210436022
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

ZC3H7B MKRN4P BRDT LRRC53 PHF8

1.96e-0549624531343991
Pubmed

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

PICALM CLTC

2.05e-051024226005850
Pubmed

CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

PICALM CLTC

2.05e-051024225898166
Pubmed

GGA2 and RAB13 promote activity-dependent β1-integrin recycling.

PICALM CLTC

7.75e-051924231076515
Pubmed

LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.

KRT2 CLTC

1.05e-042224225982273
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

PICALM CLTC

1.05e-042224226950368
Pubmed

F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.

KRT2 CLTC

1.14e-042324224390425
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

PICALM CLTC

1.47e-042624224067654
Pubmed

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

PICALM CLTC

2.24e-043224228388416
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KMT2A PHF8

2.38e-043324226864203
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

KMT2A KRT2 CLTC

3.57e-0420224324639526
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

BRDT KMT2A PHF8 CLTC

4.54e-0453324430554943
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KMT2A PHF8

5.26e-044924234368113
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

KMT2A PICALM

5.48e-045024237974198
Pubmed

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

GPM6A CLTC

5.48e-045024224769233
Pubmed

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

GPM6A CLTC

5.93e-045224220114047
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PTPRM KRT2 PHF8 CLTC CCDC77

6.52e-04104924527880917
CytobandEnsembl 112 genes in cytogenetic band chr11q23

BACE1 KMT2A

5.89e-03220242chr11q23
CytobandEnsembl 112 genes in cytogenetic band chrXp11

MKRN4P PHF8

1.65e-02377242chrXp11
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPM6A TCEA3 MASP2

9.77e-05168243b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

ZCWPW2 PTPRM PLCB4

1.32e-041862432e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

ZCWPW2 PTPRM PLCB4

1.32e-04186243c3449e54454009973818fc1101933c6f0168258c
ToppCellCOPD-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

ZCWPW2 PTPRM PLCB4

1.34e-04187243be42ee71d3412bb1f52593d8814de85c354a0efa
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial-endothelial_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PICALM PLCB4

1.45e-041922430986b7900021efe2a4df84a935e7c9a0af1b0e57
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRM GPM6A PLCB4

1.45e-041922431ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PICALM PLCB4

1.45e-04192243b28d294e42b303d1db6060231d84d7b9e4d9fccf
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM PICALM PLCB4

1.45e-041922438f20d3511dcb44445592b17d005a53da0052ae56
ToppCellCOPD-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

ZCWPW2 GPM6A PLCB4

1.47e-0419324325bdc557055b5bce6a21f8696b48e991c696b979
ToppCellControl-Endothelial-Lymphatic|Control / Disease state, Lineage and Cell class

ZCWPW2 GPM6A PLCB4

1.47e-0419324364d19be73e5432d491436a01da5de5c926b615a9
ToppCellIPF-Endothelial-VE_Arterial|IPF / Disease state, Lineage and Cell class

ZCWPW2 PTPRM PLCB4

1.47e-04193243bf83b1fe9d38408f30eee4eb634341c04ef82791
ToppCellCOPD-Endothelial-VE_Arterial|COPD / Disease state, Lineage and Cell class

ZCWPW2 PTPRM PLCB4

1.47e-041932431c701b6ab5f0f0239634adac94fa1c92bf3c36f4
ToppCell(4)_Endothelial_cells-(42)_EC-sinusoidal|World / Cell class and subclass of bone marrow stroma cells in homeostatis

GPM6A PICALM CLTC

1.49e-041942434428b472c2042f88eae028b1770767512a515b75
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRM GPM6A PLCB4

1.49e-04194243b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell(4)_Endothelial_cells-(42)_EC-sinusoidal|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

GPM6A PICALM CLTC

1.49e-041942434199900d16623eca02d674d5ada7f0989e47955e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PTPRM GPM6A PLCB4

1.52e-0419524377e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PTPRM KMT2A PLCB4

1.63e-04200243dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PTPRM KMT2A PICALM

1.63e-042002432d07237022b409c4fac6fcf99b68c8affb3007cd
Diseaseprostate cancer (is_marker_for)

KMT2A FGF7 PHF8

2.70e-04156243DOID:10283 (is_marker_for)
DiseaseCleft upper lip

FGF7 PHF8

4.61e-0439242C0008924
DiseaseCleft Palate

FGF7 PLCB4

1.98e-0381242C0008925
Diseaseacute myeloid leukemia (is_implicated_in)

KMT2A PICALM

2.12e-0384242DOID:9119 (is_implicated_in)
DiseaseAcute Confusional Senile Dementia

BACE1 PICALM

2.93e-0399242C0546126
DiseasePresenile dementia

BACE1 PICALM

2.93e-0399242C0011265
DiseaseAlzheimer's Disease, Focal Onset

BACE1 PICALM

2.93e-0399242C0750900
DiseaseAlzheimer Disease, Early Onset

BACE1 PICALM

2.93e-0399242C0750901
DiseaseAlzheimer Disease, Late Onset

BACE1 PICALM

2.93e-0399242C0494463
DiseaseFamilial Alzheimer Disease (FAD)

BACE1 PICALM

2.99e-03100242C0276496
DiseaseAlzheimer's Disease

BACE1 PICALM

3.05e-03101242C0002395
DiseaseAcute Myeloid Leukemia, M1

KMT2A PICALM

4.62e-03125242C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

KMT2A PICALM

4.62e-03125242C1879321
Diseaseneuroticism measurement

ZC3H7B PRSS55 GPM6A KMT2A

5.81e-03909244EFO_0007660
DiseaseLeukemia, Myelocytic, Acute

KMT2A PICALM

8.67e-03173242C0023467
Diseasemental or behavioural disorder

PTPRM PHF8

9.25e-03179242EFO_0000677

Protein segments in the cluster

PeptideGeneStartEntry
GQDLKMDCKEYNYDK

BACE1

271

P56817
TIKEKMDNQEYKDAY

BRDT

321

Q58F21
KELLEYYQKKMAECE

CCDC77

56

Q9BR77
YYQKKMAECEAENED

CCDC77

61

Q9BR77
MLFKQKKNSCYADGD

AKAP11

1281

Q9UKA4
YKEAMSNKACKYFDE

MKRN4P

396

Q13434
YVKDACRMQKYEDIK

GPM6A

241

P51674
YVPCEQFEDYMKEKK

LRRC53

576

A6NM62
NMQDLVEDYKKKYED

KRT2

256

P35908
DKNDEEYMKYLAYKQ

FUT11

341

Q495W5
YTMKVNDGKYVCEAD

MASP2

401

O00187
YDDDDYESKMMQCGK

KMT2A

1576

Q03164
MNKEGKLYAKKECNE

FGF7

121

P21781
QMKCAEGYGFKEEYE

PTPRM

891

P28827
QNEEFDKDYQKKMAG

SULT1C3

281

Q6IMI6
QQYKMSKYCEDLFGD

PLCB4

416

Q15147
NKYKYEECKDLIKSM

NBPF7P

76

P0C2Y1
ELCKKDSLYKDAMQY

CLTC

1526

Q00610
KYFDMKKNQCKEGLD

PICALM

221

Q13492
ADDDYKDYGVNCDKM

TCEA3

201

O75764
KNMLCAGYKNESYDA

PRSS55

231

Q6UWB4
EKSYRPNDYEKDNMK

ZNF226

221

Q9NYT6
QADCKMKLGDFVKYY

PHF8

201

Q9UPP1
MDKEKLDVKIEYCNY

ZCWPW2

1

Q504Y3
KDMINKQDCKYGDNC

ZC3H7B

486

Q9UGR2