Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylserine transfer activity

OSBPL5 OSBPL8

1.43e-052762GO:0140343
GeneOntologyBiologicalProcessmulti-pass transmembrane protein insertion into ER membrane

NOMO2 NOMO3 NOMO1

3.82e-069753GO:0160063
GeneOntologyCellularComponentmulti-pass translocon complex

NOMO2 NOMO3 NOMO1

3.67e-069753GO:0160064
GeneOntologyCellularComponentER membrane insertion complex

NOMO2 NOMO3 NOMO1

1.57e-0514753GO:0072379
GeneOntologyCellularComponentmuscle tendon junction

NRAP ITGA7

1.89e-046752GO:0005927
MousePhenoperiorbital edema

PTPN14 NFATC3 NFKBIZ

2.84e-068533MP:0001788
MousePhenoabnormal periorbital region morphology

PTPN14 NFATC3 NFKBIZ

6.06e-0610533MP:0030038
DomainDUF2012

NOMO2 NOMO3 NOMO1

2.58e-074763PF09430
DomainDUF2012

NOMO2 NOMO3 NOMO1

2.58e-074763IPR019008
DomainCarb-bd-like_fold

NOMO2 NOMO3 NOMO1

3.57e-068763IPR013784
DomainOxysterol-bd

OSBPL5 OSBPL9 OSBPL8

1.39e-0512763IPR000648
DomainOxysterol-bd_CS

OSBPL5 OSBPL9 OSBPL8

1.39e-0512763IPR018494
DomainOxysterol_BP

OSBPL5 OSBPL9 OSBPL8

1.39e-0512763PF01237
DomainOSBP

OSBPL5 OSBPL9 OSBPL8

1.39e-0512763PS01013
DomainCarboxyPept_regulatory_dom

NOMO2 NOMO3 NOMO1

1.80e-0513763IPR014766
Domain-

NOMO2 NOMO3 NOMO1

1.80e-05137632.60.40.1120
DomainCarboxyPept-like_regulatory

NOMO2 NOMO3 NOMO1

4.23e-0517763IPR008969
DomainNFAT

NFATC2 NFATC3

1.62e-045762IPR008366
DomainPH

PRKD3 PLEKHH1 OSBPL5 OSBPL9 OSBPL8 PSD4

3.40e-04229766PF00169
DomainRHD_dimer

NFATC2 NFATC3

7.20e-0410762IPR032397
DomainRHD_dimer

NFATC2 NFATC3

7.20e-0410762PF16179
DomainNFkB/Dor

NFATC2 NFATC3

7.20e-0410762IPR000451
DomainREL_1

NFATC2 NFATC3

7.20e-0410762PS01204
DomainRHD_DNA_bind_dom

NFATC2 NFATC3

7.20e-0410762IPR011539
DomainRHD_DNA_bind

NFATC2 NFATC3

7.20e-0410762PF00554
DomainREL_2

NFATC2 NFATC3

7.20e-0410762PS50254
Domain-

NFATC2 NFATC3

7.20e-04107622.60.40.340
DomainPH

PRKD3 PLEKHH1 OSBPL5 OSBPL9 OSBPL8 PSD4

9.42e-04278766SM00233
DomainPH_DOMAIN

PRKD3 PLEKHH1 OSBPL5 OSBPL9 OSBPL8 PSD4

9.59e-04279766PS50003
DomainPH_domain

PRKD3 PLEKHH1 OSBPL5 OSBPL9 OSBPL8 PSD4

9.77e-04280766IPR001849
Domain-

PRKD3 PLEKHH1 PTPN14 OSBPL5 OSBPL9 OSBPL8 PSD4

1.06e-033917672.30.29.30
DomainPH_dom-like

PRKD3 PLEKHH1 PTPN14 OSBPL5 OSBPL9 OSBPL8 PSD4

1.73e-03426767IPR011993
DomainEGF-like_dom

MASP1 NRXN1 LAMA3 LTBP1 PTGS2

3.46e-03249765IPR000742
DomainEGF_1

MASP1 NRXN1 LAMA3 LTBP1 PTGS2

3.83e-03255765PS00022
DomainEGF-like_CS

MASP1 NRXN1 LAMA3 LTBP1 PTGS2

4.23e-03261765IPR013032
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

NFATC2 NFATC3 PTGS2

5.80e-0519573M47543
Pubmed

Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.

NOMO2 NOMO3 NOMO1

1.00e-08376336011023
Pubmed

Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.

NOMO2 NOMO3 NOMO1

1.00e-08376325576386
Pubmed

Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.

NOMO2 NOMO3 NOMO1

4.00e-08476331833031
Pubmed

A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.

NOMO2 NOMO3 NOMO1

4.00e-0847639267806
Pubmed

Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells.

NFATC2 NFATC3 PTGS2

3.49e-07776318097055
Pubmed

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

NOMO2 NOMO3 NOMO1

5.57e-07876315257293
Pubmed

Substrate-driven assembly of a translocon for multipass membrane proteins.

NOMO2 NOMO3 NOMO1

8.34e-07976336261522
Pubmed

The OSBP-related protein family in humans.

OSBPL5 OSBPL9 OSBPL8

1.63e-061176311483621
Pubmed

An ER translocon for multi-pass membrane protein biogenesis.

NOMO2 NOMO3 NOMO1

1.63e-061176332820719
Pubmed

A family of 12 human genes containing oxysterol-binding domains.

OSBPL5 OSBPL9 OSBPL8

2.17e-061276311735225
Pubmed

An oxysterol-binding protein family identified in the mouse.

OSBPL5 OSBPL9 OSBPL8

2.17e-061276312215260
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

JPH1 BRIX1 PTPN14 ALMS1 GTF3C2 VPS13C PRDX3 RRP12 OSBPL9 OSBPL8 DHX57 ZDBF2 MCUB ATL1

3.94e-061496761432877691
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

JPH1 ATXN2L ABLIM1 ALMS1 NOMO2 VPS13C SUGP1 OSBPL8 ZDBF2 ATL1

4.44e-06733761034672954
Pubmed

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

NRXN1 NOMO2 NOMO3 ATL1 NOMO1

4.46e-0611076527889896
Pubmed

ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.

CD44 ADAM10

4.71e-06276218971959
Pubmed

Simvastatin inhibits CD44 fragmentation in chondrocytes.

CD44 ADAM10

4.71e-06276227242325
Pubmed

INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.

OSBPL5 OSBPL8

4.71e-06276226206935
Pubmed

CD44-mediated cyclooxygenase-2 expression and thromboxane A2 production in RAW 264.7 macrophages.

CD44 PTGS2

4.71e-06276211713902
Pubmed

Dynamic response diversity of NFAT isoforms in individual living cells.

NFATC2 NFATC3

4.71e-06276223219532
Pubmed

The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma.

CD44 PTGS2

4.71e-06276219816074
Pubmed

Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis.

CD44 PTGS2

4.71e-06276219277703
Pubmed

A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.

NFATC2 NFATC3

4.71e-06276216051745
Pubmed

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals.

NFATC2 NFATC3

4.71e-06276227863227
Pubmed

Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments.

OSBPL5 OSBPL8

4.71e-06276229748134
Pubmed

ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function.

OSBPL5 OSBPL8

4.71e-06276227113756
Pubmed

NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.

NFATC2 PTGS2

4.71e-06276216505480
Pubmed

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane.

OSBPL5 OSBPL8

4.71e-06276228970484
Pubmed

Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2.

PRDX3 PTGS2

4.71e-06276218077825
Pubmed

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells.

NFATC2 NFATC3

4.71e-06276215657288
Pubmed

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

NFATC2 NFATC3

4.71e-0627629846484
Pubmed

Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.

NFATC2 NFATC3

4.71e-06276226374065
Pubmed

Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.

NFATC2 NFATC3

4.71e-0627629498773
Pubmed

Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.

NFATC2 NFATC3

4.71e-06276225818645
Pubmed

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

ABLIM1 NSF GRIN2B

7.99e-061876319455133
Pubmed

PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.

OSBPL5 OSBPL8

1.41e-05376229472386
Pubmed

Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.

NFATC2 PTGS2

1.41e-05376223105117
Pubmed

NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.

NFATC2 NFATC3

1.41e-0537627650004
Pubmed

NFAT transcription factors are essential and redundant actors for leukemia initiating potential in T-cell acute lymphoblastic leukemia.

NFATC2 NFATC3

1.41e-05376234234374
Pubmed

Adam10 haploinsufficiency causes freckle-like macules in Hairless mice.

CD44 ADAM10

1.41e-05376222834956
Pubmed

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

CD44 ADAM10

1.41e-05376212629514
Pubmed

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells.

NFATC2 NFATC3

1.41e-05376211740499
Pubmed

Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10.

CD44 ADAM10

1.41e-05376216390331
Pubmed

Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE.

CD44 PTGS2

1.41e-05376219246453
Pubmed

B cell hyperresponsiveness and expansion of mature follicular B cells but not of marginal zone B cells in NFATc2/c3 double-deficient mice.

NFATC2 NFATC3

1.41e-05376215814705
Pubmed

Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.

NFATC2 NFATC3

1.41e-05376217082579
Pubmed

Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion.

CD44 PTGS2

1.41e-05376212393872
Pubmed

[Expression of P53, COX2 and CD44V6 in early-stage squamous carcinoma of cervix with lymph vascular space invasion positive and negative and its relationship with prognosis].

CD44 PTGS2

1.41e-05376220193563
Pubmed

Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism.

CD44 PTGS2

1.41e-05376222038822
Pubmed

Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.

CD44 ADAM10

1.41e-05376219826051
Pubmed

Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2.

NFATC2 PTGS2

1.41e-05376215632146
Pubmed

Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.

NFATC2 NFATC3

1.41e-0537629388475
Pubmed

LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ.

NRXN1 LRRTM4

1.41e-05376231995730
Pubmed

Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.

CD44 ADAM10

1.41e-05376222923171
Pubmed

The transcription factor NFAT4 is involved in the generation and survival of T cells.

NFATC2 NFATC3

1.41e-0537629768749
Pubmed

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.

NFATC3 PTGS2

1.41e-05376221642596
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

JPH1 PRKD3 VPS13C OSBPL9 OSBPL8 FLCN DHX57 ATL1

1.46e-0550476834432599
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

NOMO2 VPS13C CD44 NOMO3 NOMO1

2.43e-0515676530409884
Pubmed

Alternative splicing and expression of human and mouse NFAT genes.

NFATC2 NFATC3

2.82e-05476218675896
Pubmed

Transcription factors of the NFAT family: regulation and function.

NFATC2 NFATC3

2.82e-0547629143705
Pubmed

Sequential involvement of NFAT and Egr transcription factors in FasL regulation.

NFATC2 NFATC3

2.82e-05476210755616
Pubmed

Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.

NFATC2 NFATC3

2.82e-05476225918731
Pubmed

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.

NFATC2 NFATC3

2.82e-0547629660947
Pubmed

NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.

NFATC2 NFATC3

2.82e-05476226527057
Pubmed

Normal B-1a cell development requires B cell-intrinsic NFATc1 activity.

NFATC2 NFATC3

2.82e-05476214595020
Pubmed

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells.

NFATC2 NFATC3

2.82e-05476216260021
Pubmed

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.

NFATC2 NFATC3

2.82e-05476222991461
Pubmed

The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis.

NFATC2 NFATC3

2.82e-05476224970700
Pubmed

Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response.

NFATC2 NFATC3

2.82e-05476238457343
Pubmed

Defective T cell development and function in calcineurin A beta -deficient mice.

NFATC2 NFATC3

2.82e-05476212091710
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

JPH1 PRKD3 CNNM4 GPR50 WDR11 NOMO2 OSBPL9 OSBPL8 NOMO3 NOMO1

4.20e-05952761038569033
Pubmed

Hepatic lipase maturation: a partial proteome of interacting factors.

NOMO2 NOMO3 NOMO1

4.31e-053176319136429
Pubmed

Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.

NFATC2 NFATC3

4.69e-05576217693409
Pubmed

Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1.

NFATC2 NFATC3

4.69e-05576222593154
Pubmed

Calcineurin B1 is essential for positive but not negative selection during thymocyte development.

NFATC2 NFATC3

4.69e-05576215030770
Pubmed

Selective role of NFATc3 in positive selection of thymocytes.

NFATC2 NFATC3

4.69e-05576217579027
Pubmed

NFAT: ubiquitous regulator of cell differentiation and adaptation.

NFATC2 NFATC3

4.69e-05576211877454
Pubmed

Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.

NFATC2 NFATC3

4.69e-0557627999066
Pubmed

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.

NFATC2 NFATC3

4.69e-05576210089876
Pubmed

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

NFATC3 NOMO2 NOMO3 NOMO1

5.08e-059276410493829
Pubmed

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

NOMO2 NOMO3 NOMO1

5.22e-053376330783098
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ABCA2 NOMO2 PRDX3 RRP12 CD44 OSBPL9 FLCN LTBP1 ITGA7 ADAM10 NOMO1

5.83e-051201761135696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ATXN2L ABLIM1 RRP12 CD44 OSBPL8 ZNF205 MCUB ADAM10 ZFP82 ATL1 RNF111

5.92e-051203761129180619
Pubmed

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

NFATC2 NFATC3

7.03e-0567629017603
Pubmed

Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.

NFATC2 NFATC3

7.03e-05676224352425
Pubmed

A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.

NFATC2 NFATC3

7.03e-05676216141075
Pubmed

Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.

NFATC2 NFATC3

7.03e-05676218676376
Pubmed

Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.

NFATC2 NFATC3

7.03e-0567628814265
Pubmed

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.

NFATC2 NFATC3

7.03e-05676212788643
Pubmed

The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.

NFATC2 NFATC3

7.03e-05676225728138
Pubmed

Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.

NFATC2 NFATC3

7.03e-05676216690925
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

TTLL12 BRIX1 ABLIM1 CD44 OSBPL9 OSBPL8 CDK7

7.91e-0547276738943005
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PRKD3 NFATC2 NFATC3

8.01e-053876312482669
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

JPH1 TTLL12 BRIX1 PTPN14 GTF3C2 WDR11 NOMO2 NSF RRP12 OSBPL8 NOMO1 PM20D2

8.78e-051487761233957083
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

METAP1 ABLIM1 GTF3C2 NFATC2 WDR11 NSF RRP12 OSBPL8 DHX57 TACSTD2 NOMO1 CDK7

9.35e-051497761231527615
Pubmed

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

NFATC2 NFATC3

9.83e-05776216554754
Pubmed

Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts.

NFATC2 NFATC3

9.83e-05776217430895
Pubmed

Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor.

LAMA3 ITGA7

9.83e-0577629004048
Pubmed

Calcium/NFAT signalling promotes early nephrogenesis.

NFATC2 NFATC3

9.83e-05776221295565
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JPH1 TTLL12 PLEKHH1 METAP1 DCHS2 ABLIM1 ABCA2 NOMO2 OSBPL8 GRIN2B RNF111

1.06e-041285761135914814
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

JPH1 PRKD3 BOC ABLIM1 NRAP ALMS1 ATXN1

1.09e-0449776723414517
Cytoband4q23

METAP1 ADH1C

5.04e-04207624q23
CytobandEnsembl 112 genes in cytogenetic band chr2p22

PRKD3 DHX57 LTBP1

7.04e-04104763chr2p22
CytobandEnsembl 112 genes in cytogenetic band chr4q23

METAP1 ADH1C

1.73e-0337762chr4q23
GeneFamilyOxysterol binding proteins|Pleckstrin homology domain containing

OSBPL5 OSBPL9 OSBPL8

4.57e-0612513670
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PRKD3 PLEKHH1 OSBPL5 OSBPL9 OSBPL8 PSD4

2.39e-05206516682
GeneFamilyNuclear factors of activated T-cells

NFATC2 NFATC3

7.76e-055512665
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL

ABCA2 PTPN14 ATXN1 NOMO2 SNX18 NFKBIZ PTGS2 NOMO3 NOMO1

8.89e-07355769M45758
CoexpressionLEE_LIVER_CANCER_HEPATOBLAST

CD44 LAMA3 PTGS2

1.28e-0516763M13123
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BOC HOXA11 DCHS2 SNX18 MKX ATL1

8.69e-07189766f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADGB MASP1 NFATC2 TACSTD2 PTGS2

3.39e-06134765657ad905b40ec3f82acdef824431b8276d291ef7
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MASP1 NRAP GPR50 ENPP3

8.34e-0675764574ed1836f6bf5fa38a53af0a05fa4437f68f36b
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MASP1 NRAP GPR50 ENPP3

8.34e-067576445f7861bfeb1c6371b73cf2ea527801342e534bc
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

BOC LRRTM4 OSBPL9 LTBP1 ITGA7

1.31e-05177765b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGB NRXN1 VWA3B DTHD1 CFAP65

1.39e-051797655e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellnormal_Lymph_Node-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

BOC ATXN1 ZNF205 DTHD1 TACSTD2

1.46e-051817657e12030965881b023f0d3d27d934fa648e2cc523
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ATXN2L ITGA7 NOMO3 RNF111 PSD4

1.67e-0518676576cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BOC ABCA2 ZNF555 NSF ADH1C

1.71e-05187765f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABLIM1 ADAMTSL1 PTPN14 LAMA3 TACSTD2

1.75e-05188765eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellClub-club-5|World / Class top

ABLIM1 ENPP3 CD44 TACSTD2 PTGS2

1.75e-051887655911409108ececdb4f8112ec4bacc215e204001f
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

NOMO2 LTBP1 PTGS2 NOMO3 NOMO1

1.89e-05191765ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

NOMO2 LTBP1 PTGS2 NOMO3 NOMO1

1.94e-051927657e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHA1 ENPP3 CD44 NFKBIZ PTGS2

1.99e-05193765349b6428f211c821844b11428d53de52be8a8f05
ToppCelldistal-Hematologic-Basophil/Mast_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ENPP3 CD44 OSBPL8 NFKBIZ PTGS2

2.09e-051957654f83449fce3717518e2acbba1a4b3bea765c0bdb
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHA1 ENPP3 CD44 NFKBIZ PTGS2

2.14e-05196765102bced15ba1f2f9aafdcf07e64195b8e1b0d87c
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHA1 ENPP3 CD44 NFKBIZ PTGS2

2.14e-0519676557fd7b39611e30a68429dea1801476b0d44c6dc1
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHA1 ENPP3 CD44 NFKBIZ PTGS2

2.14e-051967654f007bff8ed7592c277d8397b054e1c799157912
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGHA1 ENPP3 CD44 NFKBIZ PTGS2

2.14e-0519676555e562be096a510f6414811238e633accd18570e
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf|Thalamus / BrainAtlas - Mouse McCarroll V32

JPH1 PLEKHH1 NRAP PKD1L1

4.07e-05112764cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)|Thalamus / BrainAtlas - Mouse McCarroll V32

JPH1 PLEKHH1 NRAP PKD1L1

4.07e-05112764999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-|Thalamus / BrainAtlas - Mouse McCarroll V32

JPH1 PLEKHH1 NRAP PKD1L1

4.07e-05112764004cd69b66c3b26b9a61f03279b48230da351574
ToppCellThalamus-Macroglia-OLIGODENDROCYTE-O1|Thalamus / BrainAtlas - Mouse McCarroll V32

JPH1 PLEKHH1 NRAP PKD1L1

4.07e-05112764502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 NRXN1 LRRTM4 GRIN2B

1.20e-04148764d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

PLEKHH1 ENGASE METAP1 ANKRA2

1.23e-0414976489705865e94360c1288ee98c5a6b381f3c6242b3
ToppCellASK454-Epithelial-Type_1|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

IGHA1 LAMA3 TACSTD2 PTGS2

1.23e-04149764078792d5272f1881757dc47daa96e87449cf5d34
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 LTBP1 ITGA7 MCUB

1.36e-041537640ef7c45cdd854c79e527006034029767f8e108b2
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGB VWA3B DTHD1 CFAP65

1.40e-041547644e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADGB VWA3B DTHD1 CFAP65

1.40e-041547647556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

ITGA7 NOMO3 RNF111 PSD4

1.43e-04155764a4ff78e2efc6fe9a513bb2b64e5848f2ce65a09f
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

ABCA2 NFATC2 IGHA1 TACSTD2

1.47e-04156764afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTLL12 CNNM4 UPRT CRAT

1.51e-04157764a93866f051472506f1468f379c0d5313e02c9731
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM4 MKX GRIN2B DTHD1

1.62e-04160764c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell343B-Myeloid-Mast_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

ENPP3 CD44 NFKBIZ PTGS2

1.62e-04160764133ecae0a894d9a0d49d58859623359096b6f030
ToppCell343B-Myeloid-Mast_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

ENPP3 CD44 NFKBIZ PTGS2

1.62e-04160764a2f09b5955602819c8978f4372130c8ef915cd07
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM4 MKX GRIN2B DTHD1

1.62e-0416076425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NRAP LTBP1 TACSTD2

1.88e-0465763c336aa3501b9576bf12ef1bbefae55fff7705662
ToppCelldroplet-Heart-4Chambers-18m-Hematologic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB NFATC2 CD44 PSD4

2.00e-04169764ea43002e74076aa03bf688c0a76c07117787d4b5
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGB MKX VWA3B DTHD1

2.00e-04169764fba841664939c771881ba97f14ef1df6635c04ff
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 CD44 OSBPL8 LTBP1

2.04e-04170764fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL1 CD44 OSBPL8 LTBP1

2.04e-0417076403044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MKX LAMA3 LTBP1 ITGA7

2.14e-041727641d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCellAT1_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.18e-041737643afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGB VWA3B DTHD1 CFAP65

2.23e-04174764b8d1c556290d188f56aeefc17f03119686945fe7
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BOC NRAP NSF ADH1C

2.23e-0417476442f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ADGB VWA3B DTHD1 CFAP65

2.23e-0417476400cf27bc23af1472a507be31fba6245a8fdd901b
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.28e-04175764bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADGB VWA3B DTHD1 CFAP65

2.28e-04175764b1369d2b74f461e6822d0c33e9b50fe0dfbceb54
ToppCellPCW_13-14-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADGB VWA3B DTHD1 CFAP65

2.28e-04175764c82ec6deb6ccdd991a69a62b6d62d5b14c803d7a
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

JPH1 NRAP LTBP1 ITGA7

2.33e-041767649df7a124ebafb0087da0cda133a394275d7bed81
ToppCellAT1_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.33e-041767644a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB CD44 ADAM10 ZFP82

2.33e-041767645e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCellAT1_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.38e-041777643128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

ABLIM1 UPRT LTBP1 MCUB

2.38e-04177764eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-2|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN14 MKX TACSTD2 NPFFR1

2.38e-041777648f0873d348f37c823294b698043319b6608b678a
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ALMS1 WDR11 LTBP1 PSD4

2.43e-041787649d575902d3dbe33437c9d4200df093a741269803
ToppCell(06)_Krt4/13+|World / shred by cell type and Timepoint

ABLIM1 CD44 TACSTD2 PTGS2

2.43e-0417876446efdf03aa1317bc600138e871509b995e773cce
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METAP1 CD44 DHX57 PSD4

2.43e-04178764ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 ADAMTSL1 OSBPL5 MKX

2.43e-04178764cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METAP1 CD44 DHX57 PSD4

2.43e-041787646c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METAP1 CD44 DHX57 PSD4

2.43e-04178764cd85dcefe94ee742db64b63e105e13532321894a
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRA2 NFATC2 LTBP1 ZFP82

2.43e-041787646bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.43e-04178764de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABLIM1 PTPN14 LAMA3 TACSTD2

2.49e-041797644f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD44 OSBPL8 NFKBIZ PTGS2

2.49e-0417976440441de2d679733ecbf2145fabc3ed65a53310eb
ToppCellAT1_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 PTPN14 LAMA3 TACSTD2

2.54e-041807642d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

ABCA2 NFATC2 OSBPL5 DTHD1

2.54e-04180764fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 OSBPL5 MKX TACSTD2

2.54e-0418076441e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHH1 BOC PTPN14 ADAM10

2.59e-041817646a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BOC MASP1 OSBPL9 LTBP1

2.59e-041817649c157de9d3403e092c907599f2a2c16db5b21131
ToppCellPericytes-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DCHS2 MASP1 LTBP1 ITGA7

2.59e-0418176435c470988a93381eefa300831aabb813fa1b90bd
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Ciliated|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ADGB VWA3B DTHD1 CFAP65

2.59e-041817648eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCellAT1-AT2_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.59e-04181764ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BOC MASP1 OSBPL9 LTBP1

2.59e-04181764eea943fdcbef0bbaa8578f3296923e874893b405
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.59e-04181764dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.65e-041827647ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

ADGB VWA3B DTHD1 CFAP65

2.65e-04182764fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 CD44 TACSTD2 PM20D2

2.65e-041827649174fb0b7ed8f721a5c513e41fd80476a9f34332
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NRAP ENPP3 PKD1L1

2.75e-0474763a53f2e1f1044f3745a1eff5ba6275c8f1fbf3ae0
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Klk6_(Klk6)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NRAP ENPP3 PKD1L1

2.75e-0474763ae547cb8bbd780b19d9c6b555c27dad932dcc753
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB BOC DTHD1 CFAP65

2.76e-04184764264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB BOC DTHD1 CFAP65

2.76e-04184764d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGB BOC DTHD1 CFAP65

2.76e-0418476422010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.76e-041847645daff849625f2f41d56615569c0ed59cd733b34c
ToppCell367C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PRKD3 MASP1 OSBPL5 MKX

2.82e-0418576425781cf68e693e97dc1885e2879ab24fa946b51e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

ABLIM1 PTPN14 LAMA3 PTGS2

2.82e-0418576432b4e68e551d435a732f253f6ad83408c759a642
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

BOC MASP1 ADAMTSL1 LTBP1

2.82e-04185764fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell15-Airway-Epithelial-Multiciliated_cell|Airway / Age, Tissue, Lineage and Cell class

ADGB VWA3B DTHD1 CFAP65

2.82e-041857640998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.82e-0418576430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.82e-041857643e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

ADGB VWA3B DTHD1 CFAP65

2.82e-0418576418a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGB VWA3B DTHD1 CFAP65

2.88e-0418676476033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN14 NFKBIZ TACSTD2 ADAM10

2.88e-041867643dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VPS13C LAMA3 GRIN2B PTGS2

2.88e-0418676423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGB VWA3B DTHD1 CFAP65

2.88e-0418676485787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ABLIM1 LAMA3 TACSTD2 PTGS2

2.94e-04187764f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

2.94e-041877649e10ed56090d82589bc457788282f664b70ace4b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

ADGB VWA3B DTHD1 CFAP65

3.00e-0418876461a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BOC ADAMTSL1 MKX LTBP1

3.00e-04188764ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCellASK454-Epithelial-Type_1|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CNNM4 ABLIM1 LAMA3 TACSTD2

3.00e-0418876413f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
DrugPromazine hydrochloride [53-60-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A

PRKD3 ABLIM1 YIPF2 GTF3C2 CD44 SUGP1 LTBP1

3.39e-061907673833_DN
DrugAmiprilose hydrochloride [60414-06-4]; Up 200; 11.8uM; PC3; HT_HG-U133A

YIPF2 ABCA2 NFATC3 RRP12 CD44 SUGP1 NPFFR1

4.17e-061967674000_UP
Drugclotrimazole; Up 200; 50uM; MCF7; HT_HG-U133A_EA

PRKD3 NFATC3 RRP12 SUGP1 LAMA3 PSD4

3.62e-05185766905_UP
Drugretinoic acid; Down 200; 1uM; HL60; HT_HG-U133A

HOXA11 ATXN2L RRP12 CD44 SUGP1 ITGA7

4.08e-051897666170_DN
DrugDipyridamole [58-32-2]; Down 200; 8uM; MCF7; HT_HG-U133A

ABCA2 ALMS1 NFATC3 RRP12 CRAT NPFFR1

4.45e-051927661517_DN
DrugNoscapine [128-62-1]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ABCA2 PTPN14 PRDX3 RRP12 ZNF205 NPFFR1

4.45e-051927662745_DN
DrugIsradipine [75695-93-1]; Down 200; 10.8uM; MCF7; HT_HG-U133A

PRKD3 ENGASE YIPF2 ABCA2 ALMS1 LAMA3

4.86e-051957665447_DN
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A

CNNM4 ABCA2 PTPN14 CD44 SUGP1 PSD4

4.86e-051957666082_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; HL60; HT_HG-U133A

TTLL12 BRIX1 ATXN2L SUGP1 ITGA7 NPFFR1

4.86e-051957666174_DN
DrugEthisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A

PRKD3 ENGASE CNNM4 ABLIM1 YIPF2 LTBP1

4.86e-051957663864_DN
DrugBenzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; HL60; HT_HG-U133A

ATXN2L ALMS1 NFATC3 RRP12 FLCN ITGA7

5.00e-051967666155_DN
Drugaspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A

ABCA2 ALMS1 CD44 SUGP1 ZNF205 NPFFR1

5.00e-051967661629_DN
DrugHydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ABCA2 ALMS1 CD44 LTBP1 ADAM10 PSD4

5.14e-051977666011_DN
DrugBendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A

PRKD3 ENGASE ABCA2 ATXN1 NFATC3 SUGP1

5.14e-051977663415_DN
DrugMeticrane [1084-65-7]; Down 200; 14.6uM; MCF7; HT_HG-U133A

PRKD3 ALMS1 SUGP1 FLCN ZNF205 MCUB

5.14e-051977661671_DN
DrugAdrenosterone [382-45-6]; Up 200; 13.4uM; PC3; HT_HG-U133A

CNNM4 ATXN2L ABCA2 RRP12 SUGP1 FLCN

5.14e-051977665045_UP
DrugTyloxapol [25301-02-4]; Down 200; 4uM; MCF7; HT_HG-U133A

PRKD3 SUGP1 ZNF205 DHX57 ADAM10 NPFFR1

5.29e-051987666452_DN
DrugGlipizide [29094-61-9]; Down 200; 9uM; MCF7; HT_HG-U133A

ALMS1 NFATC3 SUGP1 LAMA3 ADAM10 PSD4

5.29e-051987664991_DN
DrugNifurtimox [23256-30-6]; Down 200; 14uM; MCF7; HT_HG-U133A

ABCA2 ALMS1 RRP12 CD44 LAMA3 ZNF205

5.29e-051987667328_DN
DrugLevamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

PRKD3 ANKRA2 RRP12 LAMA3 LTBP1 CRAT

5.29e-051987667450_DN
DrugMetanephrine hydrochloride DL [881-95-8]; Down 200; 17.2uM; MCF7; HT_HG-U133A

ENGASE CNNM4 YIPF2 ABCA2 NFATC3 SUGP1

5.29e-051987665334_DN
DrugHymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A

YIPF2 PTPN14 NFATC3 SUGP1 ZNF205 NPFFR1

5.29e-051987665684_DN
DrugPrednicarbate [73771-04-7]; Down 200; 8.2uM; MCF7; HT_HG-U133A

ATXN2L PTPN14 ALMS1 SUGP1 ZNF205 NPFFR1

5.29e-051987663542_DN
DrugNapelline [5008-52-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

ATXN2L YIPF2 ABCA2 NFATC3 SUGP1 ITGA7

5.29e-051987664486_UP
DrugLY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

PRKD3 BRIX1 ENGASE ABCA2 SUGP1 LTBP1

5.44e-051997661054_UP
DrugCP-94,707

BOC ABCA2 PRDX3

6.88e-0524763CID000448793
DrugPEt3

NSF LAMA3 UPRT

8.79e-0526763CID000027365
Diseaseskin hydration measurement

ABLIM1 PKD1L1 DTHD1

1.95e-0521743EFO_0009586
Diseaselevel of Phosphatidylethanolamine (18:0_18:2) in blood serum

GTF3C2 ADAM10 RNF111

4.74e-0528743OBA_2045139
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ATXN2L ATXN1

4.03e-0412742DOID:1441 (implicated_via_orthology)
Diseasephosphatidylcholine 40:7 measurement

SUGP1 NOMO1

4.75e-0413742EFO_0021477
Diseaselevel of Phosphatidylethanolamine (18:1_18:1) in blood serum

ADAM10 RNF111

5.54e-0414742OBA_2045142
Diseaseschizophrenia (biomarker_via_orthology)

GRIN2B PTGS2

6.38e-0415742DOID:5419 (biomarker_via_orthology)
Diseasephosphatidylcholine 38:6 measurement

SUGP1 LTBP1

7.28e-0416742EFO_0010388
Diseasealcohol use disorder (is_implicated_in)

GRIN2B ADH1C

7.28e-0416742DOID:1574 (is_implicated_in)
Diseaselevel of Phosphatidylethanolamine (16:0_20:4) in blood serum

ADAM10 RNF111

7.28e-0416742OBA_2045137
DiseasePolyposis, Adenomatous Intestinal

CD44 PTGS2

7.28e-0416742C2713442
DiseaseFamilial Intestinal Polyposis

CD44 PTGS2

7.28e-0416742C2713443
DiseaseAdenomatous Polyposis Coli

CD44 PTGS2

8.24e-0417742C0032580
Diseaseblood metabolite measurement

ALMS1 CRAT

1.03e-0319742EFO_0005664
Diseaselevel of Phosphatidylethanolamine (18:0_20:4) in blood serum

ADAM10 RNF111

1.03e-0319742OBA_2045140
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

NRXN1 NOMO1

1.03e-0319742OBA_2045199
DiseaseDNA methylation

DCHS2 ADAMTSL1 ALMS1 NRXN1 LRRTM4 GRIN2B PTGS2

1.29e-03656747GO_0006306
DiseaseAutism Spectrum Disorders

GPR50 NRXN1 GRIN2B

1.29e-0385743C1510586
Diseaseneuropsychological test

ADAMTSL1 NRXN1 GRIN2B ATL1

1.54e-03197744EFO_0003926
Diseaselevel of Phosphatidylethanolamine (16:0_18:2) in blood serum

ADAM10 RNF111

1.65e-0324742OBA_2045136
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

CD44 NFKBIZ

1.94e-0326742C0009405
Diseasemajor depressive disorder, COVID-19

NSF CRAT

1.94e-0326742MONDO_0002009, MONDO_0100096
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

SUGP1 MCUB ADAM10 RNF111

2.12e-03215744EFO_0008317, EFO_0008591
DiseaseHereditary Nonpolyposis Colorectal Cancer

CD44 NFKBIZ

2.41e-0329742C1333990
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

METAP1 SUGP1 ADAM10 RNF111

2.46e-03224744EFO_0004574, EFO_0008317

Protein segments in the cluster

PeptideGeneStartEntry
LTPTYAQAPKHFHVP

ABLIM1

501

O14639
ALKDLQTAHYPVPFH

ADGB

816

Q8N7X0
QTAHYPVPFHDKELT

ADGB

821

Q8N7X0
QNYGSHVPPKVSHIT

ADAM10

366

O14672
KPIHHFVGVSTFSQY

ADH1C

136

P00326
HTEKPGSFYQQVLPH

ALMS1

1431

Q8TCU4
TPRYHPKSQPFVDHV

BRIX1

191

Q8TDN6
NVEVVSTPHKYPSVH

BTBD11

631

A6QL63
TKKPPTHITVVHNYQ

CRAT

196

P43155
VRHVYTPSTTKHFSP

ANKRA2

111

Q9H9E1
SPVQYAHLPHTFQFI

ATXN1

116

P54253
QSSFPQPAAVYAIHH

ATXN2L

936

Q8WWM7
ILPQVSFTAVGYHKH

NOMO3

1126

P69849
AEQVSHHPPISAFYA

OSBPL9

496

Q96SU4
PQLHLVTVYAFPFAH

NPFFR1

301

Q9GZQ6
KRSQPQHFTYHPVPA

NFATC2

666

Q13469
QHFTYHPVPAIKTEP

NFATC2

671

Q13469
SKHHSVPIAIYRSPA

NRXN1

66

P58400
ILPQVSFTAVGYHKH

NOMO2

1126

Q5JPE7
VEQQPHYTHKPTLEY

NFKBIZ

296

Q9BYH8
HTAPNVPHYAKNKAV

METAP1

301

P53582
YQSHHYSTVVPPDEI

MCUB

46

Q9NWR8
IHFYQAAHPTFPAQV

LAMA3

1131

Q16787
ITYLHNKTFHPVPNL

LRRTM4

121

Q86VH4
HQPLHVTKGYETVSP

LRRTM4

541

Q86VH4
YVSHQHPSHPQLFSI

FLCN

106

Q8NFG4
QHPHSFKYTAVTDTP

NRAP

1206

Q86VF7
YVHFTSTTHQFIPIP

CFAP65

1296

Q6ZU64
VVPQSKYSGRHHIPN

JPH1

526

Q9HDC5
HPKSATVYPKPASVH

GPR50

431

Q13585
STHVTVAPFGYLKIH

ADAMTSL1

921

Q8N6G6
GYNTPVHHPVIKSEN

MKX

181

Q8IYA7
STYSHQQVIPHVYPV

LTBP1

536

Q14766
ILPQVSFTAVGYHKH

NOMO1

1126

Q15155
QIRPHTLYVHSYKAP

PRKD3

151

O94806
FLKPTPNTVHYILTH

PTGS2

66

P35354
PNHRYTFTLKTHPSV

NSF

41

P46459
VLAKSSANVYHHPTP

HOXA11

106

P31270
FYTNVLPHSYHTPEK

OR2T35

256

Q8NGX2
NPPNFSSLSYHTHVK

DCHS2

2661

Q6V1P9
FYIAEQVSHHPPISA

OSBPL8

506

Q9BZF1
HLYHQAFPTPKSEST

ATL1

536

Q8WXF7
HLPESHPKAQVRYSV

BOC

151

Q9BWV1
TSHYPHTKESRTFIP

CD44

561

P16070
TKHLANTDVPIPTHY

ENPP3

766

O14638
YVTFKSFPGIPLHHI

CDK7

246

P50613
TNTHHKYSDPPVNFL

DHX57

426

Q6P158
HVKHYTNPSQDVTVP

IGHA1

86

P01876
SLPPHVHYKIRQNSS

ABCA2

616

Q9BZC7
HIQHPSTYPFQKPVT

DTHD1

371

Q6ZMT9
KHTTLHPQYDPNTFE

MASP1

536

P48740
RAKHPEATVPQYHAV

ITGA7

1111

Q13683
FVYFSHHTVTIPPVG

ENGASE

161

Q8NFI3
VIHHFPSIPSYNVSF

PKD1L1

471

Q8TDX9
YIAEQVSHHPPVSAF

OSBPL5

471

Q9H0X9
LHPKFVAAVHYEQPT

TACSTD2

186

P09758
LATPATHYTKKPHVF

PSD4

846

Q8NDX1
VPQLPQYHHKKTFSD

PTPN14

686

Q15678
HAPAVTQHAPYFKGT

PRDX3

61

P30048
NVSFVVPGIHPYFHI

PM20D2

356

Q8IYS1
QVYHGLLSFTVHPKP

RRP12

236

Q5JTH9
TPLKTITRFYNHPVH

CNNM4

436

Q6P4Q7
YSHAKQLPVAHRPSV

SUGP1

146

Q8IWZ8
SPITVHTGHKPYQCQ

ZNF555

161

Q8NEP9
VDYVIPHPVHAFHSQ

RNF111

681

Q6ZNA4
ISYKLVPTHTQVPVH

SNX18

296

Q96RF0
VVYPKPEQLNHAFHT

TMEM50B

46

P56557
PSTYKLIHHPDVSVQ

ZDBF2

1111

Q9HCK1
PYHNPAVTAAVQVHF

NFATC3

666

Q12968
PSYLVVPQTGFHHEK

VPS13C

696

Q709C8
PVVHPHGHIFKVYTD

TTLL12

296

Q14166
PFSIPVHFTNGTYHV

PLEKHH1

996

Q9ULM0
SVTPHQRLHFVDKPY

ZFP82

156

Q8N141
VTHQRTHTGVKPYPC

ZNF205

436

O95201
PPKARTYTETVNHHY

GTF3C2

781

Q8WUA4
PHSSTYVPVLDKHVV

VWA3B

871

Q502W6
PSIHYSPQFHKVTVA

YIPF2

151

Q9BWQ6
VYISSPHSSPAHNKL

WDR11

201

Q9BZH6
TEVHPVAPTHFGQKY

UPRT

291

Q96BW1
HSFIPEPKSSCYNTH

GRIN2B

311

Q13224