Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZNF717 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF66 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF83 ZNF723 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

8.46e-3014599047GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZNF717 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF516 ZNF813 ZNF66 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF83 ZNF723 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

2.86e-2914129046GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZNF717 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GZF1 ZNF493 ZBTB48 ZNF484 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF335 ZNF516 ZNF813 ZNF66 ZNF432 ZNF300 ZNF208 ZNF431 ZNF350 ZNF83 ZNF723 ZNF227 RREB1 ZNF471 ZNF623 ZNF850 ZBTB1 ZNF445

1.36e-2212449038GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZNF717 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GZF1 ZNF493 ZBTB48 ZNF484 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF335 ZNF516 ZNF813 ZNF66 ZNF432 ZNF300 ZNF208 ZNF431 ZNF350 ZNF83 ZNF723 ZNF227 RREB1 ZNF471 ZNF623 ZNF850 ZBTB1 ZNF445

2.88e-2212719038GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF729 ZNF717 ZNF845 GZF1 ZNF493 ZNF484 ZNF780A ZNF341 ZNF175 ZNF300 ZNF208 ZNF227 RREB1 ZNF850 PRDM2 ZNF445

4.34e-095669016GO:0001216
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF729 ZNF717 ZNF845 GZF1 ZNF493 ZNF484 ZNF780A ZNF175 ZNF300 ZNF208 ZNF227 RREB1 ZNF850 PRDM2 ZNF445

2.86e-085609015GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF729 ZBTB6 SALL1 GZF1 ZNF493 FEZF1 ZNF175 ZNF208 ZNF350 ZBTB1 PRDM2

2.03e-073209011GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF729 ZBTB6 SALL1 GZF1 ZNF493 FEZF1 ZNF175 ZNF208 ZNF350 ZBTB1 PRDM2

2.45e-073269011GO:0001217
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN8A SCN9A

3.11e-0514903GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN8A SCN9A

2.14e-0426903GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN8A SCN9A

2.14e-0426903GO:0031420
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC13A1 SCN2A SCN8A SCN9A SLC10A3

1.06e-03171905GO:0015081
GeneOntologyMolecularFunctionsodium channel activity

SCN2A SCN8A SCN9A

1.67e-0352903GO:0005272
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

ZNF729 ZNF717 TCEA1 ZNF845 SALL1 ZNF493 ZNF484 INHBA ZNF175 ZNF335 ZNF300 ZNF208 ZNF227 RREB1 ZNF850 NOS1 PRDM2 ZNF445

1.93e-0513908818GO:0045944
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN8A SCN9A

5.36e-0517923GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN2A SCN8A SCN9A

2.77e-0429923GO:0034706
GeneOntologyCellularComponentmicrotubule minus-end

ASPM CAMSAP2

3.97e-047922GO:0036449
HumanPhenoComplex febrile seizure

SCN2A SCN8A SCN9A

2.02e-0516183HP:0011172
HumanPhenoTalipes valgus

SCN2A SCN9A EXT1

4.74e-0521183HP:0004684
HumanPhenoFocal hemiclonic seizure

SCN2A SCN8A SCN9A

8.12e-0525183HP:0006813
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

1.17e-045182HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

1.17e-045182HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

1.17e-045182HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

1.17e-045182HP:0032823
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

1.17e-045182HP:0032906
HumanPhenoNormal interictal EEG

SCN2A SCN8A

1.75e-046182HP:0002372
HumanPhenoObsessive-compulsive trait

TRIO SCN2A SCN9A

1.89e-0433183HP:0008770
HumanPhenoGeneralized clonic seizure

SCN2A SCN8A SCN9A

2.07e-0434183HP:0011169
HumanPhenoCalcaneovalgus deformity

SCN2A SCN9A EXT1

2.07e-0434183HP:0001848
HumanPhenoDeformed tarsal bones

SCN2A SCN9A EXT1

2.26e-0435183HP:0008119
HumanPhenoLimitation of knee mobility

SCN2A SCN9A EXT1

2.26e-0435183HP:0010501
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

2.45e-047182HP:0032678
HumanPhenoSmall cerebral cortex

ZNF335 ASPM

3.26e-048182HP:0002472
HumanPhenoPhotosensitive myoclonic seizure

SCN2A SCN9A

3.26e-048182HP:0001327
HumanPhenoCyanotic episode

SCN2A SCN9A

3.26e-048182HP:0200048
HumanPhenoFocal clonic seizure

SCN2A SCN8A SCN9A

3.90e-0442183HP:0002266
Domain-

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

3.88e-4367987463.30.160.60
Domainzf-C2H2

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

9.93e-436938746PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

1.06e-426948746IPR013087
DomainZnf_C2H2-like

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF385B ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

2.07e-417968747IPR015880
DomainZnf_C2H2

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF385B ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

3.50e-418058747IPR007087
DomainZnF_C2H2

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF385B ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

4.16e-418088747SM00355
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

1.67e-407758746PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 PRDM2 ZNF445

1.88e-407778746PS00028
DomainKRAB

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZNF484 ZNF684 ZNF780A ZNF718 ZNF273 ZNF175 ZNF674 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF227 ZNF700 ZNF471 ZNF25 ZNF850 ZNF614 ZNF445

1.86e-283588729PS50805
DomainKRAB

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZNF484 ZNF684 ZNF780A ZNF718 ZNF273 ZNF175 ZNF674 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF227 ZNF700 ZNF471 ZNF25 ZNF850 ZNF614 ZNF445

4.49e-283698729SM00349
DomainKRAB

ZNF729 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZNF484 ZNF684 ZNF780A ZNF718 ZNF273 ZNF175 ZNF674 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF227 ZNF700 ZNF471 ZNF25 ZNF850 ZNF614 ZNF445

4.86e-283708729IPR001909
DomainKRAB

ZNF729 ZNF708 ZNF383 ZNF845 ZNF716 ZNF484 ZNF684 ZNF780A ZNF718 ZNF273 ZNF175 ZNF674 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF227 ZNF700 ZNF471 ZNF25 ZNF850 ZNF614 ZNF445

5.08e-273588728PF01352
Domainzf-C2H2_6

ZNF729 ZNF845 ZNF117 GZF1 ZNF493 ZBTB48 ZNF684 ZNF780A FEZF1 ZNF718 ZNF273 ZNF813 ZNF432 ZNF620 ZNF208 ZNF431 ZNF227 RREB1 ZNF700 ZNF25 ZNF850 PRDM2 ZNF445

1.68e-213148723PF13912
DomainNa_trans_cytopl

SCN2A SCN8A SCN9A

1.93e-066873PF11933
DomainNa_trans_cytopl

SCN2A SCN8A SCN9A

1.93e-066873IPR024583
DomainNa_channel_asu

SCN2A SCN8A SCN9A

1.14e-0510873IPR001696
DomainNa_trans_assoc

SCN2A SCN8A SCN9A

1.14e-0510873IPR010526
DomainNa_trans_assoc

SCN2A SCN8A SCN9A

1.14e-0510873PF06512
DomainBTB

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

3.67e-04131875PF00651
DomainCAMSAP_CH

ASPM CAMSAP2

4.44e-047872PF11971
DomainCAMSAP_CH

ASPM CAMSAP2

4.44e-047872IPR022613
DomainIQ

SCN2A SCN8A SCN9A ASPM

5.56e-0481874SM00015
DomainIQ_motif_EF-hand-BS

SCN2A SCN8A SCN9A ASPM

8.27e-0490874IPR000048
DomainBTB

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

9.10e-04160875PS50097
DomainIQ

SCN2A SCN8A SCN9A ASPM

9.35e-0493874PS50096
DomainBTB

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

1.54e-03180875SM00225
DomainBTB/POZ_dom

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

1.73e-03185875IPR000210
DomainSKP1/BTB/POZ

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

1.90e-03189875IPR011333
DomainChannel_four-helix_dom

SCN2A SCN8A SCN9A

2.38e-0357873IPR027359
Domain-

SCN2A SCN8A SCN9A

2.38e-03578731.20.120.350
DomainIQ

SCN8A SCN9A ASPM

4.44e-0371873PF00612
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF729 ZNF717 TCEA1 ZNF708 ZNF383 ZNF23 ZNF716 ZNF493 ZNF484 ZNF684 ZNF718 ZNF273 ZNF175 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF227 ZNF700 ZNF471 ZNF25 ZNF614 ZNF445

7.45e-1213876327M734
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF729 TCEA1 ZNF383 ZNF845 ZNF23 ZNF493 ZNF780A ZNF300 ZNF208 ZNF25 ZNF850 ZNF445

1.28e-047686312MM14851
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN2A SCN8A SCN9A

3.50e-0431633M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN2A SCN8A SCN9A

3.85e-0432633M27455
PathwayPID_INTEGRIN_A4B1_PATHWAY

PXN JAML ADAM28

4.22e-0433633M277
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF729 TCEA1 ZNF383 ZNF845 ZNF23 GTF3A ZNF493 ZNF780A ZNF300 ZNF208 ZNF25 ZNF850 ZNF445

4.92e-0410226313MM15436
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF708 ZNF383 ZNF845 ZNF493 ZNF684 ZNF780A ZNF718 ZNF273 ZNF813 ZNF432 ZNF620 ZNF208 ZNF227 ZNF25 ZNF614 ZNF445

3.29e-20181921637372979
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF729 ZNF493 ZNF175 ZNF300 ZNF208 ZNF25 ZNF850 ZNF445

7.25e-13499289630514
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF729 TCEA1 ZNF716 SALL1 GTF3A ZBTB48 ZNF718 ZC3H15 ZNF175 ZNF516 PXN ZNF300 ZNF208 ZNF25 ZNF623 ZNF445

3.79e-10808921620412781
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF729 ZNF716 ZNF493 ZNF718 ZNF208

1.31e-082992514563677
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF23 ZNF273 ZNF83 ZNF227

2.65e-07219247865130
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN8A SCN9A

3.56e-07692323652591
Pubmed

High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.

SLC13A1 FEZF1 SCN2A ZNF385B

1.19e-063092419401682
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN8A SCN9A

1.49e-06992316382098
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF729 ZNF493 ZNF208

2.12e-061092318588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF729 ZNF493 ZNF208

2.91e-061192315469996
Pubmed

A census of human transcription factors: function, expression and evolution.

ZNF708 ZNF23 SALL1 ZNF35 ZBTB48 ZNF273 ZC3H15 ZNF175 ZNF335 RREB1 ZNF25 PRDM2

4.99e-06908921219274049
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN8A SCN9A

5.03e-061392315123669
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF729 ZNF493 ZNF208

5.03e-061392319850934
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

6.92e-06292217805013
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

6.92e-06292235348308
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

6.92e-06292215760941
Pubmed

Sodium channel slow inactivation interferes with open channel block.

SCN8A SCN9A

6.92e-06292227174182
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

6.92e-06292218601978
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

6.92e-06292219465131
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

6.92e-06292223735284
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF729 ZNF493 ZNF208

7.96e-061592315885501
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

SALL1 MYCBP2 UBR4 ZNF516 PXN RREB1 ZBTB1 PRDM2

1.57e-0541892834709266
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

TCEA1 ZNF23 ZBTB6 GTF3A ZNF35 ZNF780A PXN ZNF25 ZBTB1 ZNF445

1.87e-05709921022988430
Pubmed

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.

ZNF432 ZNF614

2.07e-05392224280104
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN9A

2.07e-05392219284629
Pubmed

A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection.

TM9SF2 EXT1

2.07e-05392230996093
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN2A SCN8A

2.07e-05392217928448
Pubmed

SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells.

RHOB SWAP70

2.07e-05392218802007
Pubmed

Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6.

SCN2A SCN8A

2.07e-05392238514708
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN2A SCN8A

2.07e-05392232845893
Pubmed

Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.

SCN2A SCN8A

2.07e-05392216033895
Pubmed

Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons.

SCN2A SCN8A

2.07e-05392229991598
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN2A SCN8A

2.07e-05392228518218
Pubmed

Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.

SCN8A SCN9A

2.07e-05392215302875
Pubmed

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

ZBTB6 GZF1 ZBTB48 ZBTB1

2.42e-056392434351428
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZBTB6 TM9SF2 ZNF484 MYCBP2 ZNF341 UBR4 ZNF350 ZNF510 ZNF83

2.76e-0559192915231748
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

SALL1 GTF3A ZNF35 ZBTB48 SCN2A VPS35L NUBP1 REG1B SLC10A3 SLFN5 RREB1 ZNF25 DIPK2B

3.57e-051293921315342556
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN8A

4.14e-05492217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN8A

4.14e-05492235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN8A

4.14e-05492229578003
Pubmed

Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes.

ZNF35 ZNF445

4.14e-0549227814019
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN2A SCN8A

4.14e-05492221156207
Pubmed

Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes.

FEZF1 PPIP5K2

4.14e-05492226204995
Pubmed

Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression.

SCN2A SCN8A

6.89e-05592224077057
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN2A SCN9A

6.89e-0559228812438
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN8A SCN9A

6.89e-05592222875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN8A

6.89e-05592217724025
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF708 ZNF23 ZNF25

7.63e-05319232288909
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN8A SCN9A

1.03e-04692216029194
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN2A SCN8A

1.03e-04692217513486
Pubmed

The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.

ZNF117 ZNF83

1.03e-0469222505992
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN2A SCN8A

1.44e-04792225818041
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRIO MYCBP2 ZNF341 ZNF335 UBR4 ZNF516 SCN8A IPP PXN SLC10A3 ZNF614

1.63e-041105921135748872
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN8A

2.46e-04992215746173
Pubmed

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

ZNF300 ZNF350

2.46e-04992223665872
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

NWD2 TRIO ZC3H15 UBR4 SCN8A SCN9A ZNF385B

2.74e-0447592731040226
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN2A SCN8A

4.49e-041292230175250
Pubmed

The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.

FEZF1 NOS1

5.30e-041392224723342
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A SCN8A

5.30e-041392216723544
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

ZNF383 ZNF23 ZBTB6 ZNF35 ZBTB48 ZNF273 ZNF175 ZNF623 ZBTB1

5.31e-0487792920211142
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TCEA1 ZNF845 MYCBP2 ORC3 ZC3H15 ZNF516 RBM28 RREB1 EIF2A PRDM2

6.78e-041103921034189442
Pubmed

Coordinated histone modifications mediated by a CtBP co-repressor complex.

ZNF516 RREB1

7.11e-041592212700765
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

ZNF23 NWD2 GZF1 ZNF66 IPP ZNF300 SLC10A3 ZNF83 ZNF227

7.18e-0491592932393512
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

USP50 TCEA1 GTF3A ZNF493 ORC3 ASPM

8.79e-0441992628700943
Pubmed

The DNA sequence and biology of human chromosome 19.

ZNF729 ZNF780A ZNF175 ZNF208 ZNF471

9.66e-0428492515057824
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

SCN2A SCN8A

1.03e-031892237321992
Pubmed

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

SALL1 GZF1

1.15e-031992230385546
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF223 ZNF227

1.27e-032092212743021
Pubmed

Human transcription factor protein interaction networks.

MRPL39 SALL1 UBR4 ZNF516 ZNF66 RBM28 RREB1 ZNF471 ZNF850 ZBTB1 PRDM2

1.38e-031429921135140242
Pubmed

Myosin-X recruits lamellipodin to filopodia tips.

TRIO MYCBP2 UBR4

1.73e-038992336861887
Pubmed

Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry.

SCN8A NOS1

2.16e-032692210591541
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

GTF3A ZBTB48 TRIO ZNF335 UBR4 ZNF516 DTX3L

2.38e-0368992736543142
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

MYCBP2 UBR4

2.50e-032892235474067
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

RHOB SWAP70 ZNF623

2.55e-031029239734811
InteractionTRIM28 interactions

ZNF708 ZNF383 ZNF845 ZNF493 ZNF484 ZNF684 MYCBP2 ZNF780A ZNF718 ZNF273 ZNF674 UBR4 ZNF813 ZNF432 ZNF620 ZNF208 ZNF350 ZNF223 ZNF227 EIF2A ZNF471 ZNF25 ZBTB1 ZNF614 ZNF445

2.86e-0914748925int:TRIM28
InteractionNOTCH2 interactions

RHOB ZNF708 ZBTB48 ZNF780A ZNF341 ZNF335 ZNF813 ZNF431 DTX3L ZNF623 ZNF445

2.57e-064238911int:NOTCH2
Cytoband19p12

ZNF729 ZNF708 ZNF493 ZNF66 ZNF208 ZNF431 ZNF723

6.71e-109092719p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF708 ZNF493 ZNF66 ZNF208 ZNF431 ZNF723

5.71e-09122927chr19p12
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF383 ZNF845 ZNF780A ZNF175 ZNF813 ZNF432 ZNF350 ZNF223 ZNF83 ZNF227 ZNF471 ZNF850 ZNF614

7.65e-0711929213chr19q13
Cytoband3p21.32

ZNF35 ZNF445

3.96e-0559223p21.32
Cytoband7q31.32

SLC13A1 FEZF1

3.05e-04139227q31.32
Cytoband19q13.41

ZNF432 ZNF350 ZNF614

5.31e-047892319q13.41
Cytoband2q32.1

FSIP2 ZC3H15

1.67e-03309222q32.1
Cytoband3q25.1

ANKUB1 EIF2A

2.01e-03339223q25.1
CytobandXp11.3

ZNF674 DIPK2B

2.53e-0337922Xp11.3
CytobandEnsembl 112 genes in cytogenetic band chr7q31

SLC13A1 FEZF1 CPED1

2.86e-03140923chr7q31
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF717 ZNF708 ZNF383 ZNF845 ZNF23 ZNF716 ZBTB6 ZNF117 SALL1 GTF3A GZF1 ZNF493 ZNF35 ZBTB48 ZNF484 ZNF684 ZNF780A ZNF341 FEZF1 ZNF718 ZNF273 ZNF175 ZNF674 ZNF335 ZNF516 ZNF813 ZNF432 ZNF620 ZNF300 ZNF208 ZNF431 ZNF350 ZNF510 ZNF223 ZNF83 ZNF227 RREB1 ZNF700 ZNF471 ZNF25 ZNF623 ZNF850 ZBTB1 ZNF614 ZNF445

2.05e-44718784628
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN8A SCN9A

6.37e-0697831203
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ZBTB6 GZF1 ZBTB48 IPP ZBTB1

2.84e-04134785861
GeneFamilyGeneral transcription factors|Xeroderma pigmentosum complementation groups|DNA helicases|ERCC excision repair associated

TCEA1 GTF3A

5.17e-0325782565
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN8A SCN9A

3.03e-0610883DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN8A SCN9A

3.03e-0610883DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN8A SCN9A

5.53e-0612883DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SLC13A1 TRIO SCN2A SCN8A SCN9A NOS1

9.66e-06163886DOID:1826 (implicated_via_orthology)
DiseaseB Virus Infection

SCN8A SCN9A

2.63e-053882C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

2.63e-053882cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

2.63e-053882C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

2.63e-053882C0019372
Diseasevaginal discharge, Metrorrhagia

ZNF684 CPED1

5.26e-054882EFO_0009365, HP_0100608
DiseaseInsulinogenic index measurement

MYCBP2 PPIP5K2

8.74e-055882EFO_0009961
Diseaseresponse to bronchodilator, response to corticosteroid

ZNF432 ZNF614

8.74e-055882GO_0031960, GO_0097366
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

1.31e-046882C0220669
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN2A SCN9A

3.12e-049882C3502809
DiseaseEpilepsy

SCN2A SCN8A SCN9A EIF2A

3.24e-04109884C0014544
DiseaseInfantile Severe Myoclonic Epilepsy

SCN2A SCN9A

6.71e-0413882C0751122
DiseaseAutosomal recessive primary microcephaly

ZNF335 ASPM

9.00e-0415882cv:C3711387
Diseasediabetes mellitus

SALL1 MYCBP2 RREB1

1.12e-0368883EFO_0000400
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN9A

1.95e-0322882DOID:2030 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

TRIO SCN2A SCN8A

2.74e-0393883C1535926

Protein segments in the cluster

PeptideGeneStartEntry
CKKGFSQDKQCFLLS

CPED1

61

A4D0V7
AKTCKIKATFQCALG

ADAM28

436

Q9UKQ2
NFKCSICEKAFLYEK

GZF1

316

Q9H116
NACIGTSICKKFFKE

DIPK2B

61

Q9H7Y0
CLFCKDAEFKASKEI

ASPM

911

Q8IZT6
GKVNICCKKQFFVSF

INHBA

316

P08476
KKFCCEDGTTIVNFK

NWD2

1471

Q9ULI1
KQCFVVTEKGSKACR

RBM28

31

Q9NW13
EVCKSPKENKFCSFL

IPP

261

Q9Y573
SGFICPKCKKESQIF

NUBP1

231

P53384
LDKIKKTACGFCFVE

NCBP2L

71

A6PVI3
FTKGNTCFECKRNIK

FSIP2

1036

Q5CZC0
FVNKCSFGCKVELEV

SLC10A3

201

P09131
AKKVFKAACDVFCVG

NOS1

936

P29475
CAFCLKQLNKGTFKE

PXN

561

P49023
ESCFDFTLCKKNGFK

EXT1

101

Q16394
CSKVSEKGQKTCILF

DTX3L

406

Q8TDB6
GKNCKVCIFSKDGTL

EIF2A

36

Q9BY44
FKCGKTKTVQQKACA

SLC13A1

316

Q9BZW2
GKFKNTACDICGKTF

SALL1

996

Q9NSC2
GFKKTCLKACAEVSQ

GSTCD

131

Q8NEC7
DQKVCCGFFFKDDQK

CAMSAP2

1156

Q08AD1
PFKCEFCVQLFKDKT

PRDM2

1161

Q13029
NKDVIGAFKKVFACC

OR2T11

291

Q8NH01
DESCEKKFSFVCKFK

REG1B

151

P48304
ILEKCFKVFKSYCEN

ORC3

471

Q9UBD5
KSCEIKFLTFKDCDP

MRPL39

121

Q9NYK5
CGKTCLLIVFSKDEF

RHOB

16

P62745
KEKCFVTQVACFLAK

NBPF12

581

Q5TAG4
GCVFQSTEDKCIFKI

JAML

41

Q86YT9
KPKVFTCEVCGKVFN

FEZF1

256

A0PJY2
QLFGKSYKECVCKIN

SCN9A

886

Q15858
KCLLINKVDGSCKTF

MYCBP2

1101

O75592
TQTDLFTCGKCKKKN

TCEA1

256

P23193
GISFCSTLKCFVKEE

ANKUB1

66

A6NFN9
KCEECDKAFSFKSNL

ZNF845

356

Q96IR2
FCQICGKTFKAVEQL

ZBTB48

551

P10074
CSFCKSQFERKKDLE

ZNF516

176

Q92618
KCEECGKAFKQSSTL

ZNF431

261

Q8TF32
SLEKTFKCNECEKAF

ZNF35

301

P13682
TLEKSFECKECGKTF

ZNF684

266

Q5T5D7
KCEDCGKVFSVFSVL

ZNF273

291

Q14593
KCEDCGKAFKVFANL

ZNF718

396

Q3SXZ3
KECEKAFCKFSSFQI

ZNF700

651

Q9H0M5
DVFLCGKCKKQFNSL

ZNF341

51

Q9BYN7
ECKECGKAFTQSSKL

ZNF383

311

Q8NA42
EKLFKCDVCGKEFSQ

ZNF223

201

Q9UK11
LKCNKFLSKTGISEC

VPS35L

301

Q7Z3J2
QKLACDTCGKSFKFL

RREB1

1391

Q92766
KCKECGKAFNVFSSL

ZNF723

286

P0DPD5
QLFGKSYKECVCKIS

SCN2A

901

Q99250
CKECGKAFNQKITLI

ZNF620

366

Q6ZNG0
EECGKAFNCSSTLKK

ZNF716

411

A6NP11
LFGKSYKECVCKINQ

SCN8A

896

Q9UQD0
CLKCEKCTYKNEVFT

USP50

196

Q70EL3
KEKKKILFSFCEVCN

ZNF385B

26

Q569K4
EKLFECKECGKSFNR

ZNF780A

246

O75290
CEECDKAFSFKSNLK

ZNF813

301

Q6ZN06
TKEKQFVCQTCGKQF

ZBTB1

601

Q9Y2K1
CSECGKAFSTKQKLI

ZNF350

376

Q9GZX5
EKPFECKECRKTFSQ

ZNF717

811

Q9BY31
KCEECGKAFSIFSIL

ZNF708

421

P17019
KFTFNKKETCKLVCT

TM9SF2

111

Q99805
KECGKFFCQKSALIV

ZNF25

121

P17030
VGKKLFKCNECDKTF

ZNF471

201

Q9BX82
AVEKTFLCQQCGKTF

ZNF445

676

P59923
FLCQQCGKTFTRKKT

ZNF445

681

P59923
CKECGKAFSKFSILT

ZNF208

231

O43345
KCEECGKAFSKVSTL

ZNF208

286

O43345
VCSECGKAFVKKSQL

ZNF432

206

O94892
KCEECGKTFSVFSIL

ZNF493

306

Q6ZR52
KCKECGKSFSVFSTL

ZNF493

446

Q6ZR52
ECSDCGKSFIKKSQL

ZNF484

441

Q5JVG2
EKLFKCEECGKGFSQ

ZNF227

741

Q86WZ6
KCEECGKAFKQFSNL

ZNF117

306

Q03924
KCEECGKVFKYLSSL

ZNF66

286

Q6ZN08
KCNECGKTFVQKSTL

ZNF510

461

Q9Y2H8
KKCLFLVKCFDKTFE

SWAP70

271

Q9UH65
QYICSFEDCKKTFKK

GTF3A

131

Q92664
CKECGKAFSINAKLT

ZNF23

506

P17027
KVCLAFKQTVCGFDL

PPIP5K2

296

O43314
KSVVCAFFKQGQCTK

ZC3H15

101

Q8WU90
VCKECGKGFTVKSNL

ZNF614

316

Q8N883
EKLYKCTECGKVFIQ

ZNF674

221

Q2M3X9
FECKDCGKAFIQSSK

ZNF623

431

O75123
KVFLDCFCKIAAGIK

UBR4

4656

Q5T4S7
FKCEFCEFVCEDKKA

ZNF335

621

Q9H4Z2
IKVEKFCCAVFAKVP

SLFN5

296

Q08AF3
CVTCGKAFAKKSQLI

ZNF300

271

Q96RE9
ECKTCGKAFKQLTQL

ZNF850

1066

A8MQ14
FKGVSQKAKEFVCFL

TRIO

3016

O75962
VCYKCGKAFVQKSEL

ZNF175

616

Q9Y473
TKETQFKCDICGKIF

ZNF83

116

P51522
KLYKCEECVKAFNSF

ZNF729

766

A6NN14
FLCLQCGKTFTQKKN

ZBTB6

326

Q15916