Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpyruvate dehydrogenase (acetyl-transferring) kinase activity

PDK1 PDK4

2.97e-055352GO:0004740
GeneOntologyBiologicalProcessregulation of acetyl-CoA biosynthetic process from pyruvate

PDK1 PDK4

1.67e-054352GO:0010510
GeneOntologyBiologicalProcessregulation of acyl-CoA biosynthetic process

PDK1 PDK4

2.79e-055352GO:0050812
GeneOntologyCellularComponentmitotic spindle pole

ASPM FAM83D NSMCE1

4.64e-0543343GO:0097431
GeneOntologyCellularComponentchromosome, telomeric region

RAD51 ORC4 TEP1 NSMCE1

1.85e-04176344GO:0000781
DomainBCDHK_Adom3

PDK1 PDK4

3.21e-055342PF10436
DomainHis_kinase_dom

PDK1 PDK4

3.21e-055342IPR005467
DomainHIS_KIN

PDK1 PDK4

3.21e-055342PS50109
Domain-

PDK1 PDK4

3.21e-0553421.20.140.20
DomainBCDHK/PDK_N

PDK1 PDK4

3.21e-055342IPR018955
DomainIQ

ASPM DCAF6 MYO15A

4.27e-0481343SM00015
DomainHATPase_c

PDK1 PDK4

4.83e-0418342SM00387
DomainHATPase_c

PDK1 PDK4

5.39e-0419342PF02518
DomainIQ_motif_EF-hand-BS

ASPM DCAF6 MYO15A

5.81e-0490343IPR000048
Domain-

PDK1 PDK4

5.99e-04203423.30.565.10
DomainIQ

ASPM DCAF6 MYO15A

6.40e-0493343PS50096
DomainHATPase_C

PDK1 PDK4

6.61e-0421342IPR003594
DomainIQ

ASPM MYO15A

7.39e-0371342PF00612
Pubmed

MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein.

MAP3K1 PKD1

2.95e-06335220923779
Pubmed

Prostaglandin E₂-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells.

PTGER4 RAPGEF3

2.95e-06335223317035
Pubmed

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.

PDK1 PDK4

2.95e-06335214966024
Pubmed

ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity.

SCNN1A PKD1

5.90e-06435230952430
Pubmed

Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.

PDK1 PDK4

5.90e-06435230482839
Pubmed

Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.

PDK1 PDK4

5.90e-06435212573248
Pubmed

Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.

PDK1 PDK4

5.90e-06435225991547
Pubmed

Diversity of the pyruvate dehydrogenase kinase gene family in humans.

PDK1 PDK4

5.90e-0643527499431
Pubmed

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.

PDK1 PDK4

9.82e-06535211978179
Pubmed

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.

PDK1 PDK4

9.82e-06535211485553
Pubmed

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.

PDK1 PDK4

9.82e-06535211486000
Pubmed

Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

PTGER4 RAPGEF3

9.82e-06535228341741
Pubmed

BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.

PDK1 PDK4

1.47e-05635233773101
Pubmed

Prostaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer.

PTGER4 RAPGEF3

3.53e-05935224586238
Pubmed

FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.

RELN MAP3K1

3.53e-05935220554749
Pubmed

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.

PDK1 PDK4

6.45e-051235212676647
Pubmed

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.

ASPM RELN

1.49e-041835228272472
Pubmed

Identification and proteomic profiling of exosomes in human urine.

SCNN1A PKD1

2.04e-042135215326289
Pubmed

Fanconi Anemia

RAD51 UBE2T

2.46e-042335220301575
Pubmed

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.

ARAP3 RAPGEF3

2.46e-042335222535667
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

RAD51 ASPM XYLT2 SEMA4B UBE2T UBR4 NSMCE1

3.05e-04132735732694731
Pubmed

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.

COX6C FSIP2 RELN PDK1

3.34e-0433135429199018
Pubmed

Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells.

VPS37C UBR4

3.93e-042935225681748
Pubmed

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.

HIF3A PTGER4

3.93e-042935216966370
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

ASPM RELN

4.20e-043035219054571
Pubmed

Image-based genome-wide siRNA screen identifies selective autophagy factors.

FXR2 PDK1 PDK4

5.51e-0415935322020285
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

PTGER4 FXR2 MAP3K1 UBR4 PKD1

6.29e-0469735528298427
Pubmed

Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.

PDK1 PKD1

6.41e-043735216319116
Pubmed

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.

PDK1 PDK4

6.76e-043835220185832
Pubmed

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

RAD51 ASPM

6.76e-043835234059773
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RAD51 SEMA4B ARAP3 TEP1 UBR4 PKD1

7.48e-04110535635748872
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

SCNN1A PKD1

9.06e-044435219322198
Pubmed

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

PDK1 PDK4

9.90e-044635235237793
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

RAD51 UBE2T

2.90e-0420232548
CoexpressionGSE27896_HDAC6_KO_VS_WT_TREG_DN

XYLT2 ARAP3 PTGER4 RAPGEF3 NSMCE1

2.59e-06165355M8246
CoexpressionGSE14308_TH2_VS_INDUCED_TREG_UP

ASPM ORC4 VPS37C ARAP3 TMEM161B

6.31e-06198355M3366
CoexpressionMOOTHA_PYR

PDK1 PDK4

4.83e-058352M5871
CoexpressionSARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP

RAD51 ASPM BRIX1 UBE2T

6.97e-05166354M4288
CoexpressionRIGGI_EWING_SARCOMA_PROGENITOR_DN

ASPM FAM83D PDK1 PDK4

1.32e-04196354M13256
CoexpressionGSE21063_WT_VS_NFATC1_KO_8H_ANTI_IGM_STIM_BCELL_UP

RAD51 ASPM FAM83D UBE2T

1.40e-04199354M8277
CoexpressionGSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_DN

SCNN1A ARAP3 TEP1 FXR2

1.40e-04199354M2921
CoexpressionGSE37533_PPARG2_FOXP3_VS_FOXP3_TRANSDUCED_CD4_TCELL_UP

SIK2 HIF3A B4GALT6 RNF44

1.43e-04200354M8968
CoexpressionGSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP

PTGER4 B4GALT6 MAP3K1 NSMCE1

1.43e-04200354M9635
ToppCellLPS-IL1RA-Unknown-Endothelial-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASPM SCNN1A RELN UBE2T PKD1

4.64e-081253552938a1d62afe1e0a3abba5eb92f07b886cc0accd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51 ASPM FAM83D ARAP3 UBE2T

1.97e-07167355bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51 ASPM FAM83D UBE2T

9.18e-06169354b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAD51 ASPM FAM83D UBE2T

9.62e-0617135452fdc2a4ec36fb91583b1215362548ceb6740ae1
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAD51 ASPM FAM83D UBE2T

9.62e-06171354e3cab55f39879e2bd3e8bda91802181075839bc4
ToppCell(01)_Cycling_Basal_(homeostasis)|World / shred by cell type and Timepoint

RAD51 ASPM FAM83D UBE2T

1.10e-0517735405c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCellDividing_Macrophages-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.13e-051783541893fadac2ec3d5de0a641e57b7b2f962012a9ba
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAD51 ASPM FAM83D UBE2T

1.15e-05179354ac987c9425a1b4106d1b8779a2c5461383eae2ae
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAD51 ASPM FAM83D UBE2T

1.18e-051803545e1680088065be14447d5d5465f91f7edd071a1e
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RELN HIF3A ARAP3 PDK4

1.20e-05181354e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCellP28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.20e-05181354e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCellP28-Endothelial-proliferative_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.20e-051813542be3d44619adb25d339e7a27b500a56e07e8de01
ToppCellDividing_Macrophages-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.28e-05184354f15ce786d25c6546804a6d1efcc2ad645f2ef54e
ToppCellDividing_Macrophages-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.34e-051863540067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ASPM BRIX1 FAM83D UBE2T

1.34e-0518635486d145f965c311189e7996390eef491642417c5c
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51 ASPM FAM83D UBE2T

1.40e-0518835461ae7405ab56570409bf35382dc0a038e4137c15
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPM FAM83D FNDC1 UBE2T

1.40e-0518835495d0a796d62ce6d121e2028c378faffc14b35275
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COX6C SCNN1A PDK4 B4GALT6

1.46e-0519035468ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCellfacs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COX6C SCNN1A PDK4 B4GALT6

1.46e-05190354010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell10x5'-lymph-node_spleen-Lymphocytic_NK-Cycling_NK|lymph-node_spleen / Manually curated celltypes from each tissue

RAD51 ASPM UBE2T B4GALT6

1.46e-05190354451eaceb0cb0ec6cfcae00253c0e5c92a168c2f3
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAD51 ASPM FAM83D UBE2T

1.49e-0519135415dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCellEndothelial-D_(cycle)|World / shred on cell class and cell subclass (v4)

RAD51 ASPM FAM83D UBE2T

1.49e-0519135449a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCellEndothelial-Endothelial-D_(cycle)|Endothelial / shred on cell class and cell subclass (v4)

RAD51 ASPM FAM83D UBE2T

1.49e-05191354a3c5a913a99f17633c140ec9ece81b73e59e0715
ToppCellDividing_Macrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.49e-051913543e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.49e-05191354b978afe76754cc56e1672abca27be289bb56375b
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAD51 ASPM FAM83D UBE2T

1.49e-0519135445c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCellDividing_Macrophages-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.52e-05192354741bd0c2b0a7ce3fcb1610ce8bdacaf9a803c212
ToppCelldroplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD51 ASPM FAM83D UBE2T

1.52e-0519235496f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCellP03-Endothelial-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.58e-0519435422bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCellP03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.58e-051943545e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCell(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

RAD51 ASPM FAM83D UBE2T

1.58e-051943544d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAD51 ASPM FAM83D UBE2T

1.58e-051943543a49c7c86036e09a8cd0114988380d04ad1a26fb
ToppCellDividing_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

RAD51 ASPM FAM83D UBE2T

1.61e-0519535479ee423df85aa1631b7bdea74eacaf826dfc4a2c
ToppCellDividing_cells-Dividing_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

RAD51 ASPM FAM83D UBE2T

1.61e-0519535419829760dfcc0edafd2a2bd80f424a45d039af1f
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RAD51 ASPM FAM83D UBE2T

1.65e-0519635462b2de1d38a99ab23211bf51595845f8a1fdb7d2
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RAD51 ASPM FAM83D UBE2T

1.68e-0519735421861d8b389fafbdb7c3499684c9b6deee3dbd5e
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RAD51 ASPM FAM83D UBE2T

1.68e-051973544b13335a43b9d6abc8e542e72440da7feb82fbe6
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RAD51 ASPM UBE2T MAP3K1

1.68e-05197354196eaecef7003ed83f323c1f157c6a3594650097
ToppCellICU-SEP-Lymphocyte-T_NK-T_NK_proliferative|ICU-SEP / Disease, Lineage and Cell Type

RAD51 ASPM FAM83D UBE2T

1.68e-05197354908e91fa16134b61943aea5e8fc0d6fbac8a8c6e
ToppCell21-Trachea-RBC|Trachea / Age, Tissue, Lineage and Cell class

RAD51 ASPM FAM83D UBE2T

1.68e-051973549f8eb6305ade0654bbcd8f19963be0b64af083de
ToppCelldistal-Hematologic-Proliferating_NK/T-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.68e-0519735404b10879e48c101d1de449db0bc6b6484090b965
ToppCell21-Trachea-RBC-RBC|Trachea / Age, Tissue, Lineage and Cell class

RAD51 ASPM FAM83D UBE2T

1.68e-051973544710b55806a618076a954190f519e49c55d300d3
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic-lymphocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RAD51 ASPM FAM83D UBE2T

1.68e-05197354ffb004c37cdd26cb7cdcd80f769a2eded65416dc
ToppCellHealthy_donor-T/NK_proliferative|Healthy_donor / disease group, cell group and cell class (v2)

RAD51 ASPM FAM83D UBE2T

1.68e-05197354b6bbf87e5823fa66b4cad6a7be4f777356887b59
ToppCelldistal-Hematologic-Proliferating_NK/T-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-051983545c14b152912429f099dfcb6bcb1aec80314a3284
ToppCell(4)_B_cells-(4)_B_Hypermutation|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RAD51 ASPM FAM83D UBE2T

1.71e-051983548be724a49b4c911d68c3e82fb75e96722d0eaa03
ToppCelldistal-3-Hematologic-Proliferating_NK/T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-05198354aa23119d73554733981df474648e59918d04edfc
ToppCelldistal-1-Hematologic-Proliferating_Macrophage|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-05198354df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCelldistal-Hematologic-Proliferating_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-051983548afeb1f9bc9d8551482c8fefe4c5f88d9cd13ee2
ToppCelldistal-Hematologic-Proliferating_Macrophage-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-051983542b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

RAD51 ASPM FAM83D UBE2T

1.71e-05198354880f9817f5145f10f29fc05c5866090433532fe2
ToppCelldistal-2-Hematologic-Proliferating_NK/T|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.71e-05198354a5fd710df5669c95fc5b5ef6e5cfafe6687c7b72
ToppCellNon-neuronal-Dividing-Radial_Glia-vRG-11|World / Primary Cells by Cluster

RAD51 ASPM FAM83D UBE2T

1.71e-05198354672c6faeed54e1397e12c0aac1a5cbd19c684f06
ToppCell(0)_NK_dividing|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RAD51 ASPM FAM83D UBE2T

1.71e-05198354c5336d9b802393d6fd6f8446ea4bb6befeb97bfd
ToppCellmild_COVID-19-T/NK_proliferative|World / disease group, cell group and cell class (v2)

RAD51 ASPM FAM83D UBE2T

1.75e-05199354d44cc74d7171d96add61dae821daf774b17d4c69
ToppCellproximal-3-Epithelial-Proliferating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.75e-051993542263bb73d9c5693b44d91d2548305efc1b6e4079
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Polychromatic_Erythroblast|Megakaryocytic-erythropoietic / Lineage, cell class and subclass

RAD51 ASPM BRIX1 UBE2T

1.75e-05199354fa698f00d2dad74d28b4696c8c23dce70f123e52
ToppCellproximal-Epithelial-Proliferating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.75e-05199354521ff4ae3437c8ba477a0a42b9da195af976c3ff
ToppCellMNPs-Dividing_Macrophages|MNPs / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.75e-051993545952980d0ece5d73f3e9f340c56a38b34d2f2309
ToppCellBiopsy_Other_PF-Immune-Proliferating_T_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

RAD51 ASPM FAM83D UBE2T

1.75e-051993541d55d06e658939b78ea046553757821381eaa026
ToppCellBiopsy_Other_PF-Epithelial-Proliferating_Epithelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

RAD51 ASPM FAM83D UBE2T

1.75e-05199354d73667e2e93026d95184e24ff0bc90afd1fb74a9
ToppCelldistal-Hematologic-Proliferating_NK/T|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.75e-051993544f02e03c118744fba0dfc5e3ed6dea4041f3d089
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors|6_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.75e-05199354a99516a5760f49a69b0fe45a9b2316e393252966
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

RAD51 ASPM FAM83D UBE2T

1.75e-05199354875ee4a85dfdfcaaf61c09ed65cebafc6acbbaf0
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_IN_Progenitors|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.75e-05199354f315ec3fb6c0799668c9195f836a77fc0db2b615
ToppCellcritical-Lymphoid-NKT-proliferating|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RAD51 ASPM SCNN1A UBE2T

1.75e-051993549284956d852e434a91be892e88e06a7c71f8c583
ToppCellDividing_Macrophages|World / lung cells shred on cell class, cell subclass, sample id

RAD51 ASPM FAM83D UBE2T

1.75e-051993545c755b6876e164dc847ef7c723f850f227cf3a87
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors_nGenesUnder4k|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.75e-051993542fbf94f7858250088e0f5ce1ff51892730a13ae8
ToppCellproximal-Epithelial-Proliferating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.75e-05199354e8549b2c4152cb23548351d9cee27c3805892cd8
ToppCellTCGA-Breast-Primary_Tumor|TCGA-Breast / Sample_Type by Project: Shred V9

RAD51 ASPM FAM83D UBE2T

1.75e-0519935482f308d4b047db049fc5ce9ff60e26cf0e1255a5
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Neuronal-Ventral_Precursors|6_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354c8ea0db79b1521f8c90d0d749280c354d3907c3a
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003548f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells|GW26 / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354a854e19703dc920e48304541e2b06ed013292f3e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells|10w / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPM FAM83D FNDC1 UBE2T

1.78e-052003541fbed5967fc1922efe4a98f5760ad74fce210c52
ToppCelldistal-Hematologic-Proliferating_Macrophage|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-052003543835a8a9739b8cd5bf19c40765ef76907ac1ad38
ToppCelldistal-Hematologic-Proliferating_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-052003549c03a8da12d29618f72c429836c1d1bd84a78b12
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003544c22a1f35ff496fa6af2ab171f2936785272bc06
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354cea58274efbe7f9e3c3ef9fbb768ebfb917e21d9
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAD51 ASPM FAM83D UBE2T

1.78e-052003542afbb5b5742b956993796621fea7e0c9888754a1
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells-Neuroepithelial_cell|3m / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003542938a029fa0478be561574ace91f95c4a528b2d4
ToppCelldistal-2-Hematologic-Proliferating_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-052003540cd3b01fb7f579e5abf000adb8ec8adc7cd779c4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells|GW16 / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354008f137920cc3b599376706803c111d1d0ec17ef
ToppCellBiopsy_IPF-Epithelial-Proliferating_Epithelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

RAD51 ASPM FAM83D UBE2T

1.78e-0520035463c5402f050fdb12abab3c8b7f33d4914ae26b9b
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells-Neuroepithelial_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003540d9b8d51a7630e70e60c76c763ff82df4c559152
ToppCellmedial-Hematologic-Proliferating_NK/T-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-05200354ab1f9f99cb4a381a642a2cfb32e7f8d276c2dda4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells-Neuroepithelial_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354c865efaaaecccbf9c833d6c1cbe85809a3ec306d
ToppCell356C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RAD51 ASPM FAM83D UBE2T

1.78e-052003544462ebd5d4632788f10a93fadd2babae701c754f
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors_nGenesUnder4k|6_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003548223d2c9b9e05b1d26e3de1bc0226d175af2e7b2
ToppCellmedial-Hematologic-Proliferating_NK/T|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-05200354bfde42e00a9a6b858937de87cd19c9ed3677d954
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Stem_cells|2m / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003540675f580ccef705875854247bbfd4ee2bcf126a1
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-T/NK_proliferative|ICU-SEP / Disease, condition lineage and cell class

RAD51 ASPM FAM83D UBE2T

1.78e-05200354ae500c8b7c2162cadd31bf44ee9dc3271192cf17
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Proliferating|6_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354c784459a62bebec560e79aba83de8611457437bc
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASPM FAM83D FNDC1 UBE2T

1.78e-05200354dd5b753bb1333fa502b9d3a6d65a53a9882b2451
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Proliferating-Cycling|6_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-05200354322337a5a9cc2de1913ee9258c98ae51fb4bd6bb
ToppCellBrain_organoid-organoid_Velasco_nature-3_mon-Proliferating|3_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003549279415f5e76cb5b4e071c6582ac249b72dd694c
ToppCelldistal-3-Hematologic-Proliferating_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAD51 ASPM FAM83D UBE2T

1.78e-052003541b65c97e8123d0572d31525d6a10bc7f16857959
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003542154c976f96489d0fa7bfe6ac1cd21edcbefe735
ToppCell(0)_NK_cells-(0)_NK_dividing|(0)_NK_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

RAD51 ASPM FAM83D UBE2T

1.78e-052003541a630bb327070ffcb111ec36bd8fd4be3627ca2a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells-Neuroepithelial_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

RAD51 ASPM FAM83D UBE2T

1.78e-052003540e119c2742f2be19fde8890d1227bf277ead976f
Diseasepolycystic kidney disease (implicated_via_orthology)

XYLT2 PKD1

1.16e-0414342DOID:0080322 (implicated_via_orthology)
DiseaseLiver carcinoma

ASPM FAM83D PPP4R3C UBE2T PDK4

2.71e-04507345C2239176
DiseaseFanconi Anemia

RAD51 UBE2T

3.80e-0425342C0015625
DiseaseAcute monocytic leukemia

RAD51 UBE2T

4.12e-0426342C0023465
DiseaseMiller Dieker syndrome

RAD51 UBE2T

5.13e-0429342C0265219
DiseaseMYELODYSPLASTIC SYNDROME

RAD51 UBE2T

2.72e-0367342C3463824
Diseasestomach cancer (is_implicated_in)

TEP1 MAP3K1

3.13e-0372342DOID:10534 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
RRLHNRRTLSMFFPM

ARAP3

1371

Q8WWN8
NFRTRHLMQDLRMLM

BRIX1

71

Q8TDN6
FMLRMLASLNHIRAD

DCAF6

826

Q58WW2
MMHIAATLIQRRFRT

ASPM

2261

Q8IZT6
RQMHLARFLRMLLRL

RAD51

241

Q06609
MSRISIRMLLNQHSL

PDK1

186

Q15118
RISTRMLMNQHILIF

PDK4

166

Q16654
LRSLHMLLMLALNRV

ORC4

276

O43929
DMHFRSLRTKLLLMS

FXR2

196

P51116
RNKMHSIRNLPSMRF

MYO15A

1201

Q9UKN7
RLMRHRYLDMISRKL

FSIP2

201

Q5CZC0
LRMHRQFMRRTSLGT

PTGER4

211

P35408
AGIRSRLNHMLAMLS

FAM83D

536

Q9H4H8
RLNHMLAMLSRRTLF

FAM83D

541

Q9H4H8
RMLMTRDLDLSHARF

RELN

2211

P78509
THLILCVLRFMRRMI

PPP4R3C

551

Q6ZMV5
RMMRVSNRSLLAFIF

B4GALT6

6

Q9UBX8
LSLRQRMMHARFRNP

FNDC1

1296

Q4ZHG4
MRGLLARRLRNHMAV

COX6C

11

P09669
NHMSRRLSQMLLMFL

SLC22A25

401

Q6T423
LLVIMFLMLLRRFRS

SCNN1A

576

P37088
MTDVHRRFLQLLMTH

NSMCE1

11

Q8WV22
RLHGMLRSLLVYMLF

PKD1

3666

P98161
STHFTRMRRRLMAIA

MAP3K1

846

Q13233
LLCALRLAMMRSHLQ

TMEM161B

321

Q8NDZ6
RLAMMRSHLQAYLNL

TMEM161B

326

Q8NDZ6
IMRLTISYLRMHRLC

HIF3A

56

Q9Y2N7
HFLMDGQVRSRMLLL

SEMA4B

426

Q9NPR2
TMHSPNMRLLRSALL

SIK2

376

Q9H0K1
LNMVLRRMHRPRSCS

RAPGEF3

41

O95398
LCHLSRQQLRMAMRI

TEP1

611

Q99973
HMMPRRLSTQRYRLQ

RNF44

271

Q7L0R7
MQRASRLKRELHMLA

UBE2T

1

Q9NPD8
ALSRLISFRRHMRMH

ZNF491

251

Q8N8L2
TSNRLHMVRLMLLER

UBR4

2966

Q5T4S7
FSSMRMLSHLRRVRV

VPS37C

136

A5D8V6
ASLLRMYLRSMRDLL

XYLT2

301

Q9H1B5