Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

HSP90AB4P MYO1D MSH2 ACSF2 DNAH7 UBA7 ATP11B KIF19 AACS MYO15A ATP2A1 ATP2A3 ATP5F1B

2.24e-0561410613GO:0140657
GeneOntologyMolecularFunctionIMP dehydrogenase activity

IMPDH1 IMPDH2

2.79e-0521062GO:0003938
GeneOntologyMolecularFunctionneurexin family protein binding

NLGN4Y NLGN3 NLGN4X

7.74e-05161063GO:0042043
GeneOntologyMolecularFunctioncalcium-dependent ATPase activity

ATP2A1 ATP2A3

1.66e-0441062GO:0030899
GeneOntologyBiologicalProcesssynaptic vesicle cycle

STXBP5L NLGN4Y RPH3A NLGN3 TH NLGN4X SLC18A1 RIMS4 CTNNB1 UNC13A

1.08e-0626410610GO:0099504
GeneOntologyBiologicalProcesscourtship behavior

NLGN4Y THRB NLGN4X

4.55e-0671063GO:0007619
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

CELF6 CALB2 TRIO STXBP5L NLGN4Y MINK1 PCDHB10 PCDHB9 BCR RPH3A YTHDF1 NLGN3 TH NLGN4X RIMS4 CTNNB1 UNC13A

5.14e-0693110617GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

CELF6 CALB2 TRIO STXBP5L NLGN4Y MINK1 PCDHB10 PCDHB9 BCR RPH3A YTHDF1 NLGN3 TH NLGN4X RIMS4 CTNNB1 UNC13A

5.14e-0693110617GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

CELF6 CALB2 TRIO STXBP5L NLGN4Y MINK1 PCDHB10 PCDHB9 BCR RPH3A YTHDF1 NLGN3 TH NLGN4X RIMS4 CTNNB1 UNC13A

5.75e-0693910617GO:0099537
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

STXBP5L NLGN4Y RPH3A NLGN3 TH NLGN4X SLC18A1 RIMS4 CTNNB1 UNC13A

6.17e-0632110610GO:0099003
GeneOntologyBiologicalProcessvocalization behavior

CELF6 NLGN4Y NLGN3 NLGN4X

6.47e-06241064GO:0071625
GeneOntologyBiologicalProcesssynaptic signaling

CELF6 CALB2 TRIO STXBP5L NLGN4Y MINK1 PCDHB10 PCDHB9 BCR RPH3A YTHDF1 NLGN3 TH NLGN4X RIMS4 CTNNB1 UNC13A

9.55e-0697610617GO:0099536
GeneOntologyBiologicalProcesspresynaptic membrane assembly

NLGN4Y NLGN3 NLGN4X

1.54e-05101063GO:0097105
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

NLGN4Y NLGN3 NLGN4X

2.11e-05111063GO:0097104
GeneOntologyBiologicalProcesspresynaptic membrane organization

NLGN4Y NLGN3 NLGN4X

3.63e-05131063GO:0097090
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NLGN4Y NLGN3 NLGN4X

7.04e-05161063GO:0007158
GeneOntologyBiologicalProcessgonad morphogenesis

ITGAV LHX9

7.82e-0531062GO:0035262
GeneOntologyBiologicalProcessterritorial aggressive behavior

NLGN4Y NLGN4X

7.82e-0531062GO:0002124
GeneOntologyBiologicalProcessprotein import into mitochondrial matrix

TIMM23B TIMM23 DNAJC15

1.41e-04201063GO:0030150
GeneOntologyBiologicalProcessmale courtship behavior

NLGN4Y NLGN4X

1.56e-0441062GO:0008049
GeneOntologyBiologicalProcessaminergic neurotransmitter loading into synaptic vesicle

TH SLC18A1

1.56e-0441062GO:0015842
GeneOntologyBiologicalProcessmating behavior

NLGN4Y TH THRB NLGN4X

2.11e-04571064GO:0007617
GeneOntologyBiologicalProcesspositive regulation of glutamate receptor signaling pathway

NLGN3 UNC13A

2.59e-0451062GO:1900451
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN4Y NLGN3 NLGN4X

4.91e-0741053GO:0098983
GeneOntologyCellularComponentsymmetric synapse

NLGN4Y NLGN3 NLGN4X

3.40e-05131053GO:0032280
GeneOntologyCellularComponentTIM23 mitochondrial import inner membrane translocase complex

TIMM23B TIMM23 DNAJC15

6.58e-05161053GO:0005744
GeneOntologyCellularComponentdendrite

PCSK5 CALB2 GOPC MYO1D NLGN4Y MINK1 BCR RPH3A WDR47 NLGN3 TH NLGN4X CTNNB1 FUBP3

9.90e-0585810514GO:0030425
GeneOntologyCellularComponentdendritic tree

PCSK5 CALB2 GOPC MYO1D NLGN4Y MINK1 BCR RPH3A WDR47 NLGN3 TH NLGN4X CTNNB1 FUBP3

1.01e-0486010514GO:0097447
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

RIMS4 CTNNB1 UNC13A

2.03e-04231053GO:0098831
GeneOntologyCellularComponentexcitatory synapse

CALB2 NLGN4Y NLGN3 NLGN4X UNC13A

2.06e-041071055GO:0060076
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

NLGN4Y NLGN3 NLGN4X

2.31e-04241053GO:0098985
GeneOntologyCellularComponentinhibitory synapse

NLGN4Y NLGN3 NLGN4X

5.00e-04311053GO:0060077
GeneOntologyCellularComponentmigrasome

TIMM23B TIMM23

8.79e-0491052GO:0140494
GeneOntologyCellularComponentplatelet dense tubular network membrane

ATP2A1 ATP2A3

8.79e-0491052GO:0031095
GeneOntologyCellularComponentmicrovillus membrane

CUBN ITGAV CTNNB1

9.14e-04381053GO:0031528
GeneOntologyCellularComponentsomatodendritic compartment

PCSK5 CALB2 GOPC MYO1D NLGN4Y MINK1 CNKSR2 BCR RPH3A WDR47 NLGN3 TH NLGN4X CTNNB1 FUBP3

1.20e-03122810515GO:0036477
GeneOntologyCellularComponentmembrane protein complex

EPN3 STXBP5L TIMM23B TIMM23 BET1L KCNK12 ITGAV EMILIN1 TTC19 SYNE3 DNAJC15 SCN4A CTNNB1 ATP2A1 FKBP1B STX6 ATP5F1B

1.25e-03149810517GO:0098796
GeneOntologyCellularComponentplatelet dense tubular network

ATP2A1 ATP2A3

1.33e-03111052GO:0031094
GeneOntologyCellularComponentterminal bouton

CALB2 TH SLC18A1 UNC13A

1.40e-03961054GO:0043195
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

ATP2A1 FKBP1B ATP2A3

1.50e-03451053GO:0033017
GeneOntologyCellularComponentcell cortex region

RIMS4 CTNNB1 UNC13A

1.50e-03451053GO:0099738
GeneOntologyCellularComponentpresynapse

CALB2 TRIO NLGN4Y RPH3A NLGN3 TH NLGN4X SLC18A1 RIMS4 CTNNB1 UNC13A STX6

1.63e-0388610512GO:0098793
GeneOntologyCellularComponentSNARE complex

STXBP5L BET1L STX6

2.15e-03511053GO:0031201
GeneOntologyCellularComponentGolgi-associated vesicle

GOPC BET1L CUBN UNC13A

2.63e-031141054GO:0005798
GeneOntologyCellularComponentasymmetric synapse

GOPC NLGN4Y MINK1 CNKSR2 BCR NLGN3 NLGN4X CTNNB1

2.80e-034771058GO:0032279
GeneOntologyCellularComponentactin-based cell projection

CALB2 MYO1D CUBN ITGAV CTNNB1 MYO15A

2.81e-032781056GO:0098858
GeneOntologyCellularComponentinner mitochondrial membrane protein complex

TIMM23B TIMM23 DNAJC15 ATP5F1B

3.16e-031201054GO:0098800
GeneOntologyCellularComponentmicrovillus

MYO1D CUBN ITGAV CTNNB1

3.45e-031231054GO:0005902
DomainNlgn

NLGN4Y NLGN3 NLGN4X

1.62e-0651033IPR000460
DomainNLGN4

NLGN4Y NLGN4X

3.01e-0521032IPR030025
DomainIMP_DH

IMPDH1 IMPDH2

3.01e-0521032IPR005990
DomainCarboxylesterase_B_CS

NLGN4Y NLGN3 NLGN4X

4.48e-05131033IPR019819
DomainCARBOXYLESTERASE_B_2

NLGN4Y NLGN3 NLGN4X

5.67e-05141033PS00941
DomainCOesterase

NLGN4Y NLGN3 NLGN4X

5.67e-05141033PF00135
DomainCarbesteraseB

NLGN4Y NLGN3 NLGN4X

5.67e-05141033IPR002018
DomainP-type_ATPase_IIA

ATP2A1 ATP2A3

9.00e-0531032IPR005782
DomainNA-bd_OB-fold

YBX3 NABP1 EIF1AY KARS1 SUPT6H

9.55e-05831035IPR012340
DomainIMPDH

IMPDH1 IMPDH2

1.79e-0441032PF00478
DomainIMP_DH_GMPRt

IMPDH1 IMPDH2

1.79e-0441032IPR001093
DomainIMP_DH_GMP_RED

IMPDH1 IMPDH2

1.79e-0441032PS00487
DomainIMP_DH/GMP_Rdtase_CS

IMPDH1 IMPDH2

1.79e-0441032IPR015875
DomainNACHT

NLRP11 NOD1 NLRC3

2.66e-04231033PS50837
DomainNACHT_NTPase

NLRP11 NOD1 NLRC3

2.66e-04231033IPR007111
Domain-

ATP11B ATP2A1 ATP2A3

7.19e-043210333.40.1110.10
Domain-

ATP11B ATP2A1 ATP2A3

7.19e-043210332.70.150.10
DomainC2

BCR RPH3A SYT15 RIMS4 UNC13A

7.95e-041311035PF00168
DomainATPase_P-typ_cyto_domN

ATP11B ATP2A1 ATP2A3

9.38e-04351033IPR023299
DomainC2

BCR RPH3A SYT15 RIMS4 UNC13A

9.72e-041371035SM00239
DomainATPase_P-typ_P_site

ATP11B ATP2A1 ATP2A3

1.02e-03361033IPR018303
DomainP_typ_ATPase

ATP11B ATP2A1 ATP2A3

1.02e-03361033IPR001757
DomainATPASE_E1_E2

ATP11B ATP2A1 ATP2A3

1.02e-03361033PS00154
DomainATPase_P-typ_transduc_dom_A

ATP11B ATP2A1 ATP2A3

1.10e-03371033IPR008250
DomainE1-E2_ATPase

ATP11B ATP2A1 ATP2A3

1.10e-03371033PF00122
DomainPDZ

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

1.11e-031411035PF00595
DomainC2

BCR RPH3A SYT15 RIMS4 UNC13A

1.14e-031421035PS50004
DomainHydrolase_3

ATP2A1 ATP2A3

1.32e-03101032PF08282
DomainPDZ

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

1.37e-031481035SM00228
Domain-

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

1.45e-0315010352.30.42.10
DomainPDZ

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

1.50e-031511035PS50106
DomainPDZ

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

1.54e-031521035IPR001478
DomaintRNA_anti-codon

NABP1 KARS1

1.92e-03121032PF01336
DomainNA-bd_OB_tRNA

NABP1 KARS1

1.92e-03121032IPR004365
DomainC2_dom

BCR RPH3A SYT15 RIMS4 UNC13A

2.15e-031641035IPR000008
DomainPLAC

PCSK5 PAPLN

2.62e-03141032PF08686
DomainCBS

IMPDH1 IMPDH2

3.44e-03161032SM00116
DomainATPase_P-typ_TM_dom

ATP2A1 ATP2A3

3.44e-03161032IPR023298
Domain-

ATP2A1 ATP2A3

3.44e-031610321.20.1110.10
DomainLRR_6

NLRP11 NOD1 NLRC3

3.47e-03551033PF13516
DomainATPase_P-typ_cation-transptr_C

ATP2A1 ATP2A3

3.88e-03171032IPR006068
DomainCation_ATPase_C

ATP2A1 ATP2A3

3.88e-03171032PF00689
DomainCation_ATPase_N

ATP2A1 ATP2A3

4.35e-03181032PF00690
DomainCation_ATPase_N

ATP2A1 ATP2A3

4.35e-03181032SM00831
DomainPLAC

PCSK5 PAPLN

4.84e-03191032PS50900
DomainATPase_P-typ_cation-transptr_N

ATP2A1 ATP2A3

4.84e-03191032IPR004014
DomainPLAC

PCSK5 PAPLN

4.84e-03191032IPR010909
DomainCBS_dom

IMPDH1 IMPDH2

5.36e-03201032IPR000644
DomainCBS

IMPDH1 IMPDH2

5.36e-03201032PF00571
DomainCBS

IMPDH1 IMPDH2

5.36e-03201032PS51371
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN4Y NLGN3 NLGN4X

2.91e-083108332011705
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN4Y NLGN3 NLGN4X

2.91e-083108318628683
Pubmed

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.

NLGN4Y NLGN3 NLGN4X

1.16e-074108312669065
Pubmed

Homodimerization and isoform-specific heterodimerization of neuroligins.

NLGN4Y NLGN3 NLGN4X

1.16e-074108322671294
Pubmed

Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.

NLGN4Y NLGN3 NLGN4X

1.16e-074108320579107
Pubmed

Analysis of four neuroligin genes as candidates for autism.

NLGN4Y NLGN3 NLGN4X

1.16e-074108316077734
Pubmed

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

NLGN4Y NLGN3 NLGN4X

1.16e-074108317292328
Pubmed

Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.

NLGN4Y NLGN3 NLGN4X

2.90e-075108337865312
Pubmed

Synapse formation: if it looks like a duck and quacks like a duck ...

NLGN4Y NLGN3 NLGN4X

2.90e-075108310996085
Pubmed

The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?

NLGN4Y NLGN3 NLGN4X

5.78e-076108321838267
Pubmed

Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.

NLGN4Y NLGN3 NLGN4X

5.78e-076108329724786
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

STXBP5L NLGN4Y DNAH7 RPH3A SBNO2 ATP11B

8.24e-07102108610231032
Pubmed

DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.

NLGN4Y NLGN3 NLGN4X CTNNB1

1.25e-0626108434848499
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NLGN4Y NLGN3 NLGN4X

1.61e-068108330871858
Pubmed

Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.

NLGN4Y NLGN3 NLGN4X

2.41e-069108323010509
Pubmed

SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.

NLGN4Y NLGN3 NLGN4X

4.72e-0611108332973045
Pubmed

Behavioral phenotypes of genetic mouse models of autism.

NLGN4Y NLGN3 NLGN4X

4.72e-0611108326403076
Pubmed

Advancing the understanding of autism disease mechanisms through genetics.

NLGN4Y NLGN3 NLGN4X

8.14e-0613108327050589
Pubmed

Expression of IMPDH mRNA after mycophenolate administration in male volunteers.

IMPDH1 IMPDH2

9.55e-062108225105143
Pubmed

Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort.

NLGN3 NLGN4X

9.55e-062108227782075
Pubmed

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.

CALB2 TRIO

9.55e-062108211050238
Pubmed

Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.

NLGN3 NLGN4X

9.55e-062108228948087
Pubmed

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.

IMPDH1 IMPDH2

9.55e-062108220718729
Pubmed

Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.

NLGN3 NLGN4X

9.55e-062108216648374
Pubmed

A substitution involving the NLGN4 gene associated with autistic behavior in the Greek population.

NLGN3 NLGN4X

9.55e-062108219645625
Pubmed

Two distinct cDNAs for human IMP dehydrogenase.

IMPDH1 IMPDH2

9.55e-06210821969416
Pubmed

Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands.

NLGN3 NLGN4X

9.55e-062108215274046
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4Y NLGN4X

9.55e-062108223183221
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4Y NLGN4X

9.55e-062108224855039
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4Y NLGN4X

9.55e-062108237001827
Pubmed

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.

IMPDH1 IMPDH2

9.55e-062108212944494
Pubmed

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.

GOPC STX6

9.55e-062108220130090
Pubmed

No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level.

NLGN3 NLGN4X

9.55e-062108218189281
Pubmed

Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.

IMPDH1 IMPDH2

9.55e-06210822902093
Pubmed

Disorder-associated mutations lead to functional inactivation of neuroligins.

NLGN3 NLGN4X

9.55e-062108215150161
Pubmed

Characterization of human type I and type II IMP dehydrogenases.

IMPDH1 IMPDH2

9.55e-06210827903306
Pubmed

Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.

NLGN3 NLGN4X

9.55e-062108215622415
Pubmed

Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.

IMPDH1 IMPDH2

9.55e-06210827763314
Pubmed

Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.

GOPC STX6

9.55e-062108211384996
Pubmed

Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

IMPDH1 IMPDH2

9.55e-062108214766016
Pubmed

PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche.

PTPN13 CTNNB1

9.55e-062108226344907
Pubmed

Unusually rapid evolution of Neuroligin-4 in mice.

NLGN4Y NLGN4X

9.55e-062108218434543
Pubmed

Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.

IMPDH1 IMPDH2

9.55e-06210827896827
Pubmed

Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.

IMPDH1 IMPDH2

9.55e-062108220679962
Pubmed

Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland.

TIMM23B TIMM23

9.55e-062108211165051
Pubmed

Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism.

NLGN3 NLGN4X

9.55e-062108223431752
Pubmed

Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation.

IMPDH1 IMPDH2

9.55e-062108217713475
Pubmed

Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.

NLGN4Y NLGN4X

9.55e-062108237080762
Pubmed

Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection.

NLGN3 NLGN4X

9.55e-062108216508939
Pubmed

Mutants of purine metabolism in cultured mouse and hamster cells.

IMPDH1 IMPDH2

9.55e-0621082988789
Pubmed

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

NLGN4Y NLGN4X

9.55e-062108229106499
Pubmed

NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population.

NLGN3 NLGN4X

9.55e-062108215389766
Pubmed

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

NLGN4Y NLGN4X

9.55e-062108226456829
Pubmed

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.

NLGN4Y NLGN4X

9.55e-062108224104404
Pubmed

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

NLGN4Y NLGN4X

9.55e-062108232243781
Pubmed

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

NLGN4Y NLGN4X

9.55e-062108222989184
Pubmed

Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor.

THRB CTNNB1

9.55e-062108218474620
Pubmed

Effect of Tim23 knockdown in vivo on mitochondrial protein import and retrograde signaling to the UPRmt in muscle.

TIMM23B TIMM23

9.55e-062108229949403
Pubmed

Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.

NLGN3 NLGN4X

9.55e-062108224570023
Pubmed

Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism.

NLGN3 NLGN4X

9.55e-062108223851596
Pubmed

Genetic and structural characterization of the human mitochondrial inner membrane translocase.

TIMM23B TIMM23 DNAJC15

1.03e-0514108310339406
Pubmed

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.

NLGN4Y NLGN3 NLGN4X

1.29e-0515108318227507
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SPTLC3 TRIO STXBP5L NLGN4Y TTC21A CAPN1 MINK1 BCR TTC19 SBNO2 NLGN3 PTPN13 THRB ATP11B SUPT6H POLK

1.45e-0514891081628611215
Pubmed

Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.

CALB2 LHX9 TH

1.58e-0516108324333658
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

EPN3 ARMC3 MYO1D CAPN1 MINK1 CNKSR2 CUBN NEB ITGAV BCR PTPN13 MYO15A ATP5F1B

1.66e-0510161081319056867
Pubmed

CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains.

CALB2 TH CTNNB1

2.30e-0518108333462112
Pubmed

Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2.

CELF6 CALB2 TH

2.30e-0518108324066094
Pubmed

The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.

CAPN1 PTPN13

2.86e-053108228924170
Pubmed

Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.

MINK1 CTNNB1

2.86e-053108215469942
Pubmed

Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes.

TIMM23B TIMM23

2.86e-053108212437925
Pubmed

Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease.

NLGN3 NLGN4X

2.86e-053108229622757
Pubmed

Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells.

THRB CTNNB1

2.86e-053108221994129
Pubmed

T cell activation triggers reversible inosine-5'-monophosphate dehydrogenase assembly.

IMPDH1 IMPDH2

2.86e-053108230154209
Pubmed

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson's disease.

TIMM23B TIMM23

2.86e-053108230405116
Pubmed

Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.

ARFGEF1 CTNNB1

2.86e-053108227162341
Pubmed

NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.

TIMM23B TIMM23

2.86e-053108237044213
Pubmed

c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.

IMPDH1 IMPDH2

2.86e-053108236629054
Pubmed

Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.

IMPDH1 IMPDH2

2.86e-053108220061166
Pubmed

Mutant huntingtin does not cross the mitochondrial outer membrane.

TIMM23B TIMM23

2.86e-053108232821928
Pubmed

Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice.

TIMM23B TIMM23

2.86e-053108231326434
Pubmed

The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors.

ATP2A1 ATP2A3

2.86e-053108216410239
Pubmed

Association of Y chromosome haplotypes with autism.

NLGN4Y EIF1AY

2.86e-053108219605777
Pubmed

ATP11B mediates platinum resistance in ovarian cancer.

ATP11B STX6

2.86e-053108223585472
Pubmed

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

NLGN4Y NLGN4X

2.86e-053108221282647
Pubmed

Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy.

THRB ATP2A1

2.86e-053108217317766
Pubmed

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.

PTPN13 CTNNB1

2.86e-053108210951583
Pubmed

Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.

CALB2 TH SLC18A1

3.19e-0520108323637192
Pubmed

Prss56, a novel marker of adult neurogenesis in the mouse brain.

CALB2 TH CTNNB1

3.72e-0521108326701169
Pubmed

Diabetogenic response to streptozotocin varies among obese yellow and among lean agouti (BALB/c x VY)F1 hybrid mice.

CALB2 TH CTNNB1

3.72e-052110832137249
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPN3 PCSK5 CRYBG2 IMPDH1 TRIO TIMM23B NSD1 PAPLN BCR SBNO2 SYNE3 TMCC2 ATP2A3

3.96e-0511051081335748872
Pubmed

Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification.

CALB2 TH SLC18A1

4.93e-0523108331850343
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

GOPC TRIO STXBP5L MINK1 CNKSR2 BCR RPH3A WDR47 YTHDF1 TMCC2 CTNNB1 UNC13A ATP5F1B

5.39e-0511391081336417873
Pubmed

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.

TIMM23B TIMM23

5.71e-054108219111522
Pubmed

Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.

HTRA1 CAPN1

5.71e-054108222535953
Pubmed

Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.

MSH2 CTNNB1

5.71e-054108215888344
Pubmed

Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.

TH CTNNB1

5.71e-054108226772978
Pubmed

The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix.

TIMM23B TIMM23

5.71e-054108210393182
Pubmed

Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity.

ITGAV CTNNB1

5.71e-054108227248172
Pubmed

Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.

ATP2A1 ATP2A3

5.71e-054108225110346
Pubmed

Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.

NLGN3 NLGN4X

5.71e-054108223468870
Cytoband10p12.31

ARMC3 CUBN NSUN6

1.89e-0522108310p12.31
Cytoband2q32.3

NABP1 DNAH7

3.56e-041210822q32.3
GeneFamilyNLR family

NLRP11 NOD1 NLRC3

1.66e-0425783666
GeneFamilyPDZ domain containing

HTRA1 GOPC CNKSR2 GIPC3 PTPN13

5.07e-041527851220
GeneFamilyATPases Ca2+ transporting

ATP2A1 ATP2A3

6.49e-0497821209
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC21A TTC19 TTC31 GPSM1

1.54e-03115784769
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIO ITGAV EMILIN1 TH GPSM1 FKBP1B ATP2A3 SEC14L1

2.62e-081951088bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

CRYBG2 CAPN1 PTPN13 ATP11B NECTIN4 PRRG4 STX6

2.39e-0717510870cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CAPN1 PAPLN PTPN13 TTC31 MDC1 ATP2A3

3.58e-061691086c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4Y PCDHB10 SLC24A3 EMILIN1 NLGN4X COL14A1

4.24e-0617410869c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLGN4Y PCDHB10 SLC24A3 EMILIN1 NLGN4X COL14A1

4.24e-061741086bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

HTRA1 SCARF2 EMILIN1 ZNF469 COL14A1 CNN1

5.84e-0618410860b336489c10e8c3c957795dd845454f03404382b
ToppCellfacs-Skin-nan-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 CRYBG2 CAPN1 SLC24A3 WDR47 NECTIN4

5.84e-061841086dc7f6ee4062856a02423fff8b1cce62d46a9355c
ToppCellfacs-Marrow-KLS-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 IMPDH2 YBX3 KCNK12 MSH2 EMILIN1

6.81e-061891086533685a921a65d84107d8d33c43b4fffde019143
ToppCellfacs-Marrow-KLS-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 IMPDH2 YBX3 KCNK12 MSH2 EMILIN1

6.81e-061891086dca56ab02bf0505f9a352ff907edaef30906d854
ToppCellfacs-Marrow-KLS-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 IMPDH2 YBX3 KCNK12 MSH2 EMILIN1

7.01e-061901086a513c1e7df62c28128c932a68b252ee8f0255172
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

STXBP5L FAM3B SLC18A1 KIF19 ATP2A3 UNC13A

7.67e-0619310868603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCellTracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CNKSR2 KCNK12 CUBN ITIH3 NLGN3 KIF19

9.13e-0619910862b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDHB9 NLGN3 NLGN4X TMCC2 KIF19

4.43e-05160108514dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDHB9 NLGN3 NLGN4X TMCC2 KIF19

4.43e-051601085839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDHB9 NLGN3 NLGN4X TMCC2 KIF19

4.43e-0516010855b7789d4668ed7732babedc32d812233b430e0bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDHB9 NLGN3 NLGN4X TMCC2 KIF19

4.43e-051601085bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L KCNK12 RPH3A FKBP1B UNC13A

5.28e-051661085ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCellfacs-Skin-Anagen-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 CRYBG2 SLC24A3 PTPN13 NECTIN4

5.43e-05167108502c89069dcd0e87f7502e32b14e7cbd3cab81a09
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

STXBP5L NEB RPH3A TMCC2 UNC13A

6.08e-051711085b2e753e811a7639956994609f73efcdb62d04f82
ToppCellmild-Myeloid-Eosinophils|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SLC24A3 CNKSR2 KCNK12 ACSF2 ATP2A3

6.08e-0517110855c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCellfacs-Skin-nan-24m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 CRYBG2 SLC24A3 FAM3B NECTIN4

6.25e-0517210855ca89af7406e7e1a055dd60d6f89615f69e62324
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enteroendocrine_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L CNKSR2 KCNK12 SLC18A1 TMCC2

7.35e-05178108530ca37f70d267cc9b40ca3e211f16d30360c3e6b
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HTRA1 SCARF2 PAPLN EMILIN1 ZNF469

7.74e-051801085935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HTRA1 SCARF2 PAPLN EMILIN1 ZNF469

7.74e-0518010853dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

STXBP5L KCNK12 BCR SYNE3 ATP2A3

7.95e-05181108551e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HTRA1 SYT15 ATP2A3 SEC14L1

8.37e-05183108512e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HTRA1 SCARF2 PAPLN EMILIN1 ZNF469

8.37e-051831085803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HTRA1 SCARF2 PAPLN EMILIN1 ZNF469

8.37e-0518310856d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HTRA1 SCARF2 PAPLN EMILIN1 ZNF469

8.37e-051831085cc7f5a17b40e8d901885174922e5fa8877643071
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 HTRA1 SLC24A3 OVCH1 SYNE3

8.59e-0518410857f6c8912677764d438ab0555faca344d74c2f483
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALB2 STXBP5L CNKSR2 KCNK12 RPH3A

8.81e-051851085c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CALB2 TRIO SLC24A3 ITGAV ATP2A3

9.04e-051861085de55471dd5c842026b409cfebf67fe32f079a011
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

STXBP5L FAM3B SLC18A1 KIF19 ATP2A3

9.04e-051861085dfd67d67c103c942de6c8acef8d81e57a9886154
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CNKSR2 NLGN3 PTPN13 PRRG4 DHRS2

9.27e-0518710856f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|metastatic_Lymph_Node / Location, Cell class and cell subclass

PAPLN EMILIN1 ITIH3 NLGN4X KIF25-AS1

9.27e-051871085e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STXBP5L SLC18A1 KIF19 DHRS2 ATP2A3

9.50e-051881085b6aad90fa77fbaf80487a55415aa6c245f2d1f7e
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

PCSK5 HTRA1 SCARF2 PAPLN COL14A1

9.50e-051881085c90669b51e1902fe7726555290c91c92a911df83
ToppCelldroplet-Marrow-nan-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 KCNK12 EMILIN1 TMEM147 ATP2A1

9.99e-051901085240923769fef18eaf73d2efa3d5f745f5533b0ce
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

STXBP5L FAM3B SLC18A1 KIF19 UNC13A

9.99e-0519010852375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

STXBP5L SLC18A1 KIF19 ATP2A3 UNC13A

9.99e-051901085b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 KCNK12 EMILIN1 TMEM147 ATP2A1

9.99e-0519010859df9b9e91c97e504c189d6055a6aabc54ad17cec
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

STXBP5L FAM3B SLC18A1 KIF19 UNC13A

1.02e-04191108519832ddd559a353e1618fe853d79e3edfec6dcda
ToppCell11.5-Airway-Epithelial-Neuroendocrine|Airway / Age, Tissue, Lineage and Cell class

STXBP5L FAM3B SLC18A1 KIF19 ATP2A3

1.02e-041911085c1bb3ae5c297f55cdadf5b6e53d5296389d5099e
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 IMPDH2 KCNK12 MSH2 EMILIN1

1.05e-04192108503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STXBP5L SLC18A1 KIF19 DHRS2 UNC13A

1.05e-0419210855692bd57093852d442400383850f416c497dcc7d
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

STXBP5L FAM3B SLC18A1 KIF19 UNC13A

1.05e-0419210854d3a1c267739b1479217144656986972fc86db43
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IMPDH1 YBX3 KCNK12 MSH2 EMILIN1

1.10e-041941085c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCellLAM-LAM-LAM+|LAM / Condition, Lineage and Cell class

HTRA1 STXBP5L EMILIN1 COL14A1 CNN1

1.10e-0419410854ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HTRA1 ARMC3 TRIO NLGN3 NSUN6

1.10e-04194108568d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ARMC3 DNAH7 THRB NECTIN4 PRRG4

1.10e-0419410856b286992d4bb56013c0ea5a7601d3476d806175a
ToppCellLAM-LAM|LAM / Condition, Lineage and Cell class

HTRA1 STXBP5L EMILIN1 COL14A1 CNN1

1.10e-0419410854c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMILIN1 TH GPSM1 FKBP1B ATP2A3

1.13e-04195108558b769da05a8f6b05aeb08d4f8b112941087ad00
ToppCellCOPD-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

SLC24A3 NABP1 PPM1L NECTIN4 CTNNB1

1.16e-041961085af96fb94886e9395f3e2cd0a293af29229d017fe
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 CAPN1 FAM3B NECTIN4 ATP5F1B

1.21e-0419810859718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 CAPN1 FAM3B NECTIN4 ATP5F1B

1.21e-04198108589ec1e760a193441092571475cc66a3b425f232e
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HTRA1 EMILIN1 ITIH3 ZNF469 COL14A1

1.21e-0419810859541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

CRYBG2 ARMC3 TTC21A DNAH7 KIF19

1.21e-041981085e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

CRYBG2 ARMC3 TTC21A DNAH7 KIF19

1.21e-041981085e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HTRA1 SCARF2 EMILIN1 COL14A1

1.21e-041981085524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EPN3 CAPN1 FAM3B PTPN13 NECTIN4

1.21e-04198108558f5b5e756ab4aa7234aa8d95fba564d6e8c22d9
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 EMILIN1 PTPN13 NLGN4X COL14A1

1.21e-041981085bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCARF2 PAPLN CNKSR2 WDR47 UNC13A

1.24e-041991085fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCellsuprabasal_cell|World / shred by cell class for turbinate

IMPDH2 CAPN1 FAM3B YBX3 ATP5F1B

1.24e-041991085bfab5380ef074d14f0b5ed10851ad5c898eb9a58
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Intermediate|GW10 / Sample Type, Dataset, Time_group, and Cell type.

IMPDH1 DNAH7 SBNO2 SLC18A1 RIMS4

1.24e-041991085cf592d93612023a13de21e0fb8c6b13714f9af71
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MYO1D YBX3 PTPN13 NECTIN4 PRRG4

1.27e-04200108597f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EPN3 IMPDH2 CAPN1 FAM3B ATP5F1B

1.27e-042001085694ebc8cc14f80b6f2f4acec4ce7452d8b816af8
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm|1m / Sample Type, Dataset, Time_group, and Cell type.

RPH3A SYT15 KIF19 DHRS2 CNN1

1.27e-042001085c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC22A25 MYO1D STXBP5L CNKSR2 PPM1L

1.27e-0420010854409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MYO1D YBX3 PTPN13 NECTIN4 PRRG4

1.27e-042001085ecbe89ff95d046155b984c8c150e0b9e7278f839
DrugDoxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

MYO1D TRIO MINK1 SLC24A3 TUT1 BCR TH SUPT6H

4.11e-0619610784819_DN
DrugPNU-0230031 [267429-39-0]; Up 200; 1uM; MCF7; HT_HG-U133A

CALB2 TRIO MINK1 BET1L NABP1 UBA7 THRB SCN4A

4.27e-0619710783632_UP
Drughydroxymethylphosphonate

IMPDH1 IMPDH2

2.19e-0521072CID000075795
Drug6-Chloropurine Riboside, 5'-Monophosphate

IMPDH1 IMPDH2

2.19e-0521072DB03948
DrugMycophenolate mofetil

IMPDH1 IMPDH2

2.19e-0521072DB00688
Drugpurinogen

IMPDH1 IMPDH2

2.19e-0521072CID003081226
DrugAC1L9X6T

IMPDH1 IMPDH2

2.19e-0521072CID000477594
DrugMycophenolic acid

IMPDH1 IMPDH2

2.19e-0521072DB01024
Drugtrimethyl phosphate

IMPDH2 NSD1 ATP2A1 ATP2A3

3.34e-05391074CID000010541
DrugCorynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A

SPTLC3 TRIO MINK1 TUT1 SBNO2 CASKIN2 MYO15A

3.97e-0519610774227_DN
DrugAnabasine [494-52-0]; Up 200; 24.6uM; MCF7; HT_HG-U133A

TRIO MINK1 CNKSR2 BCR UBA7 THRB ATP2A1

3.97e-0519610776774_UP
DrugFK-506; Up 200; 1uM; MCF7; HG-U133A

TRIO ARFGEF1 SBNO2 NOD1 SUPT6H PRRG4 ATP2A3

4.10e-051971077284_UP
DrugFolinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; PC3; HT_HG-U133A

CRYBG2 NEB PASK THRB COL14A1 ATP2A3 STX6

4.10e-0519710777401_UP
DrugSotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A

TRIO STXBP5L SLC24A3 CNKSR2 KCNK12 DNAH7 THRB

4.10e-0519710774160_UP
DrugCyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

PCSK5 CRYBG2 DNAH7 RPH3A SCN4A COL14A1 MYO15A

4.23e-0519810774358_UP
DrugCanrenoic acid potassium salt [2181-04-6]; Up 200; 10uM; MCF7; HT_HG-U133A

CRYBG2 BET1L KCNK12 DNAH7 RPH3A THRB PRRG4

4.23e-0519810772228_UP
DrugPiperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; HL60; HT_HG-U133A

SPTLC3 CRYBG2 BET1L CNKSR2 TUT1 DNAH7 NLGN4X

4.23e-0519810776129_UP
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A

SPTLC3 MINK1 SLC24A3 KCNK12 SBNO2 EIF1AY COL14A1

4.37e-0519910774691_DN
DrugZidovudine, AZT [30516-87-1]; Up 200; 15uM; MCF7; HT_HG-U133A

TUT1 NEB SBNO2 EIF1AY TH SUPT6H ATP2A3

4.37e-0519910775333_UP
DrugAC1L59F0

IMPDH1 IMPDH2

6.54e-0531072CID000220847
DrugAC1L9X6Q

IMPDH1 IMPDH2

6.54e-0531072CID000477593
Drugoxanosine-5'-monophosphate

IMPDH1 IMPDH2

6.54e-0531072CID000477551
DiseaseBrody myopathy (implicated_via_orthology)

ATP2A1 ATP2A3

3.83e-0531062DOID:0050692 (implicated_via_orthology)
Diseasemuscular atrophy (biomarker_via_orthology)

HSP90AB4P TIMM23B TIMM23

1.54e-04291063DOID:767 (biomarker_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

NLGN4Y NLGN3 NLGN4X RIMS4 CTNNB1

2.26e-041521065DOID:0060041 (implicated_via_orthology)
Diseasecolon cancer (is_implicated_in)

HTRA1 MSH2 PTPN13

2.95e-04361063DOID:219 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

TRIO MINK1 SLC24A3 SCN4A UNC13A

3.13e-041631065DOID:1826 (implicated_via_orthology)
Diseasesciatic neuropathy (biomarker_via_orthology)

PCSK5 CAPN1 NLGN3 KARS1

4.56e-04991064DOID:11446 (biomarker_via_orthology)
DiseasePeritoneal Neoplasms

CALB2 CTNNB1

5.65e-04101062C0031149
DiseaseCarcinomatosis of peritoneal cavity

CALB2 CTNNB1

5.65e-04101062C0346990
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

HTRA1 MSH2 COL14A1

5.73e-04451063DOID:3748 (is_implicated_in)
Diseaselung adenocarcinoma (is_implicated_in)

HTRA1 MSH2 PTPN13

7.36e-04491063DOID:3910 (is_implicated_in)
DiseaseCongenital myopathy (disorder)

NEB SCN4A

8.24e-04121062C0270960
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

GIPC3 KARS1 MYO15A

8.28e-04511063cv:CN043650
Diseaseglucose metabolism measurement, age-related hearing impairment

PCSK5 MYO1D ZNF469

8.76e-04521063EFO_0005782, EFO_0009367
Diseasecolorectal cancer (is_implicated_in)

MSH2 YTHDF1 PTPN13 CTNNB1

9.68e-041211064DOID:9256 (is_implicated_in)
Diseasecardiomyopathy (biomarker_via_orthology)

FKBP1B ATP5F1B

9.72e-04131062DOID:0050700 (biomarker_via_orthology)
Diseaseamyotrophic lateral sclerosis, age at onset

PCSK5 SLC18A1

1.30e-03151062EFO_0004847, MONDO_0004976
DiseaseMalignant neoplasm of endometrium

MSH2 CTNNB1

1.88e-03181062C0007103
DiseaseCarcinoma in situ of endometrium

MSH2 CTNNB1

1.88e-03181062C0346191
DiseaseHereditary hearing loss and deafness

GIPC3 KARS1 SCN4A MYO15A

1.93e-031461064cv:C0236038
Diseasemelanoma

GOPC CAPN1 CUBN DNAJC15 CTNNB1

2.05e-032481065C0025202
Diseaseselenium measurement, response to dietary selenium supplementation

TRIO SLC18A1

2.33e-03201062EFO_0006331, EFO_0600021
DiseaseAutistic Disorder

MYO1D NSD1 PASK NLGN3 NLGN4X

2.56e-032611065C0004352
Diseaseepilepsy (biomarker_via_orthology)

CAPN1 TH

2.57e-03211062DOID:1826 (biomarker_via_orthology)
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

TH ATP5F1B

2.57e-03211062DOID:11612 (biomarker_via_orthology)
DiseaseNonsyndromic genetic hearing loss

GIPC3 KARS1 MYO15A

2.62e-03761063cv:C5680182
Diseasehemoglobin measurement, mean corpuscular hemoglobin

TIMM23 THRB

2.82e-03221062EFO_0004509, EFO_0004527
DiseaseNonsyndromic Deafness

GIPC3 KARS1 MYO15A

3.14e-03811063C3711374

Protein segments in the cluster

PeptideGeneStartEntry
NKVRMQLQEARGEGE

UNC13A

456

Q9UPW8
KGEIQARNLGMAVEA

AACS

456

Q86V21
GESTDRLMGKGQVQL

BCR

991

P11274
LSKIAQGRGSQELGM

ARFGEF1

586

Q9Y6D6
KERMALEGIGIGSGQ

EPN3

151

Q9H201
GQDNRKLLCGMAVGL

BET1L

81

Q9NYM9
QVLRVKGADGMILGG

SPATA5

191

Q8NB90
VDMQKLLGGQIGLED

GIPC3

86

Q8TF64
VGRSKDMIIRGGENI

ACSF2

506

Q96CM8
EVMLQNDSRKGVIGG

ARMC3

826

Q5W041
LMDRDGNGKLGLVEF

CAPN1

596

P07384
GEDRKLFVGMLGKQQ

CELF6

131

Q96J87
LFVGMLGKQQGEEDV

CELF6

136

Q96J87
DAGIRVIMITGDNKG

ATP2A1

616

O14983
QAGIRVVMITGDNKG

ATP2A3

616

Q93084
IAMDGTEGLVRGQKV

ATP5F1B

111

P06576
RTGMDRGVGLTADQK

CCDC113

86

Q9H0I3
MQGERGGGAALKENV

NSD1

1531

Q96L73
GRVQQIQLLGRDMKG

GOPC

216

Q9HD26
QEGAKMAVRLAGGLQ

CTNNB1

266

P35222
GLCQKAQLERMGVSG

PASK

566

Q96RG2
GIQGRGRQTVDKVMG

MDC1

801

Q14676
MRKQEVRTGREAGQG

NLRC3

1

Q7RTR2
RMVKGGQEAGGQLRV

MYO15A

2801

Q9UKN7
KIEDAGMQLLCGGLR

NLRP11

871

P59045
QAKRMDEQRVDLAGG

GPSM1

641

Q86YR5
GIGMTKADLINNLGA

HSP90AB4P

66

Q58FF6
KNLIDAGVDALRVGM

IMPDH2

311

P12268
NAKIGGVRMLDGDVT

PCSK5

236

Q92824
GGVGALGIMNNRLAE

KCNK12

411

Q9HB15
RLAKGAQLNGRDAGM

LHX9

46

Q9NQ69
DKMVGFIIGRGGEQI

FUBP3

86

Q96I24
LNGGRMKLTQTDELG

HEATR6

246

Q6AI08
AQVIKMLGNGRLEAL

EIF1AY

36

O14602
LGDAGVGKSMLLQRL

NOD1

201

Q9Y239
KINIQAMDGGGLSAR

PCDHB10

316

Q9UN67
MGDIFKNNGVLQGRL

KIF25-AS1

1

Q9Y6Z4
EGMRGAGLSCEQLKQ

NSUN6

406

Q8TEA1
LLMGEQLGNVARGIN

FAM3B

96

P58499
MGREQDLILAVKNGD

CASKIN2

1

Q8WXE0
ERRTKGAGNMVNGLA

SLC24A3

266

Q9HC58
KNLIDAGVDGLRVGM

IMPDH1

311

P20839
SGQGEKAGMGQLREQ

KIF19

411

Q2TAC6
IMLGVNQGEGLKFVE

NLGN3

401

Q9NZ94
DIMLGVNQGEGLKFV

NLGN4Y

366

Q8NFZ3
LTDGVGRREKGFQMQ

CUBN

1371

O60494
LKGVVNAALGQEMGS

TTC26

321

A0AVF1
QRGGKELGLRNSDMD

HTRA1

301

Q92743
GFGNLLAKQLVDRGM

SDR9C7

36

Q8NEX9
GGFEQKMSRREAGLI

DNAJC15

86

Q9Y5T4
EEGAAQMSLGQRAKL

FKBP1B

61

P68106
KGERGERGDLQSQAM

COL14A1

1601

Q05707
MDRGSDGKLQEVGQV

ITGAV

331

P06756
SQMFEGQILDVKGGR

CRYBG2

1621

Q8N1P7
QRGINAGADILMFEG

DNAH7

1401

Q8WXX0
NGDGKLGLSEMSRLL

CALB2

166

P22676
MQAALLEKLVGGQAG

EMILIN1

771

Q9Y6C2
EQLEGRNKMLQGPGR

FAM240C

61

A0A1B0GVR7
QNVDRAMAKLQGEGL

DHRS2

71

Q13268
MAFQDLLDQVGGLGR

SLC22A25

1

Q6T423
LGQMDTKGLVRALGE

SEC14L1

346

Q92503
TAGDMGKLRQIIQRG

MSH2

206

P43246
DIMLGVNQGEGLKFV

NLGN4X

366

Q8N0W4
FQIIGGEKMGRLDLG

PTPN13

1106

Q12923
KINIQAMDGGGLSAR

PCDHB9

316

Q9Y5E1
TENGLMLLDRSGQGK

MINK1

1036

Q8N4C8
MEGDKSQQLGRVVVG

SYT15

371

Q9BQS2
DRLENMRKNVAGDGV

RPH3A

81

Q9Y2J0
GRGGELQKIGEFCMV

NABP1

91

Q96AH0
DGEMNNLQIAIGRIK

SCN4A

816

P35499
VLRDMQQGLKDVGAN

TMCC2

376

O75069
MGDVEIGLQERNGQL

RIMS4

116

Q9H426
LQGLQEEGLDLGAQM

SYNE3

591

Q6ZMZ3
DLRGEGVKLQVMANS

KARS1

146

Q15046
DKGMTNINDGLLRGI

ITIH3

356

Q06033
QEVNGSQRGKGILDM

OVCH1

321

Q7RTY7
GKVAEIMQNDRLGGL

PPM1L

61

Q5SGD2
GVLKNMSQRIGGELE

STX6

181

O43752
RDMKQGLLSVGIGGR

SBNO2

936

Q9Y2G9
KLIMGLDGTTQGLQR

SPTLC3

416

Q9NUV7
RGQRLGELEEKTAGM

STXBP5L

1146

Q9Y2K9
LAESERMQVLNGNGG

CNKSR2

826

Q8WXI2
VTGRRIGNNFMDGLK

CNN1

41

P51911
IGNNFMDGLKDGIIL

CNN1

46

P51911
IGIMGKEGRQAARNS

ATP11B

836

Q9Y2G3
MDENQGKGIRVLGIA

SUPT6H

771

Q7KZ85
QMEKQGDGFRALAGL

URGCP

851

Q8TCY9
LLGGGMKQEDNAIIE

TTC19

166

Q6DKK2
QKLGELNIGMDGLGN

WDR47

481

O94967
PNRIQAGEIGEMKDG

YBX3

256

P16989
QGLGAEVAKNLVLMG

UBA7

41

P41226
DSQKIQLRIIGGDMA

PAPLN

986

O95428
AADVGAQMIKLVGLR

TUT1

156

Q9H6E5
ETNQRKGVMGAGALL

SCARF2

436

Q96GP6
NGEMAVTRGQLKNGG

THRB

331

P10828
LLRMGLNDNKAGMEG

POLK

16

Q9UBT6
DGNREKIDVMGLLTG

PRRG4

106

Q9BZD6
GAMNGLRLGLKETQN

TIMM23B

91

Q5SRD1
EQGIQDTKDVLGLMG

TTC21A

171

Q8NDW8
KGAREAGGQAQAMEL

ZNF469

46

Q96JG9
ATQREGNLGGKIQME

ZNF225

71

Q9UK10
REGNSGGKIQIEMET

ZNF221

96

Q9UK13
LIGLNLVMSRNAGKG

TMEM147

81

Q9BVK8
GAMNGLRLGLKETQN

TIMM23

91

O14925
MNVGRLQGFDGKIVA

TRIO

2146

O75962
NSLEQGMVGLKIGDV

YTHDF1

181

Q9BYJ9
EPQGRGLALQKMGQE

TTC31

261

Q49AM3
IGTNLFGVLANKMGR

SLC18A1

351

P54219
LDAKQAEAIMVRGQG

TH

21

P07101
ASGINMIKLIREDGG

ZNF554

171

Q86TJ5
AVEMLKGQRADLGLQ

MYO1D

806

O94832
ELEVKGRGLNAMANE

NEB

6016

P20929
IGREGAMLKCLSEGQ

NECTIN4

261

Q96NY8