Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC18A1 SLC12A8 SLC12A7

3.08e-0823815GO:0015377
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A4 SLC12A8 SLC12A7

3.12e-089814GO:0015379
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC18A1 SLC12A8 SLC12A7

5.96e-0826815GO:0015296
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC25A27 SLC12A4 SLC18A1 SLC12A8 SLC12A7

1.18e-05125816GO:0015108
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A4 SLC12A7

1.38e-0512813GO:0008519
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A6 SLC25A27 SLC12A4 SLC18A1 SLC12A8 SLC12A7

3.44e-05151816GO:0008509
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A6 SLC9A4 SLC12A4 SLC12A8 GRIK2 SLC12A7

6.04e-05167816GO:0015079
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A6 SLC25A27 SLC12A4 SLC18A1 SLC12A8 SLC12A7

6.89e-05171816GO:0015103
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC18A1 SLC12A8 SLC12A7

1.23e-04119815GO:0015294
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC12A6 SLC9A4 SLC12A4 SLC18A1 SLC12A8 SLC25A16 SLC12A7

2.00e-04296817GO:0015291
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC12A4 SLC18A1 SLC12A8 SLC12A7

3.62e-04150815GO:0015293
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 SLC9A4 SLC12A4 TSPOAP1 SLC18A1 SLC12A8 GRIK2 SLC12A7

5.92e-04465818GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A6 SLC25A27 SLC9A4 SLC12A4 TSPOAP1 SLC18A1 SLC12A8 GRIK2 SLC12A7

9.76e-04627819GO:0022890
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A6 SLC9A4 SLC12A4 SLC18A1 SLC12A8 SLC12A7

1.41e-03301816GO:0022853
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A6 SLC25A27 SLC9A4 SLC12A4 TSPOAP1 SLC18A1 SLC12A8 GRIK2 SLC12A7

1.45e-03664819GO:0008324
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

2.33e-074813GO:0140157
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A6 SLC12A4 SLC12A8 SLC12A7

2.62e-0625814GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A6 SLC12A4 SLC12A8 SLC12A7

4.21e-0628814GO:0055081
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A4 SLC12A8 SLC12A7

1.32e-0537814GO:0055075
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A6 SLC12A4 SLC12A7

1.62e-0513813GO:0072488
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

SLC12A6 SLC9A4 PPP3CC SLC12A4 SLC12A8 SLC12A7

2.03e-05142816GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

SLC12A6 SLC9A4 PPP3CC SLC12A4 SLC12A8 SLC12A7

2.03e-05142816GO:0098659
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A6 SLC12A4 SLC12A8 SLC12A7

2.21e-0542814GO:0006884
GeneOntologyBiologicalProcessimport across plasma membrane

SLC12A6 SLC9A4 PPP3CC SLC12A4 ARL6IP5 SLC12A8 SLC12A7

3.38e-05230817GO:0098739
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A6 SLC12A4 SLC12A8 SLC12A7

4.79e-0551814GO:1990573
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC12A6 SLC25A27 SLC12A4 SLC12A8 SLC12A7

7.96e-05112815GO:1902476
GeneOntologyBiologicalProcesschloride transport

SLC12A6 SLC25A27 SLC12A4 SLC12A8 SLC12A7

1.49e-04128815GO:0006821
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC12A6 SLC25A27 SLC12A4 SLC12A8 SLC12A7

1.85e-04134815GO:0098661
GeneOntologyBiologicalProcessphosphatidylinositol acyl-chain remodeling

PLA2G4D PLA2G4E

2.26e-046812GO:0036149
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC12A6 SLC25A27 SLC12A4 SLC12A8 SLC12A7

3.42e-04153815GO:0098656
GeneOntologyBiologicalProcesspantothenate metabolic process

PANK4 SLC25A16

4.20e-048812GO:0015939
GeneOntologyCellularComponentorganelle inner membrane

SLC25A27 CYP2B6 NDUFAF5 NOA1 DHODH TMEM65 UQCC1 SAMM50 PLSCR3 LBR SLC25A16

4.17e-056528111GO:0019866
GeneOntologyCellularComponentmitochondrial inner membrane

SLC25A27 CYP2B6 NDUFAF5 NOA1 DHODH TMEM65 UQCC1 SAMM50 PLSCR3 SLC25A16

9.62e-055938110GO:0005743
GeneOntologyCellularComponentmatrix side of mitochondrial inner membrane

NDUFAF5 NOA1

4.09e-048812GO:0099617
DomainKCL_cotranspt

SLC12A6 SLC12A4 SLC12A7

3.13e-074813IPR000076
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A4 SLC12A8 SLC12A7

2.26e-0622814IPR004841
DomainAA_permease

SLC12A6 SLC12A4 SLC12A8 SLC12A7

2.26e-0622814PF00324
DomainSLC12A_fam

SLC12A6 SLC12A4 SLC12A7

2.72e-067813IPR004842
DomainSLC12_C

SLC12A6 SLC12A4 SLC12A7

4.33e-068813IPR018491
DomainSLC12

SLC12A6 SLC12A4 SLC12A7

4.33e-068813PF03522
DomainKCC1

SLC12A6 SLC12A4

1.86e-052812IPR000622
Domain3HCDH

CRYL1 EHHADH

1.11e-044812PF00725
Domain3-OHacyl-CoA_DH_NAD-bd

CRYL1 EHHADH

1.11e-044812IPR006176
Domain3-OHacyl-CoA_DH_CS

CRYL1 EHHADH

1.11e-044812IPR006180
Domain3HCDH_N

CRYL1 EHHADH

1.11e-044812PF02737
Domain3HC_DH_C

CRYL1 EHHADH

1.11e-044812IPR006108
Domain3HCDH

CRYL1 EHHADH

1.11e-044812PS00067
DomainWHEP_TRS_1

MARS1 GARS1

1.84e-045812PS00762
DomainWHEP-TRS

MARS1 GARS1

1.84e-045812SM00991
DomainWHEP_TRS_2

MARS1 GARS1

1.84e-045812PS51185
DomainWHEP-TRS

MARS1 GARS1

1.84e-045812PF00458
DomainWHEP-TRS_dom

MARS1 GARS1

1.84e-045812IPR000738
Domain-

MARS1 GARS1

2.76e-0468121.10.287.10
DomainLysoPLipase_cat_dom

PLA2G4D PLA2G4E

3.85e-047812IPR002642
DomainPLA2_B

PLA2G4D PLA2G4E

3.85e-047812PF01735
DomainPLA2C

PLA2G4D PLA2G4E

3.85e-047812PS51210
DomainPLAc

PLA2G4D PLA2G4E

3.85e-047812SM00022
DomainS15_NS1_RNA-bd

MARS1 GARS1

5.11e-048812IPR009068
Domain6PGD_dom_2

CRYL1 EHHADH

8.17e-0410812IPR013328
Domain-

CRYL1 EHHADH

8.17e-04108121.10.1040.10
DomainAcyl_Trfase/lysoPLipase

PLA2G4D PLA2G4E

2.42e-0317812IPR016035
DomainIntegrin_alpha-2

ITGA11 ITGAE

2.72e-0318812IPR013649
DomainIntegrin_alpha2

ITGA11 ITGAE

2.72e-0318812PF08441
DomainIntegrin_alpha

ITGA11 ITGAE

2.72e-0318812IPR000413
DomainINTEGRIN_ALPHA

ITGA11 ITGAE

2.72e-0318812PS00242
DomainInt_alpha_beta-p

ITGA11 ITGAE

3.03e-0319812IPR013519
Domain6-PGluconate_DH_C-like

CRYL1 EHHADH

3.03e-0319812IPR008927
DomainInt_alpha

ITGA11 ITGAE

3.03e-0319812SM00191
DomainMAGE_N

MAGEA11 MAGEB10

3.36e-0320812SM01392
DomainMAGE_N

MAGEA11 MAGEB10

4.06e-0322812PF12440
DomainFG_GAP

ITGA11 ITGAE

4.06e-0322812PS51470
DomainMAGE_N

MAGEA11 MAGEB10

4.06e-0322812IPR021072
DomainFG-GAP

ITGA11 ITGAE

4.82e-0324812PF01839
DomainFG-GAP

ITGA11 ITGAE

4.82e-0324812IPR013517
DomainIntegrin_dom

ITGA11 ITGAE

5.22e-0325812IPR032695
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7

3.23e-067653M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7

3.23e-067653MM15081
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

GPHN SLC12A6 SLC12A4 SLC12A7

1.99e-09882411395011
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A6 SLC12A4 SLC12A8 SLC12A7

3.58e-09982419323993
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A4 SLC12A7

1.26e-08382311551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A4 SLC12A7

1.26e-08382315262997
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A4 SLC12A7

1.26e-08382321733850
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

UBL7 GPHN GTF2I UBR5 KLHDC3 DROSHA PSMD5 SAMM50 HNRNPD MYSM1 CDK7

1.83e-08481821128190767
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A4 SLC12A7

5.04e-08482312637262
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A6 SLC12A4 SLC12A7

7.01e-07882324393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A6 SLC12A4 SLC12A7

7.01e-07882321613606
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A6 SLC12A4 SLC12A7

7.01e-07882312386165
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

5.49e-06282234031912
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

5.49e-06282231393094
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

5.49e-06282217510708
Pubmed

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

SLC12A6 SLC12A7

5.49e-06282210347194
Pubmed

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

SLC12A6 SLC12A4

5.49e-06282231835175
Pubmed

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

SLC12A6 SLC12A4

1.64e-05382231352162
Pubmed

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.

SLC12A6 SLC12A7

1.64e-05382217133354
Pubmed

Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.

SLC12A6 SLC12A4

1.64e-05382235274823
Pubmed

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

SLC12A6 SLC12A7

1.64e-05382224089410
Pubmed

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.

SLC12A4 SLC12A8

1.64e-05382212739168
Pubmed

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

SLC12A6 SLC12A7

1.64e-05382212657561
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A6 SLC12A4 SLC12A7

1.88e-052282318391953
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

EHHADH MARS1 ARL6IP5 GARS1 SAMM50 LBR

2.14e-0523782629564676
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

GPHN SLC12A6 SLC12A4 ARL6IP5 SAMM50 LBR SLC12A7 GPAT4

2.56e-0550482834432599
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

SLC25A27 NDUFAF5 EHHADH MARS1 NOA1 GARS1 DHODH TMEM65 UQCC1 SAMM50 SLC25A16

3.47e-051047821118614015
Pubmed

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

ZBTB16 DROSHA

5.47e-05582227668799
Pubmed

Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.

PLA2G4D PLA2G4E

5.47e-05582215866882
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

PPP3CC UBR5 PSMD5 MSH2

5.50e-058782417148452
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

SLC25A27 EHHADH MARS1 NOA1 GARS1 DHODH TMEM65 UQCC1 SAMM50 SLC25A16

6.46e-05926821020877624
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

SLC25A27 RPL7L1 NDUFAF5 NOA1 GARS1 DHODH TMEM65 UQCC1 SAMM50 PLSCR3 SLC25A16

7.23e-051136821134800366
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TBCB GTF2I RPL7L1 MYO1C UBR5 MARS1 GARS1 PSMD5 MSH2 SAMM50 LBR HNRNPD

7.66e-051353821229467282
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

SLC12A6 SLC12A4 MYO1C ARL6IP5 MSH2 SAMM50 LBR SLC12A7 GPAT4 HNRNPD

8.12e-05952821038569033
Pubmed

Defining the membrane proteome of NK cells.

GTF2I MAN1A1 MYO1C UBR5 MARS1 ARL6IP5 C1QTNF3 MSH2 LBR GPAT4 FERMT3

9.24e-051168821119946888
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

MAGI1 ITGA11 SEMA5A GRIK2

9.85e-0510182418519826
Pubmed

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.

SLC12A6 SLC12A4 SAMM50 PLSCR3

1.19e-0410682433087821
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

ARL6IP5 SAMM50 LBR GPAT4

1.52e-0411382430352685
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

GTF2I FBH1 MYO1C MSH2 HNRNPD CDK7

1.57e-0434082624332808
Pubmed

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.

SLC12A6 SLC12A7

1.96e-04982214532115
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RPL7L1 NDUFAF5 MYO1C NOA1 ARL6IP5 GARS1 PANK4 UQCC1 SAMM50 LBR GPAT4 HNRNPD

1.96e-041496821232877691
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

GPHN GTF2I MYO1C DPYSL4 MSH2 HNRNPD CDK7

1.96e-0450682730890647
Pubmed

Analysis of SUMO1-conjugation at synapses.

GPHN GRIK2

2.98e-041182228598330
Pubmed

Protein Binder Toolbox for Studies of Solute Carrier Transporters.

SLC12A6 SLC12A4 SLC12A7

3.20e-045682338878854
Pubmed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

SLC12A6 SLC12A4

3.57e-041282227782176
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MAN1A1 RPL7L1 UBR5 MARS1 HS6ST2 TM9SF1 MSH2 SAMM50 LBR

3.78e-0494282931073040
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

TBCB SLC12A4 UBR5 ARL6IP5 LBR SLC12A7 GPAT4

3.94e-0456882737774976
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

GPHN ZBTB16 UBR5 HS6ST2 TM9SF1 GARS1 UQCC1 GPAT4

4.08e-0475482833060197
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

GALNT17 EHHADH PRDM16 MN1 MMD2

4.18e-0426582519240061
Pubmed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.

SLC25A27 NDUFAF5 EHHADH TMEM65 UQCC1 SAMM50

4.43e-0441382627499296
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

MAN1A1 SP140L MARS1 ARL6IP5 TMEM65 UQCC1 LBR GPAT4 HNRNPD FAM241A

5.28e-041203821029180619
Pubmed

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.

GARS1 PANK4 LBR

5.43e-046782330669930
Pubmed

Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues.

CYP2B6 EHHADH

6.45e-041682222154759
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

GTF2I MYO1C UBR5 MARS1 GARS1 PANK4 MSH2 LBR GPAT4 HNRNPD

7.41e-041257821037317656
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

GTF2I MARS1 GARS1 MSH2

8.68e-0417982436261009
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MAGI1 GTF2I RPL7L1 MYO1C UBR5 KLHDC3 MARS1 ASXL2 MSH2 LBR

8.71e-041284821017353931
Pubmed

Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

MYO1C UBR5 LBR HNRNPD CDK7

9.37e-0431782517620599
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

TBCB SCRN2 GTF2I NDUFAF5 SLC12A4 UBR5 MARS1 DHODH UQCC1 GRIK2

1.12e-031327821032694731
Pubmed

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.

UBR5 MSH2

1.12e-032182212840015
Pubmed

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.

GTF2I UBR5 MSH2

1.16e-038782324169447
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

GTF2I MARS1 GARS1 PSMD5 HNRNPD

1.18e-0333482530425250
Pubmed

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

PSMD5 MSH2 HNRNPD

1.28e-039082328978906
Pubmed

Charcot-Marie-Tooth Neuropathy Type 2 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

MARS1 GARS1

1.35e-032382220301462
Pubmed

Proteomics analysis of the estrogen receptor alpha receptosome.

FBH1 MARS1 HNRNPD

1.41e-039382320348541
Pubmed

The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.

GTF2I HNRNPD

1.47e-032482224798327
Pubmed

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

GALNT17 ADAMTS6 SI SLC12A8

1.59e-032118247566098
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

SLC25A27 SLC9A4 SLC18A1 SEMA5A

1.62e-0321282419521566
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

TBCB GTF2I LBR TASOR

1.70e-0321582435973513
Pubmed

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

MARS1 GARS1 MSH2 LBR

1.76e-0321782430619736
Pubmed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.

ITGA11 ITGAE

1.86e-032782231541017
Pubmed

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.

EHHADH SI

1.86e-032782228167773
Pubmed

Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.

HS6ST2 MMD2

1.86e-032782224496616
Pubmed

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.

GPHN MAGI1

1.99e-032882224448406
Pubmed

E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.

GTF2I MYO1C

1.99e-032882230277474
Pubmed

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

ITGA11 ITGAE

1.99e-032882218839057
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

GTF2I RPL7L1 MYO1C UBR5 MARS1 PANK4 MSH2 SAMM50 LBR HNRNPD

2.05e-031440821030833792
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

UBL7 TBCB GPHN GTF2I MARS1 GARS1 PANK4 PSMD5 MSH2 HNRNPD

2.21e-031455821022863883
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

UBL7 GTF2I UBR5 HNRNPD

2.25e-0323282425515538
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

GTF2I RPL7L1 MYO1C MARS1 GARS1 MSH2 LBR HNRNPD

2.32e-0398982836424410
InteractionTMC4 interactions

SELENOT SLC12A6 SLC12A4 SLC12A7

6.13e-0630814int:TMC4
CytobandEnsembl 112 genes in cytogenetic band chr3p14

MAGI1 ARL6IP5 TASOR

1.99e-03140813chr3p14
Cytoband8p21.3

PPP3CC SLC18A1

2.07e-03388128p21.3
GeneFamilySolute carriers

SLC12A6 SLC25A27 SLC9A4 SLC12A4 SLC18A1 SLC12A8 SLC25A16 SLC12A7

3.57e-05395588752
GeneFamilyCD molecules|Integrin alpha subunits

ITGA11 ITGAE

1.50e-03185821160
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLA2G4D PLA2G4E

1.67e-0319582832
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_IKAROS_KO_UP

SLC25A27 GTF2I PANK4 SI ITGAE SLC12A7

1.20e-05166806M7009
CoexpressionGSE29617_CTRL_VS_DAY7_TIV_FLU_VACCINE_PBMC_2008_DN

MAN1A1 FBH1 UBR5 KLHDC3 MARS1 UQCC1

2.90e-05194806M4931
CoexpressionGSE3982_NEUTROPHIL_VS_BASOPHIL_UP

SLC12A6 MAGI1 MYO1C TM9SF1 DHODH LTB

3.07e-05196806M5524
CoexpressionGSE339_CD4POS_VS_CD8POS_DC_UP

MAN1A1 MARS1 UHMK1 LTB LBR CDK7

3.44e-05200806M5108
CoexpressionGSE22432_UNTREATED_VS_TGFB1_TREATED_COMMON_DC_PROGENITOR_DN

FBH1 PPP3CC EHHADH SPNS2 RDH12 FERMT3

3.44e-05200806M7828
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_k-means-cluster#1_top-relative-expression-ranked_100

MAGEA11 C1QTNF3 MMD2 MMD2

6.00e-0631824gudmap_developingGonad_P2_testes_100_k1
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#3_top-relative-expression-ranked_100

MAGEA11 C1QTNF3 MMD2 MMD2

1.88e-0541824gudmap_developingGonad_e18.5_testes_100_k3
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#5_top-relative-expression-ranked_200

MAGEA11 C1QTNF3 MMD2 MMD2

2.07e-0542824gudmap_developingGonad_e18.5_testes_200_k5
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_500

UBL7 MAGEA11 GTF2I MYO1C HS6ST2 DPYSL4 C1QTNF3 MMD2 MMD2

2.78e-05408829gudmap_developingGonad_P2_testes_500
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_500

UBL7 MAGEA11 GTF2I MYO1C HS6ST2 C1QTNF3 MMD2 MMD2 PMM1

3.00e-05412829gudmap_developingGonad_e18.5_testes_500
CoexpressionAtlasB cells, B.Fo.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1- CD23+, Spleen, avg-3

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 SPNS2 RDH12 LTB

5.61e-05345828GSM538201_500
CoexpressionAtlasB cells, B.Fo.PC, IgD+ IgM+ CD19+ CD43- CD5- CD23+, Peritoneal Cavity, avg-3

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 SPNS2 RDH12 LTB

6.46e-05352828GSM538198_500
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_1000

UBL7 MAGEA11 ZBTB16 GTF2I MYO1C HS6ST2 DPYSL4 SEMA5A C1QTNF3 MMD2 MMD2 PMM1

6.93e-058198212gudmap_developingGonad_P2_testes_1000
CoexpressionAtlasDevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#2_top-relative-expression-ranked_1000

MAGEA11 MYO1C HS6ST2 SEMA5A MMD2 MMD2

7.23e-05181826gudmap_developingGonad_e14.5_ testes_1000_k2
CoexpressionAtlasB cells, B.T3.Sp, IgD+ IgM+ CD45R+ CD24+ CD19+ AA4.1+ CD23+, Spleen, avg-3

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 SPNS2 RDH12 LTB

7.70e-05361828GSM538219_500
CoexpressionAtlasB cells, B.FrF.BM, CD19+ IgM+ AA4.1- HSA+, Bone marrow, avg-3

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 SPNS2 RDH12 LTB

8.64e-05367828GSM399440_500
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_k-means-cluster#4_top-relative-expression-ranked_200

MAGEA11 C1QTNF3 MMD2 MMD2

1.03e-0463824gudmap_developingGonad_P2_testes_200_k4
CoexpressionAtlasDevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#2_top-relative-expression-ranked_500

MYO1C HS6ST2 C1QTNF3 MMD2 MMD2

1.44e-04129825gudmap_developingGonad_e16.5_testes_500_k2
CoexpressionAtlasDevelopingGonad_e16.5_testes_emap-8444_top-relative-expression-ranked_500

UBL7 GTF2I MYO1C HS6ST2 C1QTNF3 MMD2 MMD2 PMM1

1.82e-04409828gudmap_developingGonad_e16.5_testes_500
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_100

MAGEA11 C1QTNF3 MMD2 MMD2

2.61e-0480824gudmap_developingGonad_P2_testes_100
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_100

MAGEA11 C1QTNF3 MMD2 MMD2

3.01e-0483824gudmap_developingGonad_e18.5_testes_100
CoexpressionAtlasCD positive, CD19 Control, 19+ 4- 8-, Spleen, avg-6

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 RDH12 LTB

3.39e-04339827GSM403988_500
CoexpressionAtlasB cells, B.Fo.LN, CD19+ CD45R+ CD23+ CD21/35+, Lymph Node, avg-2

SLC12A6 MAN1A1 PPP3CC MYO1C SPNS2 RDH12 LTB

3.39e-04339827GSM777019_500
CoexpressionAtlasB cells, B.Fo.MLN, CD19+ CD45R+ CD23+ CD21/35+, Lymph Node, avg-3

SLC12A6 MAN1A1 PPP3CC MYO1C ADAMTS6 RDH12 LTB

3.57e-04342827GSM777021_500
CoexpressionAtlasDevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_200

MAGEA11 MYO1C C1QTNF3 MMD2 MMD2

4.01e-04161825gudmap_developingGonad_P2_testes_200
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_top-relative-expression-ranked_200

MAGEA11 MYO1C C1QTNF3 MMD2 MMD2

4.62e-04166825gudmap_developingGonad_e18.5_testes_200
CoexpressionAtlasDevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#3_top-relative-expression-ranked_500

MAGEA11 C1QTNF3 MMD2 MMD2

4.84e-0494824gudmap_developingGonad_e18.5_testes_500_k3
CoexpressionAtlasDevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#5_top-relative-expression-ranked_500

MYO1C HS6ST2 MMD2 MMD2

5.66e-0498824gudmap_developingGonad_e14.5_ testes_500_k5
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A1 EHHADH HS6ST2 C1QTNF3 UROC1

1.24e-051628256972d45f4bd4b6522bf93295f7e9dca7c6cba1f3
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A1 EHHADH HS6ST2 C1QTNF3 UROC1

1.48e-0516882535ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

MAGI1 SEMA5A SLC12A8 PRDM16 CNTN6

2.41e-0518682509d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 MYO1C SEMA5A SLC12A8 CNTN6

2.48e-05187825d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 HS6ST2 DPYSL4 SEMA5A MMD2

2.54e-05188825842982de2197770f999a70083ed9fca40ac22d79
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 HS6ST2 DPYSL4 SEMA5A MMD2

2.54e-05188825a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCellfacs-Marrow-KLS-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GTF2I SPNS2 MSH2 PLSCR3 MN1

2.60e-05189825533685a921a65d84107d8d33c43b4fffde019143
ToppCellfacs-Marrow-KLS-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GTF2I SPNS2 MSH2 PLSCR3 MN1

2.60e-05189825dca56ab02bf0505f9a352ff907edaef30906d854
ToppCellfacs-Marrow-KLS-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GTF2I SPNS2 MSH2 PLSCR3 MN1

2.67e-05190825a513c1e7df62c28128c932a68b252ee8f0255172
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 CYP2B6 HS6ST2 GRIK2 PRDM16

2.74e-0519182523776c7302cead3881b39127398f3b3e0d27885e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC9A4 GALNT17 MAN1A1 PRDM16 FAM241A

2.81e-0519282540f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GTF2I SPNS2 MSH2 PLSCR3 MN1

2.81e-0519282503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 CYP2B6 SPNS2 GRIK2 PRDM16

3.02e-05195825dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI1 CYP2B6 HS6ST2 GRIK2 CNTN6

3.25e-051988251408e02e053ad3406229bfe8189da03be6366e81
DrugPotassium Chloride

SLC12A6 SLC12A4 SLC12A7

8.61e-076813DB00761
DrugTn 5

GPHN EHHADH KLHDC3 DHODH C1QTNF3 SAMM50 UROC1

3.52e-06179817CID006852148
Drugacrylamide

EHHADH DHODH SI HNRNPD

8.98e-0637814CID000006579
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

1.25e-052812ctd:C095651
DrugBumetanide

SLC12A6 SLC12A4 SLC12A7

2.35e-0516813ctd:D002034
Drugfenvalerate

CYP2B6 PPP3CC MARS1 DROSHA ARL6IP5

2.39e-0596815CID000003347
DiseaseBipolar Disorder

SLC12A6 MAGI1 PPP3CC SLC18A1 EHHADH GRIK2 CNTN6

2.94e-04477797C0005586
Diseasemean corpuscular hemoglobin concentration

SLC9A4 ZBTB16 UBR5 GARS1 YDJC ASXL2 LBR SLC12A7 PRDM16 MN1

7.21e-0411057910EFO_0004528
DiseaseCharcot-Marie-Tooth disease type 2

MARS1 GARS1

9.38e-0417792cv:C0270914
Diseaseschizophrenia (is_implicated_in)

SLC25A27 PPP3CC SLC18A1

1.22e-0378793DOID:5419 (is_implicated_in)
Diseaseselenium measurement, response to dietary selenium supplementation

SLC18A1 CNTN6

1.30e-0320792EFO_0006331, EFO_0600021
Diseasebasophil count

PADI4 SLC9A4 ZBTB16 TSPOAP1 EHHADH MARS1

1.89e-03483796EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
SGRGKIAMVDPFFRG

CYP2B6

96

P20813
IAMVDPFFRGYGVIF

CYP2B6

101

P20813
GEEGIFYKVPGRMGV

ASXL2

66

Q76L83
GFFNDSLPRGGYMEV

ADAMTS6

721

Q9UKP5
KEGGFFGFYRGLMPT

SLC25A16

181

P16260
FGFYRGLMPTILGMA

SLC25A16

186

P16260
PFRAGDVITVFGGMD

TSPOAP1

1791

O95153
FGRVFMKPGLPTTFA

GPHN

596

Q9NQX3
DLEFGGVPGVFLIMF

LBR

206

Q14739
IKRVMGPDFGYVTRG

PADI4

381

Q9UM07
YMVAPSIRKFFAGGV

RDH12

16

Q96NR8
LGMVFFKSDGRIPFA

MMD2

221

Q8IY49
MGVYAGREHFLFGEP

MAGEA11

341

P43364
GLYDGIEHFMFGEPR

MAGEB10

231

Q96LZ2
IVKGPMGFGFTIADS

MAGI1

646

Q96QZ7
LYIFTGDGGMAGDPF

HHIPL1

326

Q96JK4
EFGFKMGPFRVSDLA

EHHADH

511

Q08426
FLPVLEGEQMGSYFG

ITGAE

501

P38570
GPFLMVGDAAGDIYT

FBXW12

201

Q6X9E4
LIDYMFFEKRGGAGP

PLSCR3

276

Q9NRY6
GAPMYFNEGRERGKV

ITGA11

501

Q9UKX5
FGGFFIRGHPVTMRT

PANK4

321

Q9NVE7
FIPSELFGSEFFMGR

PLA2G4E

546

Q3MJ16
MTGRFGAPVSGVYFF

C1QTNF3

151

Q9BXJ4
DGKMFVTPGAGRFVP

DPYSL4

456

O14531
PFMVNSVLAEGKGGF

FBH1

536

Q8NFZ0
VVGYLPNGRFKEFMS

GPAT4

196

Q86UL3
GFTRMYFGERIVEPV

FAM241A

86

Q8N8J7
PELLFGARMYGVGVD

CDK7

181

P50613
MIVGEPFGGKTSAYR

DNAH7

1606

Q8WXX0
FFGEIGLLDPGMDVY

GALNT17

336

Q6IS24
GEGFGYIIMFRPVGS

CNTN6

731

Q9UQ52
FMKLGPEAFRFDGGV

MAN1A1

516

P33908
HMYVFGGRADRFGPF

KLHDC3

191

Q9BQ90
GAIFSKIFGPMASVG

HS6ST2

131

Q96MM7
EGLGMRYAFIGPLET

CRYL1

226

Q9Y2S2
LRFGGIFEYVESGPM

GRIK2

36

Q13002
FSRKFGEAIGMGFPV

GTF2I

876

P78347
RFYLGGPTSIRGFSM

SAMM50

336

Q9Y512
GSYFMISRALGPEFG

SLC12A6

251

Q9UHW9
REAKAPRMGTFIGVY

SLC12A7

111

Q9Y666
VFGVFFPAATGVMAG

SLC12A8

236

A0AV02
EVGFVRFFQGMPEKP

MSH2

16

P43246
GFGEGGDMQERFLFP

NOA1

61

Q8NC60
FVPPELFGSEFFMGR

PLA2G4D

496

Q86XP0
GVFFERFSGARKMPV

MN1

311

Q10571
YFGGFGEVESIELPM

HNRNPD

201

Q14103
FMPRFVRFLPDGGKE

DROSHA

681

Q9NRR4
IVGKDPFAFFGMQAP

SELENOT

101

P62341
VGFLKEMGTPGYRGE

RPL7L1

231

Q6DKI1
PSRSVFKPFIFGMGV

SCRN2

311

Q96FV2
FGGVMVFVFGITFPL

ARL6IP5

116

O75915
IASIAEKYFGPGFMG

PRDM16

696

Q9HAZ2
VSFNLMFKTFIGPGG

GARS1

276

P41250
GLYKMGFGFVEIGSV

DHODH

106

Q02127
EGGYFMPTRPFFENI

SLC9A4

141

Q6AI14
FMVAAPIFGYLGDRF

SPNS2

151

Q8IVW8
RTVGGILDFYMFLGP

SI

1186

P14410
YILKPDGVFIGAMFG

NDUFAF5

176

Q5TEU4
FSRGGMISFDVFPEG

PMM1

181

Q92871
FTPMEFEIKGGYARS

SP140L

336

Q9H930
YFMISRSLGPEFGGA

SLC12A4

186

Q9UP95
GGELYAATAMDFPGR

SEMA5A

176

Q13591
FGSGKREFIMFPYDS

TASOR

566

Q9UK61
FFDLMKLFEVGGSPS

PPP3CC

91

P48454
MDFSTYGGLLPQGFI

ZBTB16

366

Q05516
HIMGDIFSQGFGPFR

UROC1

436

Q96N76
RGTVMYVGLTDFKPG

TBCB

176

Q99426
SYRDMPGGFLFEGLS

UBL7

216

Q96S82
VQGEGFMSLYKGFLP

SLC25A27

281

O95847
SLLGPEGFFLGKMGF

YDJC

81

A8MPS7
EGFFLGKMGFREAVA

YDJC

86

A8MPS7
PDFGISYVMVRFKGS

FERMT3

551

Q86UX7
GAFTKIIEAMGFTGP

UQCC1

91

Q9NVA1
MFPLIFFGGGEEDEK

TMEM65

221

Q6PI78
PGFVKFFGNLAVMDS

PSMD5

271

Q16401
RAGMFVSKFFGGYVP

MARS1

656

P56192
GRMFDGKFVVATFYP

UHMK1

391

Q8TAS1
LPIRGFVGYMEESGF

TM9SF1

136

O15321
FGRVFMEDVGAEPGS

UBR5

2196

O95071
LVGAPFGSVMYEFVG

SLC18A1

241

P54219
PDMVDFARGKTFFGA

LTB

226

Q06643
YMDVQFDFKGAPVGG

MYO1C

201

O00159
SRGGAKFIGMIVSPY

MYSM1

681

Q5VVJ2