Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

JAK2 USP8 STXBP1 PTPRD MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 ALG13

3.50e-066638613GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

JAK2 USP8 STXBP1 PTPRD MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 ALG13

3.56e-066648613GO:0099177
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

JAK2 USP8 STXBP1 PTPRD CLCN3 MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 SLC1A2 ALG13

6.36e-069318615GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

JAK2 USP8 STXBP1 PTPRD CLCN3 MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 SLC1A2 ALG13

6.36e-069318615GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

JAK2 USP8 STXBP1 PTPRD CLCN3 MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 SLC1A2 ALG13

7.05e-069398615GO:0099537
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

STXBP1 CLCN3 MYO6 STXBP5L SYNE1 DNM1L UNC13C GRIK5 PICALM

7.70e-06321869GO:0099003
GeneOntologyBiologicalProcesssynaptic signaling

JAK2 USP8 STXBP1 PTPRD CLCN3 MYO6 STXBP5L SYNE1 ICA1 DNM1L UNC13C GRIK5 PLCL1 SLC1A2 ALG13

1.12e-059768615GO:0099536
GeneOntologyBiologicalProcessneurotransmitter transport

STXBP1 STXBP5L ICA1 DNM1L UNC13C GRIK5 SLC1A2

1.05e-04259867GO:0006836
GeneOntologyBiologicalProcesssynaptic vesicle cycle

STXBP1 CLCN3 STXBP5L DNM1L UNC13C GRIK5 PICALM

1.18e-04264867GO:0099504
GeneOntologyBiologicalProcesssignal release from synapse

STXBP1 STXBP5L ICA1 DNM1L UNC13C GRIK5

1.66e-04195866GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

STXBP1 STXBP5L ICA1 DNM1L UNC13C GRIK5

1.66e-04195866GO:0007269
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

STXBP1 STXBP5L DNM1L UNC13C GRIK5

1.77e-04125865GO:0016079
GeneOntologyBiologicalProcesssynaptic vesicle maturation

STXBP1 CLCN3 PICALM

2.36e-0429863GO:0016188
GeneOntologyCellularComponentextrinsic component of plasma membrane

JAK2 STXBP1 GNG7 PICALM PPL RYR1

2.17e-05137866GO:0019897
GeneOntologyCellularComponentextrinsic component of membrane

JAK2 STXBP1 PIK3CG GNG7 PICALM PPL RYR1

4.58e-05230867GO:0019898
GeneOntologyCellularComponentpresynaptic endocytic zone

MYO6 DNM1L PICALM

5.25e-0518863GO:0098833
GeneOntologyCellularComponentglutamatergic synapse

JAK2 USP8 STXBP1 PTPRD CLCN3 MYO6 SPTAN1 RTN3 GRIK5 ARHGAP39 PDE10A SLC1A2

1.26e-048178612GO:0098978
GeneOntologyCellularComponentpresynaptic membrane

STXBP1 PTPRD DNM1L UNC13C GRIK5 SLC1A2 PICALM

1.46e-04277867GO:0042734
GeneOntologyCellularComponentpresynapse

STXBP1 PTPRD CLCN3 SEPTIN4 MYO6 ICA1 RTN3 DNM1L UNC13C GRIK5 SLC1A2 PICALM

2.66e-048868612GO:0098793
GeneOntologyCellularComponentsecretory vesicle

USP8 STXBP1 CLCN3 SEPTIN4 STXBP5L SPTAN1 ICA1 PKP1 DNM1L UNC13C ICA1L PICALM FERMT3 COL1A1

5.34e-0412468614GO:0099503
GeneOntologyCellularComponentsynaptic membrane

STXBP1 PTPRD CLCN3 SYNE1 DNM1L UNC13C GRIK5 SLC1A2 PICALM

6.55e-04583869GO:0097060
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

STXBP1 UNC13C PICALM

7.37e-0443863GO:0098688
GeneOntologyCellularComponentpostsynapse

JAK2 USP8 STXBP1 CLCN3 MYO6 SYNE1 SPTAN1 RTN3 GRIK5 ARHGAP39 SLC1A2 PICALM

9.16e-0410188612GO:0098794
GeneOntologyCellularComponentpresynaptic endocytic zone membrane

DNM1L PICALM

1.47e-0314862GO:0098835
GeneOntologyCellularComponentsynaptic vesicle

CLCN3 SEPTIN4 ICA1 DNM1L UNC13C PICALM

1.49e-03300866GO:0008021
GeneOntologyCellularComponentextrinsic component of cytoplasmic side of plasma membrane

JAK2 GNG7 RYR1

1.59e-0356863GO:0031234
GeneOntologyCellularComponentexocytic vesicle

CLCN3 SEPTIN4 ICA1 DNM1L UNC13C PICALM

2.07e-03320866GO:0070382
DomainICA69

ICA1 ICA1L

2.10e-052862PF04629
DomainIslet_autoAg_Ica1_C

ICA1 ICA1L

2.10e-052862IPR006723
DomainICA69

ICA1 ICA1L

2.10e-052862SM01237
DomainIslet_autoAg_Ica1/Ica1-like

ICA1 ICA1L

2.10e-052862IPR024114
DomainAH_dom

ICA1 ICA1L

2.08e-045862IPR010504
DomainArfaptin

ICA1 ICA1L

2.08e-045862PF06456
DomainArfaptin

ICA1 ICA1L

2.08e-045862SM01015
DomainAH

ICA1 ICA1L

2.08e-045862PS50870
DomainSpectrin_repeat

SYNE1 SPTAN1 PPL

3.16e-0429863IPR002017
DomainSpectrin/alpha-actinin

SYNE1 SPTAN1 PPL

4.25e-0432863IPR018159
DomainSPEC

SYNE1 SPTAN1 PPL

4.25e-0432863SM00150
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MDN1 PTPRD NACC1 SYNE1 SPTAN1 DOCK7 DNM1L GRIK5 PLCL1 ARHGAP39 SLC1A2 DDB1 PICALM FERMT3

1.58e-07963891428671696
Pubmed

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

MYO6 DOCK7 DDB1 PICALM

2.83e-072289426950368
Pubmed

Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.

MYO6 DOCK7

6.48e-06289227018747
Pubmed

Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.

ZFHX3 MUC5AC

6.48e-06289217330845
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

STXBP1 SYNE1 SPTAN1 PKP1 DNM1L PLCL1 ARHGAP39

8.17e-0628189728706196
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

ANKRD36B SYNE1 SPTAN1 ANKRD36 EIF3D MUC5AC

8.95e-0618789626460568
Pubmed

Amplification of Glyceronephosphate O-Acyltransferase and Recruitment of USP30 Stabilize DRP1 to Promote Hepatocarcinogenesis.

DNM1L GNPAT

1.94e-05389230143522
Pubmed

CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

JAK2 CCR7

1.94e-05389212393730
Pubmed

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.

DNM1L COL1A1

1.94e-05389232059807
Pubmed

Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.

JAK2 RTN3

1.94e-05389235596061
Pubmed

Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.

PIK3CG CCR7

1.94e-05389219615795
Pubmed

ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.

ICA1 ICA1L

1.94e-05389226306493
Pubmed

ClC-3 Deficiency Impairs the Neovascularization Capacity of Early Endothelial Progenitor Cells by Decreasing CXCR4/JAK-2 Signalling.

JAK2 CLCN3

1.94e-05389231679624
Pubmed

CCR7 regulates cell migration and invasion through JAK2/STAT3 in metastatic squamous cell carcinoma of the head and neck.

JAK2 CCR7

1.94e-05389225405202
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP8 RBM11 STXBP1 PTPRD MYO6 HIPK1 SYNE1 SPTAN1 ASB3 GAS7 ANKRD36 EIF3D RECK

2.33e-051285891335914814
Pubmed

CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma.

USP49 PKP1 MED23 COL1A1

2.41e-056589434431227
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

STXBP1 STXBP5L HIPK1 SPTAN1 RTN3 ARHGAP39 SLC1A2

3.17e-0534789717114649
Pubmed

CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.

JAK2 CCR7

3.87e-05489232017846
Pubmed

Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection.

CCR7 CD163

3.87e-05489236139418
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 MKS1

3.87e-05489219596800
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SYNE1 SPTAN1 GRIK5 PLCL1 ARHGAP39 SLC1A2

4.69e-0525189627507650
Pubmed

ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.

SEPTIN4 BIRC3

6.44e-05589221695558
Pubmed

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

STXBP1 STXBP5L

6.44e-05589215659226
Pubmed

Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells.

JAK2 PIK3CG

6.44e-05589218771702
Pubmed

Mutations in DCHS1 cause mitral valve prolapse.

HABP2 COL1A1

6.44e-05589226258302
Pubmed

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

AREL1 SEPTIN4

6.44e-05589223479728
Pubmed

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.

JAK2 PICALM

6.44e-05589225552701
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

STXBP1 SEPTIN4 MYO6 SYNE1 SPTAN1 NCKIPSD DOCK7 RTN3 DNM1L PLCL1 ARHGAP39 SLC1A2 DDB1

7.03e-051431891337142655
Pubmed

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.

CLCN3 RTN3 DDB1 PICALM PPL

7.84e-0517089536470425
Pubmed

HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction.

DNM1L DDB1

9.65e-05689222438978
Pubmed

Development and transdifferentiation into inner hair cells require Tbx2.

IKZF2 MYO6

9.65e-05689236687561
Pubmed

Common variants in FOXP1 are associated with generalized vitiligo.

ICA1 PDE10A

9.65e-05689220526340
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

JAK2 MYO6 STXBP5L RTN3 ZFHX3 ANKMY1 ARHGAP39 PDE10A TEP1 SLC4A5 ICA1L SLC25A37 RECK

1.05e-041489891328611215
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

MDN1 CLCN3 SETD6 SPTAN1 PEX3 GAS7 DNM1L HABP2 PLCL1 PLK4 RYR1 ALG13

1.12e-041293891215342556
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

JAK2 KRT26 MDN1 NACC1 ICA1 TBC1D2 GRIK5 EIF3D RYR1

1.14e-0473689929676528
Pubmed

Helios is a key transcriptional regulator of outer hair cell maturation.

IKZF2 MYO6

1.35e-04789230464345
Pubmed

The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.

SEPTIN4 BIRC3

1.35e-04789221869827
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

PTPRD PKP1 UNC13C SLC1A2

1.35e-0410189418519826
Pubmed

Huntingtin interacting proteins are genetic modifiers of neurodegeneration.

STXBP1 SPTAN1 SLC1A2 DDB1 PPL

1.56e-0419789517500595
Pubmed

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia.

PIK3CG DDB1 FERMT3

1.61e-044189319786618
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

STXBP1 SEPTIN4 MYO6 SPTAN1 NCKIPSD GRIK5 SLC1A2 PICALM

1.96e-0462189822794259
Pubmed

The DNA sequence and analysis of human chromosome 6.

ZBTB2 MDN1 MYO6 SYNE1 PEX3 GPSM3 PDE10A MED23

1.98e-0462289814574404
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MDN1 SYNE1 SPTAN1 RTN3 ZFHX3 DDB1 PICALM RYR1 ALG13

2.26e-0480789930575818
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

STXBP1 SYNE1 TEP1 ICA1L RYR1

2.30e-0421489522199357
Pubmed

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.

PIK3CG SPTAN1

2.30e-04989210571082
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ANKRD36B USP8 RBM11 MDN1 STXBP1 MYO6 NACC1 RYR1

2.35e-0463889831182584
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

SPTAN1 TBC1D2 DOCK7 PPL

2.46e-0411889430979931
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MDN1 MYO6 SYNE1 SPTAN1 DOCK7 PKP1 RTN3 BIRC3 DNM1L EIF3D MED23 DDB1

2.75e-041425891230948266
Pubmed

The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.

STXBP1 SEPTIN4

2.88e-041089211739749
Pubmed

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

RBM11 PKP1 GAS7 DDB1

3.36e-0412889423858473
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

ZBTB2 IKZF2 MDN1 MED23

3.46e-0412989423022380
Pubmed

PEX14 is required for microtubule-based peroxisome motility in human cells.

PEX3 DNM1L GNPAT

3.66e-045489321525035
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

STXBP1 MYO6 SPTAN1 PDE10A

3.66e-0413189428634551
Pubmed

Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.

IKZF2 MYO6

4.20e-041289237171961
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

STXBP1 MYO6 DOCK7 GAS7 PICALM FERMT3

4.25e-0437789638117590
Pubmed

Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis.

DNM1L COL1A1

4.96e-041389236754021
Pubmed

Loss of flow responsive Tie1 results in Impaired
Aortic valve remodeling.

HABP2 COL1A1

5.78e-041489231319059
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

STXBP1 SPTAN1 RTN3 DNM1L PDE10A SLC1A2

6.03e-0440389630562941
Pubmed

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

PTPRD PIK3CG

6.65e-041589220526338
Pubmed

Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction.

HABP2 COL1A1

7.59e-041689225300579
Pubmed

Defining the membrane proteome of NK cells.

MDN1 CLCN3 MYO6 PIK3CG PEX3 DNM1L EIF3D PICALM FERMT3 GNPAT

8.08e-041168891019946888
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

STXBP1 SEPTIN4 SPTAN1 RTN3

8.33e-0416389416512683
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

DOCK7 EIF3D DDB1

8.50e-047289336376293
Pubmed

CEBPA-Associated Familial Acute Myeloid Leukemia (AML)

JAK2 PICALM

8.59e-041789220963938
Pubmed

ETV6 Thrombocytopenia and Predisposition to Leukemia

JAK2 PICALM

8.59e-041789233226740
Pubmed

RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies

JAK2 PICALM

8.59e-041789233661592
Pubmed

Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.

RBM11 DNAJC28

8.59e-041789212036298
Pubmed

Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.

JAK2 GAS7

8.59e-041789219861958
Pubmed

DDX41-Associated Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia

JAK2 PICALM

9.65e-041889234723452
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

ZNF716 MDN1 PPL COL1A1

9.74e-0417089423314748
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

PTPRD MYO6 ZFHX3 PDE10A

9.95e-0417189420201926
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

USP8 NACC1 SPTAN1 NCKIPSD DOCK7 ALG13

1.02e-0344689624255178
Pubmed

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

MDN1 DNM1L DDB1

1.11e-037989326446488
Pubmed

Bioinformatics and cellular signaling.

PIK3CG RTN3 BIRC3 RYR1

1.25e-0318289415102471
Pubmed

Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.

SPTAN1 GPSM3

1.32e-032189212202484
Pubmed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.

MUC5AC COL1A1

1.45e-032289220430747
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

MYO6 SPTAN1 DOCK7 DDB1

1.50e-0319189433762435
Pubmed

A human MAP kinase interactome.

MYO6 HIPK1 SYNE1 SPTAN1 GAS7 SLC1A2

1.58e-0348689620936779
Pubmed

The small GTPase Rac1 regulates auditory hair cell morphogenesis.

MYO6 SPTAN1

1.58e-032389220016102
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

ZBTB2 ZFHX3 DDB1

1.67e-039189320362542
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CLCN3 GRIK5

1.72e-032489222534482
Pubmed

Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.

SYNE1 COL1A1

1.87e-032589212358155
Pubmed

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

JAK2 SPTAN1

1.87e-03258928493579
Pubmed

ABCE1 is a highly conserved RNA silencing suppressor.

MDN1 MYO6 EIF3D MED23

1.90e-0320489425659154
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

STXBP1 UNC13C

2.02e-032689217124501
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

DOCK7 DNM1L PPL RYR1

2.04e-0320889433230847
Pubmed

Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins.

SPTAN1 DDB1 PPL

2.07e-039889326561776
Pubmed

Quantitative analysis of PPT1 interactome in human neuroblastoma cells.

SPTAN1 DOCK7 DNM1L DDB1

2.11e-0321089426217791
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PIK3CG PDE10A

2.18e-032789211156964
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ANKRD36B ANKRD36 FANCM

2.25e-0310189310997877
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SYNE1 DOCK7 ARHGAP39

2.32e-0310289311214970
Pubmed

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

USP8 DDB1

2.34e-032889222118674
Pubmed

A functional reference map of the RNF8 interactome in cancer.

MDN1 SPTAN1 PKP1 DDB1

2.42e-0321889435831895
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

AREL1 MDN1 MYO6

2.45e-031048939205841
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

MDN1 SPTAN1 DDB1 PICALM

2.46e-0321989431353912
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF716 ZNF679

2.51e-032989214563677
Pubmed

A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.

CCR7 COL1A1

2.51e-032989237160119
GeneFamilyClassical BAR domain containing

ICA1 ICA1L

3.41e-0486421292
CoexpressionGSE40273_GATA1_KO_VS_WT_TREG_DN

SETD6 SYNE1 SPTAN1 BIRC3 CCR7 TEP1 SLC25A37

4.38e-06200867M9133
CoexpressionZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_DN

ANKRD36B IKZF2 MDN1 CD7 TRAT1 SYNE1 CLK4 SPTAN1 CCR7 PLCL1 EIF3D GNG7 RECK

2.50e-0510128613M40864
CoexpressionVILIMAS_NOTCH1_TARGETS_UP

CD7 TRAT1 BIRC3 CCR7

2.59e-0552864MM1249
CoexpressionVILIMAS_NOTCH1_TARGETS_UP

CD7 TRAT1 BIRC3 CCR7

2.59e-0552864M1869
CoexpressionGSE11864_CSF1_VS_CSF1_PAM3CYS_IN_MAC_UP

SYNE1 SPTAN1 RTN3 GNG7 JHY GNPAT

4.77e-05197866M3136
CoexpressionGSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN

TRAT1 ICA1 BIRC3 PLCL1 RYR1 JHY

5.04e-05199866M8044
ToppCellmild_COVID-19_(asymptomatic)-CD4+_T_naive|World / disease group, cell group and cell class (v2)

CNNM1 RBM11 TRAT1 BIRC3 CCR7 PLCL1 SLC4A5

2.99e-0815789723879e65a6acc33d9aad096cd23604a77b0ac9c2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B STXBP1 STXBP5L SYNE1 ICA1 RTN3 ANKRD36

1.36e-07196897676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellAT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

LRRC55 STXBP1 MYO6 BIRC3 ATP10B HABP2 COL1A1

1.41e-071978975e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANKRD36B STXBP1 STXBP5L SYNE1 ICA1 RTN3 ANKRD36

1.56e-0720089748d801219bc771d6c7e151dc88ca4c179988de85
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 SPTAN1 ICA1 BIRC3 CCR7 PLCL1

6.45e-071538967480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IKZF2 SPTAN1 ICA1 BIRC3 CCR7 PLCL1

7.23e-0715689653ded973358e3e48054130131e959f0d1f4ef60f
ToppCellmild_COVID-19_(asymptomatic)-CD4+_T_naive|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

CNNM1 RBM11 CD7 TRAT1 CCR7 SLC4A5

1.08e-0616789678d264af390bd89942ffbb2991dc94f50756d4c9
ToppCell15-Distal-Immune-Hematopoietic,_T_Cells|Distal / Age, Tissue, Lineage and Cell class

IKZF2 CD7 TRAT1 PIK3CG CCR7 FERMT3

1.95e-06185896481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PIK3CG BIRC3 CCR7 CD163 RYR1 FERMT3

2.21e-06189896440c422369de1c49112d18cf8c506a2a3a81f6ba
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

IKZF2 CD7 TRAT1 BIRC3 CCR7 PLCL1

2.28e-061908962a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PIK3CG BIRC3 CCR7 CD163 RYR1 FERMT3

2.28e-06190896e0b363f772817cfc6ab425430805c1cddcba23f0
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-Treg|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IKZF2 CD7 TRAT1 GPSM3 BIRC3 CCR7

2.28e-06190896fe6fecdf2123f3a4fb20e7535472d562b1a74fb4
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

IKZF2 CD7 TRAT1 GPSM3 BIRC3 CCR7

2.35e-06191896133864ec1e89f97a82c3bb01d2a3c658397fefaf
ToppCell(0)_T_CD4|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CD7 TRAT1 GPSM3 BIRC3 CCR7 FERMT3

2.35e-06191896ba289658777a2669fda9da9128e87adb60fd8430
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-Treg|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IKZF2 CD7 TRAT1 GPSM3 BIRC3 CCR7

2.49e-06193896f3eb295a019de29f484964f00ea436860af249a5
ToppCell11.5-Airway-Immune-Hematopoietic,_T_Cells|Airway / Age, Tissue, Lineage and Cell class

CD7 TRAT1 GPSM3 BIRC3 CCR7 FERMT3

2.49e-061938967c14bc481ed38378b9e6a85f768a1e526c5997e6
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BIRC3 CCR7 GNG7 CD163 RYR1 FERMT3

2.64e-06195896e8fb552f9ab77b656c27abc66af523b56cd9f9ad
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRAT1 HIPK1 BIRC3 CCR7 ANKRD36 ALG13

2.64e-06195896ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell(0)_NK/T_cells|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CD7 TRAT1 GPSM3 BIRC3 CCR7 FERMT3

2.72e-06196896baee29014dc56c71a6ef790bb7ecd5b5271cfcb0
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IKZF2 SYNE1 SPTAN1 BIRC3 CCR7 ANKRD36

2.81e-06197896c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

IKZF2 SPTAN1 ICA1 BIRC3 CCR7 PLCL1

2.81e-06197896de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STXBP1 STXBP5L SYNE1 ICA1 RTN3 ANKRD36

2.89e-061988966d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD36B STXBP1 STXBP5L ICA1 RTN3 ANKRD36

2.89e-061988960ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-Treg|Leuk-UTI / Disease, condition lineage and cell class

IKZF2 TRAT1 SPTAN1 ICA1 BIRC3 PLCL1

2.97e-06199896100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IKZF2 CD7 TRAT1 GPSM3 BIRC3 CCR7

2.97e-06199896da20998253ad08a4a127a98b991b26237edb61a2
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

LRRC55 CNNM1 IKZF2 STXBP5L ICA1 ANKMY1

3.06e-062008960927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|367C / Donor, Lineage, Cell class and subclass (all cells)

IKZF2 CD7 ICA1 BIRC3 ANKRD36

1.08e-0514589529422c908d58081e6a748e362a7ac41bf001444c
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IKZF2 MDN1 GRIK5 PLK4 MKS1

1.24e-0514989565778f19599b4955c0a16f0121237656449431fb
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|368C / Donor, Lineage, Cell class and subclass (all cells)

IKZF2 CD7 ICA1 BIRC3 PLCL1

1.32e-051518955d64655b6b09cc0a6d44629a31048b787a0916c5
ToppCellLeuk-UTI-Lymphocyte-T_NK-Treg|Leuk-UTI / Disease, Lineage and Cell Type

IKZF2 TRAT1 SPTAN1 ICA1 BIRC3

1.40e-05153895b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCellControl-Lymphocyte-T_NK-Treg|Control / Disease, Lineage and Cell Type

IKZF2 TRAT1 ICA1 BIRC3 PLCL1

1.64e-05158895260dc209f619e1d17a11cede979636001c749786
ToppCellHealthy/Control-Treg|Healthy/Control / Disease group and Cell class

IKZF2 ICA1 BIRC3 PLCL1 PPL

1.69e-0515989516a322760c99f3e2c3b73cbb399f77868951d3cb
ToppCellHealthy/Control-Treg|World / Disease group and Cell class

IKZF2 ICA1 BIRC3 PLCL1 PPL

1.80e-05161895457297cda5c9cee3bcc069fdecbbe24def027e5f
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 ICA1 BIRC3 CCR7 PLCL1

2.02e-051658954edc9714185a7519a7044487a3d6ea845131b851
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IKZF2 ICA1 BIRC3 CCR7 PLCL1

2.02e-05165895fd1d38b97564c1f64f5c7246dcec96d60364b7b2
ToppCelldroplet-Marrow-BM-30m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEP1A HIPK1 SYNE1 ZFHX3 RECK

2.08e-05166895019d365df44c3bbd88c1f4bdceb3de0ff76d3e8d
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF2 CD7 TRAT1 CCR7 FANCM

2.20e-05168895ade02beb8d663fce4be2aefa10392ab849a4bbe7
ToppCellCOVID-19_Moderate-Treg|World / disease group, cell group and cell class

IKZF2 TRAT1 ICA1 BIRC3 PLCL1

2.27e-0516989527ad11239559b025bef582f89b2a83501d9d3993
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD7 GPSM3 CCR7 TEP1 RYR1

2.40e-0517189587cb65648c663e246f94cea1a5ed12e8e29ec629
ToppCelldroplet-Trachea-nan-3m-Myeloid-macrophage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD7 GPSM3 CCR7 TEP1 RYR1

2.47e-05172895f6c00a6a7e81aaf96c55eb3a3c88e3719f102ea0
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD7 GPSM3 CCR7 TEP1 RYR1

2.47e-05172895f3bbe3f069ad070778430d1a6cd9db0a76deb8de
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 TRAT1 ICA1 BIRC3 ANKRD36

2.47e-051728959497948bbe53fb88c6ff6b347f743d456da587e5
ToppCellcontrol-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

2.54e-051738950c9fb18536ddd61b51b7bb4d40841f67b017f360
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD7 SLC1A2 CD163 RYR1 MKS1

2.61e-05174895ff13a5c55d18b951315908f33cb47c7f9cb901bf
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD7 TRAT1 GPSM3 CCR7 PLCL1

2.75e-051768959d4a4dfeebb5a8a0f3ab18c37c8ddc2cd2158575
ToppCellfacs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPC1L IKZF2 TRAT1 PKP1 FERMT3

2.75e-05176895acd05ca8952710feedbfe377b1330f3c2406d044
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3CG BIRC3 GAS7 CCR7 TTLL13

2.75e-051768955f8c1f917fba49f3b1c0d88b946eca242b668fde
ToppCell10x3'2.3-week_14-16-Lymphocytic_T-T_NK-Treg|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

IKZF2 CD7 TRAT1 BIRC3 CCR7

2.75e-051768952eb1827171e9c19f945e87824215721f8cf22258
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT-T_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD7 TRAT1 GPSM3 CCR7 PLCL1

2.75e-05176895bb41e9478373726eb460af764de0277b2d09928e
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-ILC2|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD7 TRAT1 PIK3CG BIRC3 FERMT3

2.83e-051778959828504591599619649d41a78daf7c052729c669
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 TRAT1 ICA1 BIRC3 ANKRD36

2.91e-0517889590dedb3cef9b01907b9f8eec64218d6d2072be1f
ToppCellControl-Lymphocytic_NKT-T_cells-T-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD7 TRAT1 GPSM3 BIRC3 CCR7

2.91e-05178895910f8bea19d335455aba24e6a07b4834b709db5d
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 TRAT1 ICA1 BIRC3 ANKRD36

2.91e-05178895d6312286bf6cc5b107ccd7adb583d9667d4e1d21
ToppCellControl-Lymphocytic_NKT-T_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD7 TRAT1 GPSM3 BIRC3 CCR7

2.99e-05179895d892d9496f1c33e23312092591eb2e968e736f7d
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

3.07e-051808956bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.15e-051818959b155a74e68e485039a5195144a12833f2f75058
ToppCellPCW_05-06-Immune_Lymphocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TRAT1 PIK3CG CCR7 CD163 FERMT3

3.15e-05181895bd99c5849bb4979c891898312cb9f602c6831b23
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 CD7 TRAT1 CCR7 ICA1L

3.15e-0518189555fcefa234c8fc707b23248e724756d69827cd18
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD4_T|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD7 TRAT1 GPSM3 CCR7 FERMT3

3.23e-051828957dd435e456da1470d19d3db307ae4909c25d2f0d
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IKZF2 CD7 TRAT1 GPSM3 BIRC3

3.23e-051828956bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

JAK2 GAS7 ICA1L PLK4 FERMT3

3.32e-05183895bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCellPCW_05-06-Immune_Lymphocytic-Immune_Lymphocytic_B|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TRAT1 PIK3CG BIRC3 CD163 FERMT3

3.32e-05183895ffa7f2b2929ea4bd53f3f1ae23bd27f8bb4aac47
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.40e-0518489551ae0963b4fb034c3f605ee4e5da513cba7aca35
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

IKZF2 CD7 TRAT1 BIRC3 RYR1

3.40e-0518489533db879e629821fb75684e60f8f0749cf9623bdd
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

3.40e-0518489508bff25390e3484b75c860738396a405141b69fd
ToppCellControl-Lymphocytic_NKT|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.49e-0518589559d68e119f58b35bab36294758f6b2e25fd8f5c0
ToppCellCOPD-Lymphoid-T_Regulatory|COPD / Disease state, Lineage and Cell class

IKZF2 CD7 ICA1 BIRC3 PLCL1

3.49e-05185895846403edd4c8f646201d519055198fc38b7ffff9
ToppCell-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

CD7 BIRC3 CCR7 PDE10A GNG7

3.49e-0518589510f7e5daf8e95dda9453212e84b64874f4e0d7ab
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IKZF2 ICA1 BIRC3 FANCM RYR1

3.59e-05186895bca5215d406f1785bf3a420201d5686071fcaca5
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-Tregs|bone_marrow / Manually curated celltypes from each tissue

IKZF2 ICA1 BIRC3 CCR7 PLCL1

3.68e-05187895bda716a64262325e6e68b281caf131f1840fd298
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 CD7 TRAT1 CCR7 ICA1L

3.68e-0518789516fffe894a2c7d5186556ad000e0be229511fbdb
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

3.77e-051888959db3d3010cb8a1f3ee1cdccaf3cbaac3cf983fc5
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 CD7 TRAT1 CCR7 ICA1L

3.77e-0518889588b808561ebde997ac8a8bbd1d9bbda49bbb6646
ToppCellLPS_only-Lymphocytic_NKT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF2 CD7 TRAT1 CCR7 PLCL1

3.77e-05188895bbe65b1c11c88ab62d8485cfc3a913ff9da89aad
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

IKZF2 ICA1 TBC1D2 SLC1A2 PPL

3.77e-051888950d86044bc340e3efb90d0022dd299873639d831c
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

3.77e-0518889572be6fe654f3a5f654d3b9680145bce7ae9b721d
ToppCellCOVID-19_Mild-Lymphoid_T/NK-Treg|COVID-19_Mild / Disease group, lineage and cell class

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

3.77e-0518889542553fdc127e5f613ffd5067620a768a40f1a8a1
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 TRAT1 ICA1 BIRC3 ANKRD36

3.77e-05188895e5c480b9a030536578f1cc91fb61738f752525b3
ToppCell(1)_T_CD4|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.87e-051898952298a96c53c5bd767e17554c50379b2d1ad8b5b0
ToppCell(1)_T_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.87e-05189895fa6b85676b2b61483ae27720d0715dbfcbcfbdf9
ToppCellmetastatic_Brain-T/NK_cells-CD4+_Th|metastatic_Brain / Location, Cell class and cell subclass

CD7 TRAT1 GPSM3 BIRC3 CCR7

3.87e-05189895a2b00fbe7b7b15db3fce88a56cbac0ef2917332c
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CD7 TRAT1 PIK3CG BIRC3 CCR7

3.87e-05189895620d5a71b8cb6288540e2d2d848b9d4d66c1226f
ToppCell10x5'v1-week_14-16-Lymphocytic_T-T_NK-Treg|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CD7 TRAT1 PKP1 BIRC3 CCR7

3.97e-051908958540f4dee99280109e38b997d9247b176808c51a
ToppCellsevere-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

4.07e-05191895afff6bfae9a2f1e17d2731315e7fe63c4601679f
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IKZF2 TRAT1 ICA1 BIRC3 ANKRD36

4.07e-05191895c5e22df4a8741b8096cdd1618271fd48d6265846
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PIK3CG CCR7 CD163 RYR1 FERMT3

4.07e-0519189509dfad8e1fcaaf94775134796b99e4e3fbb9bf40
ToppCellmetastatic_Brain-T/NK_cells-Naive_CD4+_T|metastatic_Brain / Location, Cell class and cell subclass

CD7 TRAT1 GPSM3 BIRC3 CCR7

4.07e-051918954613eae77e2fbb1c526582de46ffed6bda61ea6b
ToppCellPCW_13-14-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CD7 PIK3CG BIRC3 CCR7 FERMT3

4.07e-0519189514b11244c330cc4fe897253aaaf0df80caa01a55
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

4.17e-051928957a90ec9fc8f29216c4828e0cf5d040906456e53b
ToppCellCOVID-19_Severe-Lymphoid_T/NK-Treg|COVID-19_Severe / Disease group, lineage and cell class

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

4.17e-051928953fb4c148dadcf5e79094e55c6bb53ec7bf9d44c8
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

IKZF2 SPTAN1 ICA1 BIRC3 PLCL1

4.17e-05192895d883b91bbab71673de4858346d3ab33e5fbbf842
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 CD7 ICA1 BIRC3 CCR7

4.17e-05192895d85a785a12076e34c404171363a647f318926b18
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD7 TRAT1 SPTAN1 BIRC3 CCR7

4.17e-051928957ab626a516b07d899175ff12f1c8257688324e4b
ToppCell18-Distal-Immune-Hematopoietic,_T_Cells|Distal / Age, Tissue, Lineage and Cell class

CD7 TRAT1 GPSM3 CCR7 FERMT3

4.17e-051928957538c7f63108f357478ea4c5bf27c1f9825b87c7
ToppCellHealthy_Control-Lymphoid-T-CCR7+_T|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CD7 TRAT1 SYNE1 BIRC3 CCR7

4.17e-051928955b197f65a87c315e4f50c77a7fdec3b342a863ad
ToppCellHealthy-Treg|Healthy / disease group, cell group and cell class

IKZF2 ICA1 BIRC3 CCR7 PLCL1

4.17e-051928959d3795a64bf0c62f460d80730c5615869fc46933
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-Tregs|lymph-node_spleen / Manually curated celltypes from each tissue

IKZF2 ICA1 BIRC3 CCR7 PLCL1

4.17e-0519289591a4d06e8d1d1fe2ce5f72668108513bd2a72c4d
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF2 CD7 ICA1 BIRC3 CCR7

4.17e-05192895230f3090607a62bb6d1e1f4b0341ee96d93f1c00
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-Treg|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

IKZF2 CD7 TRAT1 BIRC3 CCR7

4.17e-051928950deb6aa323e1de72ee8a2002449e523dd4f0bf5d
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRD SEPTIN4 GAS7 ATP10B PLCL1

4.17e-051928958dc3016601148243196e925641c9507e9d58c9e0
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

ICA1 TBC1D2 PKP1 BIRC3 ATP10B CCR7 RYR1 COL1A1

8.12e-071978683940_UP
DrugMetronidazole [443-48-1]; Up 200; 23.4uM; MCF7; HT_HG-U133A

ICA1 PEX3 ATP10B CCR7 GNG7 SLC1A2 COL1A1

9.21e-061958674141_UP
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; MCF7; HT_HG-U133A

DNAJC28 ICA1 ATP10B GRIK5 TEP1 COL1A1 ALG13

9.21e-061958672895_UP
DrugEthionamide [536-33-4]; Up 200; 24uM; PC3; HT_HG-U133A

CD7 MYO6 SYNE1 HABP2 PDE10A GNG7 MUC5AC

9.21e-061958674593_UP
DrugMeclofenoxate hydrochloride [3685-84-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

SPTAN1 ICA1 PKP1 ANKMY1 GNG7 SLC25A37 COL1A1

1.02e-051988673405_UP
Diseasepulmonary fibrosis (biomarker_via_orthology)

DNM1L HABP2 MUC5AC COL1A1

1.46e-0550874DOID:3770 (biomarker_via_orthology)
DiseaseEarly Pregnancy Loss

JAK2 CD7 HABP2 CD163 COL1A1

1.82e-05109875C3830362
DiseaseSpontaneous abortion

JAK2 CD7 HABP2 CD163 COL1A1

1.82e-05109875C0000786
DiseaseMiscarriage

JAK2 CD7 HABP2 CD163 COL1A1

1.82e-05109875C4552766
DiseaseAbortion, Tubal

JAK2 CD7 HABP2 CD163 COL1A1

1.82e-05109875C0000822
Diseasemucinous adenocarcinoma (is_marker_for)

ZFHX3 MUC5AC

8.54e-055872DOID:3030 (is_marker_for)
Diseasecarbamazepine metabolite measurement

GRIK5 PICALM

1.28e-046872EFO_0009891
Diseaseglypican-1 measurement

ANKMY1 HABP2

1.79e-047872EFO_0801649
Diseaseunipolar depression, anorexia nervosa

ASB3 NCKIPSD

3.81e-0410872EFO_0003761, MONDO_0005351
DiseaseLiver Cirrhosis, Experimental

JAK2 CD7 PTPRD SPTAN1 DOCK7 BIRC3 RECK CD163 COL1A1

4.64e-04774879C0023893
DiseaseAcute myeloid leukemia

JAK2 PICALM

1.14e-0317872cv:C0023467
DiseaseLEUKEMIA, ACUTE MYELOID

JAK2 PICALM

1.14e-0317872601626
Diseaseunipolar depression, bipolar disorder

AREL1 SYNE1 GRIK5 PLCL1

1.19e-03156874EFO_0003761, MONDO_0004985
Diseaseprostate carcinoma

IKZF2 STXBP1 PTPRD MYO6 ZFHX3 ANKRD36 PLCL1 SLC25A37 PPL

1.25e-03891879EFO_0001663
DiseaseEpilepsy, Cryptogenic

STXBP1 SLC1A2 ALG13

1.85e-0382873C0086237
DiseaseAwakening Epilepsy

STXBP1 SLC1A2 ALG13

1.85e-0382873C0751111
DiseaseAura

STXBP1 SLC1A2 ALG13

1.85e-0382873C0236018
Diseasepost-traumatic stress disorder symptom measurement

PTPRD PIK3CG SYNE1

1.85e-0382873EFO_0008535
DiseaseNasopharyngeal carcinoma

CLCN3 SYNE1

1.91e-0322872C2931822
DiseaseEczema

JAK2 IKZF2 ATP10B CCR7 PLCL1

2.27e-03310875HP_0000964
Diseasetraumatic brain injury (biomarker_via_orthology)

PDE10A CD163

2.27e-0324872DOID:0081292 (biomarker_via_orthology)
DiseaseWest Syndrome

STXBP1 SPTAN1

2.27e-0324872C0037769
Diseaseparacentral lobule volume measurement

STXBP5L GRIK5

2.47e-0325872EFO_0010317
DiseaseHeart valve disease

JAK2 COL1A1

2.67e-0326872C0018824

Protein segments in the cluster

PeptideGeneStartEntry
MHRLQLSDTGTYTCQ

CD7

101

P09564
RSHRQMSCVNKESQY

ALG13

701

Q9NP73
HEEMQRIIQHCSNYS

DNM1L

436

O00429
YSDLQRSSSEQAMRC

CCR7

196

P32248
NQDFSALMRSSYHCA

BIRC3

151

Q13489
SYHCAMNNENARLLT

BIRC3

161

Q13489
RLETEMQSYHCRLNA

ANKRD36

1596

A6QL64
ASSRHCTYLENGMQD

ANKRD36B

1266

Q8N2N9
RRCTIMGSEYSHQEN

ATP10B

446

O94823
SCVKINSHNYRNEEM

RBM11

101

P57052
MSQTQDYECRSHNVD

ARHGAP39

1

Q9C0H5
TDHMEHNNLCTLYQR

RECK

726

O95980
DLLNCYQMETVRSDN

JAK2

476

O60674
TMQNLNDRLASYLDH

KRT26

86

Q7Z3Y9
TCYMELQVLDLHNNS

LRRC55

86

Q6ZSA7
RQYQICLAIDDSSSM

MDN1

5381

Q9NU22
QLYSTILSHQCQRME

GPSM3

106

Q9Y4H4
SYQQLHTLSDMDLNN

JHY

481

Q6NUN7
HCTNVMAQSVQASRY

MPC1L

86

P0DKB6
QLVQHEILCSMTNSY

HIPK1

176

Q86Z02
NISYITALNMCHQFS

FANCM

1981

Q8IYD8
CMYAILQNNHTLFTD

PDE10A

526

Q9Y233
HLSSLQDYMQRCTNE

PPL

211

O60437
YHFESNQRTCNMTVL

PEX3

56

P56589
DMLLNVDQCSTHLNY

MED23

1276

Q9ULK4
SDCSYIDPMTHNLNR

DNAJC28

231

Q9NX36
QMNSLRAEDTALYHC

IGHV3-20

101

A0A0C4DH32
SMYSLEGNTVEHRCQ

MUC5AC

5566

P98088
MSQQDFCASNRLNHY

OR2AP1

161

Q8NGE2
ERCHNYLQNVSMEAA

IKZF2

216

Q9UKS7
LCNSRQLYDHMIDDS

HABP2

476

Q14520
AYHNSVECLQMLINA

ASB3

51

Q9Y575
LLHSMACNQSAVYLQ

DOCK7

1511

Q96N67
QHITLLMCSAYRNQL

GNPAT

471

O15228
AASDLMSYCEQHARN

GNG7

31

O60262
MKNHRESNSNQCVYA

SLC1A2

526

P43004
CMRNAFHENDTIYSL

CYP4A22

231

Q5TCH4
ATYINHNFSQQCLRM

EIF3D

316

O15371
QLCQAHSQLLQYMER

DDX11L8

416

A8MPP1
NSMSLRDEHNYTLSI

AREL1

201

O15033
ACDLTYEHQRNMDSK

ANKMY1

736

Q9P2S6
DHIRQMAYQICQSIN

CLK4

261

Q9HAZ1
LESTMNEYHRRLNCN

GRIK5

721

Q16478
RCNMLSHSLTTYQRT

ICA1L

216

Q8NDH6
VHQIQYREMNSCLNA

CD163

1091

Q86VB7
NQRSMFDHLSYLLEN

RYR1

2246

P21817
EKELRTECNHYNNIM

DDB1

896

Q16531
LNDVRQSANYTCVAM

PTPRD

291

P23468
ASRCNLLSHMLATYQ

ICA1

221

Q05084
CSEHLQSLYSRTMEA

MROH5

551

Q6ZUA9
SVENCMCVLHNLSYR

PKP1

471

Q13835
SRCVNDMHNFTNEIL

RTN3

326

O95197
ETHYENYRAQCIQSM

SEPTIN4

401

O43236
CSTAQRMYQSLEHEL

SYNE1

4021

Q8NF91
QHLCQYTQLRHETDM

GAS7

421

O60861
ERLNRMYNCTTTHTL

MEP1A

251

Q16819
LQMYNSQHRSAISCI

SLC25A37

171

Q9NYZ2
HNANLEYSANCLRMV

SETD6

256

Q8TBK2
NSQSQAKTYTMERCH

PLK4

386

O00444
SLNEMRCAYEVTQAN

STXBP1

546

P61764
MQTDTQDHQKLCYSA

NCKIPSD

491

Q9NZQ3
TEIQRLTYSQEMCDN

STXBP5L

1046

Q9Y2K9
LESSSLCDYRNDMNA

CLCN3

466

P51790
ITRQQYQNALTACHM

CNNM1

781

Q9NRU3
RLMSTEASQNITYHC

COL1A1

1356

P02452
ENSMSISILLDNYCH

PIK3CG

511

P48736
HLDYLIQCTNEMNVN

PICALM

41

Q13492
LCNRNNMTTHVSFRS

PLCL1

456

Q15111
QCLDHAQQNLYRDVM

ZNF735

31

P0CB33
HENQRLCKSTDYMNL

UNC13C

1646

Q8NB66
MTQADLYRVNNSNCL

TEP1

136

Q99973
SDRYTNLEEHCQRMT

MKS1

131

Q9NXB0
DQKLYMSCIAHSRDQ

THEM5

211

Q8N1Q8
MSCIAHSRDQQTVYA

THEM5

216

Q8N1Q8
QNLTREQADYCVSHM

SPTAN1

2431

Q13813
QCLDHAQQNLYRDVM

ZNF679

31

Q8IYX0
MDCYLTHTNDTAFLQ

TREH

231

O43280
TCYMNSILQVLSHLQ

USP49

261

Q70CQ1
QCLDHAQQNLYRDVM

ZNF716

31

A6NP11
NYGRLCHAQSRSMND

SLC4A5

266

Q9BY07
SDSAQTEACYHMLSR

FERMT3

186

Q86UX7
QATNETQMCYASLDH

TRAT1

101

Q6PIZ9
ARHVCLNQSIDTYTM

ZBTB2

406

Q8N680
CRRQQHMQSTFDNTI

UGT3A2

211

Q3SY77
SCQRQQQLMDQAHIY

TMEM202

41

A6NGA9
RMQDYQDSCILHSLS

USP8

206

P40818
MEAYRTQNCFLNSEI

TBC1D2

461

Q9BYX2
CNVAYSQSSTLEIHM

ZFHX3

1601

Q15911
NNLDNVCMHLTNYAI

TTLL13

281

A6NNM8
NVYITRAQLMNCHVS

NACC1

376

Q96RE7
DNCSLMYLNEATLLH

MYO6

61

Q9UM54