Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation protein catabolic process at synapse

USP5 EGLN1

7.27e-0514192GO:0140250
DomainEz/rad/moesin-like

EPB41L4A EPB41L4B PTPN3

1.38e-0621203IPR000798
DomainFERM_CS

EPB41L4A EPB41L4B PTPN3

2.10e-0624203IPR019747
DomainFERM_C

EPB41L4A EPB41L4B PTPN3

2.69e-0626203PF09380
DomainFERM_C

EPB41L4A EPB41L4B PTPN3

3.02e-0627203SM01196
DomainFERM_PH-like_C

EPB41L4A EPB41L4B PTPN3

3.02e-0627203IPR018980
DomainFERM_N

EPB41L4A EPB41L4B PTPN3

5.61e-0633203IPR018979
DomainFERM_N

EPB41L4A EPB41L4B PTPN3

5.61e-0633203PF09379
DomainFERM_M

EPB41L4A EPB41L4B PTPN3

1.55e-0546203PF00373
DomainFERM_central

EPB41L4A EPB41L4B PTPN3

1.87e-0549203IPR019748
DomainFERM_domain

EPB41L4A EPB41L4B PTPN3

1.87e-0549203IPR000299
Domain-

EPB41L4A EPB41L4B PTPN3

1.87e-05492031.20.80.10
DomainFERM_1

EPB41L4A EPB41L4B PTPN3

1.99e-0550203PS00660
DomainFERM_2

EPB41L4A EPB41L4B PTPN3

1.99e-0550203PS00661
DomainBand_41_domain

EPB41L4A EPB41L4B PTPN3

1.99e-0550203IPR019749
DomainB41

EPB41L4A EPB41L4B PTPN3

1.99e-0550203SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

EPB41L4A EPB41L4B PTPN3

1.99e-0550203IPR014352
DomainFERM_3

EPB41L4A EPB41L4B PTPN3

1.99e-0550203PS50057
Domainzf-RING_2

RNF38 RNF24 RNF13

2.24e-0552203PF13639
DomainUbiquitin-rel_dom

EPB41L4A EPB41L4B SACS PTPN3

3.90e-05184204IPR029071
DomainFA

EPB41L4A EPB41L4B

8.44e-0513202SM01195
DomainFERM-adjacent

EPB41L4A EPB41L4B

8.44e-0513202IPR014847
DomainFA

EPB41L4A EPB41L4B

8.44e-0513202PF08736
DomainZnf_C3HC4_RING-type

RNF38 RNF24 RNF13

7.80e-04172203IPR018957
DomainZINC_FINGER_C2H2_2

ZNF621 ZNF280B ZFP90 GTF3A ZNF790

1.12e-03775205PS50157
DomainZINC_FINGER_C2H2_1

ZNF621 ZNF280B ZFP90 GTF3A ZNF790

1.13e-03777205PS00028
Domain-

RNF38 RNF24 USP5 RNF13

1.18e-034492043.30.40.10
DomainZnf_C2H2-like

ZNF621 ZNF280B ZFP90 GTF3A ZNF790

1.26e-03796205IPR015880
DomainZnf_RING/FYVE/PHD

RNF38 RNF24 USP5 RNF13

1.28e-03459204IPR013083
DomainZnf_C2H2

ZNF621 ZNF280B ZFP90 GTF3A ZNF790

1.33e-03805205IPR007087
DomainZnF_C2H2

ZNF621 ZNF280B ZFP90 GTF3A ZNF790

1.35e-03808205SM00355
Domainzf-C3HC4

RNF38 RNF24 RNF13

1.65e-03223203PF00097
DomainZF_RING_1

RNF38 RNF24 RNF13

3.51e-03291203PS00518
DomainZF_RING_2

RNF38 RNF24 RNF13

3.75e-03298203PS50089
DomainRING

RNF38 RNF24 RNF13

4.00e-03305203SM00184
Domainzf-C2H2_6

ZNF621 ZFP90 ZNF790

4.34e-03314203PF13912
DomainZnf_RING

RNF38 RNF24 RNF13

4.82e-03326203IPR001841
Domain-

ZNF621 ZFP90 GTF3A ZNF790

5.27e-036792043.30.160.60
Domainzf-C2H2

ZNF621 ZFP90 GTF3A ZNF790

5.66e-03693204PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF621 ZFP90 GTF3A ZNF790

5.69e-03694204IPR013087
DomainKRAB

ZNF621 ZFP90 ZNF790

6.25e-03358203PS50805
DomainKRAB

ZNF621 ZFP90 ZNF790

6.25e-03358203PF01352
DomainKRAB

ZNF621 ZFP90 ZNF790

6.79e-03369203SM00349
DomainKRAB

ZNF621 ZFP90 ZNF790

6.84e-03370203IPR001909
Domain-

EPB41L4A EPB41L4B PTPN3

7.97e-033912032.30.29.30
DomainPH_dom-like

EPB41L4A EPB41L4B PTPN3

1.01e-02426203IPR011993
Pubmed

Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells.

EPB41L4A EPB41L4B

3.14e-07220210783258
Pubmed

Designing active RNF4 monomers by introducing a tryptophan: avidity towards E2∼Ub conjugates dictates the activity of ubiquitin RING E3 ligases.

RNF38 RNF13

4.71e-06620231048496
Pubmed

Cloning, characterization, and genomic structure of the mouse Ikbkap gene.

EPB41L4B PTPN3

8.78e-06820211747609
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

SACS LRP1B

2.85e-051420215082773
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

SACS LRP1B

1.54e-043220225189868
Pubmed

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

LRP1B GTF3A

5.09e-045820220935630
CytobandEnsembl 112 genes in cytogenetic band chr9q31

EPB41L4B PTPN3

1.62e-03137202chr9q31
CytobandEnsembl 112 genes in cytogenetic band chr13q12

SACS GTF3A

4.63e-03234202chr13q12
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

EPB41L4A EPB41L4B PTPN3

1.32e-05501731293
GeneFamilyRing finger proteins

RNF38 RNF24 RNF13

2.02e-0327517358
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF621 ZFP90 GTF3A ZNF790

3.88e-0371817428
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EPB41L4B PKDREJ LRP1B

4.38e-0515520377fdae85d36efb776db977eb424b32487ef222e4
ToppCellfacs-Lung-nan-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L4A EPB41L4B PTPN3

5.37e-0516620311b0ae82b3068ef91715dbdd49fe8e9791b4a480
ToppCellfacs-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPB41L4A EPB41L4B PTPN3

5.37e-05166203fcc1aec31ebd39432d4cb284dc8fadf34e3c566a
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-DC2|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PKDREJ LRP1B PTPN3

6.17e-0517420360ee7c6f1b6972e6647a16848087cc60e0060bbe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNF24 LRP1B PTPN3

6.94e-0518120322363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

LRP1B PTPN3 SLC5A12

7.06e-051822039d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RNF24 LRP1B PTPN3

7.29e-051842038fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

LRP1B PTPN3 SLC5A12

7.65e-05187203d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RNF24 EPB41L4B LRP1B

8.66e-0519520319853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RNF24 EPB41L4B LRP1B

8.66e-05195203d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MRC1 PTPN3 GTF3A

9.06e-051982037a99c341736a4a2ac48ef8e2f7951f21a7378946
Diseaseasthma, response to diisocyanate

LRP1B PTPN3 SLC5A12

5.06e-04261183EFO_0006995, MONDO_0004979
Diseasesleep quality

EPB41L4A LRP1B

2.33e-03118182EFO_0005272
DiseaseRS-warfarin measurement

LRP1B PTPN3

2.73e-03128182EFO_0803325
DiseaseCOVID-19, mortality

LRP1B SLC5A12

4.75e-03170182EFO_0004352, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
YRGHWGKSAHQCSKC

ZNF280B

451

Q86YH2
YRSCKNLWKSCVEHH

PTPN3

291

P26045
HKHTVKCSCYEGWKL

LRP1B

1231

Q9NZR2
YCCKEHQRQDWKKHK

EGLN1

41

Q9GZT9
CKHLWKCSVEHHTFF

EPB41L4A

281

Q9HCS5
CPWIKVKDTTVKYCH

SACS

2471

Q9NZJ4
CKHLWKCAVEHHAFF

EPB41L4B

351

Q9H329
KCCWRHKQCTGHIIY

PROCA1

66

Q8NCQ7
EKGCRKGWKKHHFYC

MRC1

501

P22897
CNHEFHAKCVDKWLK

RNF38

481

Q9H0F5
LGEKTSWYEVHCICK

PKDREJ

1121

Q9NTG1
AYHCKCVDPWLTKTK

RNF13

261

O43567
CKHAFHRKCLIKWLE

RNF24

96

Q9Y225
LHTGEKLYKCKECWK

ZNF621

256

Q6ZSS3
CEKCGKAYIWSSHLA

ZNF790

396

Q6PG37
YSKAWKLDAHLCKHT

GTF3A

51

Q92664
KKYKTLCWCGVQHDS

SLC5A12

551

Q1EHB4
CGHYVCHIKKEGRWV

USP5

816

P45974
LKTKHIAHWCRCHGY

YEATS2

1221

Q9ULM3
KKHHECTDCGKTFLW

ZFP90

251

Q8TF47