Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	PDGFB NOXA1 NOXO1	2.40e-05	10	119	3	GO:0016176
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKM	1.05e-04	3	119	2	GO:0003872
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKM	3.48e-04	5	119	2	GO:0070095
GeneOntologyMolecularFunction	fructose binding	PFKL PFKM	5.20e-04	6	119	2	GO:0070061
GeneOntologyMolecularFunction	creatine kinase activity	CKMT2 CKMT1A	5.20e-04	6	119	2	GO:0004111
GeneOntologyMolecularFunction	kinase activity	CDK16 SPEG PFKL PFKM PEAK3 CKMT2 LRGUK LIMK2 DGKK TJP2 UCK2 WNK4 CKMT1A	6.36e-04	764	119	13	GO:0016301
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKM	7.25e-04	7	119	2	GO:0008443
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKM	9.93e-05	3	121	2	GO:0005945
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKM	1.14e-04	3	116	2	PS00433
Domain	6-Pfructokinase_euk	PFKL PFKM	1.14e-04	3	116	2	IPR009161
Domain	Phosphofructokinase_CS	PFKL PFKM	1.14e-04	3	116	2	IPR015912
Domain	PFK	PFKL PFKM	1.14e-04	3	116	2	PF00365
Domain	ATP_PFK	PFKL PFKM	1.14e-04	3	116	2	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKM	1.14e-04	3	116	2	IPR000023
Domain	PH	AGAP5 ARHGAP9 AGAP11 RTKN ARHGEF40 DGKK ARHGEF2 ARHGEF26	3.46e-04	278	116	8	SM00233
Domain	PH_DOMAIN	AGAP5 ARHGAP9 AGAP11 RTKN ARHGEF40 DGKK ARHGEF2 ARHGEF26	3.54e-04	279	116	8	PS50003
Domain	PH_domain	AGAP5 ARHGAP9 AGAP11 RTKN ARHGEF40 DGKK ARHGEF2 ARHGEF26	3.63e-04	280	116	8	IPR001849
Domain	tRNA_SAD	TARS2 AARS2	7.87e-04	7	116	2	SM00863
Domain	tRNA_SAD	TARS2 AARS2	7.87e-04	7	116	2	IPR012947
Domain	tRNA_SAD	TARS2 AARS2	7.87e-04	7	116	2	PF07973
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	HTRA2 ACAT1 PDHA2 ACAD9 STARD7 TARS2 LAP3 CKMT2 AARS2 CKMT1A	1.22e-06	382	124	10	29222160
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CDK16 TBKBP1 DOCK8 FRYL RTKN CEP170 UBR5 TJP2 LZTS2 ARHGEF2	4.83e-06	446	124	10	24255178
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A TBKBP1 LRRC24 SPEG SREBF1 THAP8 PER1 FRYL ARHGEF40 KANK3 DISP2 RIPOR1 ARHGEF2 TNPO3 ABCC10	9.74e-06	1105	124	15	35748872
Pubmed	Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.	PFKL PFKM	1.26e-05	2	124	2	29655163
Pubmed	C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population.	C2CD4B C2CD4A	1.26e-05	2	124	2	35212842
Pubmed	Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.	C2CD4B C2CD4A	1.26e-05	2	124	2	33492421
Pubmed	A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.	C2CD4B C2CD4A	1.26e-05	2	124	2	29625024
Pubmed	The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms".	NOXA1 NOXO1	1.26e-05	2	124	2	17189823
Pubmed	Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.	PFKL PFKM	1.26e-05	2	124	2	8780720
Pubmed	The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy.	PFKL PFKM	1.26e-05	2	124	2	6444532
Pubmed	C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.	NOXA1 NOXO1	1.26e-05	2	124	2	28625920
Pubmed	The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B.	SAFB TJP2	1.26e-05	2	124	2	12403786
Pubmed	Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B.	HTRA2 RTKN	1.26e-05	2	124	2	9073523
Pubmed	The glycolytic enzyme phosphofructokinase-1 assembles into filaments.	PFKL PFKM	1.26e-05	2	124	2	28646105
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	MARS2 HTRA2 ACAT1 PDHA2 ACAD9 STARD7 TARS2 LAP3 STAR CKMT2 NLN AARS2 TIMM50 C8orf82 CKMT1A	1.35e-05	1136	124	15	34800366
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DMXL2 LZTS3 ACAT1 DOCK8 PFKL PFKM CEP170 CORO1A SAFB TTC7B GUCY1A2 HNRNPUL2 SYNGR3 TJP2 ARHGEF2 CROCC CKMT1A	1.36e-05	1431	124	17	37142655
Pubmed	Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.	MARS2 TARS2 AARS2	1.56e-05	14	124	3	15779907
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	ACAD9 PFKM TARS2 LAP3 RIOX2 CEP170 AARS2 UBR5 TIMM50 UCK2	2.29e-05	534	124	10	35032548
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	MARS2 HTRA2 ACAT1 PDHA2 ACAD9 TARS2 LAP3 STAR CKMT2 NLN AARS2 TIMM50 C8orf82 CKMT1A	2.32e-05	1047	124	14	18614015
Pubmed	Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation.	NOXA1 NOXO1	3.77e-05	3	124	2	35031518
Pubmed	Creatine kinase and creatine transporter in normal, wounded, and diseased skin.	CKMT2 CKMT1A	3.77e-05	3	124	2	11874479
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKM	3.77e-05	3	124	2	33141153
Pubmed	A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.	C2CD4B C2CD4A	3.77e-05	3	124	2	20818381
Pubmed	A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.	C2CD4B C2CD4A	3.77e-05	3	124	2	21799836
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKM	3.77e-05	3	124	2	156693
Pubmed	Two novel proteins activate superoxide generation by the NADPH oxidase NOX1.	NOXA1 NOXO1	3.77e-05	3	124	2	12473664
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKM	3.77e-05	3	124	2	7825568
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKM	3.77e-05	3	124	2	6451249
Pubmed	Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues.	CKMT2 CKMT1A	3.77e-05	3	124	2	12401781
Pubmed	Maintained coupling of oxidative phosphorylation to creatine kinase activity in sarcomeric mitochondrial creatine kinase-deficient mice.	CKMT2 CKMT1A	3.77e-05	3	124	2	9618231
Pubmed	Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.	C2CD4B C2CD4A	3.77e-05	3	124	2	27329800
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKM	3.77e-05	3	124	2	6444721
Pubmed	Molecular characterization of the creatine kinases and some historical perspectives.	CKMT2 CKMT1A	3.77e-05	3	124	2	9746319
Pubmed	Expression of the mitochondrial creatine kinase genes.	CKMT2 CKMT1A	3.77e-05	3	124	2	7808456
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKM	3.77e-05	3	124	2	11137296
Pubmed	Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase.	CKMT2 CKMT1A	3.77e-05	3	124	2	9125373
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKM	3.77e-05	3	124	2	2960695
Pubmed	Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding.	CKMT2 CKMT1A	3.77e-05	3	124	2	10748055
Pubmed	NoxO1 regulates EGFR signaling by its interaction with Erbin.	NOXA1 NOXO1	3.77e-05	3	124	2	39426288
Pubmed	Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes.	CKMT2 CKMT1A	3.77e-05	3	124	2	2324105
Pubmed	A novel gene family induced by acute inflammation in endothelial cells.	C2CD4B C2CD4A	3.77e-05	3	124	2	15527968
Pubmed	Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.	CKMT2 CKMT1A	3.77e-05	3	124	2	18948110
Pubmed	A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance.	CKMT2 CKMT1A	3.77e-05	3	124	2	11768757
Pubmed	Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1).	NOXA1 NOXO1	3.77e-05	3	124	2	17126813
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKM	3.77e-05	3	124	2	2521854
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF219 PHRF1 PER1 CEP170 MALT1 LIMK2 ARHGEF40 HMCN2 UBR5 SUPT16H TIMM50 UCK2 CHPF2 LZTS2	4.64e-05	1116	124	14	31753913
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	ACAT1 PFKL TARS2 LAP3 CORO1A AARS2 HNRNPUL2 SUPT16H TIMM50 CKMT1A	6.70e-05	607	124	10	39147351
Pubmed	Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1.	NOXA1 NOXO1	7.53e-05	4	124	2	16329988
Pubmed	The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1.	RTKN ARHGEF2	7.53e-05	4	124	2	24525234
Pubmed	Altered rhythm of adrenal clock genes, StAR and serum corticosterone in VIP receptor 2-deficient mice.	PER1 STAR	7.53e-05	4	124	2	22622901
Pubmed	SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.	SREBF1 SAFB	7.53e-05	4	124	2	19403048
Pubmed	Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells.	NOXA1 NOXO1	7.53e-05	4	124	2	12657628
Pubmed	Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.	NOXA1 NOXO1	7.53e-05	4	124	2	23957209
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ACAT1 PFKL CEP170 SAFB AARS2 UBR5 HNRNPUL2 SUPT16H TIMM50 TJP2 UCK2 ARHGEF2 KIFC1	7.80e-05	1024	124	13	24711643
Pubmed	Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.	MARS2 ACAT1 ACAD9 TARS2 AARS2 C8orf82	1.03e-04	207	124	6	31056398
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	MARS2 HTRA2 ACAT1 PDHA2 ACAD9 TARS2 LAP3 STAR CKMT2 NLN AARS2 CKMT1A	1.23e-04	926	124	12	20877624
Pubmed	Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.	CKMT2 CKMT1A	1.25e-04	5	124	2	24587121
Pubmed	Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.	CKMT2 CKMT1A	1.25e-04	5	124	2	2914937
Pubmed	Analysis of pyruvate dehydrogenase expression in embryonic mouse brain: localization and developmental regulation.	ACAT1 PDHA2	1.25e-04	5	124	2	7510589
Pubmed	Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.	NOXA1 NOXO1	1.25e-04	5	124	2	19755710
Pubmed	Nox1-dependent reactive oxygen generation is regulated by Rac1.	NOXA1 NOXO1	1.25e-04	5	124	2	16636067
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	PFKL PFKM TARS2 TIMM50 UCK2 ARHGEF2 TNPO3	1.66e-04	323	124	7	24797263
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PFKL TARS2 UBR5	1.67e-04	30	124	3	32867711
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MARS2 HTRA2 ACAT1 ACAD9 PFKL PFKM TARS2 LAP3 RIOX2 SAFB HNRNPUL2 SUPT16H TIMM50 KIFC1 CKMT1A	1.73e-04	1425	124	15	30948266
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MARS2 PDHA2 ACAD9 TARS2 RIOX2 CKMT2 NLN AARS2 TNPO3 CKMT1A	1.81e-04	686	124	10	28380382
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	DMXL2 FRYL UBR5 TJP2 USP27X	1.89e-04	147	124	5	29576527
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	PFKL CEP170 AARS2 UBR5 TJP2	2.50e-04	156	124	5	29961565
Pubmed	Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.	NOXA1 NOXO1	2.62e-04	7	124	2	20454568
Pubmed	Creatine and creatinine metabolism.	CKMT2 CKMT1A	2.62e-04	7	124	2	10893433
Pubmed	Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.	TOPBP1 UBR5	2.62e-04	7	124	2	11714696
Pubmed	Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.	NOXA1 NOXO1	2.62e-04	7	124	2	12716910
Pubmed	The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology.	RTKN ARHGEF2	2.62e-04	7	124	2	15996550
Pubmed	Genomic analysis of mouse retinal development.	RPGRIP1 ZNF219 TAPT1 PHRF1 STARD7 FRYL LIMK2 TTC7B NKD1 HNRNPUL2 SUPT16H CROCC	2.63e-04	1006	124	12	15226823
Pubmed	Functional proteomics mapping of a human signaling pathway.	DOCK8 SNX17 ARHGAP9 PFKL LIMK2 UBR5 LZTS2 TNPO3 SMAD6	2.80e-04	591	124	9	15231748
Pubmed	Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.	MARCHF2 KANK3 KIFC1	2.90e-04	36	124	3	15112104
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	KIF12 SLC22A6 PKHD1	2.90e-04	36	124	3	33737325
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	HTRA2 LAP3 UBR5 HNRNPUL2 TIMM50 UCK2	3.05e-04	253	124	6	29911972
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	ACAT1 PFKM LAP3 CORO1A HNRNPUL2	3.32e-04	166	124	5	27160897
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	SNX17 UBR5 SUPT16H TIMM50 ARHGEF2	3.42e-04	167	124	5	25659891
Pubmed	Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.	TOPBP1 UBR5	3.48e-04	8	124	2	35768646
Pubmed	A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.	CEP170 CROCC	3.48e-04	8	124	2	27623382
Pubmed	CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.	TOPBP1 UBR5	3.48e-04	8	124	2	34145035
Pubmed	Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.	HTRA2 TIMM50	3.48e-04	8	124	2	15044455
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP11	4.47e-04	9	124	2	12640130
Pubmed	The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.	UBR5 SUPT16H	4.47e-04	9	124	2	30508113
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	PFKL PFKM	4.47e-04	9	124	2	21074528
Pubmed	Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.	SNX17 ADAMTS13 TTC7B WNK4	4.63e-04	100	124	4	26073538
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	SETD1A UBR5 ARHGEF2	4.92e-04	43	124	3	33472061
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DMXL2 SREBF1 PFKL TARS2 ARHGEF40 HNRNPUL2 CHPF2 ARHGEF2 KIFC1	5.56e-04	650	124	9	38777146
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP11	5.57e-04	10	124	2	20664521
Pubmed	High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.	HTRA2 RTKN	5.57e-04	10	124	2	9806835
Pubmed	Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.	TTC7B GUCY1A2	5.57e-04	10	124	2	25390645
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DOCK8 TOGARAM2 PFKL PFKM CCDC7 CEP170 CORO1A SAFB UBR5 ARHGEF2 TNPO3 KIFC1	5.98e-04	1103	124	12	34189442
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	SLC22A6 CCDC198 WNK4	6.40e-04	47	124	3	15172686
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP11	6.79e-04	11	124	2	15381706
Pubmed	Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.	PHRF1 TNPO3	6.79e-04	11	124	2	18204446
Pubmed	The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.	LZTS3 LZTS2	6.79e-04	11	124	2	21949185
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	SETD1A KIFC1	6.79e-04	11	124	2	18082152
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 ZNF219 LZTS3 LRRC24 HCN3 CEP170 UBR5 HNRNPUL2 SUPT16H ARHGEF2 ARHGEF26	6.83e-04	963	124	11	28671696
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 AGAP11 FNDC10 UBR5	8.10e-04	116	124	4	30652415
GeneFamily	Leucine zipper tumor suppressor family	LZTS3 LZTS2	9.34e-05	4	72	2	1314
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1 C2CD4B C2CD4A	3.93e-04	36	72	3	823
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 ARHGAP9 RTKN ARHGEF2 ARHGEF26	1.38e-03	206	72	5	682
GeneFamily	StAR related lipid transfer domain containing	STARD7 STAR	1.59e-03	15	72	2	759
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP11	2.05e-03	17	72	2	1291
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF40 ARHGEF2 ARHGEF26	2.32e-03	66	72	3	722
GeneFamily	Aminoacyl tRNA synthetases, Class II	TARS2 AARS2	2.56e-03	19	72	2	132
GeneFamily	PDZ domain containing	HTRA2 LIMK2 GRID2IP TJP2	3.17e-03	152	72	4	1220
CoexpressionAtlas	DevelopingKidney_e11.5_ureteric bud_emap-3844_k-means-cluster#2_top-relative-expression-ranked_200	KIF12 FHOD3 CCDC198 PKHD1	8.26e-06	24	116	4	gudmap_developingKidney_e11.5_ureteric bud_200_k2
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#1_top-relative-expression-ranked_100	KIF12 CCDC198 PKHD1	1.30e-05	9	116	3	gudmap_developingKidney_e15.5_Medullary collecting duct_100_k1
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	NOXA1 KIF12 TEX22 KANK3 SCNN1D CROCC	4.85e-06	155	124	6	a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCell	droplet-Fat-Mat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOXA1 KIF12 CCDC198 GRID2IP PKHD1 CKMT1A	5.03e-06	156	124	6	cfd7f56f3155db677684827607e9008e975dbe70
ToppCell	droplet-Fat-Mat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOXA1 KIF12 CCDC198 GRID2IP PKHD1 CKMT1A	5.03e-06	156	124	6	0d79b4172896574b00faf00e87254f68d76f5512
ToppCell	droplet-Fat-Mat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOXA1 KIF12 CCDC198 GRID2IP PKHD1 CKMT1A	5.03e-06	156	124	6	f09150aacb6121f913648ed3918f9cd4f22c61f2
ToppCell	VE-CD8-naive_CD4\|VE / Condition, Cell_class and T cell subcluster	SETD1A AGAP5 C2CD4B PELI3 USP27X TNPO3	5.82e-06	160	124	6	255d2a150bfe19ee3d4d34533feb9c37ce73d225
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	THAP8 SLC22A6 CCDC198 PKHD1 WNK4	6.97e-06	95	124	5	3699ea16660a22ea79fecfea56ece2dfb0f13467
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	THAP8 SLC22A6 CCDC198 PKHD1 WNK4	6.97e-06	95	124	5	cbfe615d880913bafaf5e7e8d24c3ec14a9351ce
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	THAP8 SLC22A6 CCDC198 PKHD1 WNK4	6.97e-06	95	124	5	27ac23b87747434a3084cc087e7b884e68f0eab9
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1\|TCGA-Uvea / Sample_Type by Project: Shred V9	TRARG1 MARCHF2 PELI3 PFKL HNRNPUL2 KANK3	7.69e-06	168	124	6	b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	MARS2 HTRA2 TARS2 FNDC10 AARS2 DISP2	8.80e-06	172	124	6	9dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 MARCHF2 TOGARAM2 ARHGAP9 MPIG6B CORO1A	1.37e-05	186	124	6	ed265e52e4f9b6d277b489091ecc2e629436f791
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	HCN3 FHOD3 GFRA4 SYNGR3 DISP2 CKMT1A	1.41e-05	187	124	6	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ZNF219 TARS2 TMEM132C LIMK2 NKD1 SMAD6	1.46e-05	188	124	6	8231e635706a296db6b6da1029a33bbc1b52478e
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRARG1 AGAP11 VWA7 STAR PKHD1 ITIH6	1.69e-05	193	124	6	315840bc48899f3a36d57b19197509de19716e3d
Disease	disease of metabolism (implicated_via_orthology)	PDHA2 PFKL PFKM	8.27e-05	21	120	3	DOID:0014667 (implicated_via_orthology)
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKM	9.79e-05	4	120	2	DOID:2747 (implicated_via_orthology)
Disease	disease of metabolism (is_implicated_in)	SREBF1 TJP2	2.43e-04	6	120	2	DOID:0014667 (is_implicated_in)
Disease	3-Methylglutaconic aciduria	HTRA2 TIMM50	4.52e-04	8	120	2	cv:C3696376
Disease	Combined oxidative phosphorylation deficiency	MARS2 TARS2 AARS2	4.61e-04	37	120	3	cv:C4540031
Disease	Combined immunodeficiency	DOCK8 MALT1 CORO1A	6.25e-04	41	120	3	C0494261
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP11	7.23e-04	10	120	2	DOID:1969 (implicated_via_orthology)
Disease	quality of life during menstruation measurement, acne	FHOD3 NLN	8.81e-04	11	120	2	EFO_0003894, EFO_0009366
Disease	triacylglycerol 50:5 measurement	SNX17 LRTM2	1.90e-03	16	120	2	EFO_0010412
Disease	hematocrit	TRARG1 PELI3 SREBF1 PFKL PFKM ARHGEF40 ABHD16B DGKK PKHD1 CROCC SMAD6	2.82e-03	1011	120	11	EFO_0004348
Disease	red blood cell density measurement	ZNF219 PDGFB PFKM ARHGEF40 ABHD16B UBR5 PKHD1 TJP2 CROCC SMAD6	3.21e-03	880	120	10	EFO_0007978
Disease	resting heart rate	SPEG SREBF1 FHOD3 ARHGEF40	3.26e-03	149	120	4	EFO_0004351
Disease	triacylglycerol 48:3 measurement	SNX17 LRTM2	3.59e-03	22	120	2	EFO_0010406

Protein segments in the cluster

Peptide	Gene	Start	Entry
ATSLASQGERRRRTL	CEP170	631	Q5SW79
SRALQLRGEELSRRL	CCDC17	156	Q96LX7
LSRTGRASIQRDLRE	CEACAM4	176	O75871
RSLGTRLSRVRSLEL	AGAP11	371	Q8TF27
TLSALLTGRAARTRA	ARHGEF40	1406	Q8TER5
GTLRTLALARSRGAR	C8orf82	6	Q6P1X6
TDIESLRGALGRRLL	CCDC7	1006	Q96M83
LLLLLHTDRSTTRRG	CDCP2	351	Q5VXM1
RQSLLGSRRGRSSLS	ARHGEF2	131	Q92974
TVGRRLRDSLGRTVD	ACAD9	466	Q9H845
VLSRASRSIRIGLRN	ACAD9	546	Q9H845
RRLGLLGRTLEASAS	CLDN25	116	C9JDP6
GSLRRGLRSTSYRRA	ARHGEF26	306	Q96DR7
SRELRVNRGLDTGRR	CORO1A	401	P31146
QGLLLSDRRRLRTES	DMXL2	2291	Q8TDJ6
LRGLRRAAAGTSRLL	DISP2	676	A7MBM2
SRRQLLSLLSAGRAR	ADAMTS13	266	Q76LX8
VGQGLSSRRRRRLAL	ABHD16B	426	Q9H3Z7
LVRSFRRLGLRLDRT	ANKRD63	136	C9JTQ0
RQLRLAGTIGRSTRE	NKD1	51	Q969G9
LRARRGADLSSLRAL	NOXA1	326	Q86UR1
RLAVRRFGSRSLSTA	LAP3	16	P28838
RASSRELRRLGSLTL	ABCC10	1086	Q5T3U5
RRRSRRGTLSSISSL	DGKK	816	Q5KSL6
ARATLRVSEGRARGL	LZTS2	481	Q9BRK4
VGLRSQLREGRASLR	LZTS3	471	O60299
RSSGSRTLLLLHRAL	GLTPD2	176	A6NH11
TSRDGRLLSTVIRAL	MARCHF2	41	Q9P0N8
RLAELAGSRGRLRLS	MALT1	56	Q9UDY8
GTERSRLRERTATLE	FAM149A	696	A5PLN7
RSALLSSGRLLRRLG	GPR179	481	Q6PRD1
EGTLRRRSLRRSNSI	LIMK2	276	P53671
IDGASRILERSLSRR	HMCN2	56	Q8NDA2
RLEALRDQIGSSLRR	KIF12	611	Q96FN5
RITLVASALRRRASG	EZHIP	216	Q86X51
DGLLSRALRAGRSRR	C2CD4B	181	A6NLJ0
TRLSLSRSDERRGTL	KIFC1	346	Q9BW19
SRFRDLGRLRGLDSS	PER1	796	O15534
LARGRRSLGSLTIAE	PDGFB	76	P01127
RLGETRSRGSRLNII	PFKL	246	P17858
RLSETRTRGSRLNII	PFKM	246	P08237
AGRLRRRRSAATFLL	PTGER1	61	P34995
LTRLRPSASRTRGAL	PEAK3	381	Q6ZS72
SLRLSLIGDRRGDRR	FRYL	1941	O94915
LIGDRRGDRRRSNTL	FRYL	1946	O94915
LRSELQRRGLDSRGL	HNRNPUL2	11	Q1KMD3
EATTRSRIARTLGLR	PHRF1	386	Q9P1Y6
LELALTSNRLRGLRS	LRRC24	101	Q50LG9
DRSRRRLRVADLTGI	LRRC14B	101	A6NHZ5
RALLRTRAASLLRGL	LRGUK	6	Q96M69
TRAASLLRGLGRSRT	LRGUK	11	Q96M69
LRTGEVRTARTLGDR	PCDHGB3	621	Q9Y5G1
GLLSVLARGARDTRL	HCN3	471	Q9P1Z3
LLTRGRRTASVRADT	HCN3	496	Q9P1Z3
LRLRRAESTRRVLGL	ERCC8	16	Q13216
RLDLAAVTLRRGLRS	FAM189A2	301	Q15884
SSSLRRLLSGRRLER	FAM189B	636	P81408
RRSSSLRVSRNALLG	GALR1	141	P47211
EGEFRTRERRLLGSL	CROCC	1356	Q5TZA2
TRERRLLGSLEEARG	CROCC	1361	Q5TZA2
ADRRRVRVRLLSGDT	HTRA2	201	O43464
AVGGLSRERLVRLAR	GRID2IP	56	A4D2P6
RLSRELGGRVDRLLR	BORCS6	266	Q96GS4
RRLRTSRSTEILGED	DOCK8-AS1	41	Q5T8R8
SSVGERRTLAQSRRL	DOCK8	431	Q8NF50
STGRALERRSLLSIL	GFRA4	276	Q9GZZ7
SRRLRRVSLSEIGFG	CDK16	146	Q00536
GRSLRASVLRNRSVL	FNDC10	76	F2Z333
ARTGSRIVIGISRER	ERCC6L2-AS1	106	Q8WZB0
RSVSRGRADLSLDLT	FHOD3	501	Q2V2M9
LTAVALARLATRTRR	GPR142	176	Q7Z601
TLLRRLSLENRGIAR	ITIH6	436	Q6UXX5
RSSISLRGEGTLRLS	ITIH6	1161	Q6UXX5
QLRRLTERLATSERG	KANK3	246	Q6NY19
ADRERILSLRTGRGR	KLHDC7B	266	Q96G42
RVITSGRLLSQREAR	CCDC198	111	Q9NVL8
DASALTLVLGGRRLR	SCNN1D	716	P51172
SSSGRLDLTLRALQR	SLC22A6	276	Q4U2R8
DGLLSRALRAGRSRR	C2CD4A	186	Q8NCU7
SSRVRTGRSIRGLSL	CKMT1A	161	P12532
LSSRVRTGRSIRGLS	CKMT2	161	P17540
LRVLEATARAGGRIR	PAOX	41	Q6QHF9
GLSVRSILAELTGRR	PDHA2	126	P29803
RRRRVNLDSLGESIS	GUCY1A2	81	P33402
LGRSSGRRVRASLDS	RTKN	221	Q9BST9
DADSGLTLSRRIRRA	TARS2	646	Q9BW92
ESLLARARRGLQRLT	THAP8	211	Q8NA92
TTLLRLTAAGRDLRV	RPGRIP1	76	Q96KN7
GRSREARSRLLLLEQ	SMAD6	156	O43541
GASRSRRSLSLNRLL	SPATA5L1	86	Q9BVQ7
GALRRATTTARSLLD	TMEM132C	851	Q8N3T6
RRLSEGLAASSRASL	TOGARAM2	131	Q6ZUX3
DGLLALRSLSLRSNR	LRTM2	161	Q8N967
ASGDKGRRRSRLALS	PELI3	81	Q8N2H9
VGRLRSLDSGIRRLE	MPIG6B	81	O95866
ALLRSGARSRSPLLR	ACAT1	6	P24752
ILTVRGLLLNSRRRS	PKHD1	1406	P08F94
GLLLNSRRRSVRVDL	PKHD1	1411	P08F94
LRSDSGSDLLRRTER	SPATA31C1	561	P0DKV0
LGRGSRAALLTERTR	SUPT16H	451	Q9Y5B9
RVGRTSRGLARLQLL	NOXO1	86	Q8NFA2
RRSEQRRLLSAIGTS	SETD1A	1536	O15047
SLERGRRIIDRTLRT	AARS2	411	Q5JTZ9
TGTRRLSDLRVIDLR	SAFB	26	Q15424
LRGFQRDLSSLRRLA	SREBF1	1011	P36956
HRSLGTRLSRVRSLE	AGAP5	506	A6NIR3
LGSRERLLVAVLTSR	CHPF2	96	Q9P2E5
LLAVRSLRRVGGSRI	NLN	6	Q9BYT8
LRRRVGGTLRRSDSQ	SNX17	396	Q15036
VSIDERRRLATLGGR	TEX22	66	C9J3V5
RRRITSSFTIGLRGL	USP27X	66	A6NNY8
AVFSRLRSGLRLGSR	TIMM50	6	Q3ZCQ8
LSRDRSRGRSLERGL	TJP2	191	Q9UDY2
SLGLRLLSRSRSEER	SPEG	2346	Q15772
LRRATSEGESLRRLG	SPEG	2491	Q15772
QVRRRSSLLGSRLEE	STAR	51	P49675
LLRLSSRRSSIRGPE	ARHGAP9	491	Q9BRR9
ARDTRRLGATILDRI	RRAGB	66	Q5VZM2
SSVRDRRRAVLLDLG	SYNGR3	96	O43761
TRLSRRVLRDISERG	UCK2	161	Q9BZX2
VLRLLGRTGASRLSL	MARS2	6	Q96GW9
RRLSGFLRTLADRLE	RIOX2	306	Q8IUF8
SRSLRIGANRRTEII	TNPO3	156	Q9Y5L0
GRGSSLLDRTIADRR	TTC7B	626	Q86TV6
SLGSSEGRRSVRLIL	SLC46A2	161	Q9BY10
GRLYSESSRRVLLGR	STARD7	46	Q9NQZ5
RRRGRTELSLLRFLS	TAPT1	61	Q6NXT6
GARRLGRLARLLSIT	TRARG1	141	Q8IXB3
EGRLRRDGLRALSSL	RIPOR1	1091	Q6ZS17
GRLRELSSLQGRILR	TBKBP1	306	A7MCY6
RSRLGDRDFSRLLDI	VWA7	296	Q9Y334
SARSGRSRVLEALRQ	TOPBP1	1111	Q92547
SSRLSRRSSVDLGLL	WNK4	56	Q96J92
RALLREARLGRARSS	ZNF219	126	Q9P2Y4
SLRTLEGRRRATLLS	UBR5	1891	O95071