Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRAF2 MARCHF4

5.34e-0347352GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRAF2 MARCHF4

6.23e-0351252GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRAF2 MARCHF4

6.72e-0353252GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

TRAF2 MARCHF4

1.39e-0277552GO:0016746
GeneOntologyMolecularFunctionzinc ion binding

TRAF2 MARCHF4

1.82e-0289152GO:0008270
GeneOntologyBiologicalProcessregulation of T cell mediated immunity

TRAF2 CD274

1.71e-0411142GO:0002709
GeneOntologyBiologicalProcessprotein ubiquitination

TRAF2 MARCHF4 KBTBD8

2.35e-0481143GO:0016567
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

TRAF2 CD274

3.12e-0415042GO:0002824
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

TRAF2 MARCHF4 KBTBD8

3.13e-0489343GO:0032446
GeneOntologyBiologicalProcesspositive regulation of adaptive immune response

TRAF2 CD274

3.51e-0415942GO:0002821
GeneOntologyBiologicalProcessT cell mediated immunity

TRAF2 CD274

3.69e-0416342GO:0002456
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

TRAF2 MARCHF4 KBTBD8

4.50e-04100943GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

TRAF2 MARCHF4 KBTBD8

5.41e-04107443GO:0043687
GeneOntologyBiologicalProcessregulation of lymphocyte mediated immunity

TRAF2 CD274

7.45e-0423242GO:0002706
GeneOntologyBiologicalProcessregulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

TRAF2 CD274

7.64e-0423542GO:0002822
GeneOntologyBiologicalProcessregulation of adaptive immune response

TRAF2 CD274

8.78e-0425242GO:0002819
GeneOntologyBiologicalProcessregulation of leukocyte mediated immunity

TRAF2 CD274

1.32e-0330942GO:0002703
GeneOntologyBiologicalProcesslymphocyte mediated immunity

TRAF2 CD274

2.76e-0344942GO:0002449
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

TRAF2 CD274

2.92e-0346242GO:0002460
GeneOntologyBiologicalProcessregulation of immune effector process

TRAF2 CD274

3.37e-0349742GO:0002697
GeneOntologyBiologicalProcessleukocyte mediated immunity

TRAF2 CD274

4.50e-0357642GO:0002443
GeneOntologyBiologicalProcesspositive regulation of cytokine production

TRAF2 CD274

4.65e-0358642GO:0001819
GeneOntologyBiologicalProcesspositive regulation of apoptotic process

TRAF2 CD274

6.93e-0371842GO:0043065
GeneOntologyBiologicalProcesspositive regulation of programmed cell death

TRAF2 CD274

7.33e-0373942GO:0043068
GeneOntologyBiologicalProcessadaptive immune response

TRAF2 CD274

9.37e-0383842GO:0002250
GeneOntologyBiologicalProcesspositive regulation of immune response

TRAF2 CD274

9.52e-0384542GO:0050778
GeneOntologyBiologicalProcessimmune effector process

TRAF2 CD274

9.83e-0385942GO:0002252
GeneOntologyBiologicalProcessregulation of cytokine production

TRAF2 CD274

1.35e-02101042GO:0001817
GeneOntologyCellularComponentubiquitin ligase complex

TRAF2 KBTBD8

2.73e-0335252GO:0000151
GeneOntologyCellularComponentactin cytoskeleton

IPP CD274

7.17e-0357652GO:0015629
DomainBTB-kelch_protein

IPP KBTBD8

5.15e-054352IPR017096
Domain-

IPP KBTBD8

6.44e-0548522.120.10.80
DomainKelch-typ_b-propeller

IPP KBTBD8

8.47e-055552IPR015915
DomainKelch

IPP KBTBD8

9.42e-055852SM00612
DomainGal_Oxase/kelch_b-propeller

IPP KBTBD8

9.75e-055952IPR011043
DomainBACK

IPP KBTBD8

1.01e-046052SM00875
DomainBACK

IPP KBTBD8

1.04e-046152PF07707
DomainBACK

IPP KBTBD8

1.04e-046152IPR011705
DomainKelch_1

IPP KBTBD8

1.37e-047052PF01344
DomainKelch_1

IPP KBTBD8

1.37e-047052IPR006652
DomainBTB

IPP KBTBD8

4.82e-0413152PF00651
DomainBTB

IPP KBTBD8

7.17e-0416052PS50097
DomainZnf_C3HC4_RING-type

TRAF2 MARCHF4

8.28e-0417252IPR018957
DomainBTB

IPP KBTBD8

9.06e-0418052SM00225
DomainBTB/POZ_dom

IPP KBTBD8

9.57e-0418552IPR000210
DomainSKP1/BTB/POZ

IPP KBTBD8

9.98e-0418952IPR011333
Domainzf-C3HC4

TRAF2 MARCHF4

1.39e-0322352PF00097
DomainZnf_RING

TRAF2 MARCHF4

2.93e-0332652IPR001841
Domain-

TRAF2 MARCHF4

5.50e-03449523.30.40.10
DomainZnf_RING/FYVE/PHD

TRAF2 MARCHF4

5.74e-0345952IPR013083
PathwayWP_PLEURAL_MESOTHELIOMA

TRAF2 CD274

2.84e-0343932M42563
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

CD274 KBTBD8

7.53e-0371932MM14540
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

CD274 KBTBD8

9.93e-0382832M1058
InteractionCAPN15 interactions

TRAF2 MARCHF4

2.44e-053252int:CAPN15
GeneFamilyBasic leucine zipper proteins|BTB domain containing

IPP KBTBD8

5.37e-0413452861
GeneFamilyRing finger proteins

TRAF2 MARCHF4

2.24e-032755258
CoexpressionDUTTA_APOPTOSIS_VIA_NFKB

TRAF2 CD274

1.53e-053352M9440
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_ADC_2_CELL

TRAF2 CD274

1.52e-0410352M45742
CoexpressionGSE3920_UNTREATED_VS_IFNG_TREATED_ENDOTHELIAL_CELL_UP

TRAF2 CD274

3.39e-0415452M6695
CoexpressionGSE6092_B_BURGDOFERI_VS_B_BURGDORFERI_AND_IFNG_STIM_ENDOTHELIAL_CELL_DN

TRAF2 CD274

4.63e-0418052M6717
CoexpressionGSE10856_CTRL_VS_TNFRSF6B_IN_MACROPHAGE_DN

IPP KBTBD8

5.43e-0419552M3101
CoexpressionGSE42724_MEMORY_VS_B1_BCELL_DN

TRAF2 CD274

5.54e-0419752M9801
CoexpressionGSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN

TRAF2 CD274

5.59e-0419852M4272
CoexpressionGSE42724_MEMORY_BCELL_VS_PLASMABLAST_UP

TRAF2 CD274

5.65e-0419952M9786
CoexpressionGSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN

IPP CD274

5.65e-0419952M8113
CoexpressionGSE17721_POLYIC_VS_PAM3CSK4_16H_BMDC_UP

TRAF2 CD274

5.71e-0420052M3842
CoexpressionGSE14769_UNSTIM_VS_240MIN_LPS_BMDM_DN

TRAF2 CD274

5.71e-0420052M3508
CoexpressionGSE44649_NAIVE_VS_ACTIVATED_CD8_TCELL_MIR155_KO_DN

CD274 KBTBD8

5.71e-0420052M9777
CoexpressionBERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP

CD274 KBTBD8

6.11e-0420752M14539
CoexpressionBLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_UP

MARCHF4 CD274

1.63e-0333952M34012
CoexpressionRIGGI_EWING_SARCOMA_PROGENITOR_UP

CD274 KBTBD8

2.68e-0343752M15981
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HMGL

CD274 KBTBD8

4.63e-0357752M39051
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_CD5_POS_CCL22_POS_MATURE_B_CELL

TRAF2 KBTBD8

6.13e-0366652M45778
CoexpressionNUYTTEN_NIPP1_TARGETS_UP

MARCHF4 KBTBD8

8.08e-0376852M6444
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

TRAF2 IPP

8.25e-0377652M1107
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN

TRAF2 IPP

8.62e-0379452MM982
CoexpressionHARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP

TRAF2 CD274

1.28e-0297352M41080
CoexpressionNUYTTEN_EZH2_TARGETS_UP

MARCHF4 KBTBD8

1.43e-02103352M4196
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-10|TCGA-Bladder / Sample_Type by Project: Shred V9

MARCHF4 CD274

8.11e-05129526a201c6344a015e5cf2f79ccf397fd7ad66b6768
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD274 KBTBD8

1.25e-0416052cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD274 KBTBD8

1.26e-04161523f3a2148c8d65e6a06f8d8116a3aa58dda17d618
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CD274 KBTBD8

1.33e-0416552d8b0a9b6f704b98e8f0412c11739879a26c036e2
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MARCHF4 CD274

1.34e-041665203a47b8687f54955e84df1edcb230db332c4ca8f
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IPP CD274

1.36e-0416752774f3264318b002d0df5d06d41d645366038d0bf
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IPP CD274

1.44e-0417252ba36581ae339191a12a6d3ead39eaf69d78be10e
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

TRAF2 CD274

1.46e-041735294f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCell10x5'-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

TRAF2 KBTBD8

1.49e-0417552d7e24ac683ff36f7ce3d1151353d3d4a6f2b63bf
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CD274 KBTBD8

1.51e-041765298176bf3c961d5262593e2d5d002836adb010e13
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IPP MARCHF4

1.53e-04177528abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MARCHF4 CD274

1.56e-041795269a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MARCHF4 CD274

1.56e-0417952479116ac65488c60104a053530830763ec1f95b2
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

IPP KBTBD8

1.56e-0417952c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MARCHF4 CD274

1.56e-04179521dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

IPP KBTBD8

1.63e-04183523cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD274 KBTBD8

1.69e-0418652d740aca5dc4240851ba7bc5988c0970d785ad0c2
ToppCellproximal-3-Hematologic-Myeloid_Dendritic_Type_1|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD274 KBTBD8

1.69e-0418652c920dffd24f051b54d8b48f801fffc928d99e135
ToppCellproximal-Hematologic-Myeloid_Dendritic_Type_1|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD274 KBTBD8

1.69e-04186524ca7f6c043874a0c536f75af5ca24c7c66725e54
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CD274 KBTBD8

1.76e-0419052e0b363f772817cfc6ab425430805c1cddcba23f0
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CD274 KBTBD8

1.78e-041915209dfad8e1fcaaf94775134796b99e4e3fbb9bf40
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD274 KBTBD8

1.78e-04191520b296404ebad0aadb75737f8c0462ec6934fc8bb
ToppCell367C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

TRAF2 CD274

1.80e-0419252e44e37e5aeba8628556020d05e1606b28e2faa4f
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CD274 KBTBD8

1.83e-0419452ef30baa19b7aa97b61dea916fc2e0f5cf49848d6
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CD274 KBTBD8

1.93e-0419952946d904a880c0e211861fcec7e120853ffade282
Drugormosil

MARCHF4 CD274

3.45e-0413552ctd:C510784
DrugNaproxen [22204-53-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A

TRAF2 IPP

6.89e-04191521706_DN
DrugPolyethylene Glycols

MARCHF4 CD274

9.96e-0423052ctd:D011092
Drugcupric oxide

IPP KBTBD8

5.41e-0354352ctd:C030973
Drugaspirin

TRAF2 CD274

5.81e-0356352CID000002244
DrugEtoposide

TRAF2 CD274

6.30e-0358752ctd:D005047
DrugE-PEG

TRAF2 CD274

7.03e-0362152CID000003310
DrugPaclitaxel

TRAF2 CD274

9.37e-0372052ctd:D017239
DrugThapsigargin

TRAF2 MARCHF4

3.13e-02135352ctd:D019284
DrugFluorouracil

TRAF2 CD274

3.18e-02136452ctd:D005472
Diseasemigraine disorder

MARCHF4 KBTBD8

1.42e-0335752MONDO_0005277

Protein segments in the cluster

PeptideGeneStartEntry
VYRCMISYGGADYKR

CD274

111

Q9NZQ7
SRYYFGCCEMQGLIY

IPP

426

Q9Y573
VYCCGKMYAIGGRVY

KBTBD8

386

Q8NFY9
CYGMYGFMDVVCIGL

MARCHF4

276

Q9P2E8
YGYKMCLRIYLNGDG

TRAF2

386

Q12933