Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainDVL-1

DVL1P1 DVL1

1.45e-062232IPR008340
DomainDishevelled_protein_dom

DVL1P1 DVL1

8.69e-064232IPR003351
DomainDishevelled

DVL1P1 DVL1

8.69e-064232PF02377
DomainDishevelled_fam

DVL1P1 DVL1

8.69e-064232IPR008339
DomainDIX

DVL1P1 DVL1

3.03e-057232IPR001158
DomainDIX

DVL1P1 DVL1

3.03e-057232PS50841
DomainDAX

DVL1P1 DVL1

3.03e-057232SM00021
DomainDIX

DVL1P1 DVL1

3.03e-057232PF00778
DomainDEP

DVL1P1 DVL1

3.30e-0422232SM00049
DomainDEP

DVL1P1 DVL1

3.30e-0422232PF00610
DomainDEP

DVL1P1 DVL1

3.30e-0422232PS50186
DomainDEP_dom

DVL1P1 DVL1

3.61e-0423232IPR000591
DomainHECT

SMURF2 HERC5

5.00e-0427232PF00632
DomainHECTc

SMURF2 HERC5

5.00e-0427232SM00119
DomainHECT_dom

SMURF2 HERC5

5.00e-0427232IPR000569
DomainHECT

SMURF2 HERC5

5.00e-0427232PS50237
DomainPDZ

GRIP2 DVL1P1 DVL1

6.68e-04141233PF00595
DomainPDZ

GRIP2 DVL1P1 DVL1

7.69e-04148233SM00228
DomainPDZ

GRIP2 DVL1P1 DVL1

8.15e-04151233PS50106
DomainPDZ

GRIP2 DVL1P1 DVL1

8.30e-04152233IPR001478
Domain-

GRIP2 DVL1

1.45e-021502322.30.42.10
Domainfn3

RIMBP2 MYOM3

1.68e-02162232PF00041
Pubmed

Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.

DVL1P1 DVL1

4.18e-0722328644734
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

ARL6IP4 MGA CACTIN LUC7L2

5.04e-079823434943047
Pubmed

Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.

DVL1P1 DVL1

2.51e-06423220639201
Pubmed

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

DVL1P1 DVL1

2.51e-0642328817329
Pubmed

Human dishevelled genes constitute a DHR-containing multigene family.

DVL1P1 DVL1

2.51e-0642329192851
Pubmed

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).

DVL1P1 DVL1

1.17e-05823219643732
Pubmed

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

ZBTB47 ATP8B2 SLC45A4

1.72e-057623310574461
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

SMURF2 DVL1

1.24e-042523219379695
Pubmed

Placental PPARĪ³ regulates spatiotemporally diverse genes and a unique metabolic network.

PPARGC1A RND2 SLC45A4

1.70e-0416423322967998
Pubmed

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.

TRA2A LUC7L2 DVL1

3.18e-0420323335012549
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

ARL6IP4 TRA2A LUC7L2

5.71e-0424823327926873
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

ARL6IP4 TRA2A LUC7L2

6.47e-0425923330404004
InteractionCFH interactions

ARL6IP4 MGA CACTIN LUC7L2

1.78e-05140234int:CFH
InteractionNKAPD1 interactions

ARL6IP4 TRA2A CACTIN LLGL2

3.09e-05161234int:NKAPD1
InteractionARHGAP5 interactions

MGA SMURF2 RND2

4.93e-0563233int:ARHGAP5
GeneFamilyPDZ domain containing

GRIP2 DVL1

6.86e-031521521220
GeneFamilyRNA binding motif containing

TRA2A PPARGC1A

1.31e-02213152725
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZBTB47 USHBP1 RIMBP2

8.27e-051662336d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

PPARGC1A LLGL2 DVL1

9.67e-05175233bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

PPARGC1A RIMBP2 LLGL2

9.84e-0517623336f77d878a53b30465b0dea8333a3865dba75613
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

USHBP1 PPARGC1A RIMBP2

1.00e-0417723399500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPARGC1A ANO7 LLGL2

1.12e-04184233936b39377eebea3961d702532779f6cd27953be7
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPARGC1A ANO7 LLGL2

1.12e-04184233886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPARGC1A RIMBP2 LLGL2

1.18e-041872337ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.20e-041882336d249fe92d51a19da19ec14bb2262d394255d577
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ZBTB47 USHBP1 ATP8B2

1.20e-04188233c90669b51e1902fe7726555290c91c92a911df83
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.20e-041882330758b474457efa36488e0195f7357100f4b6a090
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPARGC1A RIMBP2 LLGL2

1.21e-04189233f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIMBP2 LLGL2 MYOM3

1.21e-041892335d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.21e-041892339c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.23e-04190233de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.23e-04190233fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.25e-041912335d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

PPARGC1A GRIP2 MYOM3

1.25e-0419123325f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIMBP2 RND2 LLGL2

1.29e-04193233ab78fb1603ea6f720ba2d30148fe65dccf271fe1
DiseaseDiGeorge syndrome (is_implicated_in)

DVL1P1 DVL1

4.82e-065212DOID:11198 (is_implicated_in)
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

USHBP1 DVL1P1 DVL1

6.71e-0652213EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Diseasenephrotic syndrome (biomarker_via_orthology)

PPARGC1A NPHS2

1.32e-0424212DOID:1184 (biomarker_via_orthology)
Diseasemyocardial infarction (biomarker_via_orthology)

PPARGC1A DVL1P1 DVL1

1.94e-04160213DOID:5844 (biomarker_via_orthology)
Diseasenicotine dependence

DVL1P1 DVL1

1.40e-0378212EFO_0003768
Diseaseneurodegenerative disease (implicated_via_orthology)

DVL1P1 DVL1

4.74e-03145212DOID:1289 (implicated_via_orthology)
DiseaseFEV/FEC ratio

MGA PPARGC1A SMURF2 LLGL2

1.01e-021228214EFO_0004713
Diseasediastolic blood pressure, systolic blood pressure

USHBP1 PPARGC1A SLC45A4

1.14e-02670213EFO_0006335, EFO_0006336
DiseaseAbnormality of refraction

PPARGC1A RIMBP2 SLC45A4

1.16e-02673213HP_0000539

Protein segments in the cluster

PeptideGeneStartEntry
MSARATRPRSRRGRH

USHBP1

1

Q8N6Y0
QHRCMRRVGRTGSRR

ATP8B2

1131

P98198
SGSHCARSRMLRRRA

ANO7

46

Q6IWH7
RQSFRRMRRSRVSSR

LLGL2

651

Q6P1M3
RMRRSRVSSRKRHPA

LLGL2

656

Q6P1M3
RTHTANERRRRGEMR

MGA

2426

Q8IWI9
MERRARSSSRESRGR

NPHS2

1

Q9NP85
RINSRAHARTRARSR

GABRE

381

P78334
MERRSRRKSRRNGRS

HERC5

1

Q9UII4
RPQRMRSRSRSFSRH

PPARGC1A

561

Q9UBK2
MSGHQRTRSRSRERR

PAGE3

1

Q5JUK9
MAHVGSRKRSRSRSR

ARL6IP4

1

Q66PJ3
MGRDTRSRSRSAGRR

CACTIN

1

Q8WUQ7
GTESMVSHRRERARR

DVL1

136

O14640
GTESMVSHRRDRARR

DVL1P1

136

P54792
TMGRRRQRRREHKSS

GRIP2

421

Q9C0E4
SRSREHRRHRSRSMS

LUC7L2

271

Q9Y383
HRRHRSRSMSRERKR

LUC7L2

276

Q9Y383
ERSRRSGRRHSVSTR

RIMBP2

941

O15034
SATSSSMRRRRHAFR

SLC45A4

406

Q5BKX6
SMRRRRHAFRRQASS

SLC45A4

411

Q5BKX6
RRVRSQRHRNYMSRT

SMURF2

231

Q9HAU4
HRQLRRTDSRRGMQR

RND2

186

P52198
YRRRRSRSHSPMSNR

TRA2A

91

Q13595
HMATRSRENARRRGT

ZBTB47

376

Q9UFB7
RQHSLRMGSSVRRRT

MYOM3

36

Q5VTT5
RMGSSVRRRTFRSSE

MYOM3

41

Q5VTT5