Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainZinc_finger_PHD-type_CS

PHF2 DIDO1

7.70e-0465122IPR019786
DomainPHD

PHF2 DIDO1

1.02e-0375122PF00628
DomainZnf_PHD-finger

PHF2 DIDO1

1.13e-0379122IPR019787
DomainPHD

PHF2 DIDO1

1.44e-0389122SM00249
DomainZnf_PHD

PHF2 DIDO1

1.50e-0391122IPR001965
DomainZF_PHD_2

PHF2 DIDO1

1.63e-0395122PS50016
DomainZF_PHD_1

PHF2 DIDO1

1.67e-0396122PS01359
DomainZnf_FYVE_PHD

PHF2 DIDO1

3.86e-03147122IPR011011
Domain-

PHF2 DIDO1

3.25e-024491223.30.40.10
DomainZnf_RING/FYVE/PHD

PHF2 DIDO1

3.38e-02459122IPR013083
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

NRXN2 MECP2

1.30e-0236772M48346
Pubmed

HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP.

PHF2 MLXIPL

1.29e-06513231227231
Pubmed

High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.

PHF2 MLXIPL

5.21e-052913234461288
Pubmed

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

NRXN2 MLXIPL

2.81e-046713223263486
InteractionPHF2 interactions

PHF2 MECP2 MLXIPL

1.20e-0578123int:PHF2
InteractionNRXN2 interactions

NRXN2 MECP2

2.14e-0512122int:NRXN2
InteractionNLGN1 interactions

NRXN2 GJD3

7.46e-0522122int:NLGN1
GeneFamilyPHD finger proteins

PHF2 DIDO1

3.63e-04906288
CoexpressionGSE20727_H2O2_VS_ROS_INHIBITOR_TREATED_DC_UP

PHF2 MECP2 PRR22

1.17e-04199133M9255
CoexpressionGSE41176_UNSTIM_VS_ANTI_IGM_STIM_TAK1_KO_BCELL_6H_UP

LMOD2 DIDO1 MECP2

1.18e-04200133M9931
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_500_k-means-cluster#4

NRXN2 PHF2 MLXIPL

5.99e-05129133Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_500_K4
ToppCellhuman_hepatoblastoma-Tumor_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

DIDO1 SOBP MLXIPL

2.15e-05193133503a979328c68b096680b71359a26f02fafdff35
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Sln_(Unipolar_brush_cell)|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMOD2 GJD3

3.18e-0492132b867cd7923585b13beaf086c40781bab2d7b7434
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Sln_(Unipolar_brush_cell)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMOD2 GJD3

3.18e-0492132a5b89f971b904b8e280fe66996a7f8efd92c2132
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-4|TCGA-Cervix / Sample_Type by Project: Shred V9

SOBP ZBTB12

6.14e-041281323ca9ae69fb8cb7f8acb7540aa71778bc917da4df
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMOD2 GJD3

6.33e-041301323d81151ee1369d819843826fc6ac197d83255e1d
ToppCellCerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Cerebellum / BrainAtlas - Mouse McCarroll V32

LMOD2 GJD3

6.33e-04130132ab141d91988a5de6d092757377a53f7de3707556
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF2 SOBP

6.52e-041321324152529611eeacf0c547e2a134d5b98c45426b13
ToppCellMild/Remission-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOBP MLXIPL

7.54e-04142132fc5fc2d2b4b976358b8ce762c1f440b20db84103
ToppCellMild/Remission-B_naive-5|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SOBP MLXIPL

8.19e-041481328b60f9843505660b3c9d5c7792976f902be4b94c
ToppCellHealthy_donor-B_cell|World / disease group, cell group and cell class (v2)

SOBP PRR22

8.41e-04150132a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCellHealthy_donor-B_cell|Healthy_donor / disease group, cell group and cell class (v2)

SOBP PRR22

8.63e-041521325768edfde8010324d8594815e73bbfba2c3045f3
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRR22 GJD3

8.97e-041551325fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.00e-031641325e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.00e-03164132f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.00e-031641327a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.00e-031641324cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.02e-031651321890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.02e-03165132347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.02e-03165132507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRXN2 GJD3

1.02e-0316513239a25be081a5d59c7cf107a997d352793d5025fb
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3orf20 MLXIPL

1.04e-03167132b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCelldroplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 C3orf20

1.05e-03168132e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR22 GJD3

1.05e-03168132260c768468dff51888f7a68e5424bb174dbaa759
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRR22 GJD3

1.05e-0316813218d7719a76620d5e5698f9ffd08b4ad4cb7c13f8
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 C3orf20

1.05e-0316813232e0bc0873baa13027241063283ef26d2aab56f5
ToppCell3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

SOBP ZBTB12

1.09e-03171132fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 C3orf20

1.12e-031731324f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOBP C3orf20

1.12e-031731323059325901b1e5e12a1a91183f14267288b2f600
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOBP C3orf20

1.12e-0317313236c8338463ee4cc432f568728d55989360f9a68d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GFY MLXIPL

1.12e-03173132cc2e489b91562a0c6fe863e2f796f4a7d2ca27dd
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 C3orf20

1.12e-031731329bbea566964281f47bf75d665b7d69ba8326e207
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF2 MLXIPL

1.13e-03174132f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN2 SOBP

1.14e-031751327ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCell5'-Adult-LargeIntestine-Mesenchymal-stromal_related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN2 SOBP

1.14e-03175132b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 GJD3

1.15e-03176132460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

NRXN2 DIDO1

1.18e-03178132edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF2 MLXIPL

1.18e-03178132fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GFY MLXIPL

1.21e-031801320c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCellControl-Myeloid-DC1|Control / Condition, Lineage and Cell class

PRR22 ZBTB12

1.22e-031811325a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRXN2 GJD3

1.23e-03182132d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MLXIPL ZBTB12

1.25e-03183132bbf27d2f4369031fadacacd6c432c06b1ec5abdb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOBP MLXIPL

1.29e-031861325784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOBP MLXIPL

1.29e-03186132b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SOBP

1.30e-031871322f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SOBP MLXIPL

1.30e-03187132f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOBP MLXIPL

1.30e-03187132ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOBP MLXIPL

1.30e-031871323ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SOBP

1.30e-03187132e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SOBP

1.30e-0318713224cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN2 SOBP

1.33e-03189132f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellSepsis-ICU-SEP-Myeloid-cDC1|ICU-SEP / Disease, condition lineage and cell class

SOBP PRR22

1.44e-03197132e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Transverse / Region, Cell class and subclass

NRXN2 MLXIPL

1.47e-03199132facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

NRXN2 MLXIPL

1.47e-03199132fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCellTransverse-(6)_Macrophage-(61)_LYVE1_Macrophage|Transverse / shred on region, Cell_type, and subtype

NRXN2 MLXIPL

1.47e-03199132dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

NRXN2 SOBP

1.48e-03200132c92e4fc0442404481fcac623d691dae6215b852d
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

NRXN2 SOBP

1.48e-03200132979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

NRXN2 MECP2

1.48e-03200132c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

NRXN2 SOBP

1.48e-0320013268c90376e2779434e4ad8dc6dd3b44baa700e2f4
ComputationalNeighborhood of RTN1

NRXN2 SOBP

3.40e-045262GNF2_RTN1
ComputationalNeighborhood of NCAM1

PHF2 MECP2

2.01e-0312762GCM_NCAM1
ComputationalNeighborhood of UBE2N

PHF2 MECP2

2.95e-0315462GCM_UBE2N
ComputationalNeighborhood of RAN

PHF2 MECP2

4.73e-0319662GCM_RAN
Diseasephosphatidylcholine measurement

NRXN2 PHF2 MLXIPL

2.35e-04284133EFO_0010226
DiseaseNonorganic psychosis

LMOD2 SOBP

4.13e-0469132C0349204
DiseaseNeurodevelopmental Disorders

PHF2 MECP2

7.49e-0493132C1535926
DiseasePsychotic Disorders

LMOD2 SOBP

8.83e-04101132C0033975
Diseasebitter alcoholic beverage consumption measurement

NRXN2 MLXIPL

1.52e-03133132EFO_0010092
Diseasegout

NRXN2 MLXIPL

3.26e-03196132EFO_0004274
DiseaseAutistic Disorder

NRXN2 MECP2

5.70e-03261132C0004352

Protein segments in the cluster

PeptideGeneStartEntry
PTVPKPPPKPPSPPA

SMPD1

181

P17405
PPPPPPPPLPEKKLI

LMOD2

441

Q6P5Q4
PPPPPPPLLPLLPLL

NRXN2

26

P58401
KQPPPTPPLPPKLPP

GFY

481

I3L273
LKKPLPPPPPAPPRP

C3orf20

91

Q8ND61
PPPPPPLPEPPVLKV

DIDO1

1261

Q9BTC0
KLLPPPPPPPPPPAL

GJD3

236

Q8N144
PKAPVPLLPPLPPPP

MECP2

376

P51608
PKPPKPPKPPRPPKT

PHF2

506

O75151
DPKPRLPPPPVPPPL

MLXIPL

381

Q9NP71
APLPPPPPKENKPPP

PRR22

181

Q8IZ63
PARTPKPAPKPPPPP

ZBTB12

156

Q9Y330
PPPPPPAPPKKLLSP

SOBP

746

A7XYQ1