Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 ADGRG7 OR51F2 TAS2R16 TAS2R8 ADRA1A OR4A8 ADGRG2 OR4A5 GPR158 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 ADGRD2 OR4D5 GNRHR

5.79e-1288414429GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 TLR6 PTGER2 OR6M1 OR6N1 CHRNG ADGRG7 OR51F2 TAS2R16 TAS2R8 ADRA1A OR4A8 ADGRG2 OR4A5 GPR158 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 ADGRD2 OR4D5 GNRHR GABRR3

1.75e-09135314432GO:0004888
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC43A2 CACNA1D CACNA1F SLC9A8 SLC29A3 SLC22A25 TRPC4AP SLC4A7 SLC4A8 ABCC5 SLC35B2 ABCC6 GJD4 CHRNG ITPR1 ITPR2 ITPR3 GJA1 SLC7A4 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ABCC12 ANO3 KCNT1 GABRR3

5.03e-09118014429GO:0022857
GeneOntologyMolecularFunctionolfactory receptor activity

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

1.47e-0843114417GO:0004984
GeneOntologyMolecularFunctiontransporter activity

SLC43A2 CACNA1D CACNA1F SLC9A8 SLC29A3 SLC22A25 TRPC4AP SLC4A7 SLC4A8 ABCC5 SLC35B2 ABCC6 GJD4 CHRNG ITPR1 ITPR2 ITPR3 GJA1 SLC7A4 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ABCC12 ANO3 KCNT1 GABRR3

3.54e-08128914429GO:0005215
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR1 ITPR2 ITPR3

3.67e-0731443GO:0005220
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 ABCC5 ABCC6 ITPR1 ITPR2 ITPR3 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ANO3 KCNT1 GABRR3

5.44e-0775814420GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CHRNG ITPR1 ITPR2 ITPR3 GJA1 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ANO3 KCNT1 GABRR3

1.10e-0679314420GO:0015075
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 ITPR1 ITPR2 ITPR3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

1.40e-0646514415GO:0046873
GeneOntologyMolecularFunctionchannel activity

CACNA1D CACNA1F TRPC4AP GJD4 CHRNG ITPR1 ITPR2 ITPR3 GJA1 SCN5A SCN10A TRPM8 ANO3 KCNT1 GABRR3

6.16e-0652514415GO:0015267
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CHRNG ITPR1 ITPR2 ITPR3 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

6.17e-0666414417GO:0008324
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1D CACNA1F TRPC4AP GJD4 CHRNG ITPR1 ITPR2 ITPR3 GJA1 SCN5A SCN10A TRPM8 ANO3 KCNT1 GABRR3

6.30e-0652614415GO:0022803
GeneOntologyMolecularFunctionsodium:bicarbonate symporter activity

SLC4A7 SLC4A8 SLC4A10

7.23e-0661443GO:0008510
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 ITPR1 ITPR2 ITPR3 SLC45A3 SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

1.23e-0562714416GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1D CACNA1F TRPC4AP CHRNG ITPR1 ITPR2 ITPR3 SCN5A SCN10A TRPM8 ANO3 KCNT1 GABRR3

2.89e-0545914413GO:0005216
GeneOntologyMolecularFunctiongated channel activity

CACNA1D CACNA1F CHRNG ITPR1 ITPR2 ITPR3 SCN10A TRPM8 ANO3 KCNT1 GABRR3

3.15e-0533414411GO:0022836
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC4A7 SLC4A8 ABCC5 ABCC6 SLC17A1 SLC4A10 ANO3 GABRR3

3.44e-051711448GO:0015103
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1D CACNA1F TRPC4AP CHRNG ITPR1 ITPR2 ITPR3 SCN5A SCN10A TRPM8 KCNT1

4.01e-0534314411GO:0005261
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1D CACNA1F TRPC4AP ITPR1 ITPR2 ITPR3 TRPM8

4.21e-051291447GO:0005262
GeneOntologyMolecularFunctionmannosyltransferase activity

DPY19L3 DPY19L2 PIGV DPY19L4

4.64e-05281444GO:0000030
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

INPP4A INPP4B

5.16e-0521442GO:0016316
GeneOntologyMolecularFunctioninositol-3,4-bisphosphate 4-phosphatase activity

INPP4A INPP4B

5.16e-0521442GO:0052828
GeneOntologyMolecularFunctioninositol-1,3,4-trisphosphate 4-phosphatase activity

INPP4A INPP4B

5.16e-0521442GO:0017161
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR1 ITPR2 ITPR3 TRPM8

7.01e-05311444GO:0099604
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

SLC43A2 ABCC5 SLC35B2 ABCC6 GJA1

7.82e-05611445GO:1901682
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

CHRNG ITPR1 ITPR2 ITPR3 TRPM8 ANO3 KCNT1 GABRR3

8.08e-051931448GO:0015276
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R16 TAS2R8 TAS1R1 TAS2R41

9.02e-05331444GO:0008527
GeneOntologyMolecularFunctionligand-gated channel activity

CHRNG ITPR1 ITPR2 ITPR3 TRPM8 ANO3 KCNT1 GABRR3

9.33e-051971448GO:0022834
GeneOntologyMolecularFunctionmonoatomic cation:bicarbonate symporter activity

SLC4A7 SLC4A8 SLC4A10

9.96e-05131443GO:0140410
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1D CACNA1F TRPC4AP ITPR1 ITPR2 ITPR3 TRPM8

1.14e-041511447GO:0015085
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR1 ITPR2 ITPR3

1.26e-04141443GO:0070679
GeneOntologyMolecularFunctionsodium,bicarbonate:chloride antiporter activity

SLC4A8 SLC4A10

1.54e-0431442GO:0140892
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC9A8 SLC29A3 SLC22A25 SLC4A7 SLC4A8 ABCC5 SLC35B2 ABCC6 SLC45A3 SLC17A1 SLC4A10 ABCC12

1.81e-0447714412GO:0022804
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9A8 SLC4A7 SLC4A8 SLC17A1 SCN5A SCN10A SLC4A10

2.45e-041711447GO:0015081
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR1 ITPR2 ITPR3

2.77e-04181443GO:0015278
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate phosphatase activity

INPP4A INPP4B

3.07e-0441442GO:0106017
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

CHRNG ITPR1 ITPR2 ITPR3 TRPM8 KCNT1

5.38e-041401446GO:0099094
GeneOntologyMolecularFunctionankyrin binding

CACNA1D NRCAM SCN5A

5.85e-04231443GO:0030506
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential

SCN5A SCN10A

7.60e-0461442GO:0086006
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R16 TAS2R8 TAS2R41

9.46e-04271443GO:0033038
GeneOntologyMolecularFunctionglutathione transmembrane transporter activity

ABCC5 GJA1

1.06e-0371442GO:0034634
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC43A2 SLC22A25 SLC4A7 SLC4A8 ABCC5 SLC35B2 GJA1 SLC4A10

1.31e-032931448GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9A8 SLC22A25 SLC4A7 SLC4A8 SLC35B2 SLC45A3 SLC17A1 SLC4A10

1.40e-032961448GO:0015291
GeneOntologyMolecularFunctioninositol bisphosphate phosphatase activity

INPP4A INPP4B

1.41e-0381442GO:0016312
GeneOntologyMolecularFunctionbicarbonate transmembrane transporter activity

SLC4A7 SLC4A8 SLC4A10

1.56e-03321443GO:0015106
GeneOntologyMolecularFunctionsolute:inorganic anion antiporter activity

SLC4A7 SLC4A8 SLC4A10

1.56e-03321443GO:0005452
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR1 ITPR2 ITPR3

1.71e-03331443GO:0005217
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC4A7 SLC4A8 SLC45A3 SLC17A1 SLC4A10

1.72e-031191445GO:0015294
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

ABCC5 GJA1

1.80e-0391442GO:0042937
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC5 ABCC6

2.24e-03101442GO:0043225
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 4-phosphatase activity

INPP4A INPP4B

2.24e-03101442GO:0034596
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC4A7 SLC4A8 SLC17A1 SLC4A10

2.81e-03811444GO:0015370
GeneOntologyMolecularFunctionantiporter activity

SLC9A8 SLC4A7 SLC4A8 SLC35B2 SLC4A10

3.27e-031381445GO:0015297
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC9A8 SLC4A8 SLC4A10

3.67e-03431443GO:0140828
GeneOntologyMolecularFunctionchloride:bicarbonate antiporter activity

SLC4A8 SLC4A10

3.82e-03131442GO:0140900
GeneOntologyMolecularFunctionbicarbonate:monoatomic anion antiporter activity

SLC4A8 SLC4A10

3.82e-03131442GO:0140829
GeneOntologyMolecularFunctioninositol trisphosphate phosphatase activity

INPP4A INPP4B

4.44e-03141442GO:0046030
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1D CACNA1F

4.44e-03141442GO:0008331
GeneOntologyMolecularFunctionsymporter activity

SLC4A7 SLC4A8 SLC45A3 SLC17A1 SLC4A10

4.67e-031501445GO:0015293
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC4A7 SLC4A8 SLC4A10 ANO3 GABRR3

4.80e-031511445GO:0008509
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC5 ABCC6

5.10e-03151442GO:0008559
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC5 ABCC6 ABCC12

5.31e-03491443GO:0140359
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC5 GJA1

5.80e-03161442GO:0015562
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

ABCC5 GJA1

5.80e-03161442GO:0035673
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

MED24 MED12

7.33e-03181442GO:0042809
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

CACNA1F OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 PCARE OR2T10 OR6M1 OR6N1 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 SCN10A TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5

1.68e-1258214224GO:0050906
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

CACNA1D GPR22 OR7C2 OR7A5 OR2AP1 CXCL10 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 PREX2 ADCY8 OR6N1 ITPR1 ITPR3 ADGRG7 OR51F2 TAS2R16 TAS2R8 ADRA1A OR4A8 ADGRG2 OR4A5 GPR158 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 CCL1 TAS2R41 ADGRD2 OR4D5 GNRHR

2.81e-12139514236GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

CACNA1F OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 PCARE OR2T10 TLR6 OR6M1 OR6N1 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 SCN10A TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5 ANO3

3.84e-1272214226GO:0051606
GeneOntologyBiologicalProcesssensory perception

OTOA CACNA1D CACNA1F SLC4A7 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 PCARE OR2T10 ABCC6 OR6M1 OR6N1 ITPR3 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 SCN10A TAS1R1 SLC4A10 OR1L6 OR1E3 TRPM8 TAS2R41 OR4D5

7.23e-12107214231GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 TLR6 OR6M1 OR6N1 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5

1.11e-1152414222GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5

1.92e-1148514221GO:0050907
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 ITPR3 OR51F2 TAS2R16 TAS2R8 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5

2.55e-1154714222GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

7.69e-0943214217GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

2.27e-0846514217GO:0007608
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 ABCC6 CHRNG ITPR1 ITPR2 ITPR3 GJA1 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ANO3 KCNT1 GABRR3

6.14e-07111514224GO:0034220
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1D CACNA1F SLC9A8 SLC22A25 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 CLDN15 ABCC6 CHRNG ITPR1 ITPR2 ITPR3 GJA1 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ANO3 KCNT1 GABRR3

2.21e-06137414226GO:0006811
GeneOntologyBiologicalProcesspeptidyl-tryptophan modification

DPY19L3 DPY19L2 DPY19L4

6.29e-0661423GO:0018211
GeneOntologyBiologicalProcessprotein C-linked glycosylation via tryptophan

DPY19L3 DPY19L2 DPY19L4

6.29e-0661423GO:0018317
GeneOntologyBiologicalProcessprotein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

DPY19L3 DPY19L2 DPY19L4

6.29e-0661423GO:0018406
GeneOntologyBiologicalProcessprotein C-linked glycosylation

DPY19L3 DPY19L2 DPY19L4

6.29e-0661423GO:0018103
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 ITPR1 ITPR2 ITPR3 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 ANO3 KCNT1 GABRR3

6.43e-06101714221GO:0098660
GeneOntologyBiologicalProcessmetal ion transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 ITPR1 ITPR2 ITPR3 GJA1 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

1.73e-05100014220GO:0030001
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 ITPR1 ITPR2 ITPR3 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

1.91e-0592214219GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 ITPR1 ITPR2 ITPR3 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

2.56e-0594214219GO:0098655
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell membrane depolarization

GJA1 SCN5A SCN10A

3.70e-05101423GO:0060371
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC4A7 SLC4A8 ABCC5 ABCC6 SLC17A1 SLC4A10 ANO3 GABRR3

4.02e-051831428GO:0006820
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1D CACNA1F SLC9A8 TRPC4AP SLC4A7 SLC4A8 CXCL10 ABCC5 CHRNG ITPR1 ITPR2 ITPR3 GJA1 ADRA1A PIK3C2A SLC17A1 SCN5A SCN10A SLC4A10 TRPM8 KCNT1

4.39e-05115714221GO:0006812
GeneOntologyBiologicalProcesscell-cell signaling involved in cardiac conduction

CACNA1D GJA1 SCN5A SCN10A

8.50e-05341424GO:0086019
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC4A7 SLC4A8 ABCC5 ABCC6 SLC4A10 ANO3 GABRR3

9.28e-051531427GO:0098656
GeneOntologyBiologicalProcesssensory perception of taste

ITPR3 TAS2R16 TAS2R8 TAS1R1 TAS2R41

1.22e-04701425GO:0050909
GeneOntologyBiologicalProcesspurine ribonucleotide transport

ABCC5 SLC35B2 ABCC6 GJA1

1.62e-04401424GO:0015868
GeneOntologyBiologicalProcessadenine nucleotide transport

ABCC5 SLC35B2 ABCC6 GJA1

1.97e-04421424GO:0051503
GeneOntologyBiologicalProcesspurine nucleotide transport

ABCC5 SLC35B2 ABCC6 GJA1

2.36e-04441424GO:0015865
GeneOntologyBiologicalProcessinorganic anion transport

SLC4A7 SLC4A8 ABCC6 SLC17A1 SLC4A10 ANO3 GABRR3

2.53e-041801427GO:0015698
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

CACNA1F SLC9A8 SLC4A7 SLC4A8 CXCL10 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 SLC4A10 CCL1 TRPM8

3.15e-0461114213GO:0030003
GeneOntologyBiologicalProcesssensory perception of bitter taste

ITPR3 TAS2R16 TAS2R8 TAS2R41

3.31e-04481424GO:0050913
GeneOntologyBiologicalProcessnucleobase-containing compound transport

SLC29A3 AHCTF1 CKAP5 ABCC5 SLC35B2 ABCC6 GJA1 NUP188

3.37e-042491428GO:0015931
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

CXCL10 PTGER2 ADCY8 ADGRG7 ADRA1A ADGRG2 ADGRD2

3.63e-041911427GO:0007189
GeneOntologyBiologicalProcesscalcium ion homeostasis

CACNA1F CXCL10 ABCC6 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 CCL1 TRPM8

3.71e-0438914210GO:0055074
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CACNA1F SLC9A8 SLC4A7 SLC4A8 CXCL10 ABCC6 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 SLC4A10 CCL1 TRPM8

3.71e-0470514214GO:0055080
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

CACNA1F SLC9A8 SLC4A7 SLC4A8 CXCL10 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 SLC4A10 CCL1 TRPM8

3.74e-0462214213GO:0006873
GeneOntologyBiologicalProcessnucleotide transport

ABCC5 SLC35B2 ABCC6 GJA1

3.88e-04501424GO:0006862
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of taste

TAS2R16 TAS2R8 TAS1R1 TAS2R41

3.88e-04501424GO:0050912
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1F SLC9A8 SLC4A7 SLC4A8 CXCL10 ABCC6 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 SLC4A10 CCL1 TRPM8

4.39e-0471714214GO:0050801
GeneOntologyBiologicalProcessphosphatidylinositol-3-phosphate biosynthetic process

INPP4A INPP4B PIK3C2A

4.47e-04221423GO:0036092
GeneOntologyBiologicalProcessmembrane depolarization during SA node cell action potential

CACNA1D SCN5A

4.64e-0451422GO:0086046
GeneOntologyBiologicalProcessregulation of membrane potential

CACNA1D SLC4A8 NRCAM SYNE1 CKAP5 CHRNG GJA1 ADRA1A SCN5A SCN10A KCNT1 GABRR3

4.98e-0455914212GO:0042391
GeneOntologyBiologicalProcesscarbohydrate derivative transport

SLC29A3 ABCC5 SLC35B2 ABCC6 GJA1

5.33e-04961425GO:1901264
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC9A8 SLC4A7 SLC4A8 SLC17A1 SCN5A SCN10A SLC4A10

6.04e-042081427GO:0035725
GeneOntologyBiologicalProcessprotein mannosylation

DPY19L3 DPY19L2 DPY19L4

6.58e-04251423GO:0035268
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

CACNA1D GJA1 SCN5A SCN10A

7.31e-04591424GO:0086065
GeneOntologyBiologicalProcessmannosylation

DPY19L3 DPY19L2 DPY19L4

7.40e-04261423GO:0097502
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1D CACNA1F CXCL10 ITPR1 ITPR2 ITPR3 ADRA1A

7.76e-042171427GO:0097553
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA1D CHRNG GJA1 LMOD3 ADRA1A SCN5A SCN10A

7.76e-042171427GO:0006941
GeneOntologyBiologicalProcessregulation of membrane depolarization

CACNA1D GJA1 SCN5A SCN10A

8.29e-04611424GO:0003254
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

CACNA1D CXCL10 PTGER2 ADCY8 ADGRG7 ADRA1A ADGRG2 ADGRD2

8.38e-042861428GO:0007188
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1F CXCL10 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 CCL1 TRPM8

8.71e-043591429GO:0006874
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA1D GJA1 SCN5A SCN10A

8.81e-04621424GO:0086002
GeneOntologyBiologicalProcessorganic anion transport

SLC43A2 SLC22A25 SLC4A7 SLC4A8 ABCC5 SLC35B2 ABCC6 GJA1 SLC17A1 PLA2G12A SLC4A10

8.91e-0451514211GO:0015711
GeneOntologyBiologicalProcesspositive regulation of cytosolic calcium ion concentration

PTGER2 ADCY8 ITPR1 ITPR3 GJA1 ADRA1A CCL1

9.34e-042241427GO:0007204
GeneOntologyBiologicalProcessintracellular chemical homeostasis

CACNA1D CACNA1F SLC9A8 SLC4A7 SLC4A8 CXCL10 ABCC6 ADCY8 INPP4B ITPR1 ITPR2 ITPR3 SLC4A10 CCL1 TRPM8

9.42e-0486614215GO:0055082
GeneOntologyBiologicalProcessbundle of His cell action potential

SCN5A SCN10A

9.66e-0471422GO:0086043
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte signaling

SCN5A SCN10A

9.66e-0471422GO:0086028
GeneOntologyBiologicalProcesssensory perception of umami taste

ITPR3 TAS1R1

9.66e-0471422GO:0050917
GeneOntologyBiologicalProcesssulfur compound transport

SLC43A2 ABCC5 SLC35B2 GJA1

1.05e-03651424GO:0072348
GeneOntologyBiologicalProcessregulation of cardiac muscle cell membrane repolarization

CACNA1D GJA1 SCN5A

1.13e-03301423GO:0099623
GeneOntologyBiologicalProcessglutathione transmembrane transport

ABCC5 GJA1

1.28e-0381422GO:0034775
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell membrane repolarization

CACNA1D SCN5A

1.28e-0381422GO:0060372
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell membrane depolarization

GJA1 SCN5A

1.28e-0381422GO:0060373
GeneOntologyCellularComponentapical plasma membrane

OTOA CACNA1D SLC9A8 SLC4A7 SLC4A8 ABCC5 ABCC6 ADCY8 ITPR3 GJA1 DUOX1 ADGRG2 SLC17A1 SLC4A10

6.60e-0648714314GO:0016324
GeneOntologyCellularComponentapical part of cell

OTOA CACNA1D SLC9A8 SLC4A7 SLC4A8 ABCC5 ABCC6 ADCY8 ITPR3 GJA1 DUOX1 ADGRG2 SLC17A1 INSC SLC4A10

1.37e-0559214315GO:0045177
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR1 ITPR2 ITPR3

2.55e-0591433GO:0031095
GeneOntologyCellularComponentsynaptic membrane

CACNA1D SLC4A8 NRCAM SYNE1 ADCY8 CHRNG ITPR1 ADRA1A GPR158 SCN10A DNM3 PCDH10 KCNT1 GABRR3

4.83e-0558314314GO:0097060
GeneOntologyCellularComponentplatelet dense tubular network

ITPR1 ITPR2 ITPR3

4.97e-05111433GO:0031094
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

DPY19L3 OR7C2 OR7A5 SYNE1 MPDU1 SREBF2 TMEM119 HACD4 SLC35B2 PIGV MBOAT4 ABCC6 TMCC3 GGCX ITPR1 ITPR2 ITPR3 GJA1 SEC22C TRPM8 ABCC12

2.74e-04132714321GO:0042175
GeneOntologyCellularComponentendoplasmic reticulum membrane

DPY19L3 OR7C2 OR7A5 MPDU1 SREBF2 TMEM119 HACD4 SLC35B2 PIGV MBOAT4 ABCC6 TMCC3 GGCX ITPR1 ITPR2 ITPR3 GJA1 SEC22C TRPM8 ABCC12

5.18e-04129314320GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

DPY19L3 OR7C2 OR7A5 MPDU1 SREBF2 TMEM119 HACD4 SLC35B2 PIGV MBOAT4 ABCC6 TMCC3 GGCX ITPR1 ITPR2 ITPR3 GJA1 SEC22C TRPM8 ABCC12

5.49e-04129914320GO:0098827
GeneOntologyCellularComponentnuclear membrane

DPY19L3 DPY19L2 INPP4A SYNE1 AHCTF1 ITPR1 ITPR3 ADRA1A DPY19L4

6.83e-043491439GO:0031965
GeneOntologyCellularComponentnuclear inner membrane

DPY19L3 DPY19L2 ITPR1 DPY19L4

7.14e-04591434GO:0005637
DomainGPCR_Rhodpsn_7TM

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 OR51F2 TAS2R8 ADRA1A OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5 GNRHR

1.22e-0767013920IPR017452
DomainG_PROTEIN_RECEP_F1_2

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 OR51F2 TAS2R8 ADRA1A OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5 GNRHR

2.00e-0769113920PS50262
DomainGPCR_Rhodpsn

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 OR51F2 TAS2R8 ADRA1A OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5 GNRHR

2.05e-0769213920IPR000276
DomainARM-type_fold

ARMC7 TRPC4AP CKAP5 PSMD5 BTAF1 LYST ITPR1 ITPR2 DNAAF5 PIK3C2A INF2 INSC MMS19 NUP188

2.45e-0733913914IPR016024
DomainOlfact_rcpt

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5

2.45e-0739313915IPR000725
DomainInsP3_rcpt-bd

ITPR1 ITPR2 ITPR3

4.03e-0731393IPR000493
Domain7tm_1

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 OR51F2 ADRA1A OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5 GNRHR

6.63e-0767713919PF00001
DomainG_PROTEIN_RECEP_F1_1

GPR22 OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 PTGER2 OR6M1 OR6N1 OR51F2 ADRA1A OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5 GNRHR

7.90e-0768513919PS00237
DomainDpy19

DPY19L3 DPY19L2 DPY19L4

1.60e-0641393PF10034
DomainDpy-19/Dpy-19-like

DPY19L3 DPY19L2 DPY19L4

1.60e-0641393IPR018732
DomainIon_trans_dom

CACNA1D CACNA1F ITPR1 ITPR2 ITPR3 SCN5A SCN10A TRPM8

2.18e-061141398IPR005821
DomainIon_trans

CACNA1D CACNA1F ITPR1 ITPR2 ITPR3 SCN5A SCN10A TRPM8

2.18e-061141398PF00520
DomainRIH_assoc

ITPR1 ITPR2 ITPR3

7.94e-0661393PF08454
DomainRIH_assoc-dom

ITPR1 ITPR2 ITPR3

7.94e-0661393IPR013662
DomainRIH_dom

ITPR1 ITPR2 ITPR3

7.94e-0661393IPR000699
DomainIns145_P3_rcpt

ITPR1 ITPR2 ITPR3

7.94e-0661393IPR014821
DomainRyanodine_recept-rel

ITPR1 ITPR2 ITPR3

7.94e-0661393IPR015925
Domain-

ITPR1 ITPR2 ITPR3

7.94e-06613931.25.10.30
DomainRYDR_ITPR

ITPR1 ITPR2 ITPR3

7.94e-0661393PF01365
DomainIns145_P3_rec

ITPR1 ITPR2 ITPR3

7.94e-0661393PF08709
DomainANION_EXCHANGER_2

SLC4A7 SLC4A8 SLC4A10

1.38e-0571393PS00220
DomainANION_EXCHANGER_1

SLC4A7 SLC4A8 SLC4A10

1.38e-0571393PS00219
DomainBand3_cytoplasmic_dom

SLC4A7 SLC4A8 SLC4A10

3.28e-0591393IPR013769
DomainBand_3_cyto

SLC4A7 SLC4A8 SLC4A10

3.28e-0591393PF07565
Domain-

SLC4A7 SLC4A8 SLC4A10

3.28e-05913933.40.1100.10
DomainMIR

ITPR1 ITPR2 ITPR3

4.66e-05101393PS50919
DomainMIR

ITPR1 ITPR2 ITPR3

4.66e-05101393PF02815
DomainMIR

ITPR1 ITPR2 ITPR3

4.66e-05101393SM00472
DomainHCO3_cotransp

SLC4A7 SLC4A8 SLC4A10

4.66e-05101393PF00955
DomainHCO3_transpt_C

SLC4A7 SLC4A8 SLC4A10

4.66e-05101393IPR011531
DomainMIR_motif

ITPR1 ITPR2 ITPR3

4.66e-05101393IPR016093
DomainPTrfase/Anion_transptr

SLC4A7 SLC4A8 SLC4A10

4.66e-05101393IPR016152
DomainHCO3_transpt_euk

SLC4A7 SLC4A8 SLC4A10

4.66e-05101393IPR003020
DomainCAC1F_C

CACNA1D CACNA1F

1.64e-0431392IPR031688
DomainCAC1F_C

CACNA1D CACNA1F

1.64e-0431392PF16885
Domain-

ARMC7 CKAP5 PSMD5 BTAF1 DNAAF5 INSC MMS19 MED12

2.61e-0422213981.25.10.10
DomainVDCC_L_a1su

CACNA1D CACNA1F

3.27e-0441392IPR005446
DomainHEAT

CKAP5 BTAF1 DNAAF5 MMS19

4.43e-04481394PF02985
DomainAnion_exchange

SLC4A7 SLC4A10

5.42e-0451392IPR001717
DomainNa/HCO3_transpt

SLC4A8 SLC4A10

5.42e-0451392IPR003024
DomainABC_membrane

ABCC5 ABCC6 ABCC12

7.28e-04241393PF00664
DomainChannel_four-helix_dom

CACNA1D CACNA1F SCN5A SCN10A

8.55e-04571394IPR027359
Domain-

CACNA1D CACNA1F SCN5A SCN10A

8.55e-045713941.20.120.350
DomainHEAT

CKAP5 BTAF1 DNAAF5 MMS19

9.13e-04581394IPR000357
DomainTAS2R

TAS2R16 TAS2R8 TAS2R41

9.25e-04261393PF05296
DomainT2R

TAS2R16 TAS2R8 TAS2R41

9.25e-04261393IPR007960
DomainARM-like

ARMC7 CKAP5 PSMD5 BTAF1 DNAAF5 INSC MMS19 MED12

9.48e-042701398IPR011989
DomainVDCC_a1su_IQ

CACNA1D CACNA1F

1.13e-0371392IPR014873
DomainGPHH

CACNA1D CACNA1F

1.13e-0371392PF16905
DomainGPHH_dom

CACNA1D CACNA1F

1.13e-0371392IPR031649
DomainCa_chan_IQ

CACNA1D CACNA1F

1.13e-0371392SM01062
DomainCa_chan_IQ

CACNA1D CACNA1F

1.13e-0371392PF08763
DomainABC_TM1F

ABCC5 ABCC6 ABCC12

1.15e-03281393PS50929
DomainABC1_TM_dom

ABCC5 ABCC6 ABCC12

1.15e-03281393IPR011527
DomainLRRCT

LRRN1 TLR6 CD180

1.71e-03321393PF01463
DomainHEAT_REPEAT

CKAP5 BTAF1 DNAAF5 MMS19

1.84e-03701394PS50077
DomainGPS

ADGRG7 ADGRG2 ADGRD2

2.04e-03341393SM00303
DomainGPS

ADGRG7 ADGRG2 ADGRD2

2.22e-03351393PF01825
DomainNa_channel_asu

SCN5A SCN10A

2.38e-03101392IPR001696
DomainNa_trans_assoc

SCN5A SCN10A

2.38e-03101392IPR010526
DomainVDCCAlpha1

CACNA1D CACNA1F

2.38e-03101392IPR002077
DomainNa_trans_assoc

SCN5A SCN10A

2.38e-03101392PF06512
DomainGPS

ADGRG7 ADGRG2 ADGRD2

2.41e-03361393PS50221
DomainGPS

ADGRG7 ADGRG2 ADGRD2

2.60e-03371393IPR000203
DomainMFS_1

SLC43A2 SLC22A25 SLC45A3 SLC17A1

2.61e-03771394PF07690
DomainMFS

SLC43A2 SLC22A25 SLC45A3 SLC17A1

2.61e-03771394IPR011701
DomainABC_transporter_CS

ABCC5 ABCC6 ABCC12

3.75e-03421393IPR017871
DomainABC_tran

ABCC5 ABCC6 ABCC12

5.46e-03481393PF00005
DomainABC_TRANSPORTER_2

ABCC5 ABCC6 ABCC12

5.46e-03481393PS50893
DomainABC_TRANSPORTER_1

ABCC5 ABCC6 ABCC12

5.79e-03491393PS00211
DomainG_PROTEIN_RECEP_F2_2

ADGRG7 ADGRG2 ADGRD2

6.12e-03501393PS00650
Domain7tm_2

ADGRG7 ADGRG2 ADGRD2

6.12e-03501393PF00002
DomainABC_transporter-like

ABCC5 ABCC6 ABCC12

6.12e-03501393IPR003439
DomainWH2

LMOD3 INF2

6.16e-03161392PF02205
DomainRmlC_Cupin

GGCX ADO

6.16e-03161392IPR011051
DomainHEAT_type_2

CKAP5 DNAAF5

6.95e-03171392IPR021133
PathwayREACTOME_SENSORY_PERCEPTION

CACNA1D OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 ITPR3 OR51F2 TAS2R16 TAS2R8 GPC3 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 TAS1R1 OR1L6 OR1E3 TAS2R41 OR4D5

1.98e-1063611424M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

3.93e-0841711417M4072
PathwayKEGG_GNRH_SIGNALING_PATHWAY

CACNA1D CACNA1F HBEGF ADCY8 ITPR1 ITPR2 ITPR3 PLA2G12A GNRHR

1.21e-071011149M1979
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR7C2 OR7A5 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A5 OR6C4 OR6C1 OR5H6 OR1L6 OR4D5

3.00e-0638911414M14091
PathwayKEGG_TASTE_TRANSDUCTION

ADCY8 ITPR3 TAS2R16 TAS2R8 TAS1R1 TAS2R41

3.68e-06521146M5785
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

CACNA1D CACNA1F ADCY8 ITPR1 ITPR2 ITPR3 ADRA1A PLA2G12A

4.12e-061151148M9387
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

5.09e-0651143M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.01e-0561143M47960
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

INPP4A INPP4B ITPR1 ITPR2 ITPR3 PIK3C2A

3.38e-05761146M9052
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

ITPR3 TAS2R16 TAS2R8 TAS1R1 TAS2R41

3.70e-05471145M42524
PathwayWP_GPCRS_ODORANT

GPR22 OR7A5 ADGRG7 GPR137C GPR158 OR5H6 TAS1R1 OR1E3

4.01e-051571148MM15872
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

4.18e-0591143M47852
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A7 SLC4A8 SLC4A10

5.93e-05101143M27335
PathwayREACTOME_BICARBONATE_TRANSPORTERS

SLC4A7 SLC4A8 SLC4A10

5.93e-05101143MM15073
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

5.93e-05101143M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

8.11e-05111143M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR1 ITPR2 ITPR3

8.11e-05111143M27466
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC43A2 SLC9A8 SLC29A3 TRPC4AP SLC4A7 SLC4A8 PEX3 ABCC5 PSMD5 SLC35B2 ABCC6 ADCY8 SLC45A3 SLC17A1 SLC4A10 TRPM8 ANO3

8.44e-0573611417M27287
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

ITPR3 TAS2R16 TAS1R1 TAS2R41

1.08e-04311144MM15691
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC43A2 SLC9A8 SLC29A3 TRPC4AP SLC4A7 SLC4A8 PEX3 ABCC5 PSMD5 SLC35B2 ABCC6 SLC45A3 SLC17A1 SLC4A10 TRPM8 ANO3

1.14e-0468111416MM14985
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC43A2 SLC9A8 SLC29A3 SLC4A7 SLC4A8 SLC35B2 SLC45A3 SLC17A1 SLC4A10

1.33e-042381149MM15076
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

1.39e-04131143M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.39e-04131143M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

1.39e-04131143M47751
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

1.39e-04131143MM14553
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC43A2 SLC9A8 SLC29A3 SLC4A7 SLC4A8 SLC35B2 SLC45A3 SLC17A1 SLC4A10

1.87e-042491149M5988
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1D ADCY8 ITPR1 ITPR2 ITPR3 GJA1 ADRA1A

1.89e-041471147MM15854
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

INPP4A INPP4B PIK3C2A

2.18e-04151143MM14643
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1D ADCY8 ITPR1 ITPR2 ITPR3 GJA1 ADRA1A

2.22e-041511147M39329
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

CXCL10 ADCY8 ITPR1 ITPR2 ITPR3 TAS2R16 TAS2R8 TAS1R1 CCL1 TAS2R41

2.29e-0431411410M600
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC43A2 SLC9A8 SLC4A7 SLC4A8 SLC17A1 SLC4A10

2.40e-041081146M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC43A2 SLC9A8 SLC4A7 SLC4A8 SLC17A1 SLC4A10

2.52e-041091146MM15074
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR1 ITPR2 ITPR3

2.67e-04161143M26945
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE

INPP4A INPP4B PIK3C2A

2.67e-04161143M639
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R16 TAS2R8 TAS1R1 TAS2R41

2.68e-04391144M793
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ADCY8 ITPR1 ITPR2 ITPR3

3.26e-04411144M512
PathwayWP_ALZHEIMERS_DISEASE

CACNA1D CACNA1F ITPR1 ITPR2 ITPR3

3.27e-04741145MM15962
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ADCY8 ITPR1 ITPR2 ITPR3

3.58e-04421144M791
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1D ADCY8 ITPR1 ITPR2 ITPR3

4.18e-04781145M1921
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR1 ITPR2 ITPR3

4.54e-04191143M27423
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

4.54e-04191143M47760
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3

4.54e-04191143M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

5.31e-04201143M47688
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1D CACNA1F ADCY8 ITPR1 ITPR2 ITPR3 ADRA1A

6.02e-041781147M2890
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

6.16e-04211143M47689
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

INPP4A INPP4B PIK3C2A RAB4A

7.01e-04501144MM14641
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR1 ITPR2 ITPR3 ADRA1A

7.01e-04501144M47951
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

7.09e-04221143M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

7.09e-04221143M47675
PathwayKEGG_GAP_JUNCTION

ADCY8 ITPR1 ITPR2 ITPR3 GJA1

8.06e-04901145M4013
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR1 ITPR2 ITPR3

8.11e-04231143M47676
PathwayREACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE

INPP4A INPP4B PIK3C2A RAB4A

8.75e-04531144M662
PathwayREACTOME_SENSORY_PERCEPTION

OR2W1 ITPR3 TAS2R16 GPC3 TAS1R1 OR1E3 TAS2R41

8.84e-041901147MM15687
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ADCY8 ITPR1 ITPR2 ITPR3

9.40e-04541144M26911
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1D CACNA1F

9.52e-0461142M47762
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

1.04e-03251143MM14511
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

1.31e-03271143MM15053
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR1 ITPR2 ITPR3

1.31e-03271143M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR1 ITPR2 ITPR3

1.46e-03281143M924
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1D ITPR1 ITPR2 ITPR3

1.48e-03611144MM15071
PathwayREACTOME_SIGNALING_BY_GPCR

CXCL10 HBEGF PTGER2 ADCY8 ITPR1 ITPR2 ITPR3 TAS2R16 TAS2R8 ADRA1A TAS1R1 CCL1 TAS2R41 GNRHR

1.57e-0370211414M746
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1D ADCY8 ITPR1 ITPR2 ITPR3

1.82e-031081145M17034
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

NRCAM SCN5A SCN10A

1.96e-03311143M877
PathwayREACTOME_SIGNALING_BY_GPCR

CXCL10 HBEGF PTGER2 ADCY8 ITPR1 ITPR2 ITPR3 TAS2R16 ADRA1A TAS1R1 CCL1 TAS2R41 GNRHR

2.14e-0364611413MM14962
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR1 ITPR2 ITPR3

2.15e-03321143MM14983
PathwayREACTOME_DEFECTIVE_FACTOR_IX_CAUSES_HEMOPHILIA_B

F8 GGCX

2.25e-0391142M39001
PathwayKEGG_LONG_TERM_DEPRESSION

ITPR1 ITPR2 ITPR3 PLA2G12A

2.47e-03701144M8232
PathwayKEGG_LONG_TERM_POTENTIATION

ADCY8 ITPR1 ITPR2 ITPR3

2.47e-03701144M3115
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1D ITPR1 ITPR2 ITPR3

2.73e-03721144MM14631
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

CACNA1F ITPR1 ITPR2 ITPR3

3.02e-03741144M48080
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR1 ITPR2 ITPR3

3.03e-03361143M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR1 ITPR2 ITPR3

3.03e-03361143M39831
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R16 TAS1R1 TAS2R41

3.28e-03371143MM15067
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

1.75e-103401441411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

1.75e-103401441411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

1.96e-103431441432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C1 OR5H6 OR1L6 OR1E3 OR4D5

2.20e-103461441414611657
Pubmed

The human olfactory receptor gene family.

OR7C2 OR7A5 OR2AP1 OR4D1 OR2W1 OR2T10 OR6M1 OR6N1 OR51F2 OR4A8 OR4A5 OR6C4 OR5H6 OR1L6 OR1E3 OR4D5

1.04e-095411441614983052
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR1 ITPR2 ITPR3

6.95e-083144310874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR1 ITPR2 ITPR3

6.95e-083144320395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR1 ITPR2 ITPR3

6.95e-083144317437169
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR1 ITPR2 ITPR3

6.95e-083144318547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR1 ITPR2 ITPR3

6.95e-083144336350267
Pubmed

The versatility and universality of calcium signalling.

ITPR1 ITPR2 ITPR3

6.95e-083144311413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

6.95e-083144326009177
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR1 ITPR2 ITPR3

6.95e-08314431693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR1 ITPR2 ITPR3

6.95e-083144323955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR1 ITPR2 ITPR3

6.95e-083144331979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR1 ITPR2 ITPR3

6.95e-083144324904548
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR1 ITPR2 ITPR3

6.95e-08314439858485
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR1 ITPR2 ITPR3

6.95e-08314439808793
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR1 ITPR2 ITPR3

6.95e-083144318194433
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR1 ITPR2 ITPR3

6.95e-083144327777977
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR1 ITPR2 ITPR3

6.95e-083144317581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR1 ITPR2 ITPR3

6.95e-083144318241669
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR1 ITPR2 ITPR3

6.95e-083144319068129
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

6.95e-083144317327232
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR1 ITPR2 ITPR3

6.95e-083144316014380
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR1 ITPR2 ITPR3

6.95e-083144317890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR1 ITPR2 ITPR3

6.95e-083144323983250
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

6.95e-083144320427533
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR1 ITPR2 ITPR3

2.77e-074144325215520
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR1 ITPR2 ITPR3

2.77e-074144311163362
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR1 ITPR2 ITPR3

2.77e-074144321424589
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR1 ITPR2 ITPR3

2.77e-074144328615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR1 ITPR2 ITPR3

2.77e-074144310828023
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR1 ITPR2 ITPR3

2.77e-074144328419336
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR1 ITPR2 ITPR3

2.77e-074144335494252
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1D CACNA1F ITPR1 ITPR2 ITPR3

5.10e-0738144530786075
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR7C2 OR2W1 OR51F2 OR4A8 OR4A5 OR1E3

6.67e-0774144615081110
Pubmed

Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.

SLC4A7 SLC4A8 SLC4A10

6.91e-075144323500099
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR1 ITPR2 ITPR3

6.91e-075144321568942
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR1 ITPR2 ITPR3

1.38e-066144323463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR1 ITPR2 ITPR3

1.38e-066144325966694
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR1 ITPR2 ITPR3

1.38e-066144321762810
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR1 ITPR2 ITPR3

1.38e-066144320519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR1 ITPR2 ITPR3

1.38e-066144316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR1 ITPR2 ITPR3

2.40e-067144311860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR1 ITPR2 ITPR3

2.40e-067144322495310
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC5 ABCC6 ABCC12

3.83e-068144315802388
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR7C2 OR7A5 OR4D1 OR2W1 OR6M1 OR6N1 OR6C1 OR1L6

3.93e-06219144812213199
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR1 ITPR2 ITPR3

5.73e-069144325737585
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR1 ITPR2 ITPR3

1.12e-0511144327514653
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

CACNA1D NRCAM CKAP5 ITPR1 SLC4A10 DNM3

1.63e-05128144630995482
Pubmed

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

SCN5A SCN10A

1.70e-052144224642470
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

1.70e-05214429065779
Pubmed

A 50% reduction of excitability but not of intercellular coupling affects conduction velocity restitution and activation delay in the mouse heart.

GJA1 SCN5A

1.70e-052144221673812
Pubmed

Association of the CAG repeat polymorphism in mitochondrial polymerase gamma (POLG1) with male infertility: a case-control study in an Algerian population.

POLG MED12

1.70e-052144234077112
Pubmed

The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.

ITPR1 ITPR3

1.70e-052144215890645
Pubmed

K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.

SLC4A8 SLC4A10

1.70e-052144238674160
Pubmed

Cx37 and Cx43 localize to zona pellucida in mouse ovarian follicles.

GJD4 GJA1

1.70e-052144216613781
Pubmed

Spatiotemporal expression of connexin 39 and -43 during myoblast differentiation in cultured cells and in the mouse embryo.

GJD4 GJA1

1.70e-052144216613780
Pubmed

MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.

ABCC5 ABCC12

1.70e-052144235121660
Pubmed

Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.

ABCC6 GGCX

1.70e-052144218800149
Pubmed

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

SCN5A SCN10A

1.70e-052144215047701
Pubmed

Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.

ITPR1 ITPR2

1.70e-052144215201137
Pubmed

Gap junctions - guards of excitability.

GJA1 SCN5A

1.70e-052144226009199
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

1.70e-052144225966695
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.70e-05214428081734
Pubmed

The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.

INPP4A INPP4B

1.70e-05214427608176
Pubmed

Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.

ITPR1 ITPR2

1.70e-052144223582047
Pubmed

The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.

INPP4A INPP4B

1.70e-05214429295334
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

1.70e-052144215632133
Pubmed

Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.

ITPR1 ITPR3

1.70e-05214427559486
Pubmed

Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model.

ITPR2 GJA1

1.70e-052144227991861
Pubmed

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.

ITPR1 ITPR3

1.70e-052144220843799
Pubmed

Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.

ITPR1 ITPR2

1.70e-052144219120126
Pubmed

C-terminal modulator controls Ca2+-dependent gating of Ca(v)1.4 L-type Ca2+ channels.

CACNA1D CACNA1F

1.70e-052144216921373
Pubmed

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.

SCN5A SCN10A

1.70e-052144224998131
Pubmed

Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis.

GJA1 SCN5A

1.70e-052144234561429
Pubmed

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

SCN5A SCN10A

1.70e-052144224360055
Pubmed

Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.

SCN5A SCN10A

1.70e-052144232330377
Pubmed

Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation.

HBEGF PTGER2

1.70e-052144235102343
Pubmed

Dose-related ethanol intake, Cx43 and Nav1.5 remodeling: Exploring insights of altered ventricular conduction and QRS fragmentation in excessive alcohol users.

GJA1 SCN5A

1.70e-052144229097069
Pubmed

Isolation and sequence determination of cDNA encoding mouse rab 4 and candidate approach for the beige mutation in mice.

LYST RAB4A

1.70e-05214428950022
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

1.70e-052144217496801
Pubmed

Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.

ITPR1 ITPR3

1.70e-05214428663526
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

1.70e-052144224901844
Pubmed

Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a.

CACNA1D SCN5A

1.70e-052144215932895
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

1.70e-052144233854148
Pubmed

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

GJA1 SCN5A

1.70e-052144225139742
Pubmed

An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.

ITPR1 ITPR2

1.70e-052144218708078
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

1.70e-052144219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

1.70e-05214428063813
Pubmed

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.

SCN5A SCN10A

1.70e-052144231292628
Pubmed

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

ITPR1 ITPR3

1.70e-05214421374893
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

1.70e-052144216195467
Pubmed

Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.

SLC4A7 SLC4A10

1.70e-052144217928512
Pubmed

Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.

HBEGF ITPR3

1.70e-052144233400994
Pubmed

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.

ITPR1 ITPR3

1.70e-052144220813840
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

1.70e-052144215713744
Pubmed

CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype.

CACNA1D CLDN14

1.70e-052144219664321
Pubmed

Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling.

ITPR1 GJA1

1.70e-052144225262337
InteractionGPR182 interactions

POLG AHCTF1 PEX3 FASTKD1 SREBF2 SLC35B2 BTAF1 GGCX DNAAF5 GJA1 PIK3C2A SIMC1 DNM3 MMS19

1.94e-0645513314int:GPR182
InteractionTRPC4 interactions

TRPC4AP ITPR1 ITPR2 ITPR3

1.46e-05231334int:TRPC4
InteractionDNAJC1 interactions

SLC4A7 SYNE1 AHCTF1 TMCC3 ITPR1 ITPR2 ITPR3 GPC3 INF2 INSC CMTM7

2.81e-0536113311int:DNAJC1
InteractionTRPC1 interactions

TRPC4AP ITPR1 ITPR2 ITPR3

3.79e-05291334int:TRPC1
InteractionSCN10A interactions

CACNA1D SCN5A SCN10A

4.46e-05111333int:SCN10A
InteractionCMKLR1 interactions

PEX3 FASTKD1 SLC35B2 BTAF1 DNAAF5 DNM3

5.60e-051011336int:CMKLR1
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR1 ITPR2 ITPR3

2.38e-0731133297
GeneFamilySolute carriers

SLC43A2 SLC9A8 SLC29A3 SLC22A25 SLC4A7 SLC4A8 SLC35B2 SLC7A4 SLC45A3 SLC17A1 SLC4A10

3.73e-0539511311752
GeneFamilyATP binding cassette subfamily C

ABCC5 ABCC6 ABCC12

6.50e-05131133807
GeneFamilyOlfactory receptors, family 6

OR6M1 OR6N1 OR6C4 OR6C1

2.88e-04511134153
GeneFamilyAdhesion G protein-coupled receptors, subfamily G

ADGRG7 ADGRG2

7.97e-0471132917
GeneFamilySodium voltage-gated channel alpha subunits

SCN5A SCN10A

1.35e-03911321203
GeneFamilyTaste 2 receptors

TAS2R16 TAS2R8 TAS2R41

1.84e-033911331162
GeneFamilyNon-clustered protocadherins

PCDH10 PCDH18

2.45e-0312113221
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BNC2 LRRN1 NRCAM NDST3 SEMA6D GPR137C COL21A1 INSC ANO3 PCDH18

6.91e-101921431072881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC43A2 CACNA1D CLDN14 SLC4A7 SLC4A8 NRCAM ITPR1 ITPR2 SEMA6D

8.35e-09183143931ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC43A2 CACNA1D CLDN14 SLC4A7 SLC4A8 NRCAM ITPR1 ITPR2 SEMA6D

9.17e-091851439898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLDN14 NRCAM PREX2 INPP4B SEMA6D GPR158 INSC PCDH18

1.21e-071791438dc6cd46fa652b296ddbc41855f6377946d0a4cdc
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OTOA CACNA1D BNC2 ADRA1A GPC3 COL21A1 ABCC12

1.65e-071251437b162a5bfbb8ac5e65e13578fef9de442a9e4fd8b
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 INPP4B SEMA6D GPR158 INSC DOCK6 PCDH18

1.98e-0719114381626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 INPP4B SEMA6D GPR158 INSC DOCK6 PCDH18

1.98e-071911438716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNC2 SLC4A8 DYRK4 ITPR2 ADGRG2 PCDH10 ANO3

1.32e-06170143717bd7fd25a2657cb536ad47e294332920f759e95
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRCAM PREX2 INPP4B SEMA6D GPR158 INSC DOCK6

1.79e-061781437185b44700f06ec58b3c09c80520502166c965fd6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

INPP4B ADRA1A SEMA6D COL21A1 SCN5A PCDH10 PCDH18

1.86e-061791437c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC43A2 CACNA1D CLDN14 SLC4A7 NRCAM ITPR2 SEMA6D

2.08e-061821437041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D CLDN14 SLC4A7 SLC4A8 ITPR1 ITPR2 SEMA6D

2.49e-061871437b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRN1 NRCAM TMEM119 NDST3 PCDH18 GNRHR MEGF10

2.67e-061891437a5306561026e4dfcc39beeb785e5108ac595d136
ToppCellfacs-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRN1 NRCAM TMEM119 NDST3 PCDH18 GNRHR MEGF10

2.67e-061891437381058f55908f84375b54601d617389ef43ab855
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRN1 NRCAM TMEM119 NDST3 PCDH18 GNRHR MEGF10

2.67e-061891437302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1D BNC2 INPP4B ADRA1A GPC3 COL21A1 ANO3

2.96e-06192143799ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM SYNE1 ADRA1A GPC3 COL21A1

3.17e-06194143760622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

CACNA1D BNC2 NRCAM INPP4B ADRA1A GPC3 COL21A1

3.28e-061951437603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CACNA1D NRCAM SYNE1 PREX2 GPC3 COL21A1 PCDH18

3.75e-06199143730d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellParenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6 PCDH18

3.87e-0620014370c648941447c738caf62f2d71e296d6cca492c8b
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6 PCDH18

3.87e-062001437522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6 PCDH18

3.87e-06200143794f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCelldistal-mesenchymal-Pericyte-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRCAM INPP4B SEMA6D GPR158 COL21A1 INSC PCDH18

3.87e-062001437867935701fac71a3fe01578362da0676f959736c
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST|Neuronal / cells hierarchy compared to all cells using T-Statistic

PREX2 INPP4B ADRA1A SEMA6D COL21A1 SCN5A PCDH18

3.87e-06200143753d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCelldistal-2-mesenchymal-Pericyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRCAM INPP4B SEMA6D GPR158 COL21A1 INSC PCDH18

3.87e-0620014374ee0b2f56c2652435fa78bf6b3c90cea28df74e0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MBOAT4 PREX2 GJA1 SLC7A4 TM4SF18 DOCK6

1.46e-05163143673c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SLC43A2 BNC2 DPY19L2 ITPR2 SIMC1 DOCK6

1.57e-0516514365cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1F LYST INPP4B ITPR2 DNAAF5 TAF5L

1.73e-05168143619d2c763b50e7168dfa7449fc407489b055526c2
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-mature_NK_T_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1F LYST INPP4B ITPR2 DNAAF5 TAF5L

1.73e-051681436fa198bd53b2d640d9a8684783bf5ca23314caae2
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN14 CXCL10 MPDU1 TMEM119 ADCY8 INSC

1.85e-051701436b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

INPP4B ADRA1A COL21A1 SCN5A PCDH10 PCDH18

2.05e-0517314360ba64e5385fe714f876002520f8b5202809bf11e
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D SLC4A7 SREBF2 F8 PIK3C2A GPR158

2.11e-051741436f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC43A2 DPY19L2 INPP4A ABCC5 ITPR1 ITPR2

2.18e-05175143677c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTGER2 PREX2 ADRA1A COL21A1 SCN5A CCL1

2.26e-05176143623f930dac5247ea6d4124da33933d61ad6e089af
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OR7A5 PREX2 LMOD3 ADRA1A COL21A1 PCDH18

2.33e-051771436fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN14 SLC4A7 SLC4A8 NRCAM SEMA6D GPC3

2.40e-0517814364df6218b20c2f076c22346d23260964cc0d73e65
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

2.56e-05180143608ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN14 SLC4A7 SLC4A8 NRCAM ABCC5 SEMA6D

2.56e-0518014369e09b3dfe344b5d50520711513d389865d73a861
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

2.56e-0518014369b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellMatrixFB-Fibroblast-A|MatrixFB / shred on cell class and cell subclass (v4)

CACNA1D NRCAM TMEM119 PTGER2 PREX2 GPC3

2.56e-051801436adc64ad6033af705dd7b9163a83e20ef5c59f6eb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

INPP4B ADRA1A COL21A1 SCN5A PCDH10 PCDH18

2.56e-051801436b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellcritical-Lymphoid-NK|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

BNC2 NRCAM OR7A5 GJA1 TM4SF18 MEGF10

2.56e-0518014365abf778395392244daaec876f306ed7e4f388686
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

2.64e-0518114369e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D NRCAM TMEM119 PTGER2 ADRA1A GPC3

2.72e-051821436c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCellP28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D NRCAM TMEM119 PREX2 ADRA1A GPC3

2.72e-05182143619c5e3a9d9b3728303b682102e276adfe93aa759
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D NRCAM TMEM119 PTGER2 ADRA1A GPC3

2.72e-051821436dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

SLC43A2 ARMC7 DPY19L2 INPP4A ABCC5 ITPR2

2.81e-0518314365c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA CACNA1F NRCAM MUC5B PCDH10 ANO3

2.90e-0518414362cbed6462fea2622871bb7e49b0df3d984239281
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D NRCAM TMEM119 PREX2 ADRA1A GPC3

2.90e-051841436924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA CACNA1F NRCAM MUC5B PCDH10 ANO3

2.90e-051841436ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA CACNA1F NRCAM MUC5B PCDH10 ANO3

2.90e-0518414362b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

BNC2 SLC4A8 HACD4 CLDN15 GPC3 INSC

2.90e-051841436607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

INPP4B ADRA1A COL21A1 SCN5A PCDH10 PCDH18

2.98e-05185143616e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PREX2 INPP4B ADRA1A COL21A1 SCN5A PCDH18

2.98e-051851436027020754dbf71b0034791f9a34ae795e3b85f81
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PREX2 INPP4B ADRA1A SEMA6D COL21A1 PCDH10

2.98e-051851436487fa382232564f075960899d50afa0edae5d258
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D CLDN14 SLC4A7 SLC4A8 NRCAM SEMA6D

2.98e-05185143603f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 INPP4B SEMA6D DOCK6 PCDH18

3.08e-051861436888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D CLDN14 SLC4A7 SLC4A8 NRCAM SEMA6D

3.08e-0518614361850583d23903d08226aeb0edb3e07b0994330e4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1D CLDN14 SLC4A7 SLC4A8 NRCAM SEMA6D

3.08e-0518614364dafc215c42e7949f932a3627359c107943b5d6b
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

CACNA1D BNC2 ADRA1A GPC3 COL21A1 ANO3

3.17e-05187143692d468dde81125d51daf7abd4703741abe1ab91c
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NRCAM PREX2 INPP4B SEMA6D DOCK6 PCDH18

3.17e-051871436a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6

3.27e-051881436ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

NRCAM PREX2 INPP4B SEMA6D DOCK6 PCDH18

3.36e-051891436d7ed96add29f219183c802895fbff519b627f635
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6

3.46e-0519014364eb92aef1ee868f4537483d19014d947b7684612
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CLDN14 SLC22A25 ABCC6 GPC3 SLC45A3 SLC17A1

3.46e-051901436b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NRCAM PREX2 INPP4B SEMA6D INSC DOCK6

3.46e-0519014367be4341e2909101d756f14031c21e705eb45e69a
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

3.57e-051911436b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1D NRCAM TMEM119 PREX2 ADRA1A GPC3

3.57e-051911436beb5bb42bd53bce01339da9110d374901548793c
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1D NRCAM TMEM119 PREX2 ADRA1A GPC3

3.57e-0519114366609d85fd2577633dcc067507304a6f9e5865ca3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PREX2 ADCY8 INPP4B ADRA1A COL21A1 PCDH18

3.57e-0519114367b386512284dfaa0e95358b28ee82632ee965e64
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

INPP4B ADRA1A SEMA6D GPR137C INSC KCNT1

3.57e-05191143672f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

F8 PREX2 GJA1 DNM3 TM4SF18 DOCK6

3.57e-0519114362f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

INPP4B ADRA1A SEMA6D GPR137C INSC KCNT1

3.57e-0519114366e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PREX2 ADCY8 INPP4B ADRA1A COL21A1 PCDH18

3.57e-051911436fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCelldroplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP4B ADRA1A SEMA6D GPR137C INSC KCNT1

3.57e-0519114363ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CACNA1D BNC2 ADRA1A GPC3 COL21A1 ANO3

3.57e-0519114366688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

3.67e-0519214366f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

3.67e-051921436dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1D NRCAM TMEM119 PTGER2 PREX2 GPC3

3.67e-0519214360afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

3.67e-051921436deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 SEMA6D GPR158 INSC PCDH18

3.78e-051931436b2abe939027a69b60d83a28d4d4cc53ba1dee4c5
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 SEMA6D GPR158 INSC PCDH18

3.78e-051931436d75f334fe3d9f39ef02a5de0f8202f7a761a8fc8
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1D BNC2 PREX2 ADRA1A GPC3 COL21A1

3.78e-05193143699525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

3.78e-051931436fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 SEMA6D GPR158 INSC PCDH18

3.78e-05193143641ea268e7697101fe70d8ef1045f3a43b9311739
ToppCellCOVID-19-kidney-Glomerular_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SYNE1 F8 PREX2 PIK3C2A DNM3 TM4SF18

3.89e-051941436660535b492445063d965095a50e1e299ce04c50a
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRCAM PREX2 SEMA6D GPR158 INSC PCDH18

3.89e-0519414363cffb5c58f6d5bd254f39ee9c41b7e1e4da0ff75
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 F8 PREX2 DNM3 TM4SF18 DOCK6

3.89e-051941436a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

CACNA1D BNC2 INPP4B ADRA1A GPC3 COL21A1

4.01e-05195143661c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D122|Adult / Lineage, Cell type, age group and donor

CACNA1D BNC2 ADRA1A GPC3 COL21A1 ANO3

4.01e-051951436aa0add081881d349099d12efca5cdee098038d4e
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D NRCAM TMEM119 PTGER2 PREX2 GPC3

4.12e-0519614362a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCellNon-neuronal-Dividing-Radial_Glia-early|World / Primary Cells by Cluster

BNC2 TMEM119 GJA1 GPC3 CMTM7 PCDH18

4.12e-051961436dd3c6ea5e4ebcc27064f16507de6db6dc8f86fa8
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1D NRCAM TMEM119 PTGER2 PREX2 GPC3

4.12e-05196143614246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellNon-neuronal-Dividing-Radial_Glia-early-1|World / Primary Cells by Cluster

BNC2 TMEM119 GJA1 GPC3 CMTM7 PCDH18

4.12e-05196143670fe6a1a6de891832aaa6276c985b326985e14db
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 F8 PREX2 PIK3C2A DNM3 DOCK6

4.36e-0519814361378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellCOVID-19-lung-Fibroblast|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1D BNC2 NRCAM ADRA1A GPC3 COL21A1

4.36e-0519814363ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 F8 PREX2 PIK3C2A DNM3 DOCK6

4.36e-051981436451003a21162eeae90739fdb502bb50b362d80c8
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1D NRCAM SYNE1 ITPR1 GPR158 SLC4A10

4.36e-0519814364ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

CACNA1D BNC2 NRCAM INPP4B ADRA1A GPC3

4.36e-051981436df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 F8 PREX2 PIK3C2A DNM3 DOCK6

4.36e-051981436440af8f90c7afa1c07000806bcf9110b70f489fb
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR1 ITPR2 ITPR3

2.04e-05121363DOID:1441 (implicated_via_orthology)
DiseaseHypoxic Brain Damage

ITPR1 ITPR2

2.11e-0521362C1140716
DiseaseAnoxic Encephalopathy

ITPR1 ITPR2

2.11e-0521362C0003132
DiseaseBrain Hypoxia

ITPR1 ITPR2

2.11e-0521362C1527348
DiseaseAnoxia of brain

ITPR1 ITPR2

2.11e-0521362C0995195
Diseaseanemia (implicated_via_orthology)

SLC4A7 SLC4A8 SLC4A10

4.18e-05151363DOID:2355 (implicated_via_orthology)
DiseaseFrontal Epilepsy, Benign, Childhood

SLC4A10 KCNT1

1.26e-0441362C0393671
DiseaseEpilepsy, Cingulate

SLC4A10 KCNT1

1.26e-0441362C0393684
DiseaseEpilepsy, Supplementary Motor

SLC4A10 KCNT1

1.26e-0441362C0393683
DiseaseEpilepsy, Opercular

SLC4A10 KCNT1

1.26e-0441362C0393688
DiseaseBrugada ECG Pattern

SCN5A SCN10A

1.26e-0441362C1721096
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1D CACNA1F

1.26e-0441362DOID:0060173 (implicated_via_orthology)
DiseaseHeart Block

CACNA1D SCN10A

1.26e-0441362C0018794
DiseaseEpilepsy, Orbito-Frontal

SLC4A10 KCNT1

1.26e-0441362C0751643
DiseaseEpilepsy, Anterior Fronto-Polar

SLC4A10 KCNT1

1.26e-0441362C0751642
DiseaseEpilepsy, Frontal Lobe

SLC4A10 KCNT1

1.26e-0441362C0085541
DiseaseAuriculo-Ventricular Dissociation

CACNA1D SCN10A

1.26e-0441362C0004331
Diseasecerebellar ataxia (is_implicated_in)

SYNE1 POLG

2.09e-0451362DOID:0050753 (is_implicated_in)
DiseaseSick Sinus Syndrome

CACNA1D SCN5A

3.13e-0461362C0037052
Diseasecytotoxicity measurement, response to clozapine

CXCL10 TMCC3 CCL1

3.21e-04291363EFO_0006952, GO_0097338
Diseaseelectrocardiography, PR interval

SCN5A SCN10A

4.36e-0471362EFO_0004327, EFO_0004462
Diseasearrhythmogenic right ventricular cardiomyopathy (is_marker_for)

GJA1 SCN5A

4.36e-0471362DOID:0050431 (is_marker_for)
Disease6-bromotryptophan measurement

GPR137C SLC17A1

7.43e-0491362EFO_0800099
Diseasesupraventricular ectopy

SCN5A SCN10A

7.43e-0491362EFO_0009277
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN5A SCN10A

9.26e-04101362DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN5A SCN10A

9.26e-04101362DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN5A SCN10A

1.35e-03121362DOID:0060170 (implicated_via_orthology)
DiseaseBrugada Syndrome 1

SCN5A SCN10A

1.59e-03131362C4551804
Diseasesusceptibility to bacterial meningitis measurement

CACNA1D DPY19L2 INPP4B

1.79e-03521363EFO_0008411
DiseaseT wave morphology measurement

SCN5A SCN10A

1.85e-03141362EFO_0008398
Diseaseplatelet storage pool deficiency (implicated_via_orthology)

LYST HPS3

2.13e-03151362DOID:2223 (implicated_via_orthology)
DiseaseHypogonadotropic hypogonadism

SLC29A3 GNRHR

2.13e-03151362C0271623
DiseaseP wave duration

SCN5A SCN10A

2.13e-03151362EFO_0005094
DiseasePrimary hypogonadism

SLC29A3 GNRHR

2.13e-03151362C0948896
DiseaseHypogonadism, Isolated Hypogonadotropic

SLC29A3 GNRHR

2.13e-03151362C3489396
DiseaseSinus Node Dysfunction (disorder)

CACNA1D SCN10A

2.13e-03151362C0428908
DiseaseRomano-Ward Syndrome

SCN5A SCN10A

2.43e-03161362C0035828
DiseaseHypogonadism

SLC29A3 GNRHR

2.43e-03161362C0020619
Diseaseobesity (implicated_via_orthology)

ITPR1 ITPR2 ITPR3 GNRHR MED12

3.26e-032151365DOID:9970 (implicated_via_orthology)
DiseaseBrugada syndrome

SCN5A SCN10A

3.43e-03191362MONDO_0015263
Diseasethrombin activatable fibrinolysis inhibitor activation peptide measurement

OTOA ITPR1

3.43e-03191362EFO_0008582
Diseasediabetic retinopathy

INPP4B OR6N1 GPR158 IL26

3.68e-031361364EFO_0003770
Diseasetype 2 diabetes mellitus (is_marker_for)

CACNA1D CXCL10 F8 PIK3C2A

3.68e-031361364DOID:9352 (is_marker_for)
DiseaseDeaf Mutism

CACNA1D CLDN14

3.79e-03201362C4082305
DiseaseDeafness, Acquired

CACNA1D CLDN14

3.79e-03201362C0751068
DiseaseHearing Loss, Extreme

CACNA1D CLDN14

3.79e-03201362C0086395
DiseaseComplete Hearing Loss

CACNA1D CLDN14

3.79e-03201362C0581883
DiseaseBilateral Deafness

CACNA1D CLDN14

3.79e-03201362C3665473
DiseasePrelingual Deafness

CACNA1D CLDN14

3.79e-03201362C0011052
Diseasegestational age, birth measurement

SLC29A3 INSC

4.18e-03211362EFO_0005112, EFO_0006921
Diseasenephrosis (biomarker_via_orthology)

SREBF2 CCL1

4.59e-03221362DOID:2527 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
LEMSCAIQNQLARIL

BARGIN

106

Q6ZT62
VLAMVTCAVFLRLNS

ADCY8

841

P40145
MQIITTALVCLLLAG

CCL1

1

P22362
TNLLFRMSQQAIRCT

BNC2

101

Q6ZN30
MASLIQRIARQACLT

ADO

6

Q96SZ5
VLDRVCFLAMLSLFI

CHRNG

471

P07510
TIVTQRRGLMALLCV

ADRA1A

136

P35348
NVSMFIVVLVQLCRI

ADGRG2

801

Q8IZP9
VMLVTLCNTLARGLI

CFAP46

781

Q8IYW2
ICAMNTVLLSLLFSL

SLC7A4

326

O43246
SLLLVCILQFFNSMI

DPY19L3

296

Q6ZPD9
LVNLCISMLIFNLLF

ADGRG7

471

Q96K78
IVQCELLMLRVLRFQ

CCNQ

121

Q8N1B3
LMNLTFLDLTRCQIN

CD180

76

Q99467
SAAAVCINFIIIMLL

ANO3

596

Q9BYT9
ACRTLVLALAAMLVV

MUC5B

6

Q9HC84
FQRTVILLATFCMVS

NDST3

11

O95803
LSIMNRRVCTLLVFT

OR6C1

131

Q96RD1
ARMLASQNIVIILCG

RAB4A

111

P20338
TLLMCIVTVLNQGLR

ITPR2

2481

Q14571
ISQQLGVDLIFLCMA

ITPR3

751

Q14573
QCFNTLERSEMLLLL

INTS10

121

Q9NVR2
RTAMSVTLEQCLILQ

INPP4A

901

Q96PE3
AVLLVIMVLFATRCN

PCDH18

711

Q9HCL0
SLLQILMVVRLSFCT

OR7A5

156

Q15622
LLTMCRNLITFLRET

DUOX1

1101

Q9NRD9
MVISLNSCLSFICLL

MEGF10

1

Q96KG7
LITLERCFQMLNSLE

OTOA

161

Q7RTW8
QCVFVAIRTIGNIMI

CACNA1F

991

O60840
LMTVLGNLLIFLVVC

OR6N1

36

Q8NGY5
LLLLLMAAVVRCQEQ

PLA2G12A

11

Q9BZM1
FARLQTCISELRMLQ

M1AP

86

Q8TC57
RVPLILFLCQMISAL

NRCAM

16

Q92823
ITIMQPILRFLQLLC

ITPR1

1971

Q14643
AIGLVMRLCQSVSLL

HACD4

56

Q5VWC8
GIVAIMRCLQFNETL

LMOD3

326

Q0VAK6
RTACLVVAMLLSLDF

GPC3

6

P51654
LRLAIISFQALCMLL

GPR158

416

Q5T848
QRRLIALLMAFVCSL

MMS19

711

Q96T76
LSLVTMCVTQLRLIF

SLC43A2

326

Q8N370
QCLMLTLRRDIVFSQ

INPP4B

616

O15327
IMASLLFLVVNLTCA

GPR137C

171

Q8N3F9
SAMFNQVLILFCTLL

KCNT1

246

Q5JUK3
LLGFLIITLNCNVTM

GJD4

6

Q96KN9
MQFITRENCLILAVT

DNM3

161

Q9UQ16
FNLMNIICTRVRNSL

KIAA1586

711

Q9HCI6
LCFTTSIIPQMLVNL

OR2W1

71

Q9Y3N9
NSMILFVVLCERSLH

OR51F2

56

Q8NH61
TEIRLQLLTFSAMCQ

PIK3C2A

501

O00443
VLACNFSVILNLIRM

PTGER2

211

P43116
STCMLVVLLRVQLNI

PEX3

121

P56589
LTCLIIIMQNRLSVP

ENPP4

421

Q9Y6X5
LALQITNLLTRCMFA

POLG

1151

P54098
VLSSAQAQRLMQLIC

MED12

1311

Q93074
MQIELSTCFFLCLLR

F8

1

P00451
LTATPVVQCMLRFSL

ARMC7

136

Q9H6L4
TTIMSSRICIQLIFC

OR2AP1

131

Q8NGE2
SFIFLLAMIVLAVRC

PCDH10

726

Q9P2E7
LVLQMCILTLILRTS

DPY19L2

306

Q6NUT2
TVIMNSRACLLLVLG

OR6M1

131

Q8NGM8
LTIMSSRVCIQLVFC

OR6C4

131

Q8NGE1
LLQLTCVSCVRAVMN

INF2

96

Q27J81
RLCLLIFSIFLMAVS

OR2T10

26

Q8NGZ9
IMTNELCIQLLVLSF

OR5H6

151

Q8NGV6
RTRLILSIVCLMITQ

ABCC5

176

O15440
IVRRFTLSVLKCLQM

DYRK4

206

Q9NR20
MRSVQIFLSQCRLLL

ADAM30

1

Q9UKF2
CIIGNMISLFQIESL

CKAP5

1616

Q14008
NVLLSLRITVSAMCF

GABRR3

171

A8MPY1
ALLTLRMEFTRILCS

DOCK6

1036

Q96HP0
IMLICNAKIIFTLTR

GNRHR

226

P30968
ATQCFATLIRLMPLE

BTAF1

1206

O14981
DLQAARALMVISCLL

CLDN14

76

O95500
EMQAQCTLINFLVTR

DNAH17

3541

Q9UFH2
MNQTAILICCLIFLT

CXCL10

1

P02778
IFMLVVSLVSLALNI

GJA1

211

P17302
LVTNMLRLRAICPFS

FASTKD1

11

Q53R41
MLVNFILRCGLLLVT

IL26

1

Q9NPH9
TFLCMVLVLLLQNSV

COL21A1

6

Q96P44
ICFLSMLQVIFRRIN

DPY19L4

431

Q7Z388
QACRALMITAILLGF

CLDN15

76

P56746
ACQRVLVDLLVSLMS

LYST

1336

Q99698
LSQVSVLMRNICATL

FBXO40

596

Q9UH90
FCITLSSLMLLTQRV

MBOAT4

116

Q96T53
ACEMLLQLNAIRVLL

INSC

406

Q1MX18
VILHLTVLLFNRCMV

AHCTF1

876

Q8WYP5
MTRLISCRIINTFLK

DNAAF5

716

Q86Y56
SSVCLLVIVGLLMFR

HBEGF

171

Q99075
VFRMSLLIISTFLLC

GPR22

311

Q99680
SLILNIMCAALNLIR

SEC22C

191

Q9BRL7
LAFVIRDQCILQLVM

SLC22A25

251

Q6T423
QCVFVAIRTIGNIMI

CACNA1D

1006

Q01668
FVIAACQLVLGLLMT

LRRN1

6

Q6UXK5
GNLLIMVTVTFDCRL

OR4D1

41

Q15615
SNNGLVTLMCFLVLL

OR4D5

201

Q8NGN0
FLLLIMSCARIVSTI

OR1E3

211

Q8WZA6
TRELLQPMVSFLLLC

PCARE

211

A6NGG8
LTILRLSFCTNMEIP

OR7C2

161

O60412
LLASMAIDRLVAICN

OR1L6

151

Q8NGR2
LTIMNRQVCFLLLVV

OR4A5

131

Q8NH83
LTIMNRQVCILLLVV

OR4A8

131

P0C604
DMILISLGISRFCLQ

TAS2R16

46

Q9NYV7
MILISLGASRFCLQL

TAS2R41

46

P59536
VLSVQFMACNLLLVT

TAF5L

566

O75529
MLCLVANFLLVNRVA

SLC29A3

116

Q9BZD2
LLCTILIFMDQQITA

SLC4A7

921

Q9Y6M7
VSCLNTSLVILMLAR

TRPC4AP

686

Q8TEL6
LGRCINVILAFMTVI

TMCC3

411

Q9ULS5
QLRVASLQDMSCQLL

SYNE1

8606

Q8NF91
CGALIMEQFIIRNTL

TMEM229B

126

Q8NBD8
SMDVCALRIQLFIGL

HPS3

421

Q969F9
LLAVLMFLSACLQTL

ABCC6

351

O95255
VIITAQRACLNLTMV

SLC17A1

31

Q14916
IFCLDMQQVTLVLLG

MED24

771

O75448
VAMLLCTGLVVQAQR

RNF215

261

Q9Y6U7
GQSLCLLVFLLVMVI

SCN5A

911

Q14524
QLIVCQLQRMLSIAV

SIMC1

661

Q8NDZ2
LMQQTLRTVAFLCET

SLC9A8

346

Q9Y2E8
LLCTILIFMDQQITA

SLC4A8

791

Q2Y0W8
TRVLMDIVANILCII

ABCC12

121

Q96J65
ALFLMLQTITICFLV

MPDU1

106

O75352
QCAISLVFSLVMDRL

SLC45A3

331

Q96JT2
FVLTANTCILARVVM

ADGRD2

811

Q7Z7M1
AQMVTLLIAFICVRS

CMTM7

51

Q96FZ5
VLRFAVSCRILTLML

PIGV

11

Q9NUD9
VSCRILTLMLQALFN

PIGV

16

Q9NUD9
FLMTCISLRNLILGR

GGCX

696

P38435
ILCVTLALMLQRDSA

YIPF6

96

Q96EC8
LFVMISSAAQLLICL

TAS1R1

681

Q7RTX1
LQVIICLIRVVMQLS

TM4SF18

171

Q96CE8
MTLRQAFAILLSCLL

SLC35B2

371

Q8TB61
CLILFLTVMVLGNLV

SCN10A

866

Q9Y5Y9
ALLCTILIFMDQQIT

SLC4A10

821

Q6U841
MVDRSRILLCVLTFL

SREBF2

476

Q12772
QCLREQSMLLEIIFL

NUP188

206

Q5SRE5
LLLLQDTEMQRICSF

PPP1R36

126

Q96LQ0
LNKIRTIRTFLLNCM

PREX2

136

Q70Z35
CLMIIIVGTRIQFSD

TLR6

16

Q9Y2C9
INELCLLQRAVNIFM

TOPAZ1

1136

Q8N9V7
TTLCVSILERLLQAM

PSMD5

61

Q16401
LVIARICLISVMVVN

TAS2R8

51

Q9NYW2
CIYMLSTNILLVNLL

TRPM8

961

Q7Z2W7
LCAYILLLMVSQLRA

SEMA6D

6

Q8NFY4
GQTELILLLMCFILA

TSBP1

96

Q5SRN2
FLLMFIVCAAVITRQ

TMEM119

106

Q4V9L6
MHTLVFLSTRQVLQC

LRRC14

1

Q15048