Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	8.03e-05	3	104	2	GO:0005220
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR3 ITPR1 ITPR2	1.06e-04	18	104	3	GO:0015278
GeneOntologyMolecularFunction	dATP binding	ST13 ST13P5	2.66e-04	5	104	2	GO:0032564
GeneOntologyMolecularFunction	adenyl deoxyribonucleotide binding	ST13 ST13P5	3.98e-04	6	104	2	GO:0032558
GeneOntologyMolecularFunction	purine deoxyribonucleotide binding	ST13 ST13P5	5.55e-04	7	104	2	GO:0032554
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR3 ITPR1 ITPR2	5.55e-04	31	104	3	GO:0099604
GeneOntologyMolecularFunction	calcium channel activity	RYR3 ITPR1 ITPR2 CUL5 GRIN3A	5.74e-04	129	104	5	GO:0005262
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR3 ITPR1 ITPR2	6.68e-04	33	104	3	GO:0005217
GeneOntologyMolecularFunction	deoxyribonucleotide binding	ST13 ST13P5	9.44e-04	9	104	2	GO:0032552
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	RYR3 ITPR1 ITPR2 CUL5 GRIN3A	1.17e-03	151	104	5	GO:0015085
GeneOntologyCellularComponent	nuclear pore inner ring	NUP205 NUP188	7.76e-05	3	107	2	GO:0044611
Domain	TPR_1	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	3.74e-08	90	104	8	IPR001440
Domain	TPR_1	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	3.74e-08	90	104	8	PF00515
Domain	TPR-contain_dom	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	1.93e-06	150	104	8	IPR013026
Domain	ARM-type_fold	NCAPD3 DNAJC13 AP3B1 RYR3 ITPR1 ITPR2 FOCAD VAC14 MROH2B NUP188 AGTPBP1	2.97e-06	339	104	11	IPR016024
Domain	RIH_assoc-dom	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	IPR013662
Domain	Ins145_P3_rec	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	PF08709
Domain	RIH_assoc	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	PF08454
Domain	RIH_dom	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	IPR000699
Domain	Ins145_P3_rcpt	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	IPR014821
Domain	Ryanodine_recept-rel	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	IPR015925
Domain	-	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	1.25.10.30
Domain	RYDR_ITPR	RYR3 ITPR1 ITPR2	3.31e-06	6	104	3	PF01365
Domain	TPR_REGION	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	3.93e-06	165	104	8	PS50293
Domain	TPR	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	3.93e-06	165	104	8	PS50005
Domain	TPR-like_helical_dom	ADCY10 ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5 RGPD5	6.16e-06	233	104	9	IPR011990
Domain	TPR	ST13P4 RGPD8 TMTC2 IFIT2 ST13 TTC22 ST13P5	7.76e-06	129	104	7	SM00028
Domain	MIR	RYR3 ITPR1 ITPR2	1.96e-05	10	104	3	PF02815
Domain	MIR_motif	RYR3 ITPR1 ITPR2	1.96e-05	10	104	3	IPR016093
Domain	MIR	RYR3 ITPR1 ITPR2	1.96e-05	10	104	3	PS50919
Domain	MIR	RYR3 ITPR1 ITPR2	1.96e-05	10	104	3	SM00472
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	9.18e-05	3	104	2	IPR000493
Domain	SHR-BD	VPS13C VPS13B	1.83e-04	4	104	2	IPR009543
Domain	VPS13_C	VPS13C VPS13B	1.83e-04	4	104	2	PF16909
Domain	VPS13_C	VPS13C VPS13B	1.83e-04	4	104	2	IPR031645
Domain	SHR-BD	VPS13C VPS13B	1.83e-04	4	104	2	PF06650
Domain	Autophagy-rel_C	VPS13C VPS13B	3.04e-04	5	104	2	IPR015412
Domain	ATG_C	VPS13C VPS13B	3.04e-04	5	104	2	PF09333
Domain	LRR_8	ECM2 LRSAM1 SLITRK3 DCN IGFALS PODN	3.90e-04	171	104	6	PF13855
Domain	LRR_TYP	ECM2 LRSAM1 SLITRK3 DCN IGFALS PODN	4.69e-04	177	104	6	SM00369
Domain	Leu-rich_rpt_typical-subtyp	ECM2 LRSAM1 SLITRK3 DCN IGFALS PODN	4.69e-04	177	104	6	IPR003591
Domain	Chorein_N	VPS13C VPS13B	8.41e-04	8	104	2	PF12624
Domain	Retinal_BS	OPN1SW RHO	8.41e-04	8	104	2	IPR027430
Domain	VPS13_N	VPS13C VPS13B	8.41e-04	8	104	2	IPR026854
Domain	MAGE	MAGEC3 MAGEC1 MAGEB17	8.85e-04	34	104	3	SM01373
Domain	TPR_repeat	RGPD8 TMTC2 IFIT2 ST13 TTC22	8.89e-04	133	104	5	IPR019734
Domain	MAGE	MAGEC3 MAGEC1 MAGEB17	1.05e-03	36	104	3	PS50838
Domain	MHD_dom	MAGEC3 MAGEC1 MAGEB17	1.05e-03	36	104	3	IPR002190
Domain	MAGE	MAGEC3 MAGEC1 MAGEB17	1.05e-03	36	104	3	PF01454
Domain	-	ADCY10 RGPD8 TMTC2 IFIT2 ST13 TTC22	1.06e-03	207	104	6	1.25.40.10
Domain	STI1	ST13 ST13P5	1.34e-03	10	104	2	SM00727
Domain	OPSIN	OPN1SW RHO	1.34e-03	10	104	2	PS00238
Domain	STI1_HS-bd	ST13 ST13P5	1.34e-03	10	104	2	IPR006636
Domain	LRR_1	ECM2 LRSAM1 SLITRK3 DCN IGFALS PODN	1.42e-03	219	104	6	PF00560
Domain	-	NCAPD3 DNAJC13 AP3B1 VAC14 MROH2B AGTPBP1	1.52e-03	222	104	6	1.25.10.10
Domain	Grip	RGPD8 RGPD5	1.63e-03	11	104	2	SM00755
Domain	GRIP	RGPD8 RGPD5	1.63e-03	11	104	2	PF01465
Domain	Opsin	OPN1SW RHO	1.63e-03	11	104	2	IPR001760
Domain	Ran_BP1	RGPD8 RGPD5	1.95e-03	12	104	2	PF00638
Domain	RANBD1	RGPD8 RGPD5	1.95e-03	12	104	2	PS50196
Domain	GRIP_dom	RGPD8 RGPD5	1.95e-03	12	104	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	1.95e-03	12	104	2	PS50913
Domain	LRRNT	SLITRK3 DCN IGFALS PODN	2.19e-03	98	104	4	IPR000372
Domain	LRRNT	SLITRK3 DCN IGFALS PODN	2.19e-03	98	104	4	SM00013
Domain	RanBD	RGPD8 RGPD5	2.30e-03	13	104	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	2.30e-03	13	104	2	IPR000156
Domain	LRRNT	DCN IGFALS PODN	3.21e-03	53	104	3	PF01462
Domain	TPR_8	TMTC2 IFIT2 ST13	3.21e-03	53	104	3	PF13181
Domain	ARM-like	NCAPD3 DNAJC13 AP3B1 VAC14 MROH2B AGTPBP1	4.02e-03	270	104	6	IPR011989
Domain	Leu-rich_rpt	ECM2 LRSAM1 SLITRK3 DCN IGFALS PODN	4.09e-03	271	104	6	IPR001611
Domain	DH_1	KALRN PLEKHG5 FARP2	5.23e-03	63	104	3	PS00741
Domain	LRR	ECM2 LRSAM1 DCN IGFALS PODN	5.34e-03	201	104	5	PS51450
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD8 MAPKAPK2 ST13 NUP205 NUP188 ST13P5	2.19e-06	73	74	6	MM14948
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RGPD8 MAPKAPK2 ST13 NUP205 NUP188 ST13P5	8.50e-06	92	74	6	MM14951
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2 PPP3CA	2.22e-05	11	74	3	M27466
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR3 ITPR1 ITPR2	1.27e-04	19	74	3	M47760
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	2.69e-04	5	74	2	M49000
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	DGKG ITPR1 ITPR2	2.94e-04	25	74	3	MM14511
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 KALRN LRSAM1 CLIC6 DCN TRIM59 ST13 RYR3 FOCAD DIP2A PPP3CA HPF1 FBXO7 ROBO1 DHX35 AGTPBP1 DOP1B	4.03e-07	1285	107	17	35914814
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	VPS13C SLFN5 ZZEF1 CHRNB4 NUP205 ITPR2 FOCAD DIP2A ZBED4 NUP188 USP39 CNOT1 DOP1B	4.49e-07	736	107	13	29676528
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR3 ITPR1 ITPR2	5.62e-07	6	107	3	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR3 ITPR1 ITPR2	5.62e-07	6	107	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR3 ITPR1 ITPR2	5.62e-07	6	107	3	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR3 ITPR1 ITPR2	5.62e-07	6	107	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR3 ITPR1 ITPR2	9.82e-07	7	107	3	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2 PPP3CA	9.82e-07	7	107	3	22495310
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ST13P4 RGPD8 ST13 WASHC5 ST13P5 AGTPBP1 RGPD5	4.83e-06	215	107	7	35973513
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	9.38e-06	2	107	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	9.38e-06	2	107	2	15201137
Pubmed	Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene.	VAC14 HYDIN	9.38e-06	2	107	2	12719380
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	9.38e-06	2	107	2	23582047
Pubmed	Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function.	ADCY10 MAGEC3	9.38e-06	2	107	2	26857816
Pubmed	Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species.	RHO AGTPBP1	9.38e-06	2	107	2	36420970
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	9.38e-06	2	107	2	19120126
Pubmed	St13 protects against disordered acinar cell arachidonic acid pathway in chronic pancreatitis.	ST13 ST13P5	9.38e-06	2	107	2	35562743
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TTF2 RGPD8 VPS13C VARS2 ZZEF1 ST13 ITPR1 ITPR2 DIP2A MTX3 SEC24B FBXO7 DHX35 NUP188 VPS13B KIF2C	1.37e-05	1496	107	16	32877691
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 LRSAM1 RYR3 DIP2A KIAA0825 USP39 CNOT1 HYDIN KIF2C	2.40e-05	497	107	9	36774506
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DNAJC13 VPS13C ITPR1 ITPR2 VAC14 WASHC5 SEC24B VPS13B DOP1B	2.68e-05	504	107	9	34432599
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 PPP3CA	2.81e-05	3	107	2	21435446
Pubmed	Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity.	PMS1 CDK2	2.81e-05	3	107	2	36952545
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	2.81e-05	3	107	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	2.81e-05	3	107	2	9808793
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	2.81e-05	3	107	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	2.81e-05	3	107	2	17437169
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	2.81e-05	3	107	2	18194433
Pubmed	Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue.	ITPR1 PPP3CA	2.81e-05	3	107	2	12617961
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	2.81e-05	3	107	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	2.81e-05	3	107	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	2.81e-05	3	107	2	32320395
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	2.81e-05	3	107	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	2.81e-05	3	107	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	2.81e-05	3	107	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	2.81e-05	3	107	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	2.81e-05	3	107	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	2.81e-05	3	107	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	2.81e-05	3	107	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	2.81e-05	3	107	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	2.81e-05	3	107	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	2.81e-05	3	107	2	24904548
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	2.81e-05	3	107	2	17327232
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	2.81e-05	3	107	2	23223241
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	2.81e-05	3	107	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	2.81e-05	3	107	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	2.81e-05	3	107	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	2.81e-05	3	107	2	9858485
Pubmed	Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.	ITPR1 PPP3CA	2.81e-05	3	107	2	8521476
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	2.81e-05	3	107	2	20427533
Pubmed	SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study.	VPS13C GCH1	2.81e-05	3	107	2	27653855
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KALRN MAPKAPK2 ZZEF1 PLEKHG5 ITPR2 FOCAD DIP2A VAC14 POMGNT2 ZBED4 NUP188 SNAPC4 GGA1	3.59e-05	1105	107	13	35748872
Pubmed	Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.	OPN1SW RHO PPP3CA	3.62e-05	21	107	3	31696965
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	FYTTD1 AVL9 SLITRK3 GCNT4 CUL5 SEMA3D FBXO7 HERC6 HYDIN VPS13B	5.27e-05	686	107	10	29987050
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	5.60e-05	4	107	2	25215520
Pubmed	Polymorphism in MIR4697 but not VPS13C, GCH1, or SIPA1L2 is associated with risk of Parkinson's disease in a Han Chinese population.	VPS13C GCH1	5.60e-05	4	107	2	28380328
Pubmed	Expressions of rod and cone photoreceptor-like proteins in human epidermis.	OPN1SW RHO	5.60e-05	4	107	2	19493002
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	5.60e-05	4	107	2	21424589
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13B	5.60e-05	4	107	2	15498460
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	5.60e-05	4	107	2	21818117
Pubmed	Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum.	ITPR1 AGTPBP1	5.60e-05	4	107	2	2707487
Pubmed	Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis.	LRSAM1 AP3B1	5.60e-05	4	107	2	25380047
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	5.60e-05	4	107	2	28615414
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	5.60e-05	4	107	2	10828023
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR3 ITPR1	5.60e-05	4	107	2	23413940
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR3 ITPR1	5.60e-05	4	107	2	9607712
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	5.60e-05	4	107	2	9480752
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	5.60e-05	4	107	2	28419336
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	5.60e-05	4	107	2	19120137
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	5.60e-05	4	107	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	5.60e-05	4	107	2	35494252
Pubmed	Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway.	OPN1SW RHO	9.32e-05	5	107	2	31730232
Pubmed	Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse.	AP3B1 AGTPBP1	9.32e-05	5	107	2	8830098
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2	9.32e-05	5	107	2	21568942
Pubmed	Retinal Degeneration Slow (RDS) Glycosylation Plays a Role in Cone Function and in the Regulation of RDS·ROM-1 Protein Complex Formation.	OPN1SW RHO	9.32e-05	5	107	2	26420485
Pubmed	Characterization of FAM10A4, a member of the ST13 tumor suppressor gene family that maps to the 13q14.3 region associated with B-Cell leukemia, multiple myeloma, and prostate cancer.	ST13P4 ST13P5	9.32e-05	5	107	2	12079276
Pubmed	Spatiotemporal expression pattern of ceramide kinase-like in the mouse retina.	OPN1SW RHO	9.32e-05	5	107	2	21151604
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2	9.32e-05	5	107	2	11782428
Pubmed	The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.	OPN1SW RHO	9.32e-05	5	107	2	11055434
Pubmed	The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.	ITPR1 PPP3CA	9.32e-05	5	107	2	19706527
Pubmed	RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.	DNAJC13 WASHC5	9.32e-05	5	107	2	24643499
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DNAJC13 IQGAP2 KALRN AP3B1 PLEKHG5 ST13 ITPR2 CUL5 DIP2A PPP3CA WASHC5 ST13P5 CNOT1 AGTPBP1	1.27e-04	1431	107	14	37142655
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2	1.40e-04	6	107	2	21762810
Pubmed	Molecular genetic analysis of distal mouse chromosome 6 defines gene order and positions of the deafwaddler and opisthotonos mutations.	RHO ITPR1	1.40e-04	6	107	2	8530061
Pubmed	Architecture of the linker-scaffold in the nuclear pore.	NUP205 NUP188	1.40e-04	6	107	2	35679425
Pubmed	Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production.	CGAS STAT4	1.40e-04	6	107	2	36807146
Pubmed	Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.	OPN1SW RHO	1.40e-04	6	107	2	17436273
Pubmed	Retinal remodeling triggered by photoreceptor degenerations.	RHO AGTPBP1	1.40e-04	6	107	2	12866125
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TTF2 NCAPD3 AP3B1 NUP205 VAC14 TIMM21 LPCAT2 MTX3 SEC24B NUP188 CDK2	1.58e-04	942	107	11	31073040
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PMS1 NCAPD3 AP3B1 ZZEF1 ITPR1 FARP2 CUL5 DIP2A WASHC5	1.86e-04	650	107	9	38777146
Pubmed	BBS mutations modify phenotypic expression of CEP290-related ciliopathies.	RHO BBS7	1.95e-04	7	107	2	23943788
Pubmed	The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.	CGAS CUL5	1.95e-04	7	107	2	38418882
Pubmed	Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome.	NUP205 NUP188	1.95e-04	7	107	2	26878725
Pubmed	Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.	OPN1SW RHO	1.95e-04	7	107	2	18974269
Pubmed	PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation.	OPN1SW RHO	1.95e-04	7	107	2	31628458
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD5	1.95e-04	7	107	2	15710750
Pubmed	Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.	OPN1SW RHO	1.95e-04	7	107	2	19332056
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR3 ITPR1 ITPR2	2.21e-04	38	107	3	30786075
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 VPS13C ZZEF1 PLEKHG5 NUP205 WASHC5 NUP188 CNOT1	2.37e-04	529	107	8	14621295
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR3 ITPR2	2.59e-04	8	107	2	19033399
Pubmed	Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.	OPN1SW RHO	2.59e-04	8	107	2	21813673
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD8 TMTC2 IFIT2 ST13 TTC22 RGPD5	5.47e-06	115	70	6	769
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	4.42e-05	3	70	2	297
GeneFamily	MAGE family	MAGEC3 MAGEC1 MAGEB17	4.96e-04	40	70	3	1136
GeneFamily	Opsin receptors	OPN1SW RHO	7.95e-04	11	70	2	215
GeneFamily	Small leucine rich repeat proteoglycans	DCN PODN	9.51e-04	12	70	2	573
GeneFamily	EF-hand domain containing	RASGRP4 DGKG ZZEF1 RYR3 LPCAT2	1.59e-03	219	70	5	863
Coexpression	HOWARD_NEUTROPHIL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP	VPS13C CGAS GCH1 SLFN5 IFIT2 KIF24 NUP205 LPCAT2 HERC6 CMAHP	4.65e-06	394	106	10	M40996
Coexpression	GSE13485_DAY3_VS_DAY7_YF17D_VACCINE_PBMC_DN	GCH1 CLIC6 SLFN5 IFIT2 TDRD7 HERC6 KIF2C	1.64e-05	198	106	7	M3302
Coexpression	GSE33424_CD161_INT_VS_NEG_CD8_TCELL_UP	DNAJC13 CGAS SLFN5 IFIT2 ST13 TDRD7 HERC6	1.75e-05	200	106	7	M8554
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_TCELL_MEMBRANES_ACT_MAST_CELL_UP	ECM2 CGAS TMTC2 TRIM39 SLFN5 IFIT2 HERC6	1.75e-05	200	106	7	M7324
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FUT10 KALRN FAM221A CGAS VARS2 DHX35 NUP188 TRDMT1	7.19e-09	170	105	8	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FYTTD1 IFIT2 ITPR2 TDRD7 LPCAT2 BBS7 HERC6	1.22e-07	163	105	7	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	TTF2 AVL9 VPS13C ITPR2 MTX3 AGTPBP1 DOP1B	2.98e-07	186	105	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCHS2 CGAS GCH1 SLFN5 IFIT2 SEMA3D HERC6	3.83e-07	193	105	7	22455801194bd8c73c5c397f5eac4f723429c383
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAJC13 CGAS GCH1 IFIT2 TDRD7 GRIN3A	1.71e-06	153	105	6	859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKG SLITRK3 SLFN5 STAT4 ROBO1 GRIN3A	2.14e-06	159	105	6	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PMS1 FUT10 DCN FARP2 SEMA3D KIF2C	3.97e-06	177	105	6	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	NS-moderate-d_07-13-Myeloid-Monocyte-derived_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAJC13 GCH1 IFIT2 ITPR2 LAPTM5 LPCAT2	4.66e-06	182	105	6	e03e995e5fd14fc6a7559b83c0ca4e7ccc8e3d0f
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	TTF2 AVL9 VPS13C MTX3 AGTPBP1 DOP1B	5.12e-06	185	105	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PMS1 TTF2 CUL5 DIP2A BBS7 CNOT1	6.14e-06	191	105	6	d7920f4a602b50d0ef064eb47001e71939695ed2
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	NCAPD3 NUP205 SRRD ZBED4 ROBO1 NUP188	6.52e-06	193	105	6	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	CGAS GCH1 SLFN5 IFIT2 TDRD7 HERC6	6.92e-06	195	105	6	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	IIH-CD4-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	SLFN5 IFIT2 SEMA3D GRIN3A HERC6	2.67e-05	148	105	5	ec626a44cea83f2a0e5c27fc8182f96446d297ac
ToppCell	normal_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	MAPKAPK2 DGKG TRIM39 HPF1 KIF2C	2.75e-05	149	105	5	a34d095b8e0fe59d69d84e4fd2fe4ccb82f92e4f
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|356C / Donor, Lineage, Cell class and subclass (all cells)	GCH1 KIF24 TRIM59 RPP38-DT DIP2A	3.43e-05	156	105	5	7ccd20e3bbce6a070df45034b0bdc255f267efb1
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	KALRN ECM2 DGKG GCNT4 RYR3	3.99e-05	161	105	5	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRSAM1 IFIT2 TRIM59 POMGNT2 KIF2C	5.46e-05	172	105	5	ba36581ae339191a12a6d3ead39eaf69d78be10e
ToppCell	367C-Lymphocytic-ILC-ILC-2\|367C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG5 STAT4 WASHC5 NUP188 TTC22	5.61e-05	173	105	5	0451450605521fecb27a958628870d268adfb023
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCHS2 DGKG RYR3 DIP2A SEMA3D	6.26e-05	177	105	5	4c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13C CGAS SLFN5 IFIT2 HERC6	6.43e-05	178	105	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PLEKHG5 WASHC5 NUP188 TTC22 DOP1B	6.60e-05	179	105	5	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCN RYR3 PODN ROBO1 GRIN3A	6.95e-05	181	105	5	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ECM2 DCN PODN ROBO1 GRIN3A	7.71e-05	185	105	5	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	Smart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IQGAP2 SLFN5 STAT4 DIP2A PPP3CA	7.91e-05	186	105	5	fc0b488c201a32d829047b58460297df2818b45d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN DGKG SLITRK3 ROBO1 GRIN3A	8.11e-05	187	105	5	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ECM2 ASAP3 DCN SEMA3D PODN	8.11e-05	187	105	5	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN DGKG SLITRK3 ROBO1 GRIN3A	8.11e-05	187	105	5	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	KALRN DGKG RYR3 ITPR1 SEMA3D	8.32e-05	188	105	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN DGKG SLITRK3 ROBO1 GRIN3A	8.32e-05	188	105	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TTF2 AVL9 FAM221A TRIM39 TRIM59	8.53e-05	189	105	5	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	KALRN DGKG RYR3 ITPR1 SEMA3D	8.53e-05	189	105	5	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RASGRP4 RGPD8 PLEKHG5 LAPTM5 CMAHP	8.96e-05	191	105	5	b2759c1ce3793a0913d49b91576a9ab641dfea8f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 KALRN ECM2 DCN ROBO1	8.96e-05	191	105	5	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DCHS2 KALRN ECM2 DCN ROBO1	8.96e-05	191	105	5	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	(210)_NKT_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	FUT10 SLFN5 STAT4 DIP2A HERC6	9.18e-05	192	105	5	08dc0c019c594da7b9944db8fd706aa7780e6ae9
ToppCell	(21)_NKT_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	FUT10 SLFN5 STAT4 DIP2A HERC6	9.18e-05	192	105	5	b0a573ddde2978485a857b8261ee1ee5ef68ecef
ToppCell	BAL-Mild\|BAL / Compartment, Disease Groups and Clusters	CGAS GCH1 IFIT2 TDRD7 HERC6	9.18e-05	192	105	5	1a6cbf014d3f7a3fb6f53adab078c4742e7137de
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DCHS2 ECM2 DCN PODN ROBO1	1.04e-04	197	105	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLITRK3 DCN LPCAT2 PODN RGPD5	1.04e-04	197	105	5	ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	IQGAP2 SLFN5 STAT4 DIP2A TTC22	1.04e-04	197	105	5	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ECM2 SLITRK3 DCN PODN ROBO1	1.06e-04	198	105	5	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CGAS GCH1 IFIT2 LAPTM5 LPCAT2	1.09e-04	199	105	5	d3f77acb36ac7c56a47ca98b695f46ae5b9ecd12
ToppCell	distal-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ECM2 SLITRK3 DCN PODN ROBO1	1.09e-04	199	105	5	b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-FOXM1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TTF2 NCAPD3 KIF24 DHX35 KIF2C	1.09e-04	199	105	5	98575fcce726589e93fbb4df1aab03e57cb56076
ToppCell	Neuronal-Excitatory-eE(FEZF2_SLC17A7)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCHS2 DGKG RYR3 ITPR2 SEMA3D	1.11e-04	200	105	5	501cd2b4e55444fc5fdd93ebbcfc0616442b110b
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCN RYR3 PODN ROBO1 GRIN3A	1.11e-04	200	105	5	2086024ce808b8796ed508a229b098eb02f8828a
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DCN RYR3 PODN ROBO1 GRIN3A	1.11e-04	200	105	5	35951db6a4f442ac9e13f1b8cc5b4a33481f92c8
ToppCell	Bronchus_Control_(B.)-Immune-TX-DCs\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	KBTBD8 ITPR2 LAPTM5 LPCAT2 ADAMDEC1	1.11e-04	200	105	5	e0beacb88bbdc353a3e883171613027feafcf1ef
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	1.16e-05	2	101	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	1.16e-05	2	101	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	1.16e-05	2	101	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	1.16e-05	2	101	2	C1140716
Disease	polymyositis (is_implicated_in)	PMS1 STAT4	3.47e-05	3	101	2	DOID:0080745 (is_implicated_in)
Disease	dermatomyositis (is_implicated_in)	PMS1 STAT4	3.47e-05	3	101	2	DOID:10223 (is_implicated_in)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13B	3.47e-05	3	101	2	DOID:0111590 (implicated_via_orthology)
Disease	mean corpuscular hemoglobin concentration	PPP1R21 DNAJC13 IQGAP2 KALRN LRSAM1 CASP10 GCH1 ITPR2 FOCAD BBS7 FBXO7 CMAHP VPS13B	1.02e-04	1105	101	13	EFO_0004528
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	VARS2 ROBO1	2.41e-04	7	101	2	DOID:0060475 (implicated_via_orthology)
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	7.49e-04	12	101	2	DOID:1441 (implicated_via_orthology)
Disease	Influenza	IFIT2 TDRD7 HERC6	7.62e-04	52	101	3	C0021400
Disease	Rolandic epilepsy	KALRN CHRNB4	1.35e-03	16	101	2	Orphanet_1945
Disease	response to phenylephrine	IQGAP2 NEK11	1.53e-03	17	101	2	EFO_0010152
Disease	Liver carcinoma	IQGAP2 DCN STAT4 IGFALS PPP4R3C ROBO1 KIF2C	1.82e-03	507	101	7	C2239176
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	KBTBD8 ITPR1	1.91e-03	19	101	2	EFO_0008582
Disease	response to ziprasidone	GCNT4 PPP3CA	2.12e-03	20	101	2	GO_0097337
Disease	rheumatoid arthritis, ulcerative colitis	STAT4 SNAPC4	2.33e-03	21	101	2	EFO_0000685, EFO_0000729
Disease	red blood cell density measurement	PPP1R21 KALRN NUP205 FARP2 FOCAD SEMA3D VAC14 FBXO7 VPS13B	3.25e-03	880	101	9	EFO_0007978

Protein segments in the cluster

Peptide	Gene	Start	Entry
FIIKRKPLFYTINLI	CHRNB4	226	P30926
LKLIHPKLEYQLLLA	BBS7	606	Q8IWZ6
LYNQPDCLKLLLKGR	ASAP3	631	Q8TDY4
SLVAFPKLKRQVLLY	CUL5	636	Q93034
LPRLQKLYLDRNLIA	IGFALS	241	P35858
LNLKKSPVLQYLFFL	AMPD1	596	P23109
KALKLLNRIFPYNLI	ADCY10	1156	Q96PN6
LLKALRKLDNYLNSP	CLIC6	596	Q96NY7
AKGLLQYLAAVKRLP	AGTPBP1	996	Q9UPW5
AKVRKQLRLKPFYLV	CGAS	346	Q8N884
LVKLQILNLGAKLYL	AP3B1	531	O00203
IKLNPRLAILYAKRA	ST13P5	141	Q8NFI4
IKLNPRLAILYAKRA	ST13	141	P50502
YLKNVLLQFIFLKPG	RGPD5	1711	Q99666
YLKNVLLQFIFLKPG	RGPD8	1711	O14715
KKLRTPLNYILLNLA	RHO	66	P08100
YLTVNKRLPALLEKN	ITPR2	131	Q14571
QLLPLAYNLLKRNLF	HPF1	311	Q9NWY4
NLALYLLGFELKKPV	NUP205	1001	Q92621
LLNPLIYSLRNKDVK	OR5D16	286	Q8NGK9
LPQLKSYLRQKLQAL	FASTK	526	Q14296
LAPLYKVRFPKVQLQ	MTX3	206	Q5HYI7
LYLANNKLTLAPRFL	PODN	151	Q7Z5L7
LVQFLLNKYIRKEPI	MAGEB17	116	A8MXT2
ARFLLLKYQVKQPIT	MAGEC1	916	O60732
LVQFLLLKYQAKEPL	MAGEC3	191	Q8TD91
NLLYTSKRPNAILKL	MAPKAPK2	191	P49137
GQLLPLAYNLLKRNL	nan	311	A8MVJ9
LKKQCLQQLLFLYPE	KIAA0825	191	Q8IV33
YLTVNKRLPALLEKN	ITPR1	131	Q14643
QYQRLLNQKPLSLKL	LRSAM1	551	Q6UWE0
KYFLPLQKLLLPSLQ	DOP1B	131	Q9Y3R5
LERLYLSKNQLKELP	DCN	131	P07585
LPKLNNLYLRLQELV	RASGRP4	376	Q8TDF6
NLPFPLALYKKLLDQ	HERC6	776	Q8IVU3
LIKPIQRITKYQLLL	KALRN	2056	O60229
PKTLIARRYVLQQKL	NEK11	21	Q8NG66
LLQQKLKYQPLKRSL	KIF24	776	Q5T7B8
LLLANPQKEKVRLRY	GGA1	596	Q9UJY5
YKLLSPKQPLLRAQL	POMGNT2	206	Q8NAT1
CFLRKILPYQLKSLE	PPP1R21	351	Q6ZMI0
INPYLKLVLFQNKLH	KBTBD8	521	Q8NFY9
YRLLLPRIKNKSKLQ	GRIN3A	956	Q8TCU5
LKNEAYIPKLLQLFH	PPP4R3C	166	Q6ZMV5
YLIRALPLIKSQLNK	DCHS2	2936	Q6V1P9
KYLKLPVSDVLRQLF	LPCAT2	386	Q7L5N7
ILRKFHYLLNPKQVF	DGKG	451	P49619
NQYGNPLLLFKRLLL	HYDIN	3486	Q4G0P3
LLNVRRLFPQKDIYL	GCNT4	31	Q9P109
ARKQLVPLLYKQFVP	DHH	36	O43323
LQKLSRLFKDQLVYP	FBXO7	301	Q9Y3I1
VLKSLRYLVPLQSKN	FUT10	191	Q6P4F1
RQKLPVFKLRNHILY	DHX35	51	Q9H5Z1
LSKLPLYGLLQAKLQ	AVL9	121	Q8NBF6
AQALKADLVPYLLKL	DNAJC13	2126	O75165
NPLAFKPLKSLAYLR	ECM2	456	O94769
LAYLRLGKNKFRIIP	ECM2	466	O94769
PDNQYLKVLLALKLH	IFIT2	206	P09913
FQPKLAAYRQLPVLK	DNAI4	416	Q5VTH9
PFFLAELLYIIRQKK	CASP10	76	Q92851
KRAKLLARYIPLIQG	DIP2A	41	Q14689
LPLIKSYLFQLLQGL	CDK2	101	P24941
YKRKVLPLRLQNRLF	FAM221A	41	A4D161
LQKVCYLPLNTFLLK	FARP2	666	O94887
LKLFPLYVLALLKQK	SEC24B	1071	O95487
VFLLKNQPCYRKLGL	KIF2C	381	Q99661
LRLFKNLPVRKQFYS	PMS1	146	P54277
LKILYPKTLFLLRGN	PPP3CA	136	Q08209
YAKLRLALLKVLLQP	FOCAD	191	Q5VW36
LVATLRYKKLRQPLN	OPN1SW	56	P03999
LPLLAARRYKLQKQL	VARS2	996	Q5ST30
RLQLLDVKNNPYLIK	VAC14	681	Q08AM6
AIKLNPRLAILYAKR	ST13P4	136	Q8IZP2
FPRQYFALRKILKQL	TRIM39	321	Q9HCM9
LILKLRYFTPKEIAN	TRDMT1	336	O14717
NFLKRFQLTKLPPYL	USP39	436	Q53GS9
KNREKYLLPFLSLQI	LAPTM5	86	Q13571
LLQTNPLYLAKLIFQ	IQGAP2	891	Q13576
YLPNKQVLGLSKLAR	GCH1	156	P30793
RPLNAKKLYLSSNLI	SLITRK3	406	O94933
LLLYPAKRKQLLRSE	TDRD7	296	Q8NHU6
ALIAIRYLSKLKPQL	MROH2B	806	Q7Z745
NIPRLKLTYKDLLLS	SEMA3D	41	O95025
FERYLLSQKPKCLLQ	ADAMDEC1	396	O15204
LNYKARLVKNLQPRI	CMAHP	236	Q9Y471
IFHLLKNFLRLLPKF	NCAPD3	216	P42695
PNNILKLRNLDLLIY	RPP38-DT	86	Q8N326
QLLIDLFKYLAPFLR	CNOT1	2066	A5YKK6
EQYFPVLKRKANLLR	FYTTD1	131	Q96QD9
QRLTKYPLLLKSVLR	PLEKHG5	486	O94827
NLPSYFRLQKPLLIL	TXNDC16	621	Q9P2K2
FLIAQLPKLQYNKNL	WASHC5	1046	Q12768
LKNKRNPRLVPYALL	RYR3	1011	Q15413
TVKLRLLIKLPELNY	STAT4	341	Q14765
QILPTIYKRKNLSLF	TMTC2	211	Q8N394
QLLKTLRYNFLPEAL	NUP188	1406	Q5SRE5
KRQRLPLALQNLFLY	SLC35A4	211	Q96G79
LLARILQKNYPYIAK	SRRD	256	Q9UH36
KVLDLRINLKPSYLV	VPS13C	686	Q709C8
IKGLKPNAIYLFLVR	ROBO1	621	Q9Y6N7
KRLLLPYIVLNKACL	TIMM21	21	Q9BVV7
RYIKNLKPSDLQLSL	VPS13B	16	Q7Z7G8
VRQNLLLKYGKPLQL	ZZEF1	516	O43149
LQRLLQPKLLKLEYL	SNAPC4	201	Q5SXM2
PILNRLAKIFYFLGK	TTC22	296	Q5TAA0
FDRKRLQYLEKLNLP	SLFN5	176	Q08AF3
YRQPLNVYCLLDKKL	TRIM59	101	Q8IWR1
QGLLLPQDKKEYRLF	TTF2	61	Q9UNY4
KLIFLKVNLPLIYFQ	ZBED4	1156	O75132