Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Thin corpus callosum	SOX3 AKT3 HDAC4 CENPF RBL2 USP9X MPDZ U2AF2 SPG11 NHLRC2 RNF220 RAB34 KANSL1 SACS BUB1 INTS11 PYCR1 MACF1 KDM6A UNC80	9.89e-06	868	44	20	HP:0033725
HumanPheno	Abnormal corpus callosum morphology	SOX3 AKT3 HDAC4 CENPF RBL2 USP9X MPDZ U2AF2 SPG11 NHLRC2 RNF220 RAB34 KANSL1 SACS BUB1 INTS11 PYCR1 MACF1 KDM6A UNC80	3.21e-05	937	44	20	HP:0001273
HumanPheno	Gaze-evoked nystagmus	SOX3 RBL2 SPG11 VPS13D SACS	9.61e-05	55	44	5	HP:0000640
HumanPheno	Aplasia/Hypoplasia of the corpus callosum	SOX3 AKT3 CENPF USP9X MPDZ U2AF2 SPG11 NHLRC2 RAB34 KANSL1 SACS BUB1 INTS11 PYCR1 MACF1 KDM6A UNC80	1.19e-04	772	44	17	HP:0007370
HumanPheno	Abnormal cerebral white matter morphology	SOX3 AKT3 HDAC4 CENPF RBL2 USP9X MPDZ U2AF2 SPG11 NHLRC2 RNF220 VPS13D RAB34 KANSL1 SACS BUB1 INTS11 PYCR1 MACF1 KDM6A UNC80	1.23e-04	1114	44	21	HP:0002500
HumanPheno	Abnormal cerebral subcortex morphology	SOX3 AKT3 HDAC4 ATR CENPF RBL2 USP9X MPDZ U2AF2 SPG11 NHLRC2 RNF220 VPS13D RAB34 KANSL1 SACS BUB1 INTS11 PYCR1 MACF1 KDM6A UNC80	1.25e-04	1207	44	22	HP:0010993
Domain	FAM21	WASHC2C WASHC2A	4.09e-05	2	120	2	IPR027308
Domain	CAP-ZIP_m	WASHC2C WASHC2A	1.22e-04	3	120	2	PF15255
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	1.22e-04	3	120	2	IPR029341
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	WASHC2C ATR ARID4A CKAP5 CHAMP1 PWP1 JUN EIF2D KANSL1 ZNF638 TLN2 SCRIB COIL KDM6A ANKS1A	1.08e-07	774	123	15	15302935
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RBL2 USP9X CKAP5 IFIT5 ZNF365 MTMR10 FAN1 RNF220 PTPN13 SACS OSBPL8 MACF1 TLN2 TMEM131 SCRIB CHPF DNAJA1 KDM6A LGI1	1.35e-07	1285	123	19	35914814
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PLOD3 USP9X MTMR10 FAN1 PTPN13 SCCPDH SUGT1 INTS11 ZNF638 PYCR1 INTS4 LRP6 TTI1 SCRIB COIL DNAJA1 KDM6A	1.84e-07	1049	123	17	27880917
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NCKAP1 CENPF USP9X CKAP5 U2AF2 NUP205 PWP1 OSBPL8 ZNF638 MACF1 COIL DNAJA1 RBM34	5.95e-07	653	123	13	22586326
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ATR CKAP5 U2AF2 EIF2D KANSL1 SUGT1 BUB1 ZNF638 MACF1 TLN2 SCRIB DNAJA1	1.15e-06	582	123	12	20467437
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	NCKAP1 USP9X CKAP5 MPDZ IFIT5 ARFGAP2 PTPN13 OSBPL8 LRP6 MACF1 SCRIB DNAJA1 ANKS1A	1.46e-06	708	123	13	39231216
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CENPF USP9X CHAMP1 SCCPDH SACS OSBPL8 TTI1 MACF1 TLN2 SCRIB ANKS1A	1.69e-06	498	123	11	36634849
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	WASHC2C CENPF USP9X TACC2 CHAMP1 SUGT1 ZNF638 TLN2 TMEM131 SCRIB COIL	1.87e-06	503	123	11	16964243
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WASHC2C NCKAP1 CKAP5 WASHC2A ZNF365 KANSL1 KLHL13 MACF1 SCRIB MAPKBP1	2.00e-06	407	123	10	12693553
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	HDAC4 ATR USP9X TTBK2 KNDC1	2.01e-06	58	123	5	31067491
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	WASHC2C USP9X HMGXB4 CKAP5 U2AF2 CHAMP1 ZNF638 TTI1 DNAJA1	3.00e-06	332	123	9	32786267
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PLOD3 CENPF HMGXB4 CHAMP1 WASHC2A JUN OSBPL8 MACF1 TLN2 NEXN	7.37e-06	472	123	10	38943005
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	CENPF USP9X CHAMP1 OSBPL8 ZNF638 INTS4 MACF1 GMPPA	7.59e-06	281	123	8	24163370
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	MPDZ WASHC2A VPS13D PTPN13 MACF1 SCRIB ANKS1A	1.01e-05	209	123	7	36779422
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PLOD3 NCKAP1 CENPF USP9X SPG11 VPS13D TRANK1 DNAH12 OSBPL8 RBM34	1.15e-05	497	123	10	36774506
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HDAC4 NCKAP1 CKAP5 MPDZ DENND2B ARFGAP2 VPS13D PTPN13 OSBPL8 MACF1 SCRIB OTOG ANKS1A	1.20e-05	861	123	13	36931259
Pubmed	Identification of a novel Rev-interacting cellular protein.	WASHC2C WASHC2A	1.24e-05	2	123	2	15847701
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	1.24e-05	2	123	2	20827171
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	1.24e-05	2	123	2	36717248
Pubmed	Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.	CENPF BUB1	1.24e-05	2	123	2	20660191
Pubmed	Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90.	SUGT1 SCRIB	1.24e-05	2	123	2	22623728
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ATR ARID4A CENPF HMGXB4 CKAP5 U2AF2 CHAMP1 ZSCAN29 JUN KANSL1 INTS11 ZNF638 INTS4 COIL DNAJA1 KDM6A	1.38e-05	1294	123	16	30804502
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	WASHC2C CENPF CKAP5 TACC2 CHAMP1 WASHC2A TTBK2 KANSL1 SUGT1 BUB1 TLN2 SCRIB COIL DNAJA1 NEXN	1.48e-05	1155	123	15	20360068
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	ATR CENPF U2AF2 CHAMP1 ARFGAP2 EIF2D SCRIB COIL RBM34	1.62e-05	410	123	9	26949251
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	TDRD5 NIBAN1 PTGFR FCRL6 AMIGO1 TRIM45 JUN RNF220 VPS13D SCCPDH INTS11 MACF1 NR0B2 RBM34	1.79e-05	1031	123	14	16710414
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NCKAP1 CKAP5 U2AF2 NUP205 EIF2D RAB34 KANSL1 SUGT1 INTS11 ZNF638 PYCR1 MACF1 SCRIB DNAJA1 NEXN RBM34	2.38e-05	1353	123	16	29467282
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	CENPF USP9X CKAP5 IFIT5 JUN SACS MACF1 SCRIB	2.52e-05	332	123	8	37433992
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	HMGXB4 U2AF2 CHAMP1 NUP205 ZSCAN29 PWP1 PTPN13 SACS INTS11 ZNF638 INTS4 MACF1 COIL DNAJA1	3.03e-05	1082	123	14	38697112
Pubmed	HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers.	HDAC4 JUN	3.71e-05	3	123	2	33966634
Pubmed	Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.	INTS11 INTS4	3.71e-05	3	123	2	29471365
Pubmed	Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.	WASHC2A JUN	3.71e-05	3	123	2	29735545
Pubmed	The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.	RBL2 KDM6A	3.71e-05	3	123	2	20650264
Pubmed	TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.	TRIM45 JUN	3.71e-05	3	123	2	15351693
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CKAP5 PTPN13 ZNF638 MACF1 TMEM131 SCRIB ANKS1A	4.40e-05	263	123	7	34702444
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	USP9X MPDZ PTPN13 GTPBP8 SUGT1 SCRIB DNAJA1	5.19e-05	270	123	7	24366813
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	WASHC2C NCKAP1 USP9X CKAP5 TACC2 WASHC2A ARFGAP2 SUGT1 KNDC1 OSBPL8 MACF1 TLN2 COIL DNAJA1	5.28e-05	1139	123	14	36417873
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	CENPF HMGXB4 PWP1 RAB34 KDM6A	6.75e-05	119	123	5	23508102
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AMIGO1 FAN1 VPS13D SACS OSBPL8 DISP3 MACF1 PLEKHH2 UNC80	6.78e-05	493	123	9	15368895
Pubmed	Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.	LRRC8C WASHC2C WASHC2A	7.26e-05	23	123	3	31748650
Pubmed	Ras protects Rb family null fibroblasts from cell death: a role for AP-1.	RBL2 JUN	7.41e-05	4	123	2	14688262
Pubmed	Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.	AKT3 JUN	7.41e-05	4	123	2	19435822
Pubmed	Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.	MPDZ PTPN13	7.41e-05	4	123	2	14516276
Pubmed	LEK1 is a potential inhibitor of pocket protein-mediated cellular processes.	CENPF RBL2	7.41e-05	4	123	2	14555653
Pubmed	Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells.	HDAC4 JUN	7.41e-05	4	123	2	19389706
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NIBAN1 NCKAP1 U2AF2 PTPN13 SACS INTS11 SCRIB COIL	9.30e-05	400	123	8	35013556
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	WASHC2C HMGXB4 CKAP5 U2AF2 WASHC2A SCRIB	1.21e-04	215	123	6	35973513
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	HDAC4 NCKAP1 CENPF USP9X CKAP5 MPDZ MACF1 TLN2 SCRIB DNAJA1 LGI1 ANKS1A	1.64e-04	963	123	12	28671696
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	MASP1 NIBAN1 NCKAP1 USP9X CKAP5 SCCPDH PYCR1	1.64e-04	325	123	7	36168628
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	ATR USP9X CKAP5 SUGT1 DNAJA1	1.71e-04	145	123	5	28846114
Pubmed	Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.	MTMR10 FAN1	1.84e-04	6	123	2	32876667
Pubmed	Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.	PTGFR TRANK1	1.84e-04	6	123	2	22182935
Pubmed	A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.	HDAC4 JUN	1.84e-04	6	123	2	35076395
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CKAP5 NUP205 PWP1 OSBPL8 ZNF638 COIL RBM34	1.87e-04	332	123	7	25693804
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	ARID4A CKAP5 IFIT5 NHLRC2 ARFGAP2 VPS13D SUGT1 OSBPL8 TMEM131	1.96e-04	568	123	9	37774976
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	CKAP5 IFIT5 WASHC2A ARFGAP2 SUGT1 SCRIB DNAJA1 ANKS1A	2.05e-04	449	123	8	31732153
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	NCKAP1 CENPF U2AF2 CHAMP1 NUP205 SUGT1 INTS11 SCRIB DNAJA1 GMPPA	2.09e-04	704	123	10	29955894
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	WASHC2C NCKAP1 CKAP5 WASHC2A NUP205 ARFGAP2 EIF2D SUGT1 TMEM131 DNAJA1 ANKS1A	2.31e-04	853	123	11	28718761
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	RBL2 CKAP5 U2AF2	2.38e-04	34	123	3	12549820
Pubmed	Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.	ARID4A RBL2	2.58e-04	7	123	2	15750587
Pubmed	Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.	HDAC4 NR0B2	2.58e-04	7	123	2	17210713
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	NCKAP1 MPDZ MACF1 TLN2 LGI1 ANKS1A	2.80e-04	251	123	6	27507650
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NIBAN1 CENPF USP9X CKAP5 U2AF2 NUP205 SACS ZNF638 MACF1 SCRIB COIL DNAJA1	2.87e-04	1024	123	12	24711643
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	MPDZ SPG11 NHLRC2 WASHC2A SUGT1 OSBPL8 ZNF638 TMEM131 DNAJA1 ANKS1A	2.88e-04	733	123	10	34672954
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	USP9X SACS PYCR1 COIL	2.88e-04	89	123	4	36861887
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	LRRC8C WASHC2C HDAC4 USP9X MPDZ WASHC2A KANSL1 TLN2	2.99e-04	475	123	8	31040226
Pubmed	A FAM21-containing WASH complex regulates retromer-dependent sorting.	WASHC2C WASHC2A	3.43e-04	8	123	2	19922874
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	ATR TTI1	3.43e-04	8	123	2	20810650
Pubmed	TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.	CKAP5 TTBK2	3.43e-04	8	123	2	26323690
Pubmed	Defining the molecular character of the developing and adult kidney podocyte.	TDRD5 JUN PLEKHH2	3.59e-04	39	123	3	21931791
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	NIBAN1 ATR CKAP5 ARFGAP2 ZNF638 COIL RBM34	3.60e-04	370	123	7	22922362
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	NCKAP1 NUP205 PWP1 DNAH12 MACF1 DNAJA1 NEXN RBM34	3.98e-04	496	123	8	31343991
Pubmed	A protein interaction landscape of breast cancer.	AKT3 PLOD3 USP9X PWP1 SCCPDH RAB34 PYCR1 MACF1 RBM34	4.38e-04	634	123	9	34591612
Pubmed	Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways.	AKT3 JUN	4.39e-04	9	123	2	24225433
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	ATR USP9X MTMR10 NUP205 FAN1 EIF2D RAB34 SUGT1 GMPPA RBM34 VCPKMT	4.83e-04	931	123	11	27432908
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	HDAC4 DENND2B ZNF638 ANKS1A	4.84e-04	102	123	4	15778465
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	WASHC2C CKAP5 TACC2 CHAMP1 PTPN13 SUGT1 ZNF638 MACF1 SCRIB COIL ANKS1A	4.96e-04	934	123	11	33916271
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	WASHC2C NHLRC2 WASHC2A TRIM45	5.03e-04	103	123	4	29539633
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP9X WASHC2A PWP1 INTS11 MACF1 DNAJA1	5.18e-04	282	123	6	23667531
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ATR MPDZ ZZEF1 PWP1 ARFGAP2 EIF2D BUB1 ZNF638 SCRIB	5.24e-04	650	123	9	38777146
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	IFIT5 U2AF2 CHAMP1 JUN ZNF638 COIL	5.28e-04	283	123	6	30585729
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ATR NCKAP1 CENPF USP9X CKAP5 U2AF2 NUP205 PWP1 INTS11 PYCR1 TLN2 COIL DNAJA1 RBM34	5.28e-04	1425	123	14	30948266
Pubmed	Human transcription factor protein interaction networks.	ARID4A USP9X HMGXB4 WASHC2A NUP205 PWP1 JUN KANSL1 ZNF638 SLX4IP LRP6 DNAJA1 KDM6A RBM34	5.43e-04	1429	123	14	35140242
Pubmed	Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.	MPDZ SCRIB	5.48e-04	10	123	2	19071123
Pubmed	WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1).	SUGT1 SCRIB	5.48e-04	10	123	2	24145035
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	CKAP5 PTPN13 SCRIB ANKS1A	5.60e-04	106	123	4	38891874
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HDAC4 ARID4A USP9X SUGT1 DNAJA1 RBM34	5.89e-04	289	123	6	23752268
Pubmed	Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.	INTS11 INTS4	6.68e-04	11	123	2	23904267
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	ATR TTI1	6.68e-04	11	123	2	20427287
Pubmed	HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors.	AKT3 JUN	6.68e-04	11	123	2	24658403
Pubmed	Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes.	HDAC4 NR0B2	6.68e-04	11	123	2	27485016
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	LRP6 MACF1	6.68e-04	11	123	2	16815997
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP9X CKAP5 U2AF2 PWP1 JUN KANSL1 BUB1 OSBPL8 PYCR1 DNAJA1 RBM34	6.83e-04	971	123	11	33306668
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	NCKAP1 USP9X CKAP5 NUP205 TLN2 DNAJA1 ANKS1A	7.41e-04	418	123	7	32552912
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	USP9X MPDZ CHAMP1 PTPN13 SUGT1 SCRIB COIL KDM6A	7.73e-04	549	123	8	38280479
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	NUP205 ZNF638 LRP6 SCRIB NEXN	7.81e-04	202	123	5	24639526
Pubmed	The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.	WASHC2C WASHC2A	8.00e-04	12	123	2	19922875
Pubmed	Developmental activities of the complement pathway in migrating neurons.	MASP1 C5AR1	8.00e-04	12	123	2	28462915
Pubmed	Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.	WASHC2C WASHC2A	8.00e-04	12	123	2	27390154
Pubmed	Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).	USP9X TTI1	8.00e-04	12	123	2	22544753
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PLOD3 MPDZ SPG11 WASHC2A PTPN13 SUGT1 SACS OSBPL8 PYCR1 MACF1 TMEM131 SCRIB DNAJA1 RBM34	8.00e-04	1487	123	14	33957083
Cytoband	2q35	GLB1L CHPF GMPPA UNC80	6.31e-05	79	123	4	2q35
Cytoband	1p32-p31	JUN MACF1	2.53e-04	9	123	2	1p32-p31
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	PLA2G4D ZSCAN29 TTBK2 MAPKBP1	6.82e-04	147	123	4	chr15q15
Cytoband	18q22.3	PTGR3 TSHZ1	7.31e-04	15	123	2	18q22.3
GeneFamily	WASH complex	WASHC2C WASHC2A	2.87e-04	6	80	2	1331
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	MAN2A1 HDAC4 ATR NCKAP1 ARID4A CENPF USP9X HMGXB4 CKAP5 SPG11 ZZEF1 DENND2B JUN PTPN13 SACS OSBPL8 ZNF638 MACF1 TMEM131 ANKS1A	2.41e-09	856	121	20	M4500
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	MAN2A1 ATR CENPF USP9X HMGXB4 CKAP5 JUN OSBPL8 ZNF638 TMEM131 ANKS1A	1.10e-05	466	121	11	M13522
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 HDAC4 AQP2 GSTA3 PTPN13 TLN2 C5AR1	7.01e-07	180	123	7	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X KIF12 JUN TSHZ1 CHPF GMPPA UNC80	1.12e-06	193	123	7	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCCPDH PYCR1 TLN2 TMEM39A CHPF VCPKMT	9.57e-06	176	123	6	2e9073166da4d9fae70ba4f3fdcad35523caf7cd
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	AKT3 MAN2A1 KANSL1 MACF1 KDM6A RBM34	1.12e-05	181	123	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ARID4A CHAMP1 VPS13D TRANK1 TMEM131 GP5	1.31e-05	186	123	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	CKAP5 NME9 ACOX2 VPS13D KNDC1 DLEC1	1.39e-05	188	123	6	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 HDAC4 AQP2 PTGFR MTMR10 PTPN13	1.48e-05	190	123	6	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MAN2A1 KANSL1 ZNF638 LRP6 KDM6A ADGRD1	1.57e-05	192	123	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X KIF12 TSHZ1 CHPF GMPPA UNC80	1.62e-05	193	123	6	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	droplet-Pancreas-Endocrine-21m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF12 JUN TSHZ1 CHPF GMPPA UNC80	1.66e-05	194	123	6	3a3ecedcdc7691cf21775818b598208fcb980c29
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF12 JUN TSHZ1 CHPF GMPPA UNC80	1.66e-05	194	123	6	0b023de48ed8a550d169bbe954881eb04bf4f981
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NIBAN1 NCKAP1 MUC16 C5AR1 UNC80 LGI1	1.71e-05	195	123	6	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NIBAN1 NCKAP1 MUC16 C5AR1 UNC80 LGI1	1.71e-05	195	123	6	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NIBAN1 RBL2 PTPN13 MACF1 TMEM39A DNAJA1	1.76e-05	196	123	6	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	PLOD3 USP9X SPG11 JUN C5AR1 DNAJA1	1.97e-05	200	123	6	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	LRRC8C PLOD3 ZNF385A EIF2D TTI1 UNC80	1.97e-05	200	123	6	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	TACC2 PTGR3 RAB34 KLHL13 TSHZ1 NEXN	1.97e-05	200	123	6	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	TACC2 PTGR3 RAB34 KLHL13 TSHZ1 NEXN	1.97e-05	200	123	6	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPF CKAP5 BUB1 PKIB C5AR1	4.68e-05	142	123	5	be63c48794a227ea55978524c0f5935342fc455e
Disease	adenoid cystic carcinoma (is_implicated_in)	ATR KDM6A	1.49e-04	5	115	2	DOID:0080202 (is_implicated_in)
Disease	progression free survival, methylcobalamin deficiency type cblE, ovarian carcinoma, response to cisplatin	KCTD14 INTS4	2.24e-04	6	115	2	EFO_0001075, EFO_0004920, GO_0072718, MONDO_0009354
Disease	colon cancer (is_implicated_in)	AKT3 ATR PTPN13	3.75e-04	36	115	3	DOID:219 (is_implicated_in)
Disease	Inherited neuropathies	SPG11 TTBK2 SACS	5.13e-04	40	115	3	C0598589
Disease	ovarian neoplasm	ATR RBL2 MUC16 KANSL1	1.90e-03	134	115	4	C0919267
Disease	oral squamous cell carcinoma (is_marker_for)	JUN PTPN13 BARHL2	1.93e-03	63	115	3	DOID:0050866 (is_marker_for)
Disease	methylcobalamin deficiency type cblE, overall survival, ovarian carcinoma, response to cisplatin	KCTD14 INTS4	1.97e-03	17	115	2	EFO_0000638, EFO_0001075, GO_0072718, MONDO_0009354
Disease	Malignant neoplasm of ovary	ATR RBL2 MUC16 KANSL1	2.06e-03	137	115	4	C1140680
Disease	susceptibility to cold sores measurement	AKT3 MUC16 PKIB	2.11e-03	65	115	3	EFO_0008402
Disease	Chronic myeloproliferative disorder	ATR CENPF	2.47e-03	19	115	2	C1292778
Disease	Seckel syndrome	ATR CENPF	3.31e-03	22	115	2	C0265202

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVSKFPEGLFISKLL	TDRD5	306	Q8NAT2
KRKVLEAPSGALSLL	TMEM59L	136	Q9UK28
GTLTFSKELPKSLAG	ZNF385A	311	Q96PM9
GYSKLSGLPSLVTKL	ACOX2	416	Q99424
GAKLPKLTLLDLSSN	AMIGO1	181	Q86WK6
PAKSLSERLAVLKGL	AQP2	226	P41181
KSSLLRSEILFGAPL	DISP3	391	Q9P2K9
KKADLPLLTSTFLGS	EIF2D	281	P41214
ELSTKPGLQKASIFL	ARID4A	241	P29374
LIFKLLSGLSKPVSS	BUB1	746	O43683
TKTFLKAVGEILLLP	ADGRD1	321	Q6QNK2
DLLGTSPKASLELKS	ARFGAP2	196	Q8N6H7
LPAVEKLLSGKRLSS	ANKS1A	16	Q92625
KKASGTLAPLDFLLQ	SLC22A18AS	21	Q8N1D0
SFLEPSSPTFLLLKK	C5AR1	266	P21730
NGFLSPDKLSLLEKL	DNAJA1	331	P31689
PFLVGLLSSSLPKLK	DENND2B	946	P78524
SDAKSLLSGLLIKDP	AKT3	371	Q9Y243
FRSLIPAEGTLSKKL	RBM34	216	P42696
PSSVLLFLVGSKKDL	RAB34	156	Q9BZG1
KIASLLGLLSKTAGF	INTS4	91	Q96HW7
GTSDLPLKLEALSVK	PKIB	41	Q9C010
SLSPGKLKLTFEELE	NEXN	241	Q0ZGT2
LLKTLAAFGKSPEIA	NUP205	646	Q92621
LLGFELKKPVSTTNL	NUP205	1006	Q92621
ILDKVKLDSPAGTAL	PYCR1	286	P32322
FDKSKALRISTPLTG	RBL2	391	Q08999
VILAGSPTELLKKFV	PLOD3	116	O60568
LDSLGPKFKKLAEIS	DSG3	846	P32926
ESVLQGLLKPLFKST	MUC16	13196	Q8WXI7
SLEPLLKTLKDISGF	VCPKMT	151	Q9H867
KKLLGSLASVFVRLP	HDAC4	736	P56524
SKLFRTKVLLAPLGD	MAN2A1	411	Q16706
EELGSFLTSLLKKGL	INTS11	581	Q5TA45
SILGTPLSKFLSGAK	MTMR10	751	Q9NXD2
KNSDLLTSPDVGLLK	JUN	56	P05412
PFRDSKLTKLLADSL	KIF12	311	Q96FN5
ALKLDLGLFSTKTLV	KDM6A	976	O15550
KLSLKGSQVLFTPAS	FCRL6	291	Q6DN72
DSSLISNFPLLKALK	GSTA3	171	Q16772
KSKASFLLLASGLVI	PTGFR	61	P43088
ADKLAIKLGFSLTPS	COIL	291	P38432
KDPKVLAATSLTGLL	DNAH12	951	Q6ZR08
VKLEGKKSPLSSILF	KANSL1	261	Q7Z3B3
TLKGKPIRLTADLSA	L1RE1	241	Q9UN81
LSKPIALALDSRLGK	LRP6	1101	O75581
LGLSKAAVILPKDAS	LCN10	166	Q6JVE6
DLLKAITSPLAAGSK	HMGXB4	111	Q9UGU5
LLPKKASGFSLSLEI	OVOS2	1306	Q6IE36
SSLGTVFPLKKARDL	PCDHB15	146	Q9Y5E8
SILKKILLEEPSSSG	NR0B2	116	Q15466
VGKSSLIKALFSLAP	GTPBP8	121	Q8N3Z3
ELAKLPAGALTSIKR	PNPLA7	666	Q6ZV29
FKLRLDLPSGSKLTE	NHLRC2	616	Q8NBF2
AKLFLAKPITPSSLG	PLEKHH2	1351	Q8IVE3
KEFLALASSSLLKIG	NCKAP1	1056	Q9Y2A7
FIDGILASKFPTTKL	MACF1	7066	Q9UPN3
SAILEFKLKPFLGSS	OSBPL8	601	Q9BZF1
AFLKRPELGLTLTKL	GYG2	106	O15488
SESLFKDGKLLPAIT	GMPPA	371	Q96IJ6
ALSEFGSKIILLKPI	CKAP5	151	Q14008
SKSPAIFGVLTKELL	ATR	136	Q13535
LLEYGSPKIKSLAIS	ATR	236	Q13535
LSGRLAKASTPALAK	CCDC71	121	Q8IV32
VKSFSLGPLRKAVTL	IFIT5	196	Q13325
KNFPALLSTGEFLKL	KLHL13	221	Q9P2N7
KLLPTNTDIFGLKIS	BPIFA2	91	Q96DR5
AAQKLALSPLSLGKE	CENPF	3016	P49454
LASPKKLLEDTLFPS	CHAMP1	601	Q96JM3
LFLTGKLGSKLDILV	GLB1L	461	Q6UWU2
SFLIKDILGDSKPLA	BARHL2	141	Q9NY43
SDLLSPSDFKIILGK	MASP1	506	P48740
KPDTGLKLLASASRD	MAPKBP1	531	O60336
PGTFSDLIKLKTLRL	GP5	91	P40197
SPLTAFLKLTSLGFI	GPR85	16	P60893
LLGKLEDFISSKILP	KNDC1	1341	Q76NI1
FSPLSGDIKLSVLAL	DEFB115	6	Q30KQ5
AILVEVLFSPKSLGK	DLEC1	551	Q9Y238
KALGIFTKPSLSAVL	SACS	1211	Q9NZJ4
LLTKEGAADSPLRLK	LILRA3	356	Q8N6C8
FISLDLPRSILTKKG	PTPN13	551	Q12923
GLVALESLAKPSSFL	OTOG	1356	Q6ZRI0
ISEVLPGKLLRKTFS	PLA2G4D	111	Q86XP0
LLSAPELKSLAKTFH	FAN1	471	Q9Y2M0
FALIPTALDALSKEK	USP9X	1296	Q93008
TLLKKDKYSLPSGLL	SOX3	216	P41225
KPLLGFVSKLTSGTA	TRIM45	6	Q9H8W5
LEKAALKLGRPTLSS	SCCPDH	56	Q8NBX0
TPKSLLLSASIKREG	RNF220	266	Q5VTB9
NLLKSLPASLSFLVK	SCRIB	161	Q14160
TTLGTLRKFPGSKLA	KCTD14	46	Q9BQ13
DGLTLKLFLKRTAPF	SLC35F4	241	A4IF30
DPGLLLKQDLAKTTS	SLX4IP	341	Q5VYV7
LSKKHPLDTLFLLAG	CHPF	601	Q8IZ52
LKPSALKDVLASGFL	TTPAL	116	Q9BTX7
KKLDPSGTLKTALLD	SPG11	2191	Q96JI7
DSLEPVFTLGSKLSK	PWP1	226	Q13610
IPLKDPLLFKSASDT	UHRF1BP1L	941	A0JNW5
LSALLDSAEKLAPGK	UNC80	951	Q8N2C7
TDLVTSSELLKPGKL	ZNF365	71	Q70YC5
DKLSLLKSVLQSPLF	MPDZ	31	O75970
EPITASGSLKALRKL	NIBAN1	701	Q9BZQ8
VGGLAKSKDFLSLLL	TMEM39A	231	Q9NV64
PGSSLRFKITEALLK	TMEM131	986	Q92545
KDTSAGKESILPALL	TTBK2	476	Q6IQ55
LFAGTKKTKLLEPSV	WASHC2C	861	Q9Y4E1
AASLKLFAGSLAPLL	TACC2	1281	O95359
FSEKELSALVKLPSG	SUGT1	201	Q9Y2Z0
LALLFPSLKFSDKDT	NME9	291	Q86XW9
AGTLPAKLLKKSASV	PTGR3	286	Q8N4Q0
ASLGFLVAKPALISL	ZNF517	51	Q6ZMY9
LFAGTKKTKLLEPSV	WASHC2A	861	Q641Q2
KELLTSFGPLKAFNL	U2AF2	276	P26368
STKFELLSLGATLKL	ZGRF1	1591	Q86YA3
LLLKFLPTGISSKES	ZZEF1	1426	O43149
KLLLAAKSLSVDPGA	TLN2	1316	Q9Y4G6
TKLLVSGAASTPDKL	TLN2	2031	Q9Y4G6
VSLGLSFTKPKVISL	ZNF354B	51	Q96LW1
GKLTLPEKSLSEVLS	ZSCAN29	626	Q8IWY8
FLLLTKGADPRAISL	TRANK1	481	O15050
KLLLASEGRLKPSAS	UHRF1BP1	741	Q6BDS2
LVLIFAGKILKDPDS	UBQLN3	61	Q9H347
THLGFSLKDLSKLPL	TSHZ1	991	Q6ZSZ6
KLSAKEFGLLKPTSA	ZNF638	1431	Q14966
GKFSTLSLLLGYLKL	TTI1	396	O43156
LLTRAAKGFLSKPLI	VWA5B1	1021	Q5TIE3
PLDLKALKSTLGFPL	VPS13D	4006	Q5THJ4
LSVLSPKIGNLLFLS	LRRC8C	741	Q8TDW0
LQTLPKDIFKGLDSL	LGI1	151	O95970