Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WWE	HUWE1 TRIP12	3.69e-04	12	45	2	PS50918
Domain	WWE-dom	HUWE1 TRIP12	3.69e-04	12	45	2	IPR004170
Domain	WWE	HUWE1 TRIP12	3.69e-04	12	45	2	PF02825
Domain	HECT	HUWE1 TRIP12	1.92e-03	27	45	2	PF00632
Domain	HECTc	HUWE1 TRIP12	1.92e-03	27	45	2	SM00119
Domain	HECT_dom	HUWE1 TRIP12	1.92e-03	27	45	2	IPR000569
Domain	HECT	HUWE1 TRIP12	1.92e-03	27	45	2	PS50237
Domain	IGc2	TYRO3 HSPG2 ISLR LILRA4	2.43e-03	235	45	4	SM00408
Domain	Ig_sub2	TYRO3 HSPG2 ISLR LILRA4	2.43e-03	235	45	4	IPR003598
Domain	-	TYRO3 HSPG2 ISLR IL27RA LILRA4 TMEM81	4.90e-03	663	45	6	2.60.40.10
Domain	IG_LIKE	TYRO3 HSPG2 ISLR LILRA4 TMEM81	6.32e-03	491	45	5	PS50835
Domain	Ig-like_fold	TYRO3 HSPG2 ISLR IL27RA LILRA4 TMEM81	6.63e-03	706	45	6	IPR013783
Domain	Ig-like_dom	TYRO3 HSPG2 ISLR LILRA4 TMEM81	6.99e-03	503	45	5	IPR007110
Domain	LRR_8	PHLPP1 ISLR RSU1	8.07e-03	171	45	3	PF13855
Domain	ARM-type_fold	DOCK3 HUWE1 TRIP12 VPS35	8.85e-03	339	45	4	IPR016024
Domain	Leu-rich_rpt_typical-subtyp	PHLPP1 ISLR RSU1	8.87e-03	177	45	3	IPR003591
Domain	LRR_TYP	PHLPP1 ISLR RSU1	8.87e-03	177	45	3	SM00369
Domain	Ig_I-set	TYRO3 HSPG2 ISLR	1.07e-02	190	45	3	IPR013098
Domain	ig	TYRO3 HSPG2 LILRA4	1.07e-02	190	45	3	PF00047
Domain	Immunoglobulin	TYRO3 HSPG2 LILRA4	1.07e-02	190	45	3	IPR013151
Domain	I-set	TYRO3 HSPG2 ISLR	1.07e-02	190	45	3	PF07679
Domain	LRR	PHLPP1 ISLR RSU1	1.25e-02	201	45	3	PS51450
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	MKI67 KMT2D	5.36e-06	3	47	2	34724040
Pubmed	HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.	HUWE1 TRIP12	1.07e-05	4	47	2	23209776
Pubmed	Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.	MKI67 HUWE1	1.07e-05	4	47	2	33581058
Pubmed	Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.	FGR ITGAL	1.78e-05	5	47	2	19050286
Pubmed	Disruption of the talin gene arrests mouse development at the gastrulation stage.	MKI67 HSPG2	1.78e-05	5	47	2	11084655
Pubmed	TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.	HUWE1 TRIP12	3.74e-05	7	47	2	22561347
Pubmed	Comprehensive Characterization of Tissues Derived from Animals at Different Regenerative Stages: A Comparative Analysis between Fetal and Adult Mouse Skin.	MKI67 HSPG2	3.74e-05	7	47	2	37174615
Pubmed	Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations.	MKI67 SSH3	6.40e-05	9	47	2	27588418
Pubmed	Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7.	HUWE1 TRIP12	6.40e-05	9	47	2	9575161
Pubmed	Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.	MKI67 HSPG2	6.40e-05	9	47	2	18816447
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MKI67 PI4K2A DIDO1 CCAR2 KMT2D HUWE1 TRIP12	7.63e-05	774	47	7	15302935
Pubmed	Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.	MKI67 ISLR	7.99e-05	10	47	2	32128839
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	MKI67 DIDO1 KMT2D FAM120C PARL	9.63e-05	341	47	5	32971831
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	MKI67 HSPG2 CCAR2 HUWE1 TRIP12	1.07e-04	349	47	5	25665578
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	MKI67 CCAR2 KMT2D TBC1D2B	1.13e-04	184	47	4	32908313
Pubmed	Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.	FGR ITGAL	1.17e-04	12	47	2	16872848
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MKI67 TYRO3 HUWE1 VPS35 PSMB5	1.21e-04	358	47	5	32460013
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DIDO1 HSPG2 TRIP12 FAM120C RSU1 VPS35	1.53e-04	601	47	6	33658012
Pubmed	Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes.	MKI67 HSPG2	1.61e-04	14	47	2	16873583
Pubmed	E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.	FGR ITGAL	1.61e-04	14	47	2	20299514
Pubmed	Sufu and Kif7 in limb patterning and development.	MKI67 HOXD12	1.61e-04	14	47	2	25581370
Pubmed	Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.	MKI67 NUMBL	1.61e-04	14	47	2	14687546
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	HUWE1 TRIP12	1.61e-04	14	47	2	27626314
Pubmed	Perlecan maintains the integrity of cartilage and some basement membranes.	MKI67 HSPG2	1.86e-04	15	47	2	10579729
Pubmed	The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.	MKI67 CCAR2	1.86e-04	15	47	2	25882849
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	MKI67 PREB CCAR2 HUWE1 PSMB5	2.02e-04	400	47	5	35013556
Pubmed	The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis.	MKI67 HSPG2	2.12e-04	16	47	2	21350012
Pubmed	VPS35 deficiency in the embryonic cortex leads to prenatal cell loss and abnormal development of axonal connectivity.	MKI67 VPS35	2.12e-04	16	47	2	35367368
Pubmed	UBR5 Acts as an Antiviral Host Factor against MERS-CoV via Promoting Ubiquitination and Degradation of ORF4b.	HUWE1 PSMB5	2.12e-04	16	47	2	35980206
Pubmed	RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.	HUWE1 TRIP12	2.40e-04	17	47	2	37080995
Pubmed	Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina.	MKI67 NUMBL	2.40e-04	17	47	2	23197712
Pubmed	Geminin is required for Hox gene regulation to pattern the developing limb.	MKI67 HOXD12	2.40e-04	17	47	2	32450229
Pubmed	Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.	CCAR2 VPS35 PSMB5	2.42e-04	89	47	3	31267705
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KMT2D TRIP12 FAM120C VPS35	2.84e-04	234	47	4	36243803
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIDO1 CCAR2 TCAF1 HUWE1 NUMBL FAM120C TENM2	2.92e-04	963	47	7	28671696
Pubmed	Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals.	MKI67 NUMBL	3.01e-04	19	47	2	28011038
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	HUWE1 PSMB5	3.01e-04	19	47	2	24743594
Pubmed	Plzf regulates limb and axial skeletal patterning.	MKI67 HOXD12	3.01e-04	19	47	2	10835630
Pubmed	Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf.	MKI67 HOXD12	3.01e-04	19	47	2	37608075
Pubmed	Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.	MKI67 TYRO3	3.01e-04	19	47	2	30212841
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	MKI67 HUWE1	3.69e-04	21	47	2	19686682
Pubmed	DOT1L regulates dystrophin expression and is critical for cardiac function.	MKI67 HSPG2	3.69e-04	21	47	2	21289070
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DOCK3 DIDO1 HUWE1	3.83e-04	104	47	3	9205841
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	KMT2D HUWE1 TRIP12	4.05e-04	106	47	3	31024071
Pubmed	Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.	PI4K2A PHLPP1	4.06e-04	22	47	2	22837474
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CCAR2 KMT2D HUWE1 TRIP12 RSU1	4.20e-04	469	47	5	27634302
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	KMT2D NUMBL	4.44e-04	23	47	2	9225980
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	HSPG2 TCAF1 HUWE1 TRIP12 HPDL	4.71e-04	481	47	5	28190767
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MKI67 PHLPP1 CCAR2 KMT2D HUWE1 NUMBL SSH3	4.88e-04	1049	47	7	27880917
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	MKI67 DIDO1 HUWE1 TRIP12 SSH3	5.77e-04	503	47	5	16964243
Pubmed	Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.	VPS35 TBC1D2B	6.14e-04	27	47	2	22354992
Pubmed	Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation.	MKI67 NUMBL	6.14e-04	27	47	2	21084383
Pubmed	Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.	CCAR2 TENM2	6.14e-04	27	47	2	25133637
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	HSPG2 ITGAL	6.14e-04	27	47	2	31541017
Pubmed	Chondromodulin I is dispensable during enchondral ossification and eye development.	MKI67 HSPG2	6.14e-04	27	47	2	12192060
Pubmed	Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.	CCAR2 HUWE1	6.61e-04	28	47	2	25752541
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	HUWE1 TRIP12	6.61e-04	28	47	2	35474067
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	CCAR2 HUWE1 PSMB5	7.01e-04	128	47	3	28027390
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	MKI67 HSPG2	8.11e-04	31	47	2	22274697
Pubmed	Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control.	MKI67 TYRO3	8.64e-04	32	47	2	27571008
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	HUWE1 TRIP12	9.19e-04	33	47	2	33567268
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	DIDO1 CCAR2 HUWE1	1.01e-03	145	47	3	28846114
Pubmed	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.	MKI67 HSPG2	1.03e-03	35	47	2	18676816
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	MKI67 HUWE1 TRIP12 PSMB5	1.06e-03	333	47	4	36779763
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	CCAR2 HUWE1	1.09e-03	36	47	2	35379950
Pubmed	GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.	MKI67 HOXD12	1.16e-03	37	47	2	22465667
Pubmed	Nuclear High Mobility Group A2 (HMGA2) Interactome Revealed by Biotin Proximity Labeling.	MKI67 TRIP12	1.16e-03	37	47	2	36835656
Pubmed	Functional proteomics mapping of a human signaling pathway.	HSPG2 KMT2D HUWE1 TRIP12 VPS35	1.19e-03	591	47	5	15231748
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	MKI67 HSPG2	1.22e-03	38	47	2	29743679
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	MKI67 KMT2D	1.22e-03	38	47	2	27930960
Cytoband	3q27.1	VWA5B2 MCF2L2 PARL	2.89e-06	27	47	3	3q27.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	VWA5B2 MCF2L2 PARL	3.14e-04	128	47	3	chr3q27
Cytoband	7q34	TRBV5-4 LLCFC1 TRBV5-8	6.82e-04	167	47	3	7q34
Cytoband	Xp11.22	HUWE1 FAM120C	1.42e-03	54	47	2	Xp11.22
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D NUMBL	8.33e-04	25	31	2	775
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TYRO3 HSPG2 ISLR	2.59e-03	161	31	3	593
GeneFamily	Immunoglobulin like domain containing	TYRO3 HSPG2 TMEM81	4.32e-03	193	31	3	594
GeneFamily	T cell receptor beta locus at 7q34	TRBV5-4 TRBV5-8	9.72e-03	87	31	2	372
GeneFamily	PHD finger proteins	DIDO1 KMT2D	1.04e-02	90	31	2	88
Disease	brain cancer (implicated_via_orthology)	NUMBL VPS35	6.29e-04	26	42	2	DOID:1319 (implicated_via_orthology)
Disease	suicide behaviour measurement	MKI67 GABRP	1.72e-03	43	42	2	EFO_0006882
Disease	urinary albumin to creatinine ratio	TYRO3 RSU1 AK5	2.12e-03	179	42	3	EFO_0007778
Disease	alcohol use disorder measurement	PHLPP1 PLSCR5 TENM2	3.51e-03	214	42	3	EFO_0009458
Disease	smooth surface dental caries	GABRP ITGAL	3.54e-03	62	42	2	EFO_0006339
Disease	breast carcinoma (is_marker_for)	KMT2D PARL	4.00e-03	66	42	2	DOID:3459 (is_marker_for)
Disease	visceral adipose tissue measurement	TRIP12 RSU1 AK5 PARL	4.78e-03	481	42	4	EFO_0004765
Disease	Squamous cell carcinoma of esophagus	DIDO1 KMT2D	8.12e-03	95	42	2	C0279626

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQRINPLPGGRNFSG	CCAR2	6	Q8N163
FLAQPLGAFVRLRNP	SLC4A9	236	Q96Q91
PLEQLVRQGSFRGFP	NUMBL	296	Q9Y6R0
PQGFQFRRLGTVPQF	HSPG2	181	P98160
RPGRQPQAGLSQANF	LILRA4	266	P59901
RQLLSPGNPQGAFLI	FGR	156	P09769
TLPPLNGGQSRRSFL	AK5	66	Q9Y6K8
QLEINFGNLPRPGRG	HABP4	356	Q5JVS0
QPRFQAFANGSLLIP	ISLR	301	O14498
PGNLQLIFILRPSRF	MCF2L2	126	Q86YR7
QPFGQLKRPRRNGLG	GPATCH3	461	Q96I76
AQNQRRGLPGFLPGA	PLSCR5	6	A0PG75
LFQRTRPQGSAGPLQ	IL27RA	26	Q6UWB1
LDQPGNLPGSNRRLQ	MKI67	1806	P46013
GGPFQRRLPGLQLRQ	GAL3ST4	36	Q96RP7
LPGGVQNFPQFSALR	HUWE1	1226	Q7Z6Z7
PAGQPLARNLQRLFG	HPDL	16	Q96IR7
QRFNRIGLPPKVGSF	PI4K2A	246	Q9BTU6
RFLVRLNKNGGPRNP	DOCK3	251	Q8IZD9
SLPVGPSFLGFRNNR	FAM120C	411	Q9NX05
FSNLRPNGGQLAALP	HOXD12	26	P35452
PFQFGGQRRPLLSQL	DIDO1	1886	Q9BTC0
PRFTNQRAPAPLQFG	DIDO1	1976	Q9BTC0
VFSGGPLRRTFPNIQ	LLCFC1	101	Q96L11
FLRPNFGGEPVQIAL	GABRP	51	O00591
AVLTPPQLLGRRFNF	PARL	31	Q9H300
NRLNTLPRGFGSLPA	RSU1	96	Q15404
RLPPQATFQVLRGNG	SUSD3	36	Q96L08
LARFPGNLLLNPFGI	TCAF1	376	Q9Y4C2
LPVFGSVRNRGAPFQ	RNF165	11	Q6ZSG1
FGFQLSNIIPGFPRA	TENM2	2486	Q9NT68
LFRQNLQGPMLQGRP	ITGAL	131	P20701
ERPGRSQAFLFQPQR	NPFF	61	O15130
RPNPGFLRQLQIYQG	SSH3	451	Q8TE77
RGNFPPRFSGRQFPN	TRBV5-8	76	A0A5A2
RFGQVPDQPAGLRLF	PREB	251	Q9HCU5
APRLFSGGLQNFLLP	TMEM247	156	A6NEH6
GNQRIRFTLPPLVFA	VPS35	521	Q96QK1
RGNFPPRFSGLQFPN	TRBV5-4	76	A0A0C4DH59
LGRNLSGQPNFPCRV	TM9SF3	416	Q9HD45
FGLRVLPPNLVNLNF	TMEM81	176	Q6P7N7
RGQAYFLRPGQRLQP	VWA5B2	496	Q8N398
FLRQNPSLPAARGLN	PHLPP1	671	O60346
VLERPLPVNQRGFFG	PSMB5	6	P28074
RGGVVPLQQFLQRFP	VRTN	326	Q9H8Y1
QRLFLQFVTGSPRLP	TRIP12	1911	Q14669
FGDLNPFPLRQIRNR	TBC1D2B	906	Q9UPU7
PNGFKRQCLLNRPFS	THEGL	276	P0DJG4
GENPFNLPLQTLIRF	TYRO3	621	Q06418
LQRPFLQGGLPLGNL	KMT2D	1921	O14686