Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of RNA splicing

PTBP3 PTBP2 AHNAK POLR2A

2.70e-05207184GO:0043484
DomainDUF846_euk

TVP23C TVP23B

4.67e-064172IPR008564
DomainDUF846

TVP23C TVP23B

4.67e-064172PF05832
DomainHnRNP-L/PTB

PTBP3 PTBP2

7.79e-065172IPR006536
DomainRRM_1

PTBP3 PTBP2

1.50e-02208172PF00076
DomainRRM

PTBP3 PTBP2

1.63e-02217172SM00360
DomainRRM_dom

PTBP3 PTBP2

1.77e-02227172IPR000504
DomainRRM

PTBP3 PTBP2

1.82e-02230172PS50102
Domain-

PTBP3 PTBP2

2.03e-022441723.30.70.330
DomainNucleotide-bd_a/b_plait

PTBP3 PTBP2

2.26e-02258172IPR012677
Pubmed

Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.

PTBP3 PTBP2

2.53e-07218226657638
Pubmed

Expression of human nPTB is limited by extreme suboptimal codon content.

PTBP3 PTBP2

7.59e-07318218335065
Pubmed

PTBP1 is required for embryonic development before gastrulation.

PTBP3 PTBP2

2.53e-06518221423341
Pubmed

Polypyrimidine tract-binding proteins are essential for B cell development.

PTBP3 PTBP2

2.53e-06518232081131
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

OSBPL8 TVP23C AHNAK TVP23B GBF1 EHD4

5.80e-0695218638569033
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

NOLC1 PTBP3 PTBP2 AHNAK EHD4

9.23e-0658218520467437
Pubmed

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

MAML1 POLR2A

1.39e-051118215546612
Pubmed

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

NKX3-2 POLR2A

3.42e-051718232155439
Pubmed

Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.

PTBP3 PTBP2

1.24e-043218236252997
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

PTBP2 AHNAK EHD4

1.50e-0420318322083510
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

POLR2A GBF1

1.95e-044018223825951
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

OSBPL8 NOLC1 AHNAK POLR2A

3.06e-0465318422586326
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

NOLC1 POLR2A

3.30e-045218224591637
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

OSBPL8 PTBP3 PTBP2 POLR2A

4.00e-0470118430196744
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

NOLC1 PTBP3 PTBP2 POLR2A

4.49e-0472318434133714
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NOLC1 MICAL2 AHNAK POLR2A EHD4

4.96e-04135318529467282
CytobandEnsembl 112 genes in cytogenetic band chr10q24

NOLC1 GBF1

2.47e-03189182chr10q24
GeneFamilyRNA binding motif containing

PTBP3 PTBP2

8.44e-03213122725
CoexpressionAMIT_EGF_RESPONSE_240_MCF10A

MICAL2 EHD4

9.28e-0521182M2894
CoexpressionFORTSCHEGGER_PHF8_TARGETS_DN

TVP23C PTBP3 MICAL2 AHNAK TVP23B

1.46e-04783185M2488
CoexpressionGSE3565_DUSP1_VS_WT_SPLENOCYTES_UP

PTBP2 MICAL2 AHNAK

1.80e-04163183M6329
CoexpressionSIMBULAN_UV_RESPONSE_NORMAL_DN

AHNAK POLR2A

2.32e-0433182M16114
CoexpressionGSE37533_PPARG1_FOXP3_VS_PPARG2_FOXP3_TRANSDUCED_CD4_TCELL_PIOGLITAZONE_TREATED_UP

NOLC1 MICAL2 EHD4

3.09e-04196183M8970
CoexpressionGSE41867_DAY8_EFFECTOR_VS_DAY30_EXHAUSTED_CD8_TCELL_LCMV_CLONE13_UP

AHNAK TVP23B EML5

3.23e-04199183M9491
CoexpressionGSE26669_CD4_VS_CD8_TCELL_IN_MLR_DN

OSBPL8 AHNAK GBF1

3.23e-04199183M4670
CoexpressionGSE11057_NAIVE_VS_CENT_MEMORY_CD4_TCELL_DN

MICAL2 AHNAK EHD4

3.23e-04199183M3107
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_DN

MAML1 AHNAK EHD4

3.28e-04200183M5980
CoexpressionGSE360_CTRL_VS_T_GONDII_MAC_UP

HTR7 AHNAK GBF1

3.28e-04200183M5162
CoexpressionGSE4748_CTRL_VS_LPS_STIM_DC_3H_UP

MAML1 AHNAK POLR2A

3.28e-04200183M6480
CoexpressionFIGUEROA_AML_METHYLATION_CLUSTER_3_DN

MAML1 AHNAK

3.42e-0440182M2169
Diseaselymphocyte:monocyte ratio

AHNAK EHD4 ZNF483

5.65e-04288173EFO_0600088
DiseaseHeadache

PTBP2 MYO1H

6.17e-0464172HP_0002315
DiseaseAlzheimer disease, age at onset

HTR7 MICAL2 AHNAK

9.38e-04343173EFO_0004847, MONDO_0004975
Diseasesocial interaction measurement

PTBP2 MYO1H

1.32e-0394172EFO_0009592
Diseaseresting heart rate

MAML1 MICAL2

3.28e-03149172EFO_0004351
Diseaseanthropometric measurement

MYO1H POLR2A

4.14e-03168172EFO_0004302
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

MYO1H GBF1

5.81e-03200172EFO_0004611, EFO_0020945
Diseaseneutrophil count, eosinophil count

MAML1 EHD4

6.57e-03213172EFO_0004833, EFO_0004842
Diseaseneutrophil count, basophil count

MAML1 EHD4

7.24e-03224172EFO_0004833, EFO_0005090
Diseasemonocyte percentage of leukocytes

MAML1 AHNAK EHD4

7.95e-03731173EFO_0007989
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

NOLC1 AHNAK

8.20e-03239172EFO_0010934
Diseasegranulocyte count

MAML1 EHD4

9.22e-03254172EFO_0007987
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

MYO1H GBF1

1.07e-02274172EFO_0004530, EFO_0004612
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

MYO1H GBF1

1.08e-02276172EFO_0004612, EFO_0020943

Protein segments in the cluster

PeptideGeneStartEntry
GKFSLFKSKKPRHRS

AHNAK

5766

Q09666
FPKRKKGEKRASSPF

NOLC1

611

Q14978
AKAKRAGKHRQPPAA

MAML1

66

Q92585
FPKPGRVHHASEKKR

FAM124A

286

Q86V42
PKKPFRKLSRFGNAF

EHD4

121

Q9H223
RPSKKDGFCFKLFHP

OSBPL8

201

Q9BZF1
APKPRKKRSRAAFSH

NKX3-2

201

P78367
GADKKFARKPPRFSC

GBF1

671

Q92538
PEKFAKHKRFLGHSP

EML5

1921

Q05BV3
ARKEKKSPSGFHFHP

MICAL2

926

O94851
FGNSPLHRFKKPGSK

PTBP2

431

Q9UKA9
ARKSAAKHKFPGFPR

HTR7

266

P34969
PRKAKIRHPVASFFH

TVP23C

26

Q96ET8
KRIPFGFKHRTLPHF

POLR2A

796

P24928
FSNSPLHRFKKPGSK

PTBP3

451

O95758
RGKKFDPDKSPFGHN

ZNF483

296

Q8TF39
PRKAKIRHPVASFFH

TVP23B

26

Q9NYZ1
AHFETRKLAGPKGRK

MYO1H

491

Q8N1T3