Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of autophagy

LEPR PIK3CA ZKSCAN3 TNFAIP3 HERC1 TP53

1.40e-05112966GO:0010507
MousePhenoabnormal cell differentiation

TET2 NRIP1 PDE3A TCHP SRRM4 ZP2 CREB3L1 LEPR MAPK8IP3 ABCG1 NEIL3 PADI6 ZNF281 DYNC1H1 TP53 WDR62

1.47e-057958316MP:0005076
MousePhenoinfertility

ADAD1 NRIP1 PRAMEF33 PDE3A SPEM2 PRAMEF10 FAM209A PI4K2A ZP2 LEPR LRP8 FAM209B MAEL PADI6 HERC1 DYNC1H1 PCM1 WDR62 FOXI1

5.22e-0511888319MP:0001924
MousePhenoincreased enterocyte apoptosis

NRIP1 LEPR TP53

5.53e-0513833MP:0008885
MousePhenodecreased neuronal precursor cell number

SRRM4 NEIL3 TP53 WDR62

6.57e-0537834MP:0004981
MousePhenoabnormal neuron number

LRRN1 SRRM4 PI4K2A LEPR LRP8 OTX2 NEIL3 HERC1 DYNC1H1 TP53 WDR62

7.66e-054568311MP:0008946
DomainFAM209

FAM209A FAM209B

2.73e-052982IPR027943
DomainFAM209

FAM209A FAM209B

2.73e-052982PF15206
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 DOCK11 SIPA1L3 TTK STARD9 KIAA1217 SSX2IP TNFAIP3 ARHGEF2 PCM1 TP53 WDR62 ZC3HAV1

1.32e-068611011336931259
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PRUNE2 NRIP1 LRRN1 TCHP SOBP SIPA1L3 CHST11 CERT1 MAPK8IP3 LRP8 ABCG1 ZNF33B KIAA1217 EHMT1 MAST1 PCM1 ZC3HAV1

1.32e-0614891011728611215
Pubmed

TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers.

TTK TP53

8.35e-062101224462521
Pubmed

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.

OTX2 TP53

8.35e-062101236181537
Pubmed

Clinical implications of genomic profiles in metastatic breast cancer with a focus on TP53 and PIK3CA, the most frequently mutated genes.

PIK3CA TP53

8.35e-062101228427202
Pubmed

High rate of PIK3CA mutations but no TP53 mutations in low-grade adenosquamous carcinoma of the breast.

PIK3CA TP53

8.35e-062101229537649
Pubmed

Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells.

TNFAIP3 TP53

8.35e-062101224099634
Pubmed

A Comprehensive Survey of Genomic Alterations in Gastric Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

PIK3CA TP53

8.35e-062101231781598
Pubmed

p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

TET2 TP53

8.35e-062101230390073
Pubmed

TP53 and PIK3CA gene mutations in adenocarcinoma, squamous cell carcinoma and high-grade intraepithelial neoplasia of the cervix.

PIK3CA TP53

8.35e-062101225220666
Pubmed

Prognostic role of PIK3CA and TP53 in human papillomavirus-negative oropharyngeal cancers.

PIK3CA TP53

8.35e-062101229714670
Pubmed

An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer.

PIK3CA TP53

8.35e-062101236563059
Pubmed

Discordance of PIK3CA and TP53 mutations between breast cancer brain metastases and matched primary tumors.

PIK3CA TP53

8.35e-062101234876602
Pubmed

Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation.

SSX2IP PCM1

8.35e-062101224397932
Pubmed

Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer.

PIK3CA TP53

8.35e-062101237344660
Pubmed

The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma.

PIK3CA TP53

8.35e-062101233290961
Pubmed

PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients.

PIK3CA TP53

8.35e-062101229434452
Pubmed

Effects of TP53 and PIK3CA mutations in early breast cancer: a matter of co-mutation and tumor-infiltrating lymphocytes.

PIK3CA TP53

8.35e-062101227369359
Pubmed

Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.

LEPR PIK3CA

8.35e-062101225589743
Pubmed

Clinical significance of joint detection of CD44v6 and CD62P in nasopharyngeal carcinoma.

SELP TP53

8.35e-062101224192766
Pubmed

The deubiquitinating enzyme USP24 is a regulator of the UV damage response.

USP24 TP53

8.35e-062101225578727
Pubmed

PIK3CA and TP53 gene mutations in human breast cancer tumors frequently detected by ion torrent DNA sequencing.

PIK3CA TP53

8.35e-062101224918944
Pubmed

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.

PIK3CA TP53

8.35e-062101218270270
Pubmed

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53.

VCAN TP53

8.35e-062101212438652
Pubmed

Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice.

LEPR ABCG1

8.35e-062101222179025
Pubmed

Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity.

OTX2 TP53

8.35e-062101223770240
Pubmed

Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells.

ARHGEF2 TP53

8.35e-062101216778209
Pubmed

Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint.

ZBTB17 TP53

8.35e-062101221841135
Pubmed

Bladder polypoid cystitis-derived A20 associates with tumorigenesis.

TNFAIP3 TP53

8.35e-062101223471665
Pubmed

Comparison of mutational profiles between triple-negative and hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancers in T2N0-1M0 stage: Implications of TP53 and PIK3CA mutations in Korean early-stage breast cancers.

PIK3CA TP53

8.35e-062101235180531
Pubmed

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

TTK TP53

8.35e-062101225197064
Pubmed

Lack of association of TNFAIP3 and JAK1 with Behçet's disease in the European population.

JAK1 TNFAIP3

8.35e-062101226005883
Pubmed

Mutation in TET2 or TP53 predicts poor survival in patients with myelodysplastic syndrome receiving hypomethylating treatment or stem cell transplantation.

TET2 TP53

8.35e-062101225961778
Pubmed

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: "it's a numbers game"-implications for WNT medulloblastoma dose-reduction clinical trials.

OTX2 TP53

8.35e-062101236403175
Pubmed

A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast cancer.

PIK3CA TP53

8.35e-062101224908061
Pubmed

PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity.

PIK3CA TP53

8.35e-062101228190247
Pubmed

S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.

PIK3CA TP53

8.35e-062101231881983
Pubmed

Co-mutation of TP53 and PIK3CA in residual disease after neoadjuvant chemotherapy is associated with poor survival in breast cancer.

PIK3CA TP53

8.35e-062101230806788
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TET2 NRIP1 SIPA1L3 ADGRB3 NCKAP5 EYA3 ZBED5 MAPK8IP3 JAK1 ZBTB44 NAV3 MAST1 DYNC1H1 PCM1

2.11e-0512851011435914814
Pubmed

Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.

SELP CHST11

2.50e-053101221658254
Pubmed

Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

PIK3CA TP53

2.50e-053101222923510
Pubmed

Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.

PIK3CA TP53

2.50e-053101223702729
Pubmed

TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.

TTK TP53

2.50e-053101219332559
Pubmed

Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes.

PIK3CA TP53

2.50e-053101228285689
Pubmed

A20 regulates canonical wnt-signaling through an interaction with RIPK4.

TNFAIP3 TP53

2.50e-053101229718933
Pubmed

Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.

PIK3CA TP53

2.50e-053101227070496
Pubmed

Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.

PIK3CA TP53

2.50e-053101219234438
Pubmed

PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice.

PIK3CA TP53

2.50e-053101232152233
Pubmed

Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects.

LEPR PIK3CA

2.50e-053101223541372
Pubmed

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes.

LEPR TP53

2.50e-053101224516131
Pubmed

Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease.

PIK3CA TP53

2.50e-053101234849446
Pubmed

A microscopic landscape of the invasive breast cancer genome.

PIK3CA TP53

2.50e-053101227283966
Pubmed

RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.

NRIP1 ABCG1

2.50e-053101225616132
Pubmed

A new genetically engineered mouse model of choroid plexus carcinoma.

OTX2 TP53

2.50e-053101229339161
Pubmed

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.

PIK3CA TP53

2.50e-053101217060456
Pubmed

Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies.

LRP8 C5

2.50e-053101229716893
Pubmed

Survival prediction model for non-small cell lung cancer based on somatic mutations.

PIK3CA TP53

2.50e-053101232367667
Pubmed

Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.

PIK3CA TP53

2.50e-053101223384338
Pubmed

Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy.

PIK3CA TP53

2.50e-053101234421886
Pubmed

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

PIK3CA TP53

2.50e-053101227402769
Pubmed

DNA Methylation Profiles of Ovarian Clear Cell Carcinoma.

PIK3CA TP53

2.50e-053101234697060
Pubmed

Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation.

LEPR ABCG1

2.50e-053101216723355
Pubmed

The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.

SSX2IP PCM1

2.50e-053101224356449
Pubmed

Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.

PIK3CA TP53

2.50e-053101225695693
Pubmed

Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

TET2 ZNF281

2.50e-053101227345836
Pubmed

Predictive Role of TP53, PIK3CA and MLL2 in ER+ HER2+ Breast Bancer: Biomarker Analysis of Neo-ALL-IN [NCT 01275859].

PIK3CA TP53

2.50e-053101232988919
Pubmed

Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

LEPR TP53

2.50e-053101224332968
Pubmed

Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells.

PIK3CA TP53

2.50e-053101231711466
Pubmed

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner.

LEPR TP53

2.50e-053101227721459
Pubmed

Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections.

PIK3CA TP53

2.50e-053101223583669
Pubmed

Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway.

JAK1 PIK3CA

2.50e-053101221861134
Pubmed

Gene mutation detection of urinary sediment cells for NMIBC early diagnose and prediction of NMIBC relapse after surgery.

PIK3CA TP53

2.50e-053101231393349
Pubmed

Transforming growth factor-β-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy.

LEPR TP53

2.50e-053101223649518
Pubmed

RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53.

NRIP1 TP53

2.50e-053101235501580
Pubmed

ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation.

ZBTB17 TP53

2.50e-053101219901969
Pubmed

Expression of VEGF-A, Otx homeobox and p53 family genes in proliferative vitreoretinopathy.

OTX2 TP53

2.50e-053101224227910
Pubmed

Somatic mutation profiling of hobnail variant of papillary thyroid carcinoma.

PIK3CA TP53

2.50e-053101228062544
Pubmed

Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population.

C5 TNFAIP3

2.50e-053101219902201
Pubmed

Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study.

PIK3CA TP53

2.50e-053101238836758
Pubmed

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

PIK3CA TP53

2.50e-053101225452273
Pubmed

Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma.

PIK3CA TP53

2.50e-053101234397726
Pubmed

Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.

LEPR TP53

2.50e-053101219202066
Pubmed

Novel mutations target distinct subgroups of medulloblastoma.

PIK3CA TP53

2.50e-053101222722829
Pubmed

NGS-identified circulating miR-375 as a potential regulating component of myocardial infarction associated network.

PIK3CA TP53

2.50e-053101230025897
Pubmed

Combined mutational analysis of RAS, BRAF, PIK3CA, and TP53 genes in Taiwanese patients with oral squamous cell carcinoma.

PIK3CA TP53

2.50e-053101224908601
Pubmed

Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.

ZBTB17 TP53

2.50e-053101225468973
Pubmed

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.

ASH2L TP53

2.50e-053101225023704
Pubmed

Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.

EHMT1 DYNC1H1 WDR62

2.61e-0520101336551904
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

SIPA1L3 GPN1 TTK KIAA1217 SSX2IP ARHGEF2 DYNC1H1 PCM1 TP53 WDR62 ZC3HAV1

3.87e-058531011128718761
Pubmed

Resistance to UV-induced apoptosis by β-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase.

HERC1 TP53

4.99e-054101225408501
Pubmed

Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.

JAK1 TP53

4.99e-054101224413661
Pubmed

High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.

PIK3CA TP53

4.99e-054101223219661
Pubmed

Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2, TP53, and CBL mutations.

TET2 TP53

4.99e-054101237083525
Pubmed

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

OTX2 TP53

4.99e-05410129872327
Pubmed

Three distinct signalling responses by murine fibroblasts to genotoxic stress.

JAK1 TP53

4.99e-05410128918879
Pubmed

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

PIK3CA TP53

4.99e-054101224866151
Pubmed

Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers.

PIK3CA TP53

4.99e-054101230776175
Pubmed

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice.

TTK TP53

4.99e-054101233420244
Pubmed

Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.

SELP VCAN

4.99e-054101210950950
Pubmed

Distribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy.

PIK3CA TP53

4.99e-054101234012039
InteractionYWHAH interactions

TET2 NRIP1 DOCK11 SIPA1L3 TTK TTLL7 PIK3CA STARD9 KIAA1217 SHCBP1 SSX2IP MAST1 TNFAIP3 ARHGEF2 HERC1 PCM1 WDR62 ZC3HAV1

3.37e-0611029518int:YWHAH
InteractionRPGRIP1L interactions

TCHP SOBP SIPA1L3 TTK SSX2IP DYNC1H1 PCM1 TP53

1.13e-05225958int:RPGRIP1L
InteractionTRAM1L1 interactions

FAM209A PLEKHF2 CREB3L1 TP53

1.32e-0531954int:TRAM1L1
InteractionSTIL interactions

TCHP SIPA1L3 KIAA1217 SSX2IP PCM1 TP53 WDR62

3.25e-05190957int:STIL
InteractionCNTRL interactions

TCHP TTK SSX2IP ARHGEF2 DYNC1H1 PCM1 TP53

3.60e-05193957int:CNTRL
InteractionLATS1 interactions

TET2 TCHP SIPA1L3 JAK1 KIAA1217 SSX2IP ATP2A1 PCM1 TP53 WDR62

4.29e-054409510int:LATS1
InteractionNIN interactions

TCHP SIPA1L3 TTK KIAA1217 SSX2IP ARHGEF2 DYNC1H1 PCM1 TP53

4.99e-05359959int:NIN
Cytoband8p11.2

ASH2L CHRNB3

4.29e-041410128p11.2
Cytoband20q13.31

FAM209A FAM209B

5.64e-0416101220q13.31
GeneFamilyTubulin tyrosine ligase family

TTLL7 TTLL4

1.50e-0314752779
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 PLEKHF2 CERT1 DEF6 ARHGEF2

1.65e-03206755682
GeneFamilyStAR related lipid transfer domain containing

CERT1 STARD9

1.72e-0315752759
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB6 ZBTB17 KLHL38 ZBTB44

2.33e-03134754861
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|lymph-node_spleen / Manually curated celltypes from each tissue

PRUNE2 SRRM5 TTLL7 SHCBP1 NEIL3 WDR62

3.74e-061841006f93373fcde5c31f4ffe67ca0f3ea7f4e906dc88b
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

AHCTF1 USP24 TNFAIP3 HERC1 DYNC1H1 ZC3HAV1

4.23e-061881006ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellfacs-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 KRT35 TMPRSS4 TTLL7 LYPD5 WDR62

4.23e-061881006ed35e438796cef302b6787c111753425922792dc
ToppCellCOVID-19-kidney-Proliferating_T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

OR5M8 TTK SHCBP1 DEF6 NEIL3 WDR62

4.63e-061911006bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCellIPF-Endothelial-VE_Venous|Endothelial / Disease state, Lineage and Cell class

SELP ADGRB3 CHST11 LEPR NAV3 TNFAIP3

5.06e-061941006e8a9005963704286bcc50785bda8d7d63ec001b1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 CHST11 HEG1 STARD9 NAV3

5.06e-061941006a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

OR5M8 TTK SHCBP1 DEF6 NEIL3 WDR62

5.22e-0619510067e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 ABCG1 HEG1 KCNN3 TNFAIP3

5.22e-061951006818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

ADGRG4 CHRNB3 BRS3 SLC6A5 MAEL

6.20e-061151005c724e8b1fddcefdaa8d247aaff68c986538068f7
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3-Excitatory_Neuron.Slc17a7-Slc17a6.Nxph3-Cbln2-Kcnh8_(Deep_layer_subiculum)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ABCA12 SAXO1 ZP2 TACR2

7.18e-065510045ce0008811bb696191923de9b34ea6e0d8d39a7a
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cbln2_(Neuron.Slc17a6.Rora.Cbln2)|Thalamus / BrainAtlas - Mouse McCarroll V32

ABCA12 SLURP1 TMPRSS4 SLC6A5

1.58e-056710045202166895fd109ad0d7584fc35c74814a59ce2b
ToppCellDividing_Macrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

FAM209A TTK SHCBP1 MAST1 NEIL3

3.65e-051661005c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRRN1 ABCA12 SHCBP1 DEF6 C5

3.65e-05166100543f84d3cd58e93ce00c241656c4cba27604b4932
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 LRP8 HEG1 FAM209B

3.98e-0516910057c994653b0d629dfb046755d6b678452de0a15d2
ToppCellLymphoid-Lymphoid-T_cells_(Cd8+_T_cell)|Lymphoid / shred on cell class and cell subclass (v4)

ZBTB6 PI4K2A CREB3L1 SSX2IP TNFAIP3

4.09e-05170100520fd1a312c81c1bf3c5d2d6caf9b578e6b7a4171
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAD1 PDE3A PTGDR ADGRG4 NAV3

4.70e-051751005795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellRSV-Healthy-2|Healthy / Virus stimulation, Condition and Cluster

SOBP TTK SHCBP1 NEIL3 WDR62

4.70e-051751005c47440c0b0513e67fe13b85f10dd8a8d42d0e9a3
ToppCellRSV-Healthy-2|RSV / Virus stimulation, Condition and Cluster

SOBP TTK SHCBP1 NEIL3 WDR62

4.70e-0517510050e97189585b7afaf3bd622c3ef10c86412393829
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHCBP1 KCNN3 NEIL3 TP53 WDR62

5.23e-051791005df4d0b2fe47d2c7def729b3217cb01ced01495ff
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TTK TTLL4 C9orf50 NEIL3 ATP2A1

5.37e-0518010055e1680088065be14447d5d5465f91f7edd071a1e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE3A NCKAP5 CHST11 CHRNB3 HEG1

5.51e-0518110052f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCelldroplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 ADAD1 LEPR ABCG1 KCNN3

5.80e-051831005ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SELP ADGRB3 LEPR HEG1 NAV3

5.80e-051831005c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell|TCGA-Uvea / Sample_Type by Project: Shred V9

CHST11 TNFRSF21 LRP8 KLHL38 SHCBP1

6.27e-051861005e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ZYG11A SOBP SIPA1L3 NCKAP5

6.27e-0518610055784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 SOBP SIPA1L3 NCKAP5 TNFRSF21

6.43e-0518710053ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 ABCG1 HEG1 STARD9 NAV3

6.43e-05187100535c382c0aabd46906113e5db30ea24bb8e658899
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A PTGDR ADGRG4 KIAA1217 NAV3

6.93e-051901005efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellfacs-Tongue-nan-3m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 KRT35 TTLL7 LYPD5 WDR62

6.93e-051901005719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SRRM4 ADGRB3 NCKAP5 NAV3 FOXI1

7.11e-0519110058f4637e801554e2343b974fe7794f01dd2151418
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PDE3A LRRN1 DOCK11 CREB3L1 NAV3

7.11e-051911005156b467187331ac6ca390d6ca861d9670bb7b956
ToppCellfacs-Tongue-nan-18m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 KRT35 TTLL7 LYPD5 WDR62

7.11e-05191100502f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCell(3)_Macrophage_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TTK ABCG1 SHCBP1 LYPD5 NEIL3

7.11e-051911005b42f0b89bb94fd43786ff50f1caeb3ebfbbb43fd
ToppCellfacs-Trachea-nan-18m-Epithelial-keratinocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 KRT35 TTLL7 LYPD5 WDR62

7.28e-0519210054530b3028928d089b3a71eb19a4df237f58a50ae
ToppCellfacs-Trachea-nan-18m-Epithelial-new-cluster|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA12 KRT35 TTLL7 LYPD5 WDR62

7.28e-051921005e4fb3f18da7dc6a835023db69a8d99737c39ef86
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-keratinocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA12 KRT35 TTLL7 LYPD5 WDR62

7.65e-051941005bd94d30584128628b34ed8c3857ce103586cfe2e
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZBTB6 LRRN1 TMPRSS4 NAV3 FOXI1

7.65e-051941005ea5b7727ffef6cb454c501979a51bc1d4108d0e4
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial-keratinocyte-new-cluster|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA12 KRT35 TTLL7 LYPD5 WDR62

7.65e-051941005b847c5b4e8914b1c306bfff3d7119c32063784a8
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLURP1 TMPRSS4 CREB3L1 OTX2 SLC15A2

7.83e-051951005b9a1c5836eb0ca92df788c3ee093b0d9ec7b8ad9
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SELP PDE3A LEPR HEG1 NAV3

7.83e-051951005023e3c97dd3696d74f002ff8da0c04d876c82aef
ToppCellNS-moderate-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRN1 TMPRSS4 CREB3L1 SLC15A2 KIAA1217

8.03e-05196100570384c1da9baed843f414cfd1403ddd586a2db07
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 CHST11 HEG1 NAV3

8.03e-051961005023312af38f816a44b407e0daa32590d953caf99
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 HEG1 STARD9 NAV3

8.03e-051961005ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELP TTK LEPR SHCBP1 NEIL3

8.03e-051961005eb8c9a4a5eb21d43ff7b25deae5896c236f669b9
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 PDE3A TTLL7 TACR2 MAEL

8.03e-0519610059830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRB3 ABCG1 HEG1 STARD9 NAV3

8.22e-0519710050f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 HEG1 STARD9 NAV3

8.22e-051971005412cb5f37df57121ddd1492021445479c7cbccbf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 CHST11 HEG1 NAV3

8.42e-05198100531ba87552be97c9b78c9e82f98e96699ccb19824
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

ADGRB3 ABCG1 HEG1 STARD9 KCNN3

8.42e-0519810058689090bce9ab6e8f122426a404037e572c6713b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELP ADGRB3 HEG1 STARD9 NAV3

8.42e-0519810050a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TET2 NRIP1 DOCK11 ABCG1 VCAN

8.62e-0519910055b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SELP LEPR HEG1 KCNN3 CCL15

8.62e-05199100553b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TET2 TMPRSS4 CREB3L1 SLC15A2 KIAA1217

8.62e-05199100532bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

SELP LEPR HEG1 KCNN3 CCL15

8.62e-0519910059c753043024871b1f1436fc39defac4da85e10cd
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NCKAP5 TTK SHCBP1 NEIL3 WDR62

8.62e-0519910051d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCellBiopsy_Other_PF-Epithelial-Proliferating_Epithelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

TMPRSS4 TTK SHCBP1 NEIL3 WDR62

8.62e-051991005d73667e2e93026d95184e24ff0bc90afd1fb74a9
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SELP LEPR HEG1 KCNN3 CCL15

8.62e-051991005d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TET2 TMPRSS4 CREB3L1 SLC15A2 KIAA1217

8.62e-051991005262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellSepsis-URO-Lymphocyte-B-Plasmablast|URO / Disease, condition lineage and cell class

GPN1 TTK TNFRSF21 SHCBP1 KCNN3

8.62e-0519910050df6cafb7f3b607cbe80b6f25b4fd62d421d01ee
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-052001005a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-052001005dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-0520010053bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-05200100521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADGRG4 LEPR STARD9 VCAN NAV3

8.83e-0520010053dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A LEPR STARD9 VCAN NAV3

8.83e-052001005c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-052001005a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

NRIP1 DOCK11 NCKAP5 CHST11 NAV3

8.83e-05200100533036d21c1c82109284473a515c4f890b33fdd5c
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE3A ADGRG4 LEPR VCAN NAV3

8.83e-05200100574e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Ccnb1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NCKAP5 TTK NEIL3 WDR62

2.04e-041291004ff74d159034a09f7b174da18bfb9a26936252b4c
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTK SHCBP1 NEIL3 WDR62

2.23e-04132100402491930097b75aaeedab9e8200711b0dc610944
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAD1 TTK NEIL3 WDR62

2.36e-0413410044d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2|TCGA-Bladder / Sample_Type by Project: Shred V9

PRUNE2 SOBP ADGRG4 TACR2

2.87e-0414110041baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTK OTX2 SHCBP1 NEIL3

2.95e-0414210047bd05d0c0ac2dee0e6cc0f3c531f9154bf300c75
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTK OTX2 SHCBP1 NEIL3

2.95e-041421004328d08ba2712cd42bb9846ac4d7453ae165b75e2
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTK OTX2 SHCBP1 NEIL3

2.95e-04142100494774d3e598d074f48146b0b094705dc48af5a1f
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TTK OTX2 SHCBP1 NEIL3

2.95e-04142100492bf826827b3e3387ad326566556fc90c5c2f4d5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA12 TTK LRP8 SHCBP1

3.11e-041441004f6061dd965a2b2fe6ad864f8aecc06d2e74881ce
ToppCellAT1-AT2_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

NCKAP5 TTLL7 HEG1 SLC15A2

3.19e-041451004cd5de30fd948024e3ad043c9411ce9f2722178b2
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRRN1 ABCA12 SAXO1 KCNN3

3.54e-041491004c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRRN1 ABCA12 SAXO1 KCNN3

3.54e-041491004a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMPRSS4 SLC15A2 KIAA1217 PADI6

3.82e-0415210041b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTK LYPD5 MAST1 NEIL3

4.21e-041561004b3f10cd044f24807576e7d56e51df7064dbf6c50
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMPRSS4 LEPR KCNC4 TP53

4.21e-041561004ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABCA12 SOBP NCKAP5 TNFRSF21

4.31e-04157100419c0599a669803c4db1f174de1ce755e562a50a3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA12 KRT35 EYA3 KCNC4

4.31e-0415710042c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCellFetal_29-31_weeks-Immune-mast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SELP PTGDR MAST1 TNFAIP3

4.42e-0415810040c27c475289c70b17b6a66fc71f628511c5f0ae1
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA12 TMPRSS4 CERT1 C9orf50

4.52e-04159100422427ad4ad2e797e4664e7a7b0514094f22a18b2
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

ABCA12 ZP2 TACR2

4.60e-04671003b80bdd122a0284611161c40ec7a9c893dc8de4de
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TTK SHCBP1 NEIL3 WDR62

4.74e-0416110040dd1401b4c990d49fccb702a9f9867590a58e203
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TTK SHCBP1 NEIL3 WDR62

4.74e-041611004b6a31c033edc74f23a20aab1f18e80cc83ffee4c
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TTK SHCBP1 NEIL3 WDR62

4.74e-041611004efb811dda4d73107983a5f68302bdcf4f408d5b4
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TTK SHCBP1 NEIL3 WDR62

4.74e-04161100428d5dbd20c9f8e0069f172d552997a044790e1a7
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Cplx3-Hs6st2_(Entorhinal_cortex)|Hippocampus / BrainAtlas - Mouse McCarroll V32

SAXO1 CHRNB3 MAEL

4.81e-0468100375e81b353ef313d5e98d5c98d584335f1d1fa658
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Cplx3-Hs6st2_(Entorhinal_cortex)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

SAXO1 CHRNB3 MAEL

4.81e-0468100301ba0ccc5732189a5c0c32cb7819289102711b93
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTK SHCBP1 NEIL3 WDR62

4.97e-0416310045285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SAXO1 JAK1 TNFAIP3 ZC3HAV1

4.97e-04163100411cc18f36604d9a5f4e7fb8626a8f0fb141da5e1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3A ADGRB3 STARD9 PADI6

5.08e-041641004f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCellDividing_Macrophages-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

TTK SHCBP1 LYPD5 NEIL3

5.32e-041661004ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRRN1 TTK NEIL3 WDR62

5.44e-04167100450c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP8 UCHL3 TNFAIP3 ATP2A1

5.44e-041671004e0f2509e86302eca8352821bce12597f6c51fc24
DrugFlurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A

SIPA1L3 EYA3 MAPK8IP3 SLC15A2 SSX2IP EHMT1 PCM1 WDR62

2.57e-0619710084702_DN
DiseaseMalformations of Cortical Development

PIK3CA DYNC1H1 WDR62

1.11e-0514943C1955869
DiseaseCortical Dysplasia

PIK3CA DYNC1H1 WDR62

1.11e-0514943C0431380
DiseaseMalignant neoplasm of penis

PIK3CA TP53

6.00e-054942C0153601
DiseasePenile Neoplasms

PIK3CA TP53

6.00e-054942C0030849
Diseasestomach cancer (is_implicated_in)

TET2 JAK1 PIK3CA TP53

8.42e-0572944DOID:10534 (is_implicated_in)
Diseasedisease of cellular proliferation (implicated_via_orthology)

JAK1 TP53

2.09e-047942DOID:14566 (implicated_via_orthology)
DiseaseColorectal Neoplasms

TET2 ABCA12 ABCG1 PIK3CA ZKSCAN3 TP53

2.64e-04277946C0009404
DiseasePolycythemia Vera

TET2 JAK1

2.78e-048942C0032463
Diseasehepatocellular carcinoma (is_implicated_in)

TET2 LEPR JAK1 PIK3CA TP53

2.90e-04181945DOID:684 (is_implicated_in)
DiseaseHEPATOCELLULAR CARCINOMA

PIK3CA TP53

3.56e-049942114550
DiseaseAdult Hepatocellular Carcinoma

PIK3CA TP53

3.56e-049942C0279607
DiseaseHepatocellular carcinoma

PIK3CA TP53

3.56e-049942cv:C2239176
DiseaseHead and Neck Carcinoma

PIK3CA TP53

4.44e-0410942C3887461
Diseasecolorectal cancer (is_implicated_in)

JAK1 PIK3CA TNFAIP3 TP53

6.17e-04121944DOID:9256 (is_implicated_in)
DiseaseB-Cell Lymphomas

TNFAIP3 TP53

6.49e-0412942C0079731
DiseaseThrombocythemia, Essential

TET2 TP53

6.49e-0412942C0040028
DiseaseMouth Neoplasms

GPN1 PIK3CA TP53

6.90e-0454943C0026640
DiseaseMalignant neoplasm of mouth

GPN1 PIK3CA TP53

6.90e-0454943C0153381
DiseaseSarcomatoid Renal Cell Carcinoma

TET2 PIK3CA NAV3 TP53

7.62e-04128944C1266043
DiseaseChromophobe Renal Cell Carcinoma

TET2 PIK3CA NAV3 TP53

7.62e-04128944C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

TET2 PIK3CA NAV3 TP53

7.62e-04128944C1266044
DiseasePapillary Renal Cell Carcinoma

TET2 PIK3CA NAV3 TP53

7.62e-04128944C1306837
DiseaseRenal Cell Carcinoma

TET2 PIK3CA NAV3 TP53

7.62e-04128944C0007134
DiseaseFetal Alcohol Spectrum Disorders

OTX2 PIK3CA

7.65e-0413942C2985290
DiseaseAdenocarcinoma Of Esophagus

PIK3CA TP53

8.91e-0414942C0279628
DiseaseSarcoma, Spindle Cell

PIK3CA TP53

8.91e-0414942C0205945
DiseaseSarcoma, Epithelioid

PIK3CA TP53

8.91e-0414942C0205944
Diseasenasopharynx carcinoma (is_implicated_in)

TET2 TP53

1.03e-0315942DOID:9261 (is_implicated_in)
Diseaseupper aerodigestive tract neoplasm

PRUNE2 NCKAP5 KCNC4 ZKSCAN3 TP53

1.16e-03246945EFO_0004284
DiseaseInherited oocyte maturation defect

ZP2 PADI6

1.17e-0316942cv:CN238505
Diseasehemorrhoid

TET2 TMPRSS4 KIAA1217 TP53

1.27e-03147944EFO_0009552
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

TET2 PIK3CA NAV3 TP53

1.31e-03148944C0279702
DiseaseAstrocytosis

TNFRSF21 LEPR

1.32e-0317942C3887640
DiseaseAntibody Deficiency Syndrome

LEPR C5

1.32e-0317942C0003257
DiseaseGliosis

TNFRSF21 LEPR

1.32e-0317942C0017639
DiseaseFetal Alcohol Syndrome

OTX2 PIK3CA

1.32e-0317942C0015923
Diseasediabetic nephropathy

LRP8 JAK1 OTX2 NAV3

1.37e-03150944EFO_0000401
Diseaseglucose measurement

TET2 OR9G1 PTGDR OR9G9 HERC1 TP53

1.38e-03380946EFO_0004468
DiseasePancreatic carcinoma

TCHP TP53

1.66e-0319942C0235974
Diseasecytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant

FAM209A FAM209B

1.66e-0319942EFO_0007044, EFO_0020106
Diseaseesophagus squamous cell carcinoma (is_marker_for)

TET2 EHMT1 TNFAIP3

1.72e-0374943DOID:3748 (is_marker_for)
Diseasebirth weight

TET2 NRIP1 ABCG1 KCNN3 ARHGEF2 TP53

1.76e-03399946EFO_0004344
Diseasebrain measurement, neuroimaging measurement

GDF5-AS1 NCKAP5 CHRNB3 LRP8 VCAN NAV3 MAEL

1.91e-03550947EFO_0004346, EFO_0004464
DiseaseBREAST CANCER

PIK3CA TP53

2.03e-0321942114480
DiseaseStomach Carcinoma

TCHP PIK3CA

2.03e-0321942C0699791
DiseaseSarcoma

PIK3CA TP53

2.03e-0321942C1261473
Diseasecolorectal carcinoma (is_implicated_in)

PIK3CA TP53

2.23e-0322942DOID:0080199 (is_implicated_in)
DiseaseGranulomatous Slack Skin

TNFAIP3 TP53

2.23e-0322942C0376407
DiseaseNasopharyngeal carcinoma

PIK3CA TP53

2.23e-0322942C2931822
DiseaseNerve Degeneration

LRP8 OTX2 KCNJ4

2.39e-0383943C0027746
DiseaseImmunologic Deficiency Syndromes

LEPR C5

2.43e-0323942C0021051
DiseaseCarcinoma of lung

PIK3CA TP53

2.43e-0323942C0684249
DiseaseLymphoma, T-Cell, Cutaneous

TNFAIP3 TP53

2.43e-0323942C0079773
Diseaseairway responsiveness measurement

SOBP USP24

2.65e-0324942EFO_0006897
Diseasebreast cancer (implicated_via_orthology)

PIK3CA TP53

2.87e-0325942DOID:1612 (implicated_via_orthology)
Diseasepseudotumor cerebri

OR9G1 OR9G9

3.10e-0326942EFO_1001132

Protein segments in the cluster

PeptideGeneStartEntry
CCSKVQNYSMPTSSF

PRAMEF33

181

A0A0G2JMD5
CSYAFMFSSLRQKTS

FAM209A

16

Q5JX71
PASYKSSCTMDVTFF

CHRNB3

146

Q05901
YLSEDTSMNSSLPFC

C9orf50

356

Q5SZB4
ISRPYKMAATQTGTC

CREB3L1

361

Q96BA8
TCMNPSAYQRTYSMK

VCAN

3351

P13611
ASSYSAEMTEPKSVC

ABCG1

16

P45844
PTATKSTVSFYNVEM

ADGRG4

2236

Q8IZF6
SYSVSEMFPKNFTNC

ADGRB3

41

O60242
TKMSPSSLYSQQVLC

SSX2IP

26

Q9Y2D8
PFKDRATSMCSYGTK

ABCA12

2381

Q86UK0
FSGPSAEQMCKTYSE

ARHGEF2

326

Q92974
YCPKDGVNRISSMSS

ADAD1

371

Q96M93
SIPCSLMKSYFETSS

CCL15

61

Q16663
LMKSYFETSSECSKP

CCL15

66

Q16663
RKSMSVYCSPAKSSR

ATP2A1

491

O14983
IDTSSCLPFMTNYSF

ASH2L

131

Q9UBL3
MKSPFYRCQNTTSVE

PTGDR

1

Q13258
PRSSYSFDMDKIVST

OR9G1

261

Q8NH87
PRSSNDYTSQMYSAK

EYA3

61

Q99504
TYCDSDSSPMALFLK

JAK1

1076

P23458
SNKSQRYMADIFTTC

KCNJ4

36

P48050
RFVQKPYSRSSSMSS

CERT1

366

Q9Y5P4
MAFCYTQAPHKTTSL

PADI6

361

Q6TGC4
SNCDTSLSPYMSQKD

MAEL

411

Q96JY0
SSDRAASSFIPYCSM

MAPK8IP3

1211

Q9UPT6
STVFSHLMKYPCNTF

NEIL3

356

Q8TAT5
RAVCTKLANMYSTST

HHLA3

51

Q9XRX5
MASDYSRTCASPDSI

HERC1

346

Q15751
VKNIRYESASMSSTC

PCM1

1311

Q15154
YESASMSSTCEPCKS

PCM1

1316

Q15154
DSNPFTEIAMSSCKY

KCNN3

166

Q9UGI6
RKASACSTYAPETMM

PDE3A

651

Q14432
SCTSPTKMDLSYSKT

NAV3

651

Q8IVL0
CSYAFMFSSLRQKTS

FAM209B

16

Q5JX69
YSSTQPSSCMDNRTF

NRIP1

986

P48552
KTFASYMPQFQTCST

LEPR

1136

P48357
TRVSAMYSSSSCKLP

KRT35

26

Q92764
NMCFSALPSYIRSTV

HEG1

1101

Q9ULI3
SVTCTYSPALNKMFC

TP53

121

P04637
PRSSYSFDMDKIVST

OR9G9

261

P0C7N8
TNPVTFMSNMLYACS

GPN1

161

Q9HCN4
CFTMPSYSRRISTAT

PIK3CA

301

P42336
SCSPRFSKVYSSMEQ

MAST1

706

Q9Y2H9
IKYDCPMDSSSSRDT

PI4K2A

316

Q9BTU6
TLYSCAAMPNSASRD

DOCK11

1186

Q5JSL3
PDKQCTMFYSTSNIK

C5

1501

P01031
SPSFSRALMSNTYLC

GDF5-AS1

186

Q5U4N7
FCVKTANRTYEMSAS

DEF6

281

Q9H4E7
SMDCSPSLRAFQYDT

SELP

396

P16109
YLCNRKSMTQPFTSA

LYPD5

211

Q6UWN5
TACSSIYFTMESLKQ

DYNC1H1

3806

Q14204
CSEFIQQSSMKSPLY

AHCTF1

1131

Q8WYP5
PCLNSFLSSMTAYVS

FOXI1

276

Q12951
EFSYSQAPSSMKSVL

SLC15A2

631

Q16348
YMATTKSQTACLPFV

EHMT1

266

Q9H9B1
ALASPQCFYSTVTMD

TACR2

161

P21452
MKRCYRAPQSTSTTT

LRP8

731

Q14114
DTKPTQVDTSRSYYM

LRRN1

701

Q6UXK5
MATCQPARSDSYSQS

PLEKHF2

216

Q9H8W4
RSCTPAYSMQGRAKS

ODF3L2

101

Q3SX64
SDPLSTSSSCMQRSY

OTX2

161

P32243
AAKTSCLYNDPEMSS

PRUNE2

3061

Q8WUY3
FSDVPSSVMKCKAYT

TNFRSF21

176

O75509
TTYTISFTPKEMGRC

SAXO1

406

Q8IYX7
IKNSTFCMTAYPNVT

SLC6A5

341

Q9Y345
ATGTQDKAPRMCTYS

NCKAP5

1856

O14513
YTSSPSCMSLAKAPR

SIPA1L3

1316

O60292
RTAIRSASAYCNPSM

KIAA1217

426

Q5T5P2
YTCKEPMTSASCRTI

SLURP1

26

P55000
SFVDLCFSSNVTPKM

OR5M8

66

Q8NGP6
CSYRDKPGSSLQSFM

SHCBP1

46

Q8NEM2
YMSGSAVDVSCSQKP

STARD9

3486

Q9P2P6
AVAMCSRYDSIPVST

PSMG4

51

Q5JS54
RFFKTTMGSDYCPSE

TEX45

366

Q8NA69
FRDPNKNMTFESCTS

BRS3

191

P32247
KNMTFESCTSYPVSK

BRS3

196

P32247
FPTYAKSTRTTDEMT

CHST11

301

Q9NPF2
TSSVYFMKQTISNAC

UCHL3

81

P15374
SSFPSRKMFCQYDSR

ZNF33B

131

Q06732
SPFLFSETTAMKCRS

TNFAIP3

466

P21580
VKMSRPTQYSSFSCH

SPEM2

96

Q0P670
SYSPTEMSSRVKSYN

SRRM5

256

B3KS81
RYSLSMGSEVKSFCS

SOBP

161

A7XYQ1
ARSSPMKGCSRSSSY

SRRM4

381

A7MD48
MADYVTCESTKTTLP

ZBTB44

266

Q8NCP5
AETACRQMGYSSKPT

TMPRSS4

136

Q9NRS4
YTNMMSDVSEPCSTR

ZNF281

871

Q9Y2X9
CCSKVQNYSMPTSSF

PRAMEF10

181

O60809
QNSRYFRMSDICSSK

TCHP

36

Q9BT92
VYMKAATPFSCSSSI

ZNF518A

506

Q6AHZ1
ANYQSTSNTSMLKCP

ZSWIM2

181

Q8NEG5
APSTCSYMEATASSR

WDR62

1206

O43379
VYSKLTMFCTTNSLP

ZBED5

21

Q49AG3
DYCGRSFSDPTSKMR

ZBTB17

421

Q13105
SRQMSLCGTPEKSSY

USP24

1281

Q9UPU5
CKTPSSNTLDDYMSC

TTK

451

P33981
TPMSYKCNECERSFT

ZKSCAN3

476

Q9BRR0
SYTINFRVMSCDSFP

ZC3HAV1

571

Q7Z2W4
LVRFASCKYSPSMKS

TTLL4

786

Q14679
NSPYSQTMKSSACKI

TET2

816

Q6N021
PSSSCKMTALVTYRS

ZYG11A

656

Q6WRX3
ASTICQKDFMSFSLP

ZP2

151

Q05996
DSEFRMTVKCSYSRN

ZP2

456

Q05996
MKRPKYCSSDSSYDS

TTLL7

541

Q6ZT98
SQPCTSSKASMYFSE

ZBTB6

236

Q15916
MYCKSEETSPRDSTC

KCNC4

506

Q03721
VLASSSPYFRAMFCS

KLHL38

51

Q2WGJ6