Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionzinc ion binding

TET2 UBR5 LNPEP POLA1 RBM4B IGHMBP2 OTUD7A WT1 GATA5 MDM4 NR1D1 CBLB USP16 MNAT1 PGR

1.30e-058919215GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

TET2 RPLP2 UBR5 LNPEP POLA1 RBM4B IGHMBP2 OTUD7A WT1 GATA5 MDM4 ADNP NR1D1 CBLB USP16 MNAT1 PGR

2.67e-0511899217GO:0046914
GeneOntologyMolecularFunctiontranscription coregulator binding

MED1 BSN SIX1 NR1D1 TP73 PGR

4.64e-05140926GO:0001221
GeneOntologyCellularComponentchromatin

NCOR1 ATF6 ARNT SCML2 HOXD1 ZBED4 UBR5 POLA1 ARNT2 GATA5 SIM1 MED1 SIX1 ADNP NR1D1 TP73 PGR

2.94e-0414809417GO:0000785
GeneOntologyCellularComponentneuronal cell body

CNTNAP3B MYO5B LNPEP IGHMBP2 NUMA1 CNTNAP3 IGSF9B BSN ADNP NR1D1 GABBR1 PGR

3.60e-048359412GO:0043025
GeneOntologyCellularComponentaryl hydrocarbon receptor complex

ARNT ARNT2

5.50e-048942GO:0034751
GeneOntologyCellularComponentaxon

CNTNAP3B NF1 USP9X IGHMBP2 CNTN5 CNTNAP3 ADGRL1 BSN ADNP GABBR1 PGR JAM2

6.41e-048919412GO:0030424
GeneOntologyCellularComponentcell body

CNTNAP3B MYO5B LNPEP IGHMBP2 NUMA1 CNTNAP3 IGSF9B BSN ADNP NR1D1 GABBR1 PGR

9.23e-049299412GO:0044297
GeneOntologyCellularComponentinsulin-responsive compartment

LNPEP DENND4C

1.07e-0311942GO:0032593
GeneOntologyCellularComponentcell cortex region

MYO5B NUMA1 BSN

1.09e-0345943GO:0099738
GeneOntologyCellularComponentsomatodendritic compartment

CNTNAP3B NF1 MYO5B LNPEP IGHMBP2 NUMA1 CNTNAP3 IGSF9B BSN ADNP NR1D1 GABBR1 PGR JAM2

1.15e-0312289414GO:0036477
GeneOntologyCellularComponenttranscription regulator complex

NCOR1 ATF6 ARNT ARNT2 MED1 SIX1 MDM4 ADNP MNAT1

1.45e-03596949GO:0005667
DomainKH_1

ANKHD1 MEX3B NOVA1 NOVA2

3.58e-0538924PF00013
DomainKH

ANKHD1 MEX3B NOVA1 NOVA2

4.40e-0540924SM00322
DomainKH_dom

ANKHD1 MEX3B NOVA1 NOVA2

4.40e-0540924IPR004087
DomainKH_TYPE_1

ANKHD1 MEX3B NOVA1 NOVA2

5.35e-0542924PS50084
DomainKH_dom_type_1

ANKHD1 MEX3B NOVA1 NOVA2

6.44e-0544924IPR004088
DomainPAS_fold_3

ARNT ARNT2 SIM1

1.91e-0423923IPR013655
DomainPAS_3

ARNT ARNT2 SIM1

1.91e-0423923PF08447
DomainPAS-assoc_C

ARNT ARNT2 SIM1

2.17e-0424923IPR000700
DomainPAS

ARNT ARNT2 SIM1

2.46e-0425923PF00989
DomainPAS_fold

ARNT ARNT2 SIM1

2.46e-0425923IPR013767
DomainPAC

ARNT ARNT2 SIM1

2.77e-0426923IPR001610
DomainPAC

ARNT ARNT2 SIM1

2.77e-0426923SM00086
DomainPAC

ARNT ARNT2 SIM1

2.77e-0426923PS50113
DomainPAS

ARNT ARNT2 SIM1

5.17e-0432923SM00091
DomainPAS

ARNT ARNT2 SIM1

6.20e-0434923IPR000014
DomainPAS

ARNT ARNT2 SIM1

6.20e-0434923PS50112
DomainNuc_translocat

ARNT ARNT2

6.59e-048922IPR001067
DomainLAM_G_DOMAIN

CNTNAP3B CSPG4 CNTNAP3

8.61e-0438923PS50025
Domain-

MEX3B NOVA1 NOVA2

9.30e-04399233.30.1370.10
DomainLaminin_G_2

CNTNAP3B CSPG4 CNTNAP3

1.00e-0340923PF02210
DomainLamG

CNTNAP3B CSPG4 CNTNAP3

1.32e-0344923SM00282
Domain-

GATA5 NR1D1 PGR

2.79e-03579233.30.50.10
DomainLaminin_G

CNTNAP3B CSPG4 CNTNAP3

2.93e-0358923IPR001791
DomainZnf_NHR/GATA

GATA5 NR1D1 PGR

2.93e-0358923IPR013088
DomainUSP_CS

USP2 USP9X USP16

4.23e-0366923IPR018200
DomainFA58C

CNTNAP3B CNTNAP3

4.74e-0321922SM00231
DomainFA58C_3

CNTNAP3B CNTNAP3

4.74e-0321922PS50022
DomainFA58C_1

CNTNAP3B CNTNAP3

4.74e-0321922PS01285
DomainFA58C_2

CNTNAP3B CNTNAP3

4.74e-0321922PS01286
Domain-

NF1 USP9X NCAPD2 FRYL BRAT1

4.83e-032229251.25.10.10
DomainUSP_1

USP2 USP9X USP16

4.99e-0370923PS00972
DomainUCH

USP2 USP9X USP16

5.19e-0371923PF00443
DomainUSP_2

USP2 USP9X USP16

5.19e-0371923PS00973
DomainUSP_3

USP2 USP9X USP16

5.40e-0372923PS50235
DomainUSP_dom

USP2 USP9X USP16

5.40e-0372923IPR028889
DomainPeptidase_C19_UCH

USP2 USP9X USP16

5.40e-0372923IPR001394
DomainF5_F8_type_C

CNTNAP3B CNTNAP3

6.17e-0324922PF00754
DomainFA58C

CNTNAP3B CNTNAP3

6.17e-0324922IPR000421
DomainARM-type_fold

NF1 USP9X NCAPD2 FRYL BRAT1 UNC79

6.60e-03339926IPR016024
Domain-

VPS8 BSN MDM4 CBLB USP16 MNAT1 MEX3B

6.72e-034499273.30.40.10
DomainZnf_RING/FYVE/PHD

VPS8 BSN MDM4 CBLB USP16 MNAT1 MEX3B

7.54e-03459927IPR013083
DomainCRAL-TRIO_dom

NF1 PLEKHG4

8.35e-0328922IPR001251
Pubmed

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.

TSNAXIP1 NCOR1 ARNT HAUS1 NCAPD2 WT1 TNS2 HOOK2 ANKHD1 MDM4 CBLB MNAT1 SEMA4G

1.17e-10419941327107012
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOR1 LMNA NUMA1 WT1 GLIS3 IGSF9B BSN MDM4 ADNP MEX3B TP73

2.50e-08430941135044719
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NCOR1 ATF6 ARNT UBR5 PLEKHG4 HIPK1 NCAPD2 SIX1 ANKHD1 MDM4 ADNP NOVA1 LRRFIP2 NOVA2

7.70e-08857941425609649
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP2 NF1 UBR5 USP9X OTUD7A FRYL USP16

1.57e-0714794729576527
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

NF1 LMNA RPLP2 UBR5 POLA1 USP9X NUMA1 NCAPD2 FRYL ANKHD1 ADNP DDB1

2.04e-07653941222586326
Pubmed

Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.

ARNT ARNT2 SIM1

3.80e-07694317826745
Pubmed

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.

ARNT ARNT2 SIM1

3.80e-0769438927054
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 ABLIM1 NF1 RPLP2 CCSER2 OTUD7A FRYL PEAK1 PPIP5K2 MDM4 MEX3B DENND4C DOP1B

5.70e-07861941336931259
Pubmed

MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

ARNT ARNT2 SIM1

6.64e-07794327472814
Pubmed

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

ARNT ARNT2 SIM1

6.64e-07794327782878
Pubmed

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.

ARNT ARNT2 SIM1

1.06e-06894311782478
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

NCOR1 LMNA RPLP2 USP9X NUMA1 NCAPD2 MED1 BRAT1 CTTNBP2NL DENND4C

1.12e-06503941016964243
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOR1 ABLIM1 SCML2 USP9X NUMA1 NCAPD2 PEAK1 MED1 ANKHD1 ADNP

2.44e-06549941038280479
Pubmed

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.

ARNT ARNT2 SIM1

3.11e-061194311381139
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

NF1 LMNA RPLP2 UBR5 USP9X NUMA1 CCSER2 MED1 ADNP

3.15e-0644094934244565
Pubmed

Functional proteomics mapping of a human signaling pathway.

NCOR1 ARNT UBR5 LNPEP HIPK1 PPP1R15B CSPG4 VPS8 CBLB DDB1

4.68e-06591941015231748
Pubmed

A census of human transcription factors: function, expression and evolution.

ATF6 ARNT HOXD1 ZBED4 ARNT2 WT1 GATA5 SIX1 ADNP NR1D1 TP73 PGR

6.26e-06908941219274049
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

NF1 LMNA RPLP2 POLA1 USP9X PSMB2 NUMA1 NCAPD2 PEAK1 BSN ANKHD1 ADNP DDB1 LANCL2 LRRFIP2

6.35e-061425941530948266
Pubmed

Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.

ARNT ARNT2

7.23e-06294215466261
Pubmed

The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.

NOVA1 NOVA2

7.23e-0629429789075
Pubmed

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

TET2 WT1

7.23e-06294225482556
Pubmed

Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.

NOVA1 NOVA2

7.23e-06294210368286
Pubmed

WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.

TET2 WT1

7.23e-06294225601757
Pubmed

Replication and extension of association between common genetic variants in SIM1 and human adiposity.

ARNT2 SIM1

7.23e-06294221512513
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

7.23e-06294226807827
Pubmed

SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical Exposure.

SIX1 PGR

7.23e-06294231597742
Pubmed

The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.

NOVA1 NOVA2

7.23e-06294210811881
Pubmed

Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain.

ARNT SIM1

7.23e-06294232932609
Pubmed

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

UBR5 PGR

7.23e-06294237478846
Pubmed

Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.

ARNT ARNT2

7.23e-06294217023418
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

7.23e-06294231150793
Pubmed

Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.

NCOR1 NR1D1

7.23e-06294220581824
Pubmed

Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1).

NCOR1 NR1D1

7.23e-06294224794873
Pubmed

Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas.

WT1 PGR

7.23e-06294223706170
Pubmed

Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.

NOVA1 NOVA2

7.23e-06294220558669
Pubmed

An RNA map predicting Nova-dependent splicing regulation.

NOVA1 NOVA2

7.23e-06294217065982
Pubmed

CLIP identifies Nova-regulated RNA networks in the brain.

NOVA1 NOVA2

7.23e-06294214615540
Pubmed

HITS-CLIP yields genome-wide insights into brain alternative RNA processing.

NOVA1 NOVA2

7.23e-06294218978773
Pubmed

Nova regulates brain-specific splicing to shape the synapse.

NOVA1 NOVA2

7.23e-06294216041372
Pubmed

Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.

NF1 PGR

7.23e-06294219940123
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP2 USP9X USP16

8.50e-06159439827704
Pubmed

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.

NCOR1 LMNA NUMA1

8.50e-061594311092755
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP2 USP9X USP16

1.26e-051794323287719
Pubmed

Defining the membrane proteome of NK cells.

NCOR1 NF1 RPLP2 WDR11 UBR5 LNPEP USP9X IGHMBP2 PSMB2 NCAPD2 MED1 ITGAL BRAT1

1.57e-051168941319946888
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

NF1 LMNA RPLP2 WDR11 UBR5 PLEKHG4 POLA1 PSMB2 NUMA1 NCAPD2 ANKHD1 ADNP USP16 DDB1

1.62e-051353941429467282
Pubmed

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.

ARNT MED1 DDB1

1.80e-051994317392787
Pubmed

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.

NCOR1 MED1

2.16e-05394230575522
Pubmed

Progesterone receptor B recruits a repressor complex to a half-PRE site of the estrogen receptor alpha gene promoter.

NCOR1 PGR

2.16e-05394219147702
Pubmed

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).

ARNT ARNT2

2.16e-0539428657146
Pubmed

cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.

ARNT SIM1

2.16e-0539428561800
Pubmed

Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.

ARNT ARNT2

2.16e-05394218096572
Pubmed

MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53.

MDM4 TP73

2.16e-05394234716260
Pubmed

MdmX is a substrate for the deubiquitinating enzyme USP2a.

USP2 MDM4

2.16e-05394219838211
Pubmed

Expression of Arnt and Arnt2 mRNA in developing murine tissues.

ARNT ARNT2

2.16e-05394212502753
Pubmed

The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.

NCOR1 NR1D1

2.16e-05394215761026
Pubmed

Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.

CSPG4 GABBR1

2.16e-05394235296664
Pubmed

Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.

CSPG4 WT1

2.16e-05394229291617
Pubmed

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.

ARNT ARNT2

2.16e-05394236343253
Pubmed

MDM2 and MDMX bind and stabilize the p53-related protein p73.

MDM4 TP73

2.16e-05394210469568
Pubmed

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

ARNT2 SIM1

2.16e-05394224814368
Pubmed

Aberrant methylation of tumour suppressor genes WT1, GATA5 and PAX5 in hepatocellular carcinoma.

WT1 GATA5

2.16e-05394227171388
Pubmed

Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.

NCOR1 NR1D1

2.16e-0539428948627
Pubmed

Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.

NCOR1 NR1D1

2.16e-0539429482666
Pubmed

An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature.

MED1 NR1D1

2.16e-05394220160030
Pubmed

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.

LMNA RPLP2 WDR11 USP9X LRRFIP2

2.26e-0512494535516420
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NF1 LMNA RPLP2 UBR5 NUMA1 NCAPD2

2.36e-0521094616565220
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ARNT HOXD1 ARNT2 WT1 GLIS3 GATA5 SIM1 MED1 SIX1 DDB1 TP73

2.53e-05877941120211142
Pubmed

Photocaged Cell-Permeable Ubiquitin Probe for Temporal Profiling of Deubiquitinating Enzymes.

USP2 USP9X NUMA1 USP16

2.81e-056494433141564
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

ABLIM1 NF1 UBR5 USP9X CCSER2 FRYL CTTNBP2NL DENND4C

2.92e-0544694824255178
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

ARNT LMNA ZBED4 MYO5B PSMB2 SIX1 ADNP DDB1 TP73

2.95e-0558394929844126
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

NCOR1 ABLIM1 ARNT LMNA MYO5B RPLP2 IGHMBP2 PSMB2 NUMA1 MED1 DDB1 LANCL2 LRRFIP2

3.10e-051247941327684187
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

ABLIM1 UBR5 USP9X HIPK1 NUMA1 PEAK1 CBLB

3.10e-0532794715592455
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

ABLIM1 LMNA RPLP2 PEAK1 BSN GABBR1

4.02e-0523194616452087
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

NCOR1 SCML2 POLA1 NCAPD2 MED1 ADNP DDB1

4.04e-0534194732971831
Pubmed

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

NOVA1 NOVA2

4.32e-05494226446569
Pubmed

Gene mapping of mouse IL-4 receptor: the loci of interleukin 4 (IL-4) receptor gene and lymphocyte function associated antigen 1 (LFA-1) gene are closely linked on chromosome 7.

ITGAL IL4R

4.32e-0549421680807
Pubmed

Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.

USP2 MDM4

4.32e-05494224445145
Pubmed

Aryl Sulfonamides Induce Degradation of Aryl Hydrocarbon Receptor Nuclear Translocator through CRL4DCAF15 E3 Ligase.

ARNT DDB1

4.32e-05494233168788
Pubmed

Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells.

MDM4 TP73

4.32e-05494230603043
Pubmed

Associations between oxytocin-related genes and autistic-like traits.

ARNT2 SIM1

4.32e-05494224635660
Pubmed

WT1, MSH6, GATA5 and PAX5 as epigenetic oral squamous cell carcinoma biomarkers - a short report.

WT1 GATA5

4.32e-05494227491556
Pubmed

β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation.

ITGAL CBLB

4.32e-05494223310953
Pubmed

Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression.

NF1 LMNA

4.32e-05494226490262
Pubmed

NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.

NF1 CSPG4

4.32e-05494223318450
Pubmed

Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.

WT1 TP73

4.32e-05494210744705
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCOR1 ABLIM1 SCML2 NF1 LMNA NUMA1 MED1 NR1D1 USP16 CTTNBP2NL

4.73e-05774941015302935
Pubmed

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.

LNPEP NR1D1 IL4R NOVA1 NOVA2

4.95e-0514694529688375
Pubmed

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

GABBR1 NOVA1 NOVA2

5.34e-052794323359859
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

NCOR1 LMNA UBR5 NUMA1 ANKHD1 ADNP LANCL2

5.39e-0535794737059091
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOR1 ABLIM1 NF1 UBR5 USP9X NUMA1 BSN ADNP UNC79 DDB1 LRRFIP2

5.90e-05963941128671696
Pubmed

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.

UBR5 USP9X CBLB DDB1

6.44e-057994427325702
Pubmed

The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.

ARNT NF1 WT1 MDM4

6.76e-058094428205554
Pubmed

Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.

NOVA1 NOVA2

7.19e-05594219221030
Pubmed

Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.

UBR5 DDB1

7.19e-05594227721409
Pubmed

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.

MDM4 TP73

7.19e-05594221088494
Pubmed

Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.

WT1 SIX1

7.19e-05594235178390
Pubmed

CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

TET2 DDB1

7.19e-05594225557551
Pubmed

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

ARNT ARNT2

7.19e-0559429545558
Pubmed

Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein.

ARNT SIM1

7.19e-0559429020169
Pubmed

HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.

UBR5 DDB1

7.19e-05594223612978
InteractionSIM1 interactions

ARNT ARNT2 SIM1

5.24e-068933int:SIM1
InteractionHAPSTR1 interactions

ABLIM1 ARNT NF1 WDR11 UBR5 USP9X NCAPD2 BSN ANKHD1 MDM4 ADNP CBLB DDB1 LANCL2 DOP1B

5.63e-068299315int:HAPSTR1
InteractionSIRT6 interactions

NF1 LMNA RPLP2 UBR5 USP9X NUMA1 NCAPD2 CCSER2 MED1 ADNP PCDHGC3 DDB1 MNAT1

6.08e-066289313int:SIRT6
InteractionPML interactions

TET2 NCOR1 USP2 ABLIM1 ARNT NF1 LMNA UBR5 HIPK1 NUMA1 MED1 CDH19 BRAT1 CTTNBP2NL TP73

2.28e-059339315int:PML
InteractionZCCHC14 interactions

TET2 PLEKHG4 TNS2 MEX3B

2.50e-0537934int:ZCCHC14
InteractionWWTR1 interactions

NCOR1 ABLIM1 ARNT SCML2 ARNT2 NUMA1 NCAPD2 PEAK1 ANKHD1 ADNP

2.50e-054229310int:WWTR1
InteractionRNF6 interactions

ABLIM1 USP9X TNS2 HOOK2 LRRFIP2

2.68e-0576935int:RNF6
InteractionYAP1 interactions

NCOR1 ABLIM1 ARNT SCML2 NF1 LMNA USP9X ARNT2 NUMA1 WT1 GLIS3 IGSF9B MED1 ADNP NR1D1 TP73

3.78e-0510959316int:YAP1
InteractionMATR3 interactions

NCOR1 ARNT LMNA UBR5 PLEKHG4 RBM4B USP9X NUMA1 NCAPD2 DDB1 NOVA1 NOVA2

4.72e-056559312int:MATR3
InteractionTFAP2D interactions

NCOR1 ARNT PLEKHG4 ARNT2 TNS2

5.74e-0589935int:TFAP2D
InteractionERG interactions

TET2 NCOR1 UBR5 USP9X HIPK1 NUMA1 MNAT1

7.82e-05223937int:ERG
InteractionBTNL2 interactions

CNTNAP3B ATF6 KREMEN2 CSPG4 CNTNAP3 SEMA4G

8.25e-05155936int:BTNL2
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B ABLIM1 CNTNAP3 CTTNBP2NL IL4R NOVA2 JAM2

2.20e-071999473a4deea6e11a0555d27497b7c9983350797aac69
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B ABLIM1 CNTNAP3 IL4R NOVA2 JAM2

2.86e-06187946e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellRA-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

GREB1L TSNAXIP1 CNTNAP3B RBM4B UNC79

4.58e-061159450a37816898eaa18ae49d4d936e1a760f089e0ceb
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

RBM48 SIX1 CDH19 GABBR1 NOVA1

1.41e-05145945e808502fa52baf1c400f3c9b918a167127e78af9
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LNPEP KREMEN2 ITGAL BRAT1 PGR

2.27e-05160945b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LNPEP KREMEN2 ITGAL BRAT1 PGR

2.27e-051609459caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LNPEP KREMEN2 ITGAL BRAT1 PGR

2.27e-05160945229841be7b984a00a301cd5d88c11226a90d8a88
ToppCellE16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LNPEP KREMEN2 ITGAL BRAT1 PGR

2.27e-0516094599c9ae2041445539fada842e1af01368669bfca0
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRYL IGSF9B BSN USP16 DENND4C

3.39e-05174945f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellNS-moderate-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CSPG4 OTUD7A CDH19 PCDHGC3 HHATL

3.49e-05175945f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B ABLIM1 FRYL CTTNBP2NL JAM2

3.89e-051799452a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

CNTNAP3B ABLIM1 IL4R NOVA2 JAM2

4.32e-0518394546be9f96755c7b65aeac061d95d15abeb6466034
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B MYO5B CNTNAP3 GLIS3 PGR

4.43e-051849457d41784eac0935e77d6bc701f20c693adf998730
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

ZBED4 WDR11 POLA1 IGHMBP2 SERINC5

4.54e-051859451979d189c204f4c2893e3170a514ee7d5523406c
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B ABLIM1 CNTNAP3 CTTNBP2NL JAM2

4.54e-05185945a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

CNTNAP3B ABLIM1 IL4R NOVA2 JAM2

4.78e-051879452d20193a6cacdfa4877457c97b0077408942186c
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

NF1 LNPEP USP9X HIPK1 CBLB

4.91e-05188945ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

CNTNAP3B ABLIM1 ARNT2 CTTNBP2NL JAM2

4.91e-05188945eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B AFF3 FRYL NOVA2 JAM2

4.91e-05188945117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GREB1L CNTNAP3B CNTNAP3 BSN UNC79

4.91e-05188945c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 CTTNBP2NL NOVA2 JAM2

5.03e-05189945fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

LNPEP PPP1R15B FRYL CBLB DOP1B

5.29e-051919459454f642c3621370fa23640b631301346b300950
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

ABLIM1 HIPK1 PPP1R15B SERINC5 CBLB

5.42e-0519294547646d7e4990be85072987f92bf18d52f8da752e
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMNA TNS2 PCDHGC3 NOVA2 JAM2

5.42e-05192945be75783d9578974b662e1cb13bd3442a921fd50a
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMNA TNS2 PCDHGC3 NOVA2 JAM2

5.42e-051929454fc98f30f8e738816cd93101fbe8ac40889e302a
ToppCellLA-14._Fibroblast_III|LA / Chamber and Cluster_Paper

WT1 GLIS3 CDH19 CBLB NOVA1

5.56e-051939457426c291bac59e539c427bcaae18abc7d397d44e
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABLIM1 LMNA CCSER2 SERINC5 CBLB

5.56e-05193945c3cffafc1d40c3d7cf81034d5c51f1c78f5eb0a9
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLA1 NCAPD2 FLVCR2 NR1D1 CTTNBP2NL

5.69e-05194945effd38e51062b225ecabc7e1c50154e65495d559
ToppCellLA-14._Fibroblast_III|World / Chamber and Cluster_Paper

WT1 GLIS3 CDH19 CBLB NOVA1

5.69e-05194945803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ABLIM1 AFF3 GLIS3 SERINC5 LRRFIP2

5.83e-05195945c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B CTTNBP2NL IL4R NOVA2 JAM2

5.83e-05195945fde8e7b38b3631109b95ef111c5f6e3f9878cfbd
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABLIM1 HIPK1 AFF3 CCSER2 CBLB

5.83e-05195945ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 MYO5B ARNT2 GLIS3 SIM1

5.98e-051969456ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

CNTNAP3B AFF3 IL4R NOVA2 JAM2

6.12e-051979457e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 CDH19 CBLB NOVA1 JAM2

6.12e-05197945ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-CD8+_T_naive|Bac-SEP / Disease, condition lineage and cell class

RPLP2 CCSER2 GLIS3 SERINC5 TRAV21

6.27e-05198945a9a009e5eeb935232034635ad4a3c27d83c081ac
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABLIM1 MYO5B AFF3 TMC5 DOP1B

6.58e-05200945c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABLIM1 MYO5B HOOK2 TMC5 DOP1B

6.58e-05200945d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellCOVID-19-kidney-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B SCML2 CNTNAP3 MS4A12

2.72e-04148944f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

WT1 IGSF9B BSN UNC79

2.80e-04149944649eb3441fa859591ea85f1ed5fcf08af272a32b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D175|Adult / Lineage, Cell type, age group and donor

AFF3 ARNT2 GLIS3 TMC5

2.87e-04150944b0b6ba3686d3eb8a9b249d30be14111de3b893be
ToppCellURO-Lymphocyte-T_NK-CD4_Naive|URO / Disease, Lineage and Cell Type

CNTNAP3B PLEKHG4 SERINC5 TMC5

3.17e-041549446c214ad5cbbfa8bab3f76b593cb598dfb914b566
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMNA PEAK1 CBLB PGR

3.25e-0415594482e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNS2 IGSF9B CDH19 GABBR1

3.25e-0415594477fdae85d36efb776db977eb424b32487ef222e4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMNA PEAK1 CBLB PGR

3.25e-04155944979c1d53b435a82c57d16707eed8ba7346326866
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2|TCGA-Lung / Sample_Type by Project: Shred V9

SCML2 ACRV1 BSN NOVA1

3.49e-041589449dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN5 GATA5 IL4R NOVA2

3.58e-04159944d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

USP2 CSPG4 MEX3B PGR

3.58e-041599447cda111bb98f1241989e49d490bdf51a712ea589
ToppCellHippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Hippocampus / BrainAtlas - Mouse McCarroll V32

UBR5 CNTNAP3 PPIP5K2 SEMA4G

3.75e-04161944b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Cajal-Retzius|3_mon / Sample Type, Dataset, Time_group, and Cell type.

LNPEP TP73 PGR HHATL

3.84e-041629441f589a763f3fd4e1e612809ef3903879d47dc1d8
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

LNPEP SERINC5 MDM4 NT5C1B

3.84e-04162944b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTUD7A IGSF9B PCDHGC3 SEMA4G

4.11e-041659441703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellLPS-antiTNF-Epithelial_airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HOXD1 HIPK1 SIX1 TMC5

4.21e-04166944eb942ed68677e55c46cb039046f45686d4062d7c
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HOXD1 HIPK1 SIX1 TMC5

4.21e-041669441df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HOXD1 HIPK1 SIX1 TMC5

4.21e-041669449628522e7af8f8edca733588a364ab2454ac5ca5
ToppCellLPS-antiTNF-Endothelial-Mes-Like-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OTUD7A TNS2 CDH19 JAM2

4.21e-0416694494a00edf66d54bc5f7343daea700ca26cf38fd90
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

ADNP UNC79 SEMA4G PGR

4.31e-041679449efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LANCL2 DENND4C NOVA2 JAM2

4.31e-04167944774f3264318b002d0df5d06d41d645366038d0bf
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

ADNP UNC79 SEMA4G PGR

4.31e-04167944904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellControl|World / group, cell type (main and fine annotations)

LMNA MYO5B AFF3 TMC5

4.40e-04168944a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_naive|lymph-node_spleen / Manually curated celltypes from each tissue

KREMEN2 AFF3 PEAK1 PGR

4.40e-04168944494d5a11154ff22fedb25f4036d730cef376da60
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TSNAXIP1 ACRV1 TP73 NOVA1

4.50e-041699448bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Club_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HOXD1 HIPK1 SIX1 TMC5

4.50e-041699448c96e1baa38ec5e777e627ab9dbce025e771f2c0
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

SCML2 BSN UNC79 MEX3B

4.50e-041699449c4e83fe8225d16173a103bf5a57b17d623be923
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Club_cells-Airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HOXD1 HIPK1 SIX1 TMC5

4.50e-0416994486041be5d3aeab5b9269f7912791b944f325a1b4
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPLP2 TMC5 UNC79 TP73

4.50e-0416994412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABLIM1 CCSER2 NOVA1 JAM2

4.60e-0417094455fe16d98ea284d05fb899888e4569c685644c7b
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IGHMBP2 AFF3 MDM4 DENND4C

4.60e-04170944070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CSPG4 CDH19 GABBR1 PGR

4.60e-041709445570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellCOVID-19_Convalescent-cDC|COVID-19_Convalescent / Disease condition and Cell class

LMNA AFF3 BRAT1 MEX3B

4.71e-041719449ccaa9f1629818b0f63a5d930ee78c01e04cd98d
ToppCellCOVID-19_Convalescent-cDC-|COVID-19_Convalescent / Disease condition and Cell class

LMNA AFF3 BRAT1 MEX3B

4.71e-04171944fb5fae8b3adafcbb7c5618d887966b418355ed4d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN5 CSPG4 WT1 TMC5

4.81e-0417294408a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTN5 CSPG4 WT1 TMC5

4.81e-04172944553701349444eb366df3c11f54bb093434f153c6
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CNTNAP3B CTTNBP2NL NOVA2 JAM2

4.81e-04172944de9b11ab109d04937186c09772cec9105a935f95
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO5B VPS8 HOOK2 FLVCR2

4.92e-041739449dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B GATA5 IL4R NOVA2

4.92e-04173944afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFF3 MDM4 CBLB DOP1B

4.92e-04173944694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GREB1L GLIS3 BSN NOVA1

5.03e-04174944a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 PEAK1 DENND4C PGR

5.13e-041759441b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMNA GLIS3 PEAK1 CBLB

5.13e-04175944910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CSPG4 WT1 PCDHGC3 PGR

5.13e-0417594412f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

CNTNAP3B ARNT2 NOVA2 JAM2

5.13e-041759440a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMNA GLIS3 PEAK1 CBLB

5.13e-04175944f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCellwk_08-11-Epithelial-Proximal_epithelial-SMG_basal_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KREMEN2 CSPG4 SIX1 UNC79

5.13e-041759444462000b22af227555413ba202a872868eecde6c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B MYO5B CNTNAP3 HHATL

5.25e-04176944682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

ABLIM1 NUMA1 CCSER2 GABBR1

5.36e-04177944e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellnormal-na-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ABLIM1 RPLP2 CCSER2 SERINC5

5.47e-04178944fa3585383a1e7da460c88a802aaa81246d681b6b
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CNTNAP3B CNTNAP3 NOVA2 JAM2

5.47e-04178944c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-CLDN10+_cells|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GLIS3 ILDR1 SERINC5 SIM1

5.59e-041799447eca1e19ae6b5b1f18c721691dc3e860705628f2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B MYO5B CNTNAP3 HHATL

5.59e-04179944d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B CTTNBP2NL NOVA2 JAM2

5.59e-041799441ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellLA-01._Fibroblast_I|LA / Chamber and Cluster_Paper

GLIS3 CDH19 CBLB NOVA1

5.59e-04179944dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

WDR11 PPP1R15B ADNP TP73

5.71e-04180944974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

C12orf56 GLIS3 SIX1 TMC5

5.71e-04180944b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

WDR11 PPP1R15B ADNP TP73

5.71e-04180944703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B ABLIM1 CNTNAP3 JAM2

5.71e-0418094427e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B MYO5B CNTNAP3 PGR

5.83e-04181944af92b8b7f455210dab502ef6964f3a0162180759
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

ABLIM1 AFF3 NOVA2 JAM2

5.83e-0418194426eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|(2)_5-FU / Stress and Cell class

LMNA AFF3 NR1D1 JAM2

5.83e-0418194456ae86072858c156681507aecd1bc6cb0a3372d2
ToppCellTCGA-Colorectal-Solid_Tissue_Normal|TCGA-Colorectal / Sample_Type by Project: Shred V9

USP2 AFF3 MS4A12 CDH19

5.83e-0418194488f6f56f5f58b479d5db91b32c45934c045f88ea
DrugMesoridazine besylate [32672-69-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A

ABLIM1 ARNT ZBED4 LNPEP NUMA1 CCSER2 FLVCR2 DOP1B

1.42e-061969387017_DN
DrugHexetidine [141-94-6]; Down 200; 11.8uM; HL60; HT_HG-U133A

ATF6 NF1 HOXD1 HIPK1 NUMA1 TNS2 MDM4 NR1D1

1.48e-061979382457_DN
Drug11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol

ARNT ARNT2 PGR

5.44e-069933ctd:C541120
DrugEtanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT_HG-U133A

NF1 HOXD1 LMNA KREMEN2 NUMA1 ADGRL1 SIX1

1.49e-051949376072_DN
DrugCefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; MCF7; HT_HG-U133A

SCML2 NF1 KREMEN2 NUMA1 ADGRL1 MDM4 SEMA4G

1.60e-051969374148_DN
DrugIsopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; HL60; HT_HG-U133A

NF1 HOXD1 LMNA AFF3 TNS2 ADGRL1 DOP1B

1.60e-051969372534_DN
DrugTocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A

NF1 LMNA WDR11 NUMA1 ADGRL1 RBM48 NR1D1

1.60e-051969373256_UP
DrugTetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A

ABLIM1 ARNT SCML2 PSMB2 TNS2 ADGRL1 SEMA4G

1.60e-051969372888_DN
DrugRolitetracycline [751-97-3]; Up 200; 7.6uM; MCF7; HT_HG-U133A

GREB1L LMNA KREMEN2 CNTN5 ADGRL1 IGSF9B PEAK1

1.60e-051969373369_UP
Drugestradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A

TSNAXIP1 USP2 ACRV1 NUMA1 MED1 NR1D1 NOVA2

1.60e-051969376928_UP
DrugEvoxine [522-11-2]; Up 200; 11.6uM; PC3; HT_HG-U133A

NF1 HOXD1 ACRV1 ARNT2 NUMA1 PEAK1 JAM2

1.65e-051979373681_UP
DrugSulfadimethoxine [122-11-2]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ARNT SCML2 NF1 KREMEN2 TNS2 TMC5 IL4R

1.70e-051989373441_DN
DrugOzagrel hydrochloride [78712-43-3]; Down 200; 15.2uM; MCF7; HT_HG-U133A

NF1 KREMEN2 PSMB2 NUMA1 CCSER2 ADGRL1 DOP1B

1.70e-051989375983_DN
Drugestradiol, USP; Up 200; 0.01uM; PC3; HG-U133A

GREB1L TSNAXIP1 ATF6 MED1 IL4R SEMA4G DENND4C

1.70e-05198937665_UP
DrugAcemetacin [53164-05-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

NCOR1 ATF6 IGHMBP2 KREMEN2 TNS2 ADGRL1 RBM48

1.70e-051989377442_DN
DrugAceclofenac [89796-99-6]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ABLIM1 NF1 HOXD1 ZBED4 IGHMBP2 ADGRL1 TMC5

1.70e-051989372281_DN
DrughmimBF4

NOVA1 NOVA2

4.94e-053932CID002734179
Drug1-octyl-3-methylimidazolium tetrafluoroborate

NOVA1 NOVA2

4.94e-053932CID011460221
Drugbis(hexamethylene)triamine

ARNT POLA1 ARNT2 DDB1

8.14e-0556934CID000008924
DrugAdiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ATF6 ABLIM1 ZBED4 HIPK1 FLVCR2 SIX1

1.06e-041839361709_DN
DrugKetanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A

ARNT SCML2 NF1 HIPK1 NUMA1 MED1

1.27e-041899366649_DN
DrugFenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

ATF6 ABLIM1 NF1 HIPK1 NUMA1 MED1

1.34e-041919364279_DN
DrugScopolamine Hydrobromide

LNPEP NR1D1 GABBR1 NOVA1 NOVA2

1.34e-04120935ctd:D012601
Drugestradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A

USP2 NF1 ZBED4 ACRV1 PSMB2 PGR

1.38e-041929365238_UP
DrugCP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A

ABLIM1 HIPK1 NUMA1 TNS2 MED1 TMC5

1.42e-041939363906_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; HL60; HT_HG-U133A

NF1 LNPEP NUMA1 TNS2 TMC5 MDM4

1.42e-041939362459_DN
DrugGSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A

GREB1L USP2 ADGRL1 NR1D1 IL4R NOVA2

1.46e-041949366589_UP
DrugAjmalicine hydrochloride [4373-34-6]; Down 200; 10.2uM; HL60; HG-U133A

ARNT NF1 PSMB2 HOOK2 MNAT1 LRRFIP2

1.46e-041949361748_DN
DrugNorethynodrel [68-23-5]; Up 200; 13.4uM; HL60; HT_HG-U133A

ARNT IGHMBP2 ACRV1 VPS8 CCSER2 LRRFIP2

1.46e-041949361860_UP
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A

GREB1L NF1 HOXD1 LMNA ADGRL1 SEMA4G

1.46e-041949363807_DN
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

SLC36A1 VPS8 NUMA1 CCSER2 FLVCR2 CBLB

1.50e-041959367444_DN
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; HL60; HT_HG-U133A

ARNT LMNA VPS8 NUMA1 CCSER2 WT1

1.50e-041959362918_DN
DrugCefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; PC3; HT_HG-U133A

GREB1L ARNT NF1 IGHMBP2 WT1 ADGRL1

1.50e-041959367394_UP
Drughaloperidol; Down 200; 10uM; HL60; HT_HG-U133A

ARNT LMNA AFF3 NUMA1 IL4R SEMA4G

1.50e-041959366163_DN
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

NF1 LMNA CCSER2 FRYL RBM48 LRRFIP2

1.50e-041959366971_DN
DrugMoroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; MCF7; HT_HG-U133A

NCOR1 ATF6 LMNA PSMB2 TMC5 DOP1B

1.50e-041959361527_DN
DrugProgesterone [57-83-0]; Down 200; 12.8uM; MCF7; HT_HG-U133A

NCOR1 ATF6 NF1 LMNA ADGRL1 SIX1

1.50e-041959363287_DN
DrugOxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ATF6 ARNT NF1 LMNA TNS2 TMC5

1.50e-041959366770_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A

ARNT NF1 LMNA IGHMBP2 ADGRL1 NR1D1

1.54e-041969365569_DN
DrugTimolol maleate salt [26921-17-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A

ARNT HOXD1 LMNA IL4R SEMA4G PGR

1.54e-041969365280_DN
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A

NF1 ZBED4 NUMA1 TNS2 MDM4 PGR

1.54e-041969364749_DN
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

ARNT NF1 LMNA IGHMBP2 ACRV1 IL4R

1.54e-041969366898_DN
DrugChrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT_HG-U133A

NCOR1 SCML2 UBR5 PSMB2 WT1 NOVA1

1.54e-041969367139_DN
DrugNaltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A

NCOR1 NF1 ZBED4 NUMA1 FLVCR2 SEMA4G

1.54e-041969365765_DN
DrugCatechin-(+,-) hydrate [7295-85-4]; Down 200; 13.8uM; MCF7; HT_HG-U133A

NCOR1 ATF6 NF1 LNPEP KREMEN2 NUMA1

1.54e-041969363351_DN
DrugMethoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; MCF7; HT_HG-U133A

ABLIM1 KREMEN2 PSMB2 NUMA1 ADGRL1 IL4R

1.54e-041969363302_DN
DrugPyrithyldione [77-04-3]; Down 200; 24uM; MCF7; HT_HG-U133A

TSNAXIP1 ATF6 ARNT TMC5 NR1D1 IL4R

1.54e-041969363482_DN
Drug(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; PC3; HT_HG-U133A

SCML2 HOXD1 CNTN5 ADGRL1 RBM48 DOP1B

1.54e-041969365833_UP
DrugR(+)-verapamil hydrochloride; Up 200; 10uM; MCF7; HG-U133A

LMNA IGHMBP2 ACRV1 PSMB2 CCSER2 TNS2

1.54e-04196936164_UP
DrugNalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ARNT KREMEN2 NUMA1 TNS2 ADGRL1 SIX1

1.54e-041969362225_DN
Drugphenformin hydrochloride; Up 200; 10uM; MCF7; HG-U133A

GREB1L ATF6 ABLIM1 ARNT CCSER2 NOVA1

1.59e-0419793621_UP
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A

NCOR1 ATF6 ARNT LMNA FLVCR2 RBM48

1.59e-041979367011_DN
DrugTrichlorfon [52-68-6]; Up 200; 15.6uM; MCF7; HT_HG-U133A

ARNT NF1 NUMA1 PEAK1 SIX1 PGR

1.59e-041979361675_UP
Drug11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

NCOR1 ZBED4 IGHMBP2 KREMEN2 ACRV1 AFF3

1.59e-041979367514_UP
DrugWY-14643; Down 200; 100uM; MCF7; HG-U133A

GREB1L ATF6 ARNT KREMEN2 CCSER2 DENND4C

1.59e-04197936487_DN
DrugClozapine [5786-21-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

USP2 ACRV1 NUMA1 CDH19 SEMA4G NOVA2

1.59e-041979365630_UP
DrugZoxazolamine [61-80-3]; Down 200; 23.8uM; MCF7; HT_HG-U133A

ARNT LMNA NUMA1 SIX1 NR1D1 IL4R

1.63e-041989365390_DN
DrugCeftazidime pentahydrate [78439-06-2]; Down 200; 6.2uM; HL60; HG-U133A

NCOR1 ARNT HOXD1 LMNA HIPK1 IL4R

1.63e-041989361721_DN
DrugAmoxapine [14028-44-5]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ARNT LMNA CCSER2 ADGRL1 TMC5 IL4R

1.63e-041989361513_DN
DrugGuaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A

ARNT NF1 HOXD1 IGHMBP2 NUMA1 IL4R

1.63e-041989363897_DN
DrugEpitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A

ARNT ZBED4 TNS2 ADGRL1 IL4R DENND4C

1.63e-041989364788_DN
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

GREB1L NF1 IGHMBP2 CNTN5 SIX1 NOVA1

1.63e-041989365972_DN
DrugIsoxicam [34552-84-6]; Down 200; 12uM; MCF7; HT_HG-U133A

ARNT LMNA ZBED4 NUMA1 CCSER2 DOP1B

1.63e-041989367028_DN
DrugCefotiam hydrochloride; Down 200; 7.2uM; HL60; HT_HG-U133A

ATF6 ARNT NF1 TMC5 MDM4 SEMA4G

1.63e-041989362458_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; PC3; HT_HG-U133A

USP2 CNTN5 ACRV1 CSPG4 FLVCR2 NOVA2

1.63e-041989364681_UP
DrugNitrocaramiphen hydrochloride; Down 200; 10.8uM; MCF7; HT_HG-U133A

NCOR1 ATF6 SLC36A1 CCSER2 NR1D1 IL4R

1.63e-041989367464_DN
DrugNifenazone [2139-47-1]; Up 200; 13uM; MCF7; HT_HG-U133A

USP2 NF1 LMNA CSPG4 PSMB2 PGR

1.63e-041989362285_UP
DrugFenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A

NF1 LMNA LNPEP KREMEN2 CCSER2 NR1D1

1.63e-041989366001_DN
DrugDantrolene sodium salt [14663-23-1]; Up 200; 11.8uM; HL60; HT_HG-U133A

LMNA LNPEP ACRV1 TNS2 IL4R SEMA4G

1.63e-041989362369_UP
DrugPropidium iodide [25535-16-4]; Down 200; 6uM; HL60; HT_HG-U133A

NF1 HOXD1 AFF3 NUMA1 TNS2 NR1D1

1.63e-041989362541_DN
Drugbeta-hydroxyisovaleric acid

USP2 USP16

1.64e-045932ctd:C004961
DrugemimBF4

NOVA1 NOVA2

1.64e-045932CID002769348
Drug1,1-dimethylbiguanide hydrochloride; Down 200; 1000uM; MCF7; HG-U133A

ATF6 ARNT NF1 KREMEN2 ARNT2 TNS2

1.68e-041999364_DN
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A

USP2 ATF6 ARNT NF1 PSMB2 MDM4

1.68e-041999363205_DN
DrugLeucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A

TSNAXIP1 NF1 ACRV1 CSPG4 NOVA2 DOP1B

1.68e-041999363546_UP
Drugtamoxifen citrate; Up 200; 1uM; MCF7; HG-U133A

LNPEP KREMEN2 ACRV1 VPS8 CBLB LRRFIP2

1.68e-04199936143_UP
DrugPhenindione [83-12-5]; Down 200; 18uM; HL60; HG-U133A

ARNT HOXD1 LMNA MED1 NR1D1 LRRFIP2

1.68e-041999361718_DN
DrugNeomycin sulfate [1405-10-3]; Down 200; 4.2uM; HL60; HG-U133A

SLC36A1 HOXD1 ACRV1 LANCL2 IL4R SEMA4G

1.68e-041999361383_DN
DrugCefuroxime sodium salt [56238-63-2]; Down 200; 9uM; MCF7; HT_HG-U133A

ABLIM1 HOXD1 IGHMBP2 KREMEN2 ADGRL1 NR1D1

1.68e-041999366088_DN
DrugIsoetharine mesylate salt [7279-75-6]; Up 200; 12uM; MCF7; HT_HG-U133A

NF1 HOXD1 RBM48 IL4R TP73 NOVA2

1.72e-042009367170_UP
DrugDiphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; HL60; HG-U133A

NF1 HOXD1 LMNA MED1 NR1D1 SEMA4G

1.72e-042009361994_DN
DrugPeCDD

ARNT ARNT2 MED1

1.80e-0427933CID000038439
DrugMCDF

ARNT ARNT2 PGR

2.01e-0428933CID000114900
Drug5EtdUTP

POLA1 ACRV1

2.45e-046932CID000188305
Diseasenephroblastoma (is_implicated_in)

WT1 SIX1 TP73

1.04e-0514923DOID:2154 (is_implicated_in)
DiseaseAcute Promyelocytic Leukemia

TET2 NUMA1 WT1 ITGAL

1.31e-0546924C0023487
DiseaseSchwannomatosis, Plexiform

NF1 WT1

9.56e-055922C0751374
DiseaseGlioblastoma

NCOR1 NF1 WT1 MDM4

1.11e-0479924C0017636
DiseaseGiant Cell Glioblastoma

NCOR1 NF1 WT1 MDM4

1.41e-0484924C0334588
DiseaseNeurilemmoma

NF1 WT1

1.43e-046922C0027809
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

2.66e-048922DOID:0060308 (implicated_via_orthology)
Diseasedisorder of pharynx

TET2 ARNT ITGAL

4.04e-0446923MONDO_0020592
DiseaseGlioblastoma Multiforme

NCOR1 NF1 WT1 MDM4

4.11e-04111924C1621958
Diseaseprostate carcinoma

TET2 ABLIM1 LMNA WDR11 GATA5 BSN SIX1 MDM4 ADNP MNAT1

4.62e-048919210EFO_0001663
Diseaseinsomnia measurement

TET2 UBR5 RBM4B CNTN5 VPS8 GLIS3 PPIP5K2

4.80e-04443927EFO_0007876
Diseasecomplement C1q tumor necrosis factor-related protein 5 measurement

USP2 LNPEP

5.19e-0411922EFO_0801494
Diseasecorneal resistance factor

TET2 AFF3 ARNT2 GLIS3 SERINC5 BRAT1 NR1D1

5.33e-04451927EFO_0010067
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

LMNA HOOK2

6.22e-0412922DOID:11726 (implicated_via_orthology)
Diseaseforced expiratory volume

TET2 NCOR1 WDR11 IGHMBP2 AFF3 GLIS3 GATA5 MED1 MDM4

8.02e-04789929EFO_0004314
Diseaseserum non-albumin protein measurement

GREB1L ATF6 ARNT AFF3 NUMA1 IL4R

9.48e-04361926EFO_0004568
Diseaseosteoarthritis, hip, osteoarthritis, knee

NF1 GLIS3 USP16

9.71e-0462923EFO_0004616, EFO_1000786
Diseaseperiprosthetic osteolysis, disease progression measurement

OTUD7A GLIS3

9.83e-0415922EFO_0008336, EFO_0009761
DiseaseMammary Carcinoma, Human

NCOR1 RPLP2 WT1 SIM1 MDM4 TP73 PGR

1.29e-03525927C4704874
DiseaseMammary Neoplasms, Human

NCOR1 RPLP2 WT1 SIM1 MDM4 TP73 PGR

1.29e-03525927C1257931
DiseaseMammary Neoplasms

NCOR1 RPLP2 WT1 SIM1 MDM4 TP73 PGR

1.32e-03527927C1458155
Diseaserenal cell carcinoma (is_implicated_in)

ARNT IL4R TP73

1.32e-0369923DOID:4450 (is_implicated_in)
DiseaseCarcinoma of bladder

PEAK1 MDM4

1.42e-0318922C0699885
DiseaseBreast Carcinoma

NCOR1 RPLP2 WT1 SIM1 MDM4 TP73 PGR

1.49e-03538927C0678222
DiseaseEndometrioma

NCOR1 ARNT MED1 PGR

1.64e-03161924C0269102
DiseaseEndometriosis

NCOR1 ARNT MED1 PGR

1.64e-03161924C0014175
Diseaseneuroimaging measurement

NCOR1 ABLIM1 NF1 AFF3 GLIS3 FRYL TMC5 MNAT1 DENND4C GABBR1

1.83e-0310699210EFO_0004346
DiseaseSarcoma

NF1 MDM4

1.94e-0321922C1261473
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

NCOR1 PGR

1.94e-0321922DOID:11612 (biomarker_via_orthology)
Diseaseotitis media (implicated_via_orthology)

LMNA TP73

2.13e-0322922DOID:10754 (implicated_via_orthology)
DiseaseLeukemia, Myelocytic, Acute

TET2 NF1 WT1 CBLB

2.14e-03173924C0023467
Diseasethyroxine measurement

NCOR1 GLIS3 SIM1

2.25e-0383923EFO_0005130
Diseaseserum iron measurement

CNTN5 TMC5 CDH19

2.49e-0386923EFO_0006332
Diseasesmoking status measurement, chronic obstructive pulmonary disease

TET2 GLIS3 GABBR1

2.66e-0388923EFO_0000341, EFO_0006527
Diseasebreast cancer (is_marker_for)

TET2 LNPEP WT1 SIX1

2.72e-03185924DOID:1612 (is_marker_for)
DiseaseKallmann Syndrome

WDR11 ARNT2

2.98e-0326922C0162809

Protein segments in the cluster

PeptideGeneStartEntry
GIYPASTQLDRNSLS

NT5C1B

251

Q96P26
YTSEDLTSSSRPNGN

AFF3

891

P51826
SQAPARYSLQSANAS

ADNP

386

Q9H2P0
AAAYPSLTNRGSNFA

ARNT

691

P27540
SSPFGTDYRNLANTA

CTTNBP2NL

526

Q9P2B4
ASYSSLREARGSPNT

BRAT1

731

Q6PJG6
SSRSYLALPGNSGED

CNTNAP3

376

Q9BZ76
QASEPYLRVANGSSL

CSPG4

1121

Q6UVK1
RASSSAGTDPQLLLY

CSPG4

1606

Q6UVK1
SSLLASRYDSPINSA

ABLIM1

631

O14639
RDSLYASGANLRDSP

ADGRL1

1381

O94910
PLSLYGENSNSLSSA

ATF6

131

P18850
YLLGSARGTSSQPNE

ACRV1

11

P26436
TSSPSGNAYSSLANR

ARNT2

621

Q9HBZ2
ISSYNLQARSPFSLG

CNTN5

701

O94779
KAALNTSAGNSNPYL

RBM48

181

Q5RL73
SSSGDPAEYNLRSRT

LMNA

571

P02545
NRLPDSALAGLAYSN

HHATL

281

Q9HCP6
RAASPQDLAGGYTSS

MNAT1

276

P51948
LRSNYTPRSNGSTDL

MDM4

206

O15151
AEYGAASPSSAIRTN

HOXD1

221

Q9GZZ0
SPYSTDTLSALRGNS

HIPK1

951

Q86Z02
SYGSSSPALSNRQRF

GABBR1

266

Q9UBS5
SLSPETYGNFDSQSR

HOOK2

161

Q96ED9
SAYNAPSFRAGAQLL

DOP1B

1941

Q9Y3R5
FRSGNYPSSLSNETD

LANCL2

301

Q9NS86
QDASRSPQSLSDTGY

BSN

671

Q9UPA5
HGSSLNRTPSDYDLL

CBLB

791

Q13191
NPCSATYSNLGQSRA

PEAK1

1101

Q9H792
LGYNSNARSNSLRLS

FRYL

1931

O94915
ASYQAALSLGQDPSN

ILDR1

76

Q86SU0
SGLRNSATGYRQSPD

LNPEP

86

Q9UIQ6
AAGYRPLSASSQSSL

KREMEN2

441

Q8NCW0
LENPRLGSQSTNSSY

JAM2

176

P57087
NRSLSSQSYSPARAA

OTUD7A

801

Q8TE49
LSYSLLGSPNQSLFA

PCDHGC3

606

Q9UN70
ANPAAAAAANLLASY

NOVA2

316

Q9UNW9
SYLLAALGGNSSPSA

RPLP2

6

P05387
YDRHLLPNSGAAATS

RBM4B

271

Q9BQ04
ADYSNQLDPASGTRN

GREB1L

1296

Q9C091
QDGSNLTASQRAYAP

POLA1

1181

P09884
AENYTRPSSRNSASA

LRRFIP2

301

Q9Y608
ASARSPRSYLVAGAN

PGR

396

P06401
STYFDLPQSSRGNNE

TP73

26

O15350
RTSPESLYSDNSNGS

NR1D1

26

P20393
TSGNNLVSPDTDYRA

CCSER2

481

Q9H7U1
ALAASPRQAAYADSG

GATA5

6

Q9BWX5
IAGNPAYRSFSNSLS

IL4R

491

P24394
SLVAYINGSRASPAN

GLIS3

171

Q8NEA6
ATPSALQANLNYGSL

DENND4C

66

Q5VZ89
SRAQSLSYALTSPDA

FLVCR2

281

Q9UPI3
NSAPSLGLGARTYSQ

DNAJC30

26

Q96LL9
DDPSSGNNARLLYSL

CDH19

176

Q9H159
GYPDSLALANNSTLT

DDB1

686

Q16531
SSRSYLALPGNSGED

CNTNAP3B

376

Q96NU0
DFSTLYGSSPLERQN

MED1

656

Q15648
YGSSPLERQNSSSGS

MED1

661

Q15648
TSSTQSLARLGSPDY

NUMA1

1851

Q14980
SANPAAAAANLLATY

NOVA1

351

P51513
SSSAPPRCNNYSANA

MS4A12

251

Q9NXJ0
SSSAAATQRLADYSP

MEX3B

306

Q6ZN04
GPSSQAYDNLSLSDH

USP9X

2141

Q93008
YSFDRNLGQSLSEPA

PLEKHG4

676

Q58EX7
NFSPANLSSTGSRYL

HAUS1

81

Q96CS2
SQGLPASRYNTAADA

NCOR1

1806

O75376
NGYELSPTAAANFTR

PSMB2

71

P49721
NDYDNSPTALSRISS

SIM1

646

P81133
ARSSNYSLPGLTASQ

SIX1

241

Q15475
LSQNRSSESYRPFSG

VPS8

1386

Q8N3P4
APASSYNLDVRGARS

ITGAL

21

P20701
QSRLYSNRELGSSPS

PPP1R15B

191

Q5SWA1
RNVSDYTPLSLAASG

ANKHD1

1151

Q8IWZ3
GLYSNPDLSAAASLA

NCAPD2

1026

Q15021
TGSRYQPLASTASDN

NCAPD2

1321

Q15021
YLGNSLLDSPSQSNS

C12orf56

251

Q8IXR9
SSPTRNLNGAYLTEG

USP16

551

Q9Y5T5
SLRSQGYNSSQDLPS

SEMA4G

381

Q9NTN9
RSLDANSSGRLPDAY

RBMXL3

746

Q8N7X1
SLDANSGGRSPNAYS

RBMXL3

786

Q8N7X1
SEGLNNLSSPGSYQR

SLC36A1

26

Q7Z2H8
SNSLGRSPSASAYLT

IGSF9B

306

Q9UPX0
SSSLNSGNYLNPACR

SCML2

546

Q9UQR0
RYGSAAALPSNSFTS

IGHMBP2

71

P38935
SSSDALQGRYAAPEL

SERINC5

336

Q86VE9
GSQALLLRTPYSSDN

WT1

211

P19544
NLGSSDPSLRSAAYN

NF1

1861

P21359
RSLSNPDYSGTRSNA

TMC5

76

Q6UXY8
GSSSAPNLQDYARTH

PPIP5K2

1071

O43314
NRNSRNSSSGVSPLY

WDR11

391

Q9BZH6
HPSSSNADLLNYRSL

TSNAXIP1

526

Q2TAA8
TPSSYGANLAASLLE

USP2

31

O75604
SSSNLQAPGGSSERY

TET2

356

Q6N021
RSTLYIAASQPGDSA

TRAV21

91

A0A0B4J279
AFPLAASYDTNGLSQ

TNS2

1056

Q63HR2
LFGRPSQGLYSSSAS

UBR5

2066

O95071
HATAGPLYSDNSNIS

UNC79

1441

Q9P2D8
LGASLANSPYATLAS

ZBED4

516

O75132
NSSHGSPDSYSLLLN

MYO5B

1231

Q9ULV0