Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2E2 UBE2V1 TAF1L	1.22e-04	37	52	3	GO:0061631
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2E2 UBE2V1 TAF1L	1.91e-04	43	52	3	GO:0061650
GeneOntologyBiologicalProcess	T-helper 2 cell differentiation	KMT2A IL4R NLRP3	1.63e-05	21	49	3	GO:0045064
GeneOntologyBiologicalProcess	error-free postreplication DNA repair	UBE2V1 UBE2V2	1.66e-05	3	49	2	GO:0042275
GeneOntologyBiologicalProcess	T-helper cell differentiation	KMT2A ZFPM1 IL4R NLRP3	6.73e-05	92	49	4	GO:0042093
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell differentiation involved in immune response	KMT2A ZFPM1 IL4R NLRP3	7.32e-05	94	49	4	GO:0002294
GeneOntologyBiologicalProcess	alpha-beta T cell differentiation involved in immune response	KMT2A ZFPM1 IL4R NLRP3	7.63e-05	95	49	4	GO:0002293
GeneOntologyBiologicalProcess	alpha-beta T cell activation involved in immune response	KMT2A ZFPM1 IL4R NLRP3	8.62e-05	98	49	4	GO:0002287
GeneOntologyBiologicalProcess	T cell differentiation involved in immune response	KMT2A ZFPM1 IL4R NLRP3	1.05e-04	103	49	4	GO:0002292
GeneOntologyBiologicalProcess	positive regulation of protein K63-linked ubiquitination	UBE2V1 UBE2V2	1.53e-04	8	49	2	GO:1902523
GeneOntologyBiologicalProcess	positive regulation of T-helper 2 cell differentiation	IL4R NLRP3	1.53e-04	8	49	2	GO:0045630
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell differentiation	KMT2A ZFPM1 IL4R NLRP3	1.83e-04	119	49	4	GO:0043367
GeneOntologyBiologicalProcess	type 2 immune response	KMT2A IL4R NLRP3	3.03e-04	55	49	3	GO:0042092
GeneOntologyBiologicalProcess	T cell activation involved in immune response	KMT2A ZFPM1 IL4R NLRP3	4.20e-04	148	49	4	GO:0002286
GeneOntologyBiologicalProcess	positive regulation of protein modification by small protein conjugation or removal	PIAS3 UBE2V1 UBE2V2 PIAS1	4.41e-04	150	49	4	GO:1903322
GeneOntologyBiologicalProcess	positive regulation of post-translational protein modification	PIAS3 UBE2V1 UBE2V2 PIAS1	4.53e-04	151	49	4	GO:1901875
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell activation	KMT2A ZFPM1 IL4R NLRP3	4.76e-04	153	49	4	GO:0035710
GeneOntologyBiologicalProcess	regulation of protein K63-linked ubiquitination	UBE2V1 UBE2V2	4.94e-04	14	49	2	GO:1900044
GeneOntologyBiologicalProcess	regulation of T-helper 2 cell differentiation	IL4R NLRP3	4.94e-04	14	49	2	GO:0045628
GeneOntologyBiologicalProcess	leukocyte differentiation	PIAS3 NFATC3 TRPM2 KMT2A ZFPM1 MMP14 IL4R NLRP3	4.97e-04	789	49	8	GO:0002521
GeneOntologyBiologicalProcess	alpha-beta T cell differentiation	KMT2A ZFPM1 IL4R NLRP3	5.24e-04	157	49	4	GO:0046632
GeneOntologyCellularComponent	UBC13-MMS2 complex	UBE2V1 UBE2V2	3.49e-05	4	51	2	GO:0031372
GeneOntologyCellularComponent	MLL1 complex	KMT2A CHD8 TAF1L	6.46e-05	32	51	3	GO:0071339
GeneOntologyCellularComponent	MLL1/2 complex	KMT2A CHD8 TAF1L	7.09e-05	33	51	3	GO:0044665
GeneOntologyCellularComponent	postsynaptic cytosol	PIAS3 SENP6 PIAS1	1.81e-04	45	51	3	GO:0099524
GeneOntologyCellularComponent	ubiquitin conjugating enzyme complex	UBE2V1 UBE2V2	2.08e-04	9	51	2	GO:0031371
GeneOntologyCellularComponent	presynaptic cytosol	PIAS3 SENP6 PIAS1	2.33e-04	49	51	3	GO:0099523
GeneOntologyCellularComponent	cytosolic region	PIAS3 SENP6 PIAS1	6.67e-04	70	51	3	GO:0099522
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2A CHD8 TAF1L	8.16e-04	75	51	3	GO:0035097
GeneOntologyCellularComponent	microtubule plus-end	KIF3C NCKAP5L	2.12e-03	28	51	2	GO:0035371
GeneOntologyCellularComponent	methyltransferase complex	KMT2A CHD8 TAF1L	2.33e-03	108	51	3	GO:0034708
Domain	PINIT	PIAS3 PIAS1	4.37e-05	4	51	2	IPR023321
Domain	PINIT	PIAS3 PIAS1	4.37e-05	4	51	2	PS51466
Domain	PINIT	PIAS3 PIAS1	4.37e-05	4	51	2	PF14324
Domain	zf-MIZ	PIAS3 PIAS1	1.52e-04	7	51	2	PF02891
Domain	ZF_SP_RING	PIAS3 PIAS1	1.52e-04	7	51	2	PS51044
Domain	UQ_con	UBE2E2 UBE2V1 UBE2V2	1.64e-04	39	51	3	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2E2 UBE2V1 UBE2V2	1.76e-04	40	51	3	PS00183
Domain	UBQ-conjugat_E2	UBE2E2 UBE2V1 UBE2V2	1.90e-04	41	51	3	IPR000608
Domain	UBIQUITIN_CONJUGAT_2	UBE2E2 UBE2V1 UBE2V2	1.90e-04	41	51	3	PS50127
Domain	Znf_MIZ	PIAS3 PIAS1	2.03e-04	8	51	2	IPR004181
Domain	-	EPHB3 SNHG28 SEMA3F ANTXRL FLNC KALRN NFATC3 IL4R	3.99e-04	663	51	8	2.60.40.10
Domain	p53-like_TF_DNA-bd	NFATC3 TBXT MYRF	4.08e-04	53	51	3	IPR008967
Domain	Ig-like_fold	EPHB3 SNHG28 SEMA3F ANTXRL FLNC KALRN NFATC3 IL4R	6.05e-04	706	51	8	IPR013783
Domain	Pept_M10A_Zn_BS	MMP13 MMP14	7.50e-04	15	51	2	IPR021158
Domain	Hemopexin_CS	MMP13 MMP14	9.68e-04	17	51	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP13 MMP14	1.09e-03	18	51	2	IPR016293
Domain	PG_binding_1	MMP13 MMP14	1.35e-03	20	51	2	PF01471
Domain	Peptidoglycan-bd-like	MMP13 MMP14	1.35e-03	20	51	2	IPR002477
Domain	-	PIAS3 PIAS1	1.49e-03	21	51	2	1.10.720.30
Domain	FN3	EPHB3 FLNC KALRN IL4R	1.62e-03	185	51	4	SM00060
Domain	SAP	PIAS3 PIAS1	1.63e-03	22	51	2	PF02037
Domain	Hemopexin-like_dom	MMP13 MMP14	1.78e-03	23	51	2	IPR000585
Domain	SAP	PIAS3 PIAS1	1.78e-03	23	51	2	SM00513
Domain	Hemopexin-like_repeat	MMP13 MMP14	1.78e-03	23	51	2	IPR018487
Domain	M10A_MMP	MMP13 MMP14	1.78e-03	23	51	2	IPR033739
Domain	Hemopexin	MMP13 MMP14	1.78e-03	23	51	2	PF00045
Domain	HEMOPEXIN	MMP13 MMP14	1.78e-03	23	51	2	PS00024
Domain	-	MMP13 MMP14	1.78e-03	23	51	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP13 MMP14	1.78e-03	23	51	2	PS51642
Domain	HX	MMP13 MMP14	1.78e-03	23	51	2	SM00120
Domain	Pept_M10A	MMP13 MMP14	1.78e-03	23	51	2	IPR021190
Domain	Peptidase_M10	MMP13 MMP14	1.94e-03	24	51	2	PF00413
Domain	SAP	PIAS3 PIAS1	2.11e-03	25	51	2	PS50800
Domain	SAP_dom	PIAS3 PIAS1	2.11e-03	25	51	2	IPR003034
Domain	FN3_dom	EPHB3 FLNC KALRN IL4R	2.52e-03	209	51	4	IPR003961
Domain	ZnMc	MMP13 MMP14	2.83e-03	29	51	2	SM00235
Domain	Peptidase_Metallo	MMP13 MMP14	2.83e-03	29	51	2	IPR006026
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NPC1 SEMA3F FLNC KALRN ZNF592 CHD8 ZFPM1 ZNF839 MMP14 MYRF IL4R REXO1 C6orf132	6.30e-09	1105	52	13	35748872
Pubmed	Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.	UBE2E2 UBE2V1 UBE2V2	1.42e-06	15	52	3	32265276
Pubmed	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	UBE2E2 UBE2V1 UBE2V2	2.11e-06	17	52	3	26489670
Pubmed	Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts.	TGFBI MMP14	2.19e-06	2	52	2	18354229
Pubmed	Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.	NPC1 NLRP3	2.19e-06	2	52	2	30054450
Pubmed	Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.	MMP13 MMP14	2.19e-06	2	52	2	10737763
Pubmed	TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation.	TRPM2 NLRP3	2.19e-06	2	52	2	32058297
Pubmed	Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel.	TRPM2 NLRP3	2.19e-06	2	52	2	31411068
Pubmed	Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme.	MMP13 MMP14	2.19e-06	2	52	2	8663255
Pubmed	TRPM2 links oxidative stress to NLRP3 inflammasome activation.	TRPM2 NLRP3	2.19e-06	2	52	2	23511475
Pubmed	Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons.	PIAS3 PIAS1	2.19e-06	2	52	2	34459572
Pubmed	Knockdown of TRPM2 promotes osteogenic differentiation of human periodontal ligament stem cells by modulating NF-κB /NLRP3 pathway.	TRPM2 NLRP3	6.57e-06	3	52	2	37541115
Pubmed	The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family.	UBE2V1 UBE2V2	6.57e-06	3	52	2	9705497
Pubmed	Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.	UBE2V1 UBE2V2	6.57e-06	3	52	2	9418904
Pubmed	Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers.	MMP13 MMP14	6.57e-06	3	52	2	21840960
Pubmed	The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunity.	UBE2V1 UBE2V2	6.57e-06	3	52	2	24076975
Pubmed	PIAS genes as disease markers in bipolar disorder.	PIAS3 PIAS1	6.57e-06	3	52	2	30861611
Pubmed	PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.	PIAS3 PIAS1	6.57e-06	3	52	2	12077349
Pubmed	Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.	PIAS3 PIAS1	6.57e-06	3	52	2	10854042
Pubmed	Zebrafish Ubc13 is required for Lys63-linked polyubiquitination and DNA damage tolerance.	UBE2V1 UBE2V2	6.57e-06	3	52	2	20556485
Pubmed	IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection.	NT5E NLRP3	6.57e-06	3	52	2	28087471
Pubmed	Mechanical forces-induced human osteoblasts differentiation involves MMP-2/MMP-13/MT1-MMP proteolytic cascade.	MMP13 MMP14	6.57e-06	3	52	2	22006368
Pubmed	Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.	UBE2V1 UBE2V2	6.57e-06	3	52	2	32659264
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	UBE2E2 UBE2V1 UBE2V2	8.99e-06	27	52	3	21143188
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KALRN UBE2V1 NFATC3 UBE2V2 CNKSR3 CHD8 EWSR1 PARD3 CYFIP2	1.16e-05	963	52	9	28671696
Pubmed	Recurrent carcinoma of the rectum, surgical treatment.	UBE2V1 UBE2V2	1.31e-05	4	52	2	14406273
Pubmed	Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.	PIAS3 PIAS1	1.31e-05	4	52	2	15961505
Pubmed	Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.	MMP13 MMP14	1.31e-05	4	52	2	22327326
Pubmed	Aberrant collagenase expression in chronic idiopathic myelofibrosis is related to the stage of disease but not to the JAK2 mutation status.	MMP13 MMP14	1.31e-05	4	52	2	16877349
Pubmed	Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes.	UBE2V1 UBE2V2	1.31e-05	4	52	2	12834344
Pubmed	SUMOylation modulates the transcription repressor function of RIP140.	PIAS3 PIAS1	1.31e-05	4	52	2	18211901
Pubmed	Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.	MMP13 MMP14	1.31e-05	4	52	2	17623673
Pubmed	Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII.	MMP13 MMP14	1.31e-05	4	52	2	10930399
Pubmed	Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.	UBE2V1 UBE2V2	1.31e-05	4	52	2	10089880
Pubmed	Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo.	MMP13 MMP14	1.31e-05	4	52	2	19010778
Pubmed	The TRAF6 RING finger domain mediates physical interaction with Ubc13.	UBE2V1 UBE2V2	1.31e-05	4	52	2	15147900
Pubmed	PIAS proteins promote SUMO-1 conjugation to STAT1.	PIAS3 PIAS1	1.31e-05	4	52	2	12855578
Pubmed	SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.	PIAS3 PIAS1	1.31e-05	4	52	2	16421255
Pubmed	MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction.	MMP13 MMP14	2.19e-05	5	52	2	22464947
Pubmed	SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.	PIAS3 PIAS1	2.19e-05	5	52	2	21288202
Pubmed	Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.	UBE2V1 UBE2V2	2.19e-05	5	52	2	16129784
Pubmed	Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination.	UBE2V1 UBE2V2	2.19e-05	5	52	2	12039045
Pubmed	PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.	PIAS3 PIAS1	2.19e-05	5	52	2	15907835
Pubmed	Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis.	UBE2V1 UBE2V2	2.19e-05	5	52	2	11406273
Pubmed	SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death.	PIAS3 PIAS1	2.19e-05	5	52	2	28622293
Pubmed	SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-β Responses.	PIAS3 PIAS1	2.19e-05	5	52	2	27703003
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FLNC WARS1 UBE2V1 KMT2A CHD8 EWSR1 CYFIP2 ALG13	2.48e-05	807	52	8	30575818
Pubmed	Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.	FLNC PIAS3 PIAS1	3.23e-05	41	52	3	18157088
Pubmed	Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.	MMP13 MMP14	3.28e-05	6	52	2	10947989
Pubmed	Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner.	PIAS3 PIAS1	3.28e-05	6	52	2	16029420
Pubmed	The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.	UBE2V1 UBE2V2	3.28e-05	6	52	2	16215985
Pubmed	Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.	SENP6 PIAS1	3.28e-05	6	52	2	25557546
Pubmed	Matrix metalloproteinase 14 is required for fibrous tissue expansion.	MMP13 MMP14	3.28e-05	6	52	2	26390284
Pubmed	A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.	PIAS3 PIAS1	3.28e-05	6	52	2	20159969
Pubmed	Contributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones.	MMP13 MMP14	3.28e-05	6	52	2	17136358
Pubmed	Stromal regulation of vessel stability by MMP14 and TGFbeta.	MMP13 MMP14	3.28e-05	6	52	2	20223936
Pubmed	Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes.	CHD8 ALG13	3.28e-05	6	52	2	7505766
Pubmed	Inhibition of Stat1-mediated gene activation by PIAS1.	PIAS3 PIAS1	4.58e-05	7	52	2	9724754
Pubmed	SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.	PIAS3 PIAS1	4.58e-05	7	52	2	31125786
Pubmed	Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.	MMP13 MMP14	4.58e-05	7	52	2	19542530
Pubmed	Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.	TBXT CHD8	4.58e-05	7	52	2	15367660
Pubmed	Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.	PIAS3 PIAS1	4.58e-05	7	52	2	19217413
Pubmed	Human cystathionine beta-synthase is a target for sumoylation.	PIAS3 PIAS1	4.58e-05	7	52	2	17087506
Pubmed	An in situ hybridization study of MMP-2, -9, -13, -14, TIMP-1, and -2 mRNA in fetal mouse mandibular condylar cartilage as compared with limb bud cartilage.	MMP13 MMP14	4.58e-05	7	52	2	30822518
Pubmed	Parallel mechanisms suppress cochlear bone remodeling to protect hearing.	MMP13 MMP14	4.58e-05	7	52	2	27085457
Pubmed	Molecular basis of T cell-mediated recognition of pancreatic cancer cells.	UBE2V1 OAS3	4.58e-05	7	52	2	11280764
Pubmed	Matrix remodeling by MMPs during wound repair.	MMP13 MMP14	4.58e-05	7	52	2	25770908
Pubmed	Site-specific expression of gelatinolytic activity during morphogenesis of the secondary palate in the mouse embryo.	MMP13 MMP14	6.10e-05	8	52	2	23091646
Pubmed	Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.	MMP13 MMP14	6.10e-05	8	52	2	15456762
Pubmed	SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.	PIAS3 SENP6	6.10e-05	8	52	2	37029301
Pubmed	ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.	PIAS3 PIAS1	6.10e-05	8	52	2	11117529
Pubmed	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.	PIAS3 PIAS1	6.10e-05	8	52	2	20351170
Pubmed	Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade.	IL4R NLRP3	6.10e-05	8	52	2	25825216
Pubmed	Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.	PIAS3 PIAS1	6.10e-05	8	52	2	16522640
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF592 NT5E KMT2A CHD8 GPATCH8 PARD3 TAF1L PIAS1 CYFIP2 C6orf132	6.42e-05	1497	52	10	31527615
Pubmed	Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.	PIAS3 PIAS1	7.84e-05	9	52	2	17696781
Pubmed	Detection of gelatinolytic activity in developing basement membranes of the mouse embryo head by combining sensitive in situ zymography with immunolabeling.	MMP13 MMP14	7.84e-05	9	52	2	22688677
Pubmed	CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.	PIAS3 PIAS1	7.84e-05	9	52	2	16679534
Pubmed	A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.	PIAS3 PIAS1	7.84e-05	9	52	2	17533377
Pubmed	A human MAP kinase interactome.	FLNC PIAS3 CHD8 ZNF839 NCKAP5L PIAS1	8.53e-05	486	52	6	20936779
Pubmed	A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity.	PIAS3 PIAS1	9.79e-05	10	52	2	28620180
Pubmed	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.	PIAS3 PIAS1	9.79e-05	10	52	2	18408014
Pubmed	Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.	UBE2V1 UBE2V2	9.79e-05	10	52	2	18678647
Pubmed	Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation.	MMP13 MMP14	1.20e-04	11	52	2	15800063
Pubmed	Basement membrane remodelling regulates mouse embryogenesis.	TBXT MMP14	1.20e-04	11	52	2	32523119
Pubmed	Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.	MMP13 MMP14	1.20e-04	11	52	2	10949161
Pubmed	Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm.	TBXT PARD3	1.20e-04	11	52	2	37080203
Pubmed	TGF-beta3-induced palatogenesis requires matrix metalloproteinases.	MMP13 MMP14	1.20e-04	11	52	2	11359935
Pubmed	SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.	PIAS3 PIAS1	1.20e-04	11	52	2	21965678
Pubmed	Control of Metastases via Myeloid CD39 and NK Cell Effector Function.	NT5E NLRP3	1.20e-04	11	52	2	31992567
Pubmed	Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.	PIAS3 PIAS1	1.20e-04	11	52	2	27009683
Pubmed	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.	PIAS3 PIAS1	1.20e-04	11	52	2	28842558
Pubmed	Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.	PIAS3 PIAS1	1.43e-04	12	52	2	30612578
Pubmed	Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.	MMP13 MMP14	1.43e-04	12	52	2	12149192
Pubmed	Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival.	ALX3 TBXT	1.43e-04	12	52	2	31232685
Pubmed	Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.	TBXT PARD3	1.43e-04	12	52	2	23406901
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZNF592 SENP6 KMT2A ZFPM1 GPATCH8 PARD3 REXO1	1.47e-04	774	52	7	15302935
Pubmed	Foxp1 regulation of neonatal vocalizations via cortical development.	PIAS3 PIAS1	1.69e-04	13	52	2	29138280
Pubmed	Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.	MMP13 MMP14	1.69e-04	13	52	2	15563592
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP13 MMP14	1.69e-04	13	52	2	12815621
Cytoband	1q21-q22	NPR1 SPRR3	3.14e-04	23	52	2	1q21-q22
Cytoband	14q32.31	WARS1 ZNF839	2.65e-03	67	52	2	14q32.31
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2E2 UBE2V1 UBE2V2	7.34e-05	41	36	3	102
GeneFamily	Zinc fingers MIZ-type	PIAS3 PIAS1	8.04e-05	7	36	2	85
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP13 MMP14	1.03e-03	24	36	2	891
Coexpression	PASINI_SUZ12_TARGETS_DN	FLNC NT5E TBXT MMP14 DCBLD2 CYFIP2	3.74e-05	316	52	6	M2293
Coexpression	PASINI_SUZ12_TARGETS_DN	FLNC NT5E TBXT MMP14 DCBLD2 CYFIP2	4.22e-05	323	52	6	MM1066
Coexpression	GSE24671_CTRL_VS_BAKIMULC_INFECTED_MOUSE_SPLENOCYTES_UP	NPC1 SENP6 ZNF839 PIAS1 REXO1	4.78e-05	200	52	5	M9447
Coexpression	GSE14769_UNSTIM_VS_240MIN_LPS_BMDM_DN	UBE2E2 WARS1 OAS3 MMP13 PIAS1	4.78e-05	200	52	5	M3508
Coexpression	GSE5589_LPS_AND_IL10_VS_LPS_AND_IL6_STIM_IL10_KO_MACROPHAGE_45MIN_DN	UBE2V1 SPRR3 ZFPM1 MMP13 DCBLD2	4.78e-05	200	52	5	M6636
Coexpression	GSE3203_WT_VS_IFNAR1_KO_INFLUENZA_INFECTED_LN_BCELL_DN	SEMA3F FLNC NT5E THSD7B C6orf132	4.78e-05	200	52	5	M6798
Coexpression	GSE46606_IRF4_KO_VS_WT_UNSTIM_BCELL_DN	TRPM2 CFP KIF3C MMP14 NLRP3	4.78e-05	200	52	5	M9861
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_200	TGFBI FLNC MYRF	4.10e-05	28	51	3	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_k1_200
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_500	TGFBI FLNC THSD7B MYRF	9.76e-05	100	51	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k2_500
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	TGFBI FLNC THSD7B MMP14 MYRF	1.14e-04	199	51	5	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_1000
CoexpressionAtlas	dev gonad_e11.5_F_GonMes_Sma_k-means-cluster#2_top-relative-expression-ranked_200	TGFBI FLNC MYRF	1.30e-04	41	51	3	gudmap_dev gonad_e11.5_F_GonMes_Sma_k2_200
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000	TGFBI FLNC KALRN THSD7B MMP14 MYRF	1.51e-04	337	51	6	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_500	TGFBI FLNC THSD7B MYRF	1.73e-04	116	51	4	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k3_500
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	TGFBI FLNC KALRN THSD7B MMP14 MYRF	1.97e-04	354	51	6	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_1000
CoexpressionAtlas	Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4	TGFBI TRPM2 CFP MMP13 MMP14 NLRP3	2.29e-04	364	51	6	GSM854276_500
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4	TGFBI TRPM2 CFP MMP13 MMP14 NLRP3	2.43e-04	368	51	6	GSM854258_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	TGFBI FLNC KALRN THSD7B MYRF	2.72e-04	240	51	5	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k1_1000
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7	TGFBI TRPM2 CFP MMP13 MMP14 NLRP3	2.92e-04	381	51	6	GSM854262_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000	TGFBI FLNC THSD7B MMP14 MYRF	4.29e-04	265	51	5	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
CoexpressionAtlas	Myeloid Cells, GN.UrAc.PC, CD11b+ Ly6-G+, Peritoneal Cavity, avg-3	TGFBI TRPM2 OAS3 CFP IL4R NLRP3	4.32e-04	410	51	6	GSM854312_500
CoexpressionAtlas	Myeloid Cells, GN.BM, CD11b+ Ly6-G+, Bone marrow, avg-4	TGFBI NT5E TRPM2 OAS3 CFP NLRP3	4.60e-04	415	51	6	GSM605846_500
CoexpressionAtlas	Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4	TGFBI MMP13 MMP14	4.68e-04	63	51	3	GSM854258_100
CoexpressionAtlas	Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3	TGFBI NT5E TRPM2 OAS3 CFP NLRP3	4.78e-04	418	51	6	GSM854338_500
CoexpressionAtlas	Myeloid Cells, GN.Arth.BM, CD11b+ Ly6-G+, Bone marrow, avg-3	TGFBI NT5E TRPM2 OAS3 CFP NLRP3	4.90e-04	420	51	6	GSM854303_500
CoexpressionAtlas	Myeloid Cells, DC.11cloSer.SI, CD45+ MHCII+ CD11c-lo CD11b+, Small Intestine, avg-5	TGFBI MMP13 NLRP3	4.90e-04	64	51	3	GSM854280_100
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBI WARS1 OAS3 CFP NLRP3	3.36e-06	197	52	5	383d598ce3f8f5fc98bef3300e4cf7b6992aec9c
ToppCell	COVID-19_Moderate-Classical_Monocyte\|World / disease group, cell group and cell class	TGFBI WARS1 OAS3 CFP NLRP3	3.36e-06	197	52	5	16cf3939e700aef1e16159f0652ba2dfad287e7a
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TGFBI WARS1 OAS3 CFP NLRP3	3.36e-06	197	52	5	3cc4e56a77f96a43f9b5a24cf1b9524c927ef795
ToppCell	control-CD163+_Monocytes_(Sample_ID1_d7)\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TGFBI WARS1 OAS3 CFP NLRP3	3.53e-06	199	52	5	933201d32eda12a89660bdbae9114a95cc428a38
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEU4 UBE2V1 ZNF592 OAS3	3.31e-05	156	52	4	abea3c183d32062b009a79a2bdf861021989c7ef
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	3.48e-05	158	52	4	e0b862e4b9ebaa12869640b5d18d5fa852861bef
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI CFP MMP13 NLRP3	3.74e-05	161	52	4	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI CFP MMP13 NLRP3	3.74e-05	161	52	4	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI CFP MMP13 NLRP3	3.74e-05	161	52	4	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	3.83e-05	162	52	4	59147406c28b7cdf43a1815f99c15c2bd6ae8fa3
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	3.83e-05	162	52	4	8e0bcc23c3086fc4b0c9dbeec13a7edaf6b83750
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	3.83e-05	162	52	4	736fdcbd0f7d50fc297f13d36ab4c0dc82ad509c
ToppCell	droplet-Fat-Gat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	4.12e-05	165	52	4	c3ca2b35299294a5e3d1881fd11617e3ab720692
ToppCell	droplet-Fat-Gat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP NLRP3	4.12e-05	165	52	4	af32eae9324ef053f4f76e2144fb84c6e264c482
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI UBE2E2 TRPM2 CFP	4.52e-05	169	52	4	3f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI UBE2E2 TRPM2 CFP	4.52e-05	169	52	4	26de495c7562e0740689d0f78e803698e3e793db
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TGFBI CFP MMP13 NLRP3	4.52e-05	169	52	4	8180aeda13c511260d0542a94156059d558848a7
ToppCell	facs-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI OAS3 CFP NLRP3	4.52e-05	169	52	4	05b138511039f1255a5f647040b1b9bdf222bd52
ToppCell	facs-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI OAS3 CFP NLRP3	4.52e-05	169	52	4	bf0a97f53d6e3f9ffeaeae0402b010c49a6cccb7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNC KALRN NT5E KIF3C	4.62e-05	170	52	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNC KALRN NT5E KIF3C	4.62e-05	170	52	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	facs-BAT-Fat-3m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM2 OAS3 CFP NLRP3	4.62e-05	170	52	4	8fd0a55266066a51266ab616c38c883e2680bcf4
ToppCell	droplet-Spleen-SPLEEN-1m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI UBE2E2 TRPM2 CFP	4.62e-05	170	52	4	670027daec5a10dfa12246f1497b58db21d32a22
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNC KALRN NT5E KIF3C	4.62e-05	170	52	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI UBE2E2 TRPM2 CFP	4.73e-05	171	52	4	5b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 OAS3 MMP13	4.73e-05	171	52	4	d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRPM2 CFP TAF1L NLRP3	4.84e-05	172	52	4	cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 OAS3 CFP	5.06e-05	174	52	4	3533a47885af453d97739e5576e989d93d31be32
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 OAS3 CFP	5.06e-05	174	52	4	b487c5c46f074a69b9526a2c72daf218f66aa44b
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	NPC1 TGFBI DCBLD2 NLRP3	5.41e-05	177	52	4	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TGFBI TRPM2 CFP MMP13	5.53e-05	178	52	4	6c1b5087581ca8cea976d89ea6f34088c8fc3668
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	THSD7B MMP13 MMP14 MYRF	5.65e-05	179	52	4	98c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	5.77e-05	180	52	4	2bc3fd2e4c249bf236340c5f0483747faa5c04ec
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	TGFBI WARS1 CFP NLRP3	5.90e-05	181	52	4	921e917f83105896ad8918dc134b871708024021
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLNC KALRN NT5E CNKSR3	5.90e-05	181	52	4	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	5.90e-05	181	52	4	1b4eb044825ede6361928442524b1988c8ef58b3
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLNC KALRN NT5E CNKSR3	5.90e-05	181	52	4	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Dendritic\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	5.90e-05	181	52	4	8d7ebbedc373d55e29da02ac2728b4f4118038f2
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBI NEU4 ZFPM1 REXO1	6.03e-05	182	52	4	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBI NEU4 ZFPM1 REXO1	6.03e-05	182	52	4	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TGFBI NEU4 ZFPM1 REXO1	6.03e-05	182	52	4	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBI WARS1 CFP NLRP3	6.16e-05	183	52	4	4763df29c888d47c22076803b054f06b4cc29368
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TGFBI WARS1 CFP NLRP3	6.16e-05	183	52	4	fcb0f755382d88fb207fc2322cd224c09c6e2ea6
ToppCell	normal_Lymph_Node-Myeloid_cells-Monocytes\|normal_Lymph_Node / Location, Cell class and cell subclass	TGFBI WARS1 CFP NLRP3	6.29e-05	184	52	4	3cec28ff076fa53d034428de2bb1a237e0c1568c
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPC1 TGFBI TRPM2 MMP14	6.42e-05	185	52	4	29d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPC1 TGFBI TRPM2 MMP14	6.42e-05	185	52	4	780bdb63ef913a09930063286011c9108381d3a9
ToppCell	Endothelial-B-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	FLNC KALRN NT5E CNKSR3	6.42e-05	185	52	4	133c9dc64d564dae4aeeeca22f386aa3f13fa980
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NPC1 TGFBI TRPM2 MMP14	6.42e-05	185	52	4	274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCell	BAL-Control-Myeloid-MoAM-MoAM4-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NPC1 TGFBI TRPM2 MMP14	6.42e-05	185	52	4	b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	6.69e-05	187	52	4	03de3c2df31bca0dc4e3718bada708d8fe8b69b9
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	FLNC KALRN CNKSR3 KIF3C	6.69e-05	187	52	4	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NPC1 PARD3 MYRF C6orf132	6.83e-05	188	52	4	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	ASK428-Endothelial-Lymphatic\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	FLNC NT5E CNKSR3 KIF3C	6.83e-05	188	52	4	c371bc340966cfe9205cbf4b62c6452f49f2559f
ToppCell	Control-Myeloid-MoAM1\|Control / Disease group,lineage and cell class （2021.01.30）	NPC1 TGFBI TRPM2 MMP14	6.98e-05	189	52	4	55d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCell	COVID-19-lung-Lymphatic_EC\|lung / Disease (COVID-19 only), tissue and cell type	FLNC KALRN CNKSR3 KIF3C	6.98e-05	189	52	4	c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NPC1 TGFBI TRPM2 MMP14	6.98e-05	189	52	4	ebb5e069fdca7cf8ffac16a57572e92d2593c86a
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NPC1 TGFBI TRPM2 MMP14	6.98e-05	189	52	4	a59e4eaff430a443f9fa7edabe64e66a15b6bffb
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPC1 TGFBI TRPM2 MMP14	7.12e-05	190	52	4	5c8aa310886c64ee5dce4ba46a3dd178da549529
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3F KALRN CNKSR3 IL4R	7.12e-05	190	52	4	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPC1 TGFBI TRPM2 MMP14	7.12e-05	190	52	4	4b4fe93061c87605dddf5bec94fa07c749c722aa
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.27e-05	191	52	4	54029b68fb78163c969890886ab0f8fb0dcf3c20
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-3\|TCGA-Ovary / Sample_Type by Project: Shred V9	TGFBI NT5E MMP13 IL4R	7.27e-05	191	52	4	80d30d8eedb4c70b58440646325bc04c5700803e
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TGFBI WARS1 OAS3 NLRP3	7.41e-05	192	52	4	f14ee74ac3275601749a23c5efe39c2413a62e1a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	NPC1 TGFBI IL4R C6orf132	7.41e-05	192	52	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI PIAS3 CFP ZFPM1	7.41e-05	192	52	4	af453a179f3fdd4ae870f1d98a485e8c9fd726ac
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI PIAS3 CFP ZFPM1	7.41e-05	192	52	4	176b9c1dd2c91bca46e12fa5060bfe590dc18246
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI PIAS3 CFP ZFPM1	7.41e-05	192	52	4	81f93b4c853f176c91b5ddef34238e37047a0e69
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	NPC1 TGFBI TRPM2 MMP14	7.41e-05	192	52	4	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBI WARS1 OAS3 NLRP3	7.41e-05	192	52	4	0219093e7921a0db78053aee13ec480b520f5662
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.56e-05	193	52	4	4f38aae346ea3b4258744e9dc1e5aeb4fea13d06
ToppCell	PCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.56e-05	193	52	4	72128ece598070f8e752a0691e024e26ab364989
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI CFP MMP14 NLRP3	7.56e-05	193	52	4	d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	7.56e-05	193	52	4	69352551ad5db325ac0d6df2ac1e35ae473ac01f
ToppCell	CF-Myeloid-Monocyte\|CF / Disease state, Lineage and Cell class	TGFBI UBE2E2 WARS1 NLRP3	7.56e-05	193	52	4	3a83b2593a37a075f91354745e5a7a081ec406a8
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.72e-05	194	52	4	2e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SEMA3F NPR1 CFP THSD7B	7.72e-05	194	52	4	efd5efed060edb7f24d59600981bb60ec28ac2ef
ToppCell	medial-2-Hematologic-EREG+_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFBI NEU4 CFP NLRP3	7.72e-05	194	52	4	b2b4e4c3ac0df0d9f17b930ffb60c0fd85b3dd78
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FLNC KALRN NT5E CNKSR3	7.72e-05	194	52	4	f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FLNC KALRN NT5E CNKSR3	7.72e-05	194	52	4	3b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCell	medial-Hematologic-EREG+_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFBI NEU4 CFP NLRP3	7.72e-05	194	52	4	15f3b6b6579e388d0820f05e93a77ee1634bd6c3
ToppCell	medial-Hematologic-EREG+_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFBI NEU4 CFP NLRP3	7.72e-05	194	52	4	1f3d22292d2691f93aa7b6770f5c250a33db3cc0
ToppCell	PCW_05-06-Endothelial-Endothelial_immature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.72e-05	194	52	4	9bd25ea57f2da27bd200d1a8bf797fec77d172c7
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FLNC KALRN NT5E CNKSR3	7.72e-05	194	52	4	5d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	7.87e-05	195	52	4	9f7dc9328d244291baf92b03c346c2189b58e7c4
ToppCell	control-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TGFBI WARS1 OAS3 CFP	7.87e-05	195	52	4	19413dc6aa0010686cdfa0c750ef0a7a76caf308
ToppCell	PCW_05-06-Endothelial-Endothelial_mature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.87e-05	195	52	4	54fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3F KALRN CNKSR3 IL4R	7.87e-05	195	52	4	fde8e7b38b3631109b95ef111c5f6e3f9878cfbd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3F WARS1 KALRN IL4R	7.87e-05	195	52	4	818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NPR1 NT5E CFP THSD7B	7.87e-05	195	52	4	ca2cf2c10db1ad17aa0a2e30aa7079a7ad751ea6
ToppCell	distal-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC NT5E CNKSR3 KIF3C	7.87e-05	195	52	4	8e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TGFBI UBE2E2 OAS3 CFP	7.87e-05	195	52	4	dd28c63b53f2a97e3fac127294a465870dc371b3
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFBI UBE2E2 OAS3 CFP	7.87e-05	195	52	4	d6ff38535898f90be6719cd5152291f2f4f8a746
ToppCell	normal_Lymph_Node-Myeloid_cells-CD1c+_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	TGFBI WARS1 CFP NLRP3	7.87e-05	195	52	4	cd4d61a463e0e87b711e08ceedee5bef5d735e64
ToppCell	distal-Hematologic-EREG+_Dendritic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFBI TRPM2 CFP NLRP3	8.03e-05	196	52	4	c17bb7b3992bfec194bfa310f201a5c64b35868e
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	8.03e-05	196	52	4	1d170422a9eb5e477ce837f9da1c7db95ee5da1c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Classical_Monocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBI WARS1 CFP NLRP3	8.03e-05	196	52	4	76101d5ebe2a74c0a0a885ec31c3c1847bda8a7b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3F WARS1 KALRN IL4R	8.03e-05	196	52	4	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	Monocytes-IL1B+_Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	TGFBI TRPM2 CFP NLRP3	8.03e-05	196	52	4	7bc0735d324ac5a1661434cda4116ddd58296730
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SEMA3F WARS1 KALRN IL4R	8.03e-05	196	52	4	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	ILEUM-inflamed-(3)_Inf._Macrophages\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TGFBI WARS1 MMP14 NLRP3	8.03e-05	196	52	4	6ba84bc229e80b4e71c59301154d165066dd618c
Drug	Urosiol [128-13-2]; Down 200; 10.2uM; PC3; HT_HG-U133A	EPHB3 SEMA3F NFATC3 TRPM2 OAS3 KIF3C IL4R ALG13	1.54e-08	198	52	8	7243_DN
Drug	sulindac; Down 200; 100uM; MCF7; HG-U133A	TGFBI NFATC3 KMT2A TBXT KIF3C GPATCH8 MYRF	3.14e-07	197	52	7	168_DN
Drug	isodonin	NT5E NLRP3	5.12e-06	2	52	2	CID000073075
Drug	lead aspartate	NT5E ZFPM1	5.12e-06	2	52	2	CID000203363
Drug	Homatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A	SEMA3F KMT2A GPATCH8 MMP13 MMP14 IL4R	5.68e-06	197	52	6	1806_DN
Drug	(-)-quinpirole hydrochloride; Down 200; 1uM; MCF7; HG-U133A	EPHB3 TRPM2 OAS3 TBXT PARD3 ZNF839	6.02e-06	199	52	6	456_DN
Drug	1,1-dimethylbiguanide hydrochloride; Down 200; 1000uM; MCF7; HG-U133A	SEMA3F KMT2A OAS3 TBXT PARD3 ZNF839	6.02e-06	199	52	6	4_DN
Drug	silver;bromide	NT5E ZFPM1	5.09e-05	5	52	2	CID009881822
Drug	SAHA; Down 200; 10uM; PC3; HT_HG-U133A	TRPM2 SENP6 ZNF839 MMP14 IL4R	5.33e-05	178	52	5	4444_DN
Drug	glutaraldehyde	NEU4 WARS1 KMT2A MMP13	6.34e-05	94	52	4	CID000003485
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; HL60; HT_HG-U133A	PIAS3 KIF3C ZNF839 IL4R NLRP3	7.44e-05	191	52	5	2937_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; HL60; HT_HG-U133A	SEMA3F CFP KIF3C MYRF NLRP3	7.63e-05	192	52	5	1337_UP
Drug	Prednicarbate [73771-04-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	EPHB3 SENP6 KMT2A ZNF839 MMP14	7.82e-05	193	52	5	5119_DN
Drug	Lynestrenol [52-76-6]; Up 200; 14uM; MCF7; HT_HG-U133A	SEMA3F KALRN TRPM2 OAS3 KIF3C	8.01e-05	194	52	5	5355_UP
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A	EPHB3 SEMA3F NPR1 NFATC3 ZNF839	8.01e-05	194	52	5	7000_UP
Drug	Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	SEMA3F NPR1 KMT2A KIF3C MMP14	8.21e-05	195	52	5	7434_UP
Drug	Retrorsine [480-54-6]; Down 200; 11.4uM; PC3; HT_HG-U133A	EPHB3 SENP6 ZNF839 MMP14 MYRF	8.41e-05	196	52	5	6601_DN
Drug	Rolitetracycline [751-97-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A	SPRR3 TRPM2 TBXT PARD3 DCBLD2	8.41e-05	196	52	5	3369_UP
Drug	Fluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; PC3; HT_HG-U133A	EPHB3 SENP6 OAS3 MMP13 MMP14	8.41e-05	196	52	5	6757_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	SEMA3F SENP6 MMP14 MYRF ALG13	8.41e-05	196	52	5	5979_UP
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; PC3; HT_HG-U133A	EPHB3 NFATC3 CHD8 ZNF839 MMP14	8.61e-05	197	52	5	4604_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; PC3; HT_HG-U133A	SEMA3F WARS1 ZNF839 MMP14 CYFIP2	8.61e-05	197	52	5	1803_DN
Drug	Pempidine tartrate [546-48-5]; Up 200; 13uM; MCF7; HT_HG-U133A	NPR1 KMT2A MMP14 MYRF NLRP3	8.61e-05	197	52	5	3832_UP
Drug	Metyrapone [54-36-4]; Down 200; 17.6uM; PC3; HT_HG-U133A	NFATC3 TRPM2 EWSR1 ZNF839 MMP14	8.61e-05	197	52	5	4606_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Up 200; 9uM; PC3; HT_HG-U133A	SEMA3F NPR1 NFATC3 MMP13 MMP14	8.61e-05	197	52	5	5787_UP
Drug	Cefmetazole sodium salt [56796-39-5]; Up 200; 8.2uM; PC3; HT_HG-U133A	SEMA3F NFATC3 SENP6 TBXT MYRF	8.82e-05	198	52	5	5868_UP
Drug	Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ZNF592 SENP6 KIF3C ZNF839 IL4R	8.82e-05	198	52	5	7008_UP
Drug	U-62066 [87151-85-7]; Down 200; 1uM; MCF7; HT_HG-U133A	SEMA3F NPR1 TRPM2 KMT2A KIF3C	9.03e-05	199	52	5	4375_DN
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; PC3; HT_HG-U133A	NFATC3 SENP6 MMP14 MYRF IL4R	9.25e-05	200	52	5	6628_DN
Drug	Amidopyrine [58-15-1]; Up 200; 17.2uM; PC3; HT_HG-U133A	TGFBI NPR1 NFATC3 KMT2A MMP14	9.25e-05	200	52	5	4481_UP
Drug	HS 142-1	NPR1 NFATC3	1.07e-04	7	52	2	ctd:C072551
Drug	Raloxifene Hydrochloride	TGFBI SEMA3F FLNC PIAS3 TBXT KIF3C DCBLD2 IL4R NLRP3	1.25e-04	857	52	9	ctd:D020849
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	TBXT PARD3	8.47e-05	8	52	2	C3891448
Disease	Small cell carcinoma of lung	EPHB3 KMT2A TAF1L	1.20e-04	54	52	3	C0149925
Disease	hematologic cancer (implicated_via_orthology)	PIAS3 PIAS1	2.35e-04	13	52	2	DOID:2531 (implicated_via_orthology)
Disease	asthma	UBE2E2 CNKSR3 TBXT ZKSCAN2 MYRF IL4R CYFIP2	3.33e-04	751	52	7	MONDO_0004979
Disease	Manic	ZNF592 TRPM2 DNAH8	3.58e-04	78	52	3	C0338831
Disease	hemoglobin change measurement	CNKSR3 KMT2A	6.88e-04	22	52	2	EFO_0600027
Disease	Prostatic Neoplasms	SENP6 KMT2A EWSR1 PARD3 MMP13 TAF1L	7.28e-04	616	52	6	C0033578
Disease	Malignant neoplasm of prostate	SENP6 KMT2A EWSR1 PARD3 MMP13 TAF1L	7.28e-04	616	52	6	C0376358
Disease	unipolar depression, depressive symptom measurement	KMT2A ZKSCAN2	9.64e-04	26	52	2	EFO_0003761, EFO_0007006
Disease	major depressive disorder, COVID-19	OAS3 ZKSCAN2	9.64e-04	26	52	2	MONDO_0002009, MONDO_0100096
Disease	severe acute respiratory syndrome, COVID-19	UBE2E2 CNKSR3 TRPM2 PARD3 REXO1	1.13e-03	447	52	5	EFO_0000694, MONDO_0100096
Disease	cerebral infarction (is_implicated_in)	KALRN MYRF	1.20e-03	29	52	2	DOID:3526 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGYEKVPGEKGCPAA	TGFBI	86	Q15582
NQCKAPKPEGFLPPP	EWSR1	541	Q01844
CEDPEYKPLQGPPKD	CHD8	1691	Q9HCK8
PGPKVDFYPGPGKRC	ALG13	671	Q9NP73
NCPGPKLEKPGEEYS	ANTXRL	311	A6NF34
KPPAKYLQDLGPGPA	ALX3	66	O95076
GYPPPDIPKCGFDNE	NPR1	446	P16066
PDKPKNPTYGPNICD	MMP14	306	P50281
PLQGCGKPPGKPSSE	NCKAP5L	1076	Q9HCH0
FPLPDGKYSLPTKCP	MCM8	251	Q9UJA3
RKKAVSAPPGYPEGP	KIF3C	411	O14782
PKLKDPPQGYFGPKL	GPATCH8	1121	Q9UKJ3
YGPGDEDPNPKHPKT	MMP13	266	P45452
GGAALDLKACPPKPY	DNAH8	3786	Q96JB1
GVLPPDPSKVCAYGP	FLNC	1056	Q14315
KKYSCPAAPPPGALG	ZFPM1	836	Q8IX07
AGSEKPPKGSSYNPP	KALRN	2271	O60229
PCPPGSYKAKQGEGP	EPHB3	286	P54753
PRPGYKPQEPNGCGS	PLA2G12B	76	Q9BX93
QKPPGKPCPGLAYEQ	CFP	231	P27918
PPNDPCLRGEKDPKG	CYFIP2	526	Q96F07
ASPKPPNLGDKPRGC	NEU4	466	Q8WWR8
NCEYSGPPKPLPKDG	NPC1	41	O15118
GPPKPLPKDGYDLVQ	NPC1	46	O15118
PKTSPGGGEVPCLYK	C6orf132	756	Q5T0Z8
YKPFQDLIPGCPGDP	IL4R	631	P24394
HPECLGPNYPTKPTK	KMT2A	1506	Q03164
QYDTPKAGKPGLPAP	DCBLD2	731	Q96PD2
KCNELKSPGSPPGPE	PARD3	686	Q8TEW0
NKGKGPAPASLPPAY	OAS3	616	Q9Y6K5
DYPPQKGCIPLPRGQ	NLRP3	31	Q96P20
EDYKADCPPGNPAPT	WARS1	56	P23381
EPYTPAPKKLCDPFG	REXO1	266	Q8N1G1
PERLESGKGKCPYDP	SEMA3F	191	Q13275
KPGKDPGAPDCKYGE	TAF1L	726	Q8IZX4
KPCSLPGYLPPTKNG	PIAS1	226	O75925
PGCTKVPEPGYTKVP	SPRR3	96	Q9UBC9
GNPPSKEVPAGKYPF	NT5E	251	P21589
CKQPLPGPKGSESPN	CNK3/IPCEF1	371	G9CGD6
CKQPLPGPKGSESPN	CNKSR3	371	Q6P9H4
NGKLCPLPGYLPPTK	PIAS3	216	Q9Y6X2
KKEASEVCPPPGYGL	PIAS3	411	Q9Y6X2
PPPNCSAGPKGDNIY	UBE2E2	71	Q96LR5
CSPNGTDPYKPKCPE	TRPM2	996	O94759
KPKHSDSYFPPPLGC	ZNF592	161	Q92610
SLKIECGPKYPEAPP	UBE2V1	66	Q13404
KYSPLGGPKPFECPS	NFATC3	96	Q12968
VCFPGLEKPKYEPNP	SENP6	771	Q9GZR1
PGGKPEPQAPSCVYI	TBXT	111	O15178
KYAPPPCGGPEDVAL	SNHG28	56	P0DPA3
DCAYRTVPKPGPQPG	ZNF839	696	A8K0R7
KVECGPKYPEAPPSV	UBE2V2	66	Q15819
PPSLYCPENPHKGKT	ZKSCAN2	946	Q63HK3
PYNGGRPCPKLDLKN	THSD7B	1031	Q9C0I4
GGTGPPIKAEPKAPY	MYRF	116	Q9Y2G1