Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

6.34e-0814123614GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

GBX1 HOXB5 HOXC8 NKX6-1 HOXD4 GSC2 LEUTX NOBOX NKX1-2 MEOX2

1.84e-0414593610GO:0000977
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO1 ANO9

5.88e-0420362GO:0005229
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO1 ANO9

5.88e-0420362GO:0141147
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO1 ANO9

7.81e-0423362GO:0017128
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

HOXB5 NKX6-1 HOXD4 GSC2 LEUTX NOBOX NKX1-2 MEOX2

1.40e-031244368GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

HOXB5 NKX6-1 HOXD4 GSC2 LEUTX NOBOX NKX1-2 MEOX2

1.61e-031271368GO:0000987
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO1 ANO9

3.67e-0350362GO:0099095
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO1 ANO9

3.81e-0351362GO:0140303
GeneOntologyCellularComponentchromatin

HLX DDX23 GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

7.06e-0914803615GO:0000785
MousePhenoabnormal dorsal root ganglion morphology

CACNA1S GBX1 UNCX PDPK1

5.95e-05104294MP:0000961
MousePhenocervical vertebral transformation

HOXB5 HOXC8 HOXD4

8.12e-0541293MP:0004615
MousePhenoabnormal cervical vertebrae morphology

CACNA1S HOXB5 HOXC8 HOXD4

1.04e-04120294MP:0003048
DomainHomeobox

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

4.72e-182343614PF00046
DomainHOMEOBOX_1

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

5.33e-182363614PS00027
DomainHomeobox_dom

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

6.37e-182393614IPR001356
DomainHOMEOBOX_2

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

6.37e-182393614PS50071
DomainHomeobox_CS

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NKX1-2 MEOX2

1.17e-171863613IPR017970
Domain-

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

6.87e-1728336141.10.10.60
DomainHOX

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 NOBOX NKX1-2 MEOX2

2.84e-162373613SM00389
DomainHomeodomain-like

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX NKX1-2 MEOX2

6.39e-163323614IPR009057
DomainHomeobox_metazoa

HLX GBX1 HOXB5 HOXC8 NKX6-1 HOXD4 DBX2 DBX1 NKX1-2 MEOX2

9.25e-16903610IPR020479
DomainHTH_motif

HLX HOXC8 NKX6-1 DBX2 DBX1

2.05e-0769365IPR000047
DomainHomeobox_Antennapedia_CS

HOXB5 HOXC8 HOXD4

8.54e-0621363IPR001827
DomainANTENNAPEDIA

HOXB5 HOXC8 HOXD4

1.29e-0524363PS00032
DomainAnoctamin

ANO1 ANO9

1.61e-0410362PF04547
DomainAnoctamin

ANO1 ANO9

1.61e-0410362IPR007632
DomainHomeobox_antennapedia

HOXB5 HOXD4

2.36e-0412362IPR017995
Pubmed

A census of human transcription factors: function, expression and evolution.

HLX GBX1 HOXB5 HOXC8 NKX6-1 UNCX HOXD4 DBX2 DBX1 GSC2 LEUTX NOBOX MEOX2

3.19e-12908361319274049
Pubmed

Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.

AKTIP NKX6-1 DBX2 DBX1

6.98e-092236415789444
Pubmed

Detection of homeobox genes in development and evolution.

HLX GBX1 DBX1

8.52e-0893631720547
Pubmed

ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling.

NKX6-1 DBX2 DBX1

2.23e-071236331336385
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

HOXB5 HOXC8 HOXD4 GSC2 NKX1-2 MEOX2

2.84e-0726336620932939
Pubmed

A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton.

HOXB5 HOXC8 HOXD4

2.89e-07133638625838
Pubmed

The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.

HOXB5 HOXC8 HOXD4

2.89e-07133638887324
Pubmed

Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits.

NKX6-1 DBX1 GSC2

4.59e-071536330593496
Pubmed

Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.

NKX6-1 DBX2 DBX1

5.65e-071636319258013
Pubmed

Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain.

NKX6-1 HOXD4 DBX1

5.65e-071636317026983
Pubmed

Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.

NKX6-1 DBX1 NKX1-2

6.86e-071736318003640
Pubmed

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.

NKX6-1 DBX2 DBX1

8.22e-071836312874134
Pubmed

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.

NKX6-1 DBX2 DBX1

9.76e-071936311567614
Pubmed

Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis.

HOXB5 HOXC8

1.04e-0623622458220
Pubmed

Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice.

HOXC8 HOXD4

1.04e-06236220126390
Pubmed

Region-specific expression of two mouse homeo box genes.

HOXB5 HOXC8

1.04e-0623622881353
Pubmed

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.

HOXB5 HOXC8 HOXD4

1.15e-062036312370779
Pubmed

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

HOXB5 UNCX HOXD4

1.34e-062136330254164
Pubmed

Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms.

NKX6-1 DBX2 DBX1

1.34e-062136317321515
Pubmed

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord.

NKX6-1 DBX2 DBX1

1.55e-062236315215207
Pubmed

Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning.

NKX6-1 DBX2 DBX1

1.55e-062236331291587
Pubmed

Organization of human class I homeobox genes.

HOXB5 HOXC8 HOXD4

1.55e-06223632576652
Pubmed

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.

NKX6-1 DBX2 DBX1

1.55e-062236312435629
Pubmed

Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos.

NKX6-1 DBX1 NKX1-2

2.03e-062436331235634
Pubmed

Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.

HOXB5 HOXC8 HOXD4

2.03e-06243639367423
Pubmed

Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.

NKX6-1 DBX2 DBX1

2.03e-062436314534138
Pubmed

Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.

NKX6-1 DBX2 DBX1

2.60e-062636323827310
Pubmed

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.

NKX6-1 DBX2 DBX1

2.93e-062736320081190
Pubmed

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.

NKX6-1 DBX2 DBX1

2.93e-062736315075292
Pubmed

Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism.

CACNA1S MEOX2

3.12e-06336226245899
Pubmed

Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.

NKX6-1 DBX2 DBX1

3.65e-062936330177510
Pubmed

Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.

HOXB5 NKX6-1 HOXD4

3.65e-062936323843306
Pubmed

A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation.

UNCX NKX1-2 MEOX2

4.06e-063036332597756
Pubmed

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.

NKX6-1 DBX2 DBX1

4.49e-063136319592574
Pubmed

Sf3b4 regulates chromatin remodeler splicing and Hox expression.

HOXB5 HOXC8 HOXD4

4.95e-063236337167859
Pubmed

Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse.

DBX2 DBX1

6.24e-0643628798145
Pubmed

Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4.

HLX MEOX2

6.24e-0643629073066
Pubmed

CFTR and TMEM16A are separate but functionally related Cl- channels.

ANO1 ANO9

6.24e-06436222178883
Pubmed

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.

HOXB5 HOXD4

6.24e-0643627628700
Pubmed

Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns.

HOXB5 HOXD4

6.24e-0643629106661
Pubmed

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

HOXB5 HOXC8 NKX6-1 HOXD4

6.82e-0611836416971476
Pubmed

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling.

NKX6-1 DBX2 DBX1

8.38e-063836325936505
Pubmed

Atlas of Hox gene expression in the developing kidney.

HOXB5 HOXC8 HOXD4

8.38e-063836315042701
Pubmed

Complete mutation analysis panel of the 39 human HOX genes.

HOXB5 HOXC8 HOXD4

8.38e-063836311857506
Pubmed

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.

HOXB5 HOXC8 HOXD4

9.07e-063936333257809
Pubmed

Quantification of Hox and surfactant protein-B transcription during murine lung development.

HOXB5 HOXC8 HOXD4

9.80e-064036319204410
Pubmed

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.

HLX GBX1 NKX6-1 DBX1

1.00e-0513036419386638
Pubmed

Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.

NKX6-1 DBX1

1.04e-05536226443638
Pubmed

Cloning and characterization of four murine homeobox genes.

UNCX NOBOX

1.04e-0553628855241
Pubmed

Comprehensive comparative homeobox gene annotation in human and mouse.

GBX1 NOBOX

1.04e-05536226412852
Pubmed

Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.

HOXB5 HOXC8 HOXD4

1.06e-054136332479258
Pubmed

Reduction of Hox gene expression by histone H1 depletion.

HOXB5 HOXC8 HOXD4

1.22e-054336322701719
Pubmed

Nomenclature for human homeobox genes.

HOXB5 HOXC8 HOXD4

1.31e-05443631973146
Pubmed

Gata2 specifies serotonergic neurons downstream of sonic hedgehog.

DBX2 DBX1

1.56e-05636214973276
Pubmed

A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord.

DBX2 DBX1

1.56e-05636210399918
Pubmed

cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles.

GBX1 NOBOX

1.56e-05636216597639
Pubmed

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.

HOXD4 NKX1-2

1.56e-0563629748262
Pubmed

Vertebrate homeobox gene nomenclature.

HOXB5 HOXC8 HOXD4

1.60e-05473631358459
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

HOXB5 HOXC8 UNCX HOXD4 GSC2 MEOX2

1.86e-0554436628473536
Pubmed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.

HOXB5 HOXC8 HOXD4

1.93e-055036328188179
Pubmed

Sequence and embryonic expression of the murine Hox-3.5 gene.

HOXC8 HOXD4

2.18e-0573621363091
Pubmed

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.

AKTIP PDPK1

2.18e-05736214749367
Pubmed

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos.

HOXB5 HOXD4

2.18e-0573629694798
Pubmed

Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll.

HOXC8 HOXD4

2.18e-05736216618927
Pubmed

Expression of TMEM16 paralogs during murine embryogenesis.

ANO1 ANO9

2.91e-05836218729231
Pubmed

Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network.

HOXB5 HOXC8

2.91e-0583621976088
Pubmed

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.

ANO1 ANO9

2.91e-05836221984732
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO1 ANO9

2.91e-05836222946059
Pubmed

Hox genes regulate the onset of Tbx5 expression in the forelimb.

HOXB5 HOXD4

2.91e-05836222872086
Pubmed

New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis.

HOXB5 HOXD4

2.91e-0583622890503
Pubmed

Expression and function of epithelial anoctamins.

ANO1 ANO9

2.91e-05836220056604
Pubmed

Genetic interactions and dosage effects of Polycomb group genes in mice.

HOXC8 HOXD4

2.91e-0583629716520
Pubmed

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.

HOXC8 UNCX

2.91e-05836227187787
Pubmed

Transcriptional analyses of two mouse models of spina bifida.

NKX6-1 DBX1

3.73e-05936223024056
Pubmed

Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation.

NKX6-1 UNCX

3.73e-05936215652703
Pubmed

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.

HOXC8 HOXD4

3.73e-0593629043087
Pubmed

The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development.

HOXB5 HOXC8

3.73e-0593621685115
Pubmed

Region-specific gastrointestinal Hox code during murine embryonal gut development.

HOXB5 HOXD4

3.73e-05936211869294
Pubmed

Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.

HOXB5 HOXD4

3.73e-05936210579975
Pubmed

Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton.

UNCX MEOX2

4.66e-051036220236942
Pubmed

Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO1 ANO9

4.66e-051036219015192
Pubmed

Distal-less and other homeobox genes in the development of the dentition.

DBX1 MEOX2

4.66e-05103627964557
Pubmed

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.

ANO1 ANO9

4.66e-051036223532839
Pubmed

Structure and function of TMEM16 proteins (anoctamins).

ANO1 ANO9

4.66e-051036224692353
Pubmed

Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.

NKX6-1 DBX2

5.70e-051136223288605
Pubmed

Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms.

NKX6-1 UNCX

5.70e-051136218061569
Pubmed

Homeobox genes: a link between development, cell cycle, and cancer?

HOXB5 HOXD4

5.70e-051136210328847
Pubmed

Cognate homeo-box loci mapped on homologous human and mouse chromosomes.

HOXB5 HOXC8

5.70e-05113622878432
Pubmed

Expression of class I homeobox genes in fetal and adult murine skin.

HOXB5 HOXD4

6.83e-05123628105001
Pubmed

Specification of vertebral identity is coupled to Notch signalling and the segmentation clock.

HOXC8 UNCX

6.83e-051236214960495
Pubmed

TMED2 binding restricts SMO to the ER and Golgi compartments.

NKX6-1 DBX1

6.83e-051236235353806
Pubmed

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling.

NKX6-1 DBX2

6.83e-051236215629701
Pubmed

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.

UNCX MEOX2

8.07e-051336226237517
Pubmed

Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.

HOXC8 HOXD4

8.07e-051336217586487
Pubmed

A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling.

NKX6-1 DBX1

9.41e-051436219776033
Pubmed

Organization and expression of mouse Hox3 cluster genes.

HOXB5 HOXC8

9.41e-05143628099712
Pubmed

Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve.

NKX6-1 DBX2

9.41e-051436212571110
Pubmed

Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis.

NKX6-1 DBX1

9.41e-051436225721514
Pubmed

Hox-1.11 and Hox-4.9 homeobox genes.

HOXB5 HOXD4

9.41e-05143621348361
Pubmed

Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2.

DBX2 DBX1

9.41e-051436218701439
GeneFamilyHOXL subclass homeoboxes

GBX1 HOXB5 HOXC8 HOXD4 MEOX2

2.18e-0852305518
GeneFamilyNKL subclass homeoboxes and pseudogenes

HLX NKX6-1 DBX2 DBX1 NKX1-2

7.96e-0867305519
GeneFamilyPRD class homeoboxes and pseudogenes

UNCX GSC2 LEUTX NOBOX

1.55e-0592304521
GeneFamilyAnoctamins

ANO1 ANO9

1.19e-0410302865
CoexpressionMIKKELSEN_IPS_WITH_HCP_H3K27ME3

HOXB5 HOXC8 UNCX HOXD4 DBX1

2.91e-07103365M1967
CoexpressionMIKKELSEN_IPS_WITH_HCP_H3K27ME3

HOXB5 HOXC8 UNCX HOXD4 DBX1

3.36e-07106365MM1265
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

GBX1 HOXB5 HOXC8 NKX6-1 UNCX DBX1

1.77e-06272366M1938
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

GBX1 HOXB5 HOXC8 NKX6-1 UNCX DBX1

2.18e-06282366MM822
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K27ME3

HOXB5 HOXC8 NKX6-1 UNCX DBX1

1.03e-04345365M2009
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K27ME3

HOXB5 HOXC8 NKX6-1 UNCX DBX1

1.06e-04347365MM860
CoexpressionTAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP

HLX MTCL1 PRSS23 RHOBTB1

1.14e-04183364M6670
CoexpressionGSE16450_CTRL_VS_IFNA_12H_STIM_MATURE_NEURON_CELL_LINE_UP

SFI1 NKX6-1 HOXD4 MEOX2

1.60e-04200364M7411
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_1000

ANO1 TXNDC16 HOXB5 AKTIP HOXC8 PRSS23 UNCX POLE MEOX2

2.49e-06749359gudmap_kidney_P3_CapMes_Crym_1000
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX HOXD4 POLE MEOX2

7.31e-06291356gudmap_kidney_P2_CapMes_Crym_500
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_200

ANO1 HOXB5 HOXC8 PRSS23 UNCX

7.38e-06166355gudmap_kidney_P3_CapMes_Crym_200
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_500

ANO1 HOXB5 AKTIP HOXC8 PRSS23 UNCX

2.85e-05370356gudmap_kidney_P3_CapMes_Crym_500
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#1_top-relative-expression-ranked_1000

TXNDC16 HOXB5 HOXC8 UNCX MEOX2

4.02e-05236355gudmap_kidney_P3_CapMes_Crym_k1_1000
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_1000

TXNDC16 HOXB5 HOXC8 UNCX HOXD4 POLE MEOX2

6.78e-05636357gudmap_kidney_P2_CapMes_Crym_1000
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_k-means-cluster#2_top-relative-expression-ranked_100

ANO1 PRSS23

7.34e-058352gudmap_kidney_P4_CapMesRenVes_Crym_k2_100
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_200

HOXB5 HOXC8 UNCX MEOX2

7.86e-05139354gudmap_kidney_P2_CapMes_Crym_200
CoexpressionAtlaskidney_P1_CapMes_Crym_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX HOXD4 MEOX2

8.44e-05276355gudmap_kidney_P1_CapMes_Crym_500
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_500

ANO1 AKTIP PRSS23

1.13e-0457353gudmap_kidney_P3_CapMes_Crym_k4_500
CoexpressionAtlaskidney_P0_CapMes_Crym_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX HOXD4 MEOX2

1.14e-04294355gudmap_kidney_P0_CapMes_Crym_500
CoexpressionAtlaskidney_P0_CapMes_Crym_top-relative-expression-ranked_100

HOXB5 HOXC8 MEOX2

1.52e-0463353gudmap_kidney_P0_CapMes_Crym_100
CoexpressionAtlaskidney_P2_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_1000

TXNDC16 HOXC8 MEOX2

1.75e-0466353gudmap_kidney_P2_CapMes_Crym_k3_1000
CoexpressionAtlasgudmap_RNAseq_e15.5_Mesangium_2500_K0

HOXB5 UNCX HOXD4

1.83e-0467353gudmap_RNAseq_e15.5_Mesangium_2500_K0
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_1000

ANO1 HOXB5 HOXC8 PRSS23 UNCX HOXD4 POLE

2.46e-04783357gudmap_kidney_P4_CapMesRenVes_Crym_1000
CoexpressionAtlaskidney_P1_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_1000

TXNDC16 HOXC8 MEOX2

2.55e-0475353gudmap_kidney_P1_CapMes_Crym_k3_1000
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_100

HOXC8 UNCX MEOX2

2.87e-0478353gudmap_developingKidney_e15.5_Cap mesenchyme_100
CoexpressionAtlaskidney_P2_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_500

HOXB5 UNCX HOXD4 POLE

3.30e-04202354gudmap_kidney_P2_CapMes_Crym_k3_500
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

ANO1 PRSS23

3.53e-0417352gudmap_kidney_P4_CapMesRenVes_Crym_k4_200
CoexpressionAtlaskidney_P2_CapMes_Crym_top-relative-expression-ranked_100

HOXB5 HOXC8 MEOX2

3.57e-0484353gudmap_kidney_P2_CapMes_Crym_100
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_100

HOXB5 UNCX MEOX2

3.69e-0485353gudmap_developingKidney_e11.5_metaneph mesench_100
CoexpressionAtlaskidney_P0_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_1000

TXNDC16 HOXC8 MEOX2

3.69e-0485353gudmap_kidney_P0_CapMes_Crym_k2_1000
CoexpressionAtlaskidney_P2_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

HOXC8 MEOX2

3.97e-0418352gudmap_kidney_P2_CapMes_Crym_k4_200
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#2_top-relative-expression-ranked_1000

HOXC8 UNCX MEOX2

4.23e-0489353gudmap_developingKidney_e11.5_metaneph mesench_1000_k2
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_100

HOXB5 HOXC8 UNCX

4.23e-0489353gudmap_kidney_P3_CapMes_Crym_100
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_100

ANO1 HOXB5 PRSS23

4.23e-0489353gudmap_kidney_P4_CapMesRenVes_Crym_100
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

ANO1 HOXB5 HOXC8 PRSS23 UNCX

4.61e-04398355gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX CDK12 MEOX2

4.77e-04401355gudmap_developingKidney_e15.5_Cap mesenchyme_500
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_k-means-cluster#4_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX

5.12e-0495353gudmap_kidney_P4_CapMesRenVes_Crym_k4_500
CoexpressionAtlaskidney_P1_CapMes_Crym_top-relative-expression-ranked_1000

TXNDC16 HOXB5 HOXC8 UNCX HOXD4 MEOX2

5.32e-04633356gudmap_kidney_P1_CapMes_Crym_1000
CoexpressionAtlaskidney_P0_CapMes_Crym_top-relative-expression-ranked_1000

TXNDC16 HOXB5 HOXC8 UNCX HOXD4 MEOX2

5.59e-04639356gudmap_kidney_P0_CapMes_Crym_1000
CoexpressionAtlasgudmap_RNAseq_p2_CD2APMEISWT_2500_K2

HOXB5 PRSS23 HOXD4

5.77e-0499353gudmap_RNAseq_p2_CD2APMEISWT_2500_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#5

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

6.52e-04658356Facebase_RNAseq_ratio_e10.5_MandibularArch_vs_MaxillaryArch_2500_K5
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_200

ANO1 PRSS23

6.53e-0423352gudmap_kidney_P3_CapMes_Crym_k2_200
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#5_top-relative-expression-ranked_500

PRSS23 UNCX LARS2

6.85e-04105353gudmap_developingKidney_e14.5 whole kidney - wildtype_500_k5
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#4_top-relative-expression-ranked_100

UNCX MEOX2

7.12e-0424352gudmap_developingKidney_e11.5_metaneph mesench_100_k4
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#3_top-relative-expression-ranked_100

UNCX MEOX2

7.12e-0424352gudmap_developingKidney_e15.5_Cap mesenchyme_100_k3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#5

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

8.24e-04688356Facebase_RNAseq_e10.5_Mandibular Arch_2500_K5
CoexpressionAtlaskidney_P1_CapMes_Crym_top-relative-expression-ranked_200

HOXB5 HOXC8 MEOX2

1.01e-03120353gudmap_kidney_P1_CapMes_Crym_200
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#5

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

1.06e-03722356Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K5
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#3_top-relative-expression-ranked_500

HOXB5 HOXC8 UNCX

1.08e-03123353gudmap_kidney_P3_CapMes_Crym_k3_500
CoexpressionAtlaskidney_P0_CapMes_Crym_top-relative-expression-ranked_200

HOXB5 HOXC8 MEOX2

1.11e-03124353gudmap_kidney_P0_CapMes_Crym_200
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

1.12e-03730356Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#4_top-relative-expression-ranked_1000

ANO1 CDK12 PDPK1

1.19e-03127353gudmap_developingGonad_e16.5_epididymis_1000_k4
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500

ANO1 HOXC8 PRSS23 LARS2 MANEAL

1.21e-03493355Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
CoexpressionAtlasFacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

1.23e-03743356Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

1.26e-03747356Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#2

ANO1 AKTIP HOXC8 PRSS23 LARS2 MANEAL

1.26e-03747356Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_2500_K2
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500

HLX HOXB5 HOXC8 UNCX HOXD4

1.26e-03498355PCBC_ratio_EB_vs_SC_500
CoexpressionAtlaskidney_adult_RenalCapsule_k-means-cluster#1_top-relative-expression-ranked_1000

HOXC8 MEOX2

1.27e-0332352gudmap_kidney_adult_RenalCapsule_k1_1000
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#3_top-relative-expression-ranked_200

PRSS23 LARS2

1.27e-0332352gudmap_developingKidney_e14.5 whole kidney - wildtype_200_k3
CoexpressionAtlasEmbryoid Body Cells-method_mRNA_vs_Embryoid Body Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

HOXB5 UNCX HOXD4 MANEAL

1.33e-03293354PCBC_ratio_EB_from-mRNA_vs_EB_from-ESC_cfr-2X-p05
CoexpressionAtlasEmbryoid Body Cells-reprogram_OSKM-L_vs_Embryoid Body Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

HOXB5 UNCX HOXD4 MANEAL

1.33e-03293354PCBC_ratio_EB_from-OSKM-L_vs_EB_from-ESC_cfr-2X-p05
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_100

HOXB5 HOXC8

1.35e-0333352gudmap_kidney_P3_CapMes_Crym_k2_100
CoexpressionAtlasepididymis

ANO1 HOXB5 HOXC8 HOXD4

1.38e-03296354epididymis
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#2_top-relative-expression-ranked_200

UNCX MEOX2

1.43e-0334352gudmap_developingKidney_e11.5_metaneph mesench_200_k2
CoexpressionAtlaskidney_P2_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_500

HOXC8 MEOX2

1.43e-0334352gudmap_kidney_P2_CapMes_Crym_k2_500
CoexpressionAtlasgudmap_RNAseq_e11.5_Ureteric_tips_2500_K2

HLX HOXB5 PRSS23 UNCX

1.52e-03304354gudmap_RNAseq_e11.5_Ureteric_tips_2500_K2
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

ANO1 HOXC8 HOXD4 POLE DSE TBC1D2B

1.54e-03777356gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000

HOXB5 HOXC8 UNCX CDK12 POLE MEOX2

1.56e-03779356gudmap_developingKidney_e15.5_Cap mesenchyme_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_OlfacPit_2500_K4

UNCX MEOX2

1.98e-0340352facebase_RNAseq_e10.5_OlfacPit_2500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_OlfacPit_2500

ANO1 ANO9 AKTIP MTCL1 HOXC8 UNCX LARS2 MEOX2

2.10e-031453358facebase_RNAseq_e10.5_OlfacPit_2500
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ANO1 HOXC8 NKX6-1 TLCD5 MEOX2

5.56e-0720036507641f476cb1a131c2a50258b88cc13bb38c8379
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ANO1 HOXC8 NKX6-1 TLCD5 MEOX2

5.56e-07200365343fa6ba1f52d816d2e41466f674ff8360aecd81
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ANO1 HOXC8 NKX6-1 TLCD5 MEOX2

5.56e-07200365d0c00cdd52c2e001aec9b935f4e981ba77d0386a
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HLX BTNL8 TLCD5 MEOX2

8.10e-06159364b05fda31b77536a1878f55d3199563b53f9420b2
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

HLX BTNL8 TLCD5 MEOX2

8.10e-06159364ae53ab7a1339007d0b245c6c291ac61e5ff5b682
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLX PRSS23 DNAH6 MEOX2

1.53e-051873643548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLX PRSS23 DNAH6 MEOX2

1.53e-05187364f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HLX PRSS23 DNAH6 MEOX2

1.53e-0518736481754e965848b718be20ee97ce072ce426938a69
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)|Striatum / BrainAtlas - Mouse McCarroll V32

HOXC8 GSC2 NOBOX

3.18e-05763633073a8ace46ad18bddd22ec8f3a1b59ee2fd989d
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)-|Striatum / BrainAtlas - Mouse McCarroll V32

HOXC8 GSC2 NOBOX

3.18e-05763633f5865b9cb6648b88eb873018e513c5efb457ae5
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat|Striatum / BrainAtlas - Mouse McCarroll V32

HOXC8 GSC2 NOBOX

3.18e-0576363041a8984b3ae4bb03ae6db8234c1333ac73098fa
Diseasecreatinine measurement, glomerular filtration rate

CACNA1S UNCX CDK12

3.94e-04117363EFO_0004518, EFO_0005208
Diseasetriglyceride change measurement, response to simvastatin, response to fenofibrate

AKTIP RHOBTB1

9.38e-0437362EFO_0007681, GO_1901557, GO_1903491
Diseaseforced expiratory volume

HLX MTCL1 PRSS23 LARS2 CDK12

2.56e-03789365EFO_0004314
Diseasecolorectal cancer, hormone replacement therapy

HLX BTNL8

5.19e-0388362EFO_0003961, MONDO_0005575
Diseasenevus count, cutaneous melanoma

ANO9 TASOR2

5.54e-0391362EFO_0000389, EFO_0004632
DiseaseAdenocarcinoma of large intestine

CDK12 POLE

6.14e-0396362C1319315
Diseaselower face morphology measurement

HLX PRSS23

7.85e-03109362EFO_0010948
Diseasecutaneous melanoma

TASOR2 TLCD5

9.59e-03121362EFO_0000389

Protein segments in the cluster

PeptideGeneStartEntry
WQDCHELWSKKRRRQ

CDK12

1036

Q9NYV4
FQWKIQAELDWRRKH

BTNL8

261

Q6UX41
KRAFAKWRRNHNHIW

AKTIP

161

Q9H8T0
KKTWARWRHMFREQP

ANO9

161

A1A5B4
RWQIHHSEKNWNREK

MTCL1

1231

Q9Y4B5
WFQNRRAKWRKMEKL

NOBOX

351

O60393
KVWFQNRRMKWRHSK

HLX

321

Q14774
KIWFQNRRMKWRNSK

DBX1

226

A6NMT0
VHRNKYKDWIKGWRN

DSE

431

Q9UL01
VKVWFQNRRMKWKRV

MEOX2

231

P50222
HWKRKQMRLNYRWDL

ANO1

426

Q5XXA6
WLRFHKKKWQLQARQ

POLE

1271

Q07864
KEAKQRWDDRHWSQK

DDX23

346

Q9BUQ8
WHSIRRQKREWIKFA

DSG1

41

Q02413
RQIKIWFQNRRMKWK

HOXB5

236

P09067
RQIKIWFQNRRMKWK

HOXD4

196

P09016
FRKWKAFSVWRKNVR

DNAH6

276

Q9C0G6
KIWFQNRRAKWKRIK

GBX1

306

Q14549
EVWFKNRRAKWRHQK

GSC2

171

O15499
QWNRIFRWKCHDIVK

CACNA1S

416

Q13698
KIWFQNRRMKWRNSK

DBX2

231

Q6ZNG2
TRRWAEHFIKEKEQW

MANEAL

441

Q5VSG8
RQVKIWFQNRRMKWK

HOXC8

191

P31273
LCRWAQKHKNWRFQK

C7orf50

106

Q9BRJ6
HQHWQKRRFLKAWLE

SFI1

281

A8K8P3
RKDVEKWWHQRIKEQ

LARS2

56

Q15031
QVKIWFQNRRTKWKK

NKX1-2

206

Q9UD57
KVWFQNRRTKWRKKH

NKX6-1

281

P78426
NAHKWCRKIQEVWRQ

PDPK1

531

O15530
YVRMWKRQQQKWERK

PRSS23

321

O95084
ALNKHRSRRKWCFWN

RHOBTB1

676

O94844
WRKSIKKYHAWRSRR

TLCD5

216

Q6ZRR5
RIKHWNRSNWFKEAE

TXNDC16

796

Q9P2K2
NGRWKWLLHYRENKK

TASOR2

2311

Q5VWN6
VWKWCVDRHTRKFKD

TBC1D2B

671

Q9UPU7
VWFQNRRAKWRKKEN

UNCX

151

A6NJT0
VVKIWFKNQRAKWKR

LEUTX

51

A8MZ59